Publications by authors named "Hee Sun Byun"

34Publications

3-O-acetylrubianol C (3AR-C) induces RIPK1-dependent programmed cell death by selective inhibition of IKKβ.

FASEB J 2020 03 6;34(3):4369-4383. Epub 2020 Feb 6.

Department of Pharmacology and Department of Medical Science, College of Medicine, Chungnam National University, Daejeon, Republic of Korea.

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March 2020

Accelerated degradation of cFLIP and sensitization of the TRAIL DISC-mediated apoptotic cascade by pinoresinol, a lignan isolated from Rubia philippinensis.

Sci Rep 2019 09 18;9(1):13505. Epub 2019 Sep 18.

Department of Pharmacology and Department of Medical Science, College of Medicine, Chungnam National University, 266 Munhwa-ro, Daejeon, 35015, Republic of Korea.

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September 2019

Oridonin enhances TRAIL-induced apoptosis through GALNT14-mediated DR5 glycosylation.

Biochimie 2019 Oct 20;165:108-114. Epub 2019 Jul 20.

Department of Immunology, School of Medicine, Keimyung University, 1095 Dalgubeoldaero, Dalseo-Gu, Daegu, 42601, South Korea. Electronic address:

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October 2019

C-27-carboxylated oleanane triterpenoids up-regulate TRAIL DISC assembly via p38 MAPK and CHOP-mediated DR5 expression in human glioblastoma cells.

Biochem Pharmacol 2018 12 22;158:243-260. Epub 2018 Oct 22.

Department of Pharmacology, College of Medicine, Chungnam National University, 266 Munhwa-ro, Daejeon 35015, Republic of Korea. Electronic address:

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December 2018

The anti-inflammatory role of extranuclear apurinic/apyrimidinic endonuclease 1/redox effector factor-1 in reactive astrocytes.

Mol Brain 2016 12 16;9(1):99. Epub 2016 Dec 16.

Department of Physiology and Department of Medical Science, School of Medicine, Chungnam National University, 266 Munhwa-Ro, Jung-gu, Daejeon, 30501, Republic of Korea.

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December 2016

IinQ attenuates systemic inflammatory responses via selectively impairing the Myddosome complex formation upon TLR4 ligation.

Biochem Pharmacol 2016 Dec 21;121:52-66. Epub 2016 Sep 21.

Department of Pharmacology, College of Medicine, Chungnam National University, 266 Munhwa-ro, Daejeon 35015, Republic of Korea; Department of Medical Science, College of Medicine, Chungnam National University, 266 Munhwa-ro, Daejeon 35015, Republic of Korea. Electronic address:

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December 2016

Post-translational control of NF-κB signaling by ubiquitination.

Arch Pharm Res 2016 Aug 10;39(8):1075-84. Epub 2016 Jun 10.

Research Institute for Medical Science, College of Medicine, Chungnam National University, Daejeon, 35015, Republic of Korea.

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August 2016

Terminalia Chebula provides protection against dual modes of necroptotic and apoptotic cell death upon death receptor ligation.

Sci Rep 2016 04 27;6:25094. Epub 2016 Apr 27.

Department of Pharmacology, Research Institute for Medical Science, College of Medicine, Chungnam National University, Daejeon 301-131, Republic of Korea.

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April 2016

Casein kinase II regulates N-methyl-D-aspartate receptor activity in spinal cords and pain hypersensitivity induced by nerve injury.

J Pharmacol Exp Ther 2014 Aug 4;350(2):301-12. Epub 2014 Jun 4.

Center for Neuroscience and Pain Research, Department of Anesthesiology and Perioperative Medicine, University of Texas MD Anderson Cancer Center, Houston, Texas

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August 2014

Brazilin selectively disrupts proximal IL-1 receptor signaling complex formation by targeting an IKK-upstream signaling components.

Biochem Pharmacol 2014 Jun 13;89(4):515-25. Epub 2014 Apr 13.

Department of Pharmacology, Daejeon Regional Cancer Center, College of Medicine, Chungnam National University, 6 Munhwa-dong, Jung-gu, Daejeon 301-747, Republic of Korea. Electronic address:

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June 2014

Nerve injury increases GluA2-lacking AMPA receptor prevalence in spinal cords: functional significance and signaling mechanisms.

J Pharmacol Exp Ther 2013 Dec 12;347(3):765-72. Epub 2013 Sep 12.

Center for Neuroscience and Pain Research, Department of Anesthesiology and Perioperative Medicine, The University of Texas M.D. Anderson Cancer Center, Houston, Texas (S.-R.C., H.-Y.Z., H.S.B., H.-L.P.); Graduate Program in Neuroscience, The University of Texas Graduate School of Biomedical Sciences, Houston, Texas (H.-L.P.).

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December 2013

Intron-derived aberrant splicing of A20 transcript in rheumatoid arthritis.

Rheumatology (Oxford) 2013 Mar 12;52(3):427-37. Epub 2012 Nov 12.

Department of Pharmacology, College of Medicine, Chungnam National University, 6 Munhwa-dong, Jung-gu, Daejeon, Korea.

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March 2013

N-methyl-D-aspartate receptor- and calpain-mediated proteolytic cleavage of K+-Cl- cotransporter-2 impairs spinal chloride homeostasis in neuropathic pain.

J Biol Chem 2012 Sep 1;287(40):33853-64. Epub 2012 Aug 1.

Center for Neuroscience and Pain Research, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.

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September 2012

NKCC1 upregulation disrupts chloride homeostasis in the hypothalamus and increases neuronal activity-sympathetic drive in hypertension.

J Neurosci 2012 Jun;32(25):8560-8

Center for Neuroscience and Pain Research, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.

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June 2012

Cucurbitacin induces autophagy through mitochondrial ROS production which counteracts to limit caspase-dependent apoptosis.

Autophagy 2012 Apr 1;8(4):559-76. Epub 2012 Apr 1.

Department of Pharmacology, Research Institute for Medical Science, Infection Signaling Network Research Center, Daejeon Regional Cancer Center, Daejeon, Republic of Korea.

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April 2012

Diabetic neuropathy enhances voltage-activated Ca2+ channel activity and its control by M4 muscarinic receptors in primary sensory neurons.

J Neurochem 2011 Nov 21;119(3):594-603. Epub 2011 Sep 21.

Department of Anesthesiology and Perioperative Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

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November 2011

Apoptosis signal-regulating kinase1 is inducible by protein kinase Cδ and contributes to phorbol ester-mediated G1 phase arrest through persistent JNK activation.

Cell Biochem Biophys 2011 Sep;61(1):199-207

Department of Pharmacology, Research Institute for Medical Science, Infection Signaling Network Research Center, Daejeon Regional Cancer Center, College of Medicine, Chungnam National University, Daejeon 301-131, Republic of Korea.

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September 2011

Reduction in voltage-gated K+ channel activity in primary sensory neurons in painful diabetic neuropathy: role of brain-derived neurotrophic factor.

J Neurochem 2010 Sep 24;114(5):1460-75. Epub 2010 Jun 24.

Department of Anesthesiology and Perioperative Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.

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September 2010

Heat shock protein 70-mediated sensitization of cells to apoptosis by Carboxyl-Terminal Modulator Protein.

BMC Cell Biol 2009 Jul 15;10:53. Epub 2009 Jul 15.

Department of Pharmacology, Daejeon Regional Cancer Center, Cancer Research Institute, Research Institute for Medical Sciences, College of Medicine, Chungnam National University, Taejeon, 301-131, Korea.

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July 2009

Protein kinase SGK1 enhances MEK/ERK complex formation through the phosphorylation of ERK2: implication for the positive regulatory role of SGK1 on the ERK function during liver regeneration.

J Hepatol 2009 Jul 16;51(1):67-76. Epub 2009 Apr 16.

Department of Pharmacology, Research Institute for Medical Science, Infection Signaling Network Research Center, Daejeon Regional Cancer Center, College of Medicine, Chungnam National University, 6 Munhwa-dong, Jung-gu, Daejeon 301-131, Republic of Korea.

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July 2009

Regulation of OPA1-mediated mitochondrial fusion by leucine zipper/EF-hand-containing transmembrane protein-1 plays a role in apoptosis.

Cell Signal 2009 May 9;21(5):767-77. Epub 2009 Jan 9.

Department of Pharmacology, Daejeon Regional Cancer Center, Cancer Research Institute, Research Institute for Medical Sciences, College of Medicine, Chungnam National University, Taejeon, 301-131, Republic of Korea.

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May 2009

Activation Mechanism of Protein Kinase B by DNA-dependent Protein Kinase Involved in the DNA Repair System.

Toxicol Res 2008 Sep 1;24(3):175-182. Epub 2008 Sep 1.

13Department of Pharmacology, Cell Signaling Laboratory, Research Center for Transgenic Cloned Pigs, Daejeon Regional Cancer Center, Cancer Research Institute, Research Institute for Medical Sciences, Korea.

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September 2008

Long-term Activation of c-Jun N-terminal Kinase through Receptor Interacting Protein is Associated with DNA Damage-induced Cell Death.

Korean J Physiol Pharmacol 2008 Aug 31;12(4):185-91. Epub 2008 Aug 31.

Department of Pharmacology, Research Institute for Medical Sciences, College of Medicine, Chungnam National University, Daejeon 301-131, Korea.

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August 2008

Prevention of TNF-induced necrotic cell death by rottlerin through a Nox1 NADPH oxidase.

Exp Mol Med 2008 Apr;40(2):186-95

Department of Pharmacology, Research Institute for Medical Science, Infection Signaling Network Research Center, College of Medicine, Chungnam National University, Daejeon 301-131, Korea.

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April 2008

Cyclo(dehydrohistidyl-l-tryptophyl) inhibits nitric oxide production by preventing the dimerization of inducible nitric oxide synthase.

Biochem Pharmacol 2008 Feb 24;75(4):923-30. Epub 2007 Oct 24.

Functional Metabolites Research Center, Korea Research Institute of Bioscience and Biotechnology, Yusong, Daejeon 305-806, Republic of Korea.

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February 2008

Regulation of 3-phosphoinositide-dependent protein kinase-1 (PDK1) by Src involves tyrosine phosphorylation of PDK1 and Src homology 2 domain binding.

J Biol Chem 2008 Jan 16;283(3):1480-91. Epub 2007 Nov 16.

Department of Pharmacology, Daejeon Regional Cancer Center, Cancer Research Institute, Chungnam National University, 6 Munhwa-Dong, Jung-Gu, Taejeon 301-131, South Korea.

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January 2008

Sustained activation of protein kinase C downregulates nuclear factor-kappaB signaling by dissociation of IKK-gamma and Hsp90 complex in human colonic epithelial cells.

Carcinogenesis 2007 Jan 14;28(1):71-80. Epub 2006 Jun 14.

Department of Pharmacology, Cancer Research Institute, College of Medicine, Chungnam National University, 6 Munhwa-dong, Jung-gu, Daejeon 301-131, Korea.

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January 2007

Thioredoxin overexpression in HT-1080 cells induced cellular senescence and sensitization to gamma radiation.

FEBS Lett 2005 Aug;579(19):4055-62

Department of Radiation Biology, Environmental Radiation Research Group, Korea Atomic Energy Research Institute, P.O. Box 105, Yuseong, Daejeon 305-600, Republic of Korea.

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August 2005

GAD 67KD antisense in colon cancer cells inhibits cell growth and sensitizes to butyrate and pH reduction and H2O2 and gamma-radiation.

Arch Biochem Biophys 2004 Oct;430(2):229-36

Department of Radiation Biology, Environmental Radiation Research Group, Korea Atomic Energy Research Institute, PO Box 105, Yusong, Taejon 305-600, Republic of Korea.

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October 2004