Hartmut Geiger

Hartmut Geiger

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Hartmut Geiger

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Latexin regulation by HMGB2 is required for hematopoietic stem cell maintenance.

Haematologica 2020 Mar 6;105(3):573-584. Epub 2019 Jun 6.

Departments of Toxicology and Cancer Biology, University of Kentucky, Lexington, KY, USA

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http://dx.doi.org/10.3324/haematol.2018.207092DOI Listing
March 2020

TLR4-dependent shaping of the wound site by MSCs accelerates wound healing.

EMBO Rep 2020 Mar 12:e48777. Epub 2020 Mar 12.

Department of Dermatology and Allergic Diseases, Ulm University, Ulm, Germany.

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http://dx.doi.org/10.15252/embr.201948777DOI Listing
March 2020

HPRT and Purine Salvaging Are Critical for Hematopoietic Stem Cell Function.

Stem Cells 2019 12 12;37(12):1606-1614. Epub 2019 Oct 12.

Institute of Molecular Medicine, Ulm University, Ulm, Germany.

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http://dx.doi.org/10.1002/stem.3087DOI Listing
December 2019

KRas expression in the bone marrow vascular niche affects hematopoiesis with inflammatory signals.

Exp Hematol 2019 11 24;79:3-15.e4. Epub 2019 Oct 24.

Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio; Department of Pathology and Laboratory Medicine, University of Cincinnati, Cincinnati, Ohio. Electronic address:

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http://dx.doi.org/10.1016/j.exphem.2019.10.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6921092PMC
November 2019

Hematopoietic Stem Cell Dynamics Are Regulated by Progenitor Demand: Lessons from a Quantitative Modeling Approach.

Stem Cells 2019 07 3;37(7):948-957. Epub 2019 Apr 3.

Institute for Medical Informatics and Biometry, Carl Gustav Carus Faculty of Medicine, Technische Universität Dresden, Dresden, Germany.

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http://dx.doi.org/10.1002/stem.3005DOI Listing
July 2019

Chromosome integrity checkpoints in stem and progenitor cells: transitions upon differentiation, pathogenesis, and aging.

Cell Mol Life Sci 2018 Oct 31;75(20):3771-3779. Epub 2018 Jul 31.

Institute of Molecular Medicine, Ulm University, Life Science Building N27, James Franck-Ring/Meyerhofstrasse, 89081, Ulm, Germany.

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http://dx.doi.org/10.1007/s00018-018-2891-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6154040PMC
October 2018

A non-myeloablative conditioning approach for long-term engraftment of human and mouse hematopoietic stem cells.

Leukemia 2018 09 29;32(9):2041-2046. Epub 2018 Jun 29.

Cancer and Blood Diseases Institute, Molecular and Developmental Biology Graduate Program, Children's Hospital Research Foundation, 3333 Burnet Avenue, Cincinnati, OH, 45229, USA.

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http://dx.doi.org/10.1038/s41375-018-0200-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6128741PMC
September 2018

Epigenetic age-predictor for mice based on three CpG sites.

Elife 2018 08 24;7. Epub 2018 Aug 24.

Helmholtz-Institute for Biomedical Engineering, Stem Cell Biology and Cellular Engineering, RWTH Aachen University Medical School, Aachen, Germany.

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http://dx.doi.org/10.7554/eLife.37462DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156076PMC
August 2018

Loss of DEK induces radioresistance of murine restricted hematopoietic progenitors.

Exp Hematol 2018 03 27;59:40-50.e3. Epub 2017 Dec 27.

Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio. Electronic address:

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http://dx.doi.org/10.1016/j.exphem.2017.12.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5844846PMC
March 2018

Special section: Replication stress, a threat to the nuclear and mitochondrial genome.

Mutat Res 2018 03 5;808:53-55. Epub 2018 Jan 5.

Department of Obstetrics and Gynecology, Ulm University, Germany; Department of Dermatology and Allergic Diseases, Ulm University, Germany,; Institute of Molecular Medicine, Ulm University, Germany,. Electronic address:

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http://dx.doi.org/10.1016/j.mrfmmm.2018.01.001DOI Listing
March 2018

RHOA GTPase Controls YAP-Mediated EREG Signaling in Small Intestinal Stem Cell Maintenance.

Stem Cell Reports 2017 12 9;9(6):1961-1975. Epub 2017 Nov 9.

Division of Experimental Hematology & Cancer Biology, Cincinnati Children's Hospital Research Foundation, 3333 Burnet Avenue, Cincinnati, OH 45229, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2017.10.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5785633PMC
December 2017

Balance your folate or the yin and yang of folate in hematopoiesis.

Authors:
Hartmut Geiger

Haematologica 2017 12;102(12):1969-1970

Institute of Molecular Medicine and Aging Research Center, University of Ulm, Germany and Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.

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http://dx.doi.org/10.3324/haematol.2017.179838DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5709094PMC
December 2017

Septin 6 regulates engraftment and lymphoid differentiation potential of murine long-term hematopoietic stem cells.

Exp Hematol 2017 11 24;55:45-55. Epub 2017 Jul 24.

Institute of Molecular Medicine, University of Ulm, Ulm, Germany; Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Research Foundation, Cincinnati, OH. Electronic address:

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http://dx.doi.org/10.1016/j.exphem.2017.07.005DOI Listing
November 2017

The Spindle Assembly Checkpoint Is Required for Hematopoietic Progenitor Cell Engraftment.

Stem Cell Reports 2017 11 19;9(5):1359-1368. Epub 2017 Oct 19.

Institute of Molecular Medicine, Ulm University, Ulm 89081, Germany; Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center and University of Cincinnati, Cincinnati, OH, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2017.09.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5830991PMC
November 2017

HSC Niche Biology and HSC Expansion Ex Vivo.

Trends Mol Med 2017 09 8;23(9):799-819. Epub 2017 Aug 8.

Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Research Foundation, Cincinnati, OH 45229, USA; Institute of Molecular Medicine, Ulm University, Ulm, Germany; Aging Research Center, Ulm University, Ulm, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.molmed.2017.07.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5600322PMC
September 2017

Vitamin A-Retinoic Acid Signaling Regulates Hematopoietic Stem Cell Dormancy.

Cell 2017 May 4;169(5):807-823.e19. Epub 2017 May 4.

Division of Stem Cells and Cancer, German Cancer Research Center (DKFZ) and DKFZ-ZMBH Alliance, 69120 Heidelberg, Germany; Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH), 69120 Heidelberg, Germany; German Cancer Consortium (DKTK), 69120 Heidelberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2017.04.018DOI Listing
May 2017

Latexin Inactivation Enhances Survival and Long-Term Engraftment of Hematopoietic Stem Cells and Expands the Entire Hematopoietic System in Mice.

Stem Cell Reports 2017 04 16;8(4):991-1004. Epub 2017 Mar 16.

Department of Toxicology and Cancer Biology, University of Kentucky, Health Sciences Research Building Room 340, 1095 V.A. Drive, Lexington, KY 40536, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2017.02.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5390104PMC
April 2017

Limitations and challenges of genetic barcode quantification.

Sci Rep 2017 03 3;7:43249. Epub 2017 Mar 3.

Research Dept. Cell and Gene Therapy, Department of Stem Cell Transplantation, University Medical Centre Hamburg-Eppendorf, Martinistr. 52, 20246 Hamburg, Germany.

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http://dx.doi.org/10.1038/srep43249DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5335698PMC
March 2017

Canonical Wnt Signaling Ameliorates Aging of Intestinal Stem Cells.

Cell Rep 2017 03;18(11):2608-2621

Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center and University of Cincinnati, Cincinnati, OH 45229, USA; Institute for Molecular Medicine, Stem Cells, and Aging and Aging Research Center, Ulm University, 89081 Ulm, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.02.056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5987258PMC
March 2017

Rejuvenation of aged hematopoietic stem cells.

Semin Hematol 2017 01 24;54(1):51-55. Epub 2016 Oct 24.

Institute for Molecular Medicine, Ulm University, Ulm, Germany; Division of Experimental Hematology and Cancer Biology, Cincinnati Children׳s Hospital Medical Center, Cincinnati, OH, USA; Aging Research Center, Ulm University, Ulm, Germany. Electronic address:

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http://dx.doi.org/10.1053/j.seminhematol.2016.10.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5244470PMC
January 2017

Aging of hematopoietic stem cells: DNA damage and mutations?

Exp Hematol 2016 10 8;44(10):895-901. Epub 2016 Jul 8.

Institute for Molecular Medicine, Ulm University, Ulm, Germany; Aging Research Center, Ulm University, Ulm, Germany; Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH. Electronic address:

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http://dx.doi.org/10.1016/j.exphem.2016.06.253DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5035607PMC
October 2016

Aging, Clonality, and Rejuvenation of Hematopoietic Stem Cells.

Trends Mol Med 2016 08 2;22(8):701-712. Epub 2016 Jul 2.

Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Research Foundation, Cincinnati, OH 45229, USA; Institute for Molecular Medicine, Ulm University, 89081 Ulm, Germany; aging research center, Ulm University, 89081 Ulm, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.molmed.2016.06.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4969095PMC
August 2016

Quantitative trait gene Slit2 positively regulates murine hematopoietic stem cell numbers.

Sci Rep 2016 08 9;6:31412. Epub 2016 Aug 9.

Department of Toxicology and Cancer Biology, University of Kentucky, Lexington, KY, USA.

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http://dx.doi.org/10.1038/srep31412DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4977545PMC
August 2016

Depleting senescent cells to combat aging.

Authors:
Hartmut Geiger

Nat Med 2016 Jan;22(1):23-4

Institute for Molecular Medicine and Aging Research Center Ulm, University of Ulm, Ulm, Germany, and in the Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.

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http://dx.doi.org/10.1038/nm.4024DOI Listing
January 2016

HSC Aging and Senescent Immune Remodeling.

Trends Immunol 2015 Dec 21;36(12):815-824. Epub 2015 Nov 21.

Institute for Molecular Medicine, Stem Cells and Aging, Ulm University, Ulm, Germany; aging research center, Ulm University, Ulm, Germany; Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center and University of Cincinnati, Cincinnati, OH, USA. Electronic address:

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http://dx.doi.org/10.1016/j.it.2015.10.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4710174PMC
December 2015

Stem Cell-Specific Mechanisms Ensure Genomic Fidelity within HSCs and upon Aging of HSCs.

Cell Rep 2015 Dec 10;13(11):2412-2424. Epub 2015 Dec 10.

Institute of Molecular Medicine, University of Ulm, 89081 Ulm, Germany; Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center and University of Cincinnati, Cincinnati, OH 45229, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.11.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4691560PMC
December 2015

Inflammation-Induced Emergency Megakaryopoiesis Driven by Hematopoietic Stem Cell-like Megakaryocyte Progenitors.

Cell Stem Cell 2015 Oct 20;17(4):422-34. Epub 2015 Aug 20.

Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH), 69120 Heidelberg, Germany; Division of Stem Cells and Cancer, Hematopoietic Stem Cells and Stress Group, Deutsches Krebsforschungszentrum (DKFZ), 69120 Heidelberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2015.07.007DOI Listing
October 2015

Exit from dormancy provokes DNA-damage-induced attrition in haematopoietic stem cells.

Nature 2015 Apr 18;520(7548):549-52. Epub 2015 Feb 18.

1] Heidelberg Institute for Stem Cell Technology and Experimental Medicine gGmbH (HI-STEM), 69120 Heidelberg, Germany [2] Deutsches Krebsforschungszentrum (DKFZ), Division of Stem Cells and Cancer, Experimental Hematology Group, 69120 Heidelberg, Germany.

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http://dx.doi.org/10.1038/nature14131DOI Listing
April 2015

Regulation of hematopoietic stem cell aging by the small RhoGTPase Cdc42.

Exp Cell Res 2014 Dec 16;329(2):214-9. Epub 2014 Sep 16.

Division of Experimental Hematology and Cancer Biology, Cincinnati Children׳s Hospital Medical Center and University of Cincinnati, Cincinnati, OH 45229, USA.

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http://dx.doi.org/10.1016/j.yexcr.2014.09.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4427663PMC
December 2014

Hematopoietic stem cell aging.

Curr Opin Immunol 2014 Aug 3;29:86-92. Epub 2014 Jun 3.

Department of Internal Medicine I, University Hospital of Ulm, Ulm, Germany.

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http://dx.doi.org/10.1016/j.coi.2014.05.002DOI Listing
August 2014

HSC senescence upon irradiation.

Authors:
Hartmut Geiger

Blood 2014 May;123(20):3060-1

ULM UNIVERSITY; CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER.

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http://dx.doi.org/10.1182/blood-2014-03-563718DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4023413PMC
May 2014

HSPCs get their motors running for asymmetric fate choice.

Cell Stem Cell 2014 Jan;14(1):1-2

Division of Experimental Hematology and Cancer Biology, Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA; Institute for Molecular Medicine, University of Ulm, Ulm 89081, Germany.

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http://dx.doi.org/10.1016/j.stem.2013.12.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3916825PMC
January 2014

RhoA GTPase controls cytokinesis and programmed necrosis of hematopoietic progenitors.

J Exp Med 2013 Oct 7;210(11):2371-85. Epub 2013 Oct 7.

Division of Experimental Hematology and Cancer Biology, 2 Molecular and Development Biology Graduate Program, 3 Division of Ophthalmology, and 4 Division of Developmental Biology, Cincinnati Children's Research Foundation, University of Cincinnati, Cincinnati, OH 45229.

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http://jem.rupress.org/content/210/11/2371.full.pdf
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http://www.jem.org/lookup/doi/10.1084/jem.20122348
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http://dx.doi.org/10.1084/jem.20122348DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3804933PMC
October 2013

Cdc42 and aging of hematopoietic stem cells.

Curr Opin Hematol 2013 Jul;20(4):295-300

Department of Dermatology and Allergic Diseases, University of Ulm, Ulm, Germany.

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http://dx.doi.org/10.1097/MOH.0b013e3283615abaDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4057184PMC
July 2013

The ageing haematopoietic stem cell compartment.

Nat Rev Immunol 2013 May 15;13(5):376-89. Epub 2013 Apr 15.

Department of Dermatology and Allergic Diseases, University of Ulm, 89091 Ulm, Germany.

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http://dx.doi.org/10.1038/nri3433DOI Listing
May 2013

Aging of the microenvironment influences clonality in hematopoiesis.

PLoS One 2012 6;7(8):e42080. Epub 2012 Aug 6.

Department of Dermatology and Allergic Diseases, University of Ulm, Ulm, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0042080PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3412859PMC
January 2013

Contribution of an aged microenvironment to aging-associated myeloproliferative disease.

PLoS One 2012 21;7(2):e31523. Epub 2012 Feb 21.

Department of Dermatology and Allergic Diseases, University of Ulm, Ulm, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0031523PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3283638PMC
June 2012

Imaging hematopoietic stem cells in the marrow of long bones in vivo.

Methods Mol Biol 2011 ;750:215-24

Institute for Molecular and Clinical Immunology, Otto von Guericke University, Magdeburg, Germany.

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http://dx.doi.org/10.1007/978-1-61779-145-1_15DOI Listing
September 2011

Immunoaging induced by hematopoietic stem cell aging.

Curr Opin Immunol 2011 Aug;23(4):532-6

Institute of Molecular Medicine and Max-Planck-Research, Department on Stem Cell Aging, Ulm University, Germany.

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http://dx.doi.org/10.1016/j.coi.2011.05.004DOI Listing
August 2011

R-Ras and Rac GTPase cross-talk regulates hematopoietic progenitor cell migration, homing, and mobilization.

J Biol Chem 2011 Jul 13;286(27):24068-78. Epub 2011 May 13.

Division of Experimental Hematology and Cancer Biology, Children's Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio 45229, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M111.226951
Publisher Site
http://dx.doi.org/10.1074/jbc.M111.226951DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3129188PMC
July 2011

Concise review: polarity in stem cells, disease, and aging.

Stem Cells 2010 Sep;28(9):1623-9

Department of Dermatology and Allergic Diseases, University of Ulm, Ulm, Germany.

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http://dx.doi.org/10.1002/stem.481DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2996084PMC
September 2010

Rac1 and Rac2 GTPases are necessary for early erythropoietic expansion in the bone marrow but not in the spleen.

Haematologica 2010 Jan;95(1):27-35

Division of Hematology/Oncology, Oncology, Cincinnati Children's Research Foundation, Cincinnati Children's Hospital Medical Center, MLC 7015 Cincinnati, OH 45229-3039, USA.

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http://dx.doi.org/10.3324/haematol.2009.006239DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2805739PMC
January 2010

Loss of the Rho GTPase activating protein p190-B enhances hematopoietic stem cell engraftment potential.

Blood 2009 Oct 27;114(17):3557-66. Epub 2009 Aug 27.

Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Research Foundation, Cincinnati, OH 45229, USA.

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http://dx.doi.org/10.1182/blood-2009-02-205815DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2766675PMC
October 2009

Aging in the lympho-hematopoietic stem cell compartment.

Trends Immunol 2009 Jul 18;30(7):360-5. Epub 2009 Jun 18.

Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.

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http://dx.doi.org/10.1016/j.it.2009.03.010DOI Listing
July 2009

Possible leukemogenic potential of temozolomide.

Pediatr Blood Cancer 2009 Apr;52(4):553

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http://dx.doi.org/10.1002/pbc.21865DOI Listing
April 2009

Quantification of genomic mutations in murine hematopoietic cells.

Methods Mol Biol 2009 ;506:423-36

Department of Medicine, University of Cincinnati, Cincinnati, OH, USA.

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http://link.springer.com/10.1007/978-1-59745-409-4_28
Publisher Site
http://dx.doi.org/10.1007/978-1-59745-409-4_28DOI Listing
February 2009

Nf1 mutation expands an EGFR-dependent peripheral nerve progenitor that confers neurofibroma tumorigenic potential.

Cell Stem Cell 2008 Dec;3(6):658-69

Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Research Foundation, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA.

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http://dx.doi.org/10.1016/j.stem.2008.10.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3487385PMC
December 2008

Targeting erythroblast-specific apoptosis in experimental anemia.

Apoptosis 2008 Aug;13(8):1022-30

Center for Molecular Cardiovascular Research, University of Cincinnati, Cincinnati, OH, USA.

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http://dx.doi.org/10.1007/s10495-008-0236-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2556039PMC
August 2008

p53 signaling in response to increased DNA damage sensitizes AML1-ETO cells to stress-induced death.

Blood 2008 Feb 1;111(4):2190-9. Epub 2007 Nov 1.

Division of Experimental Hematology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, OH 45226, USA.

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http://dx.doi.org/10.1182/blood-2007-06-093682DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2234055PMC
February 2008

The retinoblastoma tumor suppressor is a critical intrinsic regulator for hematopoietic stem and progenitor cells under stress.

Blood 2008 Feb 29;111(4):1894-902. Epub 2007 Nov 29.

Division of Experimental Hematology, Cincinnati Children's Hospital Medical Center, Department of Medicine, University of Cincinnati, OH 45229, USA.

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http://dx.doi.org/10.1182/blood-2007-02-071746DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2234042PMC
February 2008

TNF-alpha induces leukemic clonal evolution ex vivo in Fanconi anemia group C murine stem cells.

J Clin Invest 2007 Nov;117(11):3283-95

Division of Experimental Hematology, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA.

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http://dx.doi.org/10.1172/JCI31772DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2040318PMC
November 2007

Stem cells, aging, niche, adhesion and Cdc42: a model for changes in cell-cell interactions and hematopoietic stem cell aging.

Cell Cycle 2007 Apr 7;6(8):884-7. Epub 2007 Apr 7.

Division of Experimental Hematology, Cincinnati Children's Hospital Medical Center, Department of Medicine, University of Cincinnati, Cincinnati, Ohio 45229, USA.

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http://dx.doi.org/10.4161/cc.6.8.4131DOI Listing
April 2007

Unrestrained erythroblast development in Nix-/- mice reveals a mechanism for apoptotic modulation of erythropoiesis.

Proc Natl Acad Sci U S A 2007 Apr 9;104(16):6794-9. Epub 2007 Apr 9.

Center for Molecular Cardiovascular Research and Department of Pediatrics, Children's Hospital Medical Center, University of Cincinnati, Cincinnati, OH 45267, USA.

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http://dx.doi.org/10.1073/pnas.0610666104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1849960PMC
April 2007

Rho GTPase Cdc42 coordinates hematopoietic stem cell quiescence and niche interaction in the bone marrow.

Proc Natl Acad Sci U S A 2007 Mar 12;104(12):5091-6. Epub 2007 Mar 12.

Division of Experimental Hematology and Pathology, Cincinnati Children's Research Foundation, Molecular Developmental Biology Graduate Program, University of Cincinnati, Cincinnati, OH 45229, USA.

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http://dx.doi.org/10.1073/pnas.0610819104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1829299PMC
March 2007

The impact of altered p53 dosage on hematopoietic stem cell dynamics during aging.

Blood 2007 Feb 10;109(4):1736-42. Epub 2006 Oct 10.

Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, and Division of Experimental Hematology, Cincinnati Children's Hospital Medical Center, OH, USA.

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http://dx.doi.org/10.1182/blood-2006-03-010413DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1794064PMC
February 2007

The quantitative trait gene latexin influences the size of the hematopoietic stem cell population in mice.

Nat Genet 2007 Feb 14;39(2):178-88. Epub 2007 Jan 14.

Department of Internal Medicine, University of Kentucky, Lexington, Kentucky 40536, USA.

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http://dx.doi.org/10.1038/ng1938DOI Listing
February 2007

Increased hematopoietic stem cell mobilization in aged mice.

Blood 2006 Oct 1;108(7):2190-7. Epub 2006 Jun 1.

Division of Experimental Hematology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229, USA.

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http://dx.doi.org/10.1182/blood-2005-12-010272DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1895568PMC
October 2006

Isolation of neural precursor cells from Alzheimer's disease and aged control postmortem brain.

Neurobiol Aging 2006 Jul 23;27(7):909-17. Epub 2005 Jun 23.

Sanders-Brown Center on Aging and Alzheimer's Disease Research Center, 800 S. Limestone St., 101 Sanders-Brown Bldg., University of Kentucky, Lexington, KY 40536-0230, USA.

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http://dx.doi.org/10.1016/j.neurobiolaging.2005.05.004DOI Listing
July 2006

Regulation of hematopoietic stem cell aging in vivo by a distinct genetic element.

Proc Natl Acad Sci U S A 2005 Apr 23;102(14):5102-7. Epub 2005 Mar 23.

Division of Experimental Hematology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA.

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http://dx.doi.org/10.1073/pnas.0408654102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC555968PMC
April 2005

The Collaborative Cross, a community resource for the genetic analysis of complex traits.

Authors:
Gary A Churchill David C Airey Hooman Allayee Joe M Angel Alan D Attie Jackson Beatty William D Beavis John K Belknap Beth Bennett Wade Berrettini Andre Bleich Molly Bogue Karl W Broman Kari J Buck Ed Buckler Margit Burmeister Elissa J Chesler James M Cheverud Steven Clapcote Melloni N Cook Roger D Cox John C Crabbe Wim E Crusio Ariel Darvasi Christian F Deschepper R W Doerge Charles R Farber Jiri Forejt Daniel Gaile Steven J Garlow Hartmut Geiger Howard Gershenfeld Terry Gordon Jing Gu Weikuan Gu Gerald de Haan Nancy L Hayes Craig Heller Heinz Himmelbauer Robert Hitzemann Kent Hunter Hui-Chen Hsu Fuad A Iraqi Boris Ivandic Howard J Jacob Ritsert C Jansen Karl J Jepsen Dabney K Johnson Thomas E Johnson Gerd Kempermann Christina Kendziorski Malak Kotb R Frank Kooy Bastien Llamas Frank Lammert Jean-Michel Lassalle Pedro R Lowenstein Lu Lu Aldons Lusis Kenneth F Manly Ralph Marcucio Doug Matthews Juan F Medrano Darla R Miller Guy Mittleman Beverly A Mock Jeffrey S Mogil Xavier Montagutelli Grant Morahan David G Morris Richard Mott Joseph H Nadeau Hiroki Nagase Richard S Nowakowski Bruce F O'Hara Alexander V Osadchuk Grier P Page Beverly Paigen Kenneth Paigen Abraham A Palmer Huei-Ju Pan Leena Peltonen-Palotie Jeremy Peirce Daniel Pomp Michal Pravenec Daniel R Prows Zhonghua Qi Roger H Reeves John Roder Glenn D Rosen Eric E Schadt Leonard C Schalkwyk Ze'ev Seltzer Kazuhiro Shimomura Siming Shou Mikko J Sillanpää Linda D Siracusa Hans-Willem Snoeck Jimmy L Spearow Karen Svenson Lisa M Tarantino David Threadgill Linda A Toth William Valdar Fernando Pardo-Manuel de Villena Craig Warden Steve Whatley Robert W Williams Tim Wiltshire Nengjun Yi Dabao Zhang Min Zhang Fei Zou

Nat Genet 2004 Nov;36(11):1133-7

The Jackson Laboratory, 600 Main Street Bar Harbor, Maine 04609, USA.

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http://dx.doi.org/10.1038/ng1104-1133DOI Listing
November 2004

Genetic analysis of progenitor cell mobilization by granulocyte colony-stimulating factor: verification and mechanisms for loci on murine chromosomes 2 and 11.

Exp Hematol 2004 Jan;32(1):60-7

Department of Internal Medicine, University of Kentucky Medical Center, Lexington, Ky., USA.

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http://dx.doi.org/10.1016/j.exphem.2003.09.015DOI Listing
January 2004

A genetic and genomic analysis identifies a cluster of genes associated with hematopoietic cell turnover.

Blood 2002 Sep;100(6):2056-62

Department of Stem Cell Biology, University of Groningen, A. Deusinglaan 1, 9713 AV Groningen, The Netherlands.

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http://dx.doi.org/10.1182/blood-2002-03-0808DOI Listing
September 2002

Analysis of the hematopoietic potential of muscle-derived cells in mice.

Blood 2002 Jul;100(2):721-3

Department of Internal Medicine, University of Kentucky Medical Center, Lexington, KY 40536, USA.

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http://dx.doi.org/10.1182/blood.v100.2.721DOI Listing
July 2002

Genetically determined variation in the number of phenotypically defined hematopoietic progenitor and stem cells and in their response to early-acting cytokines.

Blood 2002 Jun;99(11):3947-54

Carl C. Icahn Institute for Gene Therapy and Molecular Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA.

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http://dx.doi.org/10.1182/blood.v99.11.3947DOI Listing
June 2002

Age-related change in thymic T-cell development is associated with genetic loci on mouse chromosomes 1, 3, and 11.

Mech Ageing Dev 2002 Apr;123(8):1145-58

Division of Clinical Immunology and Rheumatology, Department of Medicine, The University of Alabama at Birmingham, 701 South 19th Street, LHRB 473, Birmingham, AL 35294-0007, USA.

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http://dx.doi.org/10.1016/s0047-6374(02)00004-0DOI Listing
April 2002