Publications by authors named "Harold F Dvorak"

50Publications

Tumors: Wounds That Do Not Heal-A Historical Perspective with a Focus on the Fundamental Roles of Increased Vascular Permeability and Clotting.

Authors:
Harold F Dvorak

Semin Thromb Hemost 2019 Sep 16;45(6):576-592. Epub 2019 May 16.

Center for Vascular Biology Research and the Departments of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts.

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September 2019

Early Actions of Anti-Vascular Endothelial Growth Factor/Vascular Endothelial Growth Factor Receptor Drugs on Angiogenic Blood Vessels.

Am J Pathol 2017 Oct 21;187(10):2337-2347. Epub 2017 Jul 21.

The Center for Vascular Biology Research and the Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts. Electronic address:

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October 2017

Intracellular distribution of TM4SF1 and internalization of TM4SF1-antibody complex in vascular endothelial cells.

Biochem Biophys Res Commun 2015 Sep 1;465(3):338-43. Epub 2015 Aug 1.

Center for Vascular Biology Research and Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, USA. Electronic address:

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September 2015

Tumor Stroma, Tumor Blood Vessels, and Antiangiogenesis Therapy.

Authors:
Harold F Dvorak

Cancer J 2015 Jul-Aug;21(4):237-43

From the Center for Vascular Biology Research and the Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA.

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May 2016

Tumors: wounds that do not heal-redux.

Authors:
Harold F Dvorak

Cancer Immunol Res 2015 Jan;3(1):1-11

The Center for Vascular Biology Research and the Departments of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts.

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January 2015

Role of BRAFV600E in the first preclinical model of multifocal infiltrating myopericytoma development and microenvironment.

J Natl Cancer Inst 2014 Aug 25;106(8). Epub 2014 Jul 25.

Department of Pathology, Massachusetts General Hospital (PMS) and Department of Medicine, Brigham and Women's Hospital (CP, EPH), Harvard Medical School, Boston, MA; Unit of Endocrinology, Department of Medicine, A. Gemelli, Catholic University, Roma, Italy (SN, AP); Division of Cancer Genetics, Department of Medicine (FAK, JC, PPP) and Laboratory of Human Thyroid Cancers Preclinical and Translational Research, Division of Cancer Biology and Angiogenesis, Department of Pathology, Center for Vascular Biology Research (MD, CN), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA; Department of Medicine (RM, CVC) and Department of Pathology (AH, HD, JL), Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Boston, MA; Dermatopathologische Gemeinschaftspraxis, Siemensstrasse, Friedri chshafen, Germany (HK, TM); National Research Council (CNR-IBCN) and Department of Experimental Oncology, Regina Elena Cancer Institute, Rome, Italy (AF); Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA (EP, LEM); MIT/Broad Institute, Cambridge, MA (EP, LEM); Department of Plastic and Reconstructive Surgery, National Health Insurance Service Ilsan Hospital, Ilsan, Korea (SC); Department of Pathology (GF) and Department of Surgery (CPL), A. Gemelli, Catholic University, Roma, Italy; Department of Experimental and Clinical Medicine (AMDA) and Unit of Radiotherapy (OD), University of Catanzaro, Italy; Department of Nuclear Medicine, Beth Israel Deaconess Medical Center (JAP); Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (CF).

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August 2014

TM4SF1: a new vascular therapeutic target in cancer.

Angiogenesis 2014 Oct 2;17(4):897-907. Epub 2014 Jul 2.

The Center for Vascular Biology Research, Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, RN-280D, Boston, MA, 02215, USA.

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October 2014

Heterogeneity of the tumor vasculature: the need for new tumor blood vessel type-specific targets.

Clin Exp Metastasis 2012 Oct 13;29(7):657-62. Epub 2012 Jun 13.

Departments of Pathology, The Center for Vascular Biology Research, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Ave, RN227C, Boston, MA 02215, USA.

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October 2012

Anti-VEGF/VEGFR therapy for cancer: reassessing the target.

Cancer Res 2012 Apr;72(8):1909-14

The Center for Vascular Biology Research, Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA.

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April 2012

Vascular hyperpermeability, angiogenesis, and stroma generation.

Cold Spring Harb Perspect Med 2012 Feb;2(2):a006544

Center for Vascular Biology Research and the Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02115, USA.

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February 2012

Tumor-surrogate blood vessel subtypes exhibit differential susceptibility to anti-VEGF therapy.

Cancer Res 2011 Nov 21;71(22):7021-8. Epub 2011 Sep 21.

The Center for Vascular Biology Research and Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA.

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November 2011

Orphan nuclear transcription factor TR3/Nur77 regulates microvessel permeability by targeting endothelial nitric oxide synthase and destabilizing endothelial junctions.

Proc Natl Acad Sci U S A 2011 Jul 5;108(29):12066-71. Epub 2011 Jul 5.

Division of Gastroenterology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA.

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July 2011

TM4SF1: a tetraspanin-like protein necessary for nanopodia formation and endothelial cell migration.

Angiogenesis 2011 Sep 29;14(3):345-54. Epub 2011 May 29.

Center for Vascular Biology Research, Department of Pathology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.

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September 2011

Tumor microenvironment and progression.

J Surg Oncol 2011 May;103(6):468-74

Department of Pathology, Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.

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May 2011

Proteolytic cleavage of versican and involvement of ADAMTS-1 in VEGF-A/VPF-induced pathological angiogenesis.

J Histochem Cytochem 2011 May 16;59(5):463-73. Epub 2011 Mar 16.

The Center for Vascular Biology Research and Departments of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA.

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May 2011

A multi-gene transcriptional profiling approach to the discovery of cell signature markers.

Cytotechnology 2011 Jan 23;63(1):25-33. Epub 2010 Oct 23.

Center for Vascular Biological Research and Division of Molecular and Vascular Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, 99 Brookline Avenue, Boston, MA, 02215, USA.

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January 2011

My friend Marty.

Authors:
Harold F Dvorak

J Cutan Pathol 2010 Apr;37 Suppl 1:6-7

Center for Vascular Biology Research, Department of Pathology, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.

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April 2010

Heterogeneity of the tumor vasculature.

Semin Thromb Hemost 2010 Apr 20;36(3):321-31. Epub 2010 May 20.

Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.

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April 2010

Vascular permeability to plasma, plasma proteins, and cells: an update.

Authors:
Harold F Dvorak

Curr Opin Hematol 2010 May;17(3):225-9

Center for Vascular Biology Research and the Department of Pathology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.

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May 2010

Vascular permeability and pathological angiogenesis in caveolin-1-null mice.

Am J Pathol 2009 Oct 3;175(4):1768-76. Epub 2009 Sep 3.

Center for Vascular Biology Research and the Departments of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA.

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October 2009

Thrombospondin-1 modulates vascular endothelial growth factor activity at the receptor level.

FASEB J 2009 Oct 15;23(10):3368-76. Epub 2009 Jun 15.

Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA.

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October 2009

Rapamycin inhibition of the Akt/mTOR pathway blocks select stages of VEGF-A164-driven angiogenesis, in part by blocking S6Kinase.

Arterioscler Thromb Vasc Biol 2009 Aug 14;29(8):1172-8. Epub 2009 May 14.

Center for Vascular Biology and the Department of Pathology at the Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.

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August 2009

The L6 protein TM4SF1 is critical for endothelial cell function and tumor angiogenesis.

Cancer Res 2009 Apr 7;69(8):3272-7. Epub 2009 Apr 7.

Center for Vascular Biological Research and Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA.

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April 2009

Chapter 3. The adenoviral vector angiogenesis/lymphangiogenesis assay.

Methods Enzymol 2008 ;444:43-64

Department of Pathology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.

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January 2009

Vascular permeability, vascular hyperpermeability and angiogenesis.

Angiogenesis 2008 22;11(2):109-19. Epub 2008 Feb 22.

Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.

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September 2008

VEGF-A and the induction of pathological angiogenesis.

Annu Rev Pathol 2007 ;2:251-75

Department of Pathology and Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA.

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August 2008

Transcellular diapedesis is initiated by invasive podosomes.

Immunity 2007 Jun;26(6):784-97

The CBR Institute for Biomedical Research, Department of Pathology, Harvard Medical School, Boston, MA 02115, USA.

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June 2007

Distinct vascular endothelial growth factor signals for lymphatic vessel enlargement and sprouting.

J Exp Med 2007 Jun 29;204(6):1431-40. Epub 2007 May 29.

Molecular/Cancer Biology Laboratory and Ludwig Institute for Cancer Research, Haartman Institute and Helsinki University Hospital, Biomedicum Helsinki, University of Helsinki, 00014 Helsinki, Finland.

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June 2007

Down syndrome candidate region 1 isoform 1 mediates angiogenesis through the calcineurin-NFAT pathway.

Mol Cancer Res 2006 Nov;4(11):811-20

Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, 99 Brookline Avenue RN 270A, Boston, MA 02215, USA.

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November 2006

Permeability properties of tumor surrogate blood vessels induced by VEGF-A.

Lab Invest 2006 Aug 29;86(8):767-80. Epub 2006 May 29.

Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA.

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August 2006

Orphan nuclear receptor TR3/Nur77 regulates VEGF-A-induced angiogenesis through its transcriptional activity.

J Exp Med 2006 Mar 6;203(3):719-29. Epub 2006 Mar 6.

Department of Pathology, Gastroenterology Division, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA.

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March 2006

Discovery of vascular permeability factor (VPF).

Authors:
Harold F Dvorak

Exp Cell Res 2006 Mar 20;312(5):522-6. Epub 2006 Jan 20.

Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, 99 Brookline Avenue, Boston, MA 02215, USA.

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March 2006

Inhibition of vessel permeability by TNP-470 and its polymer conjugate, caplostatin.

Cancer Cell 2005 Mar;7(3):251-61

Children's Hospital Boston and Harvard Medical School, Vascular Biology Program, Department of Surgery, 1 Blackfan Circle, Karp Family Research Laboratories, Floor 12, Boston, Massachusetts 02115, USA.

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March 2005

Ultrastructural localization of platelet endothelial cell adhesion molecule (PECAM-1, CD31) in vascular endothelium.

J Histochem Cytochem 2004 Jan;52(1):87-101

Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA.

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January 2004

VEGF-A(164/165) and PlGF: roles in angiogenesis and arteriogenesis.

Trends Cardiovasc Med 2003 Jul;13(5):169-75

Department of Pathology, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA.

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July 2003

Rous-Whipple Award Lecture. How tumors make bad blood vessels and stroma.

Authors:
Harold F Dvorak

Am J Pathol 2003 Jun;162(6):1747-57

Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA.

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June 2003

Vascular permeability factor/vascular endothelial growth factor: a critical cytokine in tumor angiogenesis and a potential target for diagnosis and therapy.

Authors:
Harold F Dvorak

J Clin Oncol 2002 Nov;20(21):4368-80

Department of Pathology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.

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November 2002

Ultrastructural studies define soluble macromolecular, particulate, and cellular transendothelial cell pathways in venules, lymphatic vessels, and tumor-associated microvessels in man and animals.

Microsc Res Tech 2002 Jun;57(5):289-326

Department of Pathology, Beth Israel Deaconess Medical Center, and Harvard Medical School, Boston, Massachusetts 02215, USA.

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June 2002