Publications by authors named "Heidi S Phillips"

31Publications

Brain Distribution and Efficacy of the Brain Penetrant PI3K Inhibitor GDC-0084 in Orthotopic Mouse Models of Human Glioblastoma.

Drug Metab Dispos 2016 12 16;44(12):1881-1889. Epub 2016 Sep 16.

Departments of Drug Metabolism and Pharmacokinetics (L.S., S.S.-L., J.C., J.P., E.G.P., C.Q., X.Z.), Discovery Chemistry (T.P.H., A.G.O.), Cancer Signaling and Translational Oncology (B.A., M.N., M.N.-P., L.B.L., S.E.G., H.S.P.), Biomedical Imaging (T.C., R.A.C., J.G.), and Pathology (H.K., S.L., L.R.), Genentech Inc., South San Francisco, California.

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http://dx.doi.org/10.1124/dmd.116.071423DOI Listing
December 2016

Impact of Blood-Brain Barrier Integrity on Tumor Growth and Therapy Response in Brain Metastases.

Clin Cancer Res 2016 Dec 12;22(24):6078-6087. Epub 2016 Aug 12.

Neurology Clinic and National Center for Tumor Diseases, University Hospital Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1158/1078-0432.CCR-16-1327DOI Listing
December 2016

Reply to T.J. Kruser et al.

J Clin Oncol 2016 Apr 16;34(11):1282-3. Epub 2016 Feb 16.

University of California, Los Angeles, Los Angeles, CA.

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http://dx.doi.org/10.1200/JCO.2015.65.2438DOI Listing
April 2016

Patients With Proneural Glioblastoma May Derive Overall Survival Benefit From the Addition of Bevacizumab to First-Line Radiotherapy and Temozolomide: Retrospective Analysis of the AVAglio Trial.

J Clin Oncol 2015 Sep 29;33(25):2735-44. Epub 2015 Jun 29.

Thomas Sandmann, Richard Bourgon, Congfen Li, Samir Kharbanda, Franklin Peale, Priti Hegde, Heidi S. Phillips, and Carlos Bais, Genentech, South San Francisco; Timothy Cloughesy and Albert Lai, University of California Los Angeles, Los Angeles, CA; Josep Garcia, Nicola Moore, and Lauren E. Abrey F. Hoffmann-La Roche, Basel, Switzerland; Olivier L. Chinot, Aix-Marseille University, Assistance Publique-Hôpitaux de Marseille, Centre Hospitalier Universitaire Timone, Marseille, France; Wolfgang Wick, University Medical Center, Heidelberg, Germany; Ryo Nishikawa, Saitama Medical University, Saitama, Japan; Warren Mason, Princess Margaret Hospital, Toronto, Ontario, Canada; Roger Henriksson, Regional Cancer Center Stockholm, Stockholm; and Umeå University, Umeå, Sweden; and Frank Saran, Royal Marsden National Health Service Foundation Trust, Surrey, United Kingdom.

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http://ascopubs.org/doi/10.1200/JCO.2015.61.5005
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http://dx.doi.org/10.1200/JCO.2015.61.5005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5015426PMC
September 2015

Distribution of the phosphatidylinositol 3-kinase inhibitors Pictilisib (GDC-0941) and GNE-317 in U87 and GS2 intracranial glioblastoma models-assessment by matrix-assisted laser desorption ionization imaging.

Drug Metab Dispos 2014 Jul 22;42(7):1110-6. Epub 2014 Apr 22.

Departments of Drug Metabolism and Pharmacokinetics (L.S., S.S-L., C.Q., J.P.), Biomedical Imaging (K.B., R.A.C.), Cancer Signaling and Translational Oncology (M.N., B.A., H.S.P.), and Chemistry (A.G.O.), Genentech, Inc., South San Francisco, California.

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http://dx.doi.org/10.1124/dmd.114.057513DOI Listing
July 2014

Overexpression of isocitrate dehydrogenase mutant proteins renders glioma cells more sensitive to radiation.

Neuro Oncol 2013 Jan 31;15(1):57-68. Epub 2012 Oct 31.

Department of Neurology, David Geffen School of Medicine at UCLA, University of California at Los Angeles, Los Angeles, California 90095, USA.

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http://dx.doi.org/10.1093/neuonc/nos261DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3534418PMC
January 2013

Molecular subclassification of diffuse gliomas: seeing order in the chaos.

Glia 2011 Aug 28;59(8):1190-9. Epub 2011 Mar 28.

Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, USA.

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http://dx.doi.org/10.1002/glia.21165DOI Listing
August 2011

Reversing HOXA9 oncogene activation by PI3K inhibition: epigenetic mechanism and prognostic significance in human glioblastoma.

Cancer Res 2010 Jan 12;70(2):453-62. Epub 2010 Jan 12.

The Brain Tumor Research Center, Department of Neurological Surgery, University of California-San Francisco, San Francisco, California 94158-9001, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-09-2189DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2849935PMC
January 2010

Epigenome scans and cancer genome sequencing converge on WNK2, a kinase-independent suppressor of cell growth.

Proc Natl Acad Sci U S A 2007 Jun 19;104(26):10974-9. Epub 2007 Jun 19.

*Department of Neurological Surgery and the Comprehensive Cancer Center, University of California, San Francisco, CA 94143.

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http://dx.doi.org/10.1073/pnas.0700683104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1904113PMC
June 2007

Identification of IGF2 signaling through phosphoinositide-3-kinase regulatory subunit 3 as a growth-promoting axis in glioblastoma.

Proc Natl Acad Sci U S A 2007 Feb 20;104(9):3466-71. Epub 2007 Feb 20.

Department of Tumor Biology and Angiogenesis, Molecular Biology, Biostatistics, and Pathology, Genentech, Inc., South San Francisco, CA 94080, USA.

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http://dx.doi.org/10.1073/pnas.0611271104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1802005PMC
February 2007

Hippocampal dysfunction and behavioral deficit in the water maze in mice: an unresolved issue?

Brain Res Bull 2002 Jan;57(1):3-9

Genentech, Inc. Neuroscience Department, San Francisco, CA, USA.

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http://dx.doi.org/10.1016/s0361-9230(01)00630-xDOI Listing
January 2002