Haruki Hasegawa, PhD - Amgen Inc. - Principal Scientist

Haruki Hasegawa

PhD

Amgen Inc.

Principal Scientist

South San Francisco, CA | United States

Main Specialties: Biology

Additional Specialties: Protein trafficking Protein biosynthesis

ORCID logohttps://orcid.org/0000-0002-3464-4715

Haruki Hasegawa, PhD - Amgen Inc. - Principal Scientist

Haruki Hasegawa

PhD

Introduction

Primary Affiliation: Amgen Inc. - South San Francisco, CA , United States

Specialties:

Additional Specialties:

Education

Jan 1995 - Jan 1997
Ball State University
MA
Biology
University of Michigan
PhD
Molecular Cellular and Developmental Biology
National Institutes of Health
Post doctoral
Cell Biology and Intracellular Protein Trafficking

Experience

Jan 2004 - Jan 2005
National Institutes of Health
Postdoctoral Research Fellow
Cell Biology and Metabolism - Intracellular Protein Trafficking
Jan 2001 - Jan 2004
University of Michigan
Instructor & Research Assistant
Molecular Cellular Biology
Jan 1997 - Jan 2001
Bayer Yakuhin Ltd
Scientist
Assay Development for HTS
Jan 2005
Amgen Inc San Francisco
Principal Scientist
Therapeutic Discovery - Biologics

Publications

17Publications

262Reads

1255Profile Views

144PubMed Central Citations

Simultaneous induction of distinct protein phase separation events in multiple subcellular compartments of a single cell.

Authors:
Haruki Hasegawa

Exp Cell Res 2019 Mar 6. Epub 2019 Mar 6.

Department of Therapeutic Discovery, Amgen Inc., South San Francisco, CA 94080, USA. Electronic address:

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http://dx.doi.org/10.1016/j.yexcr.2019.03.010DOI Listing
March 2019
2 Reads
3.246 Impact Factor

Membrane cholesterol modulates STEAP2 conformation during dynamic intracellular trafficking processes leading to broad subcellular distribution.

Exp Cell Res 2018 Sep 27;370(2):208-226. Epub 2018 Jun 27.

Department of Therapeutic Discovery, Amgen Inc., South San Francisco, CA 94080, USA.

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http://dx.doi.org/10.1016/j.yexcr.2018.06.022DOI Listing
September 2018
13 Reads
3.250 Impact Factor

Topogenesis and cell surface trafficking of GPR34 are facilitated by positive-inside rule that effects through a tri-basic motif in the first intracellular loop.

Biochim Biophys Acta 2016 Jul 14;1863(7 Pt A):1534-51. Epub 2016 Apr 14.

Department of Therapeutic Discovery, Amgen Inc., South San Francisco, CA 94080, USA.

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http://dx.doi.org/10.1016/j.bbamcr.2016.04.010DOI Listing
July 2016
12 Reads
2 Citations

Overexpression of cryoglobulin-like single-chain antibody induces morular cell phenotype via liquid-liquid phase separation in the secretory pathway organelles.

FEBS J 2015 Aug 19;282(15):2777-95. Epub 2015 Jun 19.

Department of Therapeutic Discovery, Amgen Inc., South San Francisco, CA, USA.

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http://dx.doi.org/10.1111/febs.13332DOI Listing
August 2015
8 Reads
2 Citations
4.001 Impact Factor

Modulation of in vivo IgG crystallization in the secretory pathway by heavy chain isotype class switching and N-linked glycosylation.

Biochim Biophys Acta 2014 Jul 2;1843(7):1325-38. Epub 2014 Apr 2.

Department of Therapeutic Discovery, Amgen Inc., 1201 Amgen Court West, Seattle, WA 98119, USA.

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http://dx.doi.org/10.1016/j.bbamcr.2014.03.024DOI Listing
July 2014
11 Reads
4 Citations

Aggregates, crystals, gels, and amyloids: intracellular and extracellular phenotypes at the crossroads of immunoglobulin physicochemical property and cell physiology.

Authors:
Haruki Hasegawa

Int J Cell Biol 2013 5;2013:604867. Epub 2013 Mar 5.

Department of Therapeutic Discovery, Amgen Inc., 1201 Amgen Court West, Seattle, WA 98119, USA.

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http://dx.doi.org/10.1155/2013/604867DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3603282PMC
March 2013
3 Reads
6 Citations

Russell body inducing threshold depends on the variable domain sequences of individual human IgG clones and the cellular protein homeostasis.

Biochim Biophys Acta 2012 Oct 20;1823(10):1643-57. Epub 2012 Jun 20.

Department of Therapeutic Discovery, Amgen Inc., Seattle, WA 98119, USA.

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http://dx.doi.org/10.1016/j.bbamcr.2012.06.015DOI Listing
October 2012
3 Reads
7 Citations

R-SNARE ykt6 resides in membrane-associated protease-resistant protein particles and modulates cell cycle progression when over-expressed.

Biol Cell 2012 Jul 29;104(7):397-417. Epub 2012 May 29.

Division of Biological Sciences and Centre for Structural and Functional Neuroscience, The University of Montana, Missoula, MT 59812, USA.

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http://dx.doi.org/10.1111/boc.201100048DOI Listing
July 2012
10 Reads
4 Citations
3.510 Impact Factor

Diverse functions of reactive cysteines facilitate unique biosynthetic processes of aggregate-prone interleukin-31.

Exp Cell Res 2011 Apr 21;317(7):976-93. Epub 2010 Dec 21.

Department of Protein Science, Amgen Inc, Seattle, WA 98119, USA.

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http://dx.doi.org/10.1016/j.yexcr.2010.12.012DOI Listing
April 2011
5 Reads
3.250 Impact Factor

Native IL-32 is released from intestinal epithelial cells via a non-classical secretory pathway as a membrane-associated protein.

Cytokine 2011 Jan;53(1):74-83

Department of Protein Science, Amgen Inc., 1201 Amgen Court West, Seattle, WA 98119, USA.

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http://dx.doi.org/10.1016/j.cyto.2010.09.002DOI Listing
January 2011
2 Reads
17 Citations
2.664 Impact Factor

Intramolecular protein-protein and protein-lipid interactions control the conformation and subcellular targeting of neuronal Ykt6.

J Cell Sci 2004 Sep;117(Pt 19):4495-508

University of Michigan, Department of Molecular, Cellular and Developmental Biology, Ann Arbor, MI 48109-1048, USA.

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http://dx.doi.org/10.1242/jcs.01314DOI Listing
September 2004
4 Reads
15 Citations
5.432 Impact Factor

Development of a high-throughput fluoroimmunoassay for Syk kinase and Syk kinase inhibitors.

Anal Biochem 2003 Apr;315(2):256-61

Research Center Kyoto, Bayer Yakuhin, Ltd, 6-5-1-3, Kunimidai, Kizu-cho, Soraku-gun, Kyoto 619-0216, Japan.

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April 2003
7 Reads
6 Citations
2.220 Impact Factor

Mammalian ykt6 is a neuronal SNARE targeted to a specialized compartment by its profilin-like amino terminal domain.

Mol Biol Cell 2003 Feb;14(2):698-720

University of Michigan, Department of Molecular, Cellular, and Developmental Biology, Ann Arbor 48109-1048, USA.

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http://dx.doi.org/10.1091/mbc.e02-09-0556DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC150002PMC
February 2003
9 Reads
30 Citations
4.470 Impact Factor

Top co-authors

Min Shen
Min Shen

National Center for Advancing Translational Sciences

4
Jesse C Hay
Jesse C Hay

The University of Montana

3
Neha Patel
Neha Patel

Department of Otolaryngology

3
Feng He
Feng He

Ocean University of China

2
Francis Kinderman
Francis Kinderman

University of California

2
Christopher Mehlin
Christopher Mehlin

University of Washington

2
Svend Davanger
Svend Davanger

Institute of Basic Medical Science

2