Heiko Bugger

Heiko Bugger

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Heiko Bugger

Heiko Bugger

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Electro-mechanical (dys-)function in long QT syndrome type 1.

Int J Cardiol 2019 Jan 9;274:144-151. Epub 2018 Jul 9.

Department of Cardiology and Angiology I, Heart Center, University of Freiburg, Freiburg, Germany; Faculty of Medicine, University of Freiburg, Freiburg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.ijcard.2018.07.050DOI Listing
January 2019

Mitochondrial Reactive Oxygen Species in Lipotoxic Hearts Induce Post-Translational Modifications of AKAP121, DRP1, and OPA1 That Promote Mitochondrial Fission.

Circ Res 2018 Jan 1;122(1):58-73. Epub 2017 Nov 1.

From the Division of Endocrinology and Metabolism, Fraternal Order of Eagles Diabetes Research Center, Roy J. and Lucille A. Carver College of Medicine (K.T., J.S., G.A.J., A.R.T., R.M., H.C.K., Y.Z., R.S., R.O.P., E.D.A.) and Department of Health and Human Physiology (V.A.L.), University of Iowa, Iowa City; Division of Endocrinology, Metabolism, and Diabetes and Program in Molecular Medicine (K.T., H.B., A.R.W., J.S., X.X.H., C.L.S., E.D.A.), Nora Eccles Harrison Cardiovascular Research and Training Institute (K.W.S.), and Department of Biochemistry (O.K.), University of Utah School of Medicine, Salt Lake City; Cardiology and Angiology I (H.B.) and Institute for Experimental Cardiovascular Medicine (E.A.R.-Z., P.K.), Heart Center Freiburg University, and Faculty of Medicine (H.B., E.A.R.-Z., P.K.), University of Freiburg, Germany; Division of Molecular and Cellular Pathology, Department of Pathology, University of Alabama at Birmingham (A.R.W.); Department of Radiology (T.L.S., K.I.S.) and Diabetic Cardiovascular Disease Center, Cardiovascular Division (J.E.S.), Washington University School of Medicine, St. Louis, MO; Division of Cardiology, Department of Medicine, University of Colorado Anschutz Medical Center, Aurora (G.C.S.); and Department of Biochemistry and Nebraska Redox Biology Center, University of Nebraska, Lincoln (O.K.).

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https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.117.31130
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http://dx.doi.org/10.1161/CIRCRESAHA.117.311307DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5756120PMC
January 2018

Interregional electro-mechanical heterogeneity in the rabbit myocardium.

Prog Biophys Mol Biol 2017 11 24;130(Pt B):344-355. Epub 2017 Jun 24.

Department of Cardiology and Angiology I, Heart Center University of Freiburg, Hugstetter Strasse 55, 79106 Freiburg, Germany; Faculty of Medicine, University of Freiburg, Breisacher Strasse 153, 79110 Freiburg, Germany; Institute for Experimental Cardiovascular Medicine, Heart Center University of Freiburg, Medical Center - University of Freiburg, Elsaesserstrasse 2q, 79110 Freiburg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.pbiomolbio.2017.06.016DOI Listing
November 2017

Phase-contrast magnet resonance imaging reveals regional, transmural, and base-to-apex dispersion of mechanical dysfunction in patients with long QT syndrome.

Heart Rhythm 2017 09 4;14(9):1388-1397. Epub 2017 May 4.

Department of Cardiology and Angiology I, Heart Center, University of Freiburg, Freiburg, Germany; Faculty of Medicine, University of Freiburg, Freiburg, Germany; Institute for Experimental Cardiovascular Medicine, Heart Center, University of Freiburg, Freiburg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.hrthm.2017.04.045DOI Listing
September 2017

Diabetic Cardiomyopathy: Does the Type of Diabetes Matter?

Int J Mol Sci 2016 Dec 18;17(12). Epub 2016 Dec 18.

Cardiology and Angiology I, University Heart Center Freiburg, Hugstetter Str. 55, 79106 Freiburg, Germany.

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http://dx.doi.org/10.3390/ijms17122136DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5187936PMC
December 2016

SIRT3 in Cardiac Physiology and Disease.

Front Cardiovasc Med 2016 13;3:38. Epub 2016 Oct 13.

Division of Cardiology and Angiology I, Heart Center Freiburg University , Freiburg , Germany.

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http://dx.doi.org/10.3389/fcvm.2016.00038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5061741PMC
October 2016

Mitochondrial sirtuins in the heart.

Heart Fail Rev 2016 09;21(5):519-28

Department of Cardiology and Angiology I, Heart Center Freiburg University, Hugstetter Str. 55, 79106, Freiburg, Germany.

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http://dx.doi.org/10.1007/s10741-016-9570-7DOI Listing
September 2016

Mechanisms of acquired long QT syndrome in patients with propionic academia.

Heart Rhythm 2016 06 27;13(6):1335-45. Epub 2016 Feb 27.

Department of Cardiology and Angiology I, Heart Center University of Freiburg, Freiburg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.hrthm.2016.02.003DOI Listing
June 2016

SIRT3 deficiency impairs mitochondrial and contractile function in the heart.

Basic Res Cardiol 2015 12;110(4):36. Epub 2015 May 12.

Division of Cardiology and Angiology I, Heart Center Freiburg University, Hugstetter Str. 55, 79106, Freiburg, Germany.

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http://dx.doi.org/10.1007/s00395-015-0493-6DOI Listing
February 2016

Preserved recovery of cardiac function following ischemia-reperfusion in mice lacking SIRT3.

Can J Physiol Pharmacol 2016 Jan 19;94(1):72-80. Epub 2015 Jul 19.

a Division of Cardiology and Angiology I, Heart Center Freiburg University, Freiburg, Germany.

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http://www.nrcresearchpress.com/doi/10.1139/cjpp-2015-0152
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http://dx.doi.org/10.1139/cjpp-2015-0152DOI Listing
January 2016

Adrenergic Repression of the Epigenetic Reader MeCP2 Facilitates Cardiac Adaptation in Chronic Heart Failure.

Circ Res 2015 Sep 20;117(7):622-33. Epub 2015 Jul 20.

From the Institute of Experimental and Clinical Pharmacology and Toxicology (S.C.M., R.G., S.P., E.B.M.O., T.S., N.B., A.L., C.R., H.I., J.O., K.A., L.H.), Hermann-Staudinger-Graduiertenschule (S.P.), University Heart Center Freiburg-Bad Krozingen (T.S., A.L., H.B., C.H., F.B., C.B., B.S.), Department of Medicine IV, Nephrology and Primary Care, Medical Center (J.W.), Institute of Anatomy and Cell Biology (O.K.), Renal Division, University Clinic Freiburg (O.K.), Medical Physics (D.E.), and BIOSS Centre for Biological Signalling Studies (L.H.), University of Freiburg, Freiburg, Germany; Department of Molecular Biology, UT Southwestern Medical Center at Dallas, TX (N.B.); Department of Genetic Epidemiology, Institute of Human Genetics, University of Münster, Münster, Germany (F.R., M.S.); Department of Cardiothoracic Surgery, Jena University Hospital, Friedrich Schiller University of Jena, Jena, Germany (A.S., M.S., T.D.); Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany (U.B.); Institute of Molecular and Translational Therapeutic Strategies (IMTTS), IFB-Tx (S.K.G., T.T.) and REBIRTH Excellence Cluster (T.T.), Hannover Medical School, Hannover, Germany; Max-Planck-Institut für Herz- und Lungenforschung, Bad Nauheim, Germany (M.K.); and National Heart and Lung Institute, Imperial College, London, United Kingdom (T.T.).

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http://circres.ahajournals.org/content/early/2015/07/20/CIRC
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http://circres.ahajournals.org/lookup/doi/10.1161/CIRCRESAHA
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http://dx.doi.org/10.1161/CIRCRESAHA.115.306721DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4568894PMC
September 2015

Antioxidant treatment normalizes mitochondrial energetics and myocardial insulin sensitivity independently of changes in systemic metabolic homeostasis in a mouse model of the metabolic syndrome.

J Mol Cell Cardiol 2015 Aug 22;85:104-16. Epub 2015 May 22.

Division of Endocrinology, Metabolism, and Diabetes, Program in Molecular Medicine, University of Utah School of Medicine, Salt Lake City, UT 84112, USA; Fraternal Order of Eagles Diabetes Research Center, Division of Endocrinology and Metabolism, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00222828150016
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http://dx.doi.org/10.1016/j.yjmcc.2015.05.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4530070PMC
August 2015

Mitochondrial Mechanisms in Septic Cardiomyopathy.

Int J Mol Sci 2015 Aug 3;16(8):17763-78. Epub 2015 Aug 3.

Department of Cardiology and Angiology, Heart Center Freiburg University, Hugstetter Str. 55, 79106 Freiburg, Germany.

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http://dx.doi.org/10.3390/ijms160817763DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4581220PMC
August 2015

Enhanced cardiac Akt/protein kinase B signaling contributes to pathological cardiac hypertrophy in part by impairing mitochondrial function via transcriptional repression of mitochondrion-targeted nuclear genes.

Mol Cell Biol 2015 Mar 22;35(5):831-46. Epub 2014 Dec 22.

Program in Molecular Medicine and Division of Endocrinology, Metabolism, and Diabetes, University of Utah, School of Medicine, Salt Lake City, Utah, USA Fraternal Order of Eagles Diabetes Research Center and Division of Endocrinology and Metabolism, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA

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http://dx.doi.org/10.1128/MCB.01109-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4323486PMC
March 2015

Molecular mechanisms of diabetic cardiomyopathy.

Diabetologia 2014 Apr 30;57(4):660-71. Epub 2014 Jan 30.

Cardiology and Angiology I, Heart Center Freiburg University, Freiburg, Germany.

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http://dx.doi.org/10.1007/s00125-014-3171-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3969857PMC
April 2014

Mechanistic target of rapamycin (Mtor) is essential for murine embryonic heart development and growth.

PLoS One 2013 14;8(1):e54221. Epub 2013 Jan 14.

Division of Endocrinology, Metabolism, and Diabetes and Program in Molecular Medicine, School of Medicine, University of Utah, Salt Lake City, Utah, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0054221PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3544830PMC
August 2013

Diabetes mellitus and myocardial mitochondrial dysfunction: bench to bedside.

Heart Fail Clin 2012 Oct 9;8(4):551-61. Epub 2012 Aug 9.

Department of Cardiology and Angiology, University Hospital of Freiburg, Hugstetter Strasse 55, Freiburg, Germany.

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http://dx.doi.org/10.1016/j.hfc.2012.06.001DOI Listing
October 2012

Genetic loss of insulin receptors worsens cardiac efficiency in diabetes.

J Mol Cell Cardiol 2012 May 9;52(5):1019-26. Epub 2012 Feb 9.

Division of Endocrinology, Metabolism and Diabetes, University of Utah School of Medicine, Salt Lake City, UT 84112, USA.

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http://dx.doi.org/10.1016/j.yjmcc.2012.02.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3327790PMC
May 2012

Endonuclease G: the link between mitochondria and cardiac hypertrophy?

Circ Res 2012 Feb;110(3):378-80

Division of Cardiology, University of Freiburg, Germany.

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http://dx.doi.org/10.1161/RES.0b013e318249dcc8DOI Listing
February 2012

Uncoupling protein downregulation in doxorubicin-induced heart failure improves mitochondrial coupling but increases reactive oxygen species generation.

Cancer Chemother Pharmacol 2011 Jun 31;67(6):1381-8. Epub 2010 Aug 31.

Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, 333 Cedar Street, FMP 3, New Haven, CT 06520, USA.

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http://link.springer.com/10.1007/s00280-010-1441-7
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http://dx.doi.org/10.1007/s00280-010-1441-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3051028PMC
June 2011

Mitochondria in the diabetic heart.

Cardiovasc Res 2010 Nov 16;88(2):229-40. Epub 2010 Jul 16.

Department of Cardiology, University of Freiburg, Freiburg, Germany.

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http://dx.doi.org/10.1093/cvr/cvq239DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2952534PMC
November 2010

Rodent models of diabetic cardiomyopathy.

Dis Model Mech 2009 Sep-Oct;2(9-10):454-66

Division of Endocrinology, Metabolism and Diabetes, and Program in Molecular Medicine, University of Utah School of Medicine, Salt Lake City, UT 84132, USA.

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http://dx.doi.org/10.1242/dmm.001941DOI Listing
January 2010

Proteomic remodelling of mitochondrial oxidative pathways in pressure overload-induced heart failure.

Cardiovasc Res 2010 Jan 19;85(2):376-84. Epub 2009 Oct 19.

Department of Cardiac Surgery, University of Leipzig Heart Center, Strümpellstr 39, Leipzig 04289, Germany.

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https://academic.oup.com/cardiovascres/article-lookup/doi/10
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http://dx.doi.org/10.1093/cvr/cvp344DOI Listing
January 2010

Insulin signaling regulates mitochondrial function in pancreatic beta-cells.

PLoS One 2009 Nov 24;4(11):e7983. Epub 2009 Nov 24.

Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0007983PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2776992PMC
November 2009

Tissue-specific remodeling of the mitochondrial proteome in type 1 diabetic akita mice.

Diabetes 2009 Sep 19;58(9):1986-97. Epub 2009 Jun 19.

Division of Endocrinology, Metabolism and Diabetes, and Program in Molecular Medicine, University of Utah School of Medicine, Salt Lake City, Utah, USA.

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http://diabetes.diabetesjournals.org/cgi/doi/10.2337/db09-02
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http://dx.doi.org/10.2337/db09-0259DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2731527PMC
September 2009

Type 1 diabetic akita mouse hearts are insulin sensitive but manifest structurally abnormal mitochondria that remain coupled despite increased uncoupling protein 3.

Diabetes 2008 Nov 4;57(11):2924-32. Epub 2008 Aug 4.

Division of Endocrinology, Metabolism, and Diabetes, Program in Human Molecular Biology and Genetics, University of Utah School of Medicine, Salt Lake City, Utah, USA.

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http://dx.doi.org/10.2337/db08-0079DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2570388PMC
November 2008

Three good reasons for heart surgeons to understand cardiac metabolism.

Eur J Cardiothorac Surg 2008 May 18;33(5):862-71. Epub 2008 Mar 18.

Department of Cardiac Surgery, University of Leipzig Heart Center, Strümpellstr. 39, 04289 Leipzig, Germany.

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http://dx.doi.org/10.1016/j.ejcts.2008.02.015DOI Listing
May 2008

Molecular mechanisms for myocardial mitochondrial dysfunction in the metabolic syndrome.

Clin Sci (Lond) 2008 Feb;114(3):195-210

Division of Endocrinology, Metabolism and Diabetes, Program in Human Molecular Biology and Genetics, University of Utah School of Medicine, Salt Lake City, UT 84112, USA.

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http://clinsci.org/lookup/doi/10.1042/CS20070166
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http://dx.doi.org/10.1042/CS20070166DOI Listing
February 2008

Mitochondrial energetics in the heart in obesity-related diabetes: direct evidence for increased uncoupled respiration and activation of uncoupling proteins.

Diabetes 2007 Oct 10;56(10):2457-66. Epub 2007 Jul 10.

Division of Endocrinology, Metabolism, and Diabetes, Program in Human Molecular Biology and Genetics, University of Utah School of Medicine, Salt Lake City, Utah 84112, USA.

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http://dx.doi.org/10.2337/db07-0481DOI Listing
October 2007

Subtractive hybridization for differential gene expression in mechanically unloaded rat heart.

Am J Physiol Heart Circ Physiol 2006 Dec 9;291(6):H2714-22. Epub 2006 Jun 9.

Dept. of Cardiovascular Surgery, University of Freiburg, Germany.

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http://www.physiology.org/doi/10.1152/ajpheart.00445.2005
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http://dx.doi.org/10.1152/ajpheart.00445.2005DOI Listing
December 2006

Differential changes in respiratory capacity and ischemia tolerance of isolated mitochondria from atrophied and hypertrophied hearts.

Metabolism 2006 Aug;55(8):1097-106

Department of Cardiovascular Surgery, Albert-Ludwigs University of Freiburg, 79106 Freiburg i. Br., Germany.

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http://linkinghub.elsevier.com/retrieve/pii/S002604950600139
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http://dx.doi.org/10.1016/j.metabol.2006.04.005DOI Listing
August 2006