Publications by authors named "Hedwig E Deubzer"

42Publications

Sinusoidal Obstruction Syndrome Following Myeloablative Therapy and Tranexamic Acid Treatment for Hemorrhage in Two Patients with Neuroblastoma.

Children (Basel) 2020 Oct 28;7(11). Epub 2020 Oct 28.

Department of Pediatric Hematology and Oncology, Charité-Universitätsmedizin Berlin, 13353 Berlin, Germany.

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October 2020

Multiplexed Quantification of Four Neuroblastoma DNA Targets in a Single Droplet Digital PCR Reaction.

J Mol Diagn 2020 Aug 26. Epub 2020 Aug 26.

Department of Pediatric Hematology and Oncology, Charité-Universitätsmedizin Berlin, Berlin, Germany; Neuroblastoma Research Group, Experimental and Clinical Research Center, Berlin, Germany.

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August 2020

Central memory phenotype drives success of checkpoint inhibition in combination with CAR T cells.

Mol Carcinog 2020 07 25;59(7):724-735. Epub 2020 Apr 25.

Department of Pediatric Oncology and Hematology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt - Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.

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July 2020

Tumor-Derived Extracellular Vesicles Impair CD171-Specific CD4 CAR T Cell Efficacy.

Front Immunol 2020 31;11:531. Epub 2020 Mar 31.

Department of Pediatric Oncology and Hematology, Berlin Institute of Health, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.

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March 2020

Transmission of chromosomally integrated human herpes virus-6A via haploidentical stem cell transplantation poses a risk for virus reactivation and associated complications.

Bone Marrow Transplant 2020 01 15;55(1):260-264. Epub 2019 Apr 15.

Department of Pediatric Hematology and Oncology, Charité - Universitätsmedizin Berlin, Augustenburger Platz 1, 13353, Berlin, Germany.

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January 2020

Synergistic activity of BET inhibitor MK-8628 and PLK inhibitor Volasertib in preclinical models of medulloblastoma.

Cancer Lett 2019 03 4;445:24-33. Epub 2019 Jan 4.

Department of Pediatric Oncology/Hematology, Charité-Universitätsmedizin Berlin, Germany; German Consortium for Translational Cancer Research (DKTK), Berlin, Germany; Berlin Institute of Health (BIH), Berlin, Germany. Electronic address:

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March 2019

Reactivating TP53 signaling by the novel MDM2 inhibitor DS-3032b as a therapeutic option for high-risk neuroblastoma.

Oncotarget 2018 Jan 18;9(2):2304-2319. Epub 2017 Dec 18.

Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Pediatric Hematology/Oncology/Stem Cell Transplantation, Berlin, Germany.

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January 2018

Using droplet digital PCR to analyze and copy number in plasma from patients with neuroblastoma.

Oncotarget 2017 Oct 7;8(49):85234-85251. Epub 2017 Jul 7.

Department of Pediatric Hematology, Oncology and Stem Cell Transplantation, Charité-Universitätsmedizin Berlin, Berlin, Germany.

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October 2017

Neuroblastoma cells depend on HDAC11 for mitotic cell cycle progression and survival.

Cell Death Dis 2017 03 2;8(3):e2635. Epub 2017 Mar 2.

Department of Pediatric Hematology, Oncology and SCT, Charité-Universitätsmedizin Berlin, Campus Virchow-Klinikum, Augustenburger Platz 1, Berlin 13353, Germany.

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March 2017

Minichromosome Maintenance Complex Is a Critical Node in the miR-183 Signaling Network of MYCN-Amplified Neuroblastoma Cells.

J Proteome Res 2016 07 9;15(7):2178-86. Epub 2016 Jun 9.

Department of Pediatric Hematology/Oncology/Stem Cell Transplantation Charité - Universitätsmedizin Berlin , Campus Virchow-Klinikum, Augustenburger Platz 1, 13353 Berlin, Germany.

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July 2016

GRHL1 acts as tumor suppressor in neuroblastoma and is negatively regulated by MYCN and HDAC3.

Cancer Res 2014 May 13;74(9):2604-16. Epub 2014 Jan 13.

Authors' Affiliations: Clinical Cooperation Unit Pediatric Oncology; Departments of Biostatistics and Tumor Genetics; Clinical Cooperation Unit Neuropathology; Division of Epigenomics and Cancer Risk Factors, German Cancer Research Center (DKFZ); Departments of Neuropathology and Pediatric Hematology and Oncology, University of Heidelberg, Heidelberg; Transcriptome Analysis Laboratory, University of Goettingen, Goettingen; St. Lukas Klinik Solingen, Solingen; Department of Pediatric Hematology and Oncology; and Center for Molecular Medicine Cologne, University of Cologne, Cologne, Germany.

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May 2014

Small molecule inhibitors of aurora-a induce proteasomal degradation of N-myc in childhood neuroblastoma.

Cancer Cell 2013 Jul 20;24(1):75-89. Epub 2013 Jun 20.

Comprehensive Cancer Center Mainfranken and Theodor Boveri Institute, Biocenter, University of Würzburg, Am Hubland, 97074 Würzburg, Germany.

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July 2013

HD-MB03 is a novel Group 3 medulloblastoma model demonstrating sensitivity to histone deacetylase inhibitor treatment.

J Neurooncol 2012 Dec 6;110(3):335-48. Epub 2012 Oct 6.

Clinical Cooperation Unit Pediatric Oncology (G340), German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany.

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December 2012

HDAC11 is a novel drug target in carcinomas.

Int J Cancer 2013 May 25;132(9):2200-8. Epub 2012 Oct 25.

Clinical Cooperation Unit Pediatric Oncology (G340), German Cancer Research Center (DKFZ), Heidelberg, Germany.

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May 2013

Parvovirus H1 selectively induces cytotoxic effects on human neuroblastoma cells.

Int J Cancer 2010 Sep;127(5):1230-9

Program Infection and Cancer, Department F010 and INSERM U701, German Cancer Research Center, Im Neuenheimer Feld 242, D-69120 Heidelberg, Germany.

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September 2010

Targeting of HDAC8 and investigational inhibitors in neuroblastoma.

Expert Opin Investig Drugs 2009 Nov;18(11):1605-17

German Cancer Research Center, CCU Pediatric Oncology, INF 280, D-69120 Heidelberg, Germany.

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November 2009

HDAC family: What are the cancer relevant targets?

Cancer Lett 2009 May 27;277(1):8-21. Epub 2008 Sep 27.

CCU Pediatric Oncology (G340), German Cancer Research Center, Im Neuenheimer Feld 280, Heidelberg, Germany.

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May 2009

Transcription factor AP2alpha (TFAP2a) regulates differentiation and proliferation of neuroblastoma cells.

Cancer Lett 2008 Nov 11;271(1):56-63. Epub 2008 Jul 11.

Department of Pediatric Oncology and Hematology, University Children's Hospital Essen, Essen, Germany.

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November 2008

Serotype-specific pneumococcal antibodies in breast milk of Gambian women immunized with a pneumococcal polysaccharide vaccine during pregnancy.

Pediatr Infect Dis J 2004 Nov;23(11):1023-9

Imperial College, School of Science, Technology and Medicine, Department of Immunology, Chelsea and Westminster Hospital, London, United Kingdom.

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November 2004

Colostrum obtained from women vaccinated with pneumococcal vaccine during pregnancy inhibits epithelial adhesion of Streptococcus pneumoniae.

J Infect Dis 2004 Nov 7;190(10):1758-61. Epub 2004 Oct 7.

Imperial College, Faculty of Medicine, Department of Immunology, Chelsea and Westminster Hospital, London, United Kingdom.

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November 2004