Publications by authors named "Harshita Agarwal"

6 Publications

  • Page 1 of 1

An epidemic within a pandemic.

Trop Doct 2021 Aug 30:494755211041876. Epub 2021 Aug 30.

Assistant Professor, Department of Trauma & Emergency, AIIMS, Raebareli, India.

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http://dx.doi.org/10.1177/00494755211041876DOI Listing
August 2021

Non-malignant fibroblastic/myofibroblastic tumors in pediatric age group: Clues and pitfalls to the cytological diagnosis.

Cytopathology 2020 03 7;31(2):115-121. Epub 2020 Feb 7.

Department of Paediatric Surgery, Chacha Nehru Bal Chikitsalaya, New Delhi, India.

Introduction: Fibroblastic/myofibroblastic tumors constitute 12% of all pediatric soft tissue tumors with the majority of them belonging to the benign and intermediate prognostic categories. They are often misdiagnosed owing to their variable clinical presentation and unusual microscopic features. The diagnosis, specially cytological diagnosis of benign and intermediate categories is difficult due to paucity of cellular component and increased amount of extracellular matrix as compared to malignant ones. We hereby discuss the Fine needle aspiration cytology (FNAC) findings of non-malignant fibroblastic/myofibroblastic lesion in the pediatric age group encountered at our institute.

Methods: All the benign and intermediate fibroblastic/myofibroblastic/fibroadipocytic lesions (age 0-12 years) diagnosed on FNAC over a period of 3½ years (Jan 2016- July 2019), with availability of corresponding histopathology were included in the study.

Results: A total of seven pediatric benign and intermediate fibroblastic/myofibroblastic lesions with histopathological confirmation were identified which included Infantile digital fibromatosis (IDF) (n = 2), Lipofibromatosis (n = 1), Fibrous hamartoma of infancy (FHI) (n = 1), Fibromatosis colli (FC) (n = 2) and myofibroma/myofibromatosis (n = 1). FNAC smears were mainly paucicellular with presence of benign spindle shaped cells in a collagenous stroma common to almost all the cases. A few additional findings such as degenerated skeletal muscle fibres, muscle giant cells and mature adipose tissue were also present in some cases.

Conclusion: Fibroblastic/myofibroblastic tumors although uncommon, form an important category that must be considered in the differential diagnosis of pediatric soft tissue tumors. FNAC cytology features when assessed in a proper clinical setting (specially the age and site of presentation) are helpful in suggesting probable preoperative diagnosis in these lesions.
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http://dx.doi.org/10.1111/cyt.12786DOI Listing
March 2020

Lipofibromatosis: Clues to the cytological diagnosis of a rare tumour.

Cytopathology 2019 11 1;30(6):667-670. Epub 2019 Aug 1.

Department of Paediatric Surgery, Chacha Nehru Bal Chikitsalaya, New Delhi, India.

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http://dx.doi.org/10.1111/cyt.12749DOI Listing
November 2019

Infantile digital fibromatosis: Clues and pitfalls for cytological diagnosis.

Cytopathology 2019 09 1;30(5):565-566. Epub 2019 Jul 1.

Department of Paediatric Surgery, Chacha Nehru Bal Chikitsalaya, New Delhi, India.

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http://dx.doi.org/10.1111/cyt.12734DOI Listing
September 2019

Ultrasound guided aspirate from a paediatric retroperitoneal mass: A diagnostic dilemma.

Cytopathology 2019 09 23;30(5):560-562. Epub 2019 May 23.

Department of Pathology, Chacha Nehru Bal Chikitsalaya, New Delhi, India.

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http://dx.doi.org/10.1111/cyt.12710DOI Listing
September 2019

Diagnostic utility of GATA3 immunohistochemical expression in urothelial carcinoma.

Indian J Pathol Microbiol 2019 Apr-Jun;62(2):244-250

Department of Pathology, King George Medical University, Lucknow, Uttar Pradesh, India.

Aims: This study aims to explore the utility of GATA binding protein 3, a zinc finger transcription factor, expression in genitourinary carcinoma, especially urothelial carcinoma.

Settings And Design: It is a prospective study where 74 consecutive cases of urothelial carcinoma along with 10 cases each of prostatic adenocarcinoma (PC) and conventional clear cell renal cell carcinoma were included between August 2016 and January 2017.

Methods And Materials: All the cases were histopathologically evaluated and immunohistochemically stained for GATA binding protein 3. Only nuclear positivity was considered as positive. Immunoreactivity score for GATA expression was calculated based on the staining intensity as well as percentage.

Statistical Analysis Used: The statistical analysis was done using Statistical Package for Social Sciences Version 15.0 statistical analysis software. P value of <0.05 was considered statistically significance.

Results: GATA3 expressions were seen in 77% of the cases of urothelial carcinoma, whereas none of the clear cell renal cell carcinoma and prostatic adenocarcinoma cases was GATA3 positive. GATA3 expression significantly correlated with histological grade and muscle invasion with a weaker or negative expression in high-grade muscle invasive tumor as compared to low-grade and noninvasive neoplasm. Significantly weaker expression of GATA3 was found in cases with severe nuclear pleomorphism, mitosis >10/10 hpf, presence of necrosis, and tumor-infiltrating lymphocytes. No significant change in the status of GATA3 expression was seen in follow-up cases between initial Transurethral resection of bladder tumor (TURBT) and post-recurrence TURBT or radical cystectomy specimens.

Conclusions: GATA3 as a sensitive and specific marker for urothelial carcinoma can be effectively used to exclude other genitourinary malignancies, PC, and renal cell carcinoma, at metastatic site. This marker can also be effectively used in predicting the probable grade and invasion in biopsy material with poor morphological characteristics, thereby helping in appropriate management in such cases.
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http://dx.doi.org/10.4103/IJPM.IJPM_228_18DOI Listing
August 2019
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