Heather L Osswald

Heather L Osswald

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Heather L Osswald

Heather L Osswald

Publications by authors named "Heather L Osswald"

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18Publications

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Simultaneous Online Monitoring of Multiple Reactions Using a Miniature Mass Spectrometer.

Anal Chem 2017 07 15;89(13):6969-6975. Epub 2017 Jun 15.

Department of Chemistry, Purdue University , 560 Oval Drive, West Lafayette, Indiana 47907, United States.

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http://dx.doi.org/10.1021/acs.analchem.7b00119DOI Listing
July 2017

Recent Progress in the Development of HIV-1 Protease Inhibitors for the Treatment of HIV/AIDS.

J Med Chem 2016 06 22;59(11):5172-208. Epub 2016 Jan 22.

Department of Chemistry and Department of Medicinal Chemistry, Purdue University , West Lafayette, Indiana 47907, United States.

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http://pubs.acs.org/doi/10.1021/acs.jmedchem.5b01697
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http://dx.doi.org/10.1021/acs.jmedchem.5b01697DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5598487PMC
June 2016

X-ray structure and inhibition of the feline infectious peritonitis virus 3C-like protease: Structural implications for drug design.

Bioorg Med Chem Lett 2015 Nov 13;25(22):5072-7. Epub 2015 Oct 13.

Departments of Biochemistry and Biological Sciences, Purdue University, West Lafayette, IN, USA; Centers for Cancer Research & Drug Discovery, Purdue University, West Lafayette, IN, USA; Department of Chemistry, Purdue University, West Lafayette, IN, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2015.10.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5896745PMC
November 2015

Structure-based design of potent HIV-1 protease inhibitors with modified P1-biphenyl ligands: synthesis, biological evaluation, and enzyme-inhibitor X-ray structural studies.

J Med Chem 2015 Jul 24;58(13):5334-43. Epub 2015 Jun 24.

§Departments of Hematology and Infectious Diseases, Kumamoto University Graduate School of Medical and Pharmaceutical Sciences, Kumamoto 860-8556, Japan.

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http://dx.doi.org/10.1021/acs.jmedchem.5b00676DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4765733PMC
July 2015

Enantioselective Synthesis of Dioxatriquinane Structural Motifs for HIV-1 Protease Inhibitors Using a Cascade Radical Cyclization.

Tetrahedron Lett 2015 Jun;56(23):3314-3317

Department of Chemistry and Department of Medicinal Chemistry, Purdue University, 560 Oval Drive, West Lafayette, Indiana 47907, United States.

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https://linkinghub.elsevier.com/retrieve/pii/S00404039150002
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http://dx.doi.org/10.1016/j.tetlet.2015.01.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4500529PMC
June 2015

BACE1 (β-secretase) inhibitors for the treatment of Alzheimer's disease.

Chem Soc Rev 2014 Oct;43(19):6765-813

Department of Chemistry and Department of Medicinal Chemistry, Purdue University, West Lafayette, IN 47907, USA.

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http://dx.doi.org/10.1039/c3cs60460hDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4159447PMC
October 2014

Design and synthesis of potent macrocyclic HIV-1 protease inhibitors involving P1-P2 ligands.

Org Biomol Chem 2014 Sep;12(35):6842-54

Departments of Chemistry and Medicinal Chemistry, Purdue University, West Lafayette, IN 47907, USA.

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http://dx.doi.org/10.1039/c4ob00738gDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4133278PMC
September 2014

Highly potent HIV-1 protease inhibitors with novel tricyclic P2 ligands: design, synthesis, and protein-ligand X-ray studies.

J Med Chem 2013 Sep 15;56(17):6792-802. Epub 2013 Aug 15.

Department of Chemistry and Department of Medicinal Chemistry, Purdue University , West Lafayette, Indiana 47907, United States.

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http://dx.doi.org/10.1021/jm400768fDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3800042PMC
September 2013