Publications by authors named "Hartmut Ruetten"

40Publications

Type-2 diabetes-associated variants with cross-trait relevance: Post-GWAs strategies for biological function interpretation.

Mol Genet Metab 2017 05 22;121(1):43-50. Epub 2017 Mar 22.

Department of Translational Informatics, R&D Translational Med. and Early Development, Sanofi-Aventis, Deutschland GmbH, Industriepark Höchst, D-65926 Frankfurt am Main, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.ymgme.2017.03.004DOI Listing
May 2017

Inhibition of citrate cotransporter Slc13a5/mINDY by RNAi improves hepatic insulin sensitivity and prevents diet-induced non-alcoholic fatty liver disease in mice.

Mol Metab 2016 11 13;5(11):1072-1082. Epub 2016 Aug 13.

Department of Endocrinology, Diabetes and Nutrition, Center for Cardiovascular Research, Charité - University School of Medicine, Berlin, 10117, Germany; DZHK (German Center for Cardiovascular Research), Partner Site, Berlin, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.molmet.2016.08.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5081411PMC
November 2016

Tolerability, safety, and pharmacokinetics of the novel cathepsin A inhibitor SAR164653 in healthy subjects.

Clin Pharmacol Drug Dev 2016 Jan 24;5(1):57-68. Epub 2015 Sep 24.

Sanofi-Aventis Deutschland, Frankfurt a.M., Germany.

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http://dx.doi.org/10.1002/cpdd.201DOI Listing
January 2016

End-organ protection in hypertension by the novel and selective Rho-kinase inhibitor, SAR407899.

World J Cardiol 2015 Jan;7(1):31-42

Matthias Löhn, Oliver Plettenburg, Aimo Kannt, Markus Kohlmann, Armin Hofmeister, Dieter Kadereit, Peter Monecke, Alexander Schiffer, Anke Schulte, Hartmut Ruetten, Yuri Ivashchenko, Translational Medicine, Sanofi-Aventis, Industriepark Hoechst, 65926 Frankfurt am Main, Germany.

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http://dx.doi.org/10.4330/wjc.v7.i1.31DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4306204PMC
January 2015

Soluble guanylyl cyclase activation improves progressive cardiac remodeling and failure after myocardial infarction. Cardioprotection over ACE inhibition.

Basic Res Cardiol 2014 Jul 8;109(4):421. Epub 2014 Jun 8.

Klinik fuer Kardiologie und Angiologie, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, 30175, Hannover, Germany.

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http://dx.doi.org/10.1007/s00395-014-0421-1DOI Listing
July 2014

Cardioprotective effects of lixisenatide in rat myocardial ischemia-reperfusion injury studies.

J Transl Med 2013 Mar 28;11:84. Epub 2013 Mar 28.

Sanofi R&D Diabetes Division, Industriepark Hoechst, H825, 65926, Frankfurt/Main, Germany.

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http://dx.doi.org/10.1186/1479-5876-11-84DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3637243PMC
March 2013

Inhibition of CatA: an emerging strategy for the treatment of heart failure.

Future Med Chem 2013 Mar;5(4):399-409

SanofiDeutschland GmbH, Industriepark Höchst, 65926 Frankfurt, Germany.

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http://dx.doi.org/10.4155/fmc.13.24DOI Listing
March 2013

Effects of a novel amiodarone-like compound SAR114646A on the pig atrium and susceptibility to ventricular fibrillation in dogs and pigs.

Naunyn Schmiedebergs Arch Pharmacol 2012 Apr 11;385(4):373-84. Epub 2012 Jan 11.

Department of Physiology and Cell Biology, The Ohio State University, 304 Hamilton Hall, 1645 Neil Avenue, Columbus, OH 43210-1218, USA.

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http://link.springer.com/10.1007/s00210-011-0716-9
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http://dx.doi.org/10.1007/s00210-011-0716-9DOI Listing
April 2012

Effects of the novel amiodarone-like compound SAR114646A on cardiac ion channels and ventricular arrhythmias in rats.

Naunyn Schmiedebergs Arch Pharmacol 2011 Sep 16;384(3):231-44. Epub 2011 Jul 16.

Sanofi-Aventis Deutschland GmbH, Industriepark Hoechst, Frankfurt am Main, Germany.

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http://link.springer.com/content/pdf/10.1007/s00210-011-0664
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http://link.springer.com/10.1007/s00210-011-0664-4
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http://dx.doi.org/10.1007/s00210-011-0664-4DOI Listing
September 2011

Effect of dronedarone on Na+, Ca2+ and HCN channels.

Naunyn Schmiedebergs Arch Pharmacol 2011 Apr 29;383(4):347-56. Epub 2011 Jan 29.

Sanofi-Aventis Germany GmbH, Industriepark Hoechst, H 821, 65926, Frankfurt am Main, Germany.

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http://link.springer.com/10.1007/s00210-011-0599-9
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http://dx.doi.org/10.1007/s00210-011-0599-9DOI Listing
April 2011

Pharmacological characterization of SAR407899, a novel rho-kinase inhibitor.

Hypertension 2009 Sep 13;54(3):676-83. Epub 2009 Jul 13.

TD CV Pharmacology, Sanofi-Aventis, Industriepark Hoechst, Frankfurt am Main, Frankfurt, Germany.

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.109.134353DOI Listing
September 2009

Improvement in left ventricular remodeling by the endothelial nitric oxide synthase enhancer AVE9488 after experimental myocardial infarction.

Circulation 2008 Aug 4;118(8):818-27. Epub 2008 Aug 4.

Medizinische Klinik und Poliklinik I, Universitätsklinikum, Julius-Maximilians-Universität Würzburg, Würzburg, Germany.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.107.717702DOI Listing
August 2008

Simvastatin improves left ventricular function after myocardial infarction in hypercholesterolemic rabbits by anti-inflammatory effects.

Cardiovasc Res 2006 Dec 30;72(3):438-46. Epub 2006 Aug 30.

Medizinische Klinik und Poliklinik I, Universitätsklinikum, Universität Würzburg, Germany.

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http://dx.doi.org/10.1016/j.cardiores.2006.08.014DOI Listing
December 2006

Transcutaneous vascular ultrasound in hypercholesterolaemic rabbits: a new method to evaluate endothelial function.

Lab Anim 2006 Jan;40(1):80-6

Aventis Pharma Deutschland GmbH, Cardiovascular Therapeutic Department, 65926 Frankfurt, Germany.

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http://dx.doi.org/10.1258/002367706775404372DOI Listing
January 2006

Concentric left ventricular remodeling in endothelial nitric oxide synthase knockout mice by chronic pressure overload.

Cardiovasc Res 2005 Jun 24;66(3):444-53. Epub 2005 Feb 24.

Aventis Pharma, DG Cardiovascular Diseases, Industriepark Hoechst, Frankfurt a.M., Germany.

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http://dx.doi.org/10.1016/j.cardiores.2005.01.021DOI Listing
June 2005