Harry L T Mobley

The Gene Expression Profile of Uropathogenic Escherichia coli in Women with Uncomplicated Urinary Tract Infections Is Recapitulated in the Mouse Model.

Authors:

Arwen E Frick-Cheng Anna Sintsova Sara N Smith Michael Krauthammer Kathryn A Eaton Harry L T Mobley

mBio 2020 08 11;11(4). Epub 2020 Aug 11.

Department of Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan, USA

View Article and Find Full Text PDF

August 2020

MrpH, a new class of metal-binding adhesin, requires zinc to mediate biofilm formation.

Authors:

Wangshu Jiang Wimal Ubhayasekera Michael C Breed Allison N Norsworthy Nina Serr Harry L T Mobley Melanie M Pearson Stefan D Knight

PLoS Pathog 2020 08 11;16(8):e1008707. Epub 2020 Aug 11.

Department of Cell and Molecular Biology, Uppsala University, Biomedical Center, Uppsala, Sweden.

View Article and Find Full Text PDF

August 2020

Transposon Insertion Site Sequencing of Providencia stuartii: Essential Genes, Fitness Factors for Catheter-Associated Urinary Tract Infection, and the Impact of Polymicrobial Infection on Fitness Requirements.

Authors:

Alexandra O Johnson Valerie Forsyth Sara N Smith Brian S Learman Aimee L Brauer Ashley N White Lili Zhao Weisheng Wu Harry L T Mobley Chelsie E Armbruster

mSphere 2020 05 27;5(3). Epub 2020 May 27.

Department of Microbiology and Immunology, Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, New York, USA

View Article and Find Full Text PDF

May 2020

The Serratia marcescens Siderophore Serratiochelin Is Necessary for Full Virulence during Bloodstream Infection.

Authors:

Danelle R Weakland Sara N Smith Bailey Bell Ashootosh Tripathi Harry L T Mobley

Infect Immun 2020 Jul 21;88(8). Epub 2020 Jul 21.

University of Michigan Medical School, Department of Microbiology and Immunology, Ann Arbor, Michigan, USA

View Article and Find Full Text PDF

July 2020

Escherichia coli CFT073 Fitness Factors during Urinary Tract Infection: Identification Using an Ordered Transposon Library.

Authors:

Allyson E Shea Juan Marzoa Stephanie D Himpsl Sara N Smith Lili Zhao Lisa Tran Harry L T Mobley

Appl Environ Microbiol 2020 06 17;86(13). Epub 2020 Jun 17.

Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan, USA

View Article and Find Full Text PDF

June 2020

Optimization of an Experimental Vaccine To Prevent Escherichia coli Urinary Tract Infection.

Authors:

Valerie S Forsyth Stephanie D Himpsl Sara N Smith Christina A Sarkissian Laura A Mike Jolie A Stocki Anna Sintsova Christopher J Alteri Harry L T Mobley

mBio 2020 04 28;11(2). Epub 2020 Apr 28.

Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan, USA

View Article and Find Full Text PDF

April 2020

The oxidative fumarase FumC is a key contributor for E. coli fitness under iron-limitation and during UTI.

Authors:

Stephanie D Himpsl Allyson E Shea Jonathan Zora Jolie A Stocki Dannielle Foreman Christopher J Alteri Harry L T Mobley

PLoS Pathog 2020 02 27;16(2):e1008382. Epub 2020 Feb 27.

Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan, United States of America.

View Article and Find Full Text PDF

February 2020

Dietary L-serine confers a competitive fitness advantage to Enterobacteriaceae in the inflamed gut.

Nat Microbiol 2020 01 4;5(1):116-125. Epub 2019 Nov 4.

Division of Gastroenterology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.

View Article and Find Full Text PDF

January 2020

The UDP-GalNAcA biosynthesis genes gna-gne2 are required to maintain cell envelope integrity and in vivo fitness in multi-drug resistant Acinetobacter baumannii.

Authors:

Sébastien Crépin Elizabeth N Ottosen Courtney E Chandler Anna Sintsova Robert K Ernst Harry L T Mobley

Mol Microbiol 2020 01 19;113(1):153-172. Epub 2019 Nov 19.

Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI, USA.

View Article and Find Full Text PDF

January 2020

The Klebsiella pneumoniae citrate synthase gene, gltA, influences site specific fitness during infection.

Authors:

Jay Vornhagen Yuang Sun Paul Breen Valerie Forsyth Lili Zhao Harry L T Mobley Michael A Bachman

PLoS Pathog 2019 08 26;15(8):e1008010. Epub 2019 Aug 26.

Department of Pathology, University of Michigan, Ann Arbor, United States of America.

View Article and Find Full Text PDF

August 2019

Sulfur Assimilation Alters Flagellar Function and Modulates the Gene Expression Landscape of Serratia marcescens.

Authors:

Mark T Anderson Lindsay A Mitchell Anna Sintsova Katherine A Rice Harry L T Mobley

mSystems 2019 Aug 6;4(4). Epub 2019 Aug 6.

Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan, USA

View Article and Find Full Text PDF

August 2019

UTI patients have pre-existing antigen-specific antibody titers against UTI vaccine antigens.

Authors:

Christina A Sarkissian Christopher J Alteri Harry L T Mobley

Vaccine 2019 08 15;37(35):4937-4946. Epub 2019 Jul 15.

Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI, USA. Electronic address:

View Article and Find Full Text PDF

August 2019

Transposon Insertion Site Sequencing in a Urinary Tract Model.

Authors:

Valerie S Forsyth Harry L T Mobley Chelsie E Armbruster

Methods Mol Biol 2019 ;2021:297-337

Department of Microbiology and Immunology, Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, NY, USA.

View Article and Find Full Text PDF

March 2020