Dr Hector Peinado, PhD - CNIO - Spanish National Cancer Research Center

Dr Hector Peinado

PhD

CNIO - Spanish National Cancer Research Center

Madrid, Madrid | Spain

Dr Hector Peinado, PhD - CNIO - Spanish National Cancer Research Center

Dr Hector Peinado

PhD

Introduction

Primary Affiliation: CNIO - Spanish National Cancer Research Center - Madrid, Madrid , Spain

Publications

40Publications

2238Reads

2Profile Views

5033PubMed Central Citations

Mast cells and exosomes in hyperoxia-induced neonatal lung disease.

Am J Physiol Lung Cell Mol Physiol 2016 06 29;310(11):L1218-32. Epub 2016 Apr 29.

Department of Physiology and Biophysics, Weill Cornell Medicine, New York, New York;

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http://dx.doi.org/10.1152/ajplung.00299.2015DOI Listing
June 2016
11 Reads
3 Citations
4.080 Impact Factor

Characterization of Induced Pluripotent Stem Cell Microvesicle Genesis, Morphology and Pluripotent Content.

Sci Rep 2016 Jan 22;6:19743. Epub 2016 Jan 22.

Department of Biological Sciences, City University of New York, Lehman College, 250 Bedford Park Boulevard West, Bronx, NY 10468.

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http://dx.doi.org/10.1038/srep19743DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4726265PMC
January 2016
56 Reads
7 Citations
5.080 Impact Factor

Gasdermin-B promotes invasion and metastasis in breast cancer cells.

PLoS One 2014 27;9(3):e90099. Epub 2014 Mar 27.

Departamento de Bioquímica, Universidad Autónoma de Madrid (UAM), Instituto de Investigaciones Biomédicas "Alberto Sols" (CSIC-UAM), IdiPAZ, Madrid, Spain; Fundación MD Anderson Internacional, Madrid, Spain.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0090099PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3967990PMC
December 2015
98 Reads
9 Citations
3.234 Impact Factor

FunRich proteomics software analysis, let the fun begin!

Proteomics 2015 Aug;15(15):2555-6

Children's Cancer and Blood Foundation Laboratories, Department of Pediatrics, Weill Cornell Medical College, New York, NY, USA.

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http://dx.doi.org/10.1002/pmic.201500260DOI Listing
August 2015
55 Reads
8 Citations
3.810 Impact Factor

Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver.

Nat Cell Biol 2015 Jun 18;17(6):816-26. Epub 2015 May 18.

1] Children's Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medical College, New York, New York 10021, USA [2] Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA.

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http://dx.doi.org/10.1038/ncb3169DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5769922PMC
June 2015
162 Reads
318 Citations
19.680 Impact Factor

Loss of Snail2 favors skin tumor progression by promoting the recruitment of myeloid progenitors.

Carcinogenesis 2015 May 16;36(5):585-97. Epub 2015 Mar 16.

Departamento de Bioquímica, Universidad Autónoma de Madrid: Instituto de Investigaciones Biomédicas "Alberto Sols" CSIC-UAM; IdiPAZ, Madrid 28029, Spain,

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http://dx.doi.org/10.1093/carcin/bgv021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4417341PMC
May 2015
23 Reads
2 Citations
5.334 Impact Factor

Id1 suppresses anti-tumour immune responses and promotes tumour progression by impairing myeloid cell maturation.

Nat Commun 2015 Apr 29;6:6840. Epub 2015 Apr 29.

1] Children's Cancer and Blood Foundation Laboratories and Departments of Pediatrics and Cell and Developmental Biology, Weill Cornell Medical College, 413 East 69th Street, New York City, New York 10021, USA [2] Department of Pediatrics, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York City, New York 10065, USA.

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http://dx.doi.org/10.1038/ncomms7840DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4423225PMC
April 2015
68 Reads
12 Citations
10.742 Impact Factor

The new deal: a potential role for secreted vesicles in innate immunity and tumor progression.

Front Immunol 2015 24;6:66. Epub 2015 Feb 24.

Children's Cancer and Blood Foundation Laboratories, Department of Pediatrics, Weill Cornell Medical College , New York, NY , USA ; Microenvironment and Metastasis Laboratory, Department of Molecular Oncology, Spanish National Cancer Research Centre (CNIO) , Madrid , Spain.

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http://dx.doi.org/10.3389/fimmu.2015.00066DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4338782PMC
March 2015
6 Reads
22 Citations

Double-stranded DNA in exosomes: a novel biomarker in cancer detection.

Cell Res 2014 Jun 8;24(6):766-9. Epub 2014 Apr 8.

Children's Cancer and Blood Foundation Laboratories, Departments of Pediatrics, Cell and Developmental Biology, Weill Cornell Medical College, New York, NY 10021, USA.

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http://dx.doi.org/10.1038/cr.2014.44DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4042169PMC
June 2014
170 Reads
196 Citations
12.413 Impact Factor

Macromolecular crowding meets tissue engineering by self-assembly: a paradigm shift in regenerative medicine.

Adv Mater 2014 May 6;26(19):3024-34. Epub 2014 Feb 6.

Network of Excellence for Functional Biomaterials (NFB), National University of Ireland Galway, (NUI Galway), Galway, Ireland.

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http://dx.doi.org/10.1002/adma.201304428DOI Listing
May 2014
31 Reads
12 Citations
17.493 Impact Factor

E47 and Id1 interplay in epithelial-mesenchymal transition.

PLoS One 2013 26;8(3):e59948. Epub 2013 Mar 26.

Departamento de Bioquímica, Facultad de Medicina, Universidad Autónoma de Madrid (UAM), Instituto de Investigaciones Biomédicas Alberto Sols (CSIC-UAM), IdiPAZ, Madrid, Spain.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0059948PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3608585PMC
January 2014
19 Reads
16 Citations
3.234 Impact Factor

The perivascular niche regulates breast tumour dormancy.

Nat Cell Biol 2013 Jul 2;15(7):807-17. Epub 2013 Jun 2.

Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA.

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http://dx.doi.org/10.1038/ncb2767DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3826912PMC
July 2013
134 Reads
201 Citations
19.680 Impact Factor

Mutation of SIMPLE in Charcot-Marie-Tooth 1C alters production of exosomes.

Mol Biol Cell 2013 Jun 10;24(11):1619-37, S1-3. Epub 2013 Apr 10.

Department of Molecular Pharmacology, Albert Einstein College of Medicine, New York, NY 10461, USA.

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http://dx.doi.org/10.1091/mbc.E12-07-0544DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3667717PMC
June 2013
9 Reads
15 Citations
4.470 Impact Factor

Regulation of SNAIL1 and E-cadherin function by DNMT1 in a DNA methylation-independent context.

Nucleic Acids Res 2011 Nov 16;39(21):9194-205. Epub 2011 Aug 16.

Instituto de Investigaciones Biomédicas Alberto Sols, CSIC-UAM, Instituto de Investigación Hospital Universitario La Paz, Madrid, Spain.

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http://dx.doi.org/10.1093/nar/gkr658DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3241660PMC
November 2011
11 Reads
18 Citations
9.112 Impact Factor

Lysyl oxidase-like 2 (LOXL2), a new regulator of cell polarity required for metastatic dissemination of basal-like breast carcinomas.

EMBO Mol Med 2011 Sep 6;3(9):528-44. Epub 2011 Jul 6.

Departamento de Bioquímica, UAM, Instituto de Investigaciones Biomédicas "Alberto Sols", CSIC-UAM, IdiPAZ, Instituto de Investigación Sanitaria La Paz, Madrid, Spain.

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http://dx.doi.org/10.1002/emmm.201100156DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3377095PMC
September 2011
57 Reads
48 Citations
8.665 Impact Factor

The secreted factors responsible for pre-metastatic niche formation: old sayings and new thoughts.

Semin Cancer Biol 2011 Apr 18;21(2):139-46. Epub 2011 Jan 18.

Department of Pediatrics, Weill Cornell Medical College, New York, NY 10021, USA.

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http://dx.doi.org/10.1016/j.semcancer.2011.01.002DOI Listing
April 2011
31 Reads
154 Citations
9.330 Impact Factor

The morphological and molecular features of the epithelial-to-mesenchymal transition.

Nat Protoc 2009 15;4(11):1591-613. Epub 2009 Oct 15.

Departamento de Bioquímica, Universidad Autónoma de Madrid, Instituto de Investigaciones Biomédicas 'Alberto Sols' CSIC-UAM, Madrid, Spain.

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http://dx.doi.org/10.1038/nprot.2009.152DOI Listing
January 2010
36 Reads
65 Citations

PAI-1 and functional blockade of SNAI1 in breast cancer cell migration.

Breast Cancer Res 2008 3;10(6):R100. Epub 2008 Dec 3.

DYNAMIC Team, IBISC FRE 3190 CNRS - Université d'Evry Val d'Essonne, Genopole, Evry 91000, France.

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http://dx.doi.org/10.1186/bcr2203DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2656896PMC
April 2009
85 Reads
10 Citations

Inflammation joins the "niche".

Cancer Cell 2008 Nov;14(5):347-9

Department of Cell and Developmental Biology, Weill Cornell Medical College, New York, NY 10021, USA.

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http://dx.doi.org/10.1016/j.ccr.2008.10.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2951628PMC
November 2008
3 Reads
15 Citations
23.523 Impact Factor

HMGA2 and Smads co-regulate SNAIL1 expression during induction of epithelial-to-mesenchymal transition.

J Biol Chem 2008 Nov 1;283(48):33437-46. Epub 2008 Oct 1.

Ludwig Institute for Cancer Research, Box 595 Biomedical Center, Uppsala University, SE-751 24 Uppsala, Sweden.

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http://dx.doi.org/10.1074/jbc.M802016200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2662269PMC
November 2008
24 Reads
107 Citations
4.573 Impact Factor

Lysyl oxidase-like 2 as a new poor prognosis marker of squamous cell carcinomas.

Cancer Res 2008 Jun;68(12):4541-50

Departamento de Bioquímica, Instituto de Investigaciones Biomédicas "Alberto Sols" Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid, Universidad Autónoma de Madrid, Madrid, Spain.

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http://dx.doi.org/10.1158/0008-5472.CAN-07-6345DOI Listing
June 2008
33 Reads
54 Citations
9.330 Impact Factor

Cutaneous cancer stem cell maintenance is dependent on beta-catenin signalling.

Nature 2008 Apr;452(7187):650-3

Ecole Polytechnique Fédérale de Lausanne/ISREC (Swiss Institute for Experimental Cancer Research) and National Center of Competence in Research Molecular Oncology, Chemin des Boveresses 155, 1066 Epalinges, Switzerland.

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http://www.nature.com/articles/nature06835
Publisher Site
http://dx.doi.org/10.1038/nature06835DOI Listing
April 2008
55 Reads
190 Citations
42.351 Impact Factor

A hypoxic twist in metastasis.

Nat Cell Biol 2008 Mar;10(3):253-4

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http://dx.doi.org/10.1038/ncb0308-253DOI Listing
March 2008
25 Reads
20 Citations
19.680 Impact Factor

Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype?

Nat Rev Cancer 2007 Jun 17;7(6):415-28. Epub 2007 May 17.

Departamento de Bioquímica, Facultad de Medicina, Universidad Autónoma de Madrid (UAM), Instituto de Investigaciones Biomédicas Alberto Sols CSIC-UAM, Arturo Duperier 4, 28029 Madrid, Spain.

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http://dx.doi.org/10.1038/nrc2131DOI Listing
June 2007
5 Reads
999 Citations
37.400 Impact Factor

Mechanisms of endothelial cell protection by blockade of the JAK2 pathway.

Am J Physiol Cell Physiol 2007 Mar 11;292(3):C1123-31. Epub 2006 Oct 11.

Laboratorio de Nefrología-Hipertensión, Fundación Jiménez Díaz, Universidad Autónoma, Avda. Reyes Católicos 2, 28040 Madrid, Spain.

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http://dx.doi.org/10.1152/ajpcell.00548.2005DOI Listing
March 2007
29 Reads
4 Citations
3.780 Impact Factor

Potentiation of tumor formation by topical administration of 15-deoxy-delta12,14-prostaglandin J2 in a model of skin carcinogenesis.

Carcinogenesis 2006 Feb 19;27(2):328-36. Epub 2005 Aug 19.

Instituto de Bioquímica, CSIC-UCM, 28040 Madrid, Spain.

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http://dx.doi.org/10.1093/carcin/bgi213DOI Listing
February 2006
43 Reads
7 Citations
5.334 Impact Factor

Switching on-off Snail: LOXL2 versus GSK3beta.

Cell Cycle 2005 Dec 5;4(12):1749-52. Epub 2005 Dec 5.

Departamento de Bioquímica, Universidad Autónoma de Madrid, Instituto de Investigaciones Biomódicas Alberto Sols, Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid, Madrid, Spain.

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http://dx.doi.org/10.4161/cc.4.12.2224DOI Listing
December 2005
88 Reads
23 Citations

A molecular role for lysyl oxidase-like 2 enzyme in snail regulation and tumor progression.

EMBO J 2005 Oct 18;24(19):3446-58. Epub 2005 Aug 18.

Departamento de Bioquímica, Instituto de Investigaciones Biomédicas Alberto Sols, Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid, Arturo Duperier, Madrid, Spain.

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http://dx.doi.org/10.1038/sj.emboj.7600781DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1276164PMC
October 2005
26 Reads
115 Citations
10.434 Impact Factor

Direct metabolic regulation of beta-catenin activity by the p85alpha regulatory subunit of phosphoinositide 3-OH kinase.

Exp Cell Res 2005 May;305(2):409-17

Centro Nacional de Investigaciones Oncológicas, Instituto de Salud Carlos III, Melchor-Fernández Almagro 3, 28029 Madrid, Spain.

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http://dx.doi.org/10.1016/j.yexcr.2005.01.009DOI Listing
May 2005
19 Reads
3.250 Impact Factor

Transcriptional regulation of cadherins during development and carcinogenesis.

Int J Dev Biol 2004 ;48(5-6):365-75

Department of Biochemistry, Faculty of Medicine, Universidad Autónoma de Madrid, Instituto de Investigaciones Biomédicas Alberto Sols, CSIC-UAM, 28029 Madrid. Spain.

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http://dx.doi.org/10.1387/ijdb.041794hpDOI Listing
February 2005
157 Reads
142 Citations
1.903 Impact Factor

A mouse skin multistage carcinogenesis model reflects the aberrant DNA methylation patterns of human tumors.

Cancer Res 2004 Aug;64(16):5527-34

Cancer Epigenetics Laboratory, Molecular Pathology Program, Spanish National Cancer Centre, Madrid, Spain.

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http://dx.doi.org/10.1158/0008-5472.CAN-03-4061DOI Listing
August 2004
19 Reads
46 Citations
9.330 Impact Factor

Snail and E47 repressors of E-cadherin induce distinct invasive and angiogenic properties in vivo.

J Cell Sci 2004 Jun;117(Pt 13):2827-39

Departamento de Bioquímica, UAM. Instituto de Investigaciones Biomédicas Alberto Sols (CSIC-UAM), Arturo Duperier 4, 28029 Madrid, Spain.

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http://dx.doi.org/10.1242/jcs.01145DOI Listing
June 2004
89 Reads
40 Citations
5.432 Impact Factor

Snail mediates E-cadherin repression by the recruitment of the Sin3A/histone deacetylase 1 (HDAC1)/HDAC2 complex.

Mol Cell Biol 2004 Jan;24(1):306-19

Departamento de Bioquimica, Instituto de Investigaciones Biomédicas "Alberto Sols," Madrid, Spain.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC303344PMC
http://dx.doi.org/10.1128/mcb.24.1.306-319.2004DOI Listing
January 2004
55 Reads
233 Citations
4.780 Impact Factor

Transforming growth factor beta-1 induces snail transcription factor in epithelial cell lines: mechanisms for epithelial mesenchymal transitions.

J Biol Chem 2003 Jun 28;278(23):21113-23. Epub 2003 Mar 28.

Instituto de Investigaciones Biomédicas "Alberto Sols" (CSIC-UAM) and Departamento de Bioquímica (UAM), Arturo Duperier 4, 28029 Madrid, Spain.

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http://dx.doi.org/10.1074/jbc.M211304200DOI Listing
June 2003
11 Reads
181 Citations
4.573 Impact Factor

The transcription factor Slug represses E-cadherin expression and induces epithelial to mesenchymal transitions: a comparison with Snail and E47 repressors.

J Cell Sci 2003 Feb;116(Pt 3):499-511

Instituto de Investigaciones Biomédicas "Alberto Sols" (CSIC-UAM), Arturo Duperier, 4, 28029 Madrid, Spain.

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http://dx.doi.org/10.1242/jcs.00224DOI Listing
February 2003
45 Reads
318 Citations
5.432 Impact Factor

Top co-authors

Amparo Cano
Amparo Cano

Departamento de Bioquímica

25
David Lyden
David Lyden

Children's Cancer and Blood Foundation Laboratories

10
Gema Moreno-Bueno
Gema Moreno-Bueno

Centro Nacional de Investigaciones Oncológicas

9
Francisco Portillo
Francisco Portillo

Christian-Albrechts-University of Kiel

9
Jacqueline Bromberg
Jacqueline Bromberg

Memorial Sloan Kettering Cancer Center

5
Irina Matei
Irina Matei

Children's Cancer and Blood Foundation Laboratories

5
Caitlin Williams
Caitlin Williams

School of Biological Sciences

5
Vanesa Santos
Vanesa Santos

Departamento de Bioquímica

5
Manel Esteller
Manel Esteller

Bellvitge Biomedical Research Institute (IDIBELL)

5