Publications by authors named "Heinrich Kovar"

66Publications

The YAP/TAZ Pathway in Osteogenesis and Bone Sarcoma Pathogenesis.

Cells 2020 04 15;9(4). Epub 2020 Apr 15.

St. Anna Children's Cancer Research Institute, 1090 Vienna, Austria.

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http://dx.doi.org/10.3390/cells9040972DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7227004PMC
April 2020

Ewing sarcoma.

Nat Rev Dis Primers 2018 07 5;4(1). Epub 2018 Jul 5.

German Cancer Research Center, Heidelberg, Germany.

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http://dx.doi.org/10.1038/s41572-018-0003-xDOI Listing
July 2018

Selective enhancer changes in osteosarcoma lung metastasis.

Authors:
Heinrich Kovar

Nat Med 2018 02;24(2):126-127

Children's Cancer Research Institute, St. Anna Kinderkrebsforschung, Vienna, Austria and the Department of Pediatrics, Medical University, Vienna, Austria.

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http://dx.doi.org/10.1038/nm.4487DOI Listing
February 2018

Ewing Sarcoma: Current Management and Future Approaches Through Collaboration.

J Clin Oncol 2015 Sep 24;33(27):3036-46. Epub 2015 Aug 24.

Nathalie Gaspar, Marie-Cecile Le Deley, and Odile Oberlin, Institut Gustave Roussy, Villejuif; Nathalie Gaspar, Marie-Cecile Le Deley, Line Claude, Olivier Delattre, Jean Michon, Perrine Marec-Bérard, and Odile Oberlin, Société Française de Lutte Contre les Cancers et les Leucémies de l'Enfant et de l'Adolescent; Marie-Cecile Le Deley, Paris-Sud University, Le Kremlin-Bicêtre; Line Claude and Perrine Marec-Bérard, Centre Léon-Bérard, Lyon; Olivier Delattre and Jean Michon, Institut Curie, Paris, France; Douglas S. Hawkins, Seattle Children's Hospital, Seattle, WA; Douglas S. Hawkins, Mark L. Bernstein, and Richard B. Womer, Children's Oncology Group; Uta Dirksen and Heribert Juergens, University Hospital Münster, Münster; Uta Dirksen, Michael Paulussen, and Heribert Juergens, Gesellschaft für Pädiatrische Onkologie und Hämatologie; Michael Paulussen, Children's and Adolescents' Hospital, Witten/Herdecke University, Datteln, Germany; Ian J. Lewis, Alder Hey Children's National Health Service (NHS) Foundation Trust, Liverpool; Ian J. Lewis, Robert Grimer, Bernadette Brennan, and Alan W. Craft, Children's Cancer and Leukaemia Group; Robert Grimer, Royal Orthopaedic Hospital, Birmingham; Jeremy Whelan, University College London Hospital NHS Foundation Trust; Ian Judson, Royal Marsden Hospital, London; Bernadette Brennan, Royal Manchester Children's Hospital, Manchester; Alan W. Craft, Royal Victoria Infirmary, Newcastle, United Kingdom; Stefano Ferrari and Piero Picci, Rizzoli Institute, Bologna; Stefano Ferrari, Piero Picci, Roberto Luksch, Italian Sarcoma Group; Roberto Luksch, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Nazionale dei Tumori, Milan, Italy; Heinrich Kovar and Ruth Ladenstein, Children's Cancer Institute, St Anna Kinderkrebsforschung, Wien; Heinrich Kovar and Ruth Ladenstein, Arbeitsgemeinschaft Ambulant Tätiger Pädiatrischer Onkologen und Hämatologen, Vienna, Austria; Jeremy Whelan and Ian Judson, European O

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http://jco.ascopubs.org/content/33/27/3036.full.pdf
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http://jco.ascopubs.org/cgi/doi/10.1200/JCO.2014.59.5256
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http://dx.doi.org/10.1200/JCO.2014.59.5256DOI Listing
September 2015

SLFN11: Achilles' Heel or Troublemaker.

Authors:
Heinrich Kovar

Clin Cancer Res 2015 Sep 1;21(18):4033-4. Epub 2015 Jun 1.

Children's Cancer Research Institute, St. Anna Kinderkrebsforschung, Vienna, Austria. Department of Pediatrics, Medical University, Vienna, Austria.

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http://dx.doi.org/10.1158/1078-0432.CCR-15-0883DOI Listing
September 2015

EWS-FLI1 employs an E2F switch to drive target gene expression.

Nucleic Acids Res 2015 Mar 20;43(5):2780-9. Epub 2015 Feb 20.

Children's Cancer Research Institute, St. Anna Kinderkrebsforschung, Vienna 1090, Austria Dept. of Pediatrics, Medical University, Vienna 1090, Austria

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http://dx.doi.org/10.1093/nar/gkv123DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4357724PMC
March 2015

Epigenome mapping reveals distinct modes of gene regulation and widespread enhancer reprogramming by the oncogenic fusion protein EWS-FLI1.

Cell Rep 2015 Feb 19;10(7):1082-95. Epub 2015 Feb 19.

Children's Cancer Research Institute, St. Anna Kinderkrebsforschung, 1090 Vienna, Austria; Department of Pediatrics, Medical University of Vienna, 1090 Vienna, Austria. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.01.042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4542316PMC
February 2015

Blocking the road, stopping the engine or killing the driver? Advances in targeting EWS/FLI-1 fusion in Ewing sarcoma as novel therapy.

Authors:
Heinrich Kovar

Expert Opin Ther Targets 2014 Nov 27;18(11):1315-28. Epub 2014 Aug 27.

Children´s Cancer Research Institute, St. Anna Kinderkrebsforschung, and Medical University Vienna, Department of Pediatrics , Zimmermannplatz 10, A1090 Vienna , Austria +43 1 40470 4092 ; +43 1 40470 64092 ;

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http://dx.doi.org/10.1517/14728222.2014.947963DOI Listing
November 2014

Oncogenic ETS fusions deregulate E2F3 target genes in Ewing sarcoma and prostate cancer.

Genome Res 2013 Nov 12;23(11):1797-809. Epub 2013 Aug 12.

Genetics Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, USA;

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http://dx.doi.org/10.1101/gr.151340.112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3814880PMC
November 2013

Notch signalling is off and is uncoupled from HES1 expression in Ewing's sarcoma.

J Pathol 2011 Nov 24;225(3):353-63. Epub 2011 Aug 24.

Children's Cancer Research Institute, St Anna Kinderkrebsforschung, Zimmermannplatz 10, A-1090 Vienna, Austria.

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http://dx.doi.org/10.1002/path.2966DOI Listing
November 2011

The molecular basis of sarcoma.

Sarcoma 2011 7;2011:864130. Epub 2011 Jun 7.

Huntsman Cancer Institute, Center for Children's Cancer Research, 2000 Circle of Hope, Salt Lake City, UT 84112, USA.

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http://dx.doi.org/10.1155/2011/864130DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3137959PMC
November 2011

An integrated chemical biology approach identifies specific vulnerability of Ewing's sarcoma to combined inhibition of Aurora kinases A and B.

Mol Cancer Ther 2011 Oct 18;10(10):1846-56. Epub 2011 Jul 18.

Ce-M-M-Research Center for Molecular Medicine of the Austrian Academy of Sciences, Lazarettgasse 14, AKH BT 25.3, 1090 Vienna, Austria.

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http://dx.doi.org/10.1158/1535-7163.MCT-11-0100DOI Listing
October 2011

Dr. Jekyll and Mr. Hyde: The Two Faces of the FUS/EWS/TAF15 Protein Family.

Authors:
Heinrich Kovar

Sarcoma 2011 9;2011:837474. Epub 2010 Dec 9.

Children's Cancer Research Institute, St. Anna Kinderkrebsforschung, 1090 Vienna, Austria.

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http://dx.doi.org/10.1155/2011/837474DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3005952PMC
July 2011

Intercohort gene expression co-analysis reveals chemokine receptors as prognostic indicators in Ewing's sarcoma.

Clin Cancer Res 2010 Jul 4;16(14):3769-78. Epub 2010 Jun 4.

Children's Cancer Research Institute, St. Anna Kinderkrebsforschung, Vienna, Austria.

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http://dx.doi.org/10.1158/1078-0432.CCR-10-0558DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2905506PMC
July 2010

AURKA inhibitors: right in time.

Authors:
Heinrich Kovar

Pediatr Blood Cancer 2010 Jul;55(1):3-4

Children's Cancer Research Institute Zimmermannplatz 10, Vienna 1090, Austria.

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http://dx.doi.org/10.1002/pbc.22548DOI Listing
July 2010

Downstream EWS/FLI1 - upstream Ewing's sarcoma.

Authors:
Heinrich Kovar

Genome Med 2010 Jan 28;2(1). Epub 2010 Jan 28.

Children's Cancer Research Institute, St Anna Kinderkrebsforschung, Zimmermannplatz 10, 1090 Vienna, Austria.

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http://dx.doi.org/10.1186/gm129DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2829933PMC
January 2010

A molecular function map of Ewing's sarcoma.

PLoS One 2009 30;4(4):e5415. Epub 2009 Apr 30.

Children's Cancer Research Institute, St Anna Kinderkrebsforschung, Vienna, Austria.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0005415PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2671847PMC
August 2009

EZH2 is a mediator of EWS/FLI1 driven tumor growth and metastasis blocking endothelial and neuro-ectodermal differentiation.

Proc Natl Acad Sci U S A 2009 Mar 16;106(13):5324-9. Epub 2009 Mar 16.

Laboratory for Functional Genomics and Transplantation Biology, Department of Pediatrics, Technische Universität München and Pediatric Oncology Center, 81664 Munich, Germany.

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http://dx.doi.org/10.1073/pnas.0810759106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2656557PMC
March 2009

EWS-FLI1 in Ewing's sarcoma: real targets and collateral damage.

Adv Exp Med Biol 2006 ;587:41-52

Children's Cancer Research Institute, Kinderspitalgasse 9, A1190 Vienna, Austria.

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http://dx.doi.org/10.1007/978-1-4020-5133-3_4DOI Listing
January 2007

Caveolin-1 (CAV1) is a target of EWS/FLI-1 and a key determinant of the oncogenic phenotype and tumorigenicity of Ewing's sarcoma cells.

Cancer Res 2006 Oct;66(20):9937-47

Laboratory of Experimental Carcinogenesis, Department of Radiation Medicine, Georgetown University Medical Center, Washington, DC 20057, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-06-0927DOI Listing
October 2006

CD99-positive "Ewing's sarcoma" from mouse-bone marrow-derived mesenchymal progenitor cells?

Cancer Res 2006 Oct;66(19):9786; author reply 9786

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http://dx.doi.org/10.1158/0008-5472.CAN-06-0205DOI Listing
October 2006

Ewing's sarcoma family of tumors: current management.

Oncologist 2006 May;11(5):503-19

Service of Hematology/Oncology, Ste-Justine Hospital, University of Montreal, 3175 Cote Ste. Catherine Road, Montreal, Quebec, H3T 1C5, Canada.

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http://dx.doi.org/10.1634/theoncologist.11-5-503DOI Listing
May 2006

Context matters: the hen or egg problem in Ewing's sarcoma.

Authors:
Heinrich Kovar

Semin Cancer Biol 2005 Jun;15(3):189-96

Children's Cancer Research Institute, St. Anna Kinderspital, Kinderspitalgasse 6, A-1090 Vienna, Austria.

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http://dx.doi.org/10.1016/j.semcancer.2005.01.004DOI Listing
June 2005

EWS-FLI1 target genes recovered from Ewing's sarcoma chromatin.

Oncogene 2005 Apr;24(15):2512-24

Children's Cancer Research Institute (CCRI), St Anna Kinderspital, Kinderspitalgasse 6, Vienna A1090, Austria.

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http://dx.doi.org/10.1038/sj.onc.1208455DOI Listing
April 2005

Constitutive and DNA damage inducible activation of pig3 and MDM2 genes by tumor-derived p53 mutant C277Y.

Mol Cancer Res 2004 May;2(5):296-304

Children's Cancer Research Institute, St. Anna Kinderspital, Kinderspitalgasse 6, A-1090 Vienna, Austria.

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May 2004

Potentials for RNAi in sarcoma research and therapy: Ewing's sarcoma as a model.

Semin Cancer Biol 2003 Aug;13(4):275-81

Children's Cancer Research Institute, St. Anna Kinderspital, Kinderspitalgasse 6, A-1090 Vienna, Austria.

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http://dx.doi.org/10.1016/s1044-579x(03)00041-5DOI Listing
August 2003

Homotypic and heterotypic interactions of EWS, FLI1 and their oncogenic fusion protein.

Oncogene 2003 Oct;22(44):6819-29

Children's Cancer Research Institute, St Anna Kinderspital, A-1090 Vienna, Austria.

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http://dx.doi.org/10.1038/sj.onc.1206810DOI Listing
October 2003

Ewing tumor biology: perspectives for innovative treatment approaches.

Authors:
Heinrich Kovar

Adv Exp Med Biol 2003 ;532:27-37

Children's Cancer Research Institute, St. Anna Kinderspital, Vienna, Austria.

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http://dx.doi.org/10.1007/978-1-4615-0081-0_4DOI Listing
February 2004

Response of Ewing tumor cells to forced and activated p53 expression.

Oncogene 2003 May;22(21):3193-204

Children's Cancer Research Institute, St. Anna Kinderspital, Kinderspitalgasse 6, 1090 Vienna, Austria.

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http://dx.doi.org/10.1038/sj.onc.1206391DOI Listing
May 2003

Interaction of the EWS NH2 terminus with BARD1 links the Ewing's sarcoma gene to a common tumor suppressor pathway.

Cancer Res 2002 Aug;62(16):4583-7

Children's Cancer Research Institute, St. Anna Kinderspital, 1090 Vienna, Austria.

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August 2002