Harry L A Janssen

Harry L A Janssen

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Harry L A Janssen

Publications by authors named "Harry L A Janssen"

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Elevated serum levels of soluble CD14 in HBeAg-positive chronic HBV patients upon Peginterferon treatment are associated with treatment response.

J Viral Hepat 2019 May 15. Epub 2019 May 15.

Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center Rotterdam, The Netherlands.

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http://dx.doi.org/10.1111/jvh.13127DOI Listing
May 2019

Reply.

Clin Gastroenterol Hepatol 2019 Apr;17(5):1001-1002

Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands; Toronto Centre of Liver Disease, University Health Network, Toronto General Hospital, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.cgh.2018.10.005DOI Listing
April 2019

Optimisation of the use of APRI and FIB-4 to rule out cirrhosis in patients with chronic hepatitis B: results from the SONIC-B study.

Lancet Gastroenterol Hepatol 2019 Apr 8. Epub 2019 Apr 8.

Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Rotterdam, Netherlands; Toronto Centre for Liver Disease, University Health Network, Toronto, Canada. Electronic address:

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http://dx.doi.org/10.1016/S2468-1253(19)30087-1DOI Listing
April 2019

Editorial: identifying candidates for pegylated interferon add-on to entecavir therapy in patients with HBeAg-positive chronic hepatitis B - authors' reply.

Aliment Pharmacol Ther 2019 Mar;49(5):610-611

Toronto Centre for Liver Disease, Toronto General Hospital, University Health Network, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1111/apt.15155DOI Listing
March 2019

Role of Autophagy in Chronic Liver Inflammation and Fibrosis.

Curr Protein Pept Sci 2019 Mar 5. Epub 2019 Mar 5.

Department of Gastroenterology and Hepatology, Zhongshan Hospital, Fudan University, Shanghai, 200032. China.

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http://dx.doi.org/10.2174/1389203720666190305165203DOI Listing
March 2019

Serum Level of Antibodies Against Hepatitis B Core Protein Is Associated With Clinical Relapse After Discontinuation of Nucleos(t)ide Analogue Therapy.

Clin Gastroenterol Hepatol 2019 Jan 11;17(1):182-191.e1. Epub 2018 Jun 11.

Department of Infectious Diseases, Guangdong Provincial Key Laboratory of Viral Hepatitis Research, Nanfang Hospital, Southern Medical University, Guangzhou, China. Electronic address:

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http://dx.doi.org/10.1016/j.cgh.2018.05.047DOI Listing
January 2019

HBV Genotype-Specific Levels of Hepatitis B Surface Antigen Improve HBV Phenotype Definition.

Clin Gastroenterol Hepatol 2019 Jan 7. Epub 2019 Jan 7.

Toronto Centre for Liver Disease, Toronto General Hospital, Toronto, Canada; Erasmus University Medical Centre, Rotterdam, the Netherlands. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15423565193001
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http://dx.doi.org/10.1016/j.cgh.2018.12.039DOI Listing
January 2019

Spermine oxidase is upregulated and promotes tumor growth in hepatocellular carcinoma.

Hepatol Res 2018 Nov 27;48(12):967-977. Epub 2018 Jul 27.

Department of Gastroenterology and Hepatology, Shanghai Institute of Liver Disease, Zhongshan Hospital, Fudan University, Shanghai, China.

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http://dx.doi.org/10.1111/hepr.13206DOI Listing
November 2018

Effects of Treatment of Chronic Hepatitis B Virus Infection on Patient-Reported Outcomes.

Clin Gastroenterol Hepatol 2018 Oct 2;16(10):1641-1649.e6. Epub 2018 Mar 2.

Center for Outcomes Research in Liver Disease, Washington, District of Columbia.

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http://dx.doi.org/10.1016/j.cgh.2018.02.037DOI Listing
October 2018

microRNA-19a-3p promotes tumor metastasis and chemoresistance through the PTEN/Akt pathway in hepatocellular carcinoma.

Biomed Pharmacother 2018 Sep 21;105:1147-1154. Epub 2018 Jun 21.

Department of Gastroenterology, Zhongshan Hospital of Fudan University, Shanghai, China. Electronic address:

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http://dx.doi.org/10.1016/j.biopha.2018.06.097DOI Listing
September 2018

Long-Term Effects of Treatment for Chronic HBV Infection on Patient-Reported Outcomes.

Clin Gastroenterol Hepatol 2018 Sep 27. Epub 2018 Sep 27.

Center for Outcomes Research in Liver Disease, Washington, DC.

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http://dx.doi.org/10.1016/j.cgh.2018.09.041DOI Listing
September 2018

Hepatitis B virus infection.

Nat Rev Dis Primers 2018 Jun 7;4:18035. Epub 2018 Jun 7.

Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong.

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http://dx.doi.org/10.1038/nrdp.2018.35DOI Listing
June 2018

Publicly Funded Oral Chronic Hepatitis B Treatment Patterns in Ontario over 16 Years: An Ecologic Study.

J Manag Care Spec Pharm 2018 May;24(5):464-468

1 Li Ka Shing Knowledge Institute, St. Michael's Hospital; Institute for Clinical Evaluative Sciences; and Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.18553/jmcp.2018.24.5.464DOI Listing
May 2018

Peroxiredoxin 1, restraining cell migration and invasion, is involved in hepatocellular carcinoma recurrence.

J Dig Dis 2018 Mar;19(3):155-169

Department of Gastroenterology, Zhongshan Hospital, Fudan University, Shanghai, China.

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http://dx.doi.org/10.1111/1751-2980.12580DOI Listing
March 2018

How viral genetic variants and genotypes influence disease and treatment outcome of chronic hepatitis B. Time for an individualised approach?

J Hepatol 2017 12 21;67(6):1281-1297. Epub 2017 Jul 21.

Toronto Centre for Liver Diseases, Toronto General Hospital, 200 Elizabeth Street, Toronto, Ontario M5G 2C4, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jhep.2017.07.011DOI Listing
December 2017

Gamma-glutamyltransferase levels, prediabetes and type 2 diabetes: a Mendelian randomization study.

Int J Epidemiol 2017 10;46(5):1400-1409

Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1093/ije/dyx006DOI Listing
October 2017

Unique intrahepatic transcriptomics profiles discriminate the clinical phases of a chronic HBV infection.

PLoS One 2017 29;12(6):e0179920. Epub 2017 Jun 29.

Department of Gastroenterology and Hepatology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0179920PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5491066PMC
September 2017

The Effect of Chronic Hepatitis B Virus Infection on BDCA3+ Dendritic Cell Frequency and Function.

PLoS One 2016 16;11(8):e0161235. Epub 2016 Aug 16.

Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, The Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0161235PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4987041PMC
August 2017

Efficacy and Safety of Direct Acting Antivirals for the Treatment of Mixed Cryoglobulinemia.

Am J Gastroenterol 2017 Aug 14;112(8):1298-1308. Epub 2017 Mar 14.

Toronto Centre for Liver Disease, University Health Network, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1038/ajg.2017.49DOI Listing
August 2017

Coffee and herbal tea consumption is associated with lower liver stiffness in the general population: The Rotterdam study.

J Hepatol 2017 08 1;67(2):339-348. Epub 2017 Jun 1.

Department of Gastroenterology and Hepatology, Erasmus MC University Medical Centre, Rotterdam, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.jhep.2017.03.013DOI Listing
August 2017

Hepatitis B virus infection.

Best Pract Res Clin Gastroenterol 2017 06 9;31(3):237. Epub 2017 Jun 9.

IFI-Institute for Interdisciplinary Medicine, University of Hamburg, Hamburg, Germany.

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http://dx.doi.org/10.1016/j.bpg.2017.05.009DOI Listing
June 2017

Ethics and hepatitis B cure research.

Gut 2017 03 14;66(3):389-392. Epub 2016 Nov 14.

The Royal Melbourne Hospital at the Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, Australia.

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http://gut.bmj.com/lookup/doi/10.1136/gutjnl-2016-313009
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http://dx.doi.org/10.1136/gutjnl-2016-313009DOI Listing
March 2017

The role of quantitative hepatitis B surface antigen revisited.

J Hepatol 2017 02 27;66(2):398-411. Epub 2016 Aug 27.

Department of Medicine and Therapeutics, Institute of Digestive Disease and State Key Laboratory of Digestive Disease, The Chinese University of Hong Kong, Hong Kong. Electronic address:

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http://dx.doi.org/10.1016/j.jhep.2016.08.009DOI Listing
February 2017

Reply.

Hepatology 2017 02 6;65(2):749-750. Epub 2016 Oct 6.

Francis Family Chair in Liver Research, Toronto Centre for Liver Disease Professor of Medicine, University of Toronto University Health Network, Toronto General Hospital.

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http://dx.doi.org/10.1002/hep.28789DOI Listing
February 2017

Off-Treatment Hepatitis B Virus (HBV) DNA Levels and the Prediction of Relapse After Discontinuation of Nucleos(t)ide Analogue Therapy in Patients With Chronic Hepatitis B: A Prospective Stop Study.

J Infect Dis 2017 02;215(4):581-589

Department of Infectious Diseases, Guangdong Provincial Key Laboratory of Viral Hepatitis Research, Nanfang Hospital, Southern Medical University, Guangzhou, China.

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http://dx.doi.org/10.1093/infdis/jix025DOI Listing
February 2017

Hepatitis C treatment and liver cancer recurrence: cause for concern?

Lancet Gastroenterol Hepatol 2017 02 12;2(2):78-80. Epub 2017 Jan 12.

Department of Gastroenterology and Hepatology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands.

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http://dx.doi.org/10.1016/S2468-1253(16)30204-7DOI Listing
February 2017

Multiple biopsy passes and the risk of complications of percutaneous liver biopsy.

Eur J Gastroenterol Hepatol 2017 Jan;29(1):36-41

aDepartment of Gastroenterology and Hepatology, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands bDepartment of Gastroenterology and Hepatology, AZ Nikolaas, Sint-Niklaas, Belgium cToronto Centre for Liver Disease, Toronto General Hospital, University of Toronto, Toronto, Ontario, Canada.

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http://pdfs.journals.lww.com/eurojgh/2017/01000/Multiple_bio
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http://dx.doi.org/10.1097/MEG.0000000000000731DOI Listing
January 2017

Safety and Effectiveness of Direct-Acting Antiviral Agents for Treatment of Patients With Chronic Hepatitis C Virus Infection and Cirrhosis.

Clin Gastroenterol Hepatol 2016 12 9;14(12):1821-1830.e6. Epub 2016 Jul 9.

Toronto Centre for Liver Disease, Toronto Western and General Hospital, University Health Network, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.1016/j.cgh.2016.07.001DOI Listing
December 2016

Repeated Measurements of Hepatitis B Surface Antigen Identify Carriers of Inactive HBV During Long-term Follow-up.

Clin Gastroenterol Hepatol 2016 10 10;14(10):1481-1489.e5. Epub 2016 Feb 10.

Department of Gastroenterology and Hepatology, Erasmus MC, Rotterdam, the Netherlands; Department of Public Health, Erasmus MC, Rotterdam, the Netherlands.

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http://dx.doi.org/10.1016/j.cgh.2016.01.019DOI Listing
October 2016

Entecavir plus tenofovir combination therapy for chronic hepatitis B in patients with previous nucleos(t)ide treatment failure.

Hepatol Int 2016 Sep 20;10(5):779-88. Epub 2016 May 20.

Department of Gastroenterology and Hepatology, Erasmus Medical Center, University Medical Center Rotterdam, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1007/s12072-016-9737-2DOI Listing
September 2016

The applicability of hepatocellular carcinoma risk prediction scores in a North American patient population with chronic hepatitis B infection.

Gut 2016 08 30;65(8):1347-58. Epub 2015 Apr 30.

Toronto Centre for Liver Disease, University Health Network, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1136/gutjnl-2014-309099DOI Listing
August 2016

Thyroid Function and the Risk of Nonalcoholic Fatty Liver Disease: The Rotterdam Study.

J Clin Endocrinol Metab 2016 08 7;101(8):3204-11. Epub 2016 Jun 7.

Department of Internal Medicine (A.B., L.C., R.P.P.), Erasmus University Medical Center, 3015 GE, Rotterdam, The Netherlands; Rotterdam Thyroid Center (A.B., L.C., R.P.P.), Erasmus University Medical Center, 3015 GE, Rotterdam, The Netherlands; Department of Epidemiology (A.B., L.C., E.P.C.P., A.H., A.D., O.H.F., S.D.M., R.P.P.), Erasmus University Medical Center, 3015 GE, Rotterdam, The Netherlands; Department of Gastroenterology and Hepatology (E.P.C.P., H.L.A.J., S.D.M.), Erasmus University Medical Center, 3015 GE, Rotterdam, The Netherlands; and Toronto Centre for Liver Disease (H.L.A.J.), Toronto Western and General Hospital, University Health Network, Toronto, Ontario, M5G 2C4 Canada.

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https://academic.oup.com/jcem/article-lookup/doi/10.1210/jc.
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http://dx.doi.org/10.1210/jc.2016-1300DOI Listing
August 2016

GI ischemia in patients with portal vein thrombosis: a prospective cohort study.

Gastrointest Endosc 2016 Mar 29;83(3):627-36. Epub 2015 Aug 29.

Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.gie.2015.07.013DOI Listing
March 2016

Stratification of hepatocellular carcinoma risk in primary biliary cirrhosis: a multicentre international study.

Gut 2016 Feb 7;65(2):321-9. Epub 2015 Jan 7.

National Institute for Health Research (NIHR) Birmingham Liver Biomedical Research Unit (BRU) and Centre for Liver Research, University of Birmingham, Birmingham, UK Liver Unit, Queen Elizabeth Hospital, Birmingham, UK.

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http://dx.doi.org/10.1136/gutjnl-2014-308351DOI Listing
February 2016

Increased Prevalence of Advanced Liver Fibrosis in Patients with Psoriasis: A Cross-sectional Analysis from the Rotterdam Study.

Acta Derm Venereol 2016 Feb;96(2):213-7

Department of Dermatology, Erasmus MC, University Medical Center Rotterdam, Postbus 2040, 3000 CA Rotterdam, The Netherlands.

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http://www.medicaljournals.se/acta/content/?doi=10.2340/0001
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http://dx.doi.org/10.2340/00015555-2161DOI Listing
February 2016

New therapeutic agents for chronic hepatitis B.

Lancet Infect Dis 2016 Feb 13;16(2):e10-21. Epub 2016 Jan 13.

Toronto Centre for Liver Diseases, Toronto Western Hospital, University Health Network, Toronto, ON, Canada; Department of Gastroenterology and Hepatology, Erasmus Medical Center University Hospital, Rotterdam, Netherlands. Electronic address:

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http://dx.doi.org/10.1016/S1473-3099(15)00436-3DOI Listing
February 2016

Immunological Analysis During Interferon-Free Therapy for Chronic Hepatitis C Virus Infection Reveals Modulation of the Natural Killer Cell Compartment.

J Infect Dis 2016 Jan 28;213(2):216-23. Epub 2015 Jul 28.

Department of Gastroenterology and Hepatology, Erasmus MC, University Medical Center Rotterdam, The Netherlands.

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http://dx.doi.org/10.1093/infdis/jiv391DOI Listing
January 2016

Liver Contrast-Enhanced Ultrasound Improves Detection of Liver Metastases in Patients with Pancreatic or Periampullary Cancer.

Ultrasound Med Biol 2015 Dec 1;41(12):3063-9. Epub 2015 Oct 1.

Department of Surgery, Erasmus Medical Center, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.ultrasmedbio.2015.06.019DOI Listing
December 2015

A Treatment Algorithm for the Management of Chronic Hepatitis B Virus Infection in the United States: 2015 Update.

Clin Gastroenterol Hepatol 2015 Nov 15;13(12):2071-87.e16. Epub 2015 Jul 15.

Department of Medicine, Mount Sinai Beth Israel, Icahn School of Medicine at Mount Sinai, New York, New York.

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https://linkinghub.elsevier.com/retrieve/pii/S15423565150096
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http://dx.doi.org/10.1016/j.cgh.2015.07.007DOI Listing
November 2015

Longitudinal analysis of peripheral and intrahepatic NK cells in chronic HCV patients during antiviral therapy.

Antiviral Res 2015 Nov 9;123:86-92. Epub 2015 Sep 9.

Department of Gastroenterology and Hepatology, Erasmus MC - University Medical Center Rotterdam, The Netherlands. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01663542150021
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http://dx.doi.org/10.1016/j.antiviral.2015.09.006DOI Listing
November 2015

Can we use HCC risk scores to individualize surveillance in chronic hepatitis B infection?

J Hepatol 2015 Sep 27;63(3):722-32. Epub 2015 May 27.

Toronto Center for Liver Disease, Toronto Western and General Hospital, University Health Network, Toronto, Canada; Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Rotterdam, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.jhep.2015.05.019DOI Listing
September 2015

The Intrahepatic T Cell Compartment Does Not Normalize Years After Therapy-Induced Hepatitis C Virus Eradication.

J Infect Dis 2015 Aug 30;212(3):386-90. Epub 2015 Jan 30.

Department of Gastroenterology and Hepatology.

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http://dx.doi.org/10.1093/infdis/jiv059DOI Listing
August 2015

Immigration and viral hepatitis.

J Hepatol 2015 Aug 8;63(2):515-22. Epub 2015 May 8.

Toronto Centre for Liver Disease, University Health Network, University of Toronto, Toronto, Canada; Department of Gastroenterology and Hepatology, Erasmus MC University Medical Centre, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.jhep.2015.04.026DOI Listing
August 2015

An intrahepatic transcriptional signature of enhanced immune activity predicts response to peginterferon in chronic hepatitis B.

Liver Int 2015 Jul 21;35(7):1824-32. Epub 2015 Jan 21.

Department of Gastroenterology and Hepatology, Academic Medical Center (AMC), University of Amsterdam (UvA), Amsterdam, The Netherlands.

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http://dx.doi.org/10.1111/liv.12768DOI Listing
July 2015

Re-evaluation of hepatitis B virus clinical phases by systems biology identifies unappreciated roles for the innate immune response and B cells.

Hepatology 2015 Jul 27;62(1):87-100. Epub 2015 Apr 27.

Department of Gastroenterology and Hepatology, Erasmus University Medical Center, Rotterdam, The Netherlands.

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http://doi.wiley.com/10.1002/hep.27805
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http://dx.doi.org/10.1002/hep.27805DOI Listing
July 2015

BDCA3 expression is associated with high IFN-λ production by CD34(+)-derived dendritic cells generated in the presence of GM-CSF, IL-4, and/or TGF-β.

Eur J Immunol 2015 May 14;45(5):1471-81. Epub 2015 Feb 14.

Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, The Netherlands.

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http://doi.wiley.com/10.1002/eji.201444802
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http://dx.doi.org/10.1002/eji.201444802DOI Listing
May 2015

Risk of hepatocellular carcinoma in chronic hepatitis B: assessment and modification with current antiviral therapy.

J Hepatol 2015 Apr 13;62(4):956-67. Epub 2015 Jan 13.

1st Division of Gastroenterology, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Università degli Studi di Milano, Milan, Italy.

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http://dx.doi.org/10.1016/j.jhep.2015.01.002DOI Listing
April 2015

How to achieve immune control in chronic hepatitis B?

Hepatol Int 2015 Jan 6;9(1):9-16. Epub 2014 Sep 6.

Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1007/s12072-014-9571-3DOI Listing
January 2015