Heidi H Yu

In vitro pharmacokinetics/pharmacodynamics of continuous ceftazidime infusion alone and in combination with colistin against Pseudomonas aeruginosa biofilm.

Authors:

Joan Gómez-Junyent Oscar Murillo Heidi H Yu Mohammad A K Azad Hasini Wickremasinghe Raul Rigo-Bonnin Eva Benavent Javier Ariza Jian Li

Int J Antimicrob Agents 2020 Nov 28:106246. Epub 2020 Nov 28.

Monash Biomedicine Discovery Institute, Department of Microbiology, Monash University, Victoria, Australia.

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November 2020

Polymyxins Bind to the Cell Surface of Unculturable and Cause Unique Dependent Resistance.

Adv Sci (Weinh) 2020 Aug 8;7(15):2000704. Epub 2020 Jun 8.

Infection & Immunity Program Biomedicine Discovery Institute and Department of Microbiology Monash University Melbourne 3800 Australia.

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August 2020

Transcriptomic responses of a New Delhi metallo-β-lactamase-producing Klebsiella pneumoniae isolate to the combination of polymyxin B and chloramphenicol.

Authors:

Nusaibah Abdul Rahim Soon-Ee Cheah Matthew D Johnson Yan Zhu Heidi H Yu Hanna E Sidjabat Mark S Butler Matthew A Cooper Jing Fu David L Paterson Roger L Nation John D Boyce Phillip J Bergen Tony Velkov Jian Li

Int J Antimicrob Agents 2020 Aug 20;56(2):106061. Epub 2020 Jun 20.

Biomedicine Discovery Institute, Infection and Immunity Program and Department of Microbiology, Monash University, Melbourne, Victoria, Australia. Electronic address:

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August 2020

Complete genome sequence and genome-scale metabolic modelling of Acinetobacter baumannii type strain ATCC 19606.

Authors:

Yan Zhu Jing Lu Jinxin Zhao Xinru Zhang Heidi H Yu Tony Velkov Jian Li

Int J Med Microbiol 2020 Apr 5;310(3):151412. Epub 2020 Feb 5.

Biomedicine Discovery Institute, Infection & Immunity Program and Department of Microbiology, Monash University, Melbourne, VIC, 3800, Australia. Electronic address:

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April 2020

Multifaceted mechanisms of colistin resistance revealed by genomic analysis of multidrug-resistant Klebsiella pneumoniae isolates from individual patients before and after colistin treatment.

Authors:

Yan Zhu Irene Galani Ilias Karaiskos Jing Lu Su Mon Aye Jiayuan Huang Heidi H Yu Tony Velkov Helen Giamarellou Jian Li

J Infect 2019 10 30;79(4):312-321. Epub 2019 Jul 30.

Monash Biomedicine Discovery Institute, Infection and Immunity Program and Department of Microbiology, Monash University, Melbourne 3800, Australia. Electronic address:

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October 2019

Polymyxin resistance in Klebsiella pneumoniae: multifaceted mechanisms utilized in the presence and absence of the plasmid-encoded phosphoethanolamine transferase gene mcr-1.

Authors:

Sue C Nang Mei-Ling Han Heidi H Yu Jiping Wang Von Vergel L Torres Chongshan Dai Tony Velkov Marina Harper Jian Li

J Antimicrob Chemother 2019 11;74(11):3190-3198

Department of Microbiology, Infection and Immunity Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.

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November 2019

Comparative Metabolomics Reveals Key Pathways Associated With the Synergistic Killing of Colistin and Sulbactam Combination Against Multidrug-Resistant .

Authors:

Mei-Ling Han Xiaofen Liu Tony Velkov Yu-Wei Lin Yan Zhu Darren J Creek Christopher K Barlow Heidi H Yu Zhihui Zhou Jing Zhang Jian Li

Front Pharmacol 2019 4;10:754. Epub 2019 Jul 4.

Biomedicine Discovery Institute, Infection and Immunity Program, Department of Microbiology, Monash University, Clayton, VIC, Australia.

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July 2019

Effects of the antibiotic component on in-vitro bacterial killing, physico-chemical properties, aerosolization and dissolution of a ternary-combinational inhalation powder formulation of antibiotics for pan-drug resistant Gram-negative lung infections.

Authors:

Sharad Mangal Jiayang Huang Nivedita Shetty Heejun Park Yu-Wei Lin Heidi H Yu Dmitry Zemlyanov Tony Velkov Jian Li Qi Tony Zhou

Int J Pharm 2019 Apr 21;561:102-113. Epub 2019 Feb 21.

Department of Industrial and Physical Pharmacy, College of Pharmacy, Purdue University, 575 Stadium Mall Drive, West Lafayette, IN 47907, USA. Electronic address:

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April 2019

Novel Polymyxin Combination with the Antiretroviral Zidovudine Exerts Synergistic Killing against NDM-Producing Multidrug-Resistant Klebsiella pneumoniae.

Authors:

Yu-Wei Lin Nusaibah Abdul Rahim Jinxin Zhao Mei-Ling Han Heidi H Yu Hasini Wickremasinghe Ke Chen Jiping Wang David L Paterson Yan Zhu Gauri G Rao Qi Tony Zhou Alan Forrest Tony Velkov Jian Li

Antimicrob Agents Chemother 2019 04 27;63(4). Epub 2019 Mar 27.

Monash Biomedicine Discovery Institute, Infection and Immunity Program and Department of Microbiology, Monash University, Clayton, Victoria, Australia

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April 2019

Metabolic Analyses Revealed Time-Dependent Synergistic Killing by Colistin and Aztreonam Combination Against Multidrug-Resistant .

Authors:

Mei-Ling Han Xiaofen Liu Tony Velkov Yu-Wei Lin Yan Zhu Mengyao Li Heidi H Yu Zhihui Zhou Darren J Creek Jing Zhang Jian Li

Front Microbiol 2018 16;9:2776. Epub 2018 Nov 16.

Biomedicine Discovery Institute, Infection and Immunity Program, Department of Microbiology, Monash University, Clayton, VIC, Australia.

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November 2018

Discovery of -Mediated Colistin Resistance in a Highly Virulent Escherichia coli Lineage.

Authors:

Brian M Forde Hosam M Zowawi Patrick N A Harris Leah Roberts Emad Ibrahim Nissar Shaikh Anand Deshmukh Mazen A Sid Ahmed Muna Al Maslamani Kyra Cottrell Ella Trembizki Lana Sundac Heidi H Yu Jian Li Mark A Schembri David M Whiley David L Paterson Scott A Beatson

mSphere 2018 10 10;3(5). Epub 2018 Oct 10.

School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Queensland, Australia

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October 2018

Co-Delivery of Ciprofloxacin and Colistin in Liposomal Formulations with Enhanced In Vitro Antimicrobial Activities against Multidrug Resistant Pseudomonas aeruginosa.

Authors:

Shaoning Wang Shihui Yu Yuwei Lin Peizhi Zou Guihong Chai Heidi H Yu Hasini Wickremasinghe Nivedita Shetty Junhong Ling Jian Li Qi Tony Zhou

Pharm Res 2018 Aug 9;35(10):187. Epub 2018 Aug 9.

Department of Industrial and Physical Pharmacy, College of Pharmacy, Purdue University, 575 Stadium Mall Drive, West Lafayette, Indiana, 47907, USA.

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August 2018

Composite particle formulations of colistin and meropenem with improved in-vitro bacterial killing and aerosolization for inhalation.

Authors:

Sharad Mangal Heejun Park Lingfei Zeng Heidi H Yu Yu-Wei Lin Tony Velkov John A Denman Dmitry Zemlyanov Jian Li Qi Tony Zhou

Int J Pharm 2018 Sep 3;548(1):443-453. Epub 2018 Jul 3.

Department of Industrial and Physical Pharmacy, College of Pharmacy, Purdue University, 575 Stadium Mall Drive, West Lafayette, IN 47907, USA. Electronic address:

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September 2018

Polymyxin B in Combination with Enrofloxacin Exerts Synergistic Killing against Extensively Drug-Resistant Pseudomonas aeruginosa.

Authors:

Yu-Wei Lin Heidi H Yu Jinxin Zhao Mei-Ling Han Yan Zhu Jesmin Akter Hasini Wickremasinghe Hasini Walpola Veronika Wirth Gauri G Rao Alan Forrest Tony Velkov Jian Li

Antimicrob Agents Chemother 2018 06 25;62(6). Epub 2018 May 25.

Monash Biomedicine Discovery Institute, Department of Microbiology, Monash University, Clayton, Victoria, Australia

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June 2018

Corrigendum to "Structure, folding and stability of a minimal homologue from Anemonia sulcata of the sea anemone potassium channel blocker ShK" [Peptides 99 (2018) 169-178].

Authors:

Bankala Krishnarjuna Christopher A MacRaild Punnepalli Sunanda Rodrigo A V Morales Steve Peigneur Jason Macrander Heidi H Yu Marymegan Daly Srinivasarao Raghothama Vikas Dhawan Satendra Chauhan Jan Tytgat Michael W Pennington Raymond S Norton

Peptides 2018 03 1;101:234. Epub 2018 Feb 1.

Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade,Parkville, VIC 3052, Australia. Electronic address:

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March 2018

Structure, folding and stability of a minimal homologue from Anemonia sulcata of the sea anemone potassium channel blocker ShK.

Authors:

Bankala Krishnarjuna Christopher A MacRaild Punnepalli Sunanda Rodrigo A V Morales Steve Peigneur Jason Macrander Heidi H Yu Marymegan Daly Srinivasarao Raghothama Vikas Dhawan Satendra Chauhan Jan Tytgat Michael W Pennington Raymond S Norton

Peptides 2018 01 6;99:169-178. Epub 2017 Oct 6.

Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, VIC 3052, Australia. Electronic address:

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January 2018

The first total synthesis and solution structure of a polypeptin, PE2, a cyclic lipopeptide with broad spectrum antibiotic activity.

Authors:

Simon J Mountford Biswaranjan Mohanty Kade D Roberts Heidi H Yu Martin J Scanlon Roger L Nation Tony Velkov Jian Li Philp E Thompson

Org Biomol Chem 2017 Aug;15(34):7173-7180

Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville 3052, Australia.

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August 2017

A Novel Chemical Biology Approach for Mapping of Polymyxin Lipopeptide Antibody Binding Epitopes.

Authors:

Tony Velkov Bo Yun Elena K Schneider Mohammad A K Azad Olan Dolezal Faye C Morris Roger L Nation Jiping Wang Ke Chen Heidi H Yu Lv Wang Philip E Thompson Kade D Roberts Jian Li

ACS Infect Dis 2016 05 29;2(5):341-51. Epub 2016 Mar 29.

CSIRO Manufacturing , Parkville, Victoria 3052, Australia.

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May 2016

Anthelmintic closantel enhances bacterial killing of polymyxin B against multidrug-resistant Acinetobacter baumannii.

Authors:

Thien B Tran Soon-Ee Cheah Heidi H Yu Phillip J Bergen Roger L Nation Darren J Creek Anthony Purcell Alan Forrest Yohei Doi Jiangning Song Tony Velkov Jian Li

J Antibiot (Tokyo) 2016 06 16;69(6):415-21. Epub 2015 Dec 16.

Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Melbourne, Australia.

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June 2016

Significant accumulation of polymyxin in single renal tubular cells: a medicinal chemistry and triple correlative microscopy approach.

Authors:

Mohammad A K Azad Kade D Roberts Heidi H Yu Boyin Liu Alice V Schofield Simon A James Daryl L Howard Roger L Nation Kelly Rogers Martin D de Jonge Philip E Thompson Jing Fu Tony Velkov Jian Li

Anal Chem 2015 Feb 15;87(3):1590-5. Epub 2015 Jan 15.

Drug Delivery, Disposition and Dynamics, and ‡Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University , Parkville, Victoria 3052, Australia.

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February 2015

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