Harry G Leitch

Harry G Leitch

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Harry G Leitch

Harry G Leitch

Publications by authors named "Harry G Leitch"

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Defined conditions for propagation and manipulation of mouse embryonic stem cells.

Development 2019 03 26;146(6). Epub 2019 Mar 26.

Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Gleeson Building, Tennis Court Road, Cambridge CB2 1QR, UK

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http://dx.doi.org/10.1242/dev.173146DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451320PMC
March 2019

SLIC-CAGE: high-resolution transcription start site mapping using nanogram-levels of total RNA.

Genome Res 2018 12 7;28(12):1943-1956. Epub 2018 Nov 7.

Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London W12 0NN, United Kingdom.

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http://genome.cshlp.org/lookup/doi/10.1101/gr.235937.118
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http://dx.doi.org/10.1101/gr.235937.118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6280763PMC
December 2018

Publisher Correction: Eggs sense high-fat diet.

Nat Genet 2018 08;50(8):1196

MRC London Institute of Medical Sciences (LMS), London, UK.

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http://dx.doi.org/10.1038/s41588-018-0137-5DOI Listing
August 2018

Eggs sense high-fat diet.

Nat Genet 2018 03;50(3):318-319

MRC London Institute of Medical Sciences (LMS), London, UK.

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http://dx.doi.org/10.1038/s41588-018-0068-1DOI Listing
March 2018

Esrrb Complementation Rescues Development of Nanog-Null Germ Cells.

Cell Rep 2018 01;22(2):332-339

MRC Centre for Regenerative Medicine, Institute for Stem Cell Research, School of Biological Sciences, University of Edinburgh, 5 Little France Drive, Edinburgh EH16 4UU, Scotland. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.12.060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5775501PMC
January 2018

DNA (De)Methylation: The Passive Route to Naïvety?

Trends Genet 2016 10 17;32(10):592-595. Epub 2016 Aug 17.

MRC Clinical Sciences Centre, Du Cane Road, London W12 0NN, UK; Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, Du Cane Road, London W12 0NN, UK. Electronic address:

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http://dx.doi.org/10.1016/j.tig.2016.08.005DOI Listing
October 2016

Hallmarks of pluripotency.

Nature 2015 Sep;525(7570):469-78

Stem Cell Transplantation Program, Division of Pediatric Hematology Oncology, Children's Hospital Boston, and Dana-Farber Cancer Institute; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1038/nature15515DOI Listing
September 2015

A Unique Gene Regulatory Network Resets the Human Germline Epigenome for Development.

Cell 2015 Jun;161(6):1453-67

Wellcome Trust Cancer Research UK Gurdon Institute, Tennis Court Road, University of Cambridge, Cambridge CB2 1QN, UK; Department of Physiology, Development and Neuroscience, Downing Street, University of Cambridge, Cambridge CB2 3EG, UK; Wellcome Trust-Medical Research Council Stem Cell Institute, Tennis Court Road, University of Cambridge, Cambridge CB2 3EG, UK. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2015.04.053DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4459712PMC
June 2015

Rebuilding pluripotency from primordial germ cells.

Stem Cell Reports 2013 4;1(1):66-78. Epub 2013 Jun 4.

Wellcome Trust-Medical Research Council Stem Cell Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK ; Wellcome Trust/Cancer Research UK Gurdon Institute of Cancer and Developmental Biology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK.

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http://dx.doi.org/10.1016/j.stemcr.2013.03.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3757743PMC
May 2015

Synergistic mechanisms of DNA demethylation during transition to ground-state pluripotency.

Stem Cell Reports 2013 17;1(6):518-31. Epub 2013 Dec 17.

Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge, Cambridge CB2 1QN, UK ; Wellcome Trust/MRC Stem Cell Institute, University of Cambridge, Cambridge CB2 1QR, UK ; Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge CB2 3EG, UK.

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http://dx.doi.org/10.1016/j.stemcr.2013.11.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871394PMC
May 2015

Primordial germ-cell development and epigenetic reprogramming in mammals.

Curr Top Dev Biol 2013 ;104:149-87

Wellcome Trust/Cancer Research UK Gurdon Institute of Cancer and Developmental Biology, University of Cambridge, Cambridge, United Kingdom.

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http://dx.doi.org/10.1016/B978-0-12-416027-9.00005-XDOI Listing
March 2014

On the fate of primordial germ cells injected into early mouse embryos.

Dev Biol 2014 Jan 20;385(2):155-9. Epub 2013 Nov 20.

Department of Genetics and Development, Columbia University Medical Center, New York, NY, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ydbio.2013.11.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3928994PMC
January 2014

Prdm14 promotes germline fate and naive pluripotency by repressing FGF signalling and DNA methylation.

EMBO Rep 2013 Jul 14;14(7):629-37. Epub 2013 May 14.

Wellcome Trust/Cancer Research UK Gurdon Institute, Department of Physiology, Development and Neuroscience, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK.

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http://dx.doi.org/10.1038/embor.2013.67DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3701237PMC
July 2013

The impact of culture on epigenetic properties of pluripotent stem cells and pre-implantation embryos.

Biochem Soc Trans 2013 Jun;41(3):711-9

Medical Research Council Clinical Sciences Centre, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, U.K.

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http://dx.doi.org/10.1042/BST20130049DOI Listing
June 2013

The mammalian germline as a pluripotency cycle.

Development 2013 Jun;140(12):2495-501

Wellcome Trust-Medical Research Council Stem Cell Institute, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QR, UK.

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http://dev.biologists.org/cgi/doi/10.1242/dev.091603
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http://dx.doi.org/10.1242/dev.091603DOI Listing
June 2013

Naive pluripotency is associated with global DNA hypomethylation.

Nat Struct Mol Biol 2013 Mar 17;20(3):311-6. Epub 2013 Feb 17.

Wellcome Trust/Medical Research Council Stem Cell Institute, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.1038/nsmb.2510DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3591483PMC
March 2013

The germ cell determinant Blimp1 is not required for derivation of pluripotent stem cells.

Cell Stem Cell 2012 Jul;11(1):110-7

Wellcome Trust/Cancer Research UK Gurdon Institute of Cancer and Developmental Biology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QN, UK.

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http://dx.doi.org/10.1016/j.stem.2012.02.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3391686PMC
July 2012

Culture parameters for stable expansion, genetic modification and germline transmission of rat pluripotent stem cells.

Biol Open 2012 Jan 1;1(1):58-65. Epub 2011 Nov 1.

Wellcome Trust Centre for Stem Cell Research, University of Cambridge , Tennis Court Road, Cambridge CB2 1QN , UK ; Department of Biochemistry, University of Cambridge , Tennis Court Road, Cambridge CB2 1QN , UK.

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http://dx.doi.org/10.1242/bio.2011029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3507162PMC
January 2012

Embryonic germ cells from mice and rats exhibit properties consistent with a generic pluripotent ground state.

Development 2010 Jul 2;137(14):2279-87. Epub 2010 Jun 2.

Wellcome Trust Cancer Research UK Gurdon Institute, The Henry Wellcome Building of Cancer and Developmental Biology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK.

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http://dx.doi.org/10.1242/dev.050427DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2889601PMC
July 2010

Hypogonadotropic hypogonadism in mice lacking a functional Kiss1 gene.

Proc Natl Acad Sci U S A 2007 Jun 11;104(25):10714-9. Epub 2007 Jun 11.

Reproductive Physiology Group, Department of Physiology, Development, and Neuroscience, University of Cambridge, Cambridge CB2 3EG, United Kingdom.

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http://dx.doi.org/10.1073/pnas.0704114104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1965578PMC
June 2007