Publications by authors named "Heiko Witt"

89Publications

Sequencing of the complex CTRB1-CTRB2 locus in chronic pancreatitis.

Pancreatology 2020 Sep 29. Epub 2020 Sep 29.

Department of Internal Medicine I, Martin Luther University, Halle, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.pan.2020.09.017DOI Listing
September 2020

IRF5 Is Required for Bacterial Clearance in Human M1-Polarized Macrophages, and Immune-Mediated Disease Risk Variants Modulate This Outcome.

J Immunol 2019 02 28;202(3):920-930. Epub 2018 Dec 28.

Department of Internal Medicine, Yale University, New Haven, CT 06520; and

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http://dx.doi.org/10.4049/jimmunol.1800226DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6585431PMC
February 2019

EPC/HPSG evidence-based guidelines for the management of pediatric pancreatitis.

Pancreatology 2018 Mar 4;18(2):146-160. Epub 2018 Jan 4.

Institute for Translational Medicine, University of Pécs, Pécs, Hungary; First Department of Medicine, University of Szeged, Szeged, Hungary. Electronic address:

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http://dx.doi.org/10.1016/j.pan.2018.01.001DOI Listing
March 2018

Identification of essential amino acids for glucose transporter 5 (GLUT5)-mediated fructose transport.

J Biol Chem 2018 02 19;293(6):2115-2124. Epub 2017 Dec 19.

From the Pediatric Nutritional Medicine, Klinikum rechts der Isar (MRI), Else Kröner-Fresenius-Zentrum für Ernährungsmedizin,

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http://dx.doi.org/10.1074/jbc.RA117.001442DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5808771PMC
February 2018

Genome-wide association study identifies inversion in the locus to modify risk for alcoholic and non-alcoholic chronic pancreatitis.

Gut 2018 10 28;67(10):1855-1863. Epub 2017 Jul 28.

Department of Molecular and Cell Biology, Center for Exocrine Disorders, Boston University Henry M. Goldman School of Dental Medicine, Boston, Massachusetts, USA.

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http://gut.bmj.com/lookup/doi/10.1136/gutjnl-2017-314454
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http://dx.doi.org/10.1136/gutjnl-2017-314454DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6145291PMC
October 2018

[No Magic Bullet: Genetic Diagnostics and Predictive Testing].

Authors:
Heiko Witt

Dtsch Med Wochenschr 2017 May 28;142(9):652-656. Epub 2017 Apr 28.

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http://dx.doi.org/10.1055/s-0043-101829DOI Listing
May 2017

Reassessment of GLUT7 and GLUT9 as Putative Fructose and Glucose Transporters.

J Membr Biol 2017 04 12;250(2):171-182. Epub 2017 Jan 12.

Pediatric Nutritional Medicine, Klinikum rechts der Isar (MRI), Else Kröner-Fresenius-Zentrum für Ernährungsmedizin (EKFZ), Technische Universität München, Fachgebiet Pädiatrische Ernährungsmedizin, Gregor-Mendel-Str. 2, 85354, Freising, Germany.

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http://dx.doi.org/10.1007/s00232-016-9945-7DOI Listing
April 2017

Complex Formation of Human Proelastases with Procarboxypeptidases A1 and A2.

J Biol Chem 2016 08 29;291(34):17706-16. Epub 2016 Jun 29.

From the Department of Molecular and Cell Biology and Center for Exocrine Disorders, Boston University Henry M. Goldman School of Dental Medicine, Boston, Massachusetts 02118,

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http://www.jbc.org/lookup/doi/10.1074/jbc.M116.743237
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http://dx.doi.org/10.1074/jbc.M116.743237DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5016165PMC
August 2016

Fructose malabsorption.

Mol Cell Pediatr 2016 Dec 16;3(1):10. Epub 2016 Feb 16.

Pädiatrische Ernährungsmedizin, Klinikum rechts der Isar (MRI), Technische Universität München (TUM), Gregor-MendelStr. 2, 85354, Freising, Germany.

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http://dx.doi.org/10.1186/s40348-016-0035-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4755956PMC
December 2016

BCL3 Reduces the Sterile Inflammatory Response in Pancreatic and Biliary Tissues.

Gastroenterology 2016 Feb 23;150(2):499-512.e20. Epub 2015 Oct 23.

Department of Medicine II, Klinikum Rechts der Isar, Technische Universität München, Munich, Germany. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2015.10.017DOI Listing
February 2016

Variants in pancreatic carboxypeptidase genes CPA2 and CPB1 are not associated with chronic pancreatitis.

Am J Physiol Gastrointest Liver Physiol 2015 Oct 27;309(8):G688-94. Epub 2015 Aug 27.

Pediatric Nutritional Medicine, Klinikum rechts der Isar; Else Kröner-Fresenius-Zentrum für Ernährungsmedizin & Zentralinstitut für Ernährungs-und Lebensmittelforschung, Technische Universität München, Munich, Germany; and.

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http://dx.doi.org/10.1152/ajpgi.00241.2015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4609930PMC
October 2015

Mesotrypsin Signature Mutation in a Chymotrypsin C (CTRC) Variant Associated with Chronic Pancreatitis.

J Biol Chem 2015 Jul 26;290(28):17282-92. Epub 2015 May 26.

From the Department of Molecular and Cell Biology, Boston University Henry M. Goldman School of Dental Medicine, Boston, Massachusetts 02118,

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http://dx.doi.org/10.1074/jbc.M114.618439DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4498067PMC
July 2015

Genetic variants of lipase activity in chronic pancreatitis.

Gut 2016 Jan 26;65(1):184-5. Epub 2015 Mar 26.

Division of Gastroenterology and Rheumatology, Department of Internal Medicine, Neurology and Dermatology, University of Leipzig, Leipzig, Germany.

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http://dx.doi.org/10.1136/gutjnl-2015-309521DOI Listing
January 2016

Polymorphisms at PRSS1-PRSS2 and CLDN2-MORC4 loci associate with alcoholic and non-alcoholic chronic pancreatitis in a European replication study.

Gut 2015 Sep 24;64(9):1426-33. Epub 2014 Sep 24.

Department of Internal Medicine, Neurology and Dermatology, Division of Gastroenterology and Rheumatology, University of Leipzig, Leipzig, Germany.

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http://dx.doi.org/10.1136/gutjnl-2014-307453DOI Listing
September 2015

Myosin IXb variants and their pivotal role in maintaining the intestinal barrier: a study in Crohn's disease.

Scand J Gastroenterol 2014 Oct 6;49(10):1191-200. Epub 2014 Aug 6.

Department of Gastroenterology and Hepatology, Charité, Campus Mitte, Universitätsmedizin Berlin , Berlin , Germany.

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http://dx.doi.org/10.3109/00365521.2014.928903DOI Listing
October 2014

Colonic expression of the peptide transporter PEPT1 is downregulated during intestinal inflammation and is not required for NOD2-dependent immune activation.

Inflamm Bowel Dis 2014 Apr;20(4):671-84

1Technische Universität München, ZIEL-Research Center for Nutrition and Food Science, Biochemistry Unit, Weihenstephan, Germany; 2Institute of Pathology, Charité-Universitätsmedizin Berlin, Campus Mitte, Berlin, Germany; 3Institut Pasteur de Lille, Center for Infection and Immunity of Lille, Lille, France; 4Université Lille Nord de France, Lille, France; 5Centre national de la recherche scientifique, Unité Mixte de Recherche, Lille, France; 6Institut National de la Santé et de la Recherche Médicale, Lille, France; 7Technische Universität München, ZIEL-Research Center for Nutrition and Food Science, Biofunctionality Unit, Weihenstephan, Germany; 8Institute of Microbiology and Hygiene, Charité-Universitätsmedizin Berlin, Campus Benjamin-Franklin, Berlin, Germany; 9Center for Gastrointestinal Biology and Disease, University of North Carolina, Chapel Hill, North Carolina; 10Department of Gastroenterology, Infectiology and Rheumatology, Charité-Universitätsmedizin Berlin, Campus Mitte, Berlin, Germany; 11Institute of Transfusion Medicine and Immunology, Medical Faculty Mannheim, Heidelberg University, German Red Cross Blood Service of Baden-Württemberg-Hessen, Mannheim, Germany; 12Else Kröner-Fresenius-Zentrum für Ernährungsmedizin (EKFZ) and ZIEL-Research Center for Nutrition and Food Science, Technische Universität München (TUM), Weihenstephan, Germany; and 13Department of Pediatrics, Klinikum rechts der Isar (MRI), Technische Universität München (TUM), Munich, Germany. T. Wuensch is now with Department of Cell and Molecular Biology, Karolinska Institute, von Eulersväg 3, Stockholm, Sweden.

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http://dx.doi.org/10.1097/01.MIB.0000443336.71488.08DOI Listing
April 2014

Mutational analysis of ATP8B1 in patients with chronic pancreatitis.

PLoS One 2013 19;8(11):e80553. Epub 2013 Nov 19.

Department of Pediatric Gastroenterology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, The Netherlands ; Department of Metabolic Diseases, University Medical Center Utrecht, Utrecht, The Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0080553PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3834041PMC
August 2014

Rapid progression of a splenic aneurysm due to segmental arterial mediolysis: a rare cause of acute pancreatitis.

Pancreatology 2013 Sep-Oct;13(5):553-6. Epub 2013 Jun 19.

Gastrocentrum, Karolinska Institute & University Hospital Huddinge, Stockholm, Sweden; Dept. of Medicine II, University Medical Center Mannheim, University of Heidelberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.pan.2013.06.001DOI Listing
May 2014

Variants in CPA1 are strongly associated with early onset chronic pancreatitis.

Nat Genet 2013 Oct 18;45(10):1216-20. Epub 2013 Aug 18.

1] Else Kröner-Fresenius-Zentrum für Ernährungsmedizin (EKFZ), Technische Universität München (TUM), Freising, Germany. [2] Zentralinstitut für Ernährungs- und Lebensmittelforschung (ZIEL), TUM, Freising, Germany. [3] Department of Pediatrics, Klinikum Rechts der Isar (MRI), TUM, Munich, Germany.

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http://dx.doi.org/10.1038/ng.2730DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3909499PMC
October 2013

Chronic pancreatitis--definition, etiology, investigation and treatment.

Dtsch Arztebl Int 2013 May 31;110(22):387-93. Epub 2013 May 31.

University Medicine Greifswald, Department of Internal Medicine A.

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http://dx.doi.org/10.3238/arztebl.2013.0387DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3698906PMC
May 2013

Functional effects of 13 rare PRSS1 variants presumed to cause chronic pancreatitis.

Gut 2014 Feb 1;63(2):337-43. Epub 2013 Mar 1.

Department of Molecular and Cell Biology, Henry M. Goldman School of Dental Medicine, Boston University, , Boston, Massachusetts, USA.

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http://dx.doi.org/10.1136/gutjnl-2012-304331DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3681892PMC
February 2014

New modifier loci in cystic fibrosis.

Authors:
Heiko Witt

Nat Genet 2011 Jun;43(6):508-9

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http://dx.doi.org/10.1038/ng.844DOI Listing
June 2011

Assessing the pathological relevance of SPINK1 promoter variants.

Eur J Hum Genet 2011 Oct 25;19(10):1066-73. Epub 2011 May 25.

Institut National de Santé et de Recherche Médicale (INSERM), U613, Brest, France.

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http://dx.doi.org/10.1038/ejhg.2011.79DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3190254PMC
October 2011

Genetics of pancreatitis: a guide for clinicians.

Authors:
Heiko Witt

Dig Dis 2010 27;28(6):702-8. Epub 2011 Apr 27.

Department of Pediatrics, Technische Universität München (TUM), Munich, Germany.

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http://dx.doi.org/10.1159/000324276DOI Listing
August 2011

Evaluation of angiotensinogen c.1-44G>A and p.M268T variants as risk factors for fibrosis progression in chronic hepatitis C and liver diseases of various etiologies.

Genet Test Mol Biomarkers 2009 Jun;13(3):407-14

Medizinische Klinik mit Schwerpunkt Hepatologie und Gastroenterologie, Charité Universitätsmedizin Berlin, Berlin, Germany.

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http://dx.doi.org/10.1089/gtmb.2008.0135DOI Listing
June 2009

Interleukin 18 promoter variants (-137G>C and -607C>A) in patients with chronic hepatitis C: association with treatment response.

J Clin Immunol 2009 Sep 20;29(5):620-8. Epub 2009 May 20.

Department of Medicine II, Medical Faculty at Mannheim, University of Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim, Germany.

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http://dx.doi.org/10.1007/s10875-009-9302-zDOI Listing
September 2009

IL13 variants are associated with total serum IgE and early sensitization to food allergens in children with atopic dermatitis.

Pediatr Allergy Immunol 2009 Sep 10;20(6):551-5. Epub 2009 Jun 10.

Department of Pediatric Pneumology and Immunology, Charité - Universitätsmedizin Berlin, Berlin, Germany.

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http://dx.doi.org/10.1111/j.1399-3038.2008.00815.xDOI Listing
September 2009

ICOS-gene variants are not associated with atopic disease susceptibility in European children.

Pediatr Allergy Immunol 2009 May 6;20(3):242-5. Epub 2008 Oct 6.

Department of Paediatric Pneumology and Immunology, Charité- Universitätsmedizin Berlin, Campus Virchow-Klinikum, Berlin, Germany.

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http://dx.doi.org/10.1111/j.1399-3038.2008.00777.xDOI Listing
May 2009

Divergent roles of SPINK1 and PRSS2 variants in tropical calcific pancreatitis.

Pancreatology 2009 13;9(1-2):145-9. Epub 2008 Dec 13.

Department of Medicine, Division of Gastroenterology and Hepatology, Radboud University Medical Center Nijmegen, Nijmegen, The Netherlands.

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https://linkinghub.elsevier.com/retrieve/pii/S14243903098008
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http://dx.doi.org/10.1159/000178885DOI Listing
July 2009

A common African polymorphism abolishes tyrosine sulfation of human anionic trypsinogen (PRSS2).

Biochem J 2009 Feb;418(1):155-61

Department of Molecular and Cell Biology, Boston University Goldman School of Dental Medicine, Boston, MA 02118, USA.

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http://dx.doi.org/10.1042/BJ20081848DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2700036PMC
February 2009

Evaluation of complement factor 5 variants as genetic risk factors for the development of advanced fibrosis in chronic hepatitis C infection.

J Hepatol 2008 Sep 23;49(3):339-45. Epub 2008 Jun 23.

Medizinische Klinik mit Schwerpunkt Hepatologie und Gastroenterologie, Charité - Universitätsmedizin Berlin, Campus Virchow-Klinikum, Germany.

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http://dx.doi.org/10.1016/j.jhep.2008.05.021DOI Listing
September 2008

The SPINK1 N34S variant is associated with acute pancreatitis.

Eur J Gastroenterol Hepatol 2008 Aug;20(8):726-31

Department of Surgery, Derriford Hospital, University of Plymouth, Plymouth, UK.

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http://dx.doi.org/10.1097/MEG.0b013e3282f5728cDOI Listing
August 2008

Genetic aspects of tropical calcific pancreatitis.

Rev Endocr Metab Disord 2008 Sep;9(3):213-26

Klinik und Poliklinik für Kinder- und Jugendmedizin des Klinikums rechts der Isar, Technische Universität München, Kölner Platz 1, 80804 Munich, Germany.

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http://dx.doi.org/10.1007/s11154-008-9088-yDOI Listing
September 2008

Relevance of endotoxin receptor CD14 and TLR4 gene variants in chronic liver disease.

Scand J Gastroenterol 2008 ;43(5):584-92

Medizinische Klinik mit Schwerpunkt Hepatologie und Gastroenterologie, Charité-Universitätsmedizin Berlin, Campus Virchow-Klinikum, Germany.

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http://www.tandfonline.com/doi/full/10.1080/0036552070180606
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http://dx.doi.org/10.1080/00365520701806065DOI Listing
June 2008

MBL2 variants in relation to common childhood infections and atopy-related phenotypes in a large German birth cohort.

Pediatr Allergy Immunol 2007 Dec 25;18(8):665-70. Epub 2007 Jul 25.

Department of Pediatric Pneumology and Immunology, Charité-Universitäts medizin, Berlin, Germany.

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http://doi.wiley.com/10.1111/j.1399-3038.2007.00573.x
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http://dx.doi.org/10.1111/j.1399-3038.2007.00573.xDOI Listing
December 2007

Chronic pancreatitis: challenges and advances in pathogenesis, genetics, diagnosis, and therapy.

Gastroenterology 2007 Apr;132(4):1557-73

Department of Hepatology and Gastroenterology, Charité, Campus Virchow-Klinikum, Universitätsmedizin Berlin, Berlin, Germany.

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http://dx.doi.org/10.1053/j.gastro.2007.03.001DOI Listing
April 2007

Gender-dependent association of CTLA4 polymorphisms with resolution of hepatitis C virus infection.

J Hepatol 2007 Mar 2;46(3):372-80. Epub 2006 Nov 2.

Department of Hepatology and Gastroenterology, CVK, Charité Universitätsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany.

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http://dx.doi.org/10.1016/j.jhep.2006.09.011DOI Listing
March 2007

DLG5 variants in inflammatory bowel disease.

Am J Gastroenterol 2006 Apr 22;101(4):786-92. Epub 2006 Feb 22.

Department of Gastroenterology, Hepatology & Endocrinology, Charité, Campus Mitte, Universitätsmedizin Berlin, Berlin, Germany.

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http://dx.doi.org/10.1111/j.1572-0241.2006.00431.xDOI Listing
April 2006

Evaluation of the -26G>A CC16 polymorphism in acute respiratory distress syndrome.

Crit Care Med 2005 Oct;33(10):2404-6

Department of Anesthesiology, Charité, Universitätsmedizin Berlin, Berlin, Germany.

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http://dx.doi.org/10.1097/01.ccm.0000181526.24809.3eDOI Listing
October 2005

Influence of interleukin 12B (IL12B) polymorphisms on spontaneous and treatment-induced recovery from hepatitis C virus infection.

J Hepatol 2004 Oct;41(4):652-8

Charité, Campus Virchow-Klinikum, Medizinische Klinik mit Schwerpunkt, Hepatologie und Gastroenterologie, Universitätsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany.

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http://dx.doi.org/10.1016/j.jhep.2004.06.021DOI Listing
October 2004

Smads as intracellular mediators of airway inflammation.

Exp Lung Res 2004 Apr-May;30(3):223-50

Division of Allergy Research, Department of Pediatric Pneumology and Immunology, Charité Campus-Virchow, Humboldt-University, Berlin, Germany.

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http://dx.doi.org/10.1080/01902140490276320DOI Listing
July 2004

Analysis of tumour necrosis factor alpha and interleukin 10 promotor variants in patients with chronic pancreatitis.

Eur J Gastroenterol Hepatol 2003 Nov;15(11):1223-7

Medizinische Klinik und Poliklinik II, Universität Leipzig, Leipzig, Kinderklinik, Charité Berlin, Berlin, Germany.

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http://dx.doi.org/10.1097/00042737-200311000-00012DOI Listing
November 2003

The course of genetically determined chronic pancreatitis.

JOP 2003 Jul;4(4):146-54

Medizinische Klinik II, Universitätsklinikum Leipzig, Germany.

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July 2003

N34S, a pancreatitis associated SPINK1 mutation, is not associated with sporadic pancreatic cancer.

Pancreatology 2003 ;3(1):67-8

Medizinische Klinik und Poliklinik II, Universitätsklinikum Leipzig, Deutschland.

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http://linkinghub.elsevier.com/retrieve/pii/S142439030380010
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http://dx.doi.org/10.1159/000069145DOI Listing
October 2003

Tropical calcific pancreatitis: strong association with SPINK1 trypsin inhibitor mutations.

Gastroenterology 2002 Oct;123(4):1020-5

Department of Endocrinology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India.

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http://dx.doi.org/10.1053/gast.2002.36028DOI Listing
October 2002

Genetics of chronic pancreatitis.

J Pediatr Gastroenterol Nutr 2002 Feb;34(2):125-36

Department of Paediatrics, Charité, Campus Virchow-Klinikum, Humboldt University, Berlin, Germany.

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http://dx.doi.org/10.1097/00005176-200202000-00006DOI Listing
February 2002