Publications by authors named "Hassen Bacha"

96Publications

Eugenol protects against citrinin-induced cytotoxicity and oxidative damages in cultured human colorectal HCT116 cells.

Environ Sci Pollut Res Int 2019 Oct 31;26(30):31374-31383. Epub 2019 Aug 31.

Laboratory of Research on Biologically Compatible Compounds, Faculty of Dental Medicine, Monastir University, rue Avicenne, 5019, Monastir, Tunisia.

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October 2019

Protective effects of kefir against deltamethrin-induced hepatotoxicity in rats.

Environ Sci Pollut Res Int 2019 Jun 7;26(18):18856-18865. Epub 2019 May 7.

Laboratory for Research on Biologically Compatible Compounds, Faculty of Dental Medicine, Rue Avicenne, Monastir, Tunisia.

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June 2019

Acute triflumuron exposure induces oxidative stress responses in liver and kidney of Balb/C mice.

Environ Sci Pollut Res Int 2019 Feb 11;26(4):3723-3730. Epub 2018 Dec 11.

Laboratory for Research on Biologically Compatible Compounds, Faculty of Dental Medicine, Rue Avicenne, 5019, Monastir, Tunisia.

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February 2019

Protective effects of kefir against zearalenone toxicity mediated by oxidative stress in cultured HCT-116 cells.

Toxicon 2019 Jan 16;157:25-34. Epub 2018 Nov 16.

Laboratory for Research on Biologically Compatible Compounds, Faculty of Dentistry, Monastir, Tunisia.

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January 2019

Citrinin induces apoptosis in human HCT116 colon cancer cells through endoplasmic reticulum stress.

J Toxicol Environ Health A 2017 ;80(23-24):1230-1241

d Université Versailles St-Quentin, Inserm UMR-S 1180, Univ Paris-Sud, Université Paris Saclay , Chatenay-Malabry , France.

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December 2017

SIRT1 protects cardiac cells against apoptosis induced by zearalenone or its metabolites α- and β-zearalenol through an autophagy-dependent pathway.

Toxicol Appl Pharmacol 2017 01 23;314:82-90. Epub 2016 Nov 23.

Université Versailles St-Quentin, Inserm UMR-S 1180, Univ Paris-Sud, Université Paris Saclay, 92296 Chatenay-Malabry, France.

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January 2017

Evaluation of anti-proliferative and anti-inflammatory activities of Pelagia noctiluca venom in Lipopolysaccharide/Interferon-γ stimulated RAW264.7 macrophages.

Biomed Pharmacother 2016 Dec 18;84:1986-1991. Epub 2016 Nov 18.

Faculty of Dental Medicine of Monastir, Laboratory for Research on Biologically Compatible Compounds, Rue Avicenne, 5019 Monastir, Tunisia; University of Jendouba, AlFaeiz, Street Jamil Boutheina Jendouba 8100, Tunisia.

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December 2016

Combination of tacrolimus and mycophenolate mofetil induces oxidative stress and genotoxicity in spleen and bone marrow of Wistar rats.

Mutat Res 2016 Nov 7;810:48-55. Epub 2016 Oct 7.

Laboratory of Research on Biologically Compatible Compounds, Faculty of Dental Medicine, 5019 Monastir, Tunisie.

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November 2016

Crocin, the main active saffron constituent, mitigates dichlorvos-induced oxidative stress and apoptosis in HCT-116 cells.

Biomed Pharmacother 2016 Aug 6;82:65-71. Epub 2016 May 6.

Laboratory for Research on Biologically Compatible Compounds, Faculty of Dentistry, Rue Avicenne, 5019 Monastir, Tunisia. Electronic address:

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August 2016

Crocin protects human embryonic kidney cells (HEK293) from α- and β-Zearalenol-induced ER stress and apoptosis.

Environ Sci Pollut Res Int 2016 Aug 28;23(15):15504-14. Epub 2016 Apr 28.

Laboratory for Research on Biologically Compatible Compounds (LRSBC), Faculty of Dental Medicine, Rue Avicenne, 5019, Monastir, Tunisia.

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August 2016

Crocin protects the liver and kidney from patulin-induced apoptosis in vivo.

Environ Sci Pollut Res Int 2016 May 9;23(10):9799-808. Epub 2016 Feb 9.

Laboratory for Research on Biologically Compatible Compounds, Faculty of Dental Medicine, Monastir University, Rue Avicenne, 5019, Monastir, Tunisia.

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May 2016

Ochratoxin A and T-2 Toxin Induce Clonogenicity and Cell Migration in Human Colon Carcinoma and Fetal Lung Fibroblast Cell Lines.

J Biochem Mol Toxicol 2016 Mar 5;30(3):128-35. Epub 2016 Feb 5.

Laboratoire de Recherche sur les Substances Biologiquement Compatibles (LRSBC), Faculté de Médecine Dentaire, 5019, Monastir, Tunisia.

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March 2016

Cytotoxic effects induced by patulin, sterigmatocystin and beauvericin on CHO-K1 cells.

Food Chem Toxicol 2016 Mar 21;89:92-103. Epub 2016 Jan 21.

Laboratory of Toxicology, Faculty of Pharmacy, University of Valencia, Av. Vincent Andrés Estelles, 46100, Burjassot, Valencia, Spain. Electronic address:

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March 2016

Protective effect of mycophenolate mofetil against nephrotoxicity and hepatotoxicity induced by tacrolimus in Wistar rats.

J Physiol Biochem 2016 Jun 9;72(2):133-44. Epub 2016 Jan 9.

Laboratory of Research on Biologically Compatible Compounds, Dental Medicine Faculty, 5019, Monastir, Tunisia.

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June 2016

The potential effect of patulin on mice bearing melanoma cells: an anti-tumour or carcinogenic effect?

Tumour Biol 2016 May 30;37(5):6285-95. Epub 2015 Nov 30.

Laboratory for Research on Biologically Compatible Compounds, Faculty of Dental Medicine, Rue Avicenne, 5019, Monastir, Tunisia.

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May 2016

Activation of ER stress and apoptosis by α- and β-zearalenol in HCT116 cells, protective role of Quercetin.

Neurotoxicology 2016 Mar 14;53:334-342. Epub 2015 Nov 14.

Laboratory for Research on Biologically Compatible Compounds, Faculty of Dentistry, Rue Avicenne, 5019 Monastir, Tunisia. Electronic address:

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March 2016

Tissue oxidative stress induced by patulin and protective effect of crocin.

Neurotoxicology 2016 Mar 14;53:343-349. Epub 2015 Nov 14.

Laboratory for Research on Biologically Compatible Compounds, Faculty of Dental Medicine, Rue Avicenne, 5019, Monastir, Tunisia.

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March 2016

Beneficial effects of mycophenolate mofetil on cardiotoxicity induced by tacrolimus in wistar rats.

Exp Biol Med (Maywood) 2017 02 24;242(4):448-455. Epub 2016 Jul 24.

1 Laboratory of Research on Biologically Compatible Compounds, Dental Medicine Faculty, University of Monastir, 5019 Monastir, Tunisia.

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February 2017

Quercetin protects HCT116 cells from Dichlorvos-induced oxidative stress and apoptosis.

Cell Stress Chaperones 2016 Jan;21(1):179-186

Laboratory for Research on Biologically Compatible Compounds, Faculty of Dental Medicine, Rue Avicenne, 5000, Monastir, Tunisia.

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January 2016

The evaluate and compare the effects of the Tacrolimus and Sirolimus on the intestinal system using an intestinal cell culture model.

Toxicol Mech Methods 2016 13;26(1):54-60. Epub 2015 Oct 13.

a Laboratory of Research on Biologically Compatible Compounds , Faculty of Dental Medicine, University of Monastir , Monastir , Tunisia and.

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December 2016

Crocin and quercetin prevent PAT-induced apoptosis in mammalian cells: Involvement of ROS-mediated ER stress pathway.

Environ Toxicol 2016 Dec 27;31(12):1851-1858. Epub 2015 Aug 27.

Faculty of Dentistry, Laboratory for Research on Biologically Compatible Compounds, Rue Avicenne, Monastir, 5019, Tunisia.

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December 2016

Protective effect of Crocin against zearalenone-induced oxidative stress in liver and kidney of Balb/c mice.

Environ Sci Pollut Res Int 2015 Dec 2;22(23):19069-76. Epub 2015 Aug 2.

Laboratory for Research on Biologically Compatible Compounds, Faculty of Dental Medicine, Rue Avicenne, 5019, Monastir, Tunisia.

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December 2015

Crocin Prevents Patulin-Induced Acute Toxicity in Cardiac Tissues via the Regulation of Oxidative Damage and Apoptosis.

J Biochem Mol Toxicol 2015 Oct 11;29(10):479-488. Epub 2015 Jun 11.

Laboratory for Research on Biologically Compatible Compounds, Faculty of Dental Medicine, Rue Avicenne, Monastir, 5019, Tunisia.

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October 2015

Dichlorvos-induced toxicity in HCT116 cells: involvement of oxidative stress and apoptosis.

Pestic Biochem Physiol 2015 Mar 11;119:62-6. Epub 2015 Feb 11.

Faculty of Dentistry, Laboratory for Research on Biologically Compatible Compounds, Rue Avicenne, Monastir 5019, Tunisia.

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March 2015

Patulin induces apoptosis through ROS-mediated endoplasmic reticulum stress pathway.

Toxicol Sci 2015 Apr 9;144(2):328-37. Epub 2015 Jan 9.

*Laboratory for Research on Biologically Compatible Compounds, Faculty of Dentistry, Rue Avicenne, 5019 Monastir, Tunisia, INSERM UMR-S 1180, LabEx LERMIT, Faculty of Pharmacy, Université Paris-Sud, Faculté de Pharmacie, 92296 Châtenay-Malabry, France and Université de Versailles Saint Quentin en Yvelines, 78035 Versailles, France *Laboratory for Research on Biologically Compatible Compounds, Faculty of Dentistry, Rue Avicenne, 5019 Monastir, Tunisia, INSERM UMR-S 1180, LabEx LERMIT, Faculty of Pharmacy, Université Paris-Sud, Faculté de Pharmacie, 92296 Châtenay-Malabry, France and Université de Versailles Saint Quentin en Yvelines, 78035 Versailles, France *Laboratory for Research on Biologically Compatible Compounds, Faculty of Dentistry, Rue Avicenne, 5019 Monastir, Tunisia, INSERM UMR-S 1180, LabEx LERMIT, Faculty of Pharmacy, Université Paris-Sud, Faculté de Pharmacie, 92296 Châtenay-Malabry, France and Université de Versailles Saint Quentin en Yvelines, 78035 Versailles, France.

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April 2015

Combined effects of alternariols mixture on human colon carcinoma cells.

Toxicol Mech Methods 2015 Jan;25(1):56-62

Laboratory for Research on Biologically Compatible Compounds, Faculty of Dentistry , Rue Avicenne, Monastir , Tunisia .

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January 2015

In vitro investigation of toxicological interactions between the fusariotoxins deoxynivalenol and zearalenone.

Toxicon 2014 Jun 27;84:1-6. Epub 2014 Mar 27.

Laboratory for Research on Biologically Compatible Compounds, Faculty of Dentistry, Rue Avicenne, 5019 Monastir, Tunisia.

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June 2014

Antioxidant and antigenotoxic role of recombinant human erythropoeitin against alkylating agents: cisplatin and mitomycin C in cultured Vero cells.

Exp Biol Med (Maywood) 2013 Aug;238(8):943-50

Laboratory of Research on Biologically Compatible Compounds, Faculty of Dentistry, Monastir University, Tunisia.

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August 2013

Identification of proteins related to early changes observed in Human hepatocellular carcinoma cells after treatment with the mycotoxin Zearalenone.

Exp Toxicol Pathol 2013 Sep 3;65(6):809-16. Epub 2013 Jan 3.

Laboratory of Research on Biologically Compatible Compounds, Faculty of Dentistry, Rue Avicenne, Monastir, 5000, Tunisia.

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September 2013

Assessment of chromosomal aberrations and micronuclei in peripheral lymphocytes from tunisian hospital workers exposed to ionizing radiation.

Genet Test Mol Biomarkers 2013 Sep 6;17(9):650-5. Epub 2012 Dec 6.

Laboratory of Genetics (02/UR/08-03), University Medicinal School of Monastir, Monastir, Tunisia.

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September 2013

Protective effect of cactus cladode extract against cisplatin induced oxidative stress, genotoxicity and apoptosis in balb/c mice: combination with phytochemical composition.

BMC Complement Altern Med 2012 Jul 31;12:111. Epub 2012 Jul 31.

Laboratory of Research on Biologically Compatible Compounds, Faculty of Dentistry, Rue Avicenne, 5019, Monastir, Tunisia.

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July 2012

Impairment of the cell-to-matrix adhesion and cytotoxicity induced by the Mediterranean jellyfish Pelagia noctiluca venom and its fractions in cultured glioblastoma cells.

Lipids Health Dis 2012 Jun 28;11:84. Epub 2012 Jun 28.

Laboratory for Research on Biologically Compatible Compounds, Faculty of Dentistry, Rue Avicenne, Monastir 5019, Tunisia.

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June 2012

iTRAQ: a method to elucidate cellular responses to mycotoxin zearalenone.

J Appl Toxicol 2013 Jul 25;33(7):566-75. Epub 2012 Jun 25.

Laboratory of Research on Biologically Compatible Compounds, Faculty of Dentistry, Rue Avicenne, Monastir, 5000, Tunisia.

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July 2013

Analgesic and antibutyrylcholinestrasic activities of the venom prepared from the Mediterranean jellyfish Pelagia noctiluca (Forsskal, 1775).

Ann Clin Microbiol Antimicrob 2012 Jun 12;11:15. Epub 2012 Jun 12.

Laboratory for Research on Biologically Compatible Compounds, Faculty of Dentistry, Monastir university, Monastir, Tunisia.

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June 2012

Cell death induced by the Alternaria mycotoxin Alternariol.

Toxicol In Vitro 2012 Sep 20;26(6):915-23. Epub 2012 Apr 20.

Laboratory for Research on Biologically Compatible Compounds, Faculty of Dentistry, Rue Avicenne, 5019 Monastir, Tunisia.

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September 2012

The in vitro effects of zearalenone and T-2 toxins on Vero cells.

Exp Toxicol Pathol 2013 Jul 17;65(5):497-501. Epub 2012 Mar 17.

Laboratory of Research on Biologically Compatible Compounds, Faculty of Dentistry, Rue Avicenne, Monastir 5000, Tunisia.

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July 2013

Cell death in relation to DNA damage after exposure to the jellyfish Pelagia noctiluca nematocysts.

Environ Toxicol 2014 Mar 13;29(3):337-44. Epub 2012 Feb 13.

Laboratory for Research on Biologically Compatible Compounds, Faculty of Dentistry, Rue Avicenne, 5019 Monastir, Tunisia.

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March 2014

Involvement of mitochondria-mediated apoptosis in deoxynivalenol cytotoxicity.

Food Chem Toxicol 2012 May 17;50(5):1680-9. Epub 2012 Jan 17.

Laboratory for Research on Biologically Compatible Compounds, Faculty of Dentistry, Rue Avicenne, 5019 Monastir, Tunisia.

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May 2012

Induction of cytotoxicity of Pelagia noctiluca venom causes reactive oxygen species generation, lipid peroxydation induction and DNA damage in human colon cancer cells.

Lipids Health Dis 2011 Dec 9;10:232. Epub 2011 Dec 9.

Laboratory for Research on Biologically Compatible Compounds, Faculty of Dentistry, Rue Avicenne, 5019 Monastir, Tunisia.

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December 2011

Protective effect of recombinant human erythropoietin against cisplatin-induced oxidative stress and nephrotoxicity in rat kidney.

Int J Toxicol 2011 Oct;30(5):510-7

Laboratory of Research on Biologically Compatible Compounds, Faculty of Dentistry, Monastir, Tunisia.

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October 2011

Chemopreventive effect of cactus Opuntia ficus indica on oxidative stress and genotoxicity of aflatoxin B1.

Nutr Metab (Lond) 2011 Oct 18;8:73. Epub 2011 Oct 18.

Laboratory of Research on Biologically Compatible Compounds, Faculty of Dentistry, Rue Avicenne, 5019 Monastir, Tunisia.

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October 2011

Mechanism of Alternariol monomethyl ether-induced mitochondrial apoptosis in human colon carcinoma cells.

Toxicology 2011 Dec 6;290(2-3):230-40. Epub 2011 Oct 6.

Laboratory for Research on Biologically Compatible Compounds, Faculty of Dentistry, Rue Avicenne, 5019 Monastir, Tunisia.

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December 2011

Genotoxicity evaluation of dimethoate to experimental mice by micronucleus, chromosome aberration tests, and comet assay.

Int J Toxicol 2012 Jan-Feb;31(1):78-85. Epub 2011 Oct 12.

Laboratory of Research on Biologically Compatible Compounds, Faculty of Dentistry, 5019 Monastir, Tunisia.

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June 2012

Effect of aflatoxin B1 on nuclear receptors PXR, CAR, and AhR and their target cytochromes P450 mRNA expression in primary cultures of human hepatocytes.

Int J Toxicol 2012 Jan-Feb;31(1):86-93. Epub 2011 Oct 12.

Laboratoire de Recherche sur les Substances Biologiquement Compatibles, (LRSBC), Rue Avicenne, 5019 Monastir, Tunisia.

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June 2012

The mycotoxin, patulin, increases the expression of PXR and AhR and their target cytochrome P450s in primary cultured human hepatocytes.

Drug Chem Toxicol 2012 Jul 22;35(3):241-50. Epub 2011 Sep 22.

Laboratory of Research on Biologically Compatible Compounds, Faculty of Dentistry, Monastir, Tunisia.

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July 2012

Protective effect of recombinant human erythropoeitin against cisplatin cytotoxicity and genotoxicity in cultured Vero cells.

Exp Toxicol Pathol 2013 Jan 15;65(1-2):181-7. Epub 2011 Sep 15.

Laboratory of Research on Biologically Compatible Compounds, Faculty of Dentistry, Monastir University, Monastir, Tunisia.

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January 2013

In vitro and in vivo induction of chromosome aberrations by alpha- and beta-zearalenols: comparison with zearalenone.

Mutat Res 2011 Nov 26;726(1):42-6. Epub 2011 Aug 26.

Laboratory for Research on Biologically Compatible Compounds, Faculty of Dentistry, Monastir, Tunisia.

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November 2011

Protective effect of erythropoietin against cisplatin-induced nephrotoxicity in rats: antigenotoxic and antiapoptotic effect.

Drug Chem Toxicol 2012 Jan 12;35(1):89-95. Epub 2011 Aug 12.

Laboratory of Research on Biologically Compatible Compounds, Faculty of Dentistry, Monastir, Tunisia.

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January 2012

Recombinant human erythropoietin prevents cisplatin-induced genotoxicity in rat liver and heart tissues via an antioxidant process.

Drug Chem Toxicol 2012 Apr 11;35(2):134-40. Epub 2011 Aug 11.

Laboratory of Research on Biologically Compatible Compounds, Faculty of Dentistry, Monastir, Tunisia.

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April 2012

Ochratoxin A induces CYP3A4, 2B6, 3A5, 2C9, 1A1, and CYP1A2 gene expression in primary cultured human hepatocytes: a possible activation of nuclear receptors.

Drug Chem Toxicol 2012 Jan 11;35(1):71-80. Epub 2011 Aug 11.

Laboratory of Research on Biologically Compatible Compounds, Faculty of Dentistry, Monastir, Tunisia.

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January 2012

Genotoxicity associated with oxidative damage in the liver and kidney of mice exposed to dimethoate subchronic intoxication.

Environ Sci Pollut Res Int 2012 Feb 7;19(2):458-66. Epub 2011 Aug 7.

Laboratoire de Recherche sur Substances Biologiquement Compatibles, Faculté de Médecine Dentaire, Rue Avicenne, 5019 Monastir, Tunisia.

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February 2012

Is cell death induced by nematocysts extract of medusa Pelagia noctiluca related to oxidative stress?

Environ Toxicol 2013 Sep 1;28(9):498-506. Epub 2011 Aug 1.

Laboratory for Research on Biologically Compatible Compounds, Faculty of Dentistry, Rue Avicenne, 5019 Monastir, Tunisia.

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September 2013

Zearalenone activates pregnane X receptor, constitutive androstane receptor and aryl hydrocarbon receptor and corresponding phase I target genes mRNA in primary cultures of human hepatocytes.

Environ Toxicol Pharmacol 2011 Jan 15;31(1):79-87. Epub 2010 Sep 15.

Laboratory of Research on Biologically Compatible Compounds, Faculty of Dentistry, Rue Avicenne, 5019 Monastir, Tunisia.

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January 2011

Hsp70 expression as biomarkers of oxidative stress: mycotoxins' exploration.

Toxicology 2011 Sep 13;287(1-3):1-7. Epub 2011 Jun 13.

Laboratory of Research on Biologically Compatible Compounds, Faculty of Dentistry, Rue Avicenne, Monastir 5000, Tunisia.

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September 2011

Antioxidative and antigenotoxic effect of vitamin E against patulin cytotoxicity and genotoxicity in HepG2 cells.

Environ Toxicol 2013 Jun 7;28(6):299-306. Epub 2011 Jun 7.

Laboratory for Research on Biologically Compatible Compounds-LRSBC, Monastir University, Rue Avicenne, Monastir 5019, Tunisia.

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June 2013

Cytotoxicity effects of amiodarone on cultured cells.

Exp Toxicol Pathol 2012 Jul 18;64(5):425-30. Epub 2010 Nov 18.

Laboratory of Research on Biologically Compatible Compounds, Rue Avicenne, 5019 Monastir, Tunisia.

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July 2012

Presence of ochratoxin A in Tunisian blood nephropathy patients. Exposure level to OTA.

Exp Toxicol Pathol 2011 Nov 12;63(7-8):613-8. Epub 2010 Aug 12.

Laboratory for Research on Biologically Compatible Compounds, Faculty of Dentistry, Rue Avicenne, 5019 Monastir, Tunisia.

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November 2011

Evaluation of cultivar susceptibility and storage periods towards aflatoxin B1 contamination on pistachio nuts.

Mycotoxin Res 2010 Aug 6;26(3):199-203. Epub 2010 May 6.

Laboratory of Plant Protection, The National Institute for Agricultural Research, INRA Tunisia, Rue Hedi Karray, 2049, Ariana, Tunisia,

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August 2010

Sequential events of apoptosis induced by zearalenone in cultured hepatocarcinoma cells.

Mycotoxin Res 2010 Aug 20;26(3):187-97. Epub 2010 May 20.

Laboratory of Research on Biologically Compatible Compounds, Faculty of Dentistry, Rue Avicenne, Monastir, 5000, Tunisia.

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August 2010

Molecular events involved in ochratoxin A induced mitochondrial pathway of apoptosis, modulation by Bcl-2 family members.

Environ Toxicol 2011 Nov 12;26(6):579-90. Epub 2010 Apr 12.

Laboratory of Research on Biologically Compatible Compounds, Faculty of Dentistry, Rue Avicenne, Monastir 5000, Tunisia.

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November 2011

Ochratoxin A levels in spices and dried nuts consumed in Tunisia.

Food Addit Contam Part B Surveill 2010 ;3(1):52-7

a Laboratory for Research on Biologically Compatible Compounds, , Faculty of Dentistry , Rue Avicenne, 5019 Monastir , Tunisia.

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December 2014

Cytotoxicity and genotoxicity induced by aflatoxin B1, ochratoxin A, and their combination in cultured Vero cells.

J Biochem Mol Toxicol 2010 Jan-Feb;24(1):42-50

Laboratory of Research on Biologically Compatible Compounds, Faculty of Dentistry, Rue Avicenne, Monastir 5000, Tunisia.

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May 2010

Cytotoxic effects exerted by polyarylsulfone dialyser membranes depend on different sterilization processes.

Int Urol Nephrol 2011 Jun 1;43(2):483-90. Epub 2009 Oct 1.

Laboratoire de Recherche sur les Substances biologiquement Compatible (LRSBC), faculté de Medecine Dentaire, Monastir, Tunisia.

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June 2011

Comparative study of toxic effects of zearalenone and its two major metabolites alpha-zearalenol and beta-zearalenol on cultured human Caco-2 cells.

J Biochem Mol Toxicol 2009 Jul-Aug;23(4):233-43

Laboratoire de Recherche sur les Substances Biologiquement Compatibles, Faculté de Médecine Dentaire, Monastir, Tunisia.

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February 2010

Pathway of deoxynivalenol-induced apoptosis in human colon carcinoma cells.

Toxicology 2009 Oct 5;264(1-2):104-9. Epub 2009 Aug 5.

Laboratory of Research on Biologically Compatible Compounds, Faculty of Dentistry, Rue Avicenne, 5019 Monastir, Tunisia.

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October 2009

Isothiocyanate from the Tunisian radish (Raphanus sativus) prevents genotoxicity of Zearalenone in vivo and in vitro.

Mutat Res 2009 Jun-Jul;677(1-2):59-65. Epub 2009 Jun 6.

Laboratory of Immunology, Environmental Microbiology and Cancerology, Faculty of Sciences Bizerte, 7021 Zarzouna, Tunisia.

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September 2009

Toxicities induced in cultured human hepatocarcinoma cells exposed to ochratoxin A: oxidative stress and apoptosis status.

J Biochem Mol Toxicol 2009 Mar-Apr;23(2):87-96

Laboratory of Research on Biologically Compatible Compounds, Faculty of Dentistry, Rue Avicenne, Monastir, 5000, Tunisia.

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July 2009

The antigenotoxic activities of cactus (Opuntia ficus-indica) cladodes against the mycotoxin zearalenone in Balb/c mice: prevention of micronuclei, chromosome aberrations and DNA fragmentation.

Food Chem Toxicol 2009 Mar 27;47(3):662-7. Epub 2008 Dec 27.

Research Unit of Macromolecular Biochemistry and Genetics, Faculty of Sciences of Gafsa, 2112 Gafsa, Tunisia.

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March 2009

Comparative mechanisms of zearalenone and ochratoxin A toxicities on cultured HepG2 cells: is oxidative stress a common process?

Environ Toxicol 2009 Dec;24(6):538-48

Laboratory of Research on Biologically Compatible Compounds, Faculty of Dentistry, Rue Avicenne, Monastir 5000, Tunisia.

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December 2009

Different apoptotic pathways induced by zearalenone, T-2 toxin and ochratoxin A in human hepatoma cells.

Toxicology 2008 Dec 10;254(1-2):19-28. Epub 2008 Sep 10.

Laboratory of Research on Biologically Compatible Compounds, Faculty of Dentistry, Rue Avicenne, Monastir 5000, Tunisia.

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December 2008

Cytotoxicity effects induced by Zearalenone metabolites, alpha Zearalenol and beta Zearalenol, on cultured Vero cells.

Toxicology 2008 Oct 8;252(1-3):72-7. Epub 2008 Aug 8.

Laboratoire de Recherche sur les Substances Biologiquement Compatibles (LRSBC), Faculté de Médecine Dentaire, Rue Avicenne, 5019 Monastir, Tunisia.

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October 2008

The mycotoxin Zearalenone induces apoptosis in human hepatocytes (HepG2) via p53-dependent mitochondrial signaling pathway.

Toxicol In Vitro 2008 Oct 10;22(7):1671-80. Epub 2008 Jul 10.

Laboratoire de Recherche sur les Substances Biologiquement Compatibles (LRSBC), Faculté de Médecine Dentaire, Rue Avicenne, 5019 Monastir, Tunisia.

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October 2008

Individual and combined effects of ochratoxin A and citrinin on viability and DNA fragmentation in cultured Vero cells and on chromosome aberrations in mice bone marrow cells.

Toxicology 2008 Sep 28;251(1-3):1-7. Epub 2008 Jun 28.

Laboratory of Research on Biologically Compatible Compounds, Faculty of Dentistry, Rue Avicenne, 5019 Monastir, Tunisia.

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September 2008

Cactus (Opuntia ficus-indica) cladodes prevent oxidative damage induced by the mycotoxin zearalenone in Balb/C mice.

Food Chem Toxicol 2008 May 21;46(5):1817-24. Epub 2008 Jan 21.

Research Unit of Macromolecular Biochemistry and Genetics, Faculty of Sciences of Gafsa, Gafsa, Tunisia.

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May 2008

Cytotoxicity and oxidative damage in kidney cells exposed to the mycotoxins ochratoxin a and citrinin: individual and combined effects.

Toxicol Mech Methods 2008 ;18(4):341-9

Laboratory for Research on Biologically Compatible Compounds, Faculty of Dentistry, Rue Avicenne, 5019 MonastirTunisia.

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October 2012

Heat shock proteins (Hsp 70) response is not systematic to cell stress: case of the mycotoxin ochratoxin A.

Toxicology 2007 Dec 19;242(1-3):63-70. Epub 2007 Sep 19.

Laboratory for Research on Biologically Compatible Compounds (LRSBC), Faculty of Dentistry, Rue Avicenne, 5000, Monastir, Tunisia.

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December 2007

Toxicities induced in cultured cells exposed to zearalenone: apoptosis or mutagenesis?

J Biochem Mol Toxicol 2007 ;21(3):136-44

Laboratory of Research on Biologically Compatible Compounds, Faculty of Dental Medicine, Monastir University, Rue Avicenne, 5019 Monastir, Tunisia.

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September 2007

The role of oxidative stress in zearalenone-mediated toxicity in Hep G2 cells: oxidative DNA damage, gluthatione depletion and stress proteins induction.

Toxicology 2007 Apr 30;232(3):294-302. Epub 2007 Jan 30.

Laboratory of Research on Biologically Compatible Compounds, Faculty of Dentistry, Rue Avicenne, 5019 Monastir, Tunisia.

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April 2007

Induction of Hsp 70 in Vero cells in response to mycotoxins cytoprotection by sub-lethal heat shock and by Vitamin E.

Toxicol Lett 2006 Oct 16;166(2):122-30. Epub 2006 Jun 16.

Laboratory of Research on Biologically Compatible Compounds, Faculty of Dentistry, Rue Avicenne, Monastir 5000, Tunisia.

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October 2006

Preventive role of phyllosilicate clay on the Immunological and Biochemical toxicity of zearalenone in Balb/c mice.

Int Immunopharmacol 2006 Aug 21;6(8):1251-8. Epub 2006 Apr 21.

Laboratory of Environmental Immunology Microbiology and Cancerology, Faculty of Sciences Bizerte, 7021 Zarzouna, Tunisia.

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August 2006

How much should we involve genetic and environmental factors in the risk assessment of mycotoxins in humans?

Int J Environ Res Public Health 2005 Apr;2(1):186-93

Dept of Toxicology, University of Bordeaux 2, 146, rue Lóo-Saignat, 33076 Bordeaux, France.

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April 2005

The protective effect of hydrated sodium calcium aluminosilicate against haematological, biochemical and pathological changes induced by Zearalenone in mice.

Toxicon 2006 Apr 24;47(5):567-74. Epub 2006 Mar 24.

Laboratory of Environmental Immunology, Microbiology and Cancerology, Faculty of Sciences Bizerte-7021-Zarzouna, Tunisia.

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April 2006

Cytotoxicity and Hsp 70 induction in Hep G2 cells in response to zearalenone and cytoprotection by sub-lethal heat shock.

Toxicology 2005 Feb;207(2):293-301

Laboratory of Research on Biologically Compatible Compounds, Faculty of Dentistry, Rue Avicenne, 5019 Monastir, Tunisia.

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February 2005

Ochratoxin A and beta2-microglobulinuria in healthy individuals and in chronic interstitial nephropathy patients in the centre of Tunisia: a hot spot of Ochratoxin A exposure.

Toxicology 2004 Jul;199(2-3):185-93

Laboratoire de Recherche sur les Substances Biologiquement Compatibles (LRSBC), Faculté de Médecine Dentaire, Rue Avicenne, 5019 Monastir, Tunisia.

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July 2004

DNA fragmentation, apoptosis and cell cycle arrest induced by zearalenone in cultured DOK, Vero and Caco-2 cells: prevention by Vitamin E.

Toxicology 2003 Nov;192(2-3):237-48

Laboratoire de Recherche sur les Substances Biologiquement Compatibles (LRSBC), Faculté de Médecine Dentaire, Rue Avicenne, 5019 Monastir, Tunisia.

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November 2003

Induction of micronuclei by Zearalenone in Vero monkey kidney cells and in bone marrow cells of mice: protective effect of Vitamin E.

Mutat Res 2003 Jul;538(1-2):63-70

Laboratoire de Recherche sur les Substances Biologiquement Compatibles (LRSBC), Faculté de Médecine Dentaire, Rue Avicenne, 5019 Monastir, Tunisia.

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July 2003

Ochratoxin A and human chronic nephropathy in Tunisia: is the situation endemic?

Hum Exp Toxicol 2003 Feb;22(2):77-84

Laboratoire de Recherche sur les Substances Biologiquement Compatibles, Faculté de Médecine Dentaire, Rue Avicenne, 5019 Monastir, Tunisia.

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February 2003