Publications by authors named "Harpreet K Saini"

16Publications

Dual-Mechanism ERK1/2 Inhibitors Exploit a Distinct Binding Mode to Block Phosphorylation and Nuclear Accumulation of ERK1/2.

Authors:
Andrew M Kidger Joanne M Munck Harpreet K Saini Kathryn Balmanno Emma Minihane Aurelie Courtin Brent Graham Marc O'Reilly Richard Odle Simon J Cook

Mol Cancer Ther 2020 02 20;19(2):525-539. Epub 2019 Nov 20.

Signalling Laboratory, The Babraham Institute, Babraham Research Campus, Cambridge, United Kingdom.

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February 2020

Visualization and analysis of RNA-Seq assembly graphs.

Authors:
Fahmi W Nazarie Barbara Shih Tim Angus Mark W Barnett Sz-Hau Chen Kim M Summers Karsten Klein Geoffrey J Faulkner Harpreet K Saini Mick Watson Stijn van Dongen Anton J Enright Tom C Freeman

Nucleic Acids Res 2019 08;47(14):7262-7275

Systems Immunology Group, The Roslin Institute and Royal (Dick) School of Veterinary Studies, The University of Edinburgh, Edinburgh EH25 9RG, UK.

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August 2019

COSMIC-3D provides structural perspectives on cancer genetics for drug discovery.

Authors:
Harry C Jubb Harpreet K Saini Marcel L Verdonk Simon A Forbes

Nat Genet 2018 09;50(9):1200-1202

COSMIC, Wellcome Sanger Institute, Cambridge, UK.

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September 2018

Extracellular vesicles are independent metabolic units with asparaginase activity.

Authors:
Nunzio Iraci Edoardo Gaude Tommaso Leonardi Ana S H Costa Chiara Cossetti Luca Peruzzotti-Jametti Joshua D Bernstock Harpreet K Saini Maurizio Gelati Angelo Luigi Vescovi Carlos Bastos Nuno Faria Luigi G Occhipinti Anton J Enright Christian Frezza Stefano Pluchino

Nat Chem Biol 2017 Sep 3;13(9):951-955. Epub 2017 Jul 3.

Wellcome Trust-Medical Research Council Stem Cell Institute, Department of Clinical Neurosciences-Division of Stem Cell Neurobiology, and NIHR Biomedical Research Centre, University of Cambridge, Cambridge, UK.

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September 2017

Transposon-driven transcription is a conserved feature of vertebrate spermatogenesis and transcript evolution.

Authors:
Matthew P Davis Claudia Carrieri Harpreet K Saini Stijn van Dongen Tommaso Leonardi Giovanni Bussotti Jack M Monahan Tania Auchynnikava Angelo Bitetti Juri Rappsilber Robin C Allshire Alena Shkumatava Dónal O'Carroll Anton J Enright

EMBO Rep 2017 07 12;18(7):1231-1247. Epub 2017 May 12.

European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Cambridge, UK

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July 2017

Emergence of resistance to tyrosine kinase inhibitors in non-small-cell lung cancer can be delayed by an upfront combination with the HSP90 inhibitor onalespib.

Authors:
Aurelie Courtin Tomoko Smyth Keisha Hearn Harpreet K Saini Neil T Thompson John F Lyons Nicola G Wallis

Br J Cancer 2016 Oct 27;115(9):1069-1077. Epub 2016 Sep 27.

Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge, CB4 0QA, UK.

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October 2016

Detection of secondary binding sites in proteins using fragment screening.

Authors:
R Frederick Ludlow Marcel L Verdonk Harpreet K Saini Ian J Tickle Harren Jhoti

Proc Natl Acad Sci U S A 2015 Dec 11;112(52):15910-5. Epub 2015 Dec 11.

Astex Pharmaceuticals, Cambridge CB4 0QA, United Kingdom

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December 2015

Solid tumors of childhood display specific serum microRNA profiles.

Authors:
Matthew J Murray Katie L Raby Harpreet K Saini Shivani Bailey Sophie V Wool Jane M Tunnacliffe Anton J Enright James C Nicholson Nicholas Coleman

Cancer Epidemiol Biomarkers Prev 2015 Feb 21;24(2):350-60. Epub 2014 Nov 21.

Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge, United Kingdom. Department of Histopathology, Addenbrooke's Hospital, Hills Road, Cambridge, United Kingdom.

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February 2015

Extracellular vesicles from neural stem cells transfer IFN-γ via Ifngr1 to activate Stat1 signaling in target cells.

Authors:
Chiara Cossetti Nunzio Iraci Tim R Mercer Tommaso Leonardi Emanuele Alpi Denise Drago Clara Alfaro-Cervello Harpreet K Saini Matthew P Davis Julia Schaeffer Beatriz Vega Matilde Stefanini CongJian Zhao Werner Muller Jose Manuel Garcia-Verdugo Suresh Mathivanan Angela Bachi Anton J Enright John S Mattick Stefano Pluchino

Mol Cell 2014 Oct 18;56(2):193-204. Epub 2014 Sep 18.

John van Geest Centre for Brain Repair, Department of Clinical Neurosciences, and NIHR Biomedical Research Centre, University of Cambridge, CB2 0PY Cambridge, UK; Wellcome Trust-Medical Research Council Stem Cell Institute, Cambridge, UK. Electronic address:

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October 2014

Integrated analysis of microRNA and mRNA expression and association with HIF binding reveals the complexity of microRNA expression regulation under hypoxia.

Authors:
Carme Camps Harpreet K Saini David R Mole Hani Choudhry Martin Reczko José Afonso Guerra-Assunção Ya-Min Tian Francesca M Buffa Adrian L Harris Artemis G Hatzigeorgiou Anton J Enright Jiannis Ragoussis

Mol Cancer 2014 Feb 11;13:28. Epub 2014 Feb 11.

The Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford, United Kingdom.

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February 2014

Depletion of HPV16 early genes induces autophagy and senescence in a cervical carcinogenesis model, regardless of viral physical state.

Authors:
Jennifer E Hanning Harpreet K Saini Matthew J Murray Maria M Caffarel Stijn van Dongen Dawn Ward Emily M Barker Cinzia G Scarpini Ian J Groves Margaret A Stanley Anton J Enright Mark R Pett Nicholas Coleman

J Pathol 2013 Nov;231(3):354-66

Department of Pathology, University of Cambridge, CB2 1QP, UK.

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November 2013

LIN28 Expression in malignant germ cell tumors downregulates let-7 and increases oncogene levels.

Authors:
Matthew J Murray Harpreet K Saini Charlotte A Siegler Jennifer E Hanning Emily M Barker Stijn van Dongen Dawn M Ward Katie L Raby Ian J Groves Cinzia G Scarpini Mark R Pett Claire M Thornton Anton J Enright James C Nicholson Nicholas Coleman

Cancer Res 2013 Aug 17;73(15):4872-84. Epub 2013 Jun 17.

Department of Pathology, Cambridge University, Cambridge, United Kingdom.

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August 2013

The two most common histological subtypes of malignant germ cell tumour are distinguished by global microRNA profiles, associated with differential transcription factor expression.

Authors:
Matthew J Murray Harpreet K Saini Stijn van Dongen Roger D Palmer Balaji Muralidhar Mark R Pett Matias Piipari Claire M Thornton James C Nicholson Anton J Enright Nicholas Coleman

Mol Cancer 2010 Nov 8;9:290. Epub 2010 Nov 8.

Medical Research Council Cancer Cell Unit, Cambridge, CB2 0XZ, UK.

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November 2010

Malignant germ cell tumors display common microRNA profiles resulting in global changes in expression of messenger RNA targets.

Authors:
Roger D Palmer Matthew J Murray Harpreet K Saini Stijn van Dongen Cei Abreu-Goodger Balaji Muralidhar Mark R Pett Claire M Thornton James C Nicholson Anton J Enright Nicholas Coleman

Cancer Res 2010 Apr 23;70(7):2911-23. Epub 2010 Mar 23.

Medical Research Council Cancer Cell Unit, Hills Road, Cambridge CB2 0XZ, United Kingdom.

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April 2010

Annotation of mammalian primary microRNAs.

Authors:
Harpreet K Saini Anton J Enright Sam Griffiths-Jones

BMC Genomics 2008 Nov 27;9:564. Epub 2008 Nov 27.

Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK.

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November 2008

Computational prediction of protein-protein interactions.

Authors:
Lucy Skrabanek Harpreet K Saini Gary D Bader Anton J Enright

Mol Biotechnol 2008 Jan 14;38(1):1-17. Epub 2007 Aug 14.

Department of Physiology and Biophysics and Institute for Computational Biomedicine, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA.

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January 2008