Harry Scheinin

Harry Scheinin

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Harry Scheinin

Harry Scheinin

Publications by authors named "Harry Scheinin"

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Single-subject analysis of N400 event-related potential component with five different methods.

Int J Psychophysiol 2019 Oct 19;144:14-24. Epub 2019 Jun 19.

Department of Psychology and Speech-Language Pathology, and Turku Brain and Mind Center, University of Turku, Turku, Finland; Department of Perioperative Services, Intensive Care and Pain Medicine, Turku University Hospital, Turku, Finland; Department of Cognitive Neuroscience and Philosophy, University of Skövde, Skövde, Sweden.

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http://dx.doi.org/10.1016/j.ijpsycho.2019.06.012DOI Listing
October 2019

Using Positron Emission Tomography in Revealing the Mystery of General Anesthesia: Study Design Challenges and Opportunities.

Methods Enzymol 2018 9;603:279-303. Epub 2018 Mar 9.

Turku PET Centre, University of Turku and the Hospital District of Southwest Finland, Turku, Finland; Tampere University Hospital, Tampere, Finland.

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http://dx.doi.org/10.1016/bs.mie.2018.01.025DOI Listing
March 2019

Differentiating Drug-related and State-related Effects of Dexmedetomidine and Propofol on the Electroencephalogram.

Anesthesiology 2018 07;129(1):22-36

From the Turku PET Centre, University of Turku and the Hospital District of Southwest Finland, Turku, Finland (A.S., K.K., J.L., A.M., H.S.) the Department of Perioperative Services, Intensive Care and Pain Medicine, Turku University Hospital, Turku, Finland (A.S., R.E.K., M.K., A.M., H.S.) the Department of Psychology and Speech-Language Pathology, and Turku Brain and Mind Center (R.E.K., K.V., A.R.) the Department of Pharmacology, Drug Development and Therapeutics (H.S.) University of Turku, Turku, Finland; the Department of Anesthesiology, Center for Consciousness Science, University of Michigan Medical School, Ann Arbor, Michigan (D.L., G.A.M.) the Department of Anesthesiology and Intensive Care, Oulu University Hospital, Oulu, Finland (K.K.) the Department of Intensive Care, Tampere University Hospital, Tampere, Finland (J.L.) the Department of Clinical Medicine, Biostatistics, University of Turku and Turku University Hospital, Turku, Finland (T.V.) the Department of Cognitive Neuroscience and Philosophy, School of Bioscience, University of Skövde, Skövde, Sweden (K.V., A.R.).

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http://dx.doi.org/10.1097/ALN.0000000000002192DOI Listing
July 2018

Inhaled Xenon Attenuates Myocardial Damage in Comatose Survivors of Out-of-Hospital Cardiac Arrest: The Xe-Hypotheca Trial.

J Am Coll Cardiol 2017 Nov;70(21):2652-2660

Division of Perioperative Services, Intensive Care Medicine and Pain Management, Turku University Hospital, University of Turku, Turku, Finland. Electronic address:

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http://dx.doi.org/10.1016/j.jacc.2017.09.1088DOI Listing
November 2017

Detecting a dexmedetomidine-evoked reduction of noradrenaline release in the human brain with the alpha2C-adrenoceptor PET ligand [11C]ORM-13070.

Synapse 2016 Feb 26;70(2):57-65. Epub 2015 Nov 26.

Department of Pharmacology, Drug Development and Therapeutics, University of Turku, Turku, Finland.

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http://dx.doi.org/10.1002/syn.21872DOI Listing
February 2016

Directional connectivity between frontal and posterior brain regions is altered with increasing concentrations of propofol.

PLoS One 2014 24;9(11):e113616. Epub 2014 Nov 24.

Turku PET Centre, University of Turku, Turku, Finland; Department of Pharmacology, Drug Development and Therapeutics, University of Turku, Turku, Finland.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0113616PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4242654PMC
January 2016

[Is it possible to measure the depth of anesthesia using electroencephalogram?].

Duodecim 2015 ;131(20):1929-36

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January 2016

Sensitivity of [(11)C]ORM-13070 to increased extracellular noradrenaline in the CNS - a PET study in human subjects.

Psychopharmacology (Berl) 2015 Nov 29;232(21-22):4169-78. Epub 2015 Apr 29.

Department of Pharmacology, Drug Development and Therapeutics, University of Turku, Turku, Finland.

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http://dx.doi.org/10.1007/s00213-015-3941-yDOI Listing
November 2015

Harnessing anesthesia and brain imaging for the study of human consciousness.

Curr Pharm Des 2014 ;20(26):4211-24

Intensive Care Unit, Tampere University Hospital, Central Hospital, Teiskontie 35, P.O. Box 2000, FI- 33521 Tampere, Finland.

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March 2015

Intravenous ethanol increases dopamine release in the ventral striatum in humans: PET study using bolus-plus-infusion administration of [(11)C]raclopride.

J Cereb Blood Flow Metab 2015 Mar 10;35(3):424-31. Epub 2014 Dec 10.

1] Turku PET Centre, University of Turku, Turku, Finland [2] Department of Pharmacology, Drug Development and Therapeutics, University of Turku, Turku, Finland.

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http://dx.doi.org/10.1038/jcbfm.2014.209DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4348378PMC
March 2015

Validation of [(11) C]ORM-13070 as a PET tracer for alpha2c -adrenoceptors in the human brain.

Synapse 2015 Mar 8;69(3):172-81. Epub 2015 Jan 8.

Department of Pharmacology, Drug Development and Therapeutics, University of Turku, Turku, Finland; Clinical Research Services Turku CRST, Turku, Finland; Unit of Clinical Pharmacology, Turku University Hospital, Turku, Finland.

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http://dx.doi.org/10.1002/syn.21798DOI Listing
March 2015

Sleep apnoea is associated with major cardiac events in peripheral arterial disease.

Eur Respir J 2014 Jun 20;43(6):1652-60. Epub 2014 Feb 20.

Division of Perioperative Services, Intensive Care Medicine and Pain Management, Turku University Hospital, Turku

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http://dx.doi.org/10.1183/09031936.00130913DOI Listing
June 2014

Feasibility and cardiac safety of inhaled xenon in combination with therapeutic hypothermia following out-of-hospital cardiac arrest.

Crit Care Med 2013 Sep;41(9):2116-24

Perioperative Services, Intensive Care Medicine and Pain Management, Turku University Hospital, University of Turku, Turku, Finland.

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http://dx.doi.org/10.1097/CCM.0b013e31828a4337DOI Listing
September 2013

Why does bispectral index monitoring not perform better?

Anesthesiology 2013 May;118(5):1233-4

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http://dx.doi.org/10.1097/ALN.0b013e318289b936DOI Listing
May 2013

Heart rate variability dynamics during low-dose propofol and dexmedetomidine anesthesia.

Ann Biomed Eng 2012 Aug 15;40(8):1802-13. Epub 2012 Mar 15.

Department of Applied Physics, University of Eastern Finland, P.O. Box 1627, 70211 Kuopio, Finland.

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http://dx.doi.org/10.1007/s10439-012-0544-1DOI Listing
August 2012

Striatal μ-opioid receptor availability predicts cold pressor pain threshold in healthy human subjects.

Neurosci Lett 2012 Jul 20;521(1):11-4. Epub 2012 May 20.

Pain Clinic and Department of Anaesthesiology, Intensive Care, Emergency Care and Pain Medicine, Turku University Hospital, Turku, Finland.

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http://dx.doi.org/10.1016/j.neulet.2012.05.042DOI Listing
July 2012

Consciousness lost and found: subjective experiences in an unresponsive state.

Brain Cogn 2011 Dec 8;77(3):327-34. Epub 2011 Oct 8.

Centre for Cognitive Neuroscience, Department of Psychology, University of Turku, 20014 Turku, Finland.

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http://dx.doi.org/10.1016/j.bandc.2011.09.002DOI Listing
December 2011

Renal effects of dexmedetomidine during coronary artery bypass surgery: a randomized placebo-controlled study.

BMC Anesthesiol 2011 May 23;11. Epub 2011 May 23.

Department of Anaesthesiology, Intensive Care, Emergency Care and Pain Medicine, Turku University Hospital, Turku, Finland.

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http://dx.doi.org/10.1186/1471-2253-11-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3123640PMC
May 2011

Delta entropy of heart rate variability along with deepening anesthesia.

Anesth Analg 2011 Mar 13;112(3):587-92. Epub 2011 Jan 13.

Department of Anaesthesiology, Intensive Care, Emergency Care and Pain Medicine, Turku University Hospital, Hietalahdenkatu 1 a 5 FIN-65100 Vaasa, Finland.

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http://dx.doi.org/10.1213/ANE.0b013e318208074dDOI Listing
March 2011

C957T polymorphism of the human dopamine D2 receptor gene predicts extrastriatal dopamine receptor availability in vivo.

Prog Neuropsychopharmacol Biol Psychiatry 2009 Jun 11;33(4):630-6. Epub 2009 Mar 11.

Department of Pharmacology, Drug Development and Therapeutics, University of Turku, 20014 Turku, Finland.

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https://linkinghub.elsevier.com/retrieve/pii/S02785846090006
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http://dx.doi.org/10.1016/j.pnpbp.2009.02.021DOI Listing
June 2009

Measurement of central mu-opioid receptor binding in vivo with PET and [11C]carfentanil: a test-retest study in healthy subjects.

Eur J Nucl Med Mol Imaging 2009 Feb 9;36(2):275-86. Epub 2008 Sep 9.

Turku PET Centre, University of Turku and Turku University Central Hospital, Turku, Finland.

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http://dx.doi.org/10.1007/s00259-008-0935-6DOI Listing
February 2009

Measurement of GABAA receptor binding in vivo with [11C]flumazenil: a test-retest study in healthy subjects.

Neuroimage 2008 Jun 4;41(2):260-9. Epub 2008 Mar 4.

Turku PET Centre, University of Turku and Department of Otorhinolaryngology--Head and Neck Surgery, Turku University Hospital, Finland.

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http://linkinghub.elsevier.com/retrieve/pii/S105381190800191
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http://dx.doi.org/10.1016/j.neuroimage.2008.02.035DOI Listing
June 2008

Bispectral index, entropy, and quantitative electroencephalogram during single-agent xenon anesthesia.

Anesthesiology 2008 Jan;108(1):63-70

Turku Positron Emission Tomography (PET) Centre, and Department of Anesthesiology and Intensive Care, Turku University Hospital, Turku, Finland.

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http://dx.doi.org/10.1097/01.anes.0000296106.52472.a6DOI Listing
January 2008

The role of heart rate variability in risk stratification for adverse postoperative cardiac events.

Anesth Analg 2007 Dec;105(6):1548-60

Department of Anesthesiology and Intensive Care, Turku University Hospital, Turku, Finland.

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http://dx.doi.org/10.1213/01.ane.0000287654.49358.3aDOI Listing
December 2007

Effects of xenon anesthesia on cerebral blood flow in humans: a positron emission tomography study.

Anesthesiology 2007 Jun;106(6):1128-33

Turku PET Centre, Department of Anesthesiology and Intensive Care, Turku University Hospital, Finland.

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http://dx.doi.org/10.1097/01.anes.0000267596.57497.92DOI Listing
June 2007

Effects of low and high plasma concentrations of dexmedetomidine on myocardial perfusion and cardiac function in healthy male subjects.

Anesthesiology 2006 Nov;105(5):902-10; quiz 1069-70

Department of Pharmacology, Drug Development and Therapeutics, University of Turku, Itäinen Pitkäkatu 4B, FI-20520 Turku, Finland.

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http://dx.doi.org/10.1097/00000542-200611000-00010DOI Listing
November 2006

Long-term alterations of heart rate dynamics after coronary artery bypass graft surgery.

Anesth Analg 2006 Apr;102(4):1026-31

Department of Anesthesiology and Intensive Care, Turku University Hospital, Turku, Finland.

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http://dx.doi.org/10.1213/01.ane.0000198674.90500.59DOI Listing
April 2006

Prolonged central mu-opioid receptor occupancy after single and repeated nalmefene dosing.

Neuropsychopharmacology 2005 Dec;30(12):2245-53

Clinical Research Services Turku (CRST), University of Turku, FIN-20521 Turku, Finland.

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http://dx.doi.org/10.1038/sj.npp.1300790DOI Listing
December 2005

Cortical glutamate-dopamine interaction and ketamine-induced psychotic symptoms in man.

Psychopharmacology (Berl) 2005 Nov 19;182(3):375-83. Epub 2005 Oct 19.

Turku PET Centre, University of Turku, 20520, Turku, Finland.

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http://dx.doi.org/10.1007/s00213-005-0092-6DOI Listing
November 2005

Subanesthetic ketamine does not affect 11C-flumazenil binding in humans.

Anesth Analg 2005 Sep;101(3):722-5, table of contents

Turku PET Centre, PO Box 52, FIN-20521 Turku, Finland.

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http://dx.doi.org/10.1213/01.ANE.0000156951.83242.8DDOI Listing
September 2005

Analysis of rapid heart rate variability in the assessment of anticholinergic drug effects in humans.

Eur J Clin Pharmacol 2005 Sep 30;61(8):559-65. Epub 2005 Aug 30.

Department of Pharmacology and Clinical Pharmacology, University of Turku, Turku, Finland.

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http://dx.doi.org/10.1007/s00228-005-0953-2DOI Listing
September 2005

Sevoflurane and propofol increase 11C-flumazenil binding to gamma-aminobutyric acidA receptors in humans.

Anesth Analg 2004 Nov;99(5):1420-6; table of contents

Turku PET Centre, Turku University Hospital, PO Box 52, FIN-20521 Turku, Finland.

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http://dx.doi.org/10.1213/01.ANE.0000135409.81842.31DOI Listing
November 2004

Striatal dopamine D2 receptors in modulation of pain in humans: a review.

Eur J Pharmacol 2004 Oct;500(1-3):187-92

Turku PET Centre, Turku University Central Hospital and University of Turku, 20520 Turku, Finland.

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http://dx.doi.org/10.1016/j.ejphar.2004.07.024DOI Listing
October 2004

Striatal dopamine D2/D3 receptor availability correlates with individual response characteristics to pain.

Eur J Neurosci 2004 Sep;20(6):1587-92

Department of Physiology, Institute of Biomedicine, University of Turku, Jiinamyllynkatu 10, FIN-20520 Turku, Finland.

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http://doi.wiley.com/10.1111/j.1460-9568.2004.03622.x
Publisher Site
http://dx.doi.org/10.1111/j.1460-9568.2004.03622.xDOI Listing
September 2004

Ventilator add-on for delivering PET tracer gases.

J Nucl Med Technol 2004 Jun;32(2):79-82

Department of Anesthesiology and Intensive Care, and Turku PET Centre, Turku University Hospital, PO Box 52, FIN-20521 Turku, Finland.

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June 2004

Alfentanil increases cortical dopamine D2/D3 receptor binding in healthy subjects.

Pain 2004 May;109(1-2):86-93

Turku PET Centre, University of Turku, P.O. Box 52, FIN 20521 Turku, Finland.

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http://dx.doi.org/10.1016/j.pain.2004.01.013DOI Listing
May 2004

The breakdown of fractal heart rate dynamics predicts prolonged postoperative myocardial ischemia.

Anesth Analg 2004 May;98(5):1239-44, table of contents

Department of Anesthesiology and Intensive Care, Turku University Hospital, Turku, Finland.

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http://pdfs.journals.lww.com/anesthesia-analgesia/2004/05000
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May 2004

Effects of subanesthetic ketamine on regional cerebral glucose metabolism in humans.

Anesthesiology 2004 May;100(5):1065-71

Turku PET Centre, University of Turku, and the Department of Anesthesiology and Intensive Care, Turku University Hospital, Turku, Finland.

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http://dx.doi.org/10.1097/00000542-200405000-00006DOI Listing
May 2004

Cardiovascular and parasympathetic effects of dexmedetomidine in healthy subjects.

Can J Physiol Pharmacol 2004 May;82(5):359-62

Department of Pharmacology and Clinical Pharmacology, University of Turku, Finland.

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http://dx.doi.org/10.1139/y04-028DOI Listing
May 2004

Effect of the novel anxiolytic drug deramciclane on cytochrome P(450) 2D6 activity as measured by desipramine pharmacokinetics.

Eur J Clin Pharmacol 2004 Feb 17;59(12):893-8. Epub 2004 Jan 17.

Department of Pharmacology and Clinical Pharmacology, University of Turku, It. Pitkäkatu 4B, 20520 Turku, Finland.

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http://dx.doi.org/10.1007/s00228-003-0714-zDOI Listing
February 2004

Altered dopamine D2 receptor binding in atypical facial pain.

Pain 2003 Nov;106(1-2):43-8

Department of Anesthesiology and Intensive Care, Turku University Central Hospital, P.O. Box 52, FIN-20521 Turku, Finland.

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http://dx.doi.org/10.1016/s0304-3959(03)00275-6DOI Listing
November 2003

Striatal dopamine D1 and D2 receptors in burning mouth syndrome.

Pain 2003 Jan;101(1-2):149-54

Department of Anesthesiology and Intensive Care, Turku University Central Hospital, PO Box 52, FIN-20521, Turku, Finland.

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http://dx.doi.org/10.1016/s0304-3959(02)00323-8DOI Listing
January 2003

Ketamine does not decrease striatal dopamine D2 receptor binding in man.

Psychopharmacology (Berl) 2002 Dec 12;164(4):401-6. Epub 2002 Oct 12.

Neuropsychiatric Imaging, Turku PET Centre, Turku University Central Hospital, Kiinamyllynkatu 4-8, 20520 Turku, Finland.

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http://dx.doi.org/10.1007/s00213-002-1236-6DOI Listing
December 2002

Mu-receptor agonism with alfentanil increases striatal dopamine D2 receptor binding in man.

Synapse 2002 Jul;45(1):25-30

Department of Anesthesiology and Intensive Care, Turku University Central Hospital, Turku, Finland.

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http://dx.doi.org/10.1002/syn.10078DOI Listing
July 2002