Publications by authors named "Heikki Ruskoaho"

100Publications

GATA4-targeted compound exhibits cardioprotective actions against doxorubicin-induced toxicity in vitro and in vivo: establishment of a chronic cardiotoxicity model using human iPSC-derived cardiomyocytes.

Arch Toxicol 2020 06 17;94(6):2113-2130. Epub 2020 Mar 17.

Drug Research Program and Division of Pharmacology and Pharmacotherapy, Faculty of Pharmacy, University of Helsinki, P.O. Box 56, 00014, Helsinki, Finland.

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http://dx.doi.org/10.1007/s00204-020-02711-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7303099PMC
June 2020

Phosphorylation of GATA4 at serine 105 is required for left ventricular remodelling process in angiotensin II-induced hypertension in rats.

Basic Clin Pharmacol Toxicol 2020 Sep 9;127(3):178-195. Epub 2020 Mar 9.

Drug Research Program, Division of Pharmacology and Pharmacotherapy, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1111/bcpt.13398DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7496669PMC
September 2020

Fabrication and Characterization of Drug-Loaded Conductive Poly(glycerol sebacate)/Nanoparticle-Based Composite Patch for Myocardial Infarction Applications.

ACS Appl Mater Interfaces 2020 Feb 3;12(6):6899-6909. Epub 2020 Feb 3.

Drug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy , University of Helsinki , FI-00014 Helsinki , Finland.

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http://dx.doi.org/10.1021/acsami.9b21066DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7450488PMC
February 2020

Dual-peptide functionalized acetalated dextran-based nanoparticles for sequential targeting of macrophages during myocardial infarction.

Nanoscale 2020 Jan 13;12(4):2350-2358. Epub 2020 Jan 13.

Drug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, FI-00014 Helsinki, Finland. and Helsinki Institute of Life Science, HiLIFE, University of Helsinki, FI-00014 Helsinki, Finland.

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http://dx.doi.org/10.1039/c9nr09934dDOI Listing
January 2020

Heat shock protein 90 is downregulated in calcific aortic valve disease.

BMC Cardiovasc Disord 2019 12 19;19(1):306. Epub 2019 Dec 19.

School of Pharmacy, University of Eastern Finland, POB 1627, 70211, Kuopio, Finland.

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http://dx.doi.org/10.1186/s12872-019-01294-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6923932PMC
December 2019

A novel dual reporter embryonic stem cell line for toxicological assessment of teratogen-induced perturbation of anterior-posterior patterning of the heart.

Arch Toxicol 2020 02 6;94(2):631-645. Epub 2019 Dec 6.

Division of Pharmacology and Pharmacotherapy, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1007/s00204-019-02632-1DOI Listing
February 2020

Synthesis, Identification, and Structure-Activity Relationship Analysis of GATA4 and NKX2-5 Protein-Protein Interaction Modulators.

J Med Chem 2019 09 3;62(17):8284-8310. Epub 2019 Sep 3.

Imperial College London, Imperial Centre for Translational and Experimental Medicine , National Heart and Lung Institute , Du Cane Road , London W12 0NN , United Kingdom.

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http://dx.doi.org/10.1021/acs.jmedchem.9b01086DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7076710PMC
September 2019

Targeting GATA4 for cardiac repair.

IUBMB Life 2020 01 16;72(1):68-79. Epub 2019 Aug 16.

Drug Research Program, Division of Pharmacology and Pharmacotherapy, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1002/iub.2150DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6973159PMC
January 2020

Inhibition of Regulates Cardiac Regeneration after Cryoinjury in Adult Zebrafish.

J Cardiovasc Dev Dis 2019 Apr 4;6(2). Epub 2019 Apr 4.

Unit of Cardiovascular Research, Minerva Institute for Medical Research, Biomedicum Helsinki, 00290 Helsinki, Finland.

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https://www.mdpi.com/2308-3425/6/2/16
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http://dx.doi.org/10.3390/jcdd6020016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6617397PMC
April 2019

Cellular Internalization-Induced Aggregation of Porous Silicon Nanoparticles for Ultrasound Imaging and Protein-Mediated Protection of Stem Cells.

Small 2019 01 28;15(1):e1804332. Epub 2018 Nov 28.

Department of Pharmaceutical Science Laboratory, Åbo Akademi University, Turku, 20520, Finland.

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http://dx.doi.org/10.1002/smll.201804332DOI Listing
January 2019

Molecular Atlas of Postnatal Mouse Heart Development.

J Am Heart Assoc 2018 10;7(20):e010378

1 Drug Research Program and Division of Pharmacology and Pharmacotherapy Faculty of Pharmacy University of Helsinki Finland.

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http://dx.doi.org/10.1161/JAHA.118.010378DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6474944PMC
October 2018

Cellular Mechanisms of Valvular Thickening in Early and Intermediate Calcific Aortic Valve Disease.

Curr Cardiol Rev 2018 ;14(4):264-271

School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, 70211 Kuopio, Finland.

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http://dx.doi.org/10.2174/1573403X14666180820151325DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6300797PMC
November 2018

Stem cells are the most sensitive screening tool to identify toxicity of GATA4-targeted novel small-molecule compounds.

Arch Toxicol 2018 09 9;92(9):2897-2911. Epub 2018 Jul 9.

Drug Research Program and Division of Pharmacology and Pharmacotherapy, Faculty of Pharmacy, University of Helsinki, P.O. Box 56, 00014, Helsinki, Finland.

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http://dx.doi.org/10.1007/s00204-018-2257-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6132687PMC
September 2018

Mechanical stretch induced transcriptomic profiles in cardiac myocytes.

Sci Rep 2018 03 16;8(1):4733. Epub 2018 Mar 16.

Research Unit of Biomedicine, Pharmacology and Toxicology, University of Oulu, Oulu, Finland.

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http://dx.doi.org/10.1038/s41598-018-23042-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5856749PMC
March 2018

SDF1 gradient associates with the distribution of c-Kit+ cardiac cells in the heart.

Sci Rep 2018 01 18;8(1):1160. Epub 2018 Jan 18.

Biocenter Oulu, Faculty of Biochemistry and Molecular Medicine, Oulu Center for Cell-Matrix Research, University of Oulu, Oulu, Finland.

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http://dx.doi.org/10.1038/s41598-018-19417-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5773575PMC
January 2018

Discovery of Small Molecules Targeting the Synergy of Cardiac Transcription Factors GATA4 and NKX2-5.

J Med Chem 2017 09 15;60(18):7781-7798. Epub 2017 Sep 15.

Division of Pharmacology and Pharmacotherapy, Faculty of Pharmacy, University of Helsinki , Helsinki FI-00014, Finland.

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http://dx.doi.org/10.1021/acs.jmedchem.7b00816DOI Listing
September 2017

Transcription factor PEX1 modulates extracellular matrix turnover through regulation of MMP-9 expression.

Cell Tissue Res 2017 02 8;367(2):369-385. Epub 2016 Nov 8.

Department of Pharmacology and Toxicology, Research Unit of Biomedicine, Faculty of Medicine, University of Oulu, POB 5000, 90014, Oulu, Finland.

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http://dx.doi.org/10.1007/s00441-016-2527-2DOI Listing
February 2017

Targeting vasoactive peptides for managing calcific aortic valve disease.

Ann Med 2017 02 3;49(1):63-74. Epub 2016 Nov 3.

c School of Pharmacy, Faculty of Health Sciences , University of Eastern Finland , Finland.

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http://dx.doi.org/10.1080/07853890.2016.1231933DOI Listing
February 2017

Cardiac fibrosis in myocardial infarction-from repair and remodeling to regeneration.

Cell Tissue Res 2016 09 21;365(3):563-81. Epub 2016 Jun 21.

Division of Pharmacology and Pharmacotherapy, Faculty of Pharmacy, University of Helsinki, P.O. Box 56, FI-00014, Helsinki, Finland.

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http://dx.doi.org/10.1007/s00441-016-2431-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5010608PMC
September 2016

In vitro and in vivo assessment of heart-homing porous silicon nanoparticles.

Biomaterials 2016 07 11;94:93-104. Epub 2016 Apr 11.

Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, FI-00014 Helsinki, Finland. Electronic address:

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http://dx.doi.org/10.1016/j.biomaterials.2016.03.046DOI Listing
July 2016

Neoplastic extracellular matrix environment promotes cancer invasion in vitro.

Exp Cell Res 2016 06 20;344(2):229-40. Epub 2016 Apr 20.

Cancer and Translational Medicine Research Unit, University of Oulu, PO Box 5281, Aapistie 5A, FIN 90014 Oulu, Finland; Medical Research Center, Oulu University Hospital, Oulu, Finland; Department of Oral and Maxillofacial Diseases, University of Helsinki, and HUSLAB, Helsinki, Finland.

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http://dx.doi.org/10.1016/j.yexcr.2016.04.003DOI Listing
June 2016

[Role of reactive oxygen species in the regulation of cardiac function].

Orv Hetil 2015 Nov;156(47):1912-5

Szívgyógyászati Klinika, Pécsi Tudományegyetem, Általános Orvostudományi Kar, Klinikai Központ Pécs, Ifjúság útja 13., 7624.

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http://dx.doi.org/10.1556/650.2015.30303DOI Listing
November 2015

Effect of vasoactive peptides in Tetrahymena: chemotactic activities of adrenomedullin, proadrenomedullin N-terminal 20 peptide (PAMP) and calcitonin gene-related peptide (CGRP).

Mol Cell Biochem 2016 Jan 19;411(1-2):271-80. Epub 2015 Oct 19.

Division of Pharmacology and Pharmcotherapy, University of Helsinki, P.O.Box 56, 00014, Helsinki, Finland.

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http://dx.doi.org/10.1007/s11010-015-2589-6DOI Listing
January 2016

TSC-22 up-regulates collagen 3a1 gene expression in the rat heart.

BMC Cardiovasc Disord 2015 Oct 13;15:122. Epub 2015 Oct 13.

Research Unit of Biomedicine (Pharmacology & Toxicology), University of Oulu, Oulu, Finland.

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http://dx.doi.org/10.1186/s12872-015-0121-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4604760PMC
October 2015

MicroRNA-125b and chemokine CCL4 expression are associated with calcific aortic valve disease.

Ann Med 2015 30;47(5):423-9. Epub 2015 Jul 30.

a Institute of Biomedicine, Department of Pharmacology and Toxicology , University of Oulu , Oulu , Finland.

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http://dx.doi.org/10.3109/07853890.2015.1059955DOI Listing
January 2016

Inhibition of Let-7 microRNA attenuates myocardial remodeling and improves cardiac function postinfarction in mice.

Pharmacol Res Perspect 2014 Aug 12;2(4):e00056. Epub 2014 Jun 12.

Department of Pharmacology and Toxicology, Institute of Biomedicine, University of Oulu Oulu, Finland ; Biocenter Oulu, Faculty of Biochemistry and Molecular Medicine, University of Oulu Oulu, Finland.

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http://dx.doi.org/10.1002/prp2.56DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4186442PMC
August 2014

Bone morphogenetic protein-2--a potential autocrine/paracrine factor in mediating the stretch activated B-type and atrial natriuretic peptide expression in cardiac myocytes.

Mol Cell Endocrinol 2015 Jan 10;399:9-21. Epub 2014 Sep 10.

Department of Pharmacology and Toxicology, Institute of Biomedicine, University of Oulu, P.O. BOX 5000, Oulu FI-90014, Finland; Division of Pharmacology and Pharmacotherapy, Faculty of Pharmacy, University of Helsinki, P.O. BOX 56, Viikinkaari 5E, Helsinki FI-00014, Finland. Electronic address:

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http://dx.doi.org/10.1016/j.mce.2014.09.003DOI Listing
January 2015

Advanced Nanomedicines for the Treatment and Diagnosis of Myocardial Infarction and Heart Failure.

Curr Drug Targets 2015 ;16(14):1682-97

Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, FI-00014 Helsinki, Finland.

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http://dx.doi.org/10.2174/1389450115999141030143923DOI Listing
September 2016

Characterization of the regulatory mechanisms of activating transcription factor 3 by hypertrophic stimuli in rat cardiomyocytes.

PLoS One 2014 19;9(8):e105168. Epub 2014 Aug 19.

Department of Pharmacology and Toxicology, Institute of Biomedicine, University of Oulu, Oulu, Finland; School of Pharmacy, University of Eastern Finland, Kuopio, Finland.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0105168PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4138181PMC
May 2015

In vivo biocompatibility of porous silicon biomaterials for drug delivery to the heart.

Biomaterials 2014 Sep 28;35(29):8394-405. Epub 2014 Jun 28.

Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, FI-00014 Helsinki, Finland. Electronic address:

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http://dx.doi.org/10.1016/j.biomaterials.2014.05.078DOI Listing
September 2014

Plasma B-type natriuretic peptide (BNP) in acute Puumala hantavirus infection.

Ann Med 2014 Feb 6;46(1):38-43. Epub 2014 Jan 6.

Institute of Diagnostics, Department of Medical Microbiology, University of Oulu , Oulu , Finland.

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http://dx.doi.org/10.3109/07853890.2013.862960DOI Listing
February 2014

p38α regulates SERCA2a function.

J Mol Cell Cardiol 2014 Feb 17;67:86-93. Epub 2013 Dec 17.

Dept. of Pharmacology and Toxicology, Institute of Biomedicine, University of Oulu, P.O. BOX 5000, FI-90014 Oulu, Finland; Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Finland. Electronic address:

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http://dx.doi.org/10.1016/j.yjmcc.2013.12.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4296568PMC
February 2014

Thrombospondins, potential drug targets for cardiovascular diseases.

Basic Clin Pharmacol Toxicol 2013 Jan;112(1):4-12

Department of Pharmacology and Toxicology, Institute of Biomedicine, Biocenter Oulu, University of Oulu, FIN-90014 Oulu, Finland.

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http://dx.doi.org/10.1111/bcpt.12026DOI Listing
January 2013

Tezosentan inhibits uptake of proinflammatory endothelin-1 in stenotic aortic valves.

J Heart Valve Dis 2012 Jan;21(1):23-30

Institute of Biomedicine, Department of Anatomy, University of Oulu, Surgery Clinic, Oulu University Hospital, Finland.

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January 2012

Thrombospondin-4, tumour necrosis factor-like weak inducer of apoptosis (TWEAK) and its receptor Fn14: novel extracellular matrix modulating factors in cardiac remodelling.

Ann Med 2012 Dec 1;44(8):793-804. Epub 2012 Mar 1.

Institute of Biomedicine, Department of Pharmacology and Toxicology, Biocenter Oulu, University of Oulu, Oulu, Finland.

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http://dx.doi.org/10.3109/07853890.2011.614635DOI Listing
December 2012

Statin treatment and gene expression of anti-atherogenic factor C-type natriuretic peptide system in stenotic aortic valves.

J Heart Valve Dis 2011 Sep;20(5):545-51

Institution of Biomedicine, Department of Pharmacology and Toxicology, Biocenter Oulu, University of Oulu, Finland.

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September 2011

Increased thrombospondin-2 in human fibrosclerotic and stenotic aortic valves.

Atherosclerosis 2012 Jan 12;220(1):66-71. Epub 2011 Oct 12.

Department of Pharmacology and Toxicology, Institute of Biomedicine, University of Oulu, Biocenter Oulu, Oulu, Finland.

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http://dx.doi.org/10.1016/j.atherosclerosis.2011.10.003DOI Listing
January 2012

M-CAT element mediates mechanical stretch-activated transcription of B-type natriuretic peptide via ERK activation.

Can J Physiol Pharmacol 2011 Aug 3;89(8):539-50. Epub 2011 Aug 3.

Institute of Biomedicine, Department of Pharmacology and Toxicology, Biocenter Oulu, University of Oulu, Oulu FIN-90014, Finland.

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http://www.nrcresearchpress.com/doi/10.1139/y11-049
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http://dx.doi.org/10.1139/y11-049DOI Listing
August 2011

Left ventricular periostin gene expression is associated with fibrogenesis in experimental renal insufficiency.

Nephrol Dial Transplant 2012 Jan 28;27(1):115-22. Epub 2011 Jun 28.

Department of Pharmacology and Toxicology, Institute of Biomedicine, University of Oulu, Biocentre Oulu, Oulu, Finland.

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http://ndt.oxfordjournals.org/content/27/1/115.full.pdf
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http://ndt.oxfordjournals.org/cgi/doi/10.1093/ndt/gfr279
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http://dx.doi.org/10.1093/ndt/gfr279DOI Listing
January 2012

BMP-4 expression has prognostic significance in advanced serous ovarian carcinoma and is affected by cisplatin in OVCAR-3 cells.

Tumour Biol 2011 Oct 15;32(5):985-95. Epub 2011 Jun 15.

Department of Obstetrics and Gynecology, University of Oulu, 90014, Oulu, Finland.

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http://dx.doi.org/10.1007/s13277-011-0200-7DOI Listing
October 2011

Intramyocardial BNP gene delivery improves cardiac function through distinct context-dependent mechanisms.

Circ Heart Fail 2011 Jul 10;4(4):483-95. Epub 2011 May 10.

Institute of Biomedicine, Department of Pharmacology and Toxicology, Biocenter Oulu, Oulu, Finland.

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http://dx.doi.org/10.1161/CIRCHEARTFAILURE.110.958033DOI Listing
July 2011

Distinct regulation of B-type natriuretic peptide transcription by p38 MAPK isoforms.

Mol Cell Endocrinol 2011 May 24;338(1-2):18-27. Epub 2011 Feb 24.

Institute of Biomedicine, Department of Pharmacology and Toxicology, University of Oulu, Oulu, Finland.

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https://linkinghub.elsevier.com/retrieve/pii/S03037207110015
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http://dx.doi.org/10.1016/j.mce.2011.02.015DOI Listing
May 2011

Role of reactive oxygen species in the regulation of cardiac contractility.

J Mol Cell Cardiol 2011 May 21;50(5):884-93. Epub 2011 Feb 21.

Institute of Biomedicine, Department of Pharmacology and Toxicology, Biocenter Oulu, University of Oulu, Oulu, Finland.

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http://dx.doi.org/10.1016/j.yjmcc.2011.02.005DOI Listing
May 2011

(Pro)renin receptors and angiotensin converting enzyme 2/angiotensin-(1-7)/Mas receptor axis in human aortic valve stenosis.

Atherosclerosis 2011 May 21;216(1):35-43. Epub 2011 Jan 21.

Department of Pharmacology and Toxicology, Biocenter Oulu, Institute of Biomedicine, University of Oulu, Oulu, Finland.

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http://dx.doi.org/10.1016/j.atherosclerosis.2011.01.018DOI Listing
May 2011

Key roles of endothelin-1 and p38 MAPK in the regulation of atrial stretch response.

Am J Physiol Regul Integr Comp Physiol 2011 Jan 17;300(1):R140-9. Epub 2010 Nov 17.

Institute of Biomedicine, Department of Pharmacology and Toxicology, University of Oulu, Finland.

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http://dx.doi.org/10.1152/ajpregu.00853.2009DOI Listing
January 2011

Characterization of molecular forms of N-terminal B-type natriuretic peptide in vitro.

Clin Chem 2010 Dec 6;56(12):1822-9. Epub 2010 Oct 6.

Department of Physiology, Institute of Biomedicine, Biocenter Oulu, University of Oulu, Oulu, Finland.

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http://dx.doi.org/10.1373/clinchem.2010.148775DOI Listing
December 2010

Vascular endothelial growth factor-B gene transfer prevents angiotensin II-induced diastolic dysfunction via proliferation and capillary dilatation in rats.

Cardiovasc Res 2011 Jan 23;89(1):204-13. Epub 2010 Aug 23.

Department of Pharmacology and Toxicology, Biocenter Oulu, Institute of Biomedicine, University of Oulu, P.O. Box 5000, 90014 Oulu, Finland.

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http://dx.doi.org/10.1093/cvr/cvq267DOI Listing
January 2011

Metoprolol treatment lowers thrombospondin-4 expression in rats with myocardial infarction and left ventricular hypertrophy.

Basic Clin Pharmacol Toxicol 2010 Sep 28;107(3):709-17. Epub 2010 Mar 28.

Department of Pharmacology and Toxicology, Institute of Biomedicine, Biocenter Oulu, University of Oulu, Oulu, Finland.

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http://doi.wiley.com/10.1111/j.1742-7843.2010.00564.x
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http://dx.doi.org/10.1111/j.1742-7843.2010.00564.xDOI Listing
September 2010

GATA-4 is an angiogenic survival factor of the infarcted heart.

Circ Heart Fail 2010 May 3;3(3):440-50. Epub 2010 Mar 3.

Department of Pharmacology and Toxicology, Institute of Biomedicine, Biocenter Oulu, University of Oulu, Oulu, Finland.

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https://www.ahajournals.org/doi/10.1161/CIRCHEARTFAILURE.109
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http://dx.doi.org/10.1161/CIRCHEARTFAILURE.109.889642DOI Listing
May 2010

A novel p38 MAPK target dyxin is rapidly induced by mechanical load in the heart.

Blood Press 2010 Feb;19(1):54-63

Department of Pharmacology and Toxicology, Biocenter Oulu, University of Oulu, Oulu, Finland.

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http://dx.doi.org/10.3109/08037050903464519DOI Listing
February 2010

Apelin and its receptor APJ in human aortic valve stenosis.

J Heart Valve Dis 2009 Nov;18(6):644-52

Department of Pharmacology and Toxicology, University of Oulu, Biocenter Oulu, Finland.

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November 2009

Upregulation of cardiac matrix Gla protein expression in response to hypertrophic stimuli.

Blood Press 2009 ;18(5):286-93

Institute of Biomedicine, Department of Pharmacology and Toxicology, Biocenter Oulu, University of Oulu, Oulu, Finland.

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http://dx.doi.org/10.3109/08037050903244643DOI Listing
January 2010

Stress-induced hypertension and increased sympathetic activity in mice overexpressing neuropeptide Y in noradrenergic neurons.

Neuroendocrinology 2009 20;89(3):351-60. Epub 2008 Dec 20.

Department of Pharmacology, Drug Development and Therapeutics, University of Turku, Turku, Finland.

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http://dx.doi.org/10.1159/000188602DOI Listing
July 2009

Increase in tissue endothelin-1 and ETA receptor levels in human aortic valve stenosis.

Eur Heart J 2009 Jan 13;30(2):242-9. Epub 2008 Nov 13.

Department of Pharmacology and Toxicology, Institute of Biomedicine, University of Oulu, Biocenter Oulu, PO Box 5000, Aapistie 5, 90014 Oulu, Finland.

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http://eurheartj.oxfordjournals.org/content/ehj/30/2/242.ful
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http://eurheartj.oxfordjournals.org/cgi/doi/10.1093/eurheart
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http://dx.doi.org/10.1093/eurheartj/ehn482DOI Listing
January 2009

Functionally opposing roles of extracellular signal-regulated kinase 1/2 and p38 mitogen-activated protein kinase in the regulation of cardiac contractility.

Circulation 2008 Oct 29;118(16):1651-8. Epub 2008 Sep 29.

Institute of Biomedicine, Department of Pharmacology and Toxicology, Faculty of Medicine, University of Oulu, PO Box 5000, 90014 University of Oulu, Finland.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.107.758623DOI Listing
October 2008

Paricalcitol treatment and arterial tone in experimental renal insufficiency.

Nephron Exp Nephrol 2008 25;109(3):e84-93. Epub 2008 Jul 25.

Medical School, University of Tampere, Tampere, Finland.

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http://dx.doi.org/10.1159/000145464DOI Listing
November 2008

Adaptive or maladaptive response to adenoviral adrenomedullin gene transfer is context-dependent in the heart.

J Gene Med 2008 Aug;10(8):867-77

Institute of Biomedicine, Department of Pharmacology and Toxicology, Biocentre Oulu, University of Oulu, Oulu, Finland.

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http://doi.wiley.com/10.1002/jgm.1219
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http://dx.doi.org/10.1002/jgm.1219DOI Listing
August 2008

Thrombospondin-4 expression is rapidly upregulated by cardiac overload.

Biochem Biophys Res Commun 2008 Aug 9;373(2):186-91. Epub 2008 Jun 9.

Department of Pharmacology and Toxicology, Institute of Biomedicine, P.O. Box 5000, Biocenter Oulu, University of Oulu, Oulu, FIN-90014, Finland.

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http://dx.doi.org/10.1016/j.bbrc.2008.05.164DOI Listing
August 2008

Distinct downregulation of C-type natriuretic peptide system in human aortic valve stenosis.

Circulation 2007 Sep 20;116(11):1283-9. Epub 2007 Aug 20.

Department of Pharmacology and Toxicology, University of Oulu, PO Box 5000, 90014 Oulu, Finland.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.106.685743DOI Listing
September 2007

Cardiac BNP gene activation by angiotensin II in vivo.

Mol Cell Endocrinol 2007 Jul 16;273(1-2):59-67. Epub 2007 May 16.

Department of Physiology, Biocenter Oulu, University of Oulu, Oulu FIN-90014, Finland.

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http://dx.doi.org/10.1016/j.mce.2007.05.003DOI Listing
July 2007

Early left ventricular gene expression profile in response to increase in blood pressure.

Blood Press 2006 ;15(6):375-83

Department of Pharmacology and Toxicology, Biocenter Oulu, University of Oulu, Finland.

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http://dx.doi.org/10.1080/08037050601037851DOI Listing
June 2007

Involvement of endogenous ouabain-like compound in the cardiac hypertrophic process in vivo.

Life Sci 2007 Mar 12;80(14):1303-10. Epub 2007 Jan 12.

1st Department of Medicine, Semmelweis University, Budapest H-1083, Hungary; Szentágothai János Knowledge Center, Semmelweis University, Budapest H-1085, Hungary.

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http://dx.doi.org/10.1016/j.lfs.2006.12.026DOI Listing
March 2007

Endothelin-1 and angiotensin II contribute to BNP but not c-fos gene expression response to elevated load in isolated mice hearts.

Biochim Biophys Acta 2007 Mar 16;1772(3):338-44. Epub 2006 Nov 16.

Department of Pharmacology and Toxicology, Faculty of Medicine, Biocenter Oulu, University of Oulu PO Box 5000, FIN-90014 University of Oulu, Finland.

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http://dx.doi.org/10.1016/j.bbadis.2006.11.004DOI Listing
March 2007

Identification of cell cycle regulatory and inflammatory genes as predominant targets of p38 mitogen-activated protein kinase in the heart.

Circ Res 2006 Sep 27;99(5):485-93. Epub 2006 Jul 27.

Department of Pharmacology and Toxicology, Biocenter Oulu, Finland.

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http://dx.doi.org/10.1161/01.RES.0000238387.85144.92DOI Listing
September 2006

High-calcium vs high-phosphate intake and small artery tone in advanced experimental renal insufficiency.

Nephrol Dial Transplant 2006 Oct 12;21(10):2754-61. Epub 2006 Jul 12.

Medical School, Department of Internal Medicine, FIN-33014, University of Tampere, Finland.

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http://dx.doi.org/10.1093/ndt/gfl270DOI Listing
October 2006

Plasma N-terminal fragments of natriuretic propeptides predict the risk of cardiovascular events and mortality in middle-aged men.

Eur Heart J 2006 May 18;27(10):1230-7. Epub 2006 Apr 18.

Research Institute of Public Health, University of Kuopio, P.O.Box 1627, 70211 Kuopio, Finland.

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http://dx.doi.org/10.1093/eurheartj/ehi878DOI Listing
May 2006

Synergistic activation of salmon cardiac function by endothelin and beta-adrenergic stimulation.

Am J Physiol Heart Circ Physiol 2006 Sep 24;291(3):H1360-70. Epub 2006 Mar 24.

Department of Physiology, POB 5000, FIN-90014, University of Oulu, Oulu, Finland.

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http://dx.doi.org/10.1152/ajpheart.01326.2005DOI Listing
September 2006

Inverse regulation of preproendothelin-1 and endothelin-converting enzyme-1beta genes in cardiac cells by mechanical load.

Am J Physiol Regul Integr Comp Physiol 2006 Jun 12;290(6):R1639-45. Epub 2006 Jan 12.

Department of Pharmacology and Toxicology, Biocenter Oulu, University of Oulu, Finland.

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http://www.physiology.org/doi/10.1152/ajpregu.00559.2005
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http://dx.doi.org/10.1152/ajpregu.00559.2005DOI Listing
June 2006

Adrenomedullin gene transfer induces neointimal apoptosis and inhibits neointimal hyperplasia in injured rat artery.

J Gene Med 2006 Apr;8(4):452-8

Department of Pharmacology and Toxicology, University of Oulu, Biocenter Oulu, Oulu, Finland.

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http://doi.wiley.com/10.1002/jgm.865
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http://dx.doi.org/10.1002/jgm.865DOI Listing
April 2006

BNP as a biomarker in heart disease.

Adv Clin Chem 2005 ;40:1-36

Department of Physiology, Medical Faculty, Biocenter Oulu, FIN-90014 University of Oulu, Finland.

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January 2006