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A streamlined protocol for the detection of mRNA-sRNA interactions using AMT-crosslinking .

Biotechniques 2019 Oct 29;67(4):178-183. Epub 2019 Aug 29.

Institute for Biochemistry, Brüderstraße 34, 04103 Leipzig, Germany.

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http://dx.doi.org/10.2144/btn-2019-0047DOI Listing
October 2019

Dual expression of CCA-adding enzyme and RNase T in Escherichia coli generates a distinct cca growth phenotype with diverse applications.

Nucleic Acids Res 2019 04;47(7):3631-3639

Institute for Biochemistry, Leipzig University, Brüderstr. 34, 04103 Leipzig, Germany.

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http://dx.doi.org/10.1093/nar/gkz133DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468291PMC
April 2019

A Temporal Order in 5'- and 3'- Processing of Eukaryotic tRNA.

Int J Mol Sci 2019 Mar 19;20(6). Epub 2019 Mar 19.

Institute for Biochemistry, Leipzig University, Brüderstraße 34, 04103 Leipzig, Germany.

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http://dx.doi.org/10.3390/ijms20061384DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6470698PMC
March 2019

Combining crystallogenesis methods to produce diffraction-quality crystals of a psychrophilic tRNA-maturation enzyme.

Acta Crystallogr F Struct Biol Commun 2018 Nov 31;74(Pt 11):747-753. Epub 2018 Oct 31.

Architecture et Réactivité de l'ARN, UPR 9002, Université de Strasbourg, IBMC, CNRS, 15 Rue R. Descartes, 67084 Strasbourg, France.

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http://scripts.iucr.org/cgi-bin/paper?S2053230X18014590
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http://dx.doi.org/10.1107/S2053230X18014590DOI Listing
November 2018

A tRNA's fate is decided at its 3' end: Collaborative actions of CCA-adding enzyme and RNases involved in tRNA processing and degradation.

Biochim Biophys Acta Gene Regul Mech 2018 Apr 31;1861(4):433-441. Epub 2018 Jan 31.

Institute for Biochemistry, Leipzig University, Brüderstr. 34, 04103 Leipzig, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.bbagrm.2018.01.012DOI Listing
April 2018

Examining tRNA 3'-ends in : teamwork between CCA-adding enzyme, RNase T, and RNase R.

RNA 2018 03 27;24(3):361-370. Epub 2017 Nov 27.

Institute for Biochemistry, Leipzig University, Leipzig 04103, Germany.

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http://dx.doi.org/10.1261/rna.064436.117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5824355PMC
March 2018

Cold adaptation of tRNA nucleotidyltransferases: A tradeoff in activity, stability and fidelity.

RNA Biol 2018 01 21;15(1):144-155. Epub 2017 Nov 21.

a Institute for Biochemistry, University of Leipzig , Leipzig , Germany.

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http://dx.doi.org/10.1080/15476286.2017.1391445DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5785979PMC
January 2018

Erratum to: Genotyping bacterial and fungal pathogens using sequence variation in the gene for the CCA-adding enzyme.

BMC Microbiol 2016 Sep 21;16(1):219. Epub 2016 Sep 21.

Institute for Biochemistry, Leipzig University, Brüderstr. 34, 04103, Leipzig, Germany.

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http://bmcmicrobiol.biomedcentral.com/articles/10.1186/s1286
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http://dx.doi.org/10.1186/s12866-016-0841-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5030726PMC
September 2016

Genotyping bacterial and fungal pathogens using sequence variation in the gene for the CCA-adding enzyme.

BMC Microbiol 2016 Mar 18;16:47. Epub 2016 Mar 18.

Institute for Biochemistry, Leipzig University, Brüderstr. 34, 04103, Leipzig, Germany.

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http://dx.doi.org/10.1186/s12866-016-0670-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4797355PMC
March 2016

The CCA-adding enzyme: A central scrutinizer in tRNA quality control.

Bioessays 2015 Sep 14;37(9):975-82. Epub 2015 Jul 14.

Institute for Biochemistry, University of Leipzig, Leipzig, Germany.

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http://doi.wiley.com/10.1002/bies.201500043
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http://dx.doi.org/10.1002/bies.201500043DOI Listing
September 2015

The ancestor of modern Holozoa acquired the CCA-adding enzyme from Alphaproteobacteria by horizontal gene transfer.

Nucleic Acids Res 2015 Aug 27;43(14):6739-46. Epub 2015 Jun 27.

Computational EvoDevo Group, Department of Computer Science, University of Leipzig, Härtelstraße 16-18, D-04107 Leipzig, Germany Interdisciplinary Center for Bioinformatics, University of Leipzig, Härtelstraße 16-18, D-04107 Leipzig, Germany

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http://dx.doi.org/10.1093/nar/gkv631DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4538823PMC
August 2015

The identity of the discriminator base has an impact on CCA addition.

Nucleic Acids Res 2015 Jun 9;43(11):5617-29. Epub 2015 May 9.

Institute for Biochemistry, University of Leipzig, Brüderstrasse 34, 04103 Leipzig, Germany

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http://dx.doi.org/10.1093/nar/gkv471DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4477674PMC
June 2015

From end to end: tRNA editing at 5'- and 3'-terminal positions.

Int J Mol Sci 2014 Dec 22;15(12):23975-98. Epub 2014 Dec 22.

Institute for Biochemistry, University of Leipzig, Brüderstraße 34, 04103 Leipzig, Germany.

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http://dx.doi.org/10.3390/ijms151223975DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4284800PMC
December 2014

The TRAMP complex shows tRNA editing activity in S. cerevisiae.

Mol Biol Evol 2012 May 19;29(5):1451-9. Epub 2011 Dec 19.

Institute for Biochemistry, University of Leipzig, Leipzig, Germany.

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http://dx.doi.org/10.1093/molbev/msr312DOI Listing
May 2012

An inhibitory C-terminal region dictates the specificity of A-adding enzymes.

Proc Natl Acad Sci U S A 2011 Dec 13;108(52):21040-5. Epub 2011 Dec 13.

Institute for Biochemistry, University of Leipzig, Brüderstrasse 34, 04103 Leipzig, Germany.

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http://dx.doi.org/10.1073/pnas.1116117108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3248509PMC
December 2011

Unusual evolution of a catalytic core element in CCA-adding enzymes.

Nucleic Acids Res 2010 Jul 25;38(13):4436-47. Epub 2010 Mar 25.

Institute for Biochemistry, University of Leipzig, Brüderstr. 34, 04103 Leipzig, Germany.

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http://dx.doi.org/10.1093/nar/gkq176DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2910056PMC
July 2010

tRNA nucleotidyltransferases: ancient catalysts with an unusual mechanism of polymerization.

Cell Mol Life Sci 2010 May 14;67(9):1447-63. Epub 2010 Feb 14.

Institute for Biochemistry, University of Leipzig, Brüderstr. 34, 04103 Leipzig, Germany.

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http://dx.doi.org/10.1007/s00018-010-0271-4DOI Listing
May 2010

Evolution of tRNA nucleotidyltransferases: a small deletion generated CC-adding enzymes.

Proc Natl Acad Sci U S A 2008 Jun 3;105(23):7953-8. Epub 2008 Jun 3.

Institute for Biochemistry, University of Leipzig, Brüderstrasse 34, 04103 Leipzig, Germany.

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http://dx.doi.org/10.1073/pnas.0801971105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2430343PMC
June 2008

A comparative analysis of CCA-adding enzymes from human and E. coli: differences in CCA addition and tRNA 3'-end repair.

Biochimie 2008 May 5;90(5):762-72. Epub 2008 Jan 5.

University of Leipzig, Institute for Biochemistry, Brüderstrasse 34, D-04103 Leipzig, Germany.

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http://dx.doi.org/10.1016/j.biochi.2007.12.007DOI Listing
May 2008

Hfq stimulates the activity of the CCA-adding enzyme.

BMC Mol Biol 2007 Oct 18;8:92. Epub 2007 Oct 18.

Institute for Biochemistry, University of Leipzig, Brüderstr, 34, 04103 Leipzig, Germany.

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http://bmcmolbiol.biomedcentral.com/articles/10.1186/1471-21
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http://dx.doi.org/10.1186/1471-2199-8-92DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2175515PMC
October 2007

Is yeast on its way to evolving tRNA editing?

EMBO Rep 2005 Apr;6(4):367-72

Max-Planck-Institute for Evolutionary Anthropology, Deutscher Platz 6, 04103 Leipzig, Germany.

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http://dx.doi.org/10.1038/sj.embor.7400381DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1299291PMC
April 2005

Aptamers that recognize the lipid moiety of the antibiotic moenomycin A.

Biol Chem 2003 Oct-Nov;384(10-11):1497-500

Universität Hamburg, Abteilung Biochemie und Molekularbiologie, Martin-Luther-King-Platz 6, D-20146 Hamburg, Germany.

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https://www.degruyter.com/view/j/bchm.2003.384.issue-10-11/b
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http://dx.doi.org/10.1515/BC.2003.165DOI Listing
October 2004

Exchange of regions between bacterial poly(A) polymerase and the CCA-adding enzyme generates altered specificities.

Mol Cell 2004 Aug;15(3):389-98

Max-Planck-Institute for Evolutionary Anthropology, Deutscher Platz 6, D-04103 Leipzig, Germany.

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http://dx.doi.org/10.1016/j.molcel.2004.06.026DOI Listing
August 2004

Crystal structure of the human CCA-adding enzyme: insights into template-independent polymerization.

J Mol Biol 2003 May;328(5):985-94

Max-Planck-Institut für Biochemie, Abteilung Strukturforschung, Am Klopferspitz 18A, D-82152 Martinsried, Germany.

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http://dx.doi.org/10.1016/s0022-2836(03)00381-4DOI Listing
May 2003