Hartmut Juhl

Torvergata Oncoscience Research Centre of Excellence, TOR, Department of Experimental Medicine, University of Rome Tor Vergata, via Montpellier 1, 00133, Rome, Italy.

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October 2020

NGS Evaluation of Colorectal Cancer Reveals Interferon Gamma Dependent Expression of Immune Checkpoint Genes and Identification of Novel IFNγ Induced Genes.

Authors:

Lai Xu Lorraine Pelosof Rong Wang Hugh I McFarland Wells W Wu Je-Nie Phue Chun-Ting Lee Rong-Fong Shen Hartmut Juhl Lei-Hong Wu Wei-Lun Alterovitz Emanuel Petricon Amy S Rosenberg

Front Immunol 2020 19;11:224. Epub 2020 Mar 19.

Office of Biotechnology Products, Division of Biotechnology Review and Research III (DBRRIII), Office of Pharmaceutical Quality (OPQ), Center for Drug Evaluation and Research (CDER), FDA, Silver Spring, MD, United States.

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March 2020

Novel reference genes in colorectal cancer identify a distinct subset of high stage tumors and their associated histologically normal colonic tissues.

Authors:

Lai Xu Helen Luo Rong Wang Wells W Wu Je-Nie Phue Rong-Fong Shen Hartmut Juhl Leihong Wu Wei-Lun Alterovitz Vahan Simonyan Lorraine Pelosof Amy S Rosenberg

BMC Med Genet 2019 08 13;20(1):138. Epub 2019 Aug 13.

OBP/DBRR-III, CDER, FDA, Silver Spring, MD, 20993, USA.

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August 2019

Tumor Pre-Analytics in Molecular Pathology: Impact on Protein Expression and Analysis.

Authors:

Veronique M Neumeister Hartmut Juhl

Curr Pathobiol Rep 2018 6;6(4):265-274. Epub 2018 Sep 6.

Indivumed, GmbH, Falkenried 88, D-20251 Hamburg, Germany.

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September 2018

Multi-omic based molecular profiling of advanced cancer identifies treatable targets and improves survival in individual patients.

Authors:

Alexandra Samsen Silvia von der Heyde Carsten Bokemeyer Kerstin A David Bernd Flath Max Graap Bianca Grebenstein Ludger Heflik Wiebke Hollburg Peter Layer Eike von Leitner Friedrich Overkamp Wolfgang Saeger Sandra Schneider Cay-Uwe von Seydewitz Axel Stang Alexander Stein Carsten Zornig Hartmut Juhl

Oncotarget 2018 Oct 5;9(78):34794-34809. Epub 2018 Oct 5.

IndivuTest GmbH, Hamburg, Germany.

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October 2018

Comparison of central laboratory assessments of ER, PR, HER2, and Ki67 by IHC/FISH and the corresponding mRNAs (ESR1, PGR, ERBB2, and MKi67) by RT-qPCR on an automated, broadly deployed diagnostic platform.

Breast Cancer Res Treat 2018 Nov 17;172(2):327-338. Epub 2018 Aug 17.

Department of Pathology, Keck School of Medicine, USC/Norris Comprehensive Cancer Center, University of Southern California, 1441 Eastlake Avenue, STE. 5409, Los Angeles, CA, 90033-0800, USA.

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November 2018

Transcriptome analysis of human colorectal cancer biopsies reveals extensive expression correlations among genes related to cell proliferation, lipid metabolism, immune response and collagen catabolism.

Authors:

Lai Xu Rong Wang Joseph Ziegelbauer Wells W Wu Rong-Fong Shen Hartmut Juhl Yaqin Zhang Lorraine Pelosof Amy S Rosenberg

Oncotarget 2017 Sep 18;8(43):74703-74719. Epub 2017 Aug 18.

Office of Biotechnology Products, CDER, FDA, Silver Spring, MD 20993, USA.

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September 2017

Systematic biobanking, novel imaging techniques, and advanced molecular analysis for precise tumor diagnosis and therapy: The Polish MOBIT project.

Adv Med Sci 2017 Sep 21;62(2):405-413. Epub 2017 Jun 21.

Indivumed GmbH, Falkenreid 88, Hamburg, Germany.

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September 2017

Nanoproteomic analysis of ischemia-dependent changes in signaling protein phosphorylation in colorectal normal and cancer tissue.

Authors:

Florian T Unger Nicole Lange Jana Krüger Carolyn Compton Helen Moore Lokesh Agrawal Hartmut Juhl Kerstin A David

J Transl Med 2016 Jan 8;14. Epub 2016 Jan 8.

Indivumed GmbH, Falkenried 88, 20251, Hamburg, Germany.

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January 2016

Metabolomics profiling of pre-and post-anesthesia plasma samples of colorectal patients obtained via Ficoll separation.

Authors:

Veronica Ghini Florian T Unger Leonardo Tenori Paola Turano Hartmut Juhl Kerstin A David

Metabolomics 2015 25;11(6):1769-1778. Epub 2015 Jul 25.

Indivumed GmbH, Falkenried 88, 20251 Hamburg, Germany.

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July 2015

Distinct Profiles for Mitochondrial t-RNAs and Small Nucleolar RNAs in Locally Invasive and Metastatic Colorectal Cancer.

Authors:

Lai Xu Joseph Ziegelbauer Rong Wang Wells W Wu Rong-Fong Shen Hartmut Juhl Yaqin Zhang Amy Rosenberg

Clin Cancer Res 2016 Feb 18;22(3):773-84. Epub 2015 Sep 18.

OBP/DBRR-III, CDER, FDA, Silver Spring, Maryland.

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February 2016

Identification and Validation of a Potential Marker of Tissue Quality Using Gene Expression Analysis of Human Colorectal Tissue.

Authors:

Nicole Lange Florian T Unger Monika Schöppler Katja Pursche Hartmut Juhl Kerstin A David

PLoS One 2015 29;10(7):e0133987. Epub 2015 Jul 29.

Indivumed GmbH, Hamburg, Germany.

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May 2016

Surgical procedures and postsurgical tissue processing significantly affect expression of genes and EGFR-pathway proteins in colorectal cancer tissue.

Authors:

Kerstin A David Florian T Unger Philipp Uhlig Hartmut Juhl Helen M Moore Carolyn Compton Björn Nashan Arnulf Dörner Andreas de Weerth Carsten Zornig

Oncotarget 2014 Nov;5(22):11017-28

Surgical Clinic, Israelitisches Krankenhaus in Hamburg, Hamburg, Germany.

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November 2014

Detection of circulating tumor DNA in early- and late-stage human malignancies.

Authors:

Chetan Bettegowda Mark Sausen Rebecca J Leary Isaac Kinde Yuxuan Wang Nishant Agrawal Bjarne R Bartlett Hao Wang Brandon Luber Rhoda M Alani Emmanuel S Antonarakis Nilofer S Azad Alberto Bardelli Henry Brem John L Cameron Clarence C Lee Leslie A Fecher Gary L Gallia Peter Gibbs Dung Le Robert L Giuntoli Michael Goggins Michael D Hogarty Matthias Holdhoff Seung-Mo Hong Yuchen Jiao Hartmut H Juhl Jenny J Kim Giulia Siravegna Daniel A Laheru Calogero Lauricella Michael Lim Evan J Lipson Suely Kazue Nagahashi Marie George J Netto Kelly S Oliner Alessandro Olivi Louise Olsson Gregory J Riggins Andrea Sartore-Bianchi Kerstin Schmidt le-Ming Shih Sueli Mieko Oba-Shinjo Salvatore Siena Dan Theodorescu Jeanne Tie Timothy T Harkins Silvio Veronese Tian-Li Wang Jon D Weingart Christopher L Wolfgang Laura D Wood Dongmei Xing Ralph H Hruban Jian Wu Peter J Allen C Max Schmidt Michael A Choti Victor E Velculescu Kenneth W Kinzler Bert Vogelstein Nickolas Papadopoulos Luis A Diaz

Sci Transl Med 2014 Feb;6(224):224ra24

Ludwig Center for Cancer Genetics and Therapeutics, Howard Hughes Medical Institute and the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21231, USA.

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February 2014

Recurrence of early stage colon cancer predicted by expression pattern of circulating microRNAs.

Authors:

Narayan Shivapurkar Louis M Weiner John L Marshall Subha Madhavan Anne Deslattes Mays Hartmut Juhl Anton Wellstein

PLoS One 2014 6;9(1):e84686. Epub 2014 Jan 6.

Lombardi Cancer Center, Georgetown University, Washington, District of Columbia, United States of America.

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September 2014

Genome-wide multi-omics profiling of colorectal cancer identifies immune determinants strongly associated with relapse.

Authors:

Subha Madhavan Yuriy Gusev Thanemozhi G Natarajan Lei Song Krithika Bhuvaneshwar Robinder Gauba Abhishek Pandey Bassem R Haddad David Goerlitz Amrita K Cheema Hartmut Juhl Bhaskar Kallakury John L Marshall Stephen W Byers Louis M Weiner

Front Genet 2013 20;4:236. Epub 2013 Nov 20.

Department of Oncology, Innovation Center for Biomedical Informatics, Georgetown University Medical Center Washington, DC, USA ; Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center Washington DC, USA.

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December 2013

Platform for Personalized Oncology: Integrative analyses reveal novel molecular signatures associated with colorectal cancer relapse.

Authors:

Subha Madhavan Robinder Gauba Lei Song Krithika Bhuvaneshwar Yuriy Gusev Steve Byers Hartmut Juhl Louis Weiner

AMIA Jt Summits Transl Sci Proc 2013 18;2013:118. Epub 2013 Mar 18.

Innovation Center for Biomedical Informatics, Georgetown University, Washington DC, USA.

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December 2013

Determination of phosphorylated proteins in tissue specimens requires high-quality samples collected under stringent conditions.

Authors:

Corinna Wolf Tiantom Jarutat Suzana Vega Harring Kristin Haupt Galina Babitzki Sabine Bader Kerstin David Hartmut Juhl Susanne Arbogast

Histopathology 2014 Feb 23;64(3):431-44. Epub 2013 Nov 23.

Department for Tissue Biomarkers and Pathology, Roche Diagnostics GmbH, Penzberg, Germany.

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February 2014

A novel function of RNAs arising from the long terminal repeat of human endogenous retrovirus 9 in cell cycle arrest.

Authors:

Lai Xu Abdel G Elkahloun Fabio Candotti Andrzej Grajkowski Serge L Beaucage Emanuel F Petricoin Valerie Calvert Hartmut Juhl Frederick Mills Karen Mason Neal Shastri Josh Chik Cynthia Xu Amy S Rosenberg

J Virol 2013 Jan 24;87(1):25-36. Epub 2012 Oct 24.

Division of Therapeutic Proteins, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland, USA.

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January 2013

What improvements would you recommend in the collection of control samples?

Authors:

Jane Carpenter Helen M Moore Hartmut Juhl Geraldine Thomas Lisa B Miranda

Biopreserv Biobank 2011 Jun;9(2):129-31

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June 2011

Preanalytical aspects: a neglected issue.

Authors:

Hartmut Juhl

Scand J Clin Lab Invest Suppl 2010 ;242:63-5

Indivumed GmbH, Hamburg, Germany.

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September 2010

Sensitive digital quantification of DNA methylation in clinical samples.

Nat Biotechnol 2009 Sep 16;27(9):858-63. Epub 2009 Aug 16.

The Ludwig Center for Cancer Genetics and Therapeutics, Howard Hughes Medical Institute and Sidney Kimmel Cancer Center at the Johns Hopkins Medical Institutions, Baltimore, Maryland, USA.

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September 2009

Detection of colorectal adenoma and cancer based on transthyretin and C3a-desArg serum levels.

Authors:

Anne-Kristin Fentz Monika Spörl Jörg Spangenberg Heinz Joachim List Carsten Zornig Arnulf Dörner Peter Layer Hartmut Juhl Kerstin A David

Proteomics Clin Appl 2007 Jun 14;1(6):536-44. Epub 2007 May 14.

Indivumed GmbH, Center for Cancer Research, Israelitisches Krankenhaus, Hamburg, Germany.

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June 2007

The colorectal microRNAome.

Authors:

Jordan M Cummins Yiping He Rebecca J Leary Ray Pagliarini Luis A Diaz Tobias Sjoblom Omer Barad Zvi Bentwich Anna E Szafranska Emmanuel Labourier Christopher K Raymond Brian S Roberts Hartmut Juhl Kenneth W Kinzler Bert Vogelstein Victor E Velculescu

Proc Natl Acad Sci U S A 2006 Mar 27;103(10):3687-92. Epub 2006 Feb 27.

The Sidney Kimmel Comprehensive Cancer Center and Howard Hughes Medical Institute, Johns Hopkins University Medical Institutions, Baltimore, MD 21231, USA.

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March 2006

Detection and quantification of mutations in the plasma of patients with colorectal tumors.

Authors:

Frank Diehl Meng Li Devin Dressman Yiping He Dong Shen Steve Szabo Luis A Diaz Steven N Goodman Kerstin A David Hartmut Juhl Kenneth W Kinzler Bert Vogelstein

Proc Natl Acad Sci U S A 2005 Nov 28;102(45):16368-73. Epub 2005 Oct 28.

Howard Hughes Medical Institute and The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins Medical Institutions, 1650 Orleans Street, Baltimore, MD 21231, USA.

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November 2005