Publications by authors named "Harry L A Janssen"

100Publications

Analysis of Hepatitis B virus haplotype diversity detects striking sequence conservation across genotypes and chronic disease phase.

Hepatology 2020 Aug 11. Epub 2020 Aug 11.

Division of Molecular Research and Development, Victorian Infectious Diseases Reference Laboratory, Peter Doherty Institute for Infection and Immunity, Melbourne Healthy, University of Melbourne, Melbourne, Australia.

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http://dx.doi.org/10.1002/hep.31516DOI Listing
August 2020

Reducing Read Time of Point of Care Test Does Not Affect Detection of Hepatitis C Virus and Reduces Need for Reflex RNA.

Clin Gastroenterol Hepatol 2020 Aug 4. Epub 2020 Aug 4.

Viral Hepatitis Care Network (VIRCAN), Toronto, ON, Canada; Toronto Centre for Liver Disease, University Health Network, University of Toronto, Toronto, ON, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.cgh.2020.07.058DOI Listing
August 2020

Reply to Letter to the Editor: Stopping nucleos(t)ide analogue therapy in HBeAg-negative chronic hepatitis B (GASTRO-D-19-02940).

Gastroenterology 2020 Jul 18. Epub 2020 Jul 18.

Toronto Centre for Liver Disease, Toronto General Hospital, University Health Network, Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2020.07.031DOI Listing
July 2020

Optimized ex vivo stimulation identifies multi-functional HBV-specific T cells in a majority of chronic hepatitis B patients.

Sci Rep 2020 Jul 9;10(1):11344. Epub 2020 Jul 9.

Toronto Centre for Liver Disease, Toronto General Hospital Research Institute, University Health Network, Toronto, Canada.

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http://dx.doi.org/10.1038/s41598-020-68226-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7347526PMC
July 2020

Spontaneous Clearance After Relapse Following Direct-Acting Antiviral Treatment for Chronic HCV Infection.

Clin Gastroenterol Hepatol 2020 Jul 3. Epub 2020 Jul 3.

Toronto Centre for Liver Disease, Toronto General Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada; Toronto Viral Hepatitis Care Network, Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.cgh.2020.06.061DOI Listing
July 2020

Association Between Seroclearance of Hepatitis B Surface Antigen and Long-term Clinical Outcomes of Patients With Chronic HBV Infection: Systematic Review and Meta-analysis.

Clin Gastroenterol Hepatol 2020 May 27. Epub 2020 May 27.

Senior Biostatistician, Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.cgh.2020.05.041DOI Listing
May 2020

Adherence to a plant-based, high-fibre dietary pattern is related to regression of non-alcoholic fatty liver disease in an elderly population.

Eur J Epidemiol 2020 Apr 22. Epub 2020 Apr 22.

Department of Epidemiology, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1007/s10654-020-00627-2DOI Listing
April 2020

Patient Knowledge, Beliefs and Barriers to Hepatitis B Care: Results of a Multicenter, Multiethnic Patient Survey.

Dig Dis Sci 2020 Apr 1. Epub 2020 Apr 1.

Division of Gastroenterology and Hepatology, Department of Medicine, University of California San Francisco, Zuckerberg San Francisco General Hospital, 1001 Potrero Ave., Building 5, Suite 3D, Ward 3D-4, San Francisco, CA, 94110, USA.

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http://dx.doi.org/10.1007/s10620-020-06224-3DOI Listing
April 2020

Alcohol, tobacco and coffee consumption and liver disease severity among individuals with Chronic Hepatitis B infection in North America.

Ann Hepatol 2020 Jul - Aug;19(4):437-445. Epub 2020 Feb 8.

Division of Gastroenterology, Toronto General Hospital, University Health Network, Toronto, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.aohep.2020.01.005DOI Listing
February 2020

Serum alanine aminotransferase flares in chronic hepatitis B infection: the good and the bad.

Lancet Gastroenterol Hepatol 2020 04 10;5(4):406-417. Epub 2020 Feb 10.

Toronto Centre for Liver Disease, Toronto General Hospital, University of Toronto, Toronto, ON, Canada. Electronic address:

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http://dx.doi.org/10.1016/S2468-1253(19)30344-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7158588PMC
April 2020

Evaluation of sustained virological response as a relevant surrogate endpoint for long-term outcomes of hepatitis C virus infection.

Clin Infect Dis 2020 Feb 13. Epub 2020 Feb 13.

Toronto Centre for Liver Disease, Toronto General Hospital, University Health Network, Toronto, Canada.

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http://dx.doi.org/10.1093/cid/ciaa144DOI Listing
February 2020

IFN-α Suppresses Myeloid Cytokine Production, Impairing IL-12 Production and the Ability to Support T-Cell Proliferation.

J Infect Dis 2020 Jun;222(1):148-157

Toronto Centre for Liver Disease, Toronto General Hospital Research Institute, University Health Network, Toronto, Canada.

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http://dx.doi.org/10.1093/infdis/jiaa064DOI Listing
June 2020

Liver safety assessment in clinical trials of new agents for chronic hepatitis B.

J Viral Hepat 2020 02 11;27(2):96-109. Epub 2019 Dec 11.

Janssen Research & Development, Janssen Pharmaceutica NV, Beerse, Belgium.

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http://dx.doi.org/10.1111/jvh.13223DOI Listing
February 2020

Challenges With Stopping Long-term Nucleos(t)ide Analogue Therapy in Patients With Chronic Hepatitis B.

Gastroenterology 2020 04 4;158(5):1185-1190. Epub 2019 Dec 4.

Toronto Centre for Liver Disease, Toronto General Hospital, University Health Network, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1053/j.gastro.2019.10.050DOI Listing
April 2020

M2-polarized tumor-associated macrophages promote epithelial-mesenchymal transition via activation of the AKT3/PRAS40 signaling pathway in intrahepatic cholangiocarcinoma.

J Cell Biochem 2020 Apr 6;121(4):2828-2838. Epub 2019 Nov 6.

NHC Key Laboratory of Glycoconjugate Research, Department of Biochemistry and Molecular Biology, Shanghai Medical College, Fudan University, Shanghai, China.

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http://dx.doi.org/10.1002/jcb.29514DOI Listing
April 2020

Epidemiologic and clinical features of chronic hepatitis B virus infection in 8 Canadian provinces: a descriptive study by the Canadian HBV Network.

CMAJ Open 2019 Oct-Dec;7(4):E610-E617. Epub 2019 Oct 22.

Cumming School of Medicine (Coffin, Lethebe, Congly, Haylock-Jacobs), University of Calgary, Calgary, Alta.; Division of Gastroenterology (Ramji, Ko), Department of Medicine, Faculty of Medicine, University of British Columbia, Vancouver, BC; Division of Infectious Diseases (Cooper), University of Ottawa, Ottawa Hospital Research Institute; Division of Gastroenterology (Kelly), Department of Medicine, University of Ottawa, Ottawa Hospital Research Institute, Ottawa, Ont.; Department of Medicine (Doucette, Ma), University of Alberta, Edmonton, Alta.; Division of Gastroenterology (P. Wong), Department of Medicine, McGill University, Royal Victoria Hospital, Montréal, Que.; LAIR Centre (Tam), Vancouver, BC; Department of Medicine (D. Wong, Janssen, Fung), University of Toronto, Toronto Centre for Liver Disease, Toronto, Ont.; Department of Medicine (A. Wong), University of Saskatchewan; Regina General Hospital (Ukabam), Regina, Sask.; Bailey Health Clinic (Bailey), Edmonton, Alta.; Department of Medicine (Tsoi), McMaster University, St. Joseph's Healthcare, Hamilton, Ont.; Vancouver Infectious Diseases Centre (Conway), Vancouver, BC; Division of Infectious Diseases (Barrett), Dalhousie University, Halifax, NS; Faculty of Medicine (Michalak), Memorial University of Newfoundland, St. John's, Nfld.; Department of Internal Medicine (Minuk, Uhanova, Miles, Kaita), University of Manitoba; National Microbiology Laboratory (Osiowy), Public Health Agency of Canada, Winnipeg, Man.

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http://dx.doi.org/10.9778/cmajo.20190103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6813030PMC
October 2019

Reply.

Hepatology 2020 Feb 28;71(2):769. Epub 2020 Jan 28.

Toronto Centre for Liver Disease, University Health Network, Toronto, ON, Canada.

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http://dx.doi.org/10.1002/hep.30980DOI Listing
February 2020

CAPS1 Suppresses Tumorigenesis in Cholangiocarcinoma.

Dig Dis Sci 2020 04 27;65(4):1053-1063. Epub 2019 Sep 27.

Department of Gastroenterology and Hepatology, Zhongshan Hospital, Fudan University, Shanghai, People's Republic of China.

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http://dx.doi.org/10.1007/s10620-019-05843-9DOI Listing
April 2020

Hepatitis C Core-Antigen Testing from Dried Blood Spots.

Viruses 2019 09 6;11(9). Epub 2019 Sep 6.

Toronto Centre for Liver Disease, Toronto General Hospital, University Health Network, University of Toronto, Toronto, ON M5G 2C4, Canada.

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http://dx.doi.org/10.3390/v11090830DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6784259PMC
September 2019

Limited sustained response after stopping nucleos(t)ide analogues in patients with chronic hepatitis B: results from a randomised controlled trial (Toronto STOP study).

Gut 2019 12 28;68(12):2206-2213. Epub 2019 Aug 28.

Toronto Centre for Liver Disease, Toronto General Hospital, University Health Network, Toronto, Ontario, Canada

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http://dx.doi.org/10.1136/gutjnl-2019-318981DOI Listing
December 2019

Idiopathic Noncirrhotic Portal Hypertension.

Gastroenterol Hepatol (N Y) 2019 Jul;15(7):393-395

Francis Family Chair in Liver Research Director, Toronto Centre for Liver Disease Professor of Medicine, University of Toronto Toronto General Hospital Toronto, Ontario, Canada.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6676350PMC
July 2019

Nonalcoholic Steatohepatitis Is Associated With Liver-Related Outcomes and All-Cause Mortality in Chronic Hepatitis B.

Hepatology 2020 Feb 17;71(2):539-548. Epub 2019 Oct 17.

Toronto Centre for Liver Disease, University Health Network, Toronto, ON, Canada.

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http://dx.doi.org/10.1002/hep.30857DOI Listing
February 2020

Reply.

Clin Gastroenterol Hepatol 2020 01 17;18(1):267-268. Epub 2019 Jun 17.

Division of Gastroenterology, Toronto General Hospital, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.1016/j.cgh.2019.06.019DOI Listing
January 2020

Prevalence and Impact of Hepatitis E Virus Infection Among Persons With Chronic Hepatitis B Living in the US and Canada.

Open Forum Infect Dis 2019 May 9;6(5):ofz175. Epub 2019 Apr 9.

UNC Liver Center, Division of Gastroenterology and Hepatology, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.

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http://dx.doi.org/10.1093/ofid/ofz175DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6527087PMC
May 2019

Elevated serum levels of soluble CD14 in HBeAg-positive chronic HBV patients upon Peginterferon treatment are associated with treatment response.

J Viral Hepat 2019 09 3;26(9):1076-1085. Epub 2019 Jun 3.

Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1111/jvh.13127DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6852593PMC
September 2019

Optimisation of the use of APRI and FIB-4 to rule out cirrhosis in patients with chronic hepatitis B: results from the SONIC-B study.

Lancet Gastroenterol Hepatol 2019 07 9;4(7):538-544. Epub 2019 Apr 9.

Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Rotterdam, Netherlands; Toronto Centre for Liver Disease, University Health Network, Toronto, Canada. Electronic address:

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http://dx.doi.org/10.1016/S2468-1253(19)30087-1DOI Listing
July 2019

Prevalence and predictors of complementary and alternative medicine modalities in patients with chronic hepatitis B.

Liver Int 2019 08 22;39(8):1418-1427. Epub 2019 Apr 22.

Toronto Centre for Liver Disease, Toronto General Hospital, University Health Network, Toronto, Canada.

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https://onlinelibrary.wiley.com/doi/abs/10.1111/liv.14105
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http://dx.doi.org/10.1111/liv.14105DOI Listing
August 2019

Reply.

Clin Gastroenterol Hepatol 2019 04;17(5):1001-1002

Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands; Toronto Centre of Liver Disease, University Health Network, Toronto General Hospital, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.cgh.2018.10.005DOI Listing
April 2019

Role of Autophagy in Chronic Liver Inflammation and Fibrosis.

Curr Protein Pept Sci 2019 ;20(8):817-822

Department of Gastroenterology and Hepatology, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.

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http://dx.doi.org/10.2174/1389203720666190305165203DOI Listing
September 2019

Editorial: identifying candidates for pegylated interferon add-on to entecavir therapy in patients with HBeAg-positive chronic hepatitis B - authors' reply.

Aliment Pharmacol Ther 2019 03;49(5):610-611

Toronto Centre for Liver Disease, Toronto General Hospital, University Health Network, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1111/apt.15155DOI Listing
March 2019

HBV Genotype-Specific Levels of Hepatitis B Surface Antigen Improve HBV Phenotype Definition.

Clin Gastroenterol Hepatol 2020 01 7;18(1):259-261. Epub 2019 Jan 7.

Toronto Centre for Liver Disease, Toronto General Hospital, Toronto, Canada; Department of Gastroenterology and Hepatology, Erasmus University Medical Centre, Rotterdam, the Netherlands. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15423565193001
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http://dx.doi.org/10.1016/j.cgh.2018.12.039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6612468PMC
January 2020

Effects of Age and Sex of Response to Ursodeoxycholic Acid and Transplant-free Survival in Patients With Primary Biliary Cholangitis.

Clin Gastroenterol Hepatol 2019 09 4;17(10):2076-2084.e2. Epub 2019 Jan 4.

Department of Gastroenterology and Hepatology, Erasmus University Medical Centre, Rotterdam, The Netherlands; Toronto Centre for Liver Disease, Toronto General Hospital, University Health Network, Toronto, Ontario, Canada; Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15423565193000
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http://dx.doi.org/10.1016/j.cgh.2018.12.028DOI Listing
September 2019

Long-term Effects of Treatment for Chronic HBV Infection on Patient-Reported Outcomes.

Clin Gastroenterol Hepatol 2019 07 27;17(8):1641-1642.e1. Epub 2018 Sep 27.

Center for Outcomes Research in Liver Disease, Washington, DC.

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http://dx.doi.org/10.1016/j.cgh.2018.09.041DOI Listing
July 2019

microRNA-19a-3p promotes tumor metastasis and chemoresistance through the PTEN/Akt pathway in hepatocellular carcinoma.

Biomed Pharmacother 2018 Sep 21;105:1147-1154. Epub 2018 Jun 21.

Department of Gastroenterology, Zhongshan Hospital of Fudan University, Shanghai, China. Electronic address:

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http://dx.doi.org/10.1016/j.biopha.2018.06.097DOI Listing
September 2018

Spermine oxidase is upregulated and promotes tumor growth in hepatocellular carcinoma.

Hepatol Res 2018 Nov 27;48(12):967-977. Epub 2018 Jul 27.

Department of Gastroenterology and Hepatology, Shanghai Institute of Liver Disease, Zhongshan Hospital, Fudan University, Shanghai, China.

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http://dx.doi.org/10.1111/hepr.13206DOI Listing
November 2018

Serum Level of Antibodies Against Hepatitis B Core Protein Is Associated With Clinical Relapse After Discontinuation of Nucleos(t)ide Analogue Therapy.

Clin Gastroenterol Hepatol 2019 01 11;17(1):182-191.e1. Epub 2018 Jun 11.

Department of Infectious Diseases, Guangdong Provincial Key Laboratory of Viral Hepatitis Research, Nanfang Hospital, Southern Medical University, Guangzhou, China. Electronic address:

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http://dx.doi.org/10.1016/j.cgh.2018.05.047DOI Listing
January 2019

Hepatitis B virus infection.

Nat Rev Dis Primers 2018 06 7;4:18035. Epub 2018 Jun 7.

Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong.

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http://dx.doi.org/10.1038/nrdp.2018.35DOI Listing
June 2018

Publicly Funded Oral Chronic Hepatitis B Treatment Patterns in Ontario over 16 Years: An Ecologic Study.

J Manag Care Spec Pharm 2018 May;24(5):464-468

1 Li Ka Shing Knowledge Institute, St. Michael's Hospital; Institute for Clinical Evaluative Sciences; and Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.18553/jmcp.2018.24.5.464DOI Listing
May 2018

Effects of Treatment of Chronic Hepatitis B Virus Infection on Patient-Reported Outcomes.

Clin Gastroenterol Hepatol 2018 10 2;16(10):1641-1649.e6. Epub 2018 Mar 2.

Center for Outcomes Research in Liver Disease, Washington, District of Columbia.

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http://dx.doi.org/10.1016/j.cgh.2018.02.037DOI Listing
October 2018

Peroxiredoxin 1, restraining cell migration and invasion, is involved in hepatocellular carcinoma recurrence.

J Dig Dis 2018 Mar;19(3):155-169

Department of Gastroenterology, Zhongshan Hospital, Fudan University, Shanghai, China.

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http://dx.doi.org/10.1111/1751-2980.12580DOI Listing
March 2018

Hepatitis B virus infection.

Best Pract Res Clin Gastroenterol 2017 06 9;31(3):237. Epub 2017 Jun 9.

IFI-Institute for Interdisciplinary Medicine, University of Hamburg, Hamburg, Germany.

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http://dx.doi.org/10.1016/j.bpg.2017.05.009DOI Listing
June 2017

How viral genetic variants and genotypes influence disease and treatment outcome of chronic hepatitis B. Time for an individualised approach?

J Hepatol 2017 12 21;67(6):1281-1297. Epub 2017 Jul 21.

Toronto Centre for Liver Diseases, Toronto General Hospital, 200 Elizabeth Street, Toronto, Ontario M5G 2C4, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jhep.2017.07.011DOI Listing
December 2017

Unique intrahepatic transcriptomics profiles discriminate the clinical phases of a chronic HBV infection.

PLoS One 2017 29;12(6):e0179920. Epub 2017 Jun 29.

Department of Gastroenterology and Hepatology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0179920PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5491066PMC
September 2017

Coffee and herbal tea consumption is associated with lower liver stiffness in the general population: The Rotterdam study.

J Hepatol 2017 08 1;67(2):339-348. Epub 2017 Jun 1.

Department of Gastroenterology and Hepatology, Erasmus MC University Medical Centre, Rotterdam, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.jhep.2017.03.013DOI Listing
August 2017

Hepatitis C treatment and liver cancer recurrence: cause for concern?

Lancet Gastroenterol Hepatol 2017 02 12;2(2):78-80. Epub 2017 Jan 12.

Department of Gastroenterology and Hepatology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands.

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http://dx.doi.org/10.1016/S2468-1253(16)30204-7DOI Listing
February 2017

Gamma-glutamyltransferase levels, prediabetes and type 2 diabetes: a Mendelian randomization study.

Int J Epidemiol 2017 10;46(5):1400-1409

Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1093/ije/dyx006DOI Listing
October 2017

Off-Treatment Hepatitis B Virus (HBV) DNA Levels and the Prediction of Relapse After Discontinuation of Nucleos(t)ide Analogue Therapy in Patients With Chronic Hepatitis B: A Prospective Stop Study.

J Infect Dis 2017 02;215(4):581-589

Department of Infectious Diseases, Guangdong Provincial Key Laboratory of Viral Hepatitis Research, Nanfang Hospital, Southern Medical University, Guangzhou, China.

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http://dx.doi.org/10.1093/infdis/jix025DOI Listing
February 2017

Efficacy and Safety of Direct Acting Antivirals for the Treatment of Mixed Cryoglobulinemia.

Am J Gastroenterol 2017 Aug 14;112(8):1298-1308. Epub 2017 Mar 14.

Toronto Centre for Liver Disease, University Health Network, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1038/ajg.2017.49DOI Listing
August 2017

Ethics and hepatitis B cure research.

Gut 2017 03 14;66(3):389-392. Epub 2016 Nov 14.

The Royal Melbourne Hospital at the Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, Australia.

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http://gut.bmj.com/lookup/doi/10.1136/gutjnl-2016-313009
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http://dx.doi.org/10.1136/gutjnl-2016-313009DOI Listing
March 2017