Hayley Whitaker

Hayley Whitaker

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Hayley Whitaker

Hayley Whitaker

Publications by authors named "Hayley Whitaker"

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Genetic correlates of prostate cancer visibility (and invisibility) on mpMRI: It's time to take stock.

BJU Int 2019 Oct 10. Epub 2019 Oct 10.

UCL Division of Surgery and Interventional Science, University College London, London, UK.

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http://dx.doi.org/10.1111/bju.14919DOI Listing
October 2019

Stroma in normal and cancer wound healing.

FEBS J 2019 Aug 15;286(15):2909-2920. Epub 2019 Apr 15.

Molecular Diagnostics and Therapeutics Group, Charles Bell House, Division of Surgery and Interventional Science, University College London, UK.

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http://dx.doi.org/10.1111/febs.14842DOI Listing
August 2019

The Oncogene Metadherin Interacts with the Known Splicing Proteins YTHDC1, Sam68 and T-STAR and Plays a Novel Role in Alternative mRNA Splicing.

Cancers (Basel) 2019 Aug 23;11(9). Epub 2019 Aug 23.

Molecular Therapeutics and Diagnostics Group, University College London, London W1W 7TS, UK.

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http://dx.doi.org/10.3390/cancers11091233DOI Listing
August 2019

VERDICT MRI for Prostate Cancer: Intracellular Volume Fraction versus Apparent Diffusion Coefficient.

Radiology 2019 May 2;291(2):391-397. Epub 2019 Apr 2.

From the UCL Centre for Medical Imaging, University College London, 2nd Floor Charles Bell House, 43-45 Foley Street, London W1W 7TS, England (E.W.J., E.B.C., H.S.S., J.O., M.B.A., D. Atkinson, S.P.); UCL Centre for Medical Image Computing, London, England (E.B.C., U.F., B.Y., S.O., D.H., D. Alexander, E.P.); UCL Centre for Molecular Intervention, London, England (H.P., S.H., H.W.); Department of Histopathology, University College Hospital, London, England (D.P., M.R.J., A.F.); Department of Radiology (J.C.) and Centre for Medical Imaging (J.C., W.P., A.S.), University College Hospital, London, England; Division of Surgery and Interventional Science, Faculty of Medical Sciences, University College London, London, England (F.G., A.G., C.M.M., M.E.); and Department of Surgery and Cancer, Imperial College London, London, England (H.U.A.).

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http://dx.doi.org/10.1148/radiol.2019181749DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6493214PMC
May 2019

Sequencing of prostate cancers identifies new cancer genes, routes of progression and drug targets.

Nat Genet 2018 05 16;50(5):682-692. Epub 2018 Apr 16.

The Institute of Cancer Research, London, UK.

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http://www.nature.com/articles/s41588-018-0086-z
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http://dx.doi.org/10.1038/s41588-018-0086-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372064PMC
May 2018

Asporin is a stromally expressed marker associated with prostate cancer progression.

Br J Cancer 2017 Mar 2;116(6):775-784. Epub 2017 Feb 2.

Department of Surgery, Division of Urology, McGill University and the Cancer Research Program of the Research Institute of McGill University Health Centre, Montreal, Quebec H4A 3J1, Canada.

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http://dx.doi.org/10.1038/bjc.2017.15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5355923PMC
March 2017

Whole blood mRNA in prostate cancer reveals a four-gene androgen regulated panel.

Endocr Relat Cancer 2016 10 30;23(10):797-812. Epub 2016 Aug 30.

Uro-Oncology Research GroupCancer Research UK Cambridge Institute, Robinson Way, Cambridge, UK Biomarker InitiativeCancer Research UK Cambridge Institute, Robinson Way, Cambridge, UK Molecular Diagnostics and Therapeutics GroupUniversity College London, London, UK

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http://dx.doi.org/10.1530/ERC-16-0287DOI Listing
October 2016

The Early Effects of Rapid Androgen Deprivation on Human Prostate Cancer.

Eur Urol 2016 08 10;70(2):214-8. Epub 2015 Nov 10.

Cancer Research UK Cambridge Institute, Li Ka Shing Centre, Cambridge, UK; Department of Urology, Cambridge University Hospitals NHS Trust, Cambridge, UK; Nuffield Department of Surgery, University of Oxford, John Radcliffe Hospital, Headington, Oxford, UK.

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http://dx.doi.org/10.1016/j.eururo.2015.10.042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4926724PMC
August 2016

HES5 silencing is an early and recurrent change in prostate tumourigenesis.

Endocr Relat Cancer 2015 Apr 5;22(2):131-44. Epub 2015 Jan 5.

Cancer Research UK Cambridge InstituteUniversity of Cambridge, Cambridge, CB2 0RE, UKDivision of Genetics and EpidemiologyThe Institute of Cancer Research, Sutton, UKDepartment of Biological Sciences and School of MedicineUniversity of East Anglia, Norwich, UKRoyal Marsden NHS Foundation TrustLondon and Sutton, UKDepartments of PathologyUrologySurgical OncologyAddenbrooke's Hospital, Hills Road, Cambridge, UK

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http://dx.doi.org/10.1530/ERC-14-0454DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4335379PMC
April 2015

Analysis of the genetic phylogeny of multifocal prostate cancer identifies multiple independent clonal expansions in neoplastic and morphologically normal prostate tissue.

Nat Genet 2015 Apr 2;47(4):367-372. Epub 2015 Mar 2.

Urological Research Laboratory, Cancer Research UK Cambridge Research Institute, Cambridge, UK.

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https://ueaeprints.uea.ac.uk/52532/2/39739_3_merged_14193243
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http://www.nature.com/doifinder/10.1038/ng.3221
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http://dx.doi.org/10.1038/ng.3221DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4380509PMC
April 2015

Mobile DNA in cancer. Extensive transduction of nonrepetitive DNA mediated by L1 retrotransposition in cancer genomes.

Science 2014 Aug;345(6196):1251343

Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, UK.

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http://dx.doi.org/10.1126/science.1251343DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4380235PMC
August 2014

Regulation of the localisation and function of the oncogene LYRIC/AEG-1 by ubiquitination at K486 and K491.

Mol Oncol 2014 May 24;8(3):633-41. Epub 2014 Jan 24.

Uro-Oncology Research Group, Cancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK. Electronic address:

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http://doi.wiley.com/10.1016/j.molonc.2014.01.009
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http://dx.doi.org/10.1016/j.molonc.2014.01.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4013555PMC
May 2014

Prognostic and therapeutic impact of argininosuccinate synthetase 1 control in bladder cancer as monitored longitudinally by PET imaging.

Cancer Res 2014 Feb 27;74(3):896-907. Epub 2013 Nov 27.

Authors' Affiliations: Barts Cancer Institute-a Cancer Research UK Center of Excellence, John Vane Science Center, Queen Mary University of London; Department of Medicine, Imperial College, Charing Cross Campus; St Bartholomew's Hospital, Barts Health NHS Trust, West Smithfield, London; Wellcome Trust Center for Human Genetics, Oxford; Cancer Research UK Cambridge Research Institute, Li Ka Shing Center; Hutchison/MRC Research Center, University of Cambridge, Medical Research Council Cancer Unit; Pharmacometrics Ltd., Cambridge; Dundee Cancer Center, University of Dundee, Ninewells Hospital, Dundee, United Kingdom; Laboratory of Cancer Genetics and Translational Oncology, S Croce General Hospital, Cuneo, Italy; Department of Structural Biology, Medical University of Lodz, Lodz, Poland; Polaris Group, San Diego, California; Department of Pathology, Chi-Mei Medical Center; Department of Biotechnology, Southern Taiwan University of Science and Technology, Tainan, Taiwan; and National Institute of Cancer Research, National Health Research Institutes, Tainan, Taiwan.

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http://dx.doi.org/10.1158/0008-5472.CAN-13-1702DOI Listing
February 2014

Method for sampling tissue for research which preserves pathological data in radical prostatectomy.

Prostate 2013 Jan 16;73(2):194-202. Epub 2012 Jul 16.

Department of Histopathology, Cambridge University Hospitals NHS Foundation Trust, Cambridge Biomedical Campus, Cambridge, UK.

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http://dx.doi.org/10.1002/pros.22556DOI Listing
January 2013

Role of the HSP90-associated cochaperone p23 in enhancing activity of the androgen receptor and significance for prostate cancer.

Mol Endocrinol 2012 Oct 16;26(10):1694-706. Epub 2012 Aug 16.

Androgen Signaling Laboratory, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, United Kingdom.

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http://dx.doi.org/10.1210/me.2012-1056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5416955PMC
October 2012

RAS pathways in prostate cancer - mediators of hormone resistance?

Curr Cancer Drug Targets 2010 Dec;10(8):834-9

Uro-Oncology Research Group, Cancer Research UK Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge, CB2 0RE, UK.

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December 2010

The potential value of microseminoprotein-beta as a prostate cancer biomarker and therapeutic target.

Prostate 2010 Feb;70(3):333-40

Uro-Oncology Research Group, CRUK Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge, UK.

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http://dx.doi.org/10.1002/pros.21059DOI Listing
February 2010

Alterations in beta-catenin expression and localization in prostate cancer.

Prostate 2008 Aug;68(11):1196-205

Uro-Oncology Research Group, Cancer Research UK Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge, UK.

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http://dx.doi.org/10.1002/pros.20780DOI Listing
August 2008

Structural basis for the nuclear import of the human androgen receptor.

J Cell Sci 2008 Apr 4;121(Pt 7):957-68. Epub 2008 Mar 4.

Uro-Oncology Research Group, Cancer Research UK Cambridge Research Institute, Robinson Way, Cambridge, CB2 0RE, UK.

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http://jcs.biologists.org/cgi/doi/10.1242/jcs.022103
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http://dx.doi.org/10.1242/jcs.022103DOI Listing
April 2008

Labeling and identification of LNCaP cell surface proteins: a pilot study.

Prostate 2007 Jun;67(9):943-54

Uro-Oncology Research Group, CRUK Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge, UK.

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http://dx.doi.org/10.1002/pros.20580DOI Listing
June 2007

Androgen receptor is targeted to distinct subcellular compartments in response to different therapeutic antiandrogens.

Clin Cancer Res 2004 Nov;10(21):7392-401

Prostate Cancer Research Group, Department of Cancer Medicine, Faculty of Medicine, Imperial College London, London, United Kingdom.

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http://dx.doi.org/10.1158/1078-0432.CCR-04-0388DOI Listing
November 2004