Hartmut Kleinert

Hartmut Kleinert

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Hartmut Kleinert

Hartmut Kleinert

Publications by authors named "Hartmut Kleinert"

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The RNA-Binding Protein KSRP Modulates Cytokine Expression of CD4 T Cells.

J Immunol Res 2019 14;2019:4726532. Epub 2019 Aug 14.

Department of Pharmacology, University Medical Center of Johannes Gutenberg University, Mainz, Germany.

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http://dx.doi.org/10.1155/2019/4726532DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6714327PMC
August 2019

Regulation of human inducible nitric oxide synthase expression by an upstream open reading frame.

Nitric Oxide 2019 07 18;88:50-60. Epub 2019 Apr 18.

Department of Pharmacology, University Medical Center of the Johannes Gutenberg University Mainz, Obere Zahlbacher Str. 67, 55101, Mainz, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10898603183037
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http://dx.doi.org/10.1016/j.niox.2019.04.008DOI Listing
July 2019

The KH-type splicing regulatory protein (KSRP) regulates type III interferon expression post-transcriptionally.

Biochem J 2019 01 31;476(2):333-352. Epub 2019 Jan 31.

Department of Pharmacology, University Medical Center of the Johannes Gutenberg-University, Obere Zahlbacher Str. 67, 55101 Mainz, Germany

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http://biochemj.org/lookup/doi/10.1042/BCJ20180522
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http://dx.doi.org/10.1042/BCJ20180522DOI Listing
January 2019

Inactivation of the KSRP gene modifies collagen antibody induced arthritis.

Mol Immunol 2017 07 13;87:207-216. Epub 2017 May 13.

Department of Pharmacology, University Medical Center of the Johannes Gutenberg-University, Mainz, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01615890173011
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http://dx.doi.org/10.1016/j.molimm.2017.05.003DOI Listing
July 2017

Past, present and future of immunology in Mainz.

Cell Immunol 2016 10;308:1-6

Research Center for Immunotherapy (FZI), University Medical Center of the Johannes Gutenberg University, Mainz, Germany; Institute for Immunology, University Medical Center of the Johannes Gutenberg University, Mainz, Germany.

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http://dx.doi.org/10.1016/j.cellimm.2016.09.001DOI Listing
October 2016

Tristetraprolin regulation of interleukin-22 production.

Sci Rep 2015 Oct 21;5:15112. Epub 2015 Oct 21.

pharmazentrum frankfurt/ZAFES, University Hospital Goethe-University Frankfurt, Germany.

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http://dx.doi.org/10.1038/srep15112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4613560PMC
October 2015

The fungal lactone oxacyclododecindione is a potential new therapeutic substance in the treatment of lupus-associated kidney disease.

Kidney Int 2014 Oct 9;86(4):780-9. Epub 2014 Apr 9.

Department of Pharmacology, University Medical Center of the Johannes Gutenberg University, Mainz, Germany.

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http://dx.doi.org/10.1038/ki.2014.109DOI Listing
October 2014

Targeting V-ATPase in primary human monocytes by archazolid potently represses the classical secretion of cytokines due to accumulation at the endoplasmic reticulum.

Biochem Pharmacol 2014 Oct 12;91(4):490-500. Epub 2014 Aug 12.

Institute of Pharmacy, Friedrich Schiller University Jena, Philosophenweg 14, 07743 Jena, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.bcp.2014.07.028DOI Listing
October 2014

Post-transcriptional regulation of the human inducible nitric oxide synthase (iNOS) expression by the cytosolic poly(A)-binding protein (PABP).

Nitric Oxide 2013 Sep 25;33:6-17. Epub 2013 May 25.

Department of Pharmacology, University Medical Center of the Johannes Gutenberg University Mainz, D 55101 Mainz, Germany.

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http://dx.doi.org/10.1016/j.niox.2013.05.002DOI Listing
September 2013

Role of SIRT1 and FOXO factors in eNOS transcriptional activation by resveratrol.

Nitric Oxide 2013 Aug 10;32:29-35. Epub 2013 Apr 10.

Department of Pharmacology, University Medical Center, Johannes Gutenberg University, Mainz, Germany.

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http://dx.doi.org/10.1016/j.niox.2013.04.001DOI Listing
August 2013

Human inducible nitric oxide synthase (iNOS) expression depends on chromosome region maintenance 1 (CRM1)- and eukaryotic translation initiation factor 4E (elF4E)-mediated nucleocytoplasmic mRNA transport.

Nitric Oxide 2013 Apr 5;30:49-59. Epub 2013 Mar 5.

Department of Pharmacology, University Medical Center of the Johannes Gutenberg University Mainz, D 55101 Mainz, Germany.

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http://dx.doi.org/10.1016/j.niox.2013.02.083DOI Listing
April 2013

The anti-inflammatory fungal compound (S)-curvularin reduces proinflammatory gene expression in an in vivo model of rheumatoid arthritis.

J Pharmacol Exp Ther 2012 Oct 5;343(1):106-14. Epub 2012 Jul 5.

Department of Pharmacology, University Medical Center of the Johannes Gutenberg University, Mainz, Germany.

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http://jpet.aspetjournals.org/cgi/doi/10.1124/jpet.112.19204
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http://dx.doi.org/10.1124/jpet.112.192047DOI Listing
October 2012

Transcriptional regulation of Nox4 by histone deacetylases in human endothelial cells.

Basic Res Cardiol 2012 Sep 13;107(5):283. Epub 2012 Jul 13.

Department of Pharmacology, University Medical Center, Johannes Gutenberg University, Obere Zahlbacher Strasse 67, Mainz, Germany.

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http://dx.doi.org/10.1007/s00395-012-0283-3DOI Listing
September 2012

Heme oxygenase-1 induction and organic nitrate therapy: beneficial effects on endothelial dysfunction, nitrate tolerance, and vascular oxidative stress.

Int J Hypertens 2012 7;2012:842632. Epub 2012 Mar 7.

2nd Medical Clinic, Department of Cardiology, University Medical Center of the Johannes Gutenberg University, 55131 Mainz, Germany.

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http://dx.doi.org/10.1155/2012/842632DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3312327PMC
August 2012

Regulation of human mitochondrial aldehyde dehydrogenase (ALDH-2) activity by electrophiles in vitro.

J Biol Chem 2011 Mar 20;286(11):8893-900. Epub 2011 Jan 20.

II. Medizinische Klinik, Molekulare Kardiologie, Universitätsmedizin der Johannes Gutenberg-Universität Mainz, 55101 Mainz, Germany.

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http://dx.doi.org/10.1074/jbc.M110.190017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3058968PMC
March 2011

Induction of tolerogenic lung CD4+ T cells by local treatment with a pSTAT-3 and pSTAT-5 inhibitor ameliorated experimental allergic asthma.

Int Immunol 2011 Jan 6;23(1):1-15. Epub 2010 Dec 6.

Laboratory of Cellular and Molecular Immunology of Lung, Institute of Molecular Medicine, Universitätsmedizin Mainz, 55131 Mainz, Germany.

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http://dx.doi.org/10.1093/intimm/dxq451DOI Listing
January 2011

Regulation of the expression of inducible nitric oxide synthase.

Nitric Oxide 2010 Sep 8;23(2):75-93. Epub 2010 May 8.

Department of Pharmacology, University Medical Center of the Johannes Gutenberg University Mainz, D-55101 Mainz, Germany.

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https://linkinghub.elsevier.com/retrieve/pii/S10898603100005
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http://dx.doi.org/10.1016/j.niox.2010.04.007DOI Listing
September 2010

Transcriptional and post-transcriptional regulation of iNOS expression in human chondrocytes.

Biochem Pharmacol 2010 Mar 23;79(5):722-32. Epub 2009 Oct 23.

Department of Pharmacology, University Medical Center of the Johannes Gutenberg University Mainz, Obere Zahlbacher Strasse 67, D-55131 Mainz, Germany.

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http://dx.doi.org/10.1016/j.bcp.2009.10.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3951130PMC
March 2010

The RNA binding protein tristetraprolin influences the activation state of murine dendritic cells.

Mol Immunol 2010 Feb 28;47(5):1161-70. Epub 2009 Nov 28.

Department of Dermatology, University Medical Center of the Johannes Gutenberg-University, Mainz, Germany.

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http://dx.doi.org/10.1016/j.molimm.2009.11.002DOI Listing
February 2010

Effects of nitroglycerin or pentaerithrityl tetranitrate treatment on the gene expression in rat hearts: evidence for cardiotoxic and cardioprotective effects.

Physiol Genomics 2009 Jul 5;38(2):176-85. Epub 2009 May 5.

Department of Pharmacology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.

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http://dx.doi.org/10.1152/physiolgenomics.00035.2009DOI Listing
July 2009

Glyceraldehyde-3-phosphate dehydrogenase regulates endothelin-1 expression by a novel, redox-sensitive mechanism involving mRNA stability.

Mol Cell Biol 2008 Dec 22;28(23):7139-55. Epub 2008 Sep 22.

Centro de Investigaciones Biológicas, Consejo Superior de Investigaciones Científicas, Instituto Reina Sofía de Investigaciones Nefrológicas, Madrid, Spain.

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http://dx.doi.org/10.1128/MCB.01145-08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2593384PMC
December 2008

Inhibitors of inducible NO synthase expression: total synthesis of (S)-curvularin and its ring homologues.

ChemMedChem 2008 Jun;3(6):924-39

Institut für Organische Chemie, Naturstoffsynthese-Zentrum, Universität Mainz, Duesbergweg 10-14, 55128 Mainz, Germany.

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http://doi.wiley.com/10.1002/cmdc.200800022
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http://dx.doi.org/10.1002/cmdc.200800022DOI Listing
June 2008

ALDH-2 deficiency increases cardiovascular oxidative stress--evidence for indirect antioxidative properties.

Biochem Biophys Res Commun 2008 Feb 26;367(1):137-43. Epub 2007 Dec 26.

II. Medizinische Klinik, Labor für Molekulare Kardiologie, Johannes-Gutenberg-Universität Mainz, Langenbeck Str. 1, 55131 Mainz, Germany.

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http://linkinghub.elsevier.com/retrieve/pii/S0006291X0702754
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http://dx.doi.org/10.1016/j.bbrc.2007.12.089DOI Listing
February 2008

Regulation of cyclooxygenase-2 expression by cyclic AMP.

Biochim Biophys Acta 2007 Nov 12;1773(11):1605-18. Epub 2007 Sep 12.

Department of Biochemistry, ALTANA Pharma, D-78467 Konstanz, Germany.

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http://dx.doi.org/10.1016/j.bbamcr.2007.09.001DOI Listing
November 2007

Pentaerythrityl tetranitrate and nitroglycerin, but not isosorbide mononitrate, prevent endothelial dysfunction induced by ischemia and reperfusion.

Arterioscler Thromb Vasc Biol 2007 Sep 19;27(9):1955-9. Epub 2007 Jul 19.

Department of Internal, Cardiovascular, and Geriatric Medicine, Azienda Ospedaliera Universitaria Senese, University of Siena, Italy.

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http://dx.doi.org/10.1161/ATVBAHA.107.149278DOI Listing
September 2007

Differential haplotypic expression of the interleukin-18 gene.

Eur J Hum Genet 2007 Aug 9;15(8):856-63. Epub 2007 May 9.

INSERM, UMR S 525, Paris, France.

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http://www.nature.com/articles/5201842
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http://dx.doi.org/10.1038/sj.ejhg.5201842DOI Listing
August 2007

The interleukin-22/STAT3 pathway potentiates expression of inducible nitric-oxide synthase in human colon carcinoma cells.

J Biol Chem 2007 Jun 16;282(22):16006-15. Epub 2007 Apr 16.

Pharmazentrum Frankfurt/ZAFES, Klinikum der Johann Wolfgang Goethe-Universität Frankfurt am Main, 60590 Frankfurt am Main, Germany.

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http://dx.doi.org/10.1074/jbc.M611040200DOI Listing
June 2007

Post-transcriptional regulation of human inducible nitric-oxide synthase expression by the Jun N-terminal kinase.

Mol Pharmacol 2007 May 22;71(5):1427-34. Epub 2007 Feb 22.

Department of Pharmacology, Johannes Gutenberg University, Mainz, Germany.

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http://dx.doi.org/10.1124/mol.106.033449DOI Listing
May 2007

The polypyrimidine tract-binding protein (PTB) is involved in the post-transcriptional regulation of human inducible nitric oxide synthase expression.

J Biol Chem 2006 Oct 1;281(43):32294-302. Epub 2006 Sep 1.

Department of Pharmacology, Johannes Gutenberg University, Obere Zahlbacher Strasse 67, D-55101 Mainz, Germany.

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http://dx.doi.org/10.1074/jbc.M603915200DOI Listing
October 2006

Impact of Mycoplasma hyorhinis infection on L-arginine metabolism: differential regulation of the human and murine iNOS gene.

Biol Chem 2005 Oct;386(10):1055-63

Institute for Biochemistry and Molecular Biology I, Heinrich-Heine-University of Düsseldorf, Universitätsstr. 1, D-40225 Düsseldorf, Germany.

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http://dx.doi.org/10.1515/BC.2005.121DOI Listing
October 2005

Involvement of KSRP in the post-transcriptional regulation of human iNOS expression-complex interplay of KSRP with TTP and HuR.

Nucleic Acids Res 2005 26;33(15):4813-27. Epub 2005 Aug 26.

Department of Pharmacology, Johannes Gutenberg University, Obere Zahlbacher Strasse 67, D-55101 Mainz, Germany.

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https://academic.oup.com/nar/article-lookup/doi/10.1093/nar/
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http://dx.doi.org/10.1093/nar/gki797DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1192834PMC
September 2005

Tristetraprolin regulates the expression of the human inducible nitric-oxide synthase gene.

Mol Pharmacol 2005 Jun 18;67(6):2148-61. Epub 2005 Mar 18.

Department of Pharmacology, Johannes Gutenberg University, Obere Zahlbacher Strasse 67, 55101 Mainz, Germany.

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http://dx.doi.org/10.1124/mol.104.008763DOI Listing
June 2005

Regulation of the expression of inducible nitric oxide synthase.

Biol Chem 2003 Oct-Nov;384(10-11):1343-64

Department of Pharmacology, Johannes Gutenberg University, D-55101 Mainz, Germany.

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http://dx.doi.org/10.1515/BC.2003.152DOI Listing
October 2004

Regulation of the expression of inducible nitric oxide synthase.

Eur J Pharmacol 2004 Oct;500(1-3):255-66

Department of Pharmacology, Johannes Gutenberg University, Obere Zahlbacher Strasse 67, D-55101 Mainz, Germany.

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http://dx.doi.org/10.1016/j.ejphar.2004.07.030DOI Listing
October 2004

Lovastatin inhibits Rho-regulated expression of E-selectin by TNFalpha and attenuates tumor cell adhesion.

FASEB J 2004 Jan 20;18(1):140-2. Epub 2003 Nov 20.

University of Mainz, Institute of Toxicology, Division of Applied Toxicology, Mainz, Germany.

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http://dx.doi.org/10.1096/fj.03-0261fjeDOI Listing
January 2004

Green tea inhibits human inducible nitric-oxide synthase expression by down-regulating signal transducer and activator of transcription-1alpha activation.

Mol Pharmacol 2004 Jan;65(1):111-20

Biochemistry Section, Department of Neuroscience and Vision, University of Verona, Verona, Italy.

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http://dx.doi.org/10.1124/mol.65.1.111DOI Listing
January 2004

Rho protein-mediated changes in the structure of the actin cytoskeleton regulate human inducible NO synthase gene expression.

Exp Cell Res 2003 Jul;287(1):106-15

Department of Pharmacology, Johannes Gutenberg University, Obere Zahlbacher Strasse 67, D-55101, Mainz, Germany.

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http://dx.doi.org/10.1016/s0014-4827(03)00129-0DOI Listing
July 2003

Sporogen, S14-95, and S-curvularin, three inhibitors of human inducible nitric-oxide synthase expression isolated from fungi.

Mol Pharmacol 2003 Feb;63(2):383-91

Department of Pharmacology, Johannes Gutenberg University, Mainz, Germany.

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http://dx.doi.org/10.1124/mol.63.2.383DOI Listing
February 2003

Orphan nuclear receptor binding site in the human inducible nitric oxide synthase promoter mediates responsiveness to steroid and xenobiotic ligands.

J Cell Biochem 2002 ;85(1):72-82

Institute for Physiological Chemistry I, Heinrich-Heine-University, Düsseldorf, Germany.

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June 2002