Heiko Runz

Heiko Runz

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Heiko Runz

Heiko Runz

Publications by authors named "Heiko Runz"

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Genome-wide association meta-analyses and fine-mapping elucidate pathways influencing albuminuria.

Authors:
Alexander Teumer Yong Li Sahar Ghasemi Bram P Prins Matthias Wuttke Tobias Hermle Ayush Giri Karsten B Sieber Chengxiang Qiu Holger Kirsten Adrienne Tin Audrey Y Chu Nisha Bansal Mary F Feitosa Lihua Wang Jin-Fang Chai Massimiliano Cocca Christian Fuchsberger Mathias Gorski Anselm Hoppmann Katrin Horn Man Li Jonathan Marten Damia Noce Teresa Nutile Sanaz Sedaghat Gardar Sveinbjornsson Bamidele O Tayo Peter J van der Most Yizhe Xu Zhi Yu Lea Gerstner Johan Ärnlöv Stephan J L Bakker Daniela Baptista Mary L Biggs Eric Boerwinkle Hermann Brenner Ralph Burkhardt Robert J Carroll Miao-Li Chee Miao-Ling Chee Mengmeng Chen Ching-Yu Cheng James P Cook Josef Coresh Tanguy Corre John Danesh Martin H de Borst Alessandro De Grandi Renée de Mutsert Aiko P J de Vries Frauke Degenhardt Katalin Dittrich Jasmin Divers Kai-Uwe Eckardt Georg Ehret Karlhans Endlich Janine F Felix Oscar H Franco Andre Franke Barry I Freedman Sandra Freitag-Wolf Ron T Gansevoort Vilmantas Giedraitis Martin Gögele Franziska Grundner-Culemann Daniel F Gudbjartsson Vilmundur Gudnason Pavel Hamet Tamara B Harris Andrew A Hicks Hilma Holm Valencia Hui Xian Foo Shih-Jen Hwang M Arfan Ikram Erik Ingelsson Vincent W V Jaddoe Johanna Jakobsdottir Navya Shilpa Josyula Bettina Jung Mika Kähönen Chiea-Chuen Khor Wieland Kiess Wolfgang Koenig Antje Körner Peter Kovacs Holly Kramer Bernhard K Krämer Florian Kronenberg Leslie A Lange Carl D Langefeld Jeannette Jen-Mai Lee Terho Lehtimäki Wolfgang Lieb Su-Chi Lim Lars Lind Cecilia M Lindgren Jianjun Liu Markus Loeffler Leo-Pekka Lyytikäinen Anubha Mahajan Joseph C Maranville Deborah Mascalzoni Barbara McMullen Christa Meisinger Thomas Meitinger Kozeta Miliku Dennis O Mook-Kanamori Martina Müller-Nurasyid Josyf C Mychaleckyj Matthias Nauck Kjell Nikus Boting Ning Raymond Noordam Jeffrey O' Connell Isleifur Olafsson Nicholette D Palmer Annette Peters Anna I Podgornaia Belen Ponte Tanja Poulain Peter P Pramstaller Ton J Rabelink Laura M Raffield Dermot F Reilly Rainer Rettig Myriam Rheinberger Kenneth M Rice Fernando Rivadeneira Heiko Runz Kathleen A Ryan Charumathi Sabanayagam Kai-Uwe Saum Ben Schöttker Christian M Shaffer Yuan Shi Albert V Smith Konstantin Strauch Michael Stumvoll Benjamin B Sun Silke Szymczak E-Shyong Tai Nicholas Y Q Tan Kent D Taylor Andrej Teren Yih-Chung Tham Joachim Thiery Chris H L Thio Hauke Thomsen Unnur Thorsteinsdottir Anke Tönjes Johanne Tremblay André G Uitterlinden Pim van der Harst Niek Verweij Suzanne Vogelezang Uwe Völker Melanie Waldenberger Chaolong Wang Otis D Wilson Charlene Wong Tien-Yin Wong Qiong Yang Masayuki Yasuda Shreeram Akilesh Murielle Bochud Carsten A Böger Olivier Devuyst Todd L Edwards Kevin Ho Andrew P Morris Afshin Parsa Sarah A Pendergrass Bruce M Psaty Jerome I Rotter Kari Stefansson James G Wilson Katalin Susztak Harold Snieder Iris M Heid Markus Scholz Adam S Butterworth Adriana M Hung Cristian Pattaro Anna Köttgen

Nat Commun 2019 Sep 11;10(1):4130. Epub 2019 Sep 11.

Institute of Genetic Epidemiology, Department of Biometry, Epidemiology and Medical Bioinformatics, Faculty of Medicine and Medical Center - University of Freiburg, Freiburg, Germany.

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http://dx.doi.org/10.1038/s41467-019-11576-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6739370PMC
September 2019

Author Correction: New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries.

Authors:
Nick Shrine Anna L Guyatt A Mesut Erzurumluoglu Victoria E Jackson Brian D Hobbs Carl A Melbourne Chiara Batini Katherine A Fawcett Kijoung Song Phuwanat Sakornsakolpat Xingnan Li Ruth Boxall Nicola F Reeve Ma'en Obeidat Jing Hua Zhao Matthias Wielscher Stefan Weiss Katherine A Kentistou James P Cook Benjamin B Sun Jian Zhou Jennie Hui Stefan Karrasch Medea Imboden Sarah E Harris Jonathan Marten Stefan Enroth Shona M Kerr Ida Surakka Veronique Vitart Terho Lehtimäki Richard J Allen Per S Bakke Terri H Beaty Eugene R Bleecker Yohan Bossé Corry-Anke Brandsma Zhengming Chen James D Crapo John Danesh Dawn L DeMeo Frank Dudbridge Ralf Ewert Christian Gieger Amund Gulsvik Anna L Hansell Ke Hao Joshua D Hoffman John E Hokanson Georg Homuth Peter K Joshi Philippe Joubert Claudia Langenberg Xuan Li Liming Li Kuang Lin Lars Lind Nicholas Locantore Jian'an Luan Anubha Mahajan Joseph C Maranville Alison Murray David C Nickle Richard Packer Margaret M Parker Megan L Paynton David J Porteous Dmitry Prokopenko Dandi Qiao Rajesh Rawal Heiko Runz Ian Sayers Don D Sin Blair H Smith María Soler Artigas David Sparrow Ruth Tal-Singer Paul R H J Timmers Maarten Van den Berge John C Whittaker Prescott G Woodruff Laura M Yerges-Armstrong Olga G Troyanskaya Olli T Raitakari Mika Kähönen Ozren Polašek Ulf Gyllensten Igor Rudan Ian J Deary Nicole M Probst-Hensch Holger Schulz Alan L James James F Wilson Beate Stubbe Eleftheria Zeggini Marjo-Riitta Jarvelin Nick Wareham Edwin K Silverman Caroline Hayward Andrew P Morris Adam S Butterworth Robert A Scott Robin G Walters Deborah A Meyers Michael H Cho David P Strachan Ian P Hall Martin D Tobin Louise V Wain

Nat Genet 2019 Jun;51(6):1067

Department of Health Sciences, University of Leicester, Leicester, UK.

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http://dx.doi.org/10.1038/s41588-019-0438-3DOI Listing
June 2019

New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries.

Authors:
Nick Shrine Anna L Guyatt A Mesut Erzurumluoglu Victoria E Jackson Brian D Hobbs Carl A Melbourne Chiara Batini Katherine A Fawcett Kijoung Song Phuwanat Sakornsakolpat Xingnan Li Ruth Boxall Nicola F Reeve Ma'en Obeidat Jing Hua Zhao Matthias Wielscher Stefan Weiss Katherine A Kentistou James P Cook Benjamin B Sun Jian Zhou Jennie Hui Stefan Karrasch Medea Imboden Sarah E Harris Jonathan Marten Stefan Enroth Shona M Kerr Ida Surakka Veronique Vitart Terho Lehtimäki Richard J Allen Per S Bakke Terri H Beaty Eugene R Bleecker Yohan Bossé Corry-Anke Brandsma Zhengming Chen James D Crapo John Danesh Dawn L DeMeo Frank Dudbridge Ralf Ewert Christian Gieger Amund Gulsvik Anna L Hansell Ke Hao Joshua D Hoffman John E Hokanson Georg Homuth Peter K Joshi Philippe Joubert Claudia Langenberg Xuan Li Liming Li Kuang Lin Lars Lind Nicholas Locantore Jian'an Luan Anubha Mahajan Joseph C Maranville Alison Murray David C Nickle Richard Packer Margaret M Parker Megan L Paynton David J Porteous Dmitry Prokopenko Dandi Qiao Rajesh Rawal Heiko Runz Ian Sayers Don D Sin Blair H Smith María Soler Artigas David Sparrow Ruth Tal-Singer Paul R H J Timmers Maarten Van den Berge John C Whittaker Prescott G Woodruff Laura M Yerges-Armstrong Olga G Troyanskaya Olli T Raitakari Mika Kähönen Ozren Polašek Ulf Gyllensten Igor Rudan Ian J Deary Nicole M Probst-Hensch Holger Schulz Alan L James James F Wilson Beate Stubbe Eleftheria Zeggini Marjo-Riitta Jarvelin Nick Wareham Edwin K Silverman Caroline Hayward Andrew P Morris Adam S Butterworth Robert A Scott Robin G Walters Deborah A Meyers Michael H Cho David P Strachan Ian P Hall Martin D Tobin Louise V Wain

Nat Genet 2019 03 25;51(3):481-493. Epub 2019 Feb 25.

Department of Health Sciences, University of Leicester, Leicester, UK.

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http://dx.doi.org/10.1038/s41588-018-0321-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6397078PMC
March 2019

PINES: phenotype-informed tissue weighting improves prediction of pathogenic noncoding variants.

Genome Biol 2018 10 25;19(1):173. Epub 2018 Oct 25.

Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.

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https://genomebiology.biomedcentral.com/articles/10.1186/s13
Publisher Site
http://dx.doi.org/10.1186/s13059-018-1546-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6203199PMC
October 2018

Systematic Cell-Based Phenotyping of Missense Alleles.

Methods Mol Biol 2017 ;1601:215-228

Institute of Human Genetics, University of Heidelberg, Heidelberg, 69120, Germany.

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http://dx.doi.org/10.1007/978-1-4939-6960-9_17DOI Listing
February 2018

The genome as pharmacopeia: association of genetic dose with phenotypic response.

Biochem Pharmacol 2015 Apr 20;94(4):229-40. Epub 2015 Feb 20.

Department of Genetics and Pharmacogenomics, Merck Research Laboratories, Boston, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bcp.2015.02.005DOI Listing
April 2015

Systematic cell-based phenotyping of missense alleles empowers rare variant association studies: a case for LDLR and myocardial infarction.

PLoS Genet 2015 Feb 3;11(2):e1004855. Epub 2015 Feb 3.

Institute of Human Genetics, University of Heidelberg, Heidelberg, Germany; Molecular Medicine Partnership Unit (MMPU), University of Heidelberg/ EMBL, Heidelberg, Germany; Center of Human Genetic Research (CHGR), Massachusetts General Hospital, Boston, Massachusetts, United States of America; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1004855DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4409815PMC
February 2015

Disruption of SOX6 is associated with a rapid-onset dopa-responsive movement disorder, delayed development, and dysmorphic features.

Pediatr Neurol 2015 Jan 17;52(1):115-8. Epub 2014 Sep 17.

Institute of Human Genetics, Ruprecht-Karls-University Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1016/j.pediatrneurol.2014.08.021DOI Listing
January 2015

Transmembrane protein 55B is a novel regulator of cellular cholesterol metabolism.

Arterioscler Thromb Vasc Biol 2014 Sep 17;34(9):1917-23. Epub 2014 Jul 17.

From the Children's Hospital Oakland Research Institute, CA (M.W.M., F.B., D.N., E.T., K.S., R.M.K.); Institute of Human Genetics, University of Heidelberg, Heidelberg, Germany (J.S., H.R.); Sage Bionetworks, Seattle, WA (L.M.M.); Section on Lipid Sciences, Department of Pathology, Wake Forest University Health Sciences, Winston-Salem, NC (L.L.R., R.E.T.); and Molecular Medicine Partnership Unit (MMPU), Heidelberg, Germany (C.S., H.R.).

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http://dx.doi.org/10.1161/ATVBAHA.113.302806DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4141484PMC
September 2014

Disruption of EXOC6B in a patient with developmental delay, epilepsy, and a de novo balanced t(2;8) translocation.

Eur J Hum Genet 2013 Oct 20;21(10):1177-80. Epub 2013 Feb 20.

Division of Human Genetics, Department of Medical Genetics, Molecular and Clinical Pharmacology, Innsbruck Medical University, Innsbruck, Austria.

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http://www.nature.com/articles/ejhg201318
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http://dx.doi.org/10.1038/ejhg.2013.18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3778356PMC
October 2013

Prenatal-onset Niemann-Pick type C disease with nonimmune hydrops fetalis.

Pediatr Neonatol 2013 Oct 11;54(5):344-7. Epub 2013 Mar 11.

Department of Pediatrics, Hacettepe University Faculty of Medicine, Ankara, Turkey; Section of Neonatology, Department of Pediatrics, Hacettepe University Faculty of Medicine, Ankara, Turkey. Electronic address:

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http://dx.doi.org/10.1016/j.pedneo.2013.01.015DOI Listing
October 2013

Low ceruloplasmin in a patient with Niemann-Pick type C disease.

J Clin Neurosci 2012 Apr 24;19(4):620-1. Epub 2012 Jan 24.

Department of Psychiatry and Psychotherapy III, University of Ulm, Leimgrubenweg 12, Ulm 89075, Germany.

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http://dx.doi.org/10.1016/j.jocn.2011.05.038DOI Listing
April 2012

Integrated approaches to functionally characterize novel factors in lipoprotein metabolism.

Authors:
Heiko Runz

Curr Opin Lipidol 2012 Apr;23(2):104-10

Institute of Human Genetics, University of Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1097/MOL.0b013e328350fc3dDOI Listing
April 2012

A deaf mother and son with diabetes and renal failure.

Clin Kidney J 2012 Apr;5(2):137-139

Department of Nephrology and Transplantation Medicine, Westpfalzklinikum Kaiserslautern, Kaiserslautern, Germany.

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http://dx.doi.org/10.1093/ckj/sfs018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5783218PMC
April 2012

Niemann-Pick Type C disease: characterizing lipid levels in patients with variant lysosomal cholesterol storage.

J Lipid Res 2011 Apr 17;52(4):813-25. Epub 2011 Jan 17.

Institute of Human Genetics, University of Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1194/jlr.P013524DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3284170PMC
April 2011

Genetic analysis of BIRC4/XIAP as a putative modifier gene of Wilson disease.

J Inherit Metab Dis 2010 Dec 2;33 Suppl 3:S233-40. Epub 2010 Jun 2.

Department of Gastroenterology, University Hospital Heidelberg, INF 410, 69120 Heidelberg, Germany.

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http://dx.doi.org/10.1007/s10545-010-9123-5DOI Listing
December 2010

Exosome secretion ameliorates lysosomal storage of cholesterol in Niemann-Pick type C disease.

J Biol Chem 2010 Aug 16;285(34):26279-88. Epub 2010 Jun 16.

Max-Planck-Institute for Experimental Medicine, Goettingen, Germany.

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http://dx.doi.org/10.1074/jbc.M110.134775DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2924046PMC
August 2010

DetecTiff: a novel image analysis routine for high-content screening microscopy.

J Biomol Screen 2009 Sep 29;14(8):944-55. Epub 2009 Jul 29.

Cell Biology/Biophysics Unit, EMBL, Heidelberg, Germany.

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http://dx.doi.org/10.1177/1087057109339523DOI Listing
September 2009

Identification of cholesterol-regulating genes by targeted RNAi screening.

Cell Metab 2009 Jul;10(1):63-75

Institute of Human Genetics, University of Heidelberg, Seminarstrasse 2, Heidelberg, Germany.

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http://dx.doi.org/10.1016/j.cmet.2009.05.009DOI Listing
July 2009

NPC-db, a Niemann-Pick type C disease gene variation database.

Hum Mutat 2008 Mar;29(3):345-50

Institute of Human Genetics, University of Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1002/humu.20636DOI Listing
March 2008

Sterols regulate ER-export dynamics of secretory cargo protein ts-O45-G.

EMBO J 2006 Jul 22;25(13):2953-65. Epub 2006 Jun 22.

Cell Biology & Cell Biophysics Programme, European Molecular Biology Laboratory, EMBL, Heidelberg, Germany.

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http://dx.doi.org/10.1038/sj.emboj.7601205DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1500972PMC
July 2006