Publications by authors named "Hayato Shimizu"

14 Publications

  • Page 1 of 1

Black-pooling sign: A novel intravascular ultrasound imaging marker that predicts stent edge hematoma growth.

Anatol J Cardiol 2021 Apr;25(4):E15

Department of Cardiovascular Medicine, Faculty of Medicine, Jichi Medical University; Shimotsuke-Japan.

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http://dx.doi.org/10.14744/AnatolJCardiol.2020.49921DOI Listing
April 2021

F-FDG PET-CT in adult-onset Still's disease.

BMJ Case Rep 2021 Mar 29;14(3). Epub 2021 Mar 29.

General Internal Medicine, Kobe City Medical Center General Hospital, Kobe, Hyogo, Japan

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http://dx.doi.org/10.1136/bcr-2021-242717DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8009220PMC
March 2021

Impact of Guidewire Route on Severe Dissection After Balloon Angioplasty for Femoropopliteal Chronic Total Occlusion Lesions: An Intravascular Ultrasound Analysis.

Eur J Vasc Endovasc Surg 2021 05 22;61(5):830-836. Epub 2021 Feb 22.

Department of Cardiology, Kurashiki Central Hospital, Okayama, Japan.

Objective: To determine the impact of the guidewire route on severe dissection after balloon angioplasty for femoropopliteal chronic total occlusion (CTO) lesions using a new intravascular ultrasound (IVUS) assessed classification scheme corresponding to a conventional angiographic classification scheme.

Methods: Images for 21 femoropopliteal CTO lesions treated endovascularly between May 2018 and December 2019 were used for analysis. IVUS images after guidewire passage and those after balloon angioplasty were evaluated at 1 cm intervals. Cross sectional images were obtained (n = 219) and divided into two groups by the guidewire route: those in which the guidewire passed through the inner half of the luminal radius (central wiring group, 139 cross sectional images) and those in which the guidewire passed through the outer half of the luminal radius (eccentric wiring group, 80 cross sectional images). Angiographically severe dissection was defined as Type C or greater according to the National Heart, Lung, and Blood Institute classification, to which six dissection morphology patterns were applied based on IVUS images (Types A - E2).

Results: Central wiring was achieved in an average of 69.6 ± 28.0% of the CTO length from per limb analysis. Among the IVUS assessed dissection morphology patterns, Types D - E2 were more frequently correlated with angiographically severe dissection than were Types A - C (57.5% vs. 13.7%, p < .001). Multivariable analysis showed that soft plaque was a predictive factor for (odds ratio [OR] 2.14; 95% confidence interval [CI] 1.007 - 4.72; p = .048) and central wiring was a protective factor (OR 0.27; 95% CI 0.14 - 0.49; p < .001) against Type D - E2 dissection patterns assessed by IVUS after balloon angioplasty.

Conclusion: Lesions with Type D - E2 dissection patterns assessed by IVUS were correlated with angiographically severe dissection. Central wiring may be useful for preventing severe dissection after balloon angioplasty for femoropopliteal CTO lesions.
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http://dx.doi.org/10.1016/j.ejvs.2021.01.014DOI Listing
May 2021

Noteworthy Cardiovascular Involvement with Sporadic Late-onset Nemaline Myopathy.

Intern Med 2021 Jul 22;60(14):2327-2332. Epub 2021 Feb 22.

Division of Neurology, Department of Medicine, Jichi Medical University School of Medicine, Japan.

Cardiac involvement has recently been the focus of sporadic late-onset nemaline myopathy (SLONM). However, right ventricular failure and pulmonary hypertension, in addition to repetitive cardiac arrest, are noteworthy characteristics of SLONM. We herein report a 66-year-old woman with SLONM whose main symptoms were cardiac arrest, right ventricular failure, and pulmonary hypertension. Despite permanent pacemaker replacement, cardiac arrest occurred repetitively, and even with continuous positive airway pressure, right ventricular failure and pulmonary hypertension persisted. The patient was finally diagnosed with SLONM by a muscle biopsy. Our case suggests the possibility of cardiovascular involvement in SLONM, especially right ventricular failure and pulmonary hypertension.
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http://dx.doi.org/10.2169/internalmedicine.6068-20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8355391PMC
July 2021

Cardiovascular outcome and home blood pressure in relation to silent myocardial ischemia in a clinical population: The J-HOP study.

J Clin Hypertens (Greenwich) 2020 12 21;22(12):2214-2220. Epub 2020 Oct 21.

Division of Cardiovascular Medicine, Department of Medicine, Jichi Medical University School of Medicine, Tochigi, Japan.

Several guidelines recommend measuring home blood pressure (BP) and lowering blood pressure than ever before. But several studies reported that lowering diastolic blood pressure (DBP) increased the incidence of coronary artery disease (CAD). We analyzed 3605 individuals who underwent both home and office BP monitoring over 14 days and baseline Hs-cTnT measurement and identified follow-up data of the Japan Morning Surge-Home Blood Pressure (J-HOP) study who had a history of or risk factors for cardiovascular disease. During a mean follow-up period of 6.4 years (23 173 person-years), 114 coronary artery disease and 81 stroke events occurred. Elevated Hs-cTnT (≥0.014 ng/mL) was observed in 298 patients (8.3%). In the group with non-elevated Hs-cTnT (<0.014 ng/mL, n = 3307), an adjusted Cox hazard model showed that home systolic BP (SBP) was associated with a risk of stroke incidence (hazard ratio [HR] per 1 SD, 1.62; 95% confidence interval [CI], 1.29-2.03). This association was also observed in office SBP (HR per 1 SD, 1.43; 95%CI, 1.07-1.91). There was no association between office or home BP and CAD events in the group with non-elevated Hs-cTnT. In the group with elevated Hs-cTnT, an adjusted Cox hazard model showed that home DBP was associated with a risk of CAD incidence (HR per 1 SD, 0.54; 95%CI, 0.30-0.99). However, this association was not observed in office DBP. In patients with elevated Hs-cTnT, which is a marker of subclinical myocardial ischemia, excessive lowering of home DBP may be associated with a risk of incident CAD.
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http://dx.doi.org/10.1111/jch.14076DOI Listing
December 2020

Differential Impact of the Renal Resistive Index on Future Cardiovascular Events in Hospitalized Atherosclerotic Cardiovascular Patients According to Left Ventricular Ejection Fraction - The Jichi Vascular Hemodynamics in Hospitalized Cardiovascular Patients (J-VAS) Study.

Circ J 2020 08 1;84(9):1544-1551. Epub 2020 Aug 1.

Division of Cardiovascular Medicine, Jichi Medical University School of Medicine.

Background: Determinants of poor outcome in atherosclerotic cardiovascular disease (ASCVD) according to left ventricular ejection fraction (LVEF) are unclear. The renal resistive index (RRI) correlates well with atherosclerotic vascular damage, which, in turn, is correlated with cardiovascular outcomes. This study investigated whether high RRI is associated with poor cardiovascular outcomes in ASCVD patients classified by LVEF.Methods and Results:Records of 1,598 acute coronary syndromes (ACS) and acute decompensated heart failure (ADHF) patients, categorized into preserved (p), mid-range (mr), and reduced (r) ejection fraction (EF) groups (EF ≥50% [n=1,130], 40-50% [n=223], and <40% [n=245], respectively), were analyzed retrospectively. The primary endpoint was any cardiovascular-related event: fatal and non-fatal ACS, ADHF, stroke, and sudden cardiac death. Over 1.9-years follow-up (3,030 person-years), 233 events occurred: 122, 37, and 74 in the pEF, mrEF, and rEF groups, respectively. Adjusted Cox regression analysis revealed RRI ≥0.8 was associated with the primary endpoint in the pEF group (hazard ratio [HR] 1.67; 95% confidence interval [CI] 1.09-2.56), but not in the mrEF or rEF groups. The primary endpoint risk of pEF patients with an RRI ≥0.8 was comparable to that of mrEF patients using the pEF+RRI <0.8 group as the reference (HR 1.89 [95% CI 1.26-2.83] and 1.77 [95% CI 1.19-2.63], respectively).

Conclusions: RRI was associated with the risk of cardiovascular events in ASCVD patients with pEF.
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http://dx.doi.org/10.1253/circj.CJ-19-1166DOI Listing
August 2020

Disseminated cryptococcosis with granuloma formation in idiopathic CD4 lymphocytopenia.

J Infect Chemother 2020 Feb 23;26(2):257-260. Epub 2019 Jul 23.

Department of General Internal Medicine, Kobe City Medical Center General Hospital, Hyogo, Japan. Electronic address:

Idiopathic CD4 lymphocytopenia (ICL) is a rare disease characterized by marked loss of CD4 T-cells without human immunodeficiency virus infection. CD4 T-cells play an important role in granuloma formation in cryptococcal infection. Thus far, among ICL patients, it has not been concluded definitely whether granuloma is formed or not. We report the case of a 39-year-old woman with ICL and disseminated cryptococcal infection with granuloma formation. She was referred to our department because of a lung mass, osteolytic lesion, and a subcutaneous mass identified on a computed tomography scan, and an elevated C-reactive protein level. Cryptococcus neoformans was isolated from the tissues. She also had marked CD4 lymphocytopenia (33 cells/μL), without human immunodeficiency virus infection. In a biopsy specimen of the lung mass, granulomas containing CD4 T-cells were observed. The cryptococcosis was treated with liposomal amphotericin B followed by fluconazole and she was found to be cured. The CD4 T-cell count was persistently low. This case showed that granulomas containing CD4 T-cells can be formed in ICL patients with cryptococcal infection despite very low CD4 T-cell counts.
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http://dx.doi.org/10.1016/j.jiac.2019.07.006DOI Listing
February 2020

[A Case of Systemic Polyarteritis Nodosa Presenting with Scrotal Pain].

Hinyokika Kiyo 2019 Apr;65(4):127-131

The Department of Urology, Kobe City Medical Center General Hospital.

A 76-year-old man with a history of hypertension was admitted with high fever and left scrotal pain. Laboratory findings revealed high serum C-reactive protein levels. The left epididymis appeared to be swollen on computed tomography. The patient was diagnosed with bacterial epididymitis and treatment with antibiotics was initiated. Despite treatment, his left scrotal pain and fever did not improve. Additionally, he developed right scrotal and posterior neck pain. For histopathological diagnosis, a left high orchiectomy was performed and the findings revealed thickened arteriolar walls with infiltration of inflammatory cells around the testis, leading to a final diagnosis of systemic polyarteritis nodosa. Treatment with steroids led to complete resolution of the patient's systemic pain and inflammation.
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http://dx.doi.org/10.14989/ActaUrolJap_65_4_127DOI Listing
April 2019

Case Image: A case of severely calcified neoatherosclerosis-embedded stent struts clearly documented with optical coherence tomography imaging.

Turk Kardiyol Dern Ars 2019 01;47(1):83

Division of Cardiovascular Medicine, Department of Internal Medicine, Jichi Medical University School of Medicine, Tochigi-ken, Japan.

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http://dx.doi.org/10.5543/tkda.2018.86094DOI Listing
January 2019

Anti-mitochondrial antibody-associated myositis with eosinophilia and dropped head.

eNeurologicalSci 2018 Jun 23;11:15-16. Epub 2018 May 23.

Department of General Internal Medicine, Kobe City Medical Center General Hospital, Hyogo 650-0047, Japan.

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http://dx.doi.org/10.1016/j.ensci.2018.05.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6006915PMC
June 2018

F-FDG PET-CT in a patient with methotrexate-associated lymphoproliferative disorder.

J Gen Fam Med 2018 01 2;19(1):34-35. Epub 2017 Dec 2.

Department of General Internal Medicine Kobe City Medical Center General Hospital Kobe Japan.

F-FDG PET-CT clearly demonstrated the disease activity of MTX-LPD.
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http://dx.doi.org/10.1002/jgf2.145DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5763021PMC
January 2018

Elevation of plasma granzyme B levels after acute myocardial infarction.

Circ J 2009 Mar 15;73(3):503-7. Epub 2009 Jan 15.

Department of Cardiology, Jichi Medical University, Shimotsuke, Japan.

Background: Apoptosis is reported to play an important role in left ventricular (LV) remodeling after acute myocardial infarction (AMI). Granzyme B is a member of the serine esterase family, which has an important role in cellular apoptosis and extracellular matrix degradation.

Methods And Results: Peripheral blood samples were obtained from 33 patients with a first-onset AMI treated by percutaneous coronary intervention (mean age: 61.4+/-8.7 years old) on days 1, 7 and 14 after onset. Plasma levels of tumor necrosis factor (TNF)-alpha, a soluble form of the Fas ligand (sFasL), and granzyme B were measured. TIMI grade 3 recanalization was accomplished in all patients within 12 h after onset. The LV end-diastolic volume index (LVEDVI) was calculated on day 1 and at 6 months after onset. Plasma levels of TNF-alpha, sFasL and granzyme B increased significantly on days 7 and 14 after onset of AMI. Stepwise multivariate regression analysis showed that the plasma granzyme B level on day 14 is a significant explanatory variable for changes in the LVEDVI.

Conclusions: Plasma levels of granzyme B increased after AMI, which might be an important factor in the progression of late LV remodeling after AMI.
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http://dx.doi.org/10.1253/circj.cj-08-0668DOI Listing
March 2009

Age-related changes of the concentrations of select elements in the prostates of Japanese.

Biol Trace Elem Res 2009 Mar 18;127(3):211-27. Epub 2008 Oct 18.

Laboratory of Cell Biology, Department of Anatomy, Nara Medical University School of Medicine, Kashihara, Nara, 634-8521, Japan.

To elucidate compositional changes of the prostate with aging, the authors investigated age-related changes of elements in the prostates and the relationships among their elements using Japanese and Thai. After ordinary dissections by students at Nara Medical University and Chiang Mai University were finished, the prostates were resected from the subjects. Fifty-seven Japanese subjects ranged in age from 65 to 101 years (average age = 82.5 +/- 7.8 years), whereas 13 Thai subjects ranged in age from 43 to 86 years (average age = 67.9 +/- 11.9 years). After ashing with nitric acid and perchloric acid, element contents were determined by inductively coupled plasma-atomic emission spectrometry. It was found that although there were no significant correlations between age and seven element contents, such as Ca, P, S, Mg, Zn, Fe, and Na, in the prostates of Japanese, high contents of Ca (>5 mg/g) and P (>4 mg/g) were contained in one fourth of the prostates of Japanese over 70 years of age. In the prostates of Thai, a significant direct correlation was found between age and Ca content, but it was not found between age and the other element contents, such as P, S, Mg, Zn, Fe, and Na. Regarding the relationships among their elements, extremely significant direct correlations were found among the contents of Ca, P, Mg, Zn, and Na in the prostates of Japanese. In the prostates of Thai, significant direct correlations were found among the contents of Ca, Mg, and Zn, but no significant correlations were found between Ca and P contents and between P and Mg contents. Regarding the relationships among their elements, there were differences between the prostates of Japanese and Thai. To examine whether element contents changed in prostatic hypertrophy, the transverse width of the Japanese prostates was measured. No significant correlations were found between the transverse width and element contents, such as Ca, P, S, Mg, Zn, Fe, and Na, in the Japanese prostates. Therefore, it is unlikely that the increase of elements results in prostatic hypertrophy.
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http://dx.doi.org/10.1007/s12011-008-8241-5DOI Listing
March 2009

Relationship between low evaluation by recipients under 40 years old of health interviews by occupational health nurses and deterioration in health checkup results over one year.

Keio J Med 2008 Jun;57(2):90-8

Department of Environmental and Occupational Health, Toho University School of Medicine, Tokyo, Japan.

Improvement of an unhealthy lifestyle decreases the risk of incidence and mortality from lifestyle-related disease. One method for the improvement of an unhealthy lifestyle is interviewing for health and consultation regarding a healthy lifestyle to recipients of health checkups by public health nurses. Original articles in occupational health for recipients' evaluation in health checkups as longitudinal studies are rare. The purpose of the present study was to investigate in a longitudinal study the relationship between recipients' evaluation of interviews by public health nurses in a health checkup and variations in health checkup results for one year. Data on 750 male white collar workers who underwent a company health checkup in 1999 and 2000 were analyzed. The variation in health checkup results for one year from 1999 to 2000 was studied by computing odds ratios in a conditional logistic analysis of the recipients who set a low value on the interview for health by occupational health nurses in the health checkup in 1999 and those who did not. It was found that among the subjects who set a low value on the usefulness of the interview by the occupational health nurses, the numbers of the subjects whose body mass index (BMI) and triglyceride value (TG) were healthy (normal) in 1999 and unhealthy (abnormal) in 2000 were significantly greater than those of the subjects whose values were unhealthy in 1999 and healthy in 2000, while such a finding was not detected in the subjects who set a high value on the interview. The differences for BMI and TG between (i) differences between deterioration and improvement of health checkup results in the subjects who evaluated the interview lowly and (ii) those in the subjects who did not were statistically significant as interactions. It can be supposed that some of the subjects who set a low value on the usefulness of the interview by the occupational health nurses may be indifferent to their health status, indicating that low recipient evaluation of the interview for health in health checkup may be regarded as a risk factor of metabolic syndrome from the viewpoint of prevention.
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http://dx.doi.org/10.2302/kjm.57.90DOI Listing
June 2008
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