Hartmut Weiler

Hartmut Weiler

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Hartmut Weiler

Hartmut Weiler

Publications by authors named "Hartmut Weiler"

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Role of Thrombomodulin expression on hematopoietic stem cells.

J Thromb Haemost 2019 Oct 19. Epub 2019 Oct 19.

Blood Research Institute, BloodCenter of Wisconsin: part of Versiti, Milwaukee, WI, USA.

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http://dx.doi.org/10.1111/jth.14663DOI Listing
October 2019

Myeloid cell-synthesized coagulation factor X dampens antitumor immunity.

Sci Immunol 2019 Sep;4(39)

Center for Thrombosis and Hemostasis, Johannes Gutenberg University Medical Center, Mainz, Germany.

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http://dx.doi.org/10.1126/sciimmunol.aaw8405DOI Listing
September 2019

TGF-β1 along with other platelet contents augments Treg cells to suppress anti-FVIII immune responses in hemophilia A mice.

Blood Adv 2016 Dec;1(2):139-151

Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI; Children's Research Institute, Children's Hospital of Wisconsin, Milwaukee, WI; Midwest Athletes Against Childhood Cancer Fund Research Center, Milwaukee, WI; Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, WI.

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http://www.bloodadvances.org/lookup/doi/10.1182/bloodadvance
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http://dx.doi.org/10.1182/bloodadvances.2016001453DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5288643PMC
December 2016

High endogenous activated protein C levels attenuates bleomycin-induced pulmonary fibrosis.

J Cell Mol Med 2016 11 14;20(11):2029-2035. Epub 2016 Jun 14.

Center for Experimental and Molecular Medicine, Academic Medical Center, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1111/jcmm.12891DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5082406PMC
November 2016

Nogo-B receptor deficiency causes cerebral vasculature defects during embryonic development in mice.

Dev Biol 2016 Feb 31;410(2):190-201. Epub 2015 Dec 31.

Division of Pediatric Surgery, Department of Surgery, Medical College of Wisconsin, Milwaukee, WI 53226, USA; Division of Pediatric Pathology, Department of Pathology, Medical College of Wisconsin, Milwaukee, WI 53226, USA; Children's Research Institute, Medical College of Wisconsin, Milwaukee, WI 53226, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ydbio.2015.12.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4767500PMC
February 2016

Thrombomodulin contributes to gamma tocotrienol-mediated lethality protection and hematopoietic cell recovery in irradiated mice.

PLoS One 2015 10;10(4):e0122511. Epub 2015 Apr 10.

Division of Radiation Health, Department of Pharmaceutical Sciences, College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, AR, United States of America; Surgical Service, Central Arkansas Veterans Healthcare System, Little Rock, AR, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0122511PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4393275PMC
December 2015

A balance between TFPI and thrombin-mediated platelet activation is required for murine embryonic development.

Blood 2015 Jun 7;125(26):4078-84. Epub 2015 May 7.

Blood Research Institute, Blood Center of Wisconsin, Milwaukee, WI; Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, WI.

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http://dx.doi.org/10.1182/blood-2015-03-633958DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4481595PMC
June 2015

Intraperitoneal administration of activated protein C prevents postsurgical adhesion band formation.

Blood 2015 Feb 9;125(8):1339-48. Epub 2015 Jan 9.

Department of Biochemistry and Molecular Biology, St. Louis University School of Medicine, Saint Louis, MO; and.

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http://dx.doi.org/10.1182/blood-2014-10-609339DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4335085PMC
February 2015

Sucrose non-fermenting related kinase enzyme is essential for cardiac metabolism.

Biol Open 2014 Dec 12;4(1):48-61. Epub 2014 Dec 12.

Department of Pediatrics, Developmental Vascular Biology Program, Children's Research Institute, Medical College of Wisconsin, Milwaukee, WI 53226, USA Department of Obstetrics and Gynecology, Medical College of Wisconsin, Milwaukee, WI 53226, USA

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http://dx.doi.org/10.1242/bio.20149811DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4295165PMC
December 2014

A conditional knockout mouse model reveals endothelial cells as the principal and possibly exclusive source of plasma factor VIII.

Blood 2014 Jun 4;123(24):3706-13. Epub 2014 Apr 4.

Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, WI; Medical College of Wisconsin, Milwaukee, WI; and Children's Research Institute, Children's Hospital of Wisconsin, Milwaukee, WI.

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http://dx.doi.org/10.1182/blood-2014-02-555151DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4055921PMC
June 2014

Inflammation-associated activation of coagulation and immune regulation by the protein C pathway.

Authors:
Hartmut Weiler

Thromb Res 2014 May;133 Suppl 1:S32-4

Blood Research Institute, BloodCenter of Wisconsin, Milwaukee WI, USA; Department of Physiology, Medical College of Wisconsin, Milwaukee WI, USA. Electronic address:

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http://dx.doi.org/10.1016/j.thromres.2014.03.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4060429PMC
May 2014

A thrombomodulin mutation that impairs active protein C generation is detrimental in severe pneumonia-derived gram-negative sepsis (melioidosis).

PLoS Negl Trop Dis 2014 Apr 24;8(4):e2819. Epub 2014 Apr 24.

Center for Experimental and Molecular Medicine, Academic Medical Center-University of Amsterdam, Amsterdam, The Netherlands; Center for Infection and Immunity Amsterdam (CINIMA), Academic Medical Center-University of Amsterdam, Amsterdam, The Netherlands; Division of Infectious Diseases, Academic Medical Center-University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1371/journal.pntd.0002819DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3998929PMC
April 2014

Thrombomodulin regulates keratinocyte differentiation and promotes wound healing.

J Invest Dermatol 2013 Jun 15;133(6):1638-45. Epub 2013 Jan 15.

Department of Biochemistry and Molecular Biology, College of Medicine, National Cheng Kung University, Tainan, Taiwan, Republic of China.

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http://dx.doi.org/10.1038/jid.2013.8DOI Listing
June 2013

Thrombomodulin is required for the antithrombotic activity of thrombin mutant W215A/E217A in a mouse model of arterial thrombosis.

Thromb Res 2012 Oct 16;130(4):646-8. Epub 2011 Dec 16.

Department of Anatomy, Cellular Biology, Physiology and Biophysics, Institute of Biology, State University of Campinas (UNICAMP), São Paulo, Brazil.

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http://dx.doi.org/10.1016/j.thromres.2011.11.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3461961PMC
October 2012

Critical role for Gimap5 in the survival of mouse hematopoietic stem and progenitor cells.

J Exp Med 2011 May 18;208(5):923-35. Epub 2011 Apr 18.

Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, WI 53226, USA.

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http://dx.doi.org/10.1084/jem.20101192DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3092340PMC
May 2011

Factor V Leiden mutation enhances fibrin formation and dissolution in vivo in a human endotoxemia model.

Blood 2010 Aug 21;116(5):801-5. Epub 2010 Apr 21.

Department of Medicine I, University Medical Center Mannheim, Mannheim, Germany.

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http://dx.doi.org/10.1182/blood-2009-03-213215DOI Listing
August 2010

Regulation of inflammation by the protein C system.

Authors:
Hartmut Weiler

Crit Care Med 2010 Feb;38(2 Suppl):S18-25

Blood Research Institute, Blood Center of Wisconsin, Milwaukee, WI, USA.

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http://dx.doi.org/10.1097/CCM.0b013e3181c9cbb5DOI Listing
February 2010

Fibrinogen alpha and gamma genes and factor VLeiden in children with thromboembolism: results from 2 family-based association studies.

Blood 2009 Aug 10;114(9):1947-53. Epub 2009 Jun 10.

Pediatric Hematology/Oncology, University of Muenster, Muenster, Germany.

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http://dx.doi.org/10.1182/blood-2009-04-218727DOI Listing
August 2009

Caveolin-1-dependent apoptosis induced by fibrin degradation products.

Blood 2009 Apr 12;113(18):4431-9. Epub 2008 Dec 12.

Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, WI 53226-3548, USA.

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http://dx.doi.org/10.1182/blood-2008-07-169433DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2676096PMC
April 2009

Endogenous EPCR/aPC-PAR1 signaling prevents inflammation-induced vascular leakage and lethality.

Blood 2009 Mar 13;113(12):2859-66. Epub 2009 Jan 13.

Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1182/blood-2008-12-192385DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2661868PMC
March 2009

Tracing the molecular pathogenesis of antiphospholipid syndrome.

Authors:
Hartmut Weiler

J Clin Invest 2008 Oct;118(10):3276-8

Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, Wisconsin, USA.

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http://dx.doi.org/10.1172/JCI37243DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2542859PMC
October 2008

Activated protein C in sepsis: the promise of nonanticoagulant activated protein C.

Curr Opin Hematol 2008 Sep;15(5):487-93

aBlood Research Institute, BloodCenter of Wisconsin, Milwaukee, Wisconsin, USA.

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http://dx.doi.org/10.1097/MOH.0b013e32830abdf4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2742321PMC
September 2008

Maternal Par4 and platelets contribute to defective placenta formation in mouse embryos lacking thrombomodulin.

Blood 2008 Aug 19;112(3):585-91. Epub 2008 May 19.

Blood Research Institute, Blood Center of Wisconsin, Milwaukee, Wisconsin 53226, USA.

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http://dx.doi.org/10.1182/blood-2007-09-111302DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2481555PMC
August 2008

Factor VIII ectopically targeted to platelets is therapeutic in hemophilia A with high-titer inhibitory antibodies.

J Clin Invest 2006 Jul;116(7):1974-82

Blood Research Institute, BloodCenter of Wisconsin, Department of Pediatrics, Medical College of Wisconsin, and Children's Research Institute, Children's Hospital of Wisconsin, Milwaukee, Wisconsin 53226, USA.

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http://dx.doi.org/10.1172/JCI28416DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1483176PMC
July 2006

Myospryn is a direct transcriptional target for MEF2A that encodes a striated muscle, alpha-actinin-interacting, costamere-localized protein.

J Biol Chem 2006 Mar 3;281(10):6841-9. Epub 2006 Jan 3.

Department of Biology, Program in Cell and Molecular Biology, Boston University, Boston, Massachusetts 02215, USA.

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http://dx.doi.org/10.1074/jbc.M510499200DOI Listing
March 2006

Restricted inactivation of serum response factor to the cardiovascular system.

Proc Natl Acad Sci U S A 2004 Dec 29;101(49):17132-7. Epub 2004 Nov 29.

Center for Cardiovascular Research, Aab Institute of Biomedical Sciences, University of Rochester, 601 Elmwood Avenue, Rochester, NY 14642, USA.

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http://dx.doi.org/10.1073/pnas.0406041101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC535359PMC
December 2004

Mouse models of thrombosis: thrombomodulin.

Authors:
Hartmut Weiler

Thromb Haemost 2004 Sep;92(3):467-77

Blood Research Institute, Blood Center of Southeastern Wisconsin, Medical College of Wisconsin, Department of Physiology, 8727 Watertown Plank Road, Milwaukee, WI 53226, USA.

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http://dx.doi.org/10.1160/TH04-05-0307DOI Listing
September 2004

Factor V Leiden polymorphism modifies sepsis outcome: evidence from animal studies.

Crit Care Med 2004 May;32(5 Suppl):S233-8

Blood Research Institute, Blood Center of Southeastern Wisconsin, Milwaukee, WI, USA.

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http://dx.doi.org/10.1097/01.ccm.0000126126.79861.08DOI Listing
May 2004

Survival advantage associated with heterozygous factor V Leiden mutation in patients with severe sepsis and in mouse endotoxemia.

Blood 2003 Nov 17;102(9):3085-92. Epub 2003 Jul 17.

Blood Research Institute, Blood Center of Southeast Wisconsin and Medical College of Wisconsin, Milwaukee, WI 53226, USA.

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http://dx.doi.org/10.1182/blood-2003-06-1789DOI Listing
November 2003

Embryogenesis and gene targeting of coagulation factors in mice.

Best Pract Res Clin Haematol 2003 Jun;16(2):169-81

Blood Research Institute, The Blood Center of Southeastern Wisconsin, Milwaukee, WI 53226, USA.

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June 2003

The thrombomodulin-protein C system is essential for the maintenance of pregnancy.

Nat Med 2003 Mar 10;9(3):331-7. Epub 2003 Feb 10.

Blood Research Institute, The Blood Center of Southeastern Wisconsin, Milwaukee, Wisconsin, USA.

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http://dx.doi.org/10.1038/nm825DOI Listing
March 2003

Expression of human smooth muscle calponin in transgenic mice revealed with a bacterial artificial chromosome.

Am J Physiol Heart Circ Physiol 2002 May;282(5):H1793-803

Center for Cardiovascular Research, University of Rochester Medical Center, Rochester, New York 14642, USA.

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http://dx.doi.org/10.1152/ajpheart.00875.2001DOI Listing
May 2002