Harvey J Clewell

Harvey J Clewell

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Harvey J Clewell

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Extended Analysis and Evidence Integration of Chloroprene as a Human Carcinogen.

Risk Anal 2019 Sep 16. Epub 2019 Sep 16.

Cardno Chemrisk, Boston, MA, USA.

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http://dx.doi.org/10.1111/risa.13397DOI Listing
September 2019

A model of functional thyroid disease status over the lifetime.

PLoS One 2019 18;14(7):e0219769. Epub 2019 Jul 18.

Ramboll, Research Triangle Park, North Carolina, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0219769PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6638952PMC
July 2019

Dose-dependence of chemical carcinogenicity: Biological mechanisms for thresholds and implications for risk assessment.

Chem Biol Interact 2019 Mar 11;301:112-127. Epub 2019 Feb 11.

Ramboll US Corporation, Research Triangle Park, NC, USA.

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http://dx.doi.org/10.1016/j.cbi.2019.01.025DOI Listing
March 2019

Dose-response for assessing the cancer risk of inorganic arsenic in drinking water: the scientific basis for use of a threshold approach.

Crit Rev Toxicol 2019 Jan 1;49(1):36-84. Epub 2019 Apr 1.

Havlik-Wall Professor of Oncology, Department of Pathology and Microbiology and the Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center , Omaha , NE , USA.

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http://dx.doi.org/10.1080/10408444.2019.1573804DOI Listing
January 2019

Physiologically-based pharmacokinetic modeling suggests similar bioavailability of Mn from diet and drinking water.

Toxicol Appl Pharmacol 2018 11 20;359:70-81. Epub 2018 Sep 20.

ScitoVation, LLC., Research Triangle Park, NC, USA; ToxStrategies, Inc., Cary, NC, USA. Electronic address:

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http://dx.doi.org/10.1016/j.taap.2018.09.023DOI Listing
November 2018

High-throughput in-silico prediction of ionization equilibria for pharmacokinetic modeling.

Sci Total Environ 2018 Feb 29;615:150-160. Epub 2017 Sep 29.

National Center for Computational Toxicology, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, NC, USA.

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http://dx.doi.org/10.1016/j.scitotenv.2017.09.033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6055917PMC
February 2018

Refinement of the oral exposure description in the cyclic siloxane PBPK model for rats and humans: Implications for exposure assessment.

Toxicol Lett 2017 Oct 11;279 Suppl 1:125-135. Epub 2017 Apr 11.

ScitoVation, LLC, 6 Davis Drive, Research Triangle Park, NC 27709, United States.

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http://dx.doi.org/10.1016/j.toxlet.2017.04.002DOI Listing
October 2017

Quantitative bias analysis of a reported association between perfluoroalkyl substances (PFAS) and endometriosis: The influence of oral contraceptive use.

Environ Int 2017 07 6;104:118-121. Epub 2017 Apr 6.

Department of Occupational and Environmental Health, Université de Montréal, 2375 chemin de la Cote-Sainte-Catherine, Montreal, QC H3T 1A8, Canada; Universite de Montreal Public Health Research Institute (IRSPUM), Université de Montréal, 7101, Parc Ave., Montreal, QC H3N 1X7, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.envint.2017.03.023DOI Listing
July 2017

Determination of Human Hepatic CYP2C8 and CYP1A2 Age-Dependent Expression to Support Human Health Risk Assessment for Early Ages.

Drug Metab Dispos 2017 05 22;45(5):468-475. Epub 2017 Feb 22.

The Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina (G.S., X.S., H.J.C., M.Y.); ScitoVation, LLC, Research Triangle Park, North Carolina (G.S., X.S., H.J.C., M.Y.); U.S. Environmental Protection Agency, Research Triangle Park, North Carolina (R.N.H.); Medical College of Wisconsin, Milwaukee, Wisconsin (D.G.M.); Centre for Toxicology, University of Surrey, Surrey, United Kingdom (B.G.L.); Science Strategies, LLC, Charlottesville, Virginia (T.G.O.); and Valent USA Corporation, Walnut Creek, California (M.R.C.)

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http://dx.doi.org/10.1124/dmd.116.074583DOI Listing
May 2017

Modeling the effect of succimer (DMSA; dimercaptosuccinic acid) chelation therapy in patients poisoned by lead.

Clin Toxicol (Phila) 2017 Feb 5;55(2):133-141. Epub 2016 Dec 5.

b National Poisons Information Center, University Medical Center Utrecht , Utrecht , The Netherlands.

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http://dx.doi.org/10.1080/15563650.2016.1263855DOI Listing
February 2017

The application of PBPK models in estimating human brain tissue manganese concentrations.

Neurotoxicology 2017 01 15;58:226-237. Epub 2016 Dec 15.

ScitoVation, 6 Davis Drive, PO Box 110566, Research Triangle Park, NC 27709,United States.

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http://dx.doi.org/10.1016/j.neuro.2016.12.001DOI Listing
January 2017

Fluid Dynamic Modeling to Support the Development of Flow-Based Hepatocyte Culture Systems for Metabolism Studies.

Front Bioeng Biotechnol 2016 30;4:72. Epub 2016 Sep 30.

Institute for Chemical Safety Sciences, The Hamner Institutes for Health Sciences, Research Triangle Park, NC, USA; ScitoVation, LLC, Research Triangle Park, NC, USA.

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http://dx.doi.org/10.3389/fbioe.2016.00072DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5044513PMC
September 2016

PBPK Model for Atrazine and Its Chlorotriazine Metabolites in Rat and Human.

Toxicol Sci 2016 Apr 21;150(2):441-53. Epub 2016 Jan 21.

*The Hamner Institutes for Health Sciences, Center for Human Health Assessment, Research Triangle Park, North Carolina 27709-2137;

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http://dx.doi.org/10.1093/toxsci/kfw014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4809456PMC
April 2016

PBPK-Based Probabilistic Risk Assessment for Total Chlorotriazines in Drinking Water.

Toxicol Sci 2016 Apr 21;150(2):269-82. Epub 2016 Jan 21.

Sielken and Associates Consulting Inc, 1200 Beacon Court, College Station, Texas, 77845.

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http://dx.doi.org/10.1093/toxsci/kfw013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4809455PMC
April 2016

Development of an integrated multi-species and multi-dose route PBPK model for volatile methyl siloxanes - D4 and D5.

Regul Toxicol Pharmacol 2016 Feb 23;74 Suppl:S1-13. Epub 2015 Dec 23.

The Hamner Institutes for Health Sciences, 6 Davis Drive, P.O. Box 12137, Research Triangle Park, NC 27709-2137, USA. Electronic address:

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http://dx.doi.org/10.1016/j.yrtph.2015.12.010DOI Listing
February 2016

Evaluation of semi-generic PBTK modeling for emergency risk assessment after acute inhalation exposure to volatile hazardous chemicals.

Chemosphere 2015 Aug 17;132:47-55. Epub 2015 Mar 17.

National Poisons Information Center, University Medical Center Utrecht, Utrecht, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.chemosphere.2015.02.048DOI Listing
August 2015

Use of in vitro data in developing a physiologically based pharmacokinetic model: Carbaryl as a case study.

Toxicology 2015 Jun 24;332:52-66. Epub 2014 May 24.

Center for Human Health Assessment, The Hamner Institutes for Health Sciences, Research Triangle Park, NC, USA. Electronic address:

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http://dx.doi.org/10.1016/j.tox.2014.05.006DOI Listing
June 2015

Quantitative in vitro to in vivo extrapolation (QIVIVE): An essential element for in vitro-based risk assessment.

Toxicology 2015 Jun 11;332:1-3. Epub 2015 Feb 11.

The Hamner Institutes for Health Sciences, 6 Davis Drive, P.O. Box 12137, Research Triangle Park, NC 27709-2137, United States.

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http://dx.doi.org/10.1016/j.tox.2015.02.002DOI Listing
June 2015

A case study on quantitative in vitro to in vivo extrapolation for environmental esters: Methyl-, propyl- and butylparaben.

Toxicology 2015 Jun 31;332:67-76. Epub 2015 Mar 31.

The Hamner Institutes for Health Sciences, 6 Davis Drive, Research Triangle Park, NC 27709, USA.

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http://dx.doi.org/10.1016/j.tox.2015.03.010DOI Listing
June 2015

Molecular signaling network motifs provide a mechanistic basis for cellular threshold responses.

Environ Health Perspect 2014 Dec 12;122(12):1261-70. Epub 2014 Aug 12.

Institute for Chemical Safety Sciences, The Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina, USA.

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http://dx.doi.org/10.1289/ehp.1408244DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4256703PMC
December 2014

Incorporating population variability and susceptible subpopulations into dosimetry for high-throughput toxicity testing.

Toxicol Sci 2014 Nov 21;142(1):210-24. Epub 2014 Aug 21.

The Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina 27709-2137

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http://dx.doi.org/10.1093/toxsci/kfu169DOI Listing
November 2014

Development of 3D dynamic flow model of human liver and its application to prediction of metabolic clearance of 7-ethoxycoumarin.

Tissue Eng Part C Methods 2014 Aug 4;20(8):641-51. Epub 2014 Mar 4.

1 The Hamner Institutes for Health Sciences, Research Triangle Park , North Carolina.

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http://dx.doi.org/10.1089/ten.TEC.2013.0562DOI Listing
August 2014

The impact of recent advances in research on arsenic cancer risk assessment.

Regul Toxicol Pharmacol 2014 Jun 15;69(1):91-104. Epub 2014 Feb 15.

University of New Mexico, Albuquerque, NM 87131-00001, USA; ENVIRON International, 2200 Powell Street, Emeryville, CA 94608. Electronic address:

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http://dx.doi.org/10.1016/j.yrtph.2014.02.006DOI Listing
June 2014

Physiologically based pharmacokinetic (PBPK) modeling of interstrain variability in trichloroethylene metabolism in the mouse.

Environ Health Perspect 2014 May 11;122(5):456-63. Epub 2014 Feb 11.

National Center for Environmental Assessment, Office of Research and Development, U.S. Environmental Protection Agency, Washington, DC, USA.

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http://dx.doi.org/10.1289/ehp.1307623DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4014769PMC
May 2014

A hybrid CFD-PBPK model for naphthalene in rat and human with IVIVE for nasal tissue metabolism and cross-species dosimetry.

Inhal Toxicol 2014 May 25;26(6):333-44. Epub 2014 Mar 25.

Center for Human Health Assessment, The Hamner Institutes for Health Sciences , Research Triangle Park, NC , USA.

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http://dx.doi.org/10.3109/08958378.2014.896059DOI Listing
May 2014

Effects of endogenous formaldehyde in nasal tissues on inhaled formaldehyde dosimetry predictions in the rat, monkey, and human nasal passages.

Toxicol Sci 2014 Apr 2;138(2):412-24. Epub 2014 Jan 2.

Applied Research Associates, Inc., Raleigh, North Carolina 27615-2963.

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http://dx.doi.org/10.1093/toxsci/kft333DOI Listing
April 2014

Evaluation of simple in vitro to in vivo extrapolation approaches for environmental compounds.

Toxicol In Vitro 2014 Mar 8;28(2):164-70. Epub 2013 Nov 8.

The Hamner Institutes for Health Sciences, NC, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S08872333130027
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http://dx.doi.org/10.1016/j.tiv.2013.10.023DOI Listing
March 2014

Is the relationship between prenatal exposure to PCB-153 and decreased birth weight attributable to pharmacokinetics?

Environ Health Perspect 2013 Oct 9;121(10):1219-24. Epub 2013 Aug 9.

Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1289/ehp.1206457DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3801461PMC
October 2013

Evaluation of a predictive in vitro Leydig cell assay for anti-androgenicity of phthalate esters in the rat.

Toxicol In Vitro 2013 Sep 8;27(6):1711-8. Epub 2013 Apr 8.

The Hamner Institutes for Health Sciences, Research Triangle Park, NC 27709, USA.

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http://dx.doi.org/10.1016/j.tiv.2013.03.015DOI Listing
September 2013

In vitro intestinal and hepatic metabolism of Di(2-ethylhexyl) phthalate (DEHP) in human and rat.

Toxicol In Vitro 2013 Aug 29;27(5):1451-7. Epub 2013 Mar 29.

The Hamner Institutes for Health Sciences, RTP, NC 27709, United States.

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http://dx.doi.org/10.1016/j.tiv.2013.03.012DOI Listing
August 2013

Evaluation of gene expression changes in human primary uroepithelial cells following 24-hr exposures to inorganic arsenic and its methylated metabolites.

Environ Mol Mutagen 2013 Mar 29;54(2):82-98. Epub 2012 Nov 29.

Department of Internal Medicine, Division of Epidemiology, Biostatistics and Preventive Medicine, University of New Mexico, Albuquerque, New Mexico 87131-00001, USA.

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http://dx.doi.org/10.1002/em.21749DOI Listing
March 2013

Physiologically based pharmacokinetic/toxicokinetic modeling.

Methods Mol Biol 2012 ;929:439-99

The Hamner Institutes for Health Sciences, Research Triangle Park, NC, USA.

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http://dx.doi.org/10.1007/978-1-62703-050-2_18DOI Listing
February 2013

Deriving an explicit hepatic clearance equation accounting for plasma protein binding and hepatocellular uptake.

Toxicol In Vitro 2013 Feb 17;27(1):11-5. Epub 2012 Oct 17.

The Hamner Institutes for Health Sciences, Six Davis Drive, PO Box 12137, Research Triangle Park, NC 27709-2137, United States.

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http://dx.doi.org/10.1016/j.tiv.2012.10.003DOI Listing
February 2013

Cross-species transcriptomic analysis of mouse and rat lung exposed to chloroprene.

Toxicol Sci 2013 Feb 3;131(2):629-40. Epub 2012 Nov 3.

The Hamner Institutes for Health Sciences, Research Triangle Park, NC 27709, USA.

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http://dx.doi.org/10.1093/toxsci/kfs314DOI Listing
February 2013

Development of PBPK models for PFOA and PFOS for human pregnancy and lactation life stages.

J Toxicol Environ Health A 2013 ;76(1):25-57

Center for Human Health Assessment, The Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina, USA.

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http://dx.doi.org/10.1080/15287394.2012.722523DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3502013PMC
January 2013

Application of a multi-route physiologically based pharmacokinetic model for manganese to evaluate dose-dependent neurological effects in monkeys.

Toxicol Sci 2012 Oct 21;129(2):432-46. Epub 2012 Jun 21.

The Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina, USA.

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http://dx.doi.org/10.1093/toxsci/kfs212DOI Listing
October 2012

In vitro to in vivo extrapolation and species response comparisons for drug-induced liver injury (DILI) using DILIsym™: a mechanistic, mathematical model of DILI.

J Pharmacokinet Pharmacodyn 2012 Oct 9;39(5):527-41. Epub 2012 Aug 9.

The Hamner-UNC Institute for Drug Safety Sciences, The Hamner Institutes, Durham, NC 27709, USA.

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http://dx.doi.org/10.1007/s10928-012-9266-0DOI Listing
October 2012

Kinetic modeling of β-chloroprene metabolism: Probabilistic in vitro-in vivo extrapolation of metabolism in the lung, liver and kidneys of mice, rats and humans.

Toxicol In Vitro 2012 Sep 19;26(6):1047-55. Epub 2012 Apr 19.

Center for Human Health Assessment, The Hamner Institutes for Health Sciences, Research Triangle Park, NC, USA.

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http://dx.doi.org/10.1016/j.tiv.2012.04.004DOI Listing
September 2012

Quantitative in vitro to in vivo extrapolation of cell-based toxicity assay results.

Crit Rev Toxicol 2012 Sep 6;42(8):633-52. Epub 2012 Jun 6.

Center for Human Health Assessment, The Hamner Institutes for Health Sciences, Research Triangle Park, Durham, NC 27709, USA.

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http://dx.doi.org/10.3109/10408444.2012.692115DOI Listing
September 2012

Development of multi-route physiologically-based pharmacokinetic models for ethanol in the adult, pregnant, and neonatal rat.

Inhal Toxicol 2012 Sep;24(11):698-722

Neurotoxicology Branch, Toxicity Assessment Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, US Environmental Protection Agency Research Triangle Park, NC 27711, USA.

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http://www.tandfonline.com/doi/full/10.3109/08958378.2012.71
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http://dx.doi.org/10.3109/08958378.2012.712165DOI Listing
September 2012

Integrating pathway-based transcriptomic data into quantitative chemical risk assessment: a five chemical case study.

Mutat Res 2012 Aug 25;746(2):135-43. Epub 2012 Jan 25.

The Hamner Institutes for Health Sciences, Research Triangle Park, NC 27709, USA.

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http://dx.doi.org/10.1016/j.mrgentox.2012.01.007DOI Listing
August 2012

An analysis of N-acetylcysteine treatment for acetaminophen overdose using a systems model of drug-induced liver injury.

J Pharmacol Exp Ther 2012 Aug 16;342(2):529-40. Epub 2012 May 16.

The Hamner-University of North Carolina Institute for Drug Safety Sciences, The Hamner Institutes, Research Triangle Park, North Carolina, USA.

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http://jpet.aspetjournals.org/content/early/2012/05/16/jpet.
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http://jpet.aspetjournals.org/content/342/2/529.full.pdf
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http://jpet.aspetjournals.org/cgi/doi/10.1124/jpet.112.19293
Publisher Site
http://dx.doi.org/10.1124/jpet.112.192930DOI Listing
August 2012

Comparison and evaluation of pharmacokinetics of PFOA and PFOS in the adult rat using a physiologically based pharmacokinetic model.

Reprod Toxicol 2012 Jul 4;33(4):452-467. Epub 2011 May 4.

Center for Human Health Assessment, The Hamner Institutes for Health Sciences, 6 Davis Drive, P.O. Box 12137, Research Triangle Park, NC 27709, United States.

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https://linkinghub.elsevier.com/retrieve/pii/S08906238110014
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http://dx.doi.org/10.1016/j.reprotox.2011.04.006DOI Listing
July 2012

Evaluation of placental and lactational pharmacokinetics of PFOA and PFOS in the pregnant, lactating, fetal and neonatal rat using a physiologically based pharmacokinetic model.

Reprod Toxicol 2012 Jul 18;33(4):468-490. Epub 2011 Aug 18.

Center for Human Health Assessment, The Hamner Institutes for Health Sciences, 6 Davis Drive, P.O. Box 12137, Research Triangle Park, NC 27709, United States.

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http://linkinghub.elsevier.com/retrieve/pii/S089062381100345
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http://dx.doi.org/10.1016/j.reprotox.2011.07.003DOI Listing
July 2012

Physiologically based pharmacokinetic model use in risk assessment--Why being published is not enough.

Toxicol Sci 2012 Mar 1;126(1):5-15. Epub 2011 Nov 1.

National Center for Environmental Assessment, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA.

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http://dx.doi.org/10.1093/toxsci/kfr295DOI Listing
March 2012

In vitro metabolism of di(2-ethylhexyl) phthalate (DEHP) by various tissues and cytochrome P450s of human and rat.

Toxicol In Vitro 2012 Mar 13;26(2):315-22. Epub 2011 Dec 13.

The Hamner Institutes for Health Sciences, Research Triangle Park, NC 27709, United States.

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http://dx.doi.org/10.1016/j.tiv.2011.12.002DOI Listing
March 2012

Can case study approaches speed implementation of the NRC report: "toxicity testing in the 21st century: a vision and a strategy?".

ALTEX 2011 ;28(3):175-82

The Institute for Chemical Safety Sciences, The Hamner Institutes for Health Sciences, Research Triangle Park, NC 27709-2137, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3943477PMC
February 2012

A semiphysiologically based pharmacokinetic modeling approach to predict the dose-exposure relationship of an antiparasitic prodrug/active metabolite pair.

Drug Metab Dispos 2012 Jan 27;40(1):6-17. Epub 2011 Sep 27.

Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7569, USA.

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http://dx.doi.org/10.1124/dmd.111.040063DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3250045PMC
January 2012

Physiologically based pharmacokinetic modeling of fetal and neonatal manganese exposure in humans: describing manganese homeostasis during development.

Toxicol Sci 2011 Aug 27;122(2):297-316. Epub 2011 May 27.

Center for Human Health Assessment, The Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina 27709, USA.

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http://dx.doi.org/10.1093/toxsci/kfr141DOI Listing
August 2011

Analysis of manganese tracer kinetics and target tissue dosimetry in monkeys and humans with multi-route physiologically based pharmacokinetic models.

Toxicol Sci 2011 Apr 27;120(2):481-98. Epub 2010 Dec 27.

The Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina 27709-2137, USA.

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http://dx.doi.org/10.1093/toxsci/kfq389DOI Listing
April 2011

p53 codon 271 CGT to CAT mutant fraction does not increase in nasal respiratory and olfactory epithelia of rats exposed to inhaled naphthalene.

Mutat Res 2011 Apr 13;721(2):199-205. Epub 2011 Feb 13.

National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, USA.

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http://dx.doi.org/10.1016/j.mrgentox.2011.02.004DOI Listing
April 2011

Application of transcriptional benchmark dose values in quantitative cancer and noncancer risk assessment.

Toxicol Sci 2011 Mar 22;120(1):194-205. Epub 2010 Nov 22.

The Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina 27709, USA.

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http://dx.doi.org/10.1093/toxsci/kfq355DOI Listing
March 2011

Evaluation and prediction of pharmacokinetics of PFOA and PFOS in the monkey and human using a PBPK model.

Regul Toxicol Pharmacol 2011 Feb;59(1):157-75

Center for Human Health Assessment, Hamner Institutes for Health Sciences, 6 Davis Drive, P.O. Box 12137, Research Triangle Park, NC 27709, United States.

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http://dx.doi.org/10.1016/j.yrtph.2010.12.004DOI Listing
February 2011

PBPK modelling of inter-individual variability in the pharmacokinetics of environmental chemicals.

Toxicology 2010 Dec 30;278(3):256-67. Epub 2010 Jun 30.

UTC, Technological University of Compiegne, Chair of Mathematical Modelling for Systems Toxicology, Royallieu Research Centre, BP 20529, 60205 Compiegne Cedex, France.

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http://dx.doi.org/10.1016/j.tox.2010.06.007DOI Listing
December 2010

Formaldehyde: integrating dosimetry, cytotoxicity, and genomics to understand dose-dependent transitions for an endogenous compound.

Toxicol Sci 2010 Dec 30;118(2):716-31. Epub 2010 Sep 30.

Program in Chemical Safety Sciences, The Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina 27709, USA.

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http://dx.doi.org/10.1093/toxsci/kfq303DOI Listing
December 2010

Incorporating human dosimetry and exposure into high-throughput in vitro toxicity screening.

Toxicol Sci 2010 Oct 16;117(2):348-58. Epub 2010 Jul 16.

National Center for Computational Toxicology, Office of Research and Development, United States Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA.

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http://dx.doi.org/10.1093/toxsci/kfq220DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6280841PMC
October 2010

Genome-wide analysis of DNA methylation and gene expression changes in the mouse lung following subchronic arsenate exposure.

Toxicol Sci 2010 Oct 28;117(2):404-17. Epub 2010 Jul 28.

The Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina 27709, USA.

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http://dx.doi.org/10.1093/toxsci/kfq225DOI Listing
October 2010

Measurement of tumor-associated mutations in the nasal mucosa of rats exposed to varying doses of formaldehyde.

Regul Toxicol Pharmacol 2010 Jul-Aug;57(2-3):274-83. Epub 2010 Mar 27.

US Food and Drug Administration, National Center for Toxicological Research, Division of Genetic and Reproductive Toxicology, Jefferson, AR 72079, USA.

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http://dx.doi.org/10.1016/j.yrtph.2010.03.007DOI Listing
September 2010

Bayesian analysis of a rat formaldehyde DNA-protein cross-link model.

J Toxicol Environ Health A 2010 ;73(12):787-806

The Hamner Institutes for Health Sciences, Center for Human Health Assessment, Research Triangle Park, North Carolina 27711, USA.

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http://dx.doi.org/10.1080/15287391003689234DOI Listing
April 2010

Multi-dose-route, multi-species pharmacokinetic models for manganese and their use in risk assessment.

J Toxicol Environ Health A 2010 ;73(2):217-34

The Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina 27709-2137, USA.

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http://dx.doi.org/10.1080/15287390903340849DOI Listing
February 2010

Lactational transfer of manganese in rats: predicting manganese tissue concentration in the dam and pups from inhalation exposure with a pharmacokinetic model.

Toxicol Sci 2009 Nov 2;112(1):23-43. Epub 2009 Sep 2.

Center for Human Health Assessment, The Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina 27709, USA.

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http://dx.doi.org/10.1093/toxsci/kfp197DOI Listing
November 2009

Evaluating placental transfer and tissue concentrations of manganese in the pregnant rat and fetuses after inhalation exposures with a PBPK model.

Toxicol Sci 2009 Nov 2;112(1):44-58. Epub 2009 Sep 2.

The Hamner Institutes for Health Sciences, 6 Davis Drive, Research Triangle Park, North Carolina 27709, USA.

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http://dx.doi.org/10.1093/toxsci/kfp198DOI Listing
November 2009

Manganese tissue dosimetry in rats and monkeys: accounting for dietary and inhaled Mn with physiologically based pharmacokinetic modeling.

Toxicol Sci 2009 Mar 19;108(1):22-34. Epub 2008 Dec 19.

The Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina 27709, USA.

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http://dx.doi.org/10.1093/toxsci/kfn264DOI Listing
March 2009

How can biologically-based modeling of arsenic kinetics and dynamics inform the risk assessment process? - A workshop review.

Toxicol Appl Pharmacol 2008 Nov 15;232(3):359-68. Epub 2008 Jul 15.

Experimental Toxicology Division, B143-01 National Health and Environmental Effects Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, NC 27711, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S0041008X0800286
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http://dx.doi.org/10.1016/j.taap.2008.06.023DOI Listing
November 2008

Bayesian calibration of a physiologically based pharmacokinetic/pharmacodynamic model of carbaryl cholinesterase inhibition.

J Toxicol Environ Health A 2008 ;71(20):1363-81

The Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina 27709, USA.

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http://dx.doi.org/10.1080/15287390802271608DOI Listing
August 2008

Hormesis and adaptive cellular control systems.

Dose Response 2008 Mar 19;6(2):196-208. Epub 2008 Mar 19.

Division of Computational Biology, The Hamner Institutes for Health Sciences, 6 Davis Drive, Research Triangle Park, NC 27709, USA.

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http://dx.doi.org/10.2203/dose-response.07-028.ZhangDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2478522PMC
March 2008