Publications by authors named "Harry Vrieling"

54Publications

Quantitative phosphoproteomics to unravel the cellular response to chemical stressors with different modes of action.

Arch Toxicol 2020 05 18;94(5):1655-1671. Epub 2020 Mar 18.

Department of Human Genetics, Leiden University Medical Center, P.O. Box 9600, 2300 RC, Leiden, The Netherlands.

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http://dx.doi.org/10.1007/s00204-020-02712-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7261734PMC
May 2020

The functional impact of variants of uncertain significance in BRCA2.

Genet Med 2019 02 10;21(2):293-302. Epub 2018 Jul 10.

Department of Human Genetics, Leiden University Medical Center, PO Box 9600, Leiden, 2300RC, The Netherlands.

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http://dx.doi.org/10.1038/s41436-018-0052-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6752316PMC
February 2019

Hypomorphic Missense Variants Confer Moderate Risks of Breast Cancer.

Authors:
Hermela Shimelis Romy L S Mesman Catharina Von Nicolai Asa Ehlen Lucia Guidugli Charlotte Martin Fabienne M G R Calléja Huong Meeks Emily Hallberg Jamie Hinton Jenna Lilyquist Chunling Hu Cora M Aalfs Kristiina Aittomäki Irene Andrulis Hoda Anton-Culver Volker Arndt Matthias W Beckmann Javier Benitez Natalia V Bogdanova Stig E Bojesen Manjeet K Bolla Anne-Lise Borresen-Dale Hiltrud Brauch Paul Brennan Hermann Brenner Annegien Broeks Barbara Brouwers Thomas Brüning Barbara Burwinkel Jenny Chang-Claude Georgia Chenevix-Trench Ching-Yu Cheng Ji-Yeob Choi J Margriet Collée Angela Cox Simon S Cross Kamila Czene Hatef Darabi Joe Dennis Thilo Dörk Isabel Dos-Santos-Silva Alison M Dunning Peter A Fasching Jonine Figueroa Henrik Flyger Montserrat García-Closas Graham G Giles Gord Glendon Pascal Guénel Christopher A Haiman Per Hall Ute Hamann Mikael Hartman Frans B Hogervorst Antoinette Hollestelle John L Hopper Hidemi Ito Anna Jakubowska Daehee Kang Veli-Matti Kosma Vessela Kristensen Kah-Nyin Lai Diether Lambrechts Loic Le Marchand Jingmei Li Annika Lindblom Artitaya Lophatananon Jan Lubinski Eva Machackova Arto Mannermaa Sara Margolin Frederik Marme Keitaro Matsuo Hui Miao Kyriaki Michailidou Roger L Milne Kenneth Muir Susan L Neuhausen Heli Nevanlinna Janet E Olson Curtis Olswold Jan J C Oosterwijk Ana Osorio Paolo Peterlongo Julian Peto Paul D P Pharoah Katri Pylkäs Paolo Radice Muhammad Usman Rashid Valerie Rhenius Anja Rudolph Suleeporn Sangrajrang Elinor J Sawyer Marjanka K Schmidt Minouk J Schoemaker Caroline Seynaeve Mitul Shah Chen-Yang Shen Martha Shrubsole Xiao-Ou Shu Susan Slager Melissa C Southey Daniel O Stram Anthony Swerdlow Soo H Teo Ian Tomlinson Diana Torres Thérèse Truong Christi J van Asperen Lizet E van der Kolk Qin Wang Robert Winqvist Anna H Wu Jyh-Cherng Yu Wei Zheng Ying Zheng Jennifer Leary Logan Walker Lenka Foretova Florentia Fostira Kathleen B M Claes Liliana Varesco Setareh Moghadasi Douglas F Easton Amanda Spurdle Peter Devilee Harry Vrieling Alvaro N A Monteiro David E Goldgar Aura Carreira Maaike P G Vreeswijk Fergus J Couch

Cancer Res 2017 06 10;77(11):2789-2799. Epub 2017 Mar 10.

Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota.

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http://dx.doi.org/10.1158/0008-5472.CAN-16-2568DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5508554PMC
June 2017

Prostate Cancer Patients with Late Radiation Toxicity Exhibit Reduced Expression of Genes Involved in DNA Double-Strand Break Repair and Homologous Recombination.

Cancer Res 2017 03 20;77(6):1485-1491. Epub 2017 Jan 20.

Laboratory for Experimental Oncology and Radiobiology (LEXOR), Center for Molecular Medicine (CEMM), Department of Radiation Oncology, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.

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http://dx.doi.org/10.1158/0008-5472.CAN-16-1966DOI Listing
March 2017

Xenobiotic metabolism in differentiated human bronchial epithelial cells.

Arch Toxicol 2017 May 13;91(5):2093-2105. Epub 2016 Oct 13.

Department of Human Genetics, Leiden University Medical Center, Postal Zone S4-P, PO Box 9600, 2300 RC, Leiden, The Netherlands.

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http://dx.doi.org/10.1007/s00204-016-1868-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5399058PMC
May 2017

Activation of the Nrf2 response by intrinsic hepatotoxic drugs correlates with suppression of NF-κB activation and sensitizes toward TNFα-induced cytotoxicity.

Arch Toxicol 2016 May 31;90(5):1163-79. Epub 2015 May 31.

Division of Toxicology, Leiden Academic Center for Drug Research, Leiden University, Einsteinweg 55, 2333 CC, Leiden, The Netherlands.

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http://dx.doi.org/10.1007/s00204-015-1536-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4830895PMC
May 2016

Mechanism-based genotoxicity screening of metal oxide nanoparticles using the ToxTracker panel of reporter cell lines.

Part Fibre Toxicol 2014 Sep 2;11:41. Epub 2014 Sep 2.

Nanosafety & Nanomedicine Laboratory, Division of Molecular Toxicology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.

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http://particleandfibretoxicology.biomedcentral.com/articles
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http://dx.doi.org/10.1186/s12989-014-0041-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4237954PMC
September 2014

Quantitative high content imaging of cellular adaptive stress response pathways in toxicity for chemical safety assessment.

Chem Res Toxicol 2014 Mar 5;27(3):338-55. Epub 2014 Feb 5.

Division of Toxicology, Leiden Academic Centre for Drug Research (LACDR), Leiden University , The Netherlands.

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http://pubs.acs.org/doi/10.1021/tx4004038
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http://dx.doi.org/10.1021/tx4004038DOI Listing
March 2014

Reduced activity of double-strand break repair genes in prostate cancer patients with late normal tissue radiation toxicity.

Int J Radiat Oncol Biol Phys 2014 Mar 8;88(3):664-70. Epub 2014 Jan 8.

Laboratory for Experimental Oncology and Radiobiology (LEXOR), Center for Molecular Medicine (CEMM), Department of Radiation Oncology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.ijrobp.2013.11.219DOI Listing
March 2014

Systems biology approach identifies the kinase Csnk1a1 as a regulator of the DNA damage response in embryonic stem cells.

Sci Signal 2013 Jan 22;6(259):ra5. Epub 2013 Jan 22.

Division of Toxicology, Leiden/Amsterdam Center for Drug Research, Leiden University, P. O. Box 9502, 2300 RA Leiden, The Netherlands.

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http://dx.doi.org/10.1126/scisignal.2003208DOI Listing
January 2013

Cellular-signaling pathways unveil the carcinogenic potential of chemicals.

J Appl Toxicol 2013 Jun 22;33(6):399-409. Epub 2013 Jan 22.

Department of Toxicogenetics, Leiden University Medical Center, PO Box 9600, 2300, RC, Leiden, The Netherlands.

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http://dx.doi.org/10.1002/jat.2845DOI Listing
June 2013

No threshold for the induction of chromosomal damage at clinically relevant low doses of X rays.

Radiat Res 2012 May 2;177(5):602-13. Epub 2012 Apr 2.

aDepartment of Toxicogenetics, Leiden University Medical Center, 2300 RC Leiden, The Netherlands.

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http://dx.doi.org/10.1667/rr2718.1DOI Listing
May 2012

Sensitive DsRed fluorescence-based reporter cell systems for genotoxicity and oxidative stress assessment.

Mutat Res 2011 May 4;709-710:49-59. Epub 2011 Mar 4.

Department of Toxicogenetics, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands.

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http://dx.doi.org/10.1016/j.mrfmmm.2011.02.013DOI Listing
May 2011

Finding transcriptomics biomarkers for in vivo identification of (non-)genotoxic carcinogens using wild-type and Xpa/p53 mutant mouse models.

Carcinogenesis 2009 Oct 20;30(10):1805-12. Epub 2009 Aug 20.

MicroArray Department and Integrative Bioinformatics Unit, Swammerdam Institute for Life Sciences, Faculty of Science, University of Amsterdam, Amsterdam, The Netherlands.

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http://carcin.oxfordjournals.org/content/30/10/1805.full.pdf
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http://www.carcin.oxfordjournals.org/cgi/doi/10.1093/carcin/
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http://dx.doi.org/10.1093/carcin/bgp190DOI Listing
October 2009

Differential activity of UV-DDB in mouse keratinocytes and fibroblasts: impact on DNA repair and UV-induced skin cancer.

DNA Repair (Amst) 2009 Feb 4;8(2):153-61. Epub 2008 Dec 4.

Department of Toxicogenetics, Leiden University Medical Center, P.O. Box 9600, 2300 RC Leiden, The Netherlands.

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http://dx.doi.org/10.1016/j.dnarep.2008.09.011DOI Listing
February 2009

Cell-type-specific consequences of nucleotide excision repair deficiencies: Embryonic stem cells versus fibroblasts.

DNA Repair (Amst) 2008 Oct 26;7(10):1659-69. Epub 2008 Jul 26.

MGC, Department of Genetics, Erasmus University Medical Center, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.dnarep.2008.06.009DOI Listing
October 2008

Gene transcription increases DNA damage-induced mutagenesis in mammalian stem cells.

DNA Repair (Amst) 2008 Aug 9;7(8):1330-9. Epub 2008 Jun 9.

Department of Toxicogenetics, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1016/j.dnarep.2008.04.015DOI Listing
August 2008

Nucleotide excision repair in differentiated cells.

Mutat Res 2007 Jan 1;614(1-2):16-23. Epub 2006 Aug 1.

Department of Toxicogenetics, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1016/j.mrfmmm.2006.06.005DOI Listing
January 2007

Enhanced DDB2 expression protects mice from carcinogenic effects of chronic UV-B irradiation.

Cancer Res 2005 Nov;65(22):10298-306

Department of Toxicogenetics, Leiden University Medical Center, Leiden University, Leiden, the Netherlands.

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http://dx.doi.org/10.1158/0008-5472.CAN-05-2295DOI Listing
November 2005

Dissecting systems-wide data using mixture models: application to identify affected cellular processes.

BMC Bioinformatics 2005 Jul 14;6:177. Epub 2005 Jul 14.

Department of Toxicogenetics, Leiden University Medical Centre, P.O. Box 9503, 2300 RA Leiden, The Netherlands.

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http://dx.doi.org/10.1186/1471-2105-6-177DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1189081PMC
July 2005

Transcription-coupled repair: impact on UV-induced mutagenesis in cultured rodent cells and mouse skin tumors.

Mutat Res 2005 Sep;577(1-2):170-8

Department of Toxicogenetics, Leiden University Medical Center, Wassenaarseweg 72, 2333 AL Leiden, The Netherlands.

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http://linkinghub.elsevier.com/retrieve/pii/S002751070500179
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http://dx.doi.org/10.1016/j.mrfmmm.2005.03.018DOI Listing
September 2005

A novel regulation mechanism of DNA repair by damage-induced and RAD23-dependent stabilization of xeroderma pigmentosum group C protein.

Genes Dev 2003 Jul 18;17(13):1630-45. Epub 2003 Jun 18.

MGC-Department of Cell Biology & Genetics, Centre for Biomedical Genetics, Erasmus Medical Center, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1101/gad.260003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC196135PMC
July 2003

Chemical carcinogens induce varying patterns of LOH in mouse T-lymphocytes.

Carcinogenesis 2003 Jan;24(1):139-44

Department of Radiation Genetics and Chemical Mutagenesis - MGC, Leiden University Medical Center, PO Box 9503, 2300 RA Leiden,The Netherlands.

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http://dx.doi.org/10.1093/carcin/24.1.139DOI Listing
January 2003