Heikki Järvinen

Heikki Järvinen

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Heikki Järvinen

Heikki Järvinen

Publications by authors named "Heikki Järvinen"

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Subtotal Colectomy for Colon Cancer Reduces the Need for Subsequent Surgery in Lynch Syndrome.

Dis Colon Rectum 2017 Aug;60(8):792-799

1 Department of Gastrointestinal Surgery, Helsinki University Hospital, University of Helsinki, Helsinki, Finland 2 Research Programs Unit, Genome-Scale Biology, University of Helsinki, Helsinki, Finland 3 Department of Education and Science, Central Finland Health Care District, Jyväskylä Finland and University of Eastern Finland, Finland.

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http://dx.doi.org/10.1097/DCR.0000000000000802DOI Listing
August 2017

Expression of CEA, CA19-9, CA125, and EpCAM in pseudomyxoma peritonei.

Hum Pathol 2016 08 30;54:47-54. Epub 2016 Mar 30.

Pathology, Research Programs Unit, University of Helsinki and Helsinki University Hospital, 00014, Helsinki, Finland; Pathology, Research Programs Unit and HUSLAB, University of Helsinki and Helsinki University Hospital, 00029, Helsinki, Finland. Electronic address:

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http://dx.doi.org/10.1016/j.humpath.2016.02.022DOI Listing
August 2016

CTCF/cohesin-binding sites are frequently mutated in cancer.

Nat Genet 2015 Jul 8;47(7):818-21. Epub 2015 Jun 8.

1] Genome-Scale Biology Research Program, Research Programs Unit, University of Helsinki, Helsinki, Finland. [2] Department of Medical and Clinical Genetics, Medicum, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1038/ng.3335DOI Listing
July 2015

Human population dynamics in Europe over the Last Glacial Maximum.

Proc Natl Acad Sci U S A 2015 Jul 22;112(27):8232-7. Epub 2015 Jun 22.

Department of Geosciences and Geography, University of Helsinki, FI-00014 Helsinki, Finland;

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http://dx.doi.org/10.1073/pnas.1503784112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4500234PMC
July 2015

Systematic search for rare variants in Finnish early-onset colorectal cancer patients.

Cancer Genet 2015 Jan-Feb;208(1-2):35-40. Epub 2014 Dec 31.

Department of Medical Genetics, Genome-Scale Biology Program, University of Helsinki, Biomedicum, Helsinki, Finland. Electronic address:

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http://dx.doi.org/10.1016/j.cancergen.2014.12.004DOI Listing
May 2015

Costs of colorectal cancer in different states of the disease.

Acta Oncol 2015 Apr 18;54(4):454-62. Epub 2014 Dec 18.

University of Helsinki, Department of Public Health , Helsinki , Finland.

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http://dx.doi.org/10.3109/0284186X.2014.985797DOI Listing
April 2015

Genomic profile of pseudomyxoma peritonei analyzed using next-generation sequencing and immunohistochemistry.

Int J Cancer 2015 Mar 13;136(5):E282-9. Epub 2014 Oct 13.

Genome-Scale Biology Research Program, Research Programs Unit, University of Helsinki, Helsinki, Finland.

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http://doi.wiley.com/10.1002/ijc.29245
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http://dx.doi.org/10.1002/ijc.29245DOI Listing
March 2015

Reply: To PMID 24941021.

Gastroenterology 2015 Jan 22;148(1):259. Epub 2014 Nov 22.

Department of Medical Genetics, Haartman Institute, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1053/j.gastro.2014.11.028DOI Listing
January 2015

Endoscopic papillectomy, single-centre experience.

Surg Endosc 2014 Nov 14;28(11):3234-9. Epub 2014 Jun 14.

Department of Gastrointestinal and General Surgery, Helsinki University Central Hospital, P.O. Box 340, 00029 HUS, Helsinki, Finland.

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http://dx.doi.org/10.1007/s00464-014-3596-5DOI Listing
November 2014

Promoter-specific alterations of APC are a rare cause for mutation-negative familial adenomatous polyposis.

Genes Chromosomes Cancer 2014 Oct 20;53(10):857-64. Epub 2014 Jun 20.

Department of Medical Genetics, Haartman Institute, University of Helsinki, Helsinki, Finland; Laboratorio de Citogenética y Mutagénesis, Instituto Multidisciplinario de Biología Celular (IMBICE-CONICET-CICPBA), La Plata, Argentina.

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http://dx.doi.org/10.1002/gcc.22197DOI Listing
October 2014

Mutations in Exon 1 highlight the role of MED12 in uterine leiomyomas.

Hum Mutat 2014 Sep 21;35(9):1136-41. Epub 2014 Jul 21.

Department of Medical Genetics, Genome-Scale Biology Research Program, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1002/humu.22612DOI Listing
September 2014

Comparison of serial debulking and cytoreductive surgery with hyperthermic intraperitoneal chemotherapy in pseudomyxoma peritonei of appendiceal origin.

Int J Colorectal Dis 2014 Aug 26;29(8):999-1007. Epub 2014 Jun 26.

Department of Surgery, Meilahti Hospital, Helsinki University Central Hospital, Haartmaninkatu 4, FI-00029, Helsinki, Finland,

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http://link.springer.com/10.1007/s00384-014-1933-8
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http://dx.doi.org/10.1007/s00384-014-1933-8DOI Listing
August 2014

Psychosocial consequences of predictive genetic testing for Lynch syndrome and associations to surveillance behaviour in a 7-year follow-up study.

Fam Cancer 2013 Dec;12(4):639-46

Department of Medical Genetics, Haartman Institute Biomedicum, University of Helsinki, PO Box 63, FIN-00014, Helsinki, Finland,

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http://link.springer.com/10.1007/s10689-013-9628-9
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http://dx.doi.org/10.1007/s10689-013-9628-9DOI Listing
December 2013

Distinct molecular profiles in Lynch syndrome-associated and sporadic ovarian carcinomas.

Int J Cancer 2013 Dec 21;133(11):2596-608. Epub 2013 Jun 21.

Department of Medical Genetics, Haartman Institute, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1002/ijc.28287DOI Listing
December 2013

Exome sequencing in diagnostic evaluation of colorectal cancer predisposition in young patients.

Scand J Gastroenterol 2013 Jun 2;48(6):672-8. Epub 2013 Apr 2.

Department of Medical Genetics, Genome-Scale Biology Program, University of Helsinki, Biomedicum, P.O. Box 63, FIN-00014 University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.3109/00365521.2013.783102DOI Listing
June 2013

Segregation of a missense variant in enteric smooth muscle actin γ-2 with autosomal dominant familial visceral myopathy.

Gastroenterology 2012 Dec 6;143(6):1482-1491.e3. Epub 2012 Sep 6.

Department of Medical Genetics, Genome-Scale Biology Research Program, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1053/j.gastro.2012.08.045DOI Listing
December 2012

Uroepithelial and kidney carcinoma in Lynch syndrome.

Fam Cancer 2012 Sep;11(3):395-401

Department of Surgery, Jyväskylä Central Hospital, Jyväskylä, Finland.

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http://link.springer.com/10.1007/s10689-012-9526-6
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http://dx.doi.org/10.1007/s10689-012-9526-6DOI Listing
September 2012

Causes of death of mutation carriers in Finnish Lynch syndrome families.

Fam Cancer 2012 Sep;11(3):467-71

Department of Surgery, Jyväskylä Central Hospital, Jyväskylä, Finland.

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http://dx.doi.org/10.1007/s10689-012-9537-3DOI Listing
September 2012

Sharing genetic risk with next generation: mutation-positive parents' communication with their offspring in Lynch Syndrome.

Fam Cancer 2011 Mar;10(1):43-50

Department of Medical Genetics, Haartman Institute Biomedicum, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1007/s10689-010-9386-xDOI Listing
March 2011

Systematic search for enhancer elements and somatic allelic imbalance at seven low-penetrance colorectal cancer predisposition loci.

BMC Med Genet 2011 Feb 14;12:23. Epub 2011 Feb 14.

Department of Medical Genetics, Genome-Scale Biology Research Program, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1186/1471-2350-12-23DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3045878PMC
February 2011

Somatic mutations and germline sequence variants in patients with familial colorectal cancer.

Int J Cancer 2010 Dec;127(12):2974-80

Department of Medical Genetics, Genome-Scale Biology Research Program, Biomedicum Helsinki, University of Helsinki, Finland.

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http://dx.doi.org/10.1002/ijc.25529DOI Listing
December 2010

[Treatment of pseudomyxoma peritonei is developing].

Duodecim 2010 ;126(14):1693-9

HYKS:n kirurgian klinikka, PL 340, 00029 HUS.

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September 2010

Low-penetrance susceptibility variants in familial colorectal cancer.

Cancer Epidemiol Biomarkers Prev 2010 Jun 25;19(6):1478-83. Epub 2010 May 25.

Department of Medical Genetics, Genome-Scale Biology Research Program, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1158/1055-9965.EPI-09-1320DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2883738PMC
June 2010

Primary sclerosing cholangitis: outcome of patients undergoing restorative proctocolecetomy for ulcerative colitis.

Int J Colorectal Dis 2009 Oct 28;24(10):1169-74. Epub 2009 Jul 28.

Department of Surgery, Helsinki University Central Hospital, PL 340, HUS, 00029, Helsinki, Finland.

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http://dx.doi.org/10.1007/s00384-009-0773-4DOI Listing
October 2009

Ten years after mutation testing for Lynch syndrome: cancer incidence and outcome in mutation-positive and mutation-negative family members.

J Clin Oncol 2009 Oct 31;27(28):4793-7. Epub 2009 Aug 31.

Department of Surgery, University of Helsinki, FI-00029 HUS, Helsinki, Finland.

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http://dx.doi.org/10.1200/JCO.2009.23.7784DOI Listing
October 2009

[Rectal cancer].

Duodecim 2009 ;125(8):857-65

HYKS:n kirurgian klinikka, PL 340, 00029 HUS.

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August 2009

Genotype predicting phenotype in familial adenomatous polyposis: a practical application to the choice of surgery.

Dis Colon Rectum 2009 Jul;52(7):1259-63

The Netherlands Foundation for the Detection of Hereditary Tumours, Leiden, The Netherlands. m.nieuwenhuis.stoet.nl

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http://dx.doi.org/10.1007/DCR.0b013e3181a0d33bDOI Listing
July 2009

[Colonic carcinoma].

Duodecim 2009 ;125(6):619-28

HYKS:n syöpätautien klinikka, HUS.

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May 2009

Colectomy and ileorectal anastomosis is still an option for selected patients with familial adenomatous polyposis.

Dis Colon Rectum 2008 Sep 4;51(9):1318-23. Epub 2008 Jun 4.

The Danish Polyposis Register, Hvidovre University Hospital, Copenhagen, Denmark.

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http://dx.doi.org/10.1007/s10350-008-9307-3DOI Listing
September 2008

Prevalence of primary sclerosing cholangitis in ulcerative colitis patients undergoing proctocolectomy and ileal pouch-anal anastomosis.

Inflamm Bowel Dis 2008 Jun;14(6):775-9

Department of Surgery, Helsinki University Central Hospital, Finland.

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http://dx.doi.org/10.1002/ibd.20384DOI Listing
June 2008

[Not Available].

Duodecim 2006 ;122(18):2189-91

HYKS: n kirurgian klinikka.

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April 2008

Unregulated smooth-muscle myosin in human intestinal neoplasia.

Proc Natl Acad Sci U S A 2008 Apr 7;105(14):5513-8. Epub 2008 Apr 7.

Department of Medical Genetics and Division of Pathology, HUSLAB and Haartman Institute, Helsinki University Central Hospital and Genome Scale Biology Program, Biomedicum Helsinki, University of Helsinki, 00014, Helsinki, Finland.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0801213105
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http://dx.doi.org/10.1073/pnas.0801213105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2291082PMC
April 2008

Allelic imbalance at rs6983267 suggests selection of the risk allele in somatic colorectal tumor evolution.

Cancer Res 2008 Jan;68(1):14-7

Department of Medical Genetics, Genome-Scale Biology Research Program, Biomedicum Helsinki, University of Helsinki, P.O. Box 63, FIN-00014 Helsinki, Finland.

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http://dx.doi.org/10.1158/0008-5472.CAN-07-5766DOI Listing
January 2008

Development of colorectal tumors in colonoscopic surveillance in Lynch syndrome.

Gastroenterology 2007 Oct 14;133(4):1093-8. Epub 2007 Aug 14.

Department of Surgery, Jyväskylä Central Hospital, Jyväskylä, Finland.

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http://dx.doi.org/10.1053/j.gastro.2007.08.019DOI Listing
October 2007

Utility of computed tomographic colonography in surveillance for hereditary nonpolyposis colorectal cancer syndrome.

Fam Cancer 2007 ;6(1):135-40

Department of Surgery, Helsinki University Central Hospital, Haartmaninkatu 4, PL 340, 00029 HUS Helsinki, Finland.

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http://dx.doi.org/10.1007/s10689-007-9116-1DOI Listing
September 2007

No evidence for association of NOD2 R702W and G908R with colorectal cancer.

Int J Cancer 2007 Jul;121(1):76-9

Department of Medical Genetics, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1002/ijc.22651DOI Listing
July 2007

Background mutation frequency in microsatellite-unstable colorectal cancer.

Cancer Res 2007 Jun;67(12):5691-8

Department of Medical Genetics, Biomedicum Helsinki, University of Helsinki, Finland.

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http://dx.doi.org/10.1158/0008-5472.CAN-06-4314DOI Listing
June 2007

Surveillance for endometrial cancer in hereditary nonpolyposis colorectal cancer syndrome.

Int J Cancer 2007 Feb;120(4):821-4

Department of Surgery, Helsinki University Central Hospital, Helsinki, Finland.

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http://dx.doi.org/10.1002/ijc.22446DOI Listing
February 2007

Explaining the familial colorectal cancer risk associated with mismatch repair (MMR)-deficient and MMR-stable tumors.

Clin Cancer Res 2007 Jan;13(1):356-61

Department of Medical Genetics, Biomedicum Helsinki, University of Helsinki, Finland.

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http://dx.doi.org/10.1158/1078-0432.CCR-06-1256DOI Listing
January 2007

EPHB2 germline variants in patients with colorectal cancer or hyperplastic polyposis.

BMC Cancer 2006 Jun 1;6:145. Epub 2006 Jun 1.

Department of Medical Genetics, Molecular and Cancer Biology Research Program, P,O, BOX 63, 00014 University of Helsinki, Finland.

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http://dx.doi.org/10.1186/1471-2407-6-145DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1513590PMC
June 2006

Preferential amplification of AURKA 91A (Ile31) in familial colorectal cancers.

Int J Cancer 2006 Jan;118(2):505-8

Department of Medical Genetics, Biomedicum Helsinki, University of Helsinki, Finland.

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http://dx.doi.org/10.1002/ijc.21344DOI Listing
January 2006

Surveillance in Lynch syndrome.

Fam Cancer 2005 ;4(3):267-71

Department of Surgery, Jyväskylä Central Hospital, 40620, Jyväskylä, Finland.

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http://dx.doi.org/10.1007/s10689-005-1475-xDOI Listing
December 2005

A novel functionally deficient MYH variant in individuals with colorectal adenomatous polyposis.

Hum Mutat 2005 Oct;26(4):393

Department of Medical Genetics, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1002/humu.9368DOI Listing
October 2005

Numbers of mutations to different types of colorectal cancer.

BMC Cancer 2005 Oct 3;5:126. Epub 2005 Oct 3.

Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089, USA.

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http://dx.doi.org/10.1186/1471-2407-5-126DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1266026PMC
October 2005

p53 codon 72 and MDM2 SNP309 polymorphisms and age of colorectal cancer onset in Lynch syndrome.

Clin Cancer Res 2005 Oct;11(19 Pt 1):6840-4

Human Cancer Genetics Program, Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio 43210, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-05-1139DOI Listing
October 2005

SMAD4 levels and response to 5-fluorouracil in colorectal cancer.

Clin Cancer Res 2005 Sep;11(17):6311-6

Department of Medical Genetics, Biomedicum Helsinki, Haartman Institute, University of Helsinki, Finland.

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http://dx.doi.org/10.1158/1078-0432.CCR-05-0244DOI Listing
September 2005

Adenomatous polyposis families that screen APC mutation-negative by conventional methods are genetically heterogeneous.

J Clin Oncol 2005 Aug;23(24):5651-9

Department of Medical Genetics, Institute of Dentistry, Biomedicum Helsinki, PO Box 63 (Haartmaninkatu 8), FIN-00014 University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1200/JCO.2005.14.712DOI Listing
August 2005

[From animal models to human trials of Peutz-Jeghers syndrome].

Duodecim 2004 ;120(19):2353-4

Molekyyli-ja syöpäbiologian tutkimusohjelma ja Biolääketieteen laitos, Helsingin yliopisto.

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May 2005

SMAD4 as a prognostic marker in colorectal cancer.

Clin Cancer Res 2005 Apr;11(7):2606-11

Centre d'Investigacions en Bioquimica i Biologia Molecular, Hospital Universitari Vall d'Hebron, Barcelona, Spain.

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http://dx.doi.org/10.1158/1078-0432.CCR-04-1458DOI Listing
April 2005

CEA, CA 242, CA 19-9, CA 72-4 and hCGbeta in the diagnosis of recurrent colorectal cancer.

Tumour Biol 2004 Sep-Dec;25(5-6):228-34

Department of Surgery, Helsinki University Central Hospital, FI-00029 HUS, Helsinki, Finland.

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http://dx.doi.org/10.1159/000081385DOI Listing
January 2005

Suppression of Peutz-Jeghers polyposis by inhibition of cyclooxygenase-2.

Gastroenterology 2004 Oct;127(4):1030-7

Molecular Cancer Biology Research Program, Biomedicum Helsinki, Finland.

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http://dx.doi.org/10.1053/j.gastro.2004.07.059DOI Listing
October 2004

NOD2 3020insC alone is not sufficient for colorectal cancer predisposition.

Cancer Res 2004 Oct;64(20):7245-7

Department of Medical Genetics, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1158/0008-5472.CAN-04-2364DOI Listing
October 2004

Ileal pouch-anal anastomosis, conventional ileostomy and ileorectal anastomosis modify cholesterol metabolism.

Dig Dis Sci 2004 Sep;49(9):1444-53

Gastroenterology, Department of Medicine, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1023/b:ddas.0000042244.56689.72DOI Listing
September 2004

Estimating the probability of cancer with several tumor markers in patients with colorectal disease.

Oncology 2004 ;66(4):296-302

Department of Surgery, Helsinki University Central Hospital, Helsinki, Finland.

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http://dx.doi.org/10.1159/000078330DOI Listing
July 2004

Mutations in AXIN2 cause familial tooth agenesis and predispose to colorectal cancer.

Am J Hum Genet 2004 May 23;74(5):1043-50. Epub 2004 Mar 23.

Institute of Dentistry, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1086/386293DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1181967PMC
May 2004

Colorectal pretumor progression before and after loss of DNA mismatch repair.

Am J Pathol 2004 Apr;164(4):1447-53

Department of Biological Sciences, Program in Molecular and Computational Biology, University of Southern California, Los Angeles, California 90033, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1615342PMC
http://dx.doi.org/10.1016/S0002-9440(10)63231-2DOI Listing
April 2004

The complex genotype-phenotype relationship in familial adenomatous polyposis.

Eur J Gastroenterol Hepatol 2004 Jan;16(1):5-8

Department of Gastroenterological Surgery, Helsinki University Central Hospital, Helsinki, Finland.

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http://dx.doi.org/10.1097/00042737-200401000-00002DOI Listing
January 2004