Publications by authors named "Heather Hampel"

100Publications

Genome-wide Modeling of Polygenic Risk Score in Colorectal Cancer Risk.

Authors:
Minta Thomas Lori C Sakoda Michael Hoffmeister Elisabeth A Rosenthal Jeffrey K Lee Franzel J B van Duijnhoven Elizabeth A Platz Anna H Wu Christopher H Dampier Albert de la Chapelle Alicja Wolk Amit D Joshi Andrea Burnett-Hartman Andrea Gsur Annika Lindblom Antoni Castells Aung Ko Win Bahram Namjou Bethany Van Guelpen Catherine M Tangen Qianchuan He Christopher I Li Clemens Schafmayer Corinne E Joshu Cornelia M Ulrich D Timothy Bishop Daniel D Buchanan Daniel Schaid David A Drew David C Muller David Duggan David R Crosslin Demetrius Albanes Edward L Giovannucci Eric Larson Flora Qu Frank Mentch Graham G Giles Hakon Hakonarson Heather Hampel Ian B Stanaway Jane C Figueiredo Jeroen R Huyghe Jessica Minnier Jenny Chang-Claude Jochen Hampe John B Harley Kala Visvanathan Keith R Curtis Kenneth Offit Li Li Loic Le Marchand Ludmila Vodickova Marc J Gunter Mark A Jenkins Martha L Slattery Mathieu Lemire Michael O Woods Mingyang Song Neil Murphy Noralane M Lindor Ozan Dikilitas Paul D P Pharoah Peter T Campbell Polly A Newcomb Roger L Milne Robert J MacInnis Sergi Castellví-Bel Shuji Ogino Sonja I Berndt Stéphane Bézieau Stephen N Thibodeau Steven J Gallinger Syed H Zaidi Tabitha A Harrison Temitope O Keku Thomas J Hudson Veronika Vymetalkova Victor Moreno Vicente Martín Volker Arndt Wei-Qi Wei Wendy Chung Yu-Ru Su Richard B Hayes Emily White Pavel Vodicka Graham Casey Stephen B Gruber Robert E Schoen Andrew T Chan John D Potter Hermann Brenner Gail P Jarvik Douglas A Corley Ulrike Peters Li Hsu

Am J Hum Genet 2020 Sep 5;107(3):432-444. Epub 2020 Aug 5.

Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA; Department of Biostatistics, University of Washington, Seattle, WA 98195, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2020.07.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7477007PMC
September 2020

Stakeholder perspectives on overcoming barriers to cascade testing in Lynch syndrome: A qualitative study.

Cancer Prev Res (Phila) 2020 Jul 29. Epub 2020 Jul 29.

Division of Pharmaceutical Outcomes and Policy, University of North Carolina at Chapel Hill

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http://dx.doi.org/10.1158/1940-6207.CAPR-20-0141DOI Listing
July 2020

Unexpected expression of mismatch repair protein is more commonly seen with pathogenic missense than with other mutations in Lynch syndrome.

Hum Pathol 2020 Jul 8;103:34-41. Epub 2020 Jul 8.

Department of Pathology, The Ohio State University Wexner Medical Center, Columbus, OH, USA. Electronic address:

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http://dx.doi.org/10.1016/j.humpath.2020.07.001DOI Listing
July 2020

Physical activity and risks of breast and colorectal cancer: a Mendelian randomisation analysis.

Nat Commun 2020 01 30;11(1):597. Epub 2020 Jan 30.

Section of Nutrition and Metabolism, International Agency for Research on Cancer, Lyon, France.

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http://dx.doi.org/10.1038/s41467-020-14389-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6992637PMC
January 2020

Circulating Levels of Insulin-like Growth Factor 1 and Insulin-like Growth Factor Binding Protein 3 Associate With Risk of Colorectal Cancer Based on Serologic and Mendelian Randomization Analyses.

Gastroenterology 2020 04 27;158(5):1300-1312.e20. Epub 2019 Dec 27.

Section of Nutrition and Metabolism, International Agency for Research on Cancer, Lyon, France.

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http://dx.doi.org/10.1053/j.gastro.2019.12.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7152801PMC
April 2020

Cumulative Burden of Colorectal Cancer-Associated Genetic Variants Is More Strongly Associated With Early-Onset vs Late-Onset Cancer.

Authors:
Alexi N Archambault Yu-Ru Su Jihyoun Jeon Minta Thomas Yi Lin David V Conti Aung Ko Win Lori C Sakoda Iris Lansdorp-Vogelaar Elisabeth F P Peterse Ann G Zauber David Duggan Andreana N Holowatyj Jeroen R Huyghe Hermann Brenner Michelle Cotterchio Stéphane Bézieau Stephanie L Schmit Christopher K Edlund Melissa C Southey Robert J MacInnis Peter T Campbell Jenny Chang-Claude Martha L Slattery Andrew T Chan Amit D Joshi Mingyang Song Yin Cao Michael O Woods Emily White Stephanie J Weinstein Cornelia M Ulrich Michael Hoffmeister Stephanie A Bien Tabitha A Harrison Jochen Hampe Christopher I Li Clemens Schafmayer Kenneth Offit Paul D Pharoah Victor Moreno Annika Lindblom Alicja Wolk Anna H Wu Li Li Marc J Gunter Andrea Gsur Temitope O Keku Rachel Pearlman D Timothy Bishop Sergi Castellví-Bel Leticia Moreira Pavel Vodicka Ellen Kampman Graham G Giles Demetrius Albanes John A Baron Sonja I Berndt Stefanie Brezina Stephan Buch Daniel D Buchanan Antonia Trichopoulou Gianluca Severi María-Dolores Chirlaque Maria-José Sánchez Domenico Palli Tilman Kühn Neil Murphy Amanda J Cross Andrea N Burnett-Hartman Stephen J Chanock Albert de la Chapelle Douglas F Easton Faye Elliott Dallas R English Edith J M Feskens Liesel M FitzGerald Phyllis J Goodman John L Hopper Thomas J Hudson David J Hunter Eric J Jacobs Corinne E Joshu Sébastien Küry Sanford D Markowitz Roger L Milne Elizabeth A Platz Gad Rennert Hedy S Rennert Fredrick R Schumacher Robert S Sandler Daniela Seminara Catherine M Tangen Stephen N Thibodeau Amanda E Toland Franzel J B van Duijnhoven Kala Visvanathan Ludmila Vodickova John D Potter Satu Männistö Korbinian Weigl Jane Figueiredo Vicente Martín Susanna C Larsson Patrick S Parfrey Wen-Yi Huang Heinz-Josef Lenz Jose E Castelao Manuela Gago-Dominguez Victor Muñoz-Garzón Christoph Mancao Christopher A Haiman Lynne R Wilkens Erin Siegel Elizabeth Barry Ban Younghusband Bethany Van Guelpen Sophia Harlid Anne Zeleniuch-Jacquotte Peter S Liang Mengmeng Du Graham Casey Noralane M Lindor Loic Le Marchand Steven J Gallinger Mark A Jenkins Polly A Newcomb Stephen B Gruber Robert E Schoen Heather Hampel Douglas A Corley Li Hsu Ulrike Peters Richard B Hayes

Gastroenterology 2020 04 19;158(5):1274-1286.e12. Epub 2019 Dec 19.

Division of Epidemiology, Department of Population Health, New York University School of Medicine, New York, New York. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2019.12.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7103489PMC
April 2020

Tumor Budding Detection System in Whole Slide Pathology Images.

J Med Syst 2019 Dec 18;44(2):38. Epub 2019 Dec 18.

Center for Biomedical Informatics, Wake Forest School of Medicine, Winston-Salem, NC, 27101, USA.

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http://dx.doi.org/10.1007/s10916-019-1515-yDOI Listing
December 2019

Implementing universal cancer screening programs can help sustain genomic medicine programs.

Per Med 2020 01 4;17(1):9-13. Epub 2019 Dec 4.

Sanford R Weiss, MD, Center for Hereditary Colorectal Neoplasia, Cleveland Clinic, 9500 Euclid Ave., Cleveland, OH 44195, USA.

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http://dx.doi.org/10.2217/pme-2019-0126DOI Listing
January 2020

MSH6 immunohistochemical heterogeneity in colorectal cancer: comparative sequencing from different tumor areas.

Hum Pathol 2020 02 27;96:104-111. Epub 2019 Nov 27.

Department of Pathology, The Ohio State University Wexner Medical Center, Columbus, OH 43210. Electronic address:

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http://dx.doi.org/10.1016/j.humpath.2019.11.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191319PMC
February 2020

"Histology of colorectal adenocarcinoma with double somatic mismatch-repair mutations is indistinguishable from those caused by Lynch syndrome"-reply.

Hum Pathol 2019 07 7;89:116-117. Epub 2019 May 7.

Department of Internal Medicine, Division of Human Genetics, The Ohio State University Wexner Medical Center, Columbus, OH.; Department of Pathology, The Ohio State University Wexner Medical Center, Columbus, OH.. Electronic address:

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http://dx.doi.org/10.1016/j.humpath.2019.04.017DOI Listing
July 2019

Hereditary Colorectal Cancer Syndromes.

Semin Oncol Nurs 2019 02 19;35(1):58-78. Epub 2019 Jan 19.

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http://dx.doi.org/10.1016/j.soncn.2018.12.011DOI Listing
February 2019

Discovery of common and rare genetic risk variants for colorectal cancer.

Authors:
Jeroen R Huyghe Stephanie A Bien Tabitha A Harrison Hyun Min Kang Sai Chen Stephanie L Schmit David V Conti Conghui Qu Jihyoun Jeon Christopher K Edlund Peyton Greenside Michael Wainberg Fredrick R Schumacher Joshua D Smith David M Levine Sarah C Nelson Nasa A Sinnott-Armstrong Demetrius Albanes M Henar Alonso Kristin Anderson Coral Arnau-Collell Volker Arndt Christina Bamia Barbara L Banbury John A Baron Sonja I Berndt Stéphane Bézieau D Timothy Bishop Juergen Boehm Heiner Boeing Hermann Brenner Stefanie Brezina Stephan Buch Daniel D Buchanan Andrea Burnett-Hartman Katja Butterbach Bette J Caan Peter T Campbell Christopher S Carlson Sergi Castellví-Bel Andrew T Chan Jenny Chang-Claude Stephen J Chanock Maria-Dolores Chirlaque Sang Hee Cho Charles M Connolly Amanda J Cross Katarina Cuk Keith R Curtis Albert de la Chapelle Kimberly F Doheny David Duggan Douglas F Easton Sjoerd G Elias Faye Elliott Dallas R English Edith J M Feskens Jane C Figueiredo Rocky Fischer Liesel M FitzGerald David Forman Manish Gala Steven Gallinger W James Gauderman Graham G Giles Elizabeth Gillanders Jian Gong Phyllis J Goodman William M Grady John S Grove Andrea Gsur Marc J Gunter Robert W Haile Jochen Hampe Heather Hampel Sophia Harlid Richard B Hayes Philipp Hofer Michael Hoffmeister John L Hopper Wan-Ling Hsu Wen-Yi Huang Thomas J Hudson David J Hunter Gemma Ibañez-Sanz Gregory E Idos Roxann Ingersoll Rebecca D Jackson Eric J Jacobs Mark A Jenkins Amit D Joshi Corinne E Joshu Temitope O Keku Timothy J Key Hyeong Rok Kim Emiko Kobayashi Laurence N Kolonel Charles Kooperberg Tilman Kühn Sébastien Küry Sun-Seog Kweon Susanna C Larsson Cecelia A Laurie Loic Le Marchand Suzanne M Leal Soo Chin Lee Flavio Lejbkowicz Mathieu Lemire Christopher I Li Li Li Wolfgang Lieb Yi Lin Annika Lindblom Noralane M Lindor Hua Ling Tin L Louie Satu Männistö Sanford D Markowitz Vicente Martín Giovanna Masala Caroline E McNeil Marilena Melas Roger L Milne Lorena Moreno Neil Murphy Robin Myte Alessio Naccarati Polly A Newcomb Kenneth Offit Shuji Ogino N Charlotte Onland-Moret Barbara Pardini Patrick S Parfrey Rachel Pearlman Vittorio Perduca Paul D P Pharoah Mila Pinchev Elizabeth A Platz Ross L Prentice Elizabeth Pugh Leon Raskin Gad Rennert Hedy S Rennert Elio Riboli Miguel Rodríguez-Barranco Jane Romm Lori C Sakoda Clemens Schafmayer Robert E Schoen Daniela Seminara Mitul Shah Tameka Shelford Min-Ho Shin Katerina Shulman Sabina Sieri Martha L Slattery Melissa C Southey Zsofia K Stadler Christa Stegmaier Yu-Ru Su Catherine M Tangen Stephen N Thibodeau Duncan C Thomas Sushma S Thomas Amanda E Toland Antonia Trichopoulou Cornelia M Ulrich David J Van Den Berg Franzel J B van Duijnhoven Bethany Van Guelpen Henk van Kranen Joseph Vijai Kala Visvanathan Pavel Vodicka Ludmila Vodickova Veronika Vymetalkova Korbinian Weigl Stephanie J Weinstein Emily White Aung Ko Win C Roland Wolf Alicja Wolk Michael O Woods Anna H Wu Syed H Zaidi Brent W Zanke Qing Zhang Wei Zheng Peter C Scacheri John D Potter Michael C Bassik Anshul Kundaje Graham Casey Victor Moreno Goncalo R Abecasis Deborah A Nickerson Stephen B Gruber Li Hsu Ulrike Peters

Nat Genet 2019 01 3;51(1):76-87. Epub 2018 Dec 3.

Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

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http://www.nature.com/articles/s41588-018-0286-6
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http://dx.doi.org/10.1038/s41588-018-0286-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358437PMC
January 2019

Recent Advances in Lynch Syndrome: Diagnosis, Treatment, and Cancer Prevention.

Am Soc Clin Oncol Educ Book 2018 May;38:101-109

From the Dana-Farber Cancer Institute, Brigham & Women's Hospital, and Harvard Medical School, Boston, MA; The Ohio State University Comprehensive Cancer Center, Columbus, OH.

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http://dx.doi.org/10.1200/EDBK_208341DOI Listing
May 2018

Cancer Risks for PMS2-Associated Lynch Syndrome.

J Clin Oncol 2018 10 30;36(29):2961-2968. Epub 2018 Aug 30.

Sanne W. ten Broeke, Heleen M. van der Klift, Carli M.J. Tops, Manon Suerink, Frederik J. Hes, Hans F.A. Vasen, Juul T. Wijnen, and Maartje Nielsen, Leiden University Medical Center, Leiden; Encarna Gomez Garcia, Maastricht University Medical Center, Maastricht; Nicoline Hoogerbrugge, Arjen R. Mensenkamp, and Liesbeth Spruijt, Radboud University Medical Center, Nijmegen; Tom G.W. Letteboer, University Medical Center, Utrecht; Theo A.M. van Os and Egbert J.W. Redeker, Academic Medical Center, Amsterdam; Maran J.W. Olderode-Berends and Yvonne J. Vos, University of Groningen; University Medical Center Groningen, Groningen; Anja Wagner, Erasmus Medical Center, Rotterdam, the Netherlands; Stefan Aretz, University of Bonn; University Hospital Bonn, Bonn; Christoph Engel, Leipzig University; Medizinisch Genetisches Zentrum Bayerstr, Leipzig; Magnus von Knebel Doeberitz, University of Heidelberg; German Cancer Research Center, Heidelberg; Pål Møller, University of Witten-Herdecke, Wuppertal; Nils Rahner, Heinrich-Heine-University, Düsseldorf; Hans K. Schackert, Technische Universität Dresden, Dresden; Verena Steinke-Lange, Medizinische Klinik und Poliklinik IV Campus Innenstadt, Klinikum der Universität München, Munich, Germany; Pål Møller, The Norwegian Radium Hospital; Oslo University Hospital, Oslo, Norway; Inge Bernstein, Hvidovre Hospital, Hvidovre, and Aalborg University Hospital, Aalborg, Denmark; Daniel D. Buchanan, Mark Clendenning, John L. Hopper, Mark A. Jenkins, Christophe Rosty, Ingrid Winship, and Aung Ko Win, The University of Melbourne; Daniel D. Buchanan, Ingrid Winship, and Aung Ko Win, Royal Melbourne Hospital, Parkville, Melbourne, Victoria; Rodney Scott, University of Newcastle, Newcastle, New South Wales, Australia; Albert de la Chapelle, Heather L. Hampel, Rachel Pearlman, and Leigha Senter, The Ohio State University Comprehensive Cancer Center, Columbus, OH; Gabriel Capella and Marta Pineda, Institut d'Investigació Biomédica de Bellvitge, Barcelona, Spain; Steven Gallinger, Mount Sinai Hospital, Toronto, Ontario, Canada; Jane C. Figueiredo and Robert Haile, Cedars-Sinai Medical Center, Los Angeles, CA; Loic Le Marchand, University of Hawaii Cancer Center, Honolulu, HI; Annika Lindblom, Karolinska Institutet; Karolinska University Hospital, Stockholm, Sweden; Noralane M. Lindor, Mayo Clinic Arizona, Scottsdale, AZ; Polly A. Newcomb, Fred Hutchinson Cancer Research Center; University of Washington, Seattle, WA; and Stephen Thibodeau, Mayo Clinic, Rochester, MN.

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http://ascopubs.org/doi/10.1200/JCO.2018.78.4777
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http://dx.doi.org/10.1200/JCO.2018.78.4777DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349460PMC
October 2018

Modified capture-recapture estimates of the number of families with Lynch syndrome in Central Ohio.

Fam Cancer 2019 01;18(1):67-73

Department of Laboratory Medicine, University of Washington, 1959 NE Pacific Street, NW120, Box 357110, Seattle, WA, 98195-7110, USA.

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http://dx.doi.org/10.1007/s10689-018-0096-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6324998PMC
January 2019

Delivery Of Cascade Screening For Hereditary Conditions: A Scoping Review Of The Literature.

Health Aff (Millwood) 2018 05;37(5):801-808

Heather Hampel is associate director of the Division of Human Genetics and of biospecimen research, and a professor of internal medicine, all at the Ohio State University Comprehensive Cancer Center, in Columbus.

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http://dx.doi.org/10.1377/hlthaff.2017.1630DOI Listing
May 2018

Population Screening for Hereditary Colorectal Cancer.

Authors:
Heather Hampel

Surg Oncol Clin N Am 2018 04;27(2):319-325

Division of Human Genetics, Department of Internal Medicine, The Ohio State University Comprehensive Cancer Center, 2012 Kenny Road, Room 257, Columbus, OH 43221, USA. Electronic address:

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http://dx.doi.org/10.1016/j.soc.2017.11.006DOI Listing
April 2018

Colorectal Carcinomas With Isolated Loss of PMS2 Staining by Immunohistochemistry.

Arch Pathol Lab Med 2018 Apr 16;142(4):523-528. Epub 2018 Jan 16.

From the Departments of Pathology (Drs Alpert, Setia, Xiao, and Hart) and Medicine (Dr Kupfer), University of Chicago, Chicago, Illinois; the Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania (Dr Reetesh Pai); the Department of Pathology, Brigham and Womens Hospital, Boston, Massachusetts (Dr Srivastava); the Departments of Medicine (Ms McKinnon) and Pathology and Laboratory Medicine (Dr Wilcox), University of Vermont Medical Center, Burlington; the Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, New York (Dr Yantiss); the Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles (Drs Arcega and Wang); the Department of Pathology, Yale-New Haven Hospital, New Haven, Connecticut (Dr Robert); the Department of Pathology, Cleveland Clinic, Cleveland, Ohio (Drs Liu and Rish Pai); the Department of Pathology, University of Alabama, Birmingham (Dr Zhao); the Department of Pathology, University of Washington, Seattle (Dr Westerhoff); and the Departments of Internal Medicine (Ms Hampel) and Pathology (Dr Frankel), The Ohio State University Wexner Medical Center, Columbus. Dr Rish Pai is now with the Department of Laboratory Medicine and Pathology, Mayo Clinic, Scottsdale, Arizona. Dr Liu is now with the Department of Pathology, University of Florida, Gainesville. Dr Zhao is now with the Department of Pathology, Brigham and Womens Hospital, Boston, Massachusetts. Dr Westerhoff is now with the Department of Pathology, University of Michigan, Ann Arbor.

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http://dx.doi.org/10.5858/arpa.2017-0156-OADOI Listing
April 2018

Mutation Frequencies in Patients With Early-Onset Colorectal Cancer-Reply.

JAMA Oncol 2017 11;3(11):1587

Ohio State University Comprehensive Cancer Center, Department of Internal Medicine, Ohio State University Wexner Medical Center, Columbus.

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http://dx.doi.org/10.1001/jamaoncol.2017.1744DOI Listing
November 2017

Multigene Panel Testing Provides a New Perspective on Lynch Syndrome.

J Clin Oncol 2017 Aug 17;35(22):2568-2575. Epub 2017 May 17.

Carin R. Espenschied, Holly LaDuca, Shuwei Li, Rachel McFarland, and Chia-Ling Gau, Ambry Genetics, Clinical Diagnostics, Aliso Viejo, CA; and Heather Hampel, The Ohio State University Comprehensive Cancer Center, Columbus, OH.

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http://dx.doi.org/10.1200/JCO.2016.71.9260DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7186580PMC
August 2017

Lynch Syndrome Limbo: Patient Understanding of Variants of Uncertain Significance.

J Genet Couns 2017 Aug 26;26(4):866-877. Epub 2017 Jan 26.

Department of Development Sociology, Cornell University, New York, NY, USA.

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http://dx.doi.org/10.1007/s10897-017-0066-yDOI Listing
August 2017

Using Genetic Technologies To Reduce, Rather Than Widen, Health Disparities.

Health Aff (Millwood) 2016 08;35(8):1367-73

José M. Ordovás is director of the Nutrition and Genomics Laboratory at the Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University.

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http://dx.doi.org/10.1377/hlthaff.2015.1476DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5100696PMC
August 2016

Genetic counseling and cascade genetic testing in Lynch syndrome.

Authors:
Heather Hampel

Fam Cancer 2016 07;15(3):423-7

Division of Human Genetics, Department of Internal Medicine, The Ohio State University Comprehensive Cancer Center, 2001 Polaris Parkway, Columbus, OH, 43240, USA.

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http://dx.doi.org/10.1007/s10689-016-9893-5DOI Listing
July 2016

Patients with colorectal cancer associated with Lynch syndrome and MLH1 promoter hypermethylation have similar prognoses.

Genet Med 2016 09 11;18(9):863-8. Epub 2016 Feb 11.

Division of Medical Oncology, Department of Internal Medicine, The Ohio State University Comprehensive Cancer Center, Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, Columbus, Ohio, USA.

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http://dx.doi.org/10.1038/gim.2015.184DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5489337PMC
September 2016

Comparison of Prediction Models for Lynch Syndrome Among Individuals With Colorectal Cancer.

J Natl Cancer Inst 2016 Feb 18;108(2). Epub 2015 Nov 18.

Herbert Irving C omprehensive Cancer Center and Division of Digestive and Liver Diseases, Columbia University, Medical Center, New York, NY (FK); Department of Epidemiology and Cancer Control, St. Jude Children's Research Hospital, Memphis, TN (RPO); Department of Gastroenterology and Hepatology, Erasmus MC, Rotterdam, the Netherlands (CL); Statistical and Data Analysis Center, Harvard School Public Health, Boston, MA (CA); Population Sciences Division, Dana-Farber Cancer Institute, Boston, MA (RCM); Department of Oncology (JB) and Genetics Department (IV), University Hospital Vall d'Hebrón, Barcelona, Spain; Department of Gastroenterology, Hospital Clinic of Barcelona, IDIBAPS, CIBERehd, Barcelona, Spain (FB); Discipline of Genetics, Faculty of Medicine, Memorial University of Newfoundland, St John's, NL, Canada (RG); Department of Health Sciences Research, Mayo Clinic, Scottsdale, AZ (NML); Division of Molecular Genetics, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN (SNT); Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA (PN); Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Parkville, Victoria, Australia (AKW, MJ, DDB); Unit of Hereditary Digestive Tract Tumors, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy (LB, PS); Clinical Cancer Genetics Program, Ohio State University Comprehensive Cancer Center, Columbus, OH (HH); Division of Gastroenterology, Brigham and Women's Hospital, Boston, MA (SS); Harvard Medical School, Boston, MA (SS); Department of Public Health, Erasmus Medical Center, Rotterdam, the Netherlands (EWS); Oncogenomics Group, Genetic Epidemiology Laboratory, The University of Melbourne, Parkville, Victoria, Australia (DDB).

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http://dx.doi.org/10.1093/jnci/djv308DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4862416PMC
February 2016

Combined Microsatellite Instability, MLH1 Methylation Analysis, and Immunohistochemistry for Lynch Syndrome Screening in Endometrial Cancers From GOG210: An NRG Oncology and Gynecologic Oncology Group Study.

J Clin Oncol 2015 Dec 9;33(36):4301-8. Epub 2015 Nov 9.

Paul J. Goodfellow, Caroline C. Billingsley, David E. Cohn, Heather Hampel, Alexis S. Chassen, Luke V. Simmons, and Floor Backes, Ohio State University; Nilsa Ramirez, Research Institute at Nationwide Children's Hospital, Columbus, OH; Heather A. Lankes and Shamshad Ali, NRG Oncology Statistics and Data Management Center; Shashikant B. Lele, Roswell Park Cancer Institute, Buffalo; Michael L. Pearl, Stony Brook University Hospital, Stony Brook, NY; Russell J. Broaddus, University of Texas MD Anderson Cancer Center, Houston, TX; Colin C. Pritchard, University of Washington, Seattle, WA; Amy P. Schmidt, Feng Gao, Matthew A. Powell, and David Mutch, Washington University School of Medicine, St Louis, MO; Louise A. Brinton, National Cancer Institute, Washington, DC; Lisa M. Landrum, University of Oklahoma Health Sciences Center, Oklahoma City, OK; Melissa A. Geller, University of Minnesota, Minneapolis, MN; Paul A. DiSilvestro, Women and Infants Hospital of Rhode Island, Providence, RI; and Richard J. Zaino, Penn State Milton S. Hershey Medical Center, Hershey, PA.

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http://dx.doi.org/10.1200/JCO.2015.63.9518DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4678181PMC
December 2015

Certified Genetic Counselors: A Crucial Clinical Resource in the Management of Patients with Suspected Hereditary Cancer Syndromes.

Surg Oncol Clin N Am 2015 Oct;24(4):653-66

The Ohio State University Comprehensive Cancer Center, 2001 Polaris Parkway, Columbus, OH 43240, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S10553207150006
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http://dx.doi.org/10.1016/j.soc.2015.06.005DOI Listing
October 2015

American Society of Clinical Oncology Policy Statement Update: Genetic and Genomic Testing for Cancer Susceptibility.

J Clin Oncol 2015 Nov 31;33(31):3660-7. Epub 2015 Aug 31.

Mark E. Robson, Memorial Sloan Kettering Cancer Center; Mark E. Robson and Stephen M. Lipkin, Weill Cornell Medical College, New York, NY; Angela R. Bradbury and Susan M. Domchek, Hospital of the University of Pennsylvania, Philadelphia, PA; Banu Arun, MD Anderson Cancer Center, Houston, TX; James M. Ford, Stanford University Medical Center, Stanford, CA; Heather L. Hampel, Ohio State University Comprehensive Cancer Center, Columbus, OH; Sapna Syngal, Dana-Farber Cancer Institute, Boston, MA; Dana S. Wollins, American Society of Clinical Oncology, Alexandria, VA; and Noralane M. Lindor, Mayo Clinic, Scottsdale, AZ.

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http://ascopubs.org/doi/10.1200/JCO.2015.63.0996
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http://dx.doi.org/10.1200/JCO.2015.63.0996DOI Listing
November 2015

Colorectal Cancer Screening, Version 1.2015.

J Natl Compr Canc Netw 2015 Aug;13(8):959-68; quiz 968

From Duke Cancer Institute; Huntsman Cancer Institute at the University of Utah; University of Colorado Cancer Center; Yale Cancer Center/Smilow Cancer Hospital; Hereditary Colon Cancer Foundation; University of Alabama at Birmingham Comprehensive Cancer Center; City of Hope Comprehensive Cancer Center; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; Roswell Park Cancer Institute; Stanford Cancer Institute; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; UC San Diego Moores Cancer Center; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; The University of Texas MD Anderson Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; Moffitt Cancer Center; Mayo Clinic Cancer Center; Fred & Pamela Buffett Cancer Center; Dana-Farber/Brigham and Women's Cancer Center; Vanderbilt-Ingram Cancer Center; University of Michigan Comprehensive Cancer Center; Memorial Sloan Kettering Cancer Center; Fred Hutchinson Cancer Research Center/Seattle Cancer Care Alliance; Fox Chase Cancer Center; and National Comprehensive Cancer Network.

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http://www.jnccn.org/content/13/8/959.full.pdf
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http://dx.doi.org/10.6004/jnccn.2015.0116DOI Listing
August 2015

The cost-effectiveness of routine testing for Lynch syndrome in newly diagnosed patients with colorectal cancer in the United States: corrected estimates.

Genet Med 2015 Jun;17(6):510-1

Division of Human Genetics, Department of Internal Medicine, The Ohio State University Comprehensive Cancer Center, Columbus, Ohio, USA.

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http://www.nature.com/articles/gim201553
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http://dx.doi.org/10.1038/gim.2015.53DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4511954PMC
June 2015

Use of Whole Genome Sequencing for Diagnosis and Discovery in the Cancer Genetics Clinic.

EBioMedicine 2015 Jan;2(1):74-81

Department of Internal Medicine, UT Southwestern Medical Center, Dallas TX, 75390, USA ; Department of Cancer Genetics, UT Southwestern Medical Center, Dallas, TX, 75390, USA.

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http://dx.doi.org/10.1016/j.ebiom.2014.12.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4444225PMC
January 2015

Allele-specific imbalance mapping at human orthologs of mouse susceptibility to colon cancer (Scc) loci.

Int J Cancer 2015 Nov 29;137(10):2323-31. Epub 2015 May 29.

Division of Human Genetics, Department of Internal Medicine, The Ohio State Wexner Medical Center, Columbus, OH.

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http://dx.doi.org/10.1002/ijc.29599DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6995280PMC
November 2015

ACG clinical guideline: Genetic testing and management of hereditary gastrointestinal cancer syndromes.

Am J Gastroenterol 2015 Feb 3;110(2):223-62; quiz 263. Epub 2015 Feb 3.

Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, Utah, USA.

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http://dx.doi.org/10.1038/ajg.2014.435DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4695986PMC
February 2015

Preliminary validation of a consumer-oriented colorectal cancer risk assessment tool compatible with the US Surgeon General's My Family Health Portrait.

Genet Med 2015 Sep 18;17(9):753-6. Epub 2014 Dec 18.

Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1038/gim.2014.179DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5890930PMC
September 2015

A practice guideline from the American College of Medical Genetics and Genomics and the National Society of Genetic Counselors: referral indications for cancer predisposition assessment.

Genet Med 2015 Jan 13;17(1):70-87. Epub 2014 Nov 13.

Clinical and Translational Hereditary Cancer Program, Division of Genetic Medicine, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University, Nashville, Tennessee, USA.

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http://dx.doi.org/10.1038/gim.2014.147DOI Listing
January 2015

Creation of a network to promote universal screening for Lynch syndrome: the LynchSyndrome Screening Network.

J Genet Couns 2015 Jun 16;24(3):421-7. Epub 2014 Sep 16.

Lifecourse Epidemiology and Genomics Division, Michigan Dept. of Community Health, 201 Townsend, PO Box 30195, Lansing, MI, 48909, USA,

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http://dx.doi.org/10.1007/s10897-014-9770-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4547789PMC
June 2015

Microsatellite instability detection by next generation sequencing.

Clin Chem 2014 Sep 30;60(9):1192-9. Epub 2014 Jun 30.

Department of Laboratory Medicine, University of Washington, Seattle WA;

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http://dx.doi.org/10.1373/clinchem.2014.223677DOI Listing
September 2014

NCCN increases the emphasis on genetic/familial high-risk assessment in colorectal cancer.

Authors:
Heather Hampel

J Natl Compr Canc Netw 2014 May;12(5 Suppl):829-31

Presented by Heather Hampel, MS, Professor and Associate Director, Clinical Cancer Genetics Program, The Ohio State University Comprehensive Cancer Center, Columbus, Ohio.

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http://dx.doi.org/10.6004/jnccn.2014.0200DOI Listing
May 2014

Biallelic MUTYH mutations can mimic Lynch syndrome.

Eur J Hum Genet 2014 Nov 12;22(11):1334-7. Epub 2014 Feb 12.

1] Medizinische Klinik und Poliklinik IV, Campus Innenstadt, Klinikum der Universität München, Munich, Germany [2] MGZ - Medizinisch Genetisches Zentrum, Munich, Germany.

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http://dx.doi.org/10.1038/ejhg.2014.15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4200426PMC
November 2014

Prostate cancer incidence in males with Lynch syndrome.

Genet Med 2014 Jul 16;16(7):553-7. Epub 2014 Jan 16.

Division of Medical Oncology, Department of Internal Medicine, The Ohio State University Medical Center, Columbus, Ohio, USA.

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http://dx.doi.org/10.1038/gim.2013.193DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4289599PMC
July 2014

Analysis of induced pluripotent stem cells from a BRCA1 mutant family.

Stem Cell Reports 2013 3;1(4):336-49. Epub 2013 Oct 3.

Department of Internal Medicine, High Risk Cancer Genetics Program, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

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http://dx.doi.org/10.1016/j.stemcr.2013.08.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3849250PMC
October 2015

BRAF V600E mutation analysis simplifies the testing algorithm for Lynch syndrome.

Am J Clin Pathol 2013 Aug;140(2):177-83

Department of Pathology, Ohio State University Wexner Medical Center, Columbus, OH 43210, USA.

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http://dx.doi.org/10.1309/AJCPB9FOVH1HGKFRDOI Listing
August 2013

How do we approach the goal of identifying everybody with Lynch syndrome?

Fam Cancer 2013 Jun;12(2):313-7

The Ohio State University, Columbus, OH, USA.

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http://dx.doi.org/10.1007/s10689-013-9611-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4337020PMC
June 2013

Mismatch repair protein deficiency is common in sebaceous neoplasms and suggests the importance of screening for Lynch syndrome.

Am J Dermatopathol 2013 Apr;35(2):191-5

Department of Pathology, The Wexner Medical Center at The Ohio State University, Columbus, OH, USA.

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http://dx.doi.org/10.1097/DAD.0b013e31825f7efeDOI Listing
April 2013

Mismatch repair analysis of inherited MSH2 and/or MSH6 variation pairs found in cancer patients.

Hum Mutat 2012 Aug 11;33(8):1294-301. Epub 2012 Jun 11.

Division of Genetics, Department of Biosciences, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1002/humu.22119DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4273566PMC
August 2012

Endometrial cancer patients and compliance with genetic counseling: room for improvement.

Gynecol Oncol 2011 Dec 2;123(3):532-6. Epub 2011 Oct 2.

Division of Gynecologic Oncology, The Ohio State University College of Medicine, Columbus, OH, USA.

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http://dx.doi.org/10.1016/j.ygyno.2011.09.002DOI Listing
December 2011

Transition to the clinical doctorate: attitudes of the genetic counseling training program directors in North America.

J Genet Couns 2012 Feb 3;21(1):136-49. Epub 2011 Sep 3.

Master of Science Program in Genetic Counseling, Boston University School of Medicine, Boston, MA, USA.

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http://dx.doi.org/10.1007/s10897-011-9407-4DOI Listing
February 2012

An American founder mutation in MLH1.

Int J Cancer 2012 May 30;130(9):2088-95. Epub 2011 Aug 30.

Human Cancer Genetics Program, Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA.

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http://dx.doi.org/10.1002/ijc.26233DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3266960PMC
May 2012

The search for unaffected individuals with Lynch syndrome: do the ends justify the means?

Cancer Prev Res (Phila) 2011 Jan;4(1):1-5

Division of Human Genetics, Department of Internal Medicine, The Ohio State University Comprehensive Cancer Center, 2001 Polaris Parkway, Columbus, OH 43240, USA.

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http://dx.doi.org/10.1158/1940-6207.CAPR-10-0345DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3076593PMC
January 2011

Clinical relevance of microsatellite instability in colorectal cancer.

J Clin Oncol 2010 Jul 1;28(20):3380-7. Epub 2010 Jun 1.

Ohio State University, Comprehensive Cancer Center, Columbus, OH 43210, USA.

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http://ascopubs.org/doi/10.1200/JCO.2009.27.0652
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http://dx.doi.org/10.1200/JCO.2009.27.0652DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2903331PMC
July 2010

Point: justification for Lynch syndrome screening among all patients with newly diagnosed colorectal cancer.

Authors:
Heather Hampel

J Natl Compr Canc Netw 2010 May;8(5):597-601

Division of Human Genetics, Department of Internal Medicine, The Ohio State University Comprehensive Cancer Center, Columbus, Ohio 43240, USA.

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http://dx.doi.org/10.6004/jnccn.2010.0044DOI Listing
May 2010

The cost-effectiveness of genetic testing strategies for Lynch syndrome among newly diagnosed patients with colorectal cancer.

Genet Med 2010 Feb;12(2):93-104

Office of Public Health Genomics, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.

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http://dx.doi.org/10.1097/GIM.0b013e3181cd666cDOI Listing
February 2010