Publications by authors named "Heajung L Nguyen"

5 Publications

  • Page 1 of 1

Pulmonary vein and left atrial posterior wall isolation for the treatment of atrial fibrillation: Comparable outcomes for adults with congenital heart disease.

J Cardiovasc Electrophysiol 2021 Jul 14;32(7):1868-1876. Epub 2021 Apr 14.

UCLA Cardiac Arrhythmia Center, David Geffen School of Medicine, Los Angeles, California, USA.

Introduction: Optimal treatment strategies for ACHD with AF are unknown. This study sought to assess outcomes of pulmonary vein isolation (PVI) ± left atrial (LA), posterior wall isolation (PWI) for adults with congenital heart disease (ACHD), and atrial fibrillation (AF).

Methods: A retrospective review of all cryoballoon (CB) PVI ± PWI procedures at a single center over a 3-year period were performed. Clinical characteristics and outcomes for patients with and without ACHD were compared. The primary outcome was the occurrence of atrial tachyarrhythmia at 12-months postablation after a 90-day blanking period.

Results: Three-hundred and sixteen patients (mean: 63 ± 12 years, [63% male]) underwent CB PVI ± PWI during the study, including 31 (10%) ACHD (simple 35%, moderate 39% complex 26%; nonparoxysmal AF in 52%). ACHD was younger (51 vs. 64 years; p < .001) with a lower CHADS DS -VASc score (1.2 vs. 2.1; p = .001) but had a greater LA diameter (4.9 vs. 4.0 cm; p < .001) and a number of prior cardioversions (0.9 vs. 0.4; p < .001) versus controls. 12-month freedom from recurrent AF was similar for ACHD and controls (76% vs. 80%; p = .6) and remained nonsignificant in multivariate analysis (hazard ratio: 1.8, 95% confidence interval: 0.7-5.1; p = .22). At 12-months postablation, 75% of ACHD versus 93% of control patients were off antiarrhythmic drug therapy (p = .07).

Conclusion: This study demonstrates younger age and lower conventional stroke risk, yet clinically advanced AF for ACHD relative to controls. CB PVI ± PWI was an effective strategy for the treatment of AF among all forms of ACHD with similar 12-month outcomes as compared to controls.
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http://dx.doi.org/10.1111/jce.15027DOI Listing
July 2021

Confessions of a stressed heart: The brain-heart relationship is complicated.

Trends Cardiovasc Med 2021 Mar 26. Epub 2021 Mar 26.

UCLA Cardiac Arrhythmia Center, University of California, 100 Medical Plaza, Suite 660, Los Angeles, CA 90095-1679, United States. Electronic address:

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http://dx.doi.org/10.1016/j.tcm.2021.03.004DOI Listing
March 2021

Sympathetic Denervation for Treatment of Ventricular Arrhythmias.

J Atr Fibrillation 2020 Jun-Jul;13(1):2404. Epub 2020 Jun 30.

UCLA Cardiac Arrhythmia Center, David Geffen School of Medicine at UCLA, Los Angeles, CA.

Ventricular arrhythmias are a major cause of morbidity and mortality in patients with heart disease. A growing understanding of the cardiac autonomic nervous system's crucial role in the pathogenesis of ventricular arrhythmias has led to the development of several neuromodulation therapies. Sympathetic neuromodulation is being increasingly utilized to treat ventricular arrhythmias refractory to medical therapy and catheter ablation. There is a growing body of preclinical and clinical evidence supporting the use of thoracic epidural anesthesia, stellate ganglion blockade, cardiac sympathetic denervation, and renal denervation in the treatment of recurrent ventricular arrhythmias. This review summarizes the relevant literature and discusses approaches to sympathetic neuromodulation, particularly in the management of scar-related ventricular arrhythmias.
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http://dx.doi.org/10.4022/jafib.2404DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7533141PMC
June 2020

Ventricular Tachycardia in Dilated Cardiomyopathy: Is it Time for Genetic Testing in All Patients?

JACC Clin Electrophysiol 2020 09 10;6(9):1115-1117. Epub 2020 Sep 10.

UCLA Cardiac Arrhythmia Center, University of California, Los Angeles, California, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jacep.2020.05.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8189639PMC
September 2020

Tweeting the Meeting.

Circ Cardiovasc Qual Outcomes 2018 11;11(11):e005018

Division of Cardiology (M.T.T., H.L.N., B.H.W., W.H.S., J.K.H.), University of California Los Angeles.

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http://dx.doi.org/10.1161/CIRCOUTCOMES.118.005018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6383719PMC
November 2018
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