Heike Biebermann

Heike Biebermann

UNVERIFIED PROFILE

Are you Heike Biebermann?   Register this Author

Register author
Heike Biebermann

Heike Biebermann

Publications by authors named "Heike Biebermann"

Are you Heike Biebermann?   Register this Author

100Publications

2213Reads

24Profile Views

Differential Signaling Profiles of MC4R Mutations with Three Different Ligands.

Int J Mol Sci 2020 Feb 12;21(4). Epub 2020 Feb 12.

Institute of Experimental Pediatric Endocrinology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, D-10117 Berlin, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/ijms21041224DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072973PMC
February 2020

3-Iodothyronamine Induces Diverse Signaling Effects at Different Aminergic and Non-Aminergic G-Protein Coupled Receptors.

Exp Clin Endocrinol Diabetes 2019 Nov 7. Epub 2019 Nov 7.

Institute of Medical Physics and Biophysics, Group Protein X-ray Crystallography and Signal Transduction, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/a-1022-1554DOI Listing
November 2019

The Pathogenic TSH β-subunit Variant C105Vfs114X Causes a Modified Signaling Profile at TSHR.

Int J Mol Sci 2019 Nov 7;20(22). Epub 2019 Nov 7.

Institute of Experimental Pediatric Endocrinology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, 13353 Berlin, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/ijms20225564DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6888357PMC
November 2019

Signal Transduction and Pathogenic Modifications at the Melanocortin-4 Receptor: A Structural Perspective.

Front Endocrinol (Lausanne) 2019 31;10:515. Epub 2019 Jul 31.

Group Protein X-ray Crystallography and Signal Transduction, Institute of Medical Physics and Biophysics, Berlin Institute of Health, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fendo.2019.00515DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6685040PMC
July 2019

Evaluation of a rare glucose-dependent insulinotropic polypeptide receptor variant in a patient with diabetes.

Diabetes Obes Metab 2019 05 19;21(5):1168-1176. Epub 2019 Feb 19.

Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany; Institute of Experimental Pediatric Endocrinology, Berlin, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/dom.13634DOI Listing
May 2019

A New Multisystem Disorder Caused by the Gαs Mutation p.F376V.

J Clin Endocrinol Metab 2019 04;104(4):1079-1089

Department for Pediatric Endocrinology and Diabetology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1210/jc.2018-01250DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380466PMC
April 2019

3-Iodothyronamine-A Thyroid Hormone Metabolite With Distinct Target Profiles and Mode of Action.

Endocr Rev 2019 04;40(2):602-630

Institut für Experimentelle Pädiatrische Endokrinologie, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1210/er.2018-00182DOI Listing
April 2019

Melanocortin-4 Receptor Signalling: Importance for Weight Regulation and Obesity Treatment.

Trends Mol Med 2019 02 11;25(2):136-148. Epub 2019 Jan 11.

Institute for Experimental Pediatric Endocrinology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Augustenburger Platz 1, 13353 Berlin, Germany.

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S14714914183022
Publisher Site
http://dx.doi.org/10.1016/j.molmed.2018.12.002DOI Listing
February 2019

An incretin-based tri-agonist promotes superior insulin secretion from murine pancreatic islets via PLC activation.

Cell Signal 2018 11 25;51:13-22. Epub 2018 Jul 25.

Institute of Experimental Pediatric Endocrinology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cellsig.2018.07.006DOI Listing
November 2018

3-Iodothyronamine Activates a Set of Membrane Proteins in Murine Hypothalamic Cell Lines.

Front Endocrinol (Lausanne) 2018 11;9:523. Epub 2018 Sep 11.

Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.

View Article

Download full-text PDF

Source
https://www.frontiersin.org/article/10.3389/fendo.2018.00523
Publisher Site
http://dx.doi.org/10.3389/fendo.2018.00523DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161562PMC
September 2018

Relevance of polymorphisms in MC4R and BDNF in short normal stature.

BMC Pediatr 2018 08 22;18(1):278. Epub 2018 Aug 22.

Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12887-018-1245-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6106737PMC
August 2018

Evidence of G-protein-coupled receptor and substrate transporter heteromerization at a single molecule level.

Cell Mol Life Sci 2018 06 30;75(12):2227-2239. Epub 2017 Dec 30.

Institut für Experimentelle Pädiatrische Endokrinologie, Charité - Universitätsmedizin Berlin, 13353, Berlin, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00018-017-2728-1DOI Listing
June 2018

MC4R agonism promotes durable weight loss in patients with leptin receptor deficiency.

Nat Med 2018 05 7;24(5):551-555. Epub 2018 May 7.

Institute for Experimental Pediatric Endocrinology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Berlin, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41591-018-0015-9DOI Listing
May 2018

The Trace Amine-Associated Receptor 1 Agonist 3-Iodothyronamine Induces Biased Signaling at the Serotonin 1b Receptor.

Front Pharmacol 2018 12;9:222. Epub 2018 Mar 12.

Institute of Experimental Pediatric Endocrinology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fphar.2018.00222DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5857711PMC
March 2018

Investigation of Naturally Occurring Single-Nucleotide Variants in Human TAAR1.

Front Pharmacol 2017 24;8:807. Epub 2017 Nov 24.

Institute of Experimental Pediatric Endocrinology, Charité - Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universitt zu Berlin, Berlin, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fphar.2017.00807DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5705543PMC
November 2017

3-Iodothyronamine, a Novel Endogenous Modulator of Transient Receptor Potential Melastatin 8?

Front Endocrinol (Lausanne) 2017 16;8:198. Epub 2017 Aug 16.

Institute for Experimental Pediatric Endocrinology, Charité University of Medicine Berlin, Berlin, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fendo.2017.00198DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5561014PMC
August 2017

The long N-terminus of the human monocarboxylate transporter 8 is a target of ubiquitin-dependent proteasomal degradation which regulates protein expression and oligomerization capacity.

Mol Cell Endocrinol 2016 10 21;434:278-87. Epub 2016 May 21.

University of Duisburg-Essen, Department of Endocrinology and Metabolism and Division of Laboratory Research, Hufelandstraße 55, 45147 Essen, Germany. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.mce.2016.05.017DOI Listing
October 2016

Minireview: Insights Into the Structural and Molecular Consequences of the TSH-β Mutation C105Vfs114X.

Mol Endocrinol 2016 Sep 7;30(9):954-64. Epub 2016 Jul 7.

Institute of Experimental Pediatric Endocrinology (G.K., L.K., H.B.), Charité-Universitätsmedizin, Berlin, 13353 Germany; Institute of Experimental Endocrinology (J.K., L.S.), Charité-Universitätsmedizin Berlin, 13353 Germany; Trophogen, Inc (M.S.), Rockville, Maryland 20850; and Department of Pediatric Endocrinology and Diabetes (A.G.-K.), Charité-Universitätsmedizin, Berlin, 13353 Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1210/me.2016-1065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5414609PMC
September 2016

Decreased melanocortin-4 receptor function conferred by an infrequent variant at the human melanocortin receptor accessory protein 2 gene.

Obesity (Silver Spring) 2016 09 30;24(9):1976-82. Epub 2016 Jul 30.

Department of Child and Adolescent Psychiatry, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/oby.21576DOI Listing
September 2016

Ring Finger Protein 11 Inhibits Melanocortin 3 and 4 Receptor Signaling.

Front Endocrinol (Lausanne) 2016 8;7:109. Epub 2016 Aug 8.

Institut für Experimentelle Pädiatrische Endokrinologie, Charité-Universitätsmedizin Berlin , Berlin , Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fendo.2016.00109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4976663PMC
August 2016

Oligomerization of GPCRs involved in endocrine regulation.

J Mol Endocrinol 2016 07 5;57(1):R59-80. Epub 2016 May 5.

Institute of Experimental Pediatric Endocrinology (IEPE)Charité-Universitätsmedizin, Berlin, Germany

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1530/JME-16-0049DOI Listing
July 2016

A novel hemizygous mutation of MAMLD1 in a patient with 46,XY complete gonadal dysgenesis.

Sex Dev 2015 3;9(2):80-5. Epub 2015 Feb 3.

Institute for Experimental Paediatric Endocrinology, Charité, Humboldt University Berlin, Berlin, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000371603DOI Listing
February 2016

Understanding the Healthy Thyroid State in 2015.

Eur Thyroid J 2015 Sep 27;4(Suppl 1):1-8. Epub 2015 May 27.

Institut für Experimentelle Pädiatrische Endokrinologie, Charité-Universitätsmedizin Berlin, Berlin, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000431318DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4640297PMC
September 2015

Evolutionary Conservation of 3-Iodothyronamine as an Agonist at the Trace Amine-Associated Receptor 1.

Eur Thyroid J 2015 Sep 29;4(Suppl 1):9-20. Epub 2015 May 29.

Institute of Biochemistry, Faculty of Medicine, University of Leipzig, Leipzig, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000430839DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4640299PMC
September 2015

Two Novel Mutations in the Serpina7 Gene Are Associated with Complete Deficiency of Thyroxine-Binding Globulin.

Eur Thyroid J 2015 Sep 30;4(Suppl 1):108-12. Epub 2015 May 30.

Department of Endocrinology and Metabolism, University of Duisburg-Essen, Essen, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000381093DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4640287PMC
September 2015

Loss-of-Function Variants in a Hungarian Cohort Reveal Structural Insights on TSH Receptor Maturation and Signaling.

J Clin Endocrinol Metab 2015 Jul 15;100(7):E1039-45. Epub 2015 May 15.

Department of Laboratory Medicine (A.L., O.R., A.M., G.L.K.), University of Pécs, 7624 Pécs, Hungary; Department of Clinical Sciences and Community Health (E.S.G., L.P.), University of Milan, 20122 Milan, Italy; Department of Pediatrics and Pediatric Health Care Center (B.G.), University of Szeged, 6720 Szeged, Hungary; Institute of Experimental Pediatric Endocrinology (G.K., H.B.), Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany; First Department of Internal Medicine (B.R., E.M.), University of Pécs, 7624 Pécs, Hungary; Division of Endocrine and Metabolic Diseases and Laboratory of Endocrine and Metabolic Research (G.G., L.P.), Ospedale San Luca, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Istituto Auxologico Italiano, 20149 Milan, Italy; Szentágothai Research Centre (G.L.K.), University of Pécs, 7624 Pécs, Hungary; HAS-SE "Lendület" Hereditary Endocrine Tumors Research Group (A.P.), 1085 Budapest, Hungary; and Departments of Pediatrics (E.F.) and Internal Medicine (E.V.N.), Faculty of Medicine, University of Debrecen, 4032 Debrecen Hungary.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1210/jc.2014-4511DOI Listing
July 2015

3-iodothyronamine differentially modulates α-2A-adrenergic receptor-mediated signaling.

J Mol Endocrinol 2015 Jun 15;54(3):205-16. Epub 2015 Apr 15.

Institut für Experimentelle Pädiatrische EndokrinologieCharité-Universitätsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, GermanyDepartment of Cell and Molecular BiologyKarolinska Institutet, Stockholm, SwedenInstitut für BiochemieMolekulare Biochemie, Medizinische Fakultät, University of Leipzig, Leipzig, GermanyInstitut für Experimentelle EndokrinologieCharité-Universitätsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1530/JME-15-0003DOI Listing
June 2015

Treatment of congenital thyroid dysfunction: Achievements and challenges.

Best Pract Res Clin Endocrinol Metab 2015 Jun 26;29(3):399-413. Epub 2015 Apr 26.

Institute for Experimental Paediatric Endocrinology, Charite, University-Medicine-Berlin, Augustenburgerplatz 1, D-13353 Berlin, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.beem.2015.04.004DOI Listing
June 2015

Modulation of monocarboxylate transporter 8 oligomerization by specific pathogenic mutations.

J Mol Endocrinol 2015 Feb;54(1):39-50

Institut für Experimentelle Pädiatrische EndokrinologieCharité-Universitätsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, GermanyLeibniz-Institut für Molekulare PharmakologieBerlin, GermanyUniversitätsklinikum EssenKlinik für Endokrinologie und Stoffwechselerkrankungen, Essen, GermanyJacobs University BremenBremen, Germany

View Article

Download full-text PDF

Source
https://jme.bioscientifica.com/view/journals/jme/54/1/39.xml
Publisher Site
http://dx.doi.org/10.1530/JME-14-0272DOI Listing
February 2015

Constitutive activities in the thyrotropin receptor: regulation and significance.

Adv Pharmacol 2014 ;70:81-119

Institute of Experimental Pediatric Endocrinology, Charité-Universitätsmedizin Berlin, Berlin, Germany.

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/B97801241719780
Publisher Site
http://dx.doi.org/10.1016/B978-0-12-417197-8.00003-1DOI Listing
January 2015

The extracellular N-terminal domain of G-protein coupled receptor 83 regulates signaling properties and is an intramolecular inverse agonist.

BMC Res Notes 2014 Dec 16;7:913. Epub 2014 Dec 16.

Institute of Experimental Pediatric Endocrinology, Charité-Universitätsmedizin Berlin, Augustenburger Platz 1, Ostring 3, 13353 Berlin, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/1756-0500-7-913DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4300838PMC
December 2014

Analysis of human TAAR8 and murine Taar8b mediated signaling pathways and expression profile.

Int J Mol Sci 2014 Nov 10;15(11):20638-55. Epub 2014 Nov 10.

Institut für Experimentelle Pädiatrische Endokrinologie, Charité-Universitätsmedizin, Campus Virchow-Klinikum, Augustenburger Platz 1, 13353 Berlin, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/ijms151120638DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4264187PMC
November 2014

TSH induces metallothionein 1 in thyrocytes via Gq/11- and PKC-dependent signaling.

J Mol Endocrinol 2013 4;51(1):79-90. Epub 2013 Jun 4.

Medical Department III, University Hospital Aachen, D-52074 Aachen, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1530/JME-12-0200DOI Listing
January 2014

Inhibition of melanocortin-4 receptor dimerization by substitutions in intracellular loop 2.

J Mol Endocrinol 2013 29;51(1):109-18. Epub 2013 Jun 29.

Institute of Experimental Pediatric Endocrinology, Charité-Universitätsmedizin Berlin, Humboldt-Universität zu Berlin, Augustenburger Platz 1, 13353 Berlin, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1530/JME-13-0061DOI Listing
January 2014

Identification of PENDRIN (SLC26A4) mutations in patients with congenital hypothyroidism and "apparent" thyroid dysgenesis.

J Clin Endocrinol Metab 2014 Jan 20;99(1):E169-76. Epub 2013 Dec 20.

Institute of Experimental Pediatric Endocrinology (P.K., H.B., A.G., H.K.), Charité Universitätsmedizin Berlin, 13353 Berlin, Germany; Department of Pediatric Endocrinology and Diabetes (S.T., T.G., S.A., A.B.), Marmara University Hospital, 34722 Istanbul, Turkey; and Max-Delbrück Center for Molecular Medicine (S.F., W.C.), 13092 Berlin-Buch, Germany.

View Article

Download full-text PDF

Source
https://academic.oup.com/jcem/article-lookup/doi/10.1210/jc.
Publisher Site
http://dx.doi.org/10.1210/jc.2013-2619DOI Listing
January 2014

Novel insights on thyroid-stimulating hormone receptor signal transduction.

Endocr Rev 2013 Oct 3;34(5):691-724. Epub 2013 May 3.

Institute of Experimental Pediatric Endocrinology, Charité-Universitätsmedizin Berlin, Ostring 3, Augustenburger Platz 1, 13353 Berlin, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1210/er.2012-1072DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3785642PMC
October 2013

MC4R dimerization in the paraventricular nucleus and GHSR/MC3R heterodimerization in the arcuate nucleus: is there relevance for body weight regulation?

Neuroendocrinology 2012 8;95(4):277-88. Epub 2012 Feb 8.

Institute of Experimental Pediatric Endocrinology, Charité Universitätsmedizin Berlin, Humboldt University, Berlin, Germany.

View Article

Download full-text PDF

Source
https://www.karger.com/Article/FullText/334903
Publisher Site
http://dx.doi.org/10.1159/000334903DOI Listing
October 2012

Identification of the translation start site of the human melanocortin 3 receptor.

Obes Facts 2012 2;5(1):45-51. Epub 2012 Mar 2.

Institute of Experimental Pediatric Endocrinology, Charité-Universitätsmedizin Berlin, Humboldt University, Augustenburger Platz 1, Berlin, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000336070DOI Listing
July 2012

Testosterone production during puberty in two 46,XY patients with disorders of sex development and novel NR5A1 (SF-1) mutations.

Eur J Endocrinol 2012 Jul 3;167(1):125-30. Epub 2012 Apr 3.

Department of Pediatric Endocrinology, University Children's Hospital, Charité, Humboldt University, Augustenburger Platz 1, 13353 Berlin, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1530/EJE-11-0944DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3381348PMC
July 2012

Rescue of melanocortin 4 receptor (MC4R) nonsense mutations by aminoglycoside-mediated read-through.

Obesity (Silver Spring) 2012 May 7;20(5):1074-81. Epub 2011 Jul 7.

Institute of Experimental Pediatric Endocrinology, Charité Universitätsmedizin Berlin, Berlin, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/oby.2011.202DOI Listing
May 2012

The neuroendocrine circuitry controlled by POMC, MSH, and AGRP.

Handb Exp Pharmacol 2012 (209):47-75

Institut für Experimentelle Pädiatrische Endokrinologie, Charité Universitätsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-3-642-24716-3_3DOI Listing
April 2012

New pathogenic thyrotropin receptor mutations decipher differentiated activity switching at a conserved helix 6 motif of family A GPCR.

J Clin Endocrinol Metab 2012 Feb 23;97(2):E228-32. Epub 2011 Nov 23.

Institute of Experimental Pediatric Endocrinology, Charité-Universitätsmedizin Berlin, Ostring 3, Augustenburger Platz 1, 13353 Berlin, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1210/jc.2011-2106DOI Listing
February 2012

Plasma bile acids are associated with energy expenditure and thyroid function in humans.

J Clin Endocrinol Metab 2012 Feb 7;97(2):535-42. Epub 2011 Dec 7.

Department of Gastroenterology, Hepatology, Endocrinology, and Nutrition, Klinikum Bremen Mitte, St. Juergen Strasse 1, D-28177 Bremen, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1210/jc.2011-2329DOI Listing
February 2012

What is hot in experimental thyroidology?

Authors:
Heike Biebermann

Thyroid Res 2011 Aug 3;4 Suppl 1:I1. Epub 2011 Aug 3.

Institute of Experimental Pediatric Endocrinology, Charité Universitätsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/1756-6614-4-S1-I1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3155106PMC
August 2011

Molecular description of non-autoimmune hyperthyroidism at a neonate caused by a new thyrotropin receptor germline mutation.

Thyroid Res 2011 Aug 3;4 Suppl 1:S8. Epub 2011 Aug 3.

Institute of Experimental Paediatric Endocrinology, Charité Universitätsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/1756-6614-4-S1-S8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3155114PMC
August 2011

Molecules important for thyroid hormone synthesis and action - known facts and future perspectives.

Thyroid Res 2011 Aug 3;4 Suppl 1:S9. Epub 2011 Aug 3.

Institute of Experimental Pediatric Endocrinology, Charité Universitätsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/1756-6614-4-S1-S9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3155115PMC
August 2011

Proinsulin and the proinsulin/insulin ratio in overweight and obese children and adolescents: relation to clinical parameters, insulin resistance, and impaired glucose regulation.

Pediatr Diabetes 2011 May 29;12(3 Pt 2):242-9. Epub 2011 Mar 29.

Department of Pediatric Endocrinology and Diabetology, Charité Universitätsmedizin Berlin, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1399-5448.2010.00734.xDOI Listing
May 2011

Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.

Authors:
Elizabeth K Speliotes Cristen J Willer Sonja I Berndt Keri L Monda Gudmar Thorleifsson Anne U Jackson Hana Lango Allen Cecilia M Lindgren Jian'an Luan Reedik Mägi Joshua C Randall Sailaja Vedantam Thomas W Winkler Lu Qi Tsegaselassie Workalemahu Iris M Heid Valgerdur Steinthorsdottir Heather M Stringham Michael N Weedon Eleanor Wheeler Andrew R Wood Teresa Ferreira Robert J Weyant Ayellet V Segrè Karol Estrada Liming Liang James Nemesh Ju-Hyun Park Stefan Gustafsson Tuomas O Kilpeläinen Jian Yang Nabila Bouatia-Naji Tõnu Esko Mary F Feitosa Zoltán Kutalik Massimo Mangino Soumya Raychaudhuri Andre Scherag Albert Vernon Smith Ryan Welch Jing Hua Zhao Katja K Aben Devin M Absher Najaf Amin Anna L Dixon Eva Fisher Nicole L Glazer Michael E Goddard Nancy L Heard-Costa Volker Hoesel Jouke-Jan Hottenga Asa Johansson Toby Johnson Shamika Ketkar Claudia Lamina Shengxu Li Miriam F Moffatt Richard H Myers Narisu Narisu John R B Perry Marjolein J Peters Michael Preuss Samuli Ripatti Fernando Rivadeneira Camilla Sandholt Laura J Scott Nicholas J Timpson Jonathan P Tyrer Sophie van Wingerden Richard M Watanabe Charles C White Fredrik Wiklund Christina Barlassina Daniel I Chasman Matthew N Cooper John-Olov Jansson Robert W Lawrence Niina Pellikka Inga Prokopenko Jianxin Shi Elisabeth Thiering Helene Alavere Maria T S Alibrandi Peter Almgren Alice M Arnold Thor Aspelund Larry D Atwood Beverley Balkau Anthony J Balmforth Amanda J Bennett Yoav Ben-Shlomo Richard N Bergman Sven Bergmann Heike Biebermann Alexandra I F Blakemore Tanja Boes Lori L Bonnycastle Stefan R Bornstein Morris J Brown Thomas A Buchanan Fabio Busonero Harry Campbell Francesco P Cappuccio Christine Cavalcanti-Proença Yii-Der Ida Chen Chih-Mei Chen Peter S Chines Robert Clarke Lachlan Coin John Connell Ian N M Day Martin den Heijer Jubao Duan Shah Ebrahim Paul Elliott Roberto Elosua Gudny Eiriksdottir Michael R Erdos Johan G Eriksson Maurizio F Facheris Stephan B Felix Pamela Fischer-Posovszky Aaron R Folsom Nele Friedrich Nelson B Freimer Mao Fu Stefan Gaget Pablo V Gejman Eco J C Geus Christian Gieger Anette P Gjesing Anuj Goel Philippe Goyette Harald Grallert Jürgen Grässler Danielle M Greenawalt Christopher J Groves Vilmundur Gudnason Candace Guiducci Anna-Liisa Hartikainen Neelam Hassanali Alistair S Hall Aki S Havulinna Caroline Hayward Andrew C Heath Christian Hengstenberg Andrew A Hicks Anke Hinney Albert Hofman Georg Homuth Jennie Hui Wilmar Igl Carlos Iribarren Bo Isomaa Kevin B Jacobs Ivonne Jarick Elizabeth Jewell Ulrich John Torben Jørgensen Pekka Jousilahti Antti Jula Marika Kaakinen Eero Kajantie Lee M Kaplan Sekar Kathiresan Johannes Kettunen Leena Kinnunen Joshua W Knowles Ivana Kolcic Inke R König Seppo Koskinen Peter Kovacs Johanna Kuusisto Peter Kraft Kirsti Kvaløy Jaana Laitinen Olivier Lantieri Chiara Lanzani Lenore J Launer Cecile Lecoeur Terho Lehtimäki Guillaume Lettre Jianjun Liu Marja-Liisa Lokki Mattias Lorentzon Robert N Luben Barbara Ludwig Paolo Manunta Diana Marek Michel Marre Nicholas G Martin Wendy L McArdle Anne McCarthy Barbara McKnight Thomas Meitinger Olle Melander David Meyre Kristian Midthjell Grant W Montgomery Mario A Morken Andrew P Morris Rosanda Mulic Julius S Ngwa Mari Nelis Matt J Neville Dale R Nyholt Christopher J O'Donnell Stephen O'Rahilly Ken K Ong Ben Oostra Guillaume Paré Alex N Parker Markus Perola Irene Pichler Kirsi H Pietiläinen Carl G P Platou Ozren Polasek Anneli Pouta Suzanne Rafelt Olli Raitakari Nigel W Rayner Martin Ridderstråle Winfried Rief Aimo Ruokonen Neil R Robertson Peter Rzehak Veikko Salomaa Alan R Sanders Manjinder S Sandhu Serena Sanna Jouko Saramies Markku J Savolainen Susann Scherag Sabine Schipf Stefan Schreiber Heribert Schunkert Kaisa Silander Juha Sinisalo David S Siscovick Jan H Smit Nicole Soranzo Ulla Sovio Jonathan Stephens Ida Surakka Amy J Swift Mari-Liis Tammesoo Jean-Claude Tardif Maris Teder-Laving Tanya M Teslovich John R Thompson Brian Thomson Anke Tönjes Tiinamaija Tuomi Joyce B J van Meurs Gert-Jan van Ommen Vincent Vatin Jorma Viikari Sophie Visvikis-Siest Veronique Vitart Carla I G Vogel Benjamin F Voight Lindsay L Waite Henri Wallaschofski G Bragi Walters Elisabeth Widen Susanna Wiegand Sarah H Wild Gonneke Willemsen Daniel R Witte Jacqueline C Witteman Jianfeng Xu Qunyuan Zhang Lina Zgaga Andreas Ziegler Paavo Zitting John P Beilby I Sadaf Farooqi Johannes Hebebrand Heikki V Huikuri Alan L James Mika Kähönen Douglas F Levinson Fabio Macciardi Markku S Nieminen Claes Ohlsson Lyle J Palmer Paul M Ridker Michael Stumvoll Jacques S Beckmann Heiner Boeing Eric Boerwinkle Dorret I Boomsma Mark J Caulfield Stephen J Chanock Francis S Collins L Adrienne Cupples George Davey Smith Jeanette Erdmann Philippe Froguel Henrik Grönberg Ulf Gyllensten Per Hall Torben Hansen Tamara B Harris Andrew T Hattersley Richard B Hayes Joachim Heinrich Frank B Hu Kristian Hveem Thomas Illig Marjo-Riitta Jarvelin Jaakko Kaprio Fredrik Karpe Kay-Tee Khaw Lambertus A Kiemeney Heiko Krude Markku Laakso Debbie A Lawlor Andres Metspalu Patricia B Munroe Willem H Ouwehand Oluf Pedersen Brenda W Penninx Annette Peters Peter P Pramstaller Thomas Quertermous Thomas Reinehr Aila Rissanen Igor Rudan Nilesh J Samani Peter E H Schwarz Alan R Shuldiner Timothy D Spector Jaakko Tuomilehto Manuela Uda André Uitterlinden Timo T Valle Martin Wabitsch Gérard Waeber Nicholas J Wareham Hugh Watkins James F Wilson Alan F Wright M Carola Zillikens Nilanjan Chatterjee Steven A McCarroll Shaun Purcell Eric E Schadt Peter M Visscher Themistocles L Assimes Ingrid B Borecki Panos Deloukas Caroline S Fox Leif C Groop Talin Haritunians David J Hunter Robert C Kaplan Karen L Mohlke Jeffrey R O'Connell Leena Peltonen David Schlessinger David P Strachan Cornelia M van Duijn H-Erich Wichmann Timothy M Frayling Unnur Thorsteinsdottir Gonçalo R Abecasis Inês Barroso Michael Boehnke Kari Stefansson Kari E North Mark I McCarthy Joel N Hirschhorn Erik Ingelsson Ruth J F Loos

Nat Genet 2010 Nov 10;42(11):937-48. Epub 2010 Oct 10.

Metabolism Initiative and Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA.

View Article

Download full-text PDF

Source
http://www.genome.gov/pages/research/dir/bmistudy.pdf
Web Search
http://www.nature.com/doifinder/10.1038/ng.686
Publisher Site
http://dx.doi.org/10.1038/ng.686DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3014648PMC
November 2010

A new phenotype of nongoitrous and nonautoimmune hyperthyroidism caused by a heterozygous thyrotropin receptor mutation in transmembrane helix 6.

J Clin Endocrinol Metab 2010 Aug 25;95(8):3605-10. Epub 2010 May 25.

Institute of Experimental Pediatric Endocrinology, Charité Universitätsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1210/jc.2010-0112DOI Listing
August 2010

Heterodimerization of hypothalamic G-protein-coupled receptors involved in weight regulation.

Obes Facts 2009 9;2(2):80-6. Epub 2009 Apr 9.

Institute of Experimental Pediatric Endocrinology, Charité - Universitatsmedizin Berlin, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000209862DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444828PMC
July 2010

Genetic defects, thyroid growth and malfunctions of the TSHR in pediatric patients.

Front Biosci (Landmark Ed) 2010 Jun 1;15:913-33. Epub 2010 Jun 1.

Institute of Experimental Pediatric Endocrinology, Charite Universitatsmedizin Berlin, Augustenburger Platz, Berlin, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2741/3654DOI Listing
June 2010

Surface translocation and tri-iodothyronine uptake of mutant MCT8 proteins are cell type-dependent.

J Mol Endocrinol 2009 Dec 31;43(6):263-71. Epub 2009 Jul 31.

Institute for Experimental Endocrinology Institute for Experimental Pediatric Endocrinology, Charité-Universitätsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1677/JME-09-0043DOI Listing
December 2009

A novel melanocortin-4 receptor gene mutation in a female patient with severe childhood obesity.

Endocrine 2009 Aug 12;36(1):52-9. Epub 2009 Feb 12.

Division of Endocrinology, Seattle Children's Hospital Research Institute, Seattle, WA 98101, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12020-009-9156-4DOI Listing
August 2009

Lifestyle intervention in obese children with variations in the melanocortin 4 receptor gene.

Obesity (Silver Spring) 2009 Feb 6;17(2):382-9. Epub 2008 Nov 6.

Department of Pediatric Nutrition Medicine, Vestische Hospital for Children and Adolescents Datteln, University of Witten/Herdecke, Datteln, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/oby.2008.422DOI Listing
February 2009

Increased constraints on MC4R during primate and human evolution.

Hum Genet 2009 Jan 15;124(6):633-47. Epub 2008 Nov 15.

Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00439-008-0591-8DOI Listing
January 2009

V2 vasopressin receptor deficiency causes changes in expression and function of renal and hypothalamic components involved in electrolyte and water homeostasis.

Am J Physiol Renal Physiol 2008 Oct 20;295(4):F1177-90. Epub 2008 Aug 20.

Institute of Biochemistry, Molecular Biochemistry, Medical Faculty, University of Leipzig, Johannisallee 30, 04103 Leipzig, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1152/ajprenal.00465.2007DOI Listing
October 2008

G13-dependent activation of MAPK by thyrotropin.

J Biol Chem 2008 Jul 29;283(29):20330-41. Epub 2008 Apr 29.

Institut für Pharmakologie und Toxikologie, Philipps-Universität, Karl-von-Frisch-Strasse 1, Marburg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M800211200DOI Listing
July 2008

Evolutionary aspects in evaluating mutations in the melanocortin 4 receptor.

Endocrinology 2007 Oct 12;148(10):4642-8. Epub 2007 Jul 12.

Institute of Biochemistry, Molecular Biochemistry, Medical Faculty, University of Leipzig, Johannisallee 30, 04103 Leipzig, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1210/en.2007-0138DOI Listing
October 2007

MC4R oligomerizes independently of extracellular cysteine residues.

Peptides 2006 Feb 9;27(2):372-9. Epub 2005 Nov 9.

Otto Heubner Centrum für Kinderheilkunde und Jugendmedizin, Pädiatrische Endokrinologie, Campus Virchow-Klinikum, Charité-Universitätsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.peptides.2005.02.027DOI Listing
February 2006

A role for beta-melanocyte-stimulating hormone in human body-weight regulation.

Cell Metab 2006 Feb;3(2):141-6

Institute for Pediatric Endocrinology, Charité Universitätsmedizin Berlin, 13353 Berlin, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cmet.2006.01.007DOI Listing
February 2006

Extended clinical phenotype, endocrine investigations and functional studies of a loss-of-function mutation A150V in the thyroid hormone specific transporter MCT8.

Eur J Endocrinol 2005 Sep;153(3):359-66

Department of Pediatric Endocrinology, Charité Children's Hospital, Humboldt University Berlin, Augustenburger Platz 1, 13353 Berlin, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1530/eje.1.01980DOI Listing
September 2005

Mutant G-protein-coupled receptors as a cause of human diseases.

Pharmacol Ther 2004 Dec;104(3):173-206

Institute of Biochemistry, Department of Molecular Biochemistry (Max-Planck-Institute Interim), Medical Faculty, University of Leipzig, Deutscher Platz 6, 04103 Leipzig, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.pharmthera.2004.08.008DOI Listing
December 2004

Molecular genetic defects in congenital hypothyroidism.

Eur J Endocrinol 2004 Nov;151 Suppl 3:U39-44

Paediatric Endocrinology, University Children's Hospital Charite, Augustenburger Platz 1, 13353 Berlin, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1530/eje.0.151u039DOI Listing
November 2004