Publications by authors named "Hein W Verspaget"

88Publications

Local but not systemic administration of mesenchymal stromal cells ameliorates fibrogenesis in regenerating livers.

J Cell Mol Med 2019 09 27;23(9):6238-6250. Epub 2019 Jun 27.

Department of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1111/jcmm.14508DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6714167PMC
September 2019

Standardization of mesenchymal stromal cell therapy for perianal fistulizing Crohn's disease.

Eur J Gastroenterol Hepatol 2018 10;30(10):1148-1154

Surgery, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1097/MEG.0000000000001208DOI Listing
October 2018

Quality-Assured Biobanking: The Leiden University Medical Center Model.

Methods Mol Biol 2018 ;1730:361-370

Department of Biobanking, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1007/978-1-4939-7592-1_27DOI Listing
December 2018

Short article: Impact of genetic variation in the vasopressin 1a receptor on the development of organ failure in patients admitted for acute decompensation of liver cirrhosis.

Eur J Gastroenterol Hepatol 2017 May;29(5):535-538

aDepartment of Gastroenterology-Hepatology, Leiden University Medical Center, Leiden, The Netherlands bData Management Center, Hospital Clinic de Barcelona, Barcelona, Spain cLiver Unit, Hospital Clínic de Barcelona, Barcelona, Spain dLiver Unit, Hospital Vall d'Hebron Universitat Autònoma de Barcelona, Centro de Investigación Biomédica en Red Enfermedades Hepáticas y Digestivas (CIBEREHD), Barcelona, Spain eLiver Failure Group, UCL Institute for Liver and Digestive Health, UCL Medical School, Royal Free Hospital, London, UK fDepartment of Gastroenterology-Hepatology, St Vincent's University Hospital, Dublin, Ireland gInternal Medicine, Medical University of Graz, Graz, Austria.

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http://dx.doi.org/10.1097/MEG.0000000000000834DOI Listing
May 2017

Hemodynamic response to primary prophylactic therapy with nonselective β-blockers is related to a reduction of first variceal bleeding risk in liver cirrhosis: a meta-analysis.

Eur J Gastroenterol Hepatol 2017 Apr;29(4):380-387

Departments of aGastroenterology and Hepatology bMedical Statistics and Bio-Informatics, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1097/MEG.0000000000000812DOI Listing
April 2017

Short article: Absence of serological rheumatoid arthritis biomarkers in inflammatory bowel disease patients with arthropathies.

Eur J Gastroenterol Hepatol 2017 Mar;29(3):345-348

Departments of aGastroenterology and Hepatology bRheumatology, Leiden University Medical Center, Leiden, The Netherlands cCenter for Inflammatory Bowel Diseases, University of California Los Angeles, Los Angeles dInova Diagnostics, San Diego, California, USA.

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http://dx.doi.org/10.1097/MEG.0000000000000805DOI Listing
March 2017

Plasma copeptin as biomarker of disease progression and prognosis in cirrhosis.

J Hepatol 2016 11 12;65(5):914-920. Epub 2016 Jul 12.

Liver Unit, Hospital Clínic, University of Barcelona, Barcelona, Spain; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Spain.

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http://dx.doi.org/10.1016/j.jhep.2016.07.003DOI Listing
November 2016

Mass Cytometry of the Human Mucosal Immune System Identifies Tissue- and Disease-Associated Immune Subsets.

Immunity 2016 05 10;44(5):1227-39. Epub 2016 May 10.

Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, 2333 ZA Leiden, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2016.04.014DOI Listing
May 2016

Intraluminal Injection of Mesenchymal Stromal Cells in Spheroids Attenuates Experimental Colitis.

J Crohns Colitis 2016 Aug 19;10(8):953-64. Epub 2016 Feb 19.

Department of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, The Netherlands

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http://dx.doi.org/10.1093/ecco-jcc/jjw047DOI Listing
August 2016

Copeptin is an independent prognostic factor for transplant-free survival in cirrhosis.

Liver Int 2016 Apr 24;36(4):530-7. Epub 2015 Nov 24.

Department of Hepatology, University Hospital of Besançon, Besançon, France.

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http://dx.doi.org/10.1111/liv.12992DOI Listing
April 2016

Diminished expression of CRHR2 in human colon cancer promotes tumor growth and EMT via persistent IL-6/Stat3 signaling.

Cell Mol Gastroenterol Hepatol 2015 Nov;1(6):610-630

IBD Center, Division of Digestive Diseases, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA ; Unidad de Investigacion en Enfermedades Oncologicas, Hospital Infantil de Mexico Federico Gomez, Mexico City, Mexico ; Division of Surgery, School of Medicine, University of Crete, Heraklion, Crete, Greece.

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http://dx.doi.org/10.1016/j.jcmgh.2015.08.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4610032PMC
November 2015

Allogeneic Bone Marrow-Derived Mesenchymal Stromal Cells Promote Healing of Refractory Perianal Fistulas in Patients With Crohn's Disease.

Gastroenterology 2015 Oct 25;149(4):918-27.e6. Epub 2015 Jun 25.

Department of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, The Netherlands; Division of Digestive Diseases, University of California Los Angeles, Los Angeles, California.

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http://dx.doi.org/10.1053/j.gastro.2015.06.014DOI Listing
October 2015

Loss of SMAD4 alters BMP signaling to promote colorectal cancer cell metastasis via activation of Rho and ROCK.

Gastroenterology 2014 Jul 3;147(1):196-208.e13. Epub 2014 Apr 3.

Department of Gastroenterology and Hepatology, Cancer Genomics Centre Netherlands and Centre for Biomedical Genetics, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1053/j.gastro.2014.03.052DOI Listing
July 2014

MMP-2 is a disease-modifying gene in primary sclerosing cholangitis.

Liver Int 2014 Feb 28;34(2):274-80. Epub 2013 Jun 28.

Department of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, the Netherlands.

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http://dx.doi.org/10.1111/liv.12237DOI Listing
February 2014

Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.

Authors:
Luke Jostins Stephan Ripke Rinse K Weersma Richard H Duerr Dermot P McGovern Ken Y Hui James C Lee L Philip Schumm Yashoda Sharma Carl A Anderson Jonah Essers Mitja Mitrovic Kaida Ning Isabelle Cleynen Emilie Theatre Sarah L Spain Soumya Raychaudhuri Philippe Goyette Zhi Wei Clara Abraham Jean-Paul Achkar Tariq Ahmad Leila Amininejad Ashwin N Ananthakrishnan Vibeke Andersen Jane M Andrews Leonard Baidoo Tobias Balschun Peter A Bampton Alain Bitton Gabrielle Boucher Stephan Brand Carsten Büning Ariella Cohain Sven Cichon Mauro D'Amato Dirk De Jong Kathy L Devaney Marla Dubinsky Cathryn Edwards David Ellinghaus Lynnette R Ferguson Denis Franchimont Karin Fransen Richard Gearry Michel Georges Christian Gieger Jürgen Glas Talin Haritunians Ailsa Hart Chris Hawkey Matija Hedl Xinli Hu Tom H Karlsen Limas Kupcinskas Subra Kugathasan Anna Latiano Debby Laukens Ian C Lawrance Charlie W Lees Edouard Louis Gillian Mahy John Mansfield Angharad R Morgan Craig Mowat William Newman Orazio Palmieri Cyriel Y Ponsioen Uros Potocnik Natalie J Prescott Miguel Regueiro Jerome I Rotter Richard K Russell Jeremy D Sanderson Miquel Sans Jack Satsangi Stefan Schreiber Lisa A Simms Jurgita Sventoraityte Stephan R Targan Kent D Taylor Mark Tremelling Hein W Verspaget Martine De Vos Cisca Wijmenga David C Wilson Juliane Winkelmann Ramnik J Xavier Sebastian Zeissig Bin Zhang Clarence K Zhang Hongyu Zhao Mark S Silverberg Vito Annese Hakon Hakonarson Steven R Brant Graham Radford-Smith Christopher G Mathew John D Rioux Eric E Schadt Mark J Daly Andre Franke Miles Parkes Severine Vermeire Jeffrey C Barrett Judy H Cho

Nature 2012 Nov;491(7422):119-24

Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1HH, UK.

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http://dx.doi.org/10.1038/nature11582DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3491803PMC
November 2012

Immunomodulatory effects of mesenchymal stromal cells in Crohn's disease.

J Allergy (Cairo) 2012 20;2012:187408. Epub 2012 Sep 20.

Department of Gastroenterology and Hepatology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.

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http://dx.doi.org/10.1155/2012/187408DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3459229PMC
October 2012

Risk factors for infection after liver transplantation.

Best Pract Res Clin Gastroenterol 2012 Feb;26(1):61-72

Department of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1016/j.bpg.2012.01.004DOI Listing
February 2012

Single-nucleotide polymorphisms of matrix metalloproteinases and their inhibitors in gastrointestinal cancer.

World J Gastrointest Oncol 2011 Jun;3(6):79-98

Alexandra MJ Langers, Hein W Verspaget, Daniel W Hommes, Cornelis FM Sier, Department of Gastroenterology and Hepatology, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands.

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http://dx.doi.org/10.4251/wjgo.v3.i6.79DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3124635PMC
June 2011

Clinical applications of the urokinase receptor (uPAR) for cancer patients.

Curr Pharm Des 2011 ;17(19):1890-910

Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.2174/138161211796718233DOI Listing
December 2011

Symptoms in patients with ulcerative colitis in remission are associated with visceral hypersensitivity and mast cell activity.

Scand J Gastroenterol 2011 Jul 30;46(7-8):981-7. Epub 2011 May 30.

Department of Internal Medicine, Division of Gastroenterology and Hepatology, Maastricht University Medical Center, Maastricht, The Netherlands.

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http://dx.doi.org/10.3109/00365521.2011.579156DOI Listing
July 2011

Neutralizing antibodies against adeno-associated viruses in inflammatory bowel disease patients: implications for gene therapy.

Inflamm Bowel Dis 2011 Dec 2;17(12):2436-42. Epub 2011 Mar 2.

Research and Development, Amsterdam Molecular Therapeutics (AMT) B.V., Amsterdam, the Netherlands; Department of Gastroenterology & Hepatology, Leiden University Medical Center, Leiden, the Netherlands.

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http://dx.doi.org/10.1002/ibd.21673DOI Listing
December 2011

Angiogenic markers endoglin and vascular endothelial growth factor in gastroenteropancreatic neuroendocrine tumors.

World J Gastroenterol 2011 Jan;17(2):219-25

Department of Gastroenterology and Hepatology, Leiden University Medical Centre, 2300 RC Leiden, The Netherlands.

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http://dx.doi.org/10.3748/wjg.v17.i2.219DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3020376PMC
January 2011

Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.

Nat Genet 2010 Dec;42(12):1118-25

Institute of Clinical Molecular Biology, Christian-Albrechts-University Kiel, Kiel, Germany.

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http://dx.doi.org/10.1038/ng.717DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3299551PMC
December 2010

Pathological incidence of duodenopancreatic neuroendocrine tumors in the Netherlands: a Pathologisch Anatomisch Landelijk Geautomatiseerd Archief study.

Pancreas 2010 Nov;39(8):1134-9

Department of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1097/MPA.0b013e3181f3a681DOI Listing
November 2010

Matrix metalloproteinase-14 (MT1-MMP)-mediated endoglin shedding inhibits tumor angiogenesis.

Cancer Res 2010 May 27;70(10):4141-50. Epub 2010 Apr 27.

Departmentsof Molecular Cell Biology, Centre for Biomedical Genetics, Gastroenterology-Hepatology, and Surgery, Leiden University Medical Center, Leiden, the Netherlands.

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http://dx.doi.org/10.1158/0008-5472.CAN-09-4466DOI Listing
May 2010

Diagnostic efficacy of the secretin stimulation test for the Zollinger-Ellison syndrome: an intra-individual comparison using different dosages in patients and controls.

Pancreatology 2010 19;10(1):14-8. Epub 2010 Mar 19.

Department of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, The Netherlands. p.kuiper @ lumc.nl

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http://linkinghub.elsevier.com/retrieve/pii/S142439031080005
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http://dx.doi.org/10.1159/000265936DOI Listing
July 2010

A new conditional Apc-mutant mouse model for colorectal cancer.

Carcinogenesis 2010 May 22;31(5):946-52. Epub 2010 Feb 22.

Department of Human Genetics, Leiden University Medical Center, 2300 RC Leiden, The Netherlands.

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http://dx.doi.org/10.1093/carcin/bgq046DOI Listing
May 2010

5-aminosalicylic acid interferes in the cell cycle of colorectal cancer cells and induces cell death modes.

Inflamm Bowel Dis 2010 Mar;16(3):379-89

Department of Gastroenterology and Hepatology, and Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1002/ibd.21086DOI Listing
March 2010

5-Aminosalicylic acid inhibits TGF-beta1 signalling in colorectal cancer cells.

Cancer Lett 2010 Jan 21;287(1):82-90. Epub 2009 Jun 21.

Department of Gastroenterology-Hepatology, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands.

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http://dx.doi.org/10.1016/j.canlet.2009.05.033DOI Listing
January 2010

Circulating cell death products predict clinical outcome of colorectal cancer patients.

BMC Cancer 2009 Mar 23;9:88. Epub 2009 Mar 23.

Department of Gastroenterology and Hepatology, Leiden University Medical Centre, C4-P, P,O, Box 9600, 2300 RC Leiden, The Netherlands.

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http://dx.doi.org/10.1186/1471-2407-9-88DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2666761PMC
March 2009

VEGF release by MMP-9 mediated heparan sulphate cleavage induces colorectal cancer angiogenesis.

Eur J Cancer 2008 Sep 6;44(13):1904-13. Epub 2008 Aug 6.

Department of Gastroenterology-Hepatology, Leiden University Medical Centre, P.O. Box 9600, 2300 RC Leiden, The Netherlands.

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http://dx.doi.org/10.1016/j.ejca.2008.06.031DOI Listing
September 2008

Gastroduodenal Crohn's disease and pancreatitis.

Gastroenterol Hepatol (N Y) 2008 Jul;4(7):496-8

Department of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, The Netherlands.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3096134PMC
July 2008

Phosphoprotein Keratin 23 accumulates in MSS but not MSI colon cancers in vivo and impacts viability and proliferation in vitro.

Mol Oncol 2007 Sep 3;1(2):181-95. Epub 2007 Jun 3.

Molecular Diagnostic Laboratory, Department of Clinical Biochemistry, Aarhus University Hospital/Skejby, Brendstrupgaardsvej, DK-8200 Aarhus N, Denmark.

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http://dx.doi.org/10.1016/j.molonc.2007.05.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5543893PMC
September 2007

Clinical evidence for a protective role of lipocalin-2 against MMP-9 autodegradation and the impact for gastric cancer.

Eur J Cancer 2007 Aug 2;43(12):1869-76. Epub 2007 Jul 2.

Department of Gastroenterology - Hepatology, Leiden University Medical Centre, P.O. Box 9600, 2300 RC Leiden, The Netherlands.

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http://dx.doi.org/10.1016/j.ejca.2007.05.013DOI Listing
August 2007

5-ASA and colorectal cell-cycle progression.

Gastroenterology 2007 Apr;132(4):1635-6; author reply 1636

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http://dx.doi.org/10.1053/j.gastro.2007.03.008DOI Listing
April 2007

Low prevalence of Helicobacter pylori infection in young children in the Netherlands.

Eur J Gastroenterol Hepatol 2007 Mar;19(3):213-6

Department of Pediatric Gastroenterology, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1097/MEG.0b013e328011050fDOI Listing
March 2007

Role of tumor necrosis factor-alpha and interleukin-10 gene polymorphisms in irritable bowel syndrome.

Am J Gastroenterol 2005 Nov;100(11):2510-6

Department of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1111/j.1572-0241.2005.00257.xDOI Listing
November 2005

Assessment of serum matrix metalloproteinases MMP-2 and MMP-9 after human liver transplantation: increased serum MMP-9 level in acute rejection.

Transplantation 2004 Jun;77(11):1646-52

Department of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1097/01.tp.0000131170.67671.75DOI Listing
June 2004

Intestinal oxidative damage in inflammatory bowel disease: semi-quantification, localization, and association with mucosal antioxidants.

J Pathol 2003 Sep;201(1):28-36

Department of Gastroenterology and Hepatology, Leiden University Medical Center, The Netherlands.

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http://dx.doi.org/10.1002/path.1409DOI Listing
September 2003

Imbalanced secondary mucosal antioxidant response in inflammatory bowel disease.

J Pathol 2003 Sep;201(1):17-27

Department of Gastroenterology and Hepatology, Leiden University Medical Center, The Netherlands.

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http://dx.doi.org/10.1002/path.1408DOI Listing
September 2003

Differential mucosal expression of three superoxide dismutase isoforms in inflammatory bowel disease.

J Pathol 2003 Sep;201(1):7-16

Department of Gastroenterology and Hepatology, Leiden University Medical Center, The Netherlands.

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http://dx.doi.org/10.1002/path.1407DOI Listing
September 2003

Assessment of the clinical significance of serum matrix metalloproteinases MMP-2 and MMP-9 in patients with various chronic liver diseases and hepatocellular carcinoma.

Thromb Haemost 2003 Apr;89(4):718-25

Department of Gastroenterology and Hepatology, Leiden University Medical Center, C4-P, P.O. Box 9600, 2300 RC Leiden, The Netherlands.

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April 2003

Attenuated mild colonic inflammation and improved survival from severe DSS-colitis of transgenic Cu/Zn-SOD mice.

Free Radic Biol Med 2003 Mar;34(6):753-65

Department of Gastroenterology-Hepatology, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1016/s0891-5849(02)01426-0DOI Listing
March 2003

Prognostic significance of metallothionein in human gastrointestinal cancer.

Clin Cancer Res 2002 Jun;8(6):1889-96

Department of Gastroenterology and Hepatology, Leiden University Medical Center, 2300 RC Leiden, the Netherlands.

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June 2002