Publications by authors named "Hee-Jun Na"

29Publications

Antibody-Based Targeting of Cell Surface GRP94 Specifically Inhibits Cetuximab-Resistant Colorectal Cancer Growth.

Authors:
Mee Hyun Jeoung Taek-Keun Kim Ji Woong Kim Yea Bin Cho Hee Jun Na Byong Chul Yoo Hyunbo Shim Dong-Keun Song Kyun Heo Sukmook Lee

Biomolecules 2019 11 1;9(11). Epub 2019 Nov 1.

Biopharmaceutical Chemistry Major, School of Applied Chemistry, Kookmin University, Seoul 02707, Korea.

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November 2019

TSPYL5-mediated inhibition of p53 promotes human endothelial cell function.

Authors:
Hee-Jun Na Chung Eun Yeum Han-Seop Kim Jungwoon Lee Jae Yun Kim Yee Sook Cho

Angiogenesis 2019 05 23;22(2):281-293. Epub 2018 Nov 23.

Stem Cell Research Laboratory, Immunotherapy Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology, 125 Gwahak-ro, Yuseong-gu, Taejon, 34141, Republic of Korea.

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May 2019

Necroptosis Is a Mechanism of Death in Mouse Induced Hepatocyte-Like Cells Reprogrammed from Mouse Embryonic Fibroblasts.

Authors:
Yun-Suk Lee Kyung-Mee Park Lina Yu Ho-Hyun Kwak Hee-Jun Na Kyung-Sun Kang Heung-Myong Woo

Mol Cells 2018 Jul 10;41(7):639-645. Epub 2018 Jul 10.

College of Veterinary Medicine, Kangwon National University, Chuncheon 24341, Korea.

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July 2018

Inhibition of VEGF-dependent angiogenesis and tumor angiogenesis by an optimized antibody targeting CLEC14a.

Authors:
Taek-Keun Kim Chang Sik Park Jihye Jang Mi Ra Kim Hee-Jun Na Kangseung Lee Hyun Jung Kim Kyun Heo Byong Chul Yoo Young-Myeong Kim Je-Wook Lee Su Jin Kim Eun Sung Kim Dae Young Kim Kiweon Cha Tae Gyu Lee Sukmook Lee

Mol Oncol 2018 03 26;12(3):356-372. Epub 2018 Jan 26.

Scripps Korea Antibody Institute, Chuncheon, South Korea.

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March 2018

A Review of Anti-Angiogenic Targets for Monoclonal Antibody Cancer Therapy.

Authors:
Deok-Hoon Kong Mi Ra Kim Ji Hye Jang Hee-Jun Na Sukmook Lee

Int J Mol Sci 2017 Aug 17;18(8). Epub 2017 Aug 17.

Research Center, Scripps Korea Antibody Institute, Chuncheon 200-701, Korea.

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August 2017

Ig-like domain 6 of VCAM-1 is a potential therapeutic target in TNFα-induced angiogenesis.

Authors:
Taek-Keun Kim Chang Sik Park Hee-Jun Na Kangseung Lee Aerin Yoon Junho Chung Sukmook Lee

Exp Mol Med 2017 02 17;49(2):e294. Epub 2017 Feb 17.

Laboratory of Molecular Cancer Therapeutics, Research Center, Scripps Korea Antibody Institute, Chuncheon, Republic of Korea.

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February 2017

Biomarker Discovery by Modeling Behçet's Disease with Patient-Specific Human Induced Pluripotent Stem Cells.

Authors:
Mi-Young Son Young-Dae Kim Binna Seol Mi-Ok Lee Hee-Jun Na Bin Yoo Jae-Suk Chang Yee Sook Cho

Stem Cells Dev 2017 01 16;26(2):133-145. Epub 2016 Nov 16.

2 Department of Functional Genomics, University of Science and Technology , Daejeon, Republic of Korea.

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January 2017

Heat shock protein 70-1A is a novel angiogenic regulator.

Authors:
Taek-Keun Kim Hee Jun Na Woo Ran Lee Mee Hyun Jeoung Sukmook Lee

Biochem Biophys Res Commun 2016 Jan 30;469(2):222-8. Epub 2015 Nov 30.

Scripps Korea Antibody Institute, Hyoja-2-dong, Chuncheon-si, Gangwon-do, 200-701, South Korea. Electronic address:

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January 2016

Extension of the in vivo half-life of endostatin and its improved anti-tumor activities upon fusion to a humanized antibody against tumor-associated glycoprotein 72 in a mouse model of human colorectal carcinoma.

Authors:
Sang-Hyun Lee In Cheul Jeung Tae Woo Park Kyungmin Lee Dong Gwang Lee Young-Lai Cho Tae Sup Lee Hee-Jun Na Young-Jun Park Hee Gu Lee Mun Sik Jeong Kwang-Hee Bae Sang Chul Lee Hyo Jin Lee Young-Guen Kwon Hyo Jeong Hong Jang-Seong Kim Jeong-Ki Min

Oncotarget 2015 Mar;6(9):7182-94

Functional Genomics Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Republic of Korea.

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March 2015

TXNIP deficiency exacerbates endotoxic shock via the induction of excessive nitric oxide synthesis.

Authors:
Young-Jun Park Sung-Jin Yoon Hyun-Woo Suh Dong Oh Kim Jeong-Ran Park Haiyoung Jung Tae-Don Kim Suk Ran Yoon Jeong-Ki Min Hee-Jun Na Seon-Jin Lee Hee Gu Lee Young Ho Lee Hee-Bong Lee Inpyo Choi

PLoS Pathog 2013 3;9(10):e1003646. Epub 2013 Oct 3.

Immunotherapy Research Center, Korea Research Institute of Bioscience and Biotechnology, Yuseong-gu, Daejeon, Republic of Korea ; Department of Functional Genomics, University of Science and Technology, Yuseong-gu, Daejeon, Republic of Korea.

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May 2014

TRAIL negatively regulates VEGF-induced angiogenesis via caspase-8-mediated enzymatic and non-enzymatic functions.

Authors:
Hee-Jun Na Jong-Yun Hwang Kwang-Soon Lee Yoon Kyung Choi Jongseon Choe Ji-Yoon Kim Hyo-Eun Moon Kyu-Won Kim Gou Young Koh Hansoo Lee Dooil Jeoung Moo-Ho Won Kwon-Soo Ha Young-Guen Kwon Young-Myeong Kim

Angiogenesis 2014 Jan 5;17(1):179-94. Epub 2013 Oct 5.

Vascular Homeostasis Laboratory and Department of Molecular and Cellular Biochemistry, School of Medicine, Kangwon National University, Chuncheon, Gangwon-do, 200-701, Korea.

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January 2014

Endothelial progenitor cells from human dental pulp-derived iPS cells as a therapeutic target for ischemic vascular diseases.

Authors:
Chae Hwa Yoo Hee-Jun Na Dong-Seol Lee Soon Chul Heo Yuri An Junghwa Cha Chulhee Choi Jae Ho Kim Joo-Cheol Park Yee Sook Cho

Biomaterials 2013 Nov 26;34(33):8149-60. Epub 2013 Jul 26.

Stem Cells Research Center, KRIBB, Daejeon, Republic of Korea.

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November 2013

TXNIP maintains the hematopoietic cell pool by switching the function of p53 under oxidative stress.

Authors:
Haiyoung Jung Mi Jeong Kim Dong Oh Kim Won Sam Kim Sung-Jin Yoon Young-Jun Park Suk Ran Yoon Tae-Don Kim Hyun-Woo Suh Sohyun Yun Jeong-Ki Min Hee Gu Lee Young Ho Lee Hee-Jun Na Dong Chul Lee Hyoung-Chin Kim Inpyo Choi

Cell Metab 2013 Jul;18(1):75-85

Immunotherapy Research Center, Korea Research Institute of Bioscience and Biotechnology, Yuseong-gu, Daejeon 305-806, Republic of Korea.

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July 2013

Inhibition of MKK7-JNK by the TOR signaling pathway regulator-like protein contributes to resistance of HCC cells to TRAIL-induced apoptosis.

Authors:
In Sung Song Soo Young Jun Hee-Jun Na Hyun-Taek Kim So Young Jung Ga Hee Ha Young-Ho Park Liang Zhe Long Dae-Yeul Yu Jin-Man Kim Joo Heon Kim Jeong-Heon Ko Cheol-Hee Kim Nam-Soon Kim

Gastroenterology 2012 Nov 27;143(5):1341-1351. Epub 2012 Jul 27.

Medical Genomics Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, South Korea; Department of Functional Genomics, University of Science and Technology, Daejeon, South Korea. Electronic address:

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November 2012

Autophagy promotes intracellular degradation of type I collagen induced by transforming growth factor (TGF)-β1.

Authors:
Sung Il Kim Hee-Jun Na Yan Ding Zhibo Wang Seon Jin Lee Mary E Choi

J Biol Chem 2012 Apr 20;287(15):11677-88. Epub 2012 Feb 20.

Renal Division, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.

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April 2012

TGF-{beta}1 protects against mesangial cell apoptosis via induction of autophagy.

Authors:
Yan Ding Jin Kuk Kim Sung Il Kim Hee-Jun Na Soo Young Jun Seon Jin Lee Mary E Choi

J Biol Chem 2010 Nov 28;285(48):37909-19. Epub 2010 Sep 28.

Renal Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.

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November 2010

Transforming growth factor-beta (TGF-beta1) activates TAK1 via TAB1-mediated autophosphorylation, independent of TGF-beta receptor kinase activity in mesangial cells.

Authors:
Sung Il Kim Joon Hyeok Kwak Hee-Jun Na Jin Kuk Kim Yan Ding Mary E Choi

J Biol Chem 2009 Aug 25;284(33):22285-96. Epub 2009 Jun 25.

Renal Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.

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August 2009

The non-provitamin A carotenoid, lutein, inhibits NF-kappaB-dependent gene expression through redox-based regulation of the phosphatidylinositol 3-kinase/PTEN/Akt and NF-kappaB-inducing kinase pathways: role of H(2)O(2) in NF-kappaB activation.

Authors:
Ji-Hee Kim Hee-Jun Na Chun-Ki Kim Ji-Yoon Kim Kwon-Soo Ha Hansoo Lee Hun-Taeg Chung Ho Jeong Kwon Young-Guen Kwon Young-Myeong Kim

Free Radic Biol Med 2008 Sep 27;45(6):885-96. Epub 2008 Jun 27.

Vascular System Research Center and Department of Molecular and Cellular Biochemistry, School of Medicine, Kangwon National University, Chunchon, Kangwon-do 200-701, Korea.

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September 2008

Detection and measurement for the modification and inactivation of caspase by nitrosative stress in vitro and in vivo.

Authors:
Hee-Jun Na Hun-Taeg Chung Kwon-Soo Ha Hansoo Lee Young-Guen Kwon Timothy R Billiar Young-Myeong Kim

Methods Enzymol 2008 ;441:317-27

Vascular System Research Center, Kangwon National University, Chunchon, Korea.

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August 2008

CT20126, a novel immunosuppressant, prevents collagen-induced arthritis through the down-regulation of inflammatory gene expression by inhibiting NF-kappaB activation.

Authors:
Seon-Jin Lee Woo-Dong Nam Hee-Jun Na Young-Lai Cho Kwon-Soo Ha Jong-Yun Hwang Hansoo Lee Soon-Ok Kim Young-Guen Kwon Young-Myeong Kim

Biochem Pharmacol 2008 Jul 18;76(1):79-90. Epub 2008 Apr 18.

Department of Molecular and Cellular Biochemistry and Vascular System Research Center, School of Medicine, Kangwon National University, Chunchon, Kangwon-Do 200-701, Republic of Korea.

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July 2008

4-O-methylgallic acid down-regulates endothelial adhesion molecule expression by inhibiting NF-kappaB-DNA-binding activity.

Authors:
Gwangsoo Lee Hee-Jun Na Seung Namkoong Ho Jeong Kwon Sanghwa Han Kwon-Soo Ha Young-Guen Kwon Hansoo Lee Young-Myeong Kim

Eur J Pharmacol 2006 Dec 8;551(1-3):143-51. Epub 2006 Sep 8.

Vascular System Research Center, School of Medicine, Kangwon National University, Chunchon, 200-701, Republic of Korea.

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December 2006

4-O-Methylgallic acid suppresses inflammation-associated gene expression by inhibition of redox-based NF-kappaB activation.

Authors:
Hee-Jun Na Gwangsoo Lee Heung-Young Oh Ki-Suk Jeon Ho-Jeong Kwon Kwon-Soo Ha Hansoo Lee Young-Guen Kwon Young-Myeong Kim

Int Immunopharmacol 2006 Oct 7;6(10):1597-608. Epub 2006 Jul 7.

Vascular System Research Center and Department of Molecular and Cellular Biochemistry, School of Medicine, Kangwon National University, Chunchon 200-701, Republic of Korea.

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October 2006

beta-Carotene inhibits inflammatory gene expression in lipopolysaccharide-stimulated macrophages by suppressing redox-based NF-kappaB activation.

Authors:
Se-Kyung Bai Seon-Jin Lee Hee-Jun Na Kwon-Soo Ha Jeong-A Han Hansoo Lee Young-Guen Kwon Cha-Kwon Chung Young-Myeong Kim

Exp Mol Med 2005 Aug;37(4):323-34

Vascular System Research Center, Department of Molecular and Cellular Biochemistry, School of Medicine, Kangwon National University, Chunchon, Kangwon-do 200-701, Korea.

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August 2005

Antiangiogenic activity of 4-O-methylgallic acid from Canavalia gladiata, a dietary legume.

Authors:
Ki Suk Jeon Hee-Jun Na Young-Myeong Kim Ho Jeong Kwon

Biochem Biophys Res Commun 2005 May;330(4):1268-74

Chemical Genomics National Research Laboratory, Department of Bioscience and Biotechnology, Institute of Bioscience, Sejong University, Kwangjin-Gu, Seoul 143-747, Republic of Korea.

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May 2005

Inhibition of farnesyltransferase prevents collagen-induced arthritis by down-regulation of inflammatory gene expression through suppression of p21(ras)-dependent NF-kappaB activation.

Authors:
Hee-Jun Na Seon-Jin Lee Yun-Chul Kang Young-Lai Cho Woo-Dong Nam Peter K M Kim Kwon-Soo Ha Hun-Taeg Chung Hansoo Lee Young-Guen Kwon Jong Sung Koh Young-Myeong Kim

J Immunol 2004 Jul;173(2):1276-83

Vascular System Research Center and Department of Molecular and Cellular Biochemistry, School of Medicine, Kangwon National University, Chunchon, Kangwon-do, Korea.

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July 2004

Astaxanthin inhibits nitric oxide production and inflammatory gene expression by suppressing I(kappa)B kinase-dependent NF-kappaB activation.

Authors:
Seon-Jin Lee Se-Kyung Bai Kwang-Soon Lee Seung Namkoong Hee-Jun Na Kwon-Soo Ha Jeong-A Han Sung-Vin Yim Kwang Chang Young-Guen Kwon Sung Ki Lee Young-Myeong Kim

Mol Cells 2003 Aug;16(1):97-105

Vascular System Research Center and Department of Molecular and Cellular Biochemistry, Kangwon National University Biology, Chunchon 200-701, Korea.

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August 2003

IL-4 inhibits cell cycle progression of human umbilical vein endothelial cells by affecting p53, p21(Waf1), cyclin D1, and cyclin E expression.

Authors:
Jinkoo Kim In Su Cheon Yu-Jin Won Hee Jun Na Young-Myeong Kim Jongseon Choe

Mol Cells 2003 Aug;16(1):92-6

Vascular System Research Center, Kangwon National University, Chunchon 200-701, Korea.

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August 2003

Hematein inhibits atherosclerosis by inhibition of reactive oxygen generation and NF-kappaB-dependent inflammatory mediators in hyperlipidemic mice.

Authors:
Jae-Hoon Choi Tae-Sook Jeong Dae-Yong Kim Young-Myeong Kim Hee-Jun Na Ki-Hwan Nam Sae-Bom Lee Hyoung-Chin Kim Sei Ryang Oh Yang-Kyu Choi Song-Hae Bok Goo Taeg Oh

J Cardiovasc Pharmacol 2003 Aug;42(2):287-95

Department of Veterinary Pathology, College of Veterinary Medicine and Agricultural Biotechnology, Seoul National University, Suwon, Korea.

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August 2003

Nitric oxide (NO) pretreatment increases cytokine-induced NO production in cultured rat hepatocytes by suppressing GTP cyclohydrolase I feedback inhibitory protein level and promoting inducible NO synthase dimerization.

Authors:
Joon-Hong Park Hee-Jun Na Young-Guen Kwon Kwon-Soo Ha Seon-Jin Lee Chun-Ki Kim Kwang-Soon Lee Toshie Yoneyama Kazuyuki Hatakeyama Peter K M Kim Timothy R Billiar Young-Myeong Kim

J Biol Chem 2002 Dec 30;277(49):47073-9. Epub 2002 Sep 30.

Vascular System Research Center and Department of Molecular and Cellular Biochemistry, Kangwon National University, School of Medicine, Chunchon, Kangwon-do 200-701, Korea.

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December 2002