Harry Dolstra

Harry Dolstra

UNVERIFIED PROFILE

Are you Harry Dolstra?   Register this Author

Register author
Harry Dolstra

Harry Dolstra

Publications by authors named "Harry Dolstra"

Are you Harry Dolstra?   Register this Author

74Publications

1453Reads

33Profile Views

Peptide-mediated delivery of therapeutic mRNA in ovarian cancer.

Eur J Pharm Biopharm 2019 Aug 16;141:180-190. Epub 2019 May 16.

Dept. of Biochemistry, Radboud Institute for Molecular Life Sciences (RIMLS), Radboud University Medical Center, Geert Grooteplein 28, 6525 GA Nijmegen, the Netherlands. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ejpb.2019.05.014DOI Listing
August 2019

Comprehensive Phenotyping of T Cells Using Flow Cytometry.

Cytometry A 2019 Jun 4;95(6):647-654. Epub 2019 Feb 4.

Department of Laboratory Medicine - Laboratory of Hematology, Radboud Institute of Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cyto.a.23724DOI Listing
June 2019

CXCR4, but not CXCR3, drives CD8 T-cell entry into and migration through the murine bone marrow.

Eur J Immunol 2019 Apr 15;49(4):576-589. Epub 2019 Feb 15.

Department of Hematopoiesis, Sanquin Research and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/eji.201747438DOI Listing
April 2019

Intraperitoneal infusion of ex vivo-cultured allogeneic NK cells in recurrent ovarian carcinoma patients (a phase I study).

Medicine (Baltimore) 2019 Feb;98(5):e14290

Department of Laboratory Medicine, Laboratory of Hematology, Radboud Institute of Molecular Life Sciences, Nijmegen, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MD.0000000000014290DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380776PMC
February 2019

Increased Coexpression of PD-1, TIGIT, and KLRG-1 on Tumor-Reactive CD8 T Cells During Relapse after Allogeneic Stem Cell Transplantation.

Biol Blood Marrow Transplant 2018 04 26;24(4):666-677. Epub 2017 Dec 26.

Department of Laboratory Medicine-Laboratory of Hematology, Radboud University Medical Center, Nijmegen, The Netherlands. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbmt.2017.11.027DOI Listing
April 2018

Immune checkpoint molecules in acute myeloid leukaemia: managing the double-edged sword.

Br J Haematol 2018 04 9;181(1):38-53. Epub 2018 Jan 9.

Department of Laboratory Medicine - Laboratory of Haematology, Radboud University Medical Centre, Nijmegen, the Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/bjh.15078DOI Listing
April 2018

Monocyte-Derived Dendritic Cells with Silenced PD-1 Ligands and Transpresenting Interleukin-15 Stimulate Strong Tumor-Reactive T-cell Expansion.

Cancer Immunol Res 2017 08 21;5(8):710-715. Epub 2017 Jun 21.

Laboratory of Hematology, Department of Laboratory Medicine, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, the Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/2326-6066.CIR-16-0336DOI Listing
August 2017

The magnitude of cytokine production by stimulated CD56 cells is associated with early stages of systemic sclerosis.

Clin Immunol 2016 Dec 9;173:76-80. Epub 2016 Sep 9.

Department of Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, The Netherlands; Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.clim.2016.09.004DOI Listing
December 2016

Addition of 10-Day Decitabine to Fludarabine/Total Body Irradiation Conditioning is Feasible and Induces Tumor-Associated Antigen-Specific T Cell Responses.

Biol Blood Marrow Transplant 2016 06 6;22(6):1000-1008. Epub 2016 Feb 6.

Department of Hematology, Radboudumc, Nijmegen, the Netherlands; Department of Laboratory Medicine, Laboratory of Hematology, Radboudumc, Radboud Institute for Molecular Life Sciences, Nijmegen, The Netherlands. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbmt.2016.02.003DOI Listing
June 2016

Immunotherapeutic approaches to treat multiple myeloma.

Hum Vaccin Immunother 2014 11;10(4):896-910. Epub 2013 Dec 11.

Department of Laboratory Medicine-Laboratory of Hematology Radboud; University Medical Center; Nijmegen, The Netherlands.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4896532PMC
http://dx.doi.org/10.4161/hv.27380DOI Listing
April 2016

The Aryl Hydrocarbon Receptor Antagonist StemRegenin1 Improves In Vitro Generation of Highly Functional Natural Killer Cells from CD34(+) Hematopoietic Stem and Progenitor Cells.

Stem Cells Dev 2015 Dec 28;24(24):2886-98. Epub 2015 Oct 28.

2 Department of Laboratory Medicine, Laboratory of Hematology, Radboud University Medical Center , Nijmegen, the Netherlands .

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/scd.2014.0597DOI Listing
December 2015

Noninvasive Imaging of Tumor PD-L1 Expression Using Radiolabeled Anti-PD-L1 Antibodies.

Cancer Res 2015 Jul 14;75(14):2928-36. Epub 2015 May 14.

Departments of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, the Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/0008-5472.CAN-14-3477DOI Listing
July 2015

Umbilical cord blood-derived cellular products for cancer immunotherapy.

Cytotherapy 2015 Jun 18;17(6):739-748. Epub 2015 Mar 18.

Department of Stem Cell Transplantation and Cellular Therapy, University of Texas, MD Anderson Cancer Center, Houston, Texas, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jcyt.2015.03.005DOI Listing
June 2015

siRNA silencing of PD-1 ligands on dendritic cell vaccines boosts the expansion of minor histocompatibility antigen-specific CD8(+) T cells in NOD/SCID/IL2Rg(null) mice.

Cancer Immunol Immunother 2015 May 28;64(5):645-54. Epub 2015 Feb 28.

Department of Laboratory Medicine, Laboratory of Hematology, Radboud University Medical Center, Geert Grooteplein 8, P.O. Box 9101, 6500 HB, Nijmegen, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00262-015-1668-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4412509PMC
May 2015

Efficient nontoxic delivery of PD-L1 and PD-L2 siRNA into dendritic cell vaccines using the cationic lipid SAINT-18.

J Immunother 2015 May;38(4):145-54

Departments of *Hematology †Laboratory Medicine-Laboratory of Hematology, Radboud University Medical Center, Nijmegen ‡Synvolux Therapeutics B.V., Groningen, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/CJI.0000000000000071DOI Listing
May 2015

Time to : Superior tumor-reactive T cells for adoptive immunotherapy.

Oncoimmunology 2015 May 3;4(5):e1003016. Epub 2015 Feb 3.

Department of Laboratory Medicine - Laboratory of Hematology; Radboud university medical center ; Nijmegen, The Netherlands.

View Article

Download full-text PDF

Source
http://www.tandfonline.com/doi/full/10.1080/2162402X.2014.10
Publisher Site
http://dx.doi.org/10.1080/2162402X.2014.1003016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4485741PMC
May 2015

Targeting the IL17 pathway for the prevention of graft-versus-host disease.

Biol Blood Marrow Transplant 2014 Jun 22;20(6):752-9. Epub 2014 Feb 22.

Department of Laboratory Medicine - Laboratory of Hematology, Radboud University Medical Center, Nijmegen, The Netherlands; Nijmegen Centre for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbmt.2014.02.007DOI Listing
June 2014

Ex vivo generation of interstitial and Langerhans cell-like dendritic cell subset-based vaccines for hematological malignancies.

J Immunother 2014 Jun;37(5):267-77

Laboratory of Hematology, Department of Laboratory Medicine, Radboud University Medical Centre and Nijmegen Centre for Molecular Life Sciences, Nijmegen, the Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/CJI.0000000000000035DOI Listing
June 2014

The aryl hydrocarbon receptor antagonist StemRegenin 1 promotes human plasmacytoid and myeloid dendritic cell development from CD34+ hematopoietic progenitor cells.

Stem Cells Dev 2014 May 24;23(9):955-67. Epub 2014 Jan 24.

1 Laboratory of Hematology, Department of Laboratory Medicine, Radboud university medical center , Nijmegen, The Netherlands .

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/scd.2013.0521DOI Listing
May 2014

Immunogenicity of dendritic cells pulsed with MAGE3, Survivin and B-cell maturation antigen mRNA for vaccination of multiple myeloma patients.

Cancer Immunol Immunother 2013 Aug 2;62(8):1381-92. Epub 2013 Jun 2.

Laboratory of Hematology, Department of Laboratory Medicine, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Geert Grooteplein 8, P.O. Box 9101, 6500 HB, Nijmegen, The Netherlands.

View Article

Download full-text PDF

Source
http://link.springer.com/content/pdf/10.1007/s00262-013-1438
Web Search
http://link.springer.com/10.1007/s00262-013-1438-2
Publisher Site
http://dx.doi.org/10.1007/s00262-013-1438-2DOI Listing
August 2013

Homing characteristics of donor T cells after experimental allogeneic bone marrow transplantation and posttransplantation therapy for multiple myeloma.

Biol Blood Marrow Transplant 2013 Mar 21;19(3):378-86. Epub 2012 Dec 21.

Department of Laboratory Medicine, Laboratory of Hematology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbmt.2012.12.014DOI Listing
March 2013

Improving dendritic cell vaccine immunogenicity by silencing PD-1 ligands using siRNA-lipid nanoparticles combined with antigen mRNA electroporation.

Cancer Immunol Immunother 2013 Feb 19;62(2):285-97. Epub 2012 Aug 19.

Department of Laboratory Medicine, Laboratory of Hematology, Radboud University, Nijmegen Medical Centre, Nijmegen Centre for Molecular Life Sciences, Geert Grooteplein 8, P.O. Box 9101, 6500 HB, Nijmegen, The Netherlands.

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s00262-012-1334-1
Publisher Site
http://dx.doi.org/10.1007/s00262-012-1334-1DOI Listing
February 2013

Ex vivo generated natural killer cells acquire typical natural killer receptors and display a cytotoxic gene expression profile similar to peripheral blood natural killer cells.

Stem Cells Dev 2012 Nov 17;21(16):2926-38. Epub 2012 Jul 17.

Department of Vascular Biology and Thrombosis Research, Center for Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/scd.2011.0659DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3475144PMC
November 2012

Defining early human NK cell developmental stages in primary and secondary lymphoid tissues.

PLoS One 2012 3;7(2):e30930. Epub 2012 Feb 3.

Department of Laboratory Medicine-Laboratory of Medical Immunology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0030930PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3272048PMC
September 2012

Coinhibitory molecules in hematologic malignancies: targets for therapeutic intervention.

Blood 2012 Jul 4;120(4):728-36. Epub 2012 May 4.

Laboratory of Hematology, Department of Laboratory Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2012-02-412510DOI Listing
July 2012

B and T lymphocyte attenuator mediates inhibition of tumor-reactive CD8+ T cells in patients after allogeneic stem cell transplantation.

J Immunol 2012 Jul 25;189(1):39-49. Epub 2012 May 25.

Laboratory of Hematology, Department of Laboratory Medicine, Radboud University Nijmegen Medical Centre, Nijmegen Centre for Molecular Life Sciences, 6525 GA Nijmegen, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4049/jimmunol.1102807DOI Listing
July 2012

Defining the critical hurdles in cancer immunotherapy.

Authors:
Bernard A Fox Dolores J Schendel Lisa H Butterfield Steinar Aamdal James P Allison Paolo Antonio Ascierto Michael B Atkins Jirina Bartunkova Lothar Bergmann Neil Berinstein Cristina C Bonorino Ernest Borden Jonathan L Bramson Cedrik M Britten Xuetao Cao William E Carson Alfred E Chang Dainius Characiejus A Raja Choudhury George Coukos Tanja de Gruijl Robert O Dillman Harry Dolstra Glenn Dranoff Lindy G Durrant James H Finke Jerome Galon Jared A Gollob Cécile Gouttefangeas Fabio Grizzi Michele Guida Leif Håkansson Kristen Hege Ronald B Herberman F Stephen Hodi Axel Hoos Christoph Huber Patrick Hwu Kohzoh Imai Elizabeth M Jaffee Sylvia Janetzki Carl H June Pawel Kalinski Howard L Kaufman Koji Kawakami Yutaka Kawakami Ulrich Keilholtz Samir N Khleif Rolf Kiessling Beatrix Kotlan Guido Kroemer Rejean Lapointe Hyam I Levitsky Michael T Lotze Cristina Maccalli Michele Maio Jens-Peter Marschner Michael J Mastrangelo Giuseppe Masucci Ignacio Melero Cornelius Melief William J Murphy Brad Nelson Andrea Nicolini Michael I Nishimura Kunle Odunsi Pamela S Ohashi Jill O'Donnell-Tormey Lloyd J Old Christian Ottensmeier Michael Papamichail Giorgio Parmiani Graham Pawelec Enrico Proietti Shukui Qin Robert Rees Antoni Ribas Ruggero Ridolfi Gerd Ritter Licia Rivoltini Pedro J Romero Mohamed L Salem Rik J Scheper Barbara Seliger Padmanee Sharma Hiroshi Shiku Harpreet Singh-Jasuja Wenru Song Per Thor Straten Hideaki Tahara Zhigang Tian Sjoerd H van Der Burg Paul von Hoegen Ena Wang Marij Jp Welters Hauke Winter Tara Withington Jedd D Wolchok Weihua Xiao Laurence Zitvogel Heinz Zwierzina Francesco M Marincola Thomas F Gajewski Jon M Wigginton Mary L Disis

J Transl Med 2011 Dec 14;9:214. Epub 2011 Dec 14.

Earle A, Chiles Research Institute, Robert W, Franz Research Center, Providence Cancer Center, Providence Portland Medical Center, Portland, OR, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/1479-5876-9-214DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3338100PMC
December 2011

Polymorphisms in CCR6 are associated with chronic graft-versus-host disease and invasive fungal disease in matched-related hematopoietic stem cell transplantation.

Biol Blood Marrow Transplant 2011 Oct 18;17(10):1443-9. Epub 2011 Jul 18.

Department of Laboratory Medicine, Hematology Laboratory, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbmt.2011.07.004DOI Listing
October 2011

siRNA silencing of PD-L1 and PD-L2 on dendritic cells augments expansion and function of minor histocompatibility antigen-specific CD8+ T cells.

Blood 2010 Nov 3;116(22):4501-11. Epub 2010 Aug 3.

Department of Laboratory Medicine-Laboratory of Hematology, Radboud University NijmegenMedical Center, Nijmegen Center for Molecular Life Sciences, Nijmegen, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2010-04-278739DOI Listing
November 2010

An alternatively spliced CXCL16 isoform expressed by dendritic cells is a secreted chemoattractant for CXCR6+ cells.

J Leukoc Biol 2010 Jun 24;87(6):1029-39. Epub 2010 Feb 24.

Laboratory Medicine, Laboratory of Hematology and Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1189/jlb.0709482
Publisher Site
http://dx.doi.org/10.1189/jlb.0709482DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3210559PMC
June 2010

Efficient activation of LRH-1-specific CD8+ T-cell responses from transplanted leukemia patients by stimulation with P2X5 mRNA-electroporated dendritic cells.

J Immunother 2009 Jul-Aug;32(6):539-51

Central Hematology Laboratory, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre (RUNMC), Nijmegen, The Netherlands.

View Article

Download full-text PDF

Source
https://insights.ovid.com/crossref?an=00002371-200907000-000
Publisher Site
http://dx.doi.org/10.1097/CJI.0b013e3181987c22DOI Listing
October 2009

Aberrant expression of the hematopoietic-restricted minor histocompatibility antigen LRH-1 on solid tumors results in efficient cytotoxic T cell-mediated lysis.

Cancer Immunol Immunother 2009 Mar 22;58(3):429-39. Epub 2008 Aug 22.

Central Hematology Laboratory, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s00262-008-0569-3
Publisher Site
http://dx.doi.org/10.1007/s00262-008-0569-3DOI Listing
March 2009

Myeloid leukemic progenitor cells can be specifically targeted by minor histocompatibility antigen LRH-1-reactive cytotoxic T cells.

Blood 2009 Mar 12;113(10):2312-23. Epub 2008 Dec 12.

Central Hematology Laboratory, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2008-04-153825DOI Listing
March 2009

Expression of P2X5 in lymphoid malignancies results in LRH-1-specific cytotoxic T-cell-mediated lysis.

Br J Haematol 2008 Jun 10;141(6):799-807. Epub 2008 Apr 10.

Central Haematology Laboratory, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/j.1365-2141.2008.07125.x
Publisher Site
http://dx.doi.org/10.1111/j.1365-2141.2008.07125.xDOI Listing
June 2008

Refinement of molecular approaches to improve the chance of identification of hematopoietic-restricted minor histocompatibility antigens.

J Immunol Methods 2008 Jan 26;329(1-2):125-37. Epub 2007 Oct 26.

Central Hematology Laboratory, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.

View Article

Download full-text PDF

Source
http://linkinghub.elsevier.com/retrieve/pii/S002217590700319
Publisher Site
http://dx.doi.org/10.1016/j.jim.2007.10.001DOI Listing
January 2008

Cellular adoptive immunotherapy after allogeneic stem cell transplantation.

Curr Opin Oncol 2005 Nov;17(6):617-21

Department of Hematology and Central Hematology Laboratory, Radboud University Nijmegen Medical Centre, The Netherlands.

View Article

Download full-text PDF

Source
November 2005

Generation of autologous cytotoxic and helper T-cell responses against the B-cell leukemia-associated antigen HB-1: relevance for precursor B-ALL-specific immunotherapy.

Blood 2003 Oct 3;102(8):2885-91. Epub 2003 Jul 3.

Central Hematology Laboratory and Department of Hematology, University Medical Center St Radboud, 6500 HB Nijmegen, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2002-11-3584DOI Listing
October 2003

Biodistribution and retention time of retrovirally labeled T lymphocytes in mice is strongly influenced by the culture period before infusion.

J Immunother 2002 Sep-Oct;25(5):385-95

Department of Hemotology, University Medical Center St. Radboud, Nijmegen, The Netherlands.

View Article

Download full-text PDF

Source
March 2003

Generation of autologous cytotoxic and helper T-cell responses against the B-cell leukemia-associated antigen HB-1: relevance for precursor B-ALL-specific immunotherapy.

Blood 2003 Oct 3;102(8):2885-91. Epub 2003 Jul 3.

Central Hematology Laboratory and Department of Hematology, University Medical Center St Radboud, 6500 HB Nijmegen, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2002-11-3584DOI Listing
October 2003