Harm Jan Westra

Harm Jan Westra

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Harm Jan Westra

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Genetic associations with radiological damage in rheumatoid arthritis: Meta-analysis of seven genome-wide association studies of 2,775 cases.

Authors:
Matthew Traylor Rachel Knevel Jing Cui John Taylor Westra Harm-Jan Philip G Conaghan Andrew P Cope Charles Curtis Paul Emery Stephen Newhouse Hamel Patel Sophia Steer Peter Gregersen Nancy A Shadick Michael E Weinblatt Annette Van Der Helm-van Mil Jennifer H Barrett Ann W Morgan Cathryn M Lewis Ian C Scott

PLoS One 2019 9;14(10):e0223246. Epub 2019 Oct 9.

Primary Care Centre Versus Arthritis, Research Institute for Primary Care and Health Sciences, Primary Care Sciences, Keele University, Keele, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0223246PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6785117PMC
October 2019

IMPACT: Genomic Annotation of Cell-State-Specific Regulatory Elements Inferred from the Epigenome of Bound Transcription Factors.

Authors:
Tiffany Amariuta Yang Luo Steven Gazal Emma E Davenport Bryce van de Geijn Kazuyoshi Ishigaki Harm-Jan Westra Nikola Teslovich Yukinori Okada Kazuhiko Yamamoto Alkes L Price Soumya Raychaudhuri

Am J Hum Genet 2019 May 18;104(5):879-895. Epub 2019 Apr 18.

Center for Data Sciences, Harvard Medical School, Boston, MA 02115, USA; Divisions of Genetics and Rheumatology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Biomedical Informatics, Harvard Medical School, Boston, MA 02115, USA; Graduate School of Arts and Sciences, Harvard University, Cambridge, MA 02138, USA; Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00029297193010
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http://dx.doi.org/10.1016/j.ajhg.2019.03.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6506796PMC
May 2019

An integrative approach for building personalized gene regulatory networks for precision medicine.

Authors:
Monique G P van der Wijst Dylan H de Vries Harm Brugge Harm-Jan Westra Lude Franke

Genome Med 2018 12 19;10(1):96. Epub 2018 Dec 19.

Department of Genetics, 5th floor ERIBA building, Antonius Deusinglaan 1, 9713AV Groningen, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

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https://genomemedicine.biomedcentral.com/articles/10.1186/s1
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http://dx.doi.org/10.1186/s13073-018-0608-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299585PMC
December 2018

Fine-mapping and functional studies highlight potential causal variants for rheumatoid arthritis and type 1 diabetes.

Authors:
Harm-Jan Westra Marta Martínez-Bonet Suna Onengut-Gumuscu Annette Lee Yang Luo Nikola Teslovich Jane Worthington Javier Martin Tom Huizinga Lars Klareskog Solbritt Rantapaa-Dahlqvist Wei-Min Chen Aaron Quinlan John A Todd Steve Eyre Peter A Nigrovic Peter K Gregersen Stephen S Rich Soumya Raychaudhuri

Nat Genet 2018 10 17;50(10):1366-1374. Epub 2018 Sep 17.

Center for Data Sciences, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

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http://www.nature.com/articles/s41588-018-0216-7
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http://dx.doi.org/10.1038/s41588-018-0216-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364548PMC
October 2018

Discovering in vivo cytokine-eQTL interactions from a lupus clinical trial.

Authors:
Emma E Davenport Tiffany Amariuta Maria Gutierrez-Arcelus Kamil Slowikowski Harm-Jan Westra Yang Luo Ciyue Shen Deepak A Rao Ying Zhang Stephen Pearson David von Schack Jean S Beebe Nan Bing Sally John Michael S Vincent Baohong Zhang Soumya Raychaudhuri

Genome Biol 2018 10 19;19(1):168. Epub 2018 Oct 19.

Center for Data Sciences, Brigham and Women's Hospital, Boston, MA, 02115, USA.

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https://genomebiology.biomedcentral.com/articles/10.1186/s13
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http://dx.doi.org/10.1186/s13059-018-1560-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6195724PMC
October 2018

High-throughput identification of noncoding functional SNPs via type IIS enzyme restriction.

Authors:
Gang Li Marta Martínez-Bonet Di Wu Yu Yang Jing Cui Hung N Nguyen Pierre Cunin Anaïs Levescot Ming Bai Harm-Jan Westra Yukinori Okada Michael B Brenner Soumya Raychaudhuri Eric A Hendrickson Richard L Maas Peter A Nigrovic

Nat Genet 2018 08 16;50(8):1180-1188. Epub 2018 Jul 16.

Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1038/s41588-018-0159-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6072570PMC
August 2018

PR interval genome-wide association meta-analysis identifies 50 loci associated with atrial and atrioventricular electrical activity.

Authors:
Jessica van Setten Jennifer A Brody Yalda Jamshidi Brenton R Swenson Anne M Butler Harry Campbell Fabiola M Del Greco Daniel S Evans Quince Gibson Daniel F Gudbjartsson Kathleen F Kerr Bouwe P Krijthe Leo-Pekka Lyytikäinen Christian Müller Martina Müller-Nurasyid Ilja M Nolte Sandosh Padmanabhan Marylyn D Ritchie Antonietta Robino Albert V Smith Maristella Steri Toshiko Tanaka Alexander Teumer Stella Trompet Sheila Ulivi Niek Verweij Xiaoyan Yin David O Arnar Folkert W Asselbergs Joel S Bader John Barnard Josh Bis Stefan Blankenberg Eric Boerwinkle Yuki Bradford Brendan M Buckley Mina K Chung Dana Crawford Marcel den Hoed Josh C Denny Anna F Dominiczak Georg B Ehret Mark Eijgelsheim Patrick T Ellinor Stephan B Felix Oscar H Franco Lude Franke Tamara B Harris Hilma Holm Gandin Ilaria Annamaria Iorio Mika Kähönen Ivana Kolcic Jan A Kors Edward G Lakatta Lenore J Launer Honghuang Lin Henry J Lin Ruth J F Loos Steven A Lubitz Peter W Macfarlane Jared W Magnani Irene Mateo Leach Thomas Meitinger Braxton D Mitchell Thomas Munzel George J Papanicolaou Annette Peters Arne Pfeufer Peter P Pramstaller Olli T Raitakari Jerome I Rotter Igor Rudan Nilesh J Samani David Schlessinger Claudia T Silva Aldana Moritz F Sinner Jonathan D Smith Harold Snieder Elsayed Z Soliman Timothy D Spector David J Stott Konstantin Strauch Kirill V Tarasov Unnur Thorsteinsdottir Andre G Uitterlinden David R Van Wagoner Uwe Völker Henry Völzke Melanie Waldenberger Harm Jan Westra Philipp S Wild Tanja Zeller Alvaro Alonso Christy L Avery Stefania Bandinelli Emelia J Benjamin Francesco Cucca Marcus Dörr Luigi Ferrucci Paolo Gasparini Vilmundur Gudnason Caroline Hayward Susan R Heckbert Andrew A Hicks J Wouter Jukema Stefan Kääb Terho Lehtimäki Yongmei Liu Patricia B Munroe Afshin Parsa Ozren Polasek Bruce M Psaty Dan M Roden Renate B Schnabel Gianfranco Sinagra Kari Stefansson Bruno H Stricker Pim van der Harst Cornelia M van Duijn James F Wilson Sina A Gharib Paul I W de Bakker Aaron Isaacs Dan E Arking Nona Sotoodehnia

Nat Commun 2018 07 25;9(1):2904. Epub 2018 Jul 25.

Departments of Medicine and Epidemiology, Cardiovascular Health Research Unit, Division of Cardiology, University of Washington, Seattle, 98101, WA, USA.

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http://dx.doi.org/10.1038/s41467-018-04766-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6060178PMC
July 2018

reGenotyper: Detecting mislabeled samples in genetic data.

Authors:
Konrad Zych Basten L Snoek Mark Elvin Miriam Rodriguez K Joeri Van der Velde Danny Arends Harm-Jan Westra Morris A Swertz Gino Poulin Jan E Kammenga Rainer Breitling Ritsert C Jansen Yang Li

PLoS One 2017 13;12(2):e0171324. Epub 2017 Feb 13.

Groningen Bioinformatics Centre, University of Groningen, Groningen, The Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0171324PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5305221PMC
August 2017

Pathogenic implications for autoimmune mechanisms derived by comparative eQTL analysis of CD4+ versus CD8+ T cells.

Authors:
Silva Kasela Kai Kisand Liina Tserel Epp Kaleviste Anu Remm Krista Fischer Tõnu Esko Harm-Jan Westra Benjamin P Fairfax Seiko Makino Julian C Knight Lude Franke Andres Metspalu Pärt Peterson Lili Milani

PLoS Genet 2017 Mar 1;13(3):e1006643. Epub 2017 Mar 1.

Estonian Genome Center, University of Tartu, Tartu, Estonia.

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http://dx.doi.org/10.1371/journal.pgen.1006643DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5352142PMC
March 2017

Identification of context-dependent expression quantitative trait loci in whole blood.

Authors:
Daria V Zhernakova Patrick Deelen Martijn Vermaat Maarten van Iterson Michiel van Galen Wibowo Arindrarto Peter van 't Hof Hailiang Mei Freerk van Dijk Harm-Jan Westra Marc Jan Bonder Jeroen van Rooij Marijn Verkerk P Mila Jhamai Matthijs Moed Szymon M Kielbasa Jan Bot Irene Nooren René Pool Jenny van Dongen Jouke J Hottenga Coen D A Stehouwer Carla J H van der Kallen Casper G Schalkwijk Alexandra Zhernakova Yang Li Ettje F Tigchelaar Niek de Klein Marian Beekman Joris Deelen Diana van Heemst Leonard H van den Berg Albert Hofman André G Uitterlinden Marleen M J van Greevenbroek Jan H Veldink Dorret I Boomsma Cornelia M van Duijn Cisca Wijmenga P Eline Slagboom Morris A Swertz Aaron Isaacs Joyce B J van Meurs Rick Jansen Bastiaan T Heijmans Peter A C 't Hoen Lude Franke

Nat Genet 2017 01 5;49(1):139-145. Epub 2016 Dec 5.

University of Groningen, University Medical Center Groningen, Genomics Coordination Center, Groningen, the Netherlands.

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http://dx.doi.org/10.1038/ng.3737DOI Listing
January 2017

Corrigendum: Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses.

Authors:
Aysu Okbay Bart M L Baselmans Jan-Emmanuel De Neve Patrick Turley Michel G Nivard Mark Alan Fontana S Fleur W Meddens Richard Karlsson Linnér Cornelius A Rietveld Jaime Derringer Jacob Gratten James J Lee Jimmy Z Liu Ronald de Vlaming Tarunveer S Ahluwalia Jadwiga Buchwald Alana Cavadino Alexis C Frazier-Wood Nicholas A Furlotte Victoria Garfield Marie Henrike Geisel Juan R Gonzalez Saskia Haitjema Robert Karlsson Sander W van der Laan Karl-Heinz Ladwig Jari Lahti Sven J van der Lee Penelope A Lind Tian Liu Lindsay Matteson Evelin Mihailov Michael B Miller Camelia C Minica Ilja M Nolte Dennis Mook-Kanamori Peter J van der Most Christopher Oldmeadow Yong Qian Olli Raitakari Rajesh Rawal Anu Realo Rico Rueedi Börge Schmidt Albert V Smith Evie Stergiakouli Toshiko Tanaka Kent Taylor Gudmar Thorleifsson Juho Wedenoja Juergen Wellmann Harm-Jan Westra Sara M Willems Wei Zhao Najaf Amin Andrew Bakshi Sven Bergmann Gyda Bjornsdottir Patricia A Boyle Samantha Cherney Simon R Cox Gail Davies Oliver S P Davis Jun Ding Nese Direk Peter Eibich Rebecca T Emeny Ghazaleh Fatemifar Jessica D Faul Luigi Ferrucci Andreas J Forstner Christian Gieger Richa Gupta Tamara B Harris Juliette M Harris Elizabeth G Holliday Jouke-Jan Hottenga Philip L De Jager Marika A Kaakinen Eero Kajantie Ville Karhunen Ivana Kolcic Meena Kumari Lenore J Launer Lude Franke Ruifang Li-Gao David C Liewald Marisa Koini Anu Loukola Pedro Marques-Vidal Grant W Montgomery Miriam A Mosing Lavinia Paternoster Alison Pattie Katja E Petrovic Laura Pulkki-Råback Lydia Quaye Katri Räikkönen Igor Rudan Rodney J Scott Jennifer A Smith Angelina R Sutin Maciej Trzaskowski Anna E Vinkhuyzen Lei Yu Delilah Zabaneh John R Attia David A Bennett Klaus Berger Lars Bertram Dorret I Boomsma Harold Snieder Shun-Chiao Chang Francesco Cucca Ian J Deary Cornelia M van Duijn Johan G Eriksson Ute Bültmann Eco J C de Geus Patrick J F Groenen Vilmundur Gudnason Torben Hansen Catharine A Hartman Claire M A Haworth Caroline Hayward Andrew C Heath David A Hinds Elina Hyppönen William G William Marjo-Riitta Järvelin Karl-Heinz Jöckel Jaakko Kaprio Sharon L R Kardia Liisa Keltikangas-Järvinen Peter Kraft Laura D Kubzansky Terho Lehtimäki Patrik K E Magnusson Nicholas G Martin Matt McGue Andres Metspalu Melinda Mills Renée de Mutsert Albertine J Oldehinkel Gerard Pasterkamp Nancy L Pedersen Robert Plomin Ozren Polasek Christine Power Stephen S Rich Frits R Rosendaal Hester M den Ruijter David Schlessinger Helena Schmidt Rauli Svento Reinhold Schmidt Behrooz Z Alizadeh Thorkild I A Sørensen Tim D Spector John M Starr Kari Stefansson Andrew Steptoe Antonio Terracciano Unnur Thorsteinsdottir A Roy Thurik Nicholas J Timpson Henning Tiemeier André G Uitterlinden Peter Vollenweider Gert G Wagner David R Weir Jian Yang Dalton C Conley George Davey Smith Albert Hofman Magnus Johannesson David I Laibson Sarah E Medland Michelle N Meyer Joseph K Pickrell Tõnu Esko Robert F Krueger Jonathan P Beauchamp Philipp D Koellinger Daniel J Benjamin Meike Bartels David Cesarini

Nat Genet 2016 11;48(12):1591

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http://dx.doi.org/10.1038/ng1216-1587bDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5509058PMC
November 2016

The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals.

Authors:
Georg B Ehret Teresa Ferreira Daniel I Chasman Anne U Jackson Ellen M Schmidt Toby Johnson Gudmar Thorleifsson Jian'an Luan Lousie A Donnelly Stavroula Kanoni Ann-Kristin Petersen Vasyl Pihur Rona J Strawbridge Dmitry Shungin Maria F Hughes Osorio Meirelles Marika Kaakinen Nabila Bouatia-Naji Kati Kristiansson Sonia Shah Marcus E Kleber Xiuqing Guo Leo-Pekka Lyytikäinen Cristiano Fava Niclas Eriksson Ilja M Nolte Patrik K Magnusson Elias L Salfati Loukianos S Rallidis Elizabeth Theusch Andrew J P Smith Lasse Folkersen Kate Witkowska Tune H Pers Roby Joehanes Stuart K Kim Lazaros Lataniotis Rick Jansen Andrew D Johnson Helen Warren Young Jin Kim Wei Zhao Ying Wu Bamidele O Tayo Murielle Bochud Devin Absher Linda S Adair Najaf Amin Dan E Arking Tomas Axelsson Damiano Baldassarre Beverley Balkau Stefania Bandinelli Michael R Barnes Inês Barroso Stephen Bevan Joshua C Bis Gyda Bjornsdottir Michael Boehnke Eric Boerwinkle Lori L Bonnycastle Dorret I Boomsma Stefan R Bornstein Morris J Brown Michel Burnier Claudia P Cabrera John C Chambers I-Shou Chang Ching-Yu Cheng Peter S Chines Ren-Hua Chung Francis S Collins John M Connell Angela Döring Jean Dallongeville John Danesh Ulf de Faire Graciela Delgado Anna F Dominiczak Alex S F Doney Fotios Drenos Sarah Edkins John D Eicher Roberto Elosua Stefan Enroth Jeanette Erdmann Per Eriksson Tonu Esko Evangelos Evangelou Alun Evans Tove Fall Martin Farrall Janine F Felix Jean Ferrières Luigi Ferrucci Myriam Fornage Terrence Forrester Nora Franceschini Oscar H Franco Duran Anders Franco-Cereceda Ross M Fraser Santhi K Ganesh He Gao Karl Gertow Francesco Gianfagna Bruna Gigante Franco Giulianini Anuj Goel Alison H Goodall Mark O Goodarzi Mathias Gorski Jürgen Gräßler Christopher Groves Vilmundur Gudnason Ulf Gyllensten Göran Hallmans Anna-Liisa Hartikainen Maija Hassinen Aki S Havulinna Caroline Hayward Serge Hercberg Karl-Heinz Herzig Andrew A Hicks Aroon D Hingorani Joel N Hirschhorn Albert Hofman Jostein Holmen Oddgeir Lingaas Holmen Jouke-Jan Hottenga Phil Howard Chao A Hsiung Steven C Hunt M Arfan Ikram Thomas Illig Carlos Iribarren Richard A Jensen Mika Kähönen Hyun Kang Sekar Kathiresan Brendan J Keating Kay-Tee Khaw Yun Kyoung Kim Eric Kim Mika Kivimaki Norman Klopp Genovefa Kolovou Pirjo Komulainen Jaspal S Kooner Gulum Kosova Ronald M Krauss Diana Kuh Zoltan Kutalik Johanna Kuusisto Kirsti Kvaløy Timo A Lakka Nanette R Lee I-Te Lee Wen-Jane Lee Daniel Levy Xiaohui Li Kae-Woei Liang Honghuang Lin Li Lin Jaana Lindström Stéphane Lobbens Satu Männistö Gabriele Müller Martina Müller-Nurasyid François Mach Hugh S Markus Eirini Marouli Mark I McCarthy Colin A McKenzie Pierre Meneton Cristina Menni Andres Metspalu Vladan Mijatovic Leena Moilanen May E Montasser Andrew D Morris Alanna C Morrison Antonella Mulas Ramaiah Nagaraja Narisu Narisu Kjell Nikus Christopher J O'Donnell Paul F O'Reilly Ken K Ong Fred Paccaud Cameron D Palmer Afshin Parsa Nancy L Pedersen Brenda W Penninx Markus Perola Annette Peters Neil Poulter Peter P Pramstaller Bruce M Psaty Thomas Quertermous Dabeeru C Rao Asif Rasheed N William N W R Rayner Frida Renström Rainer Rettig Kenneth M Rice Robert Roberts Lynda M Rose Jacques Rossouw Nilesh J Samani Serena Sanna Jouko Saramies Heribert Schunkert Sylvain Sebert Wayne H-H Sheu Young-Ah Shin Xueling Sim Johannes H Smit Albert V Smith Maria X Sosa Tim D Spector Alena Stančáková Alice Stanton Kathleen E Stirrups Heather M Stringham Johan Sundstrom Amy J Swift Ann-Christine Syvänen E-Shyong Tai Toshiko Tanaka Kirill V Tarasov Alexander Teumer Unnur Thorsteinsdottir Martin D Tobin Elena Tremoli Andre G Uitterlinden Matti Uusitupa Ahmad Vaez Dhananjay Vaidya Cornelia M van Duijn Erik P A van Iperen Ramachandran S Vasan Germaine C Verwoert Jarmo Virtamo Veronique Vitart Benjamin F Voight Peter Vollenweider Aline Wagner Louise V Wain Nicholas J Wareham Hugh Watkins Alan B Weder Harm-Jan Westra Rainford Wilks Tom Wilsgaard James F Wilson Tien Y Wong Tsun-Po Yang Jie Yao Loic Yengo Weihua Zhang Jing Hua Zhao Xiaofeng Zhu Pascal Bovet Richard S Cooper Karen L Mohlke Danish Saleheen Jong-Young Lee Paul Elliott Hinco J Gierman Cristen J Willer Lude Franke G Kees Hovingh Kent D Taylor George Dedoussis Peter Sever Andrew Wong Lars Lind Themistocles L Assimes Inger Njølstad Peter Eh Schwarz Claudia Langenberg Harold Snieder Mark J Caulfield Olle Melander Markku Laakso Juha Saltevo Rainer Rauramaa Jaakko Tuomilehto Erik Ingelsson Terho Lehtimäki Kristian Hveem Walter Palmas Winfried März Meena Kumari Veikko Salomaa Yii-Der I Chen Jerome I Rotter Philippe Froguel Marjo-Riitta Jarvelin Edward G Lakatta Kari Kuulasmaa Paul W Franks Anders Hamsten H-Erich Wichmann Colin N A Palmer Kari Stefansson Paul M Ridker Ruth J F Loos Aravinda Chakravarti Panos Deloukas Andrew P Morris Christopher Newton-Cheh Patricia B Munroe

Nat Genet 2016 10 12;48(10):1171-1184. Epub 2016 Sep 12.

Clinical Pharmacology, William Harvey Research Institute, Queen Mary University of London, London, EC1M 6BQ, UK.

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http://dx.doi.org/10.1038/ng.3667DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5042863PMC
October 2016

52 Genetic Loci Influencing Myocardial Mass.

Authors:
Pim van der Harst Jessica van Setten Niek Verweij Georg Vogler Lude Franke Matthew T Maurano Xinchen Wang Irene Mateo Leach Mark Eijgelsheim Nona Sotoodehnia Caroline Hayward Rossella Sorice Osorio Meirelles Leo-Pekka Lyytikäinen Ozren Polašek Toshiko Tanaka Dan E Arking Sheila Ulivi Stella Trompet Martina Müller-Nurasyid Albert V Smith Marcus Dörr Kathleen F Kerr Jared W Magnani Fabiola Del Greco M Weihua Zhang Ilja M Nolte Claudia T Silva Sandosh Padmanabhan Vinicius Tragante Tõnu Esko Gonçalo R Abecasis Michiel E Adriaens Karl Andersen Phil Barnett Joshua C Bis Rolf Bodmer Brendan M Buckley Harry Campbell Megan V Cannon Aravinda Chakravarti Lin Y Chen Alessandro Delitala Richard B Devereux Pieter A Doevendans Anna F Dominiczak Luigi Ferrucci Ian Ford Christian Gieger Tamara B Harris Eric Haugen Matthias Heinig Dena G Hernandez Hans L Hillege Joel N Hirschhorn Albert Hofman Norbert Hubner Shih-Jen Hwang Annamaria Iorio Mika Kähönen Manolis Kellis Ivana Kolcic Ishminder K Kooner Jaspal S Kooner Jan A Kors Edward G Lakatta Kasper Lage Lenore J Launer Daniel Levy Alicia Lundby Peter W Macfarlane Dalit May Thomas Meitinger Andres Metspalu Stefania Nappo Silvia Naitza Shane Neph Alex S Nord Teresa Nutile Peter M Okin Jesper V Olsen Ben A Oostra Josef M Penninger Len A Pennacchio Tune H Pers Siegfried Perz Annette Peters Yigal M Pinto Arne Pfeufer Maria Grazia Pilia Peter P Pramstaller Bram P Prins Olli T Raitakari Soumya Raychaudhuri Ken M Rice Elizabeth J Rossin Jerome I Rotter Sebastian Schafer David Schlessinger Carsten O Schmidt Jobanpreet Sehmi Herman H W Silljé Gianfranco Sinagra Moritz F Sinner Kamil Slowikowski Elsayed Z Soliman Timothy D Spector Wilko Spiering John A Stamatoyannopoulos Ronald P Stolk Konstantin Strauch Sian-Tsung Tan Kirill V Tarasov Bosco Trinh Andre G Uitterlinden Malou van den Boogaard Cornelia M van Duijn Wiek H van Gilst Jorma S Viikari Peter M Visscher Veronique Vitart Uwe Völker Melanie Waldenberger Christian X Weichenberger Harm-Jan Westra Cisca Wijmenga Bruce H Wolffenbuttel Jian Yang Connie R Bezzina Patricia B Munroe Harold Snieder Alan F Wright Igor Rudan Laurie A Boyer Folkert W Asselbergs Dirk J van Veldhuisen Bruno H Stricker Bruce M Psaty Marina Ciullo Serena Sanna Terho Lehtimäki James F Wilson Stefania Bandinelli Alvaro Alonso Paolo Gasparini J Wouter Jukema Stefan Kääb Vilmundur Gudnason Stephan B Felix Susan R Heckbert Rudolf A de Boer Christopher Newton-Cheh Andrew A Hicks John C Chambers Yalda Jamshidi Axel Visel Vincent M Christoffels Aaron Isaacs Nilesh J Samani Paul I W de Bakker

J Am Coll Cardiol 2016 09;68(13):1435-1448

Department of Medical Genetics, University Medical Center Utrecht, Utrecht, the Netherlands; Department of Epidemiology, University Medical Center Utrecht, Utrecht, the Netherlands.

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http://dx.doi.org/10.1016/j.jacc.2016.07.729DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5478167PMC
September 2016

Corrigendum: Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses.

Authors:
Aysu Okbay Bart M L Baselmans Jan-Emmanuel De Neve Patrick Turley Michel G Nivard Mark Alan Fontana S Fleur W Meddens Richard Karlsson Linnér Cornelius A Rietveld Jaime Derringer Jacob Gratten James J Lee Jimmy Z Liu Ronald de Vlaming Tarunveer S Ahluwalia Jadwiga Buchwald Alana Cavadino Alexis C Frazier-Wood Nicholas A Furlotte Victoria Garfield Marie Henrike Geisel Juan R Gonzalez Saskia Haitjema Robert Karlsson Sander W van der Laan Karl-Heinz Ladwig Jari Lahti Sven J van der Lee Penelope A Lind Tian Liu Lindsay Matteson Evelin Mihailov Michael B Miller Camelia C Minica Ilja M Nolte Dennis Mook-Kanamori Peter J van der Most Christopher Oldmeadow Yong Qian Olli Raitakari Rajesh Rawal Anu Realo Rico Rueedi Börge Schmidt Albert V Smith Evie Stergiakouli Toshiko Tanaka Kent Taylor Gudmar Thorleifsson Juho Wedenoja Juergen Wellmann Harm-Jan Westra Sara M Willems Wei Zhao Najaf Amin Andrew Bakshi Sven Bergmann Gyda Bjornsdottir Patricia A Boyle Samantha Cherney Simon R Cox Gail Davies Oliver S P Davis Jun Ding Nese Direk Peter Eibich Rebecca T Emeny Ghazaleh Fatemifar Jessica D Faul Luigi Ferrucci Andreas J Forstner Christian Gieger Richa Gupta Tamara B Harris Juliette M Harris Elizabeth G Holliday Jouke-Jan Hottenga Philip L De Jager Marika A Kaakinen Eero Kajantie Ville Karhunen Ivana Kolcic Meena Kumari Lenore J Launer Lude Franke Ruifang Li-Gao David C Liewald Marisa Koini Anu Loukola Pedro Marques-Vidal Grant W Montgomery Miriam A Mosing Lavinia Paternoster Alison Pattie Katja E Petrovic Laura Pulkki-Råback Lydia Quaye Katri Räikkönen Igor Rudan Rodney J Scott Jennifer A Smith Angelina R Sutin Maciej Trzaskowski Anna E Vinkhuyzen Lei Yu Delilah Zabaneh John R Attia David A Bennett Klaus Berger Lars Bertram Dorret I Boomsma Harold Snieder Shun-Chiao Chang Francesco Cucca Ian J Deary Cornelia M van Duijn Johan G Eriksson Ute Bültmann Eco J C de Geus Patrick J F Groenen Vilmundur Gudnason Torben Hansen Catharine A Hartman Claire M A Haworth Caroline Hayward Andrew C Heath David A Hinds Elina Hyppönen William G Iacono Marjo-Riitta Järvelin Karl-Heinz Jöckel Jaakko Kaprio Sharon L R Kardia Liisa Keltikangas-Järvinen Peter Kraft Laura D Kubzansky Terho Lehtimäki Patrik K E Magnusson Nicholas G Martin Matt McGue Andres Metspalu Melinda Mills Renée de Mutsert Albertine J Oldehinkel Gerard Pasterkamp Nancy L Pedersen Robert Plomin Ozren Polasek Christine Power Stephen S Rich Frits R Rosendaal Hester M den Ruijter David Schlessinger Helena Schmidt Rauli Svento Reinhold Schmidt Behrooz Z Alizadeh Thorkild I A Sørensen Tim D Spector John M Starr Kari Stefansson Andrew Steptoe Antonio Terracciano Unnur Thorsteinsdottir A Roy Thurik Nicholas J Timpson Henning Tiemeier André G Uitterlinden Peter Vollenweider Gert G Wagner David R Weir Jian Yang Dalton C Conley George Davey Smith Albert Hofman Magnus Johannesson David I Laibson Sarah E Medland Michelle N Meyer Joseph K Pickrell Tõnu Esko Robert F Krueger Jonathan P Beauchamp Philipp D Koellinger Daniel J Benjamin Meike Bartels David Cesarini

Nat Genet 2016 07;48(8):970

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http://dx.doi.org/10.1038/ng0816-970cDOI Listing
July 2016

Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses.

Authors:
Aysu Okbay Bart M L Baselmans Jan-Emmanuel De Neve Patrick Turley Michel G Nivard Mark Alan Fontana S Fleur W Meddens Richard Karlsson Linnér Cornelius A Rietveld Jaime Derringer Jacob Gratten James J Lee Jimmy Z Liu Ronald de Vlaming Tarunveer S Ahluwalia Jadwiga Buchwald Alana Cavadino Alexis C Frazier-Wood Nicholas A Furlotte Victoria Garfield Marie Henrike Geisel Juan R Gonzalez Saskia Haitjema Robert Karlsson Sander W van der Laan Karl-Heinz Ladwig Jari Lahti Sven J van der Lee Penelope A Lind Tian Liu Lindsay Matteson Evelin Mihailov Michael B Miller Camelia C Minica Ilja M Nolte Dennis Mook-Kanamori Peter J van der Most Christopher Oldmeadow Yong Qian Olli Raitakari Rajesh Rawal Anu Realo Rico Rueedi Börge Schmidt Albert V Smith Evie Stergiakouli Toshiko Tanaka Kent Taylor Gudmar Thorleifsson Juho Wedenoja Juergen Wellmann Harm-Jan Westra Sara M Willems Wei Zhao Najaf Amin Andrew Bakshi Sven Bergmann Gyda Bjornsdottir Patricia A Boyle Samantha Cherney Simon R Cox Gail Davies Oliver S P Davis Jun Ding Nese Direk Peter Eibich Rebecca T Emeny Ghazaleh Fatemifar Jessica D Faul Luigi Ferrucci Andreas J Forstner Christian Gieger Richa Gupta Tamara B Harris Juliette M Harris Elizabeth G Holliday Jouke-Jan Hottenga Philip L De Jager Marika A Kaakinen Eero Kajantie Ville Karhunen Ivana Kolcic Meena Kumari Lenore J Launer Lude Franke Ruifang Li-Gao David C Liewald Marisa Koini Anu Loukola Pedro Marques-Vidal Grant W Montgomery Miriam A Mosing Lavinia Paternoster Alison Pattie Katja E Petrovic Laura Pulkki-Råback Lydia Quaye Katri Räikkönen Igor Rudan Rodney J Scott Jennifer A Smith Angelina R Sutin Maciej Trzaskowski Anna E Vinkhuyzen Lei Yu Delilah Zabaneh John R Attia David A Bennett Klaus Berger Lars Bertram Dorret I Boomsma Harold Snieder Shun-Chiao Chang Francesco Cucca Ian J Deary Cornelia M van Duijn Johan G Eriksson Ute Bültmann Eco J C de Geus Patrick J F Groenen Vilmundur Gudnason Torben Hansen Catharine A Hartman Claire M A Haworth Caroline Hayward Andrew C Heath David A Hinds Elina Hyppönen William G Iacono Marjo-Riitta Järvelin Karl-Heinz Jöckel Jaakko Kaprio Sharon L R Kardia Liisa Keltikangas-Järvinen Peter Kraft Laura D Kubzansky Terho Lehtimäki Patrik K E Magnusson Nicholas G Martin Matt McGue Andres Metspalu Melinda Mills Renée de Mutsert Albertine J Oldehinkel Gerard Pasterkamp Nancy L Pedersen Robert Plomin Ozren Polasek Christine Power Stephen S Rich Frits R Rosendaal Hester M den Ruijter David Schlessinger Helena Schmidt Rauli Svento Reinhold Schmidt Behrooz Z Alizadeh Thorkild I A Sørensen Tim D Spector John M Starr Kari Stefansson Andrew Steptoe Antonio Terracciano Unnur Thorsteinsdottir A Roy Thurik Nicholas J Timpson Henning Tiemeier André G Uitterlinden Peter Vollenweider Gert G Wagner David R Weir Jian Yang Dalton C Conley George Davey Smith Albert Hofman Magnus Johannesson David I Laibson Sarah E Medland Michelle N Meyer Joseph K Pickrell Tõnu Esko Robert F Krueger Jonathan P Beauchamp Philipp D Koellinger Daniel J Benjamin Meike Bartels David Cesarini

Nat Genet 2016 06 18;48(6):624-33. Epub 2016 Apr 18.

Department of Economics, New York University, New York, New York, USA.

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http://dx.doi.org/10.1038/ng.3552DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4884152PMC
June 2016

Correction: The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study.

Authors:
Thomas W Winkler Anne E Justice Mariaelisa Graff Llilda Barata Mary F Feitosa Su Chu Jacek Czajkowski Tõnu Esko Tove Fall Tuomas O Kilpeläinen Yingchang Lu Reedik Mägi Evelin Mihailov Tune H Pers Sina Rüeger Alexander Teumer Georg B Ehret Teresa Ferreira Nancy L Heard-Costa Juha Karjalainen Vasiliki Lagou Anubha Mahajan Michael D Neinast Inga Prokopenko Jeannette Simino Tanya M Teslovich Rick Jansen Harm-Jan Westra Charles C White Devin Absher Tarunveer S Ahluwalia Shafqat Ahmad Eva Albrecht Alexessander Couto Alves Jennifer L Bragg-Gresham Anton J M de Craen Joshua C Bis Amélie Bonnefond Gabrielle Boucher Gemma Cadby Yu-Ching Cheng Charleston W K Chiang Graciela Delgado Ayse Demirkan Nicole Dueker Niina Eklund Gudny Eiriksdottir Joel Eriksson Bjarke Feenstra Krista Fischer Francesca Frau Tessel E Galesloot Frank Geller Anuj Goel Mathias Gorski Tanja B Grammer Stefan Gustafsson Saskia Haitjema Jouke-Jan Hottenga Jennifer E Huffman Anne U Jackson Kevin B Jacobs Åsa Johansson Marika Kaakinen Marcus E Kleber Jari Lahti Irene Mateo Leach Benjamin Lehne Youfang Liu Ken Sin Lo Mattias Lorentzon Jian'an Luan Pamela A F Madden Massimo Mangino Barbara McKnight Carolina Medina-Gomez Keri L Monda May E Montasser Gabriele Müller Martina Müller-Nurasyid Ilja M Nolte Kalliope Panoutsopoulou Laura Pascoe Lavinia Paternoster Nigel W Rayner Frida Renström Federica Rizzi Lynda M Rose Kathy A Ryan Perttu Salo Serena Sanna Hubert Scharnagl Jianxin Shi Albert Vernon Smith Lorraine Southam Alena Stančáková Valgerdur Steinthorsdottir Rona J Strawbridge Yun Ju Sung Ioanna Tachmazidou Toshiko Tanaka Gudmar Thorleifsson Stella Trompet Natalia Pervjakova Jonathan P Tyrer Liesbeth Vandenput Sander W van der Laan Nathalie van der Velde Jessica van Setten Jana V van Vliet-Ostaptchouk Niek Verweij Efthymia Vlachopoulou Lindsay L Waite Sophie R Wang Zhaoming Wang Sarah H Wild Christina Willenborg James F Wilson Andrew Wong Jian Yang Loïc Yengo Laura M Yerges-Armstrong Lei Yu Weihua Zhang Jing Hua Zhao Ehm A Andersson Stephan J L Bakker Damiano Baldassarre Karina Banasik Matteo Barcella Cristina Barlassina Claire Bellis Paola Benaglio John Blangero Matthias Blüher Fabrice Bonnet Lori L Bonnycastle Heather A Boyd Marcel Bruinenberg Aron S Buchman Harry Campbell Yii-Der Ida Chen Peter S Chines Simone Claudi-Boehm John Cole Francis S Collins Eco J C de Geus Lisette C P G M de Groot Maria Dimitriou Jubao Duan Stefan Enroth Elodie Eury Aliki-Eleni Farmaki Nita G Forouhi Nele Friedrich Pablo V Gejman Bruna Gigante Nicola Glorioso Alan S Go Omri Gottesman Jürgen Gräßler Harald Grallert Niels Grarup Yu-Mei Gu Linda Broer Annelies C Ham Torben Hansen Tamara B Harris Catharina A Hartman Maija Hassinen Nicholas Hastie Andrew T Hattersley Andrew C Heath Anjali K Henders Dena Hernandez Hans Hillege Oddgeir Holmen Kees G Hovingh Jennie Hui Lise L Husemoen Nina Hutri-Kähönen Pirro G Hysi Thomas Illig Philip L De Jager Shapour Jalilzadeh Torben Jørgensen J Wouter Jukema Markus Juonala Stavroula Kanoni Maria Karaleftheri Kay Tee Khaw Leena Kinnunen Steven J Kittner Wolfgang Koenig Ivana Kolcic Peter Kovacs Nikolaj T Krarup Wolfgang Kratzer Janine Krüger Diana Kuh Meena Kumari Theodosios Kyriakou Claudia Langenberg Lars Lannfelt Chiara Lanzani Vaneet Lotay Lenore J Launer Karin Leander Jaana Lindström Allan Linneberg Yan-Ping Liu Stéphane Lobbens Robert Luben Valeriya Lyssenko Satu Männistö Patrik K Magnusson Wendy L McArdle Cristina Menni Sigrun Merger Lili Milani Grant W Montgomery Andrew P Morris Narisu Narisu Mari Nelis Ken K Ong Aarno Palotie Louis Pérusse Irene Pichler Maria G Pilia Anneli Pouta Myriam Rheinberger Rasmus Ribel-Madsen Marcus Richards Kenneth M Rice Treva K Rice Carlo Rivolta Veikko Salomaa Alan R Sanders Mark A Sarzynski Salome Scholtens Robert A Scott William R Scott Sylvain Sebert Sebanti Sengupta Bengt Sennblad Thomas Seufferlein Angela Silveira P Eline Slagboom Jan H Smit Thomas H Sparsø Kathleen Stirrups Ronald P Stolk Heather M Stringham Morris A Swertz Amy J Swift Ann-Christine Syvänen Sian-Tsung Tan Barbara Thorand Anke Tönjes Angelo Tremblay Emmanouil Tsafantakis Peter J van der Most Uwe Völker Marie-Claude Vohl Judith M Vonk Melanie Waldenberger Ryan W Walker Roman Wennauer Elisabeth Widén Gonneke Willemsen Tom Wilsgaard Alan F Wright M Carola Zillikens Suzanne C van Dijk Natasja M van Schoor Folkert W Asselbergs Paul I W de Bakker Jacques S Beckmann John Beilby David A Bennett Richard N Bergman Sven Bergmann Carsten A Böger Bernhard O Boehm Eric Boerwinkle Dorret I Boomsma Stefan R Bornstein Erwin P Bottinger Claude Bouchard John C Chambers Stephen J Chanock Daniel I Chasman Francesco Cucca Daniele Cusi George Dedoussis Jeanette Erdmann Johan G Eriksson Denis A Evans Ulf de Faire Martin Farrall Luigi Ferrucci Ian Ford Lude Franke Paul W Franks Philippe Froguel Ron T Gansevoort Christian Gieger Henrik Grönberg Vilmundur Gudnason Ulf Gyllensten Per Hall Anders Hamsten Pim van der Harst Caroline Hayward Markku Heliövaara Christian Hengstenberg Andrew A Hicks Aroon Hingorani Albert Hofman Frank Hu Heikki V Huikuri Kristian Hveem Alan L James Joanne M Jordan Antti Jula Mika Kähönen Eero Kajantie Sekar Kathiresan Lambertus A L M Kiemeney Mika Kivimaki Paul B Knekt Heikki A Koistinen Jaspal S Kooner Seppo Koskinen Johanna Kuusisto Winfried Maerz Nicholas G Martin Markku Laakso Timo A Lakka Terho Lehtimäki Guillaume Lettre Douglas F Levinson Lars Lind Marja-Liisa Lokki Pekka Mäntyselkä Mads Melbye Andres Metspalu Braxton D Mitchell Frans L Moll Jeffrey C Murray Arthur W Musk Markku S Nieminen Inger Njølstad Claes Ohlsson Albertine J Oldehinkel Ben A Oostra Lyle J Palmer James S Pankow Gerard Pasterkamp Nancy L Pedersen Oluf Pedersen Brenda W Penninx Markus Perola Annette Peters Ozren Polašek Peter P Pramstaller Bruce M Psaty Lu Qi Thomas Quertermous Olli T Raitakari Tuomo Rankinen Rainer Rauramaa Paul M Ridker John D Rioux Fernando Rivadeneira Jerome I Rotter Igor Rudan Hester M den Ruijter Juha Saltevo Naveed Sattar Heribert Schunkert Peter E H Schwarz Alan R Shuldiner Juha Sinisalo Harold Snieder Thorkild I A Sørensen Tim D Spector Jan A Staessen Bandinelli Stefania Unnur Thorsteinsdottir Michael Stumvoll Jean-Claude Tardif Elena Tremoli Jaakko Tuomilehto André G Uitterlinden Matti Uusitupa André L M Verbeek Sita H Vermeulen Jorma S Viikari Veronique Vitart Henry Völzke Peter Vollenweider Gérard Waeber Mark Walker Henri Wallaschofski Nicholas J Wareham Hugh Watkins Eleftheria Zeggini Aravinda Chakravarti Deborah J Clegg L Adrienne Cupples Penny Gordon-Larsen Cashell E Jaquish D C Rao Goncalo R Abecasis Themistocles L Assimes Inês Barroso Sonja I Berndt Michael Boehnke Panos Deloukas Caroline S Fox Leif C Groop David J Hunter Erik Ingelsson Robert C Kaplan Mark I McCarthy Karen L Mohlke Jeffrey R O'Connell David Schlessinger David P Strachan Kari Stefansson Cornelia M van Duijn Joel N Hirschhorn Cecilia M Lindgren Iris M Heid Kari E North Ingrid B Borecki Zoltán Kutalik Ruth J F Loos

PLoS Genet 2016 06 29;12(6):e1006166. Epub 2016 Jun 29.

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http://dx.doi.org/10.1371/journal.pgen.1006166DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4927064PMC
June 2016

Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci.

Authors:
David Ellinghaus Luke Jostins Sarah L Spain Adrian Cortes Jörn Bethune Buhm Han Yu Rang Park Soumya Raychaudhuri Jennie G Pouget Matthias Hübenthal Trine Folseraas Yunpeng Wang Tonu Esko Andres Metspalu Harm-Jan Westra Lude Franke Tune H Pers Rinse K Weersma Valerie Collij Mauro D'Amato Jonas Halfvarson Anders Boeck Jensen Wolfgang Lieb Franziska Degenhardt Andreas J Forstner Andrea Hofmann Stefan Schreiber Ulrich Mrowietz Brian D Juran Konstantinos N Lazaridis Søren Brunak Anders M Dale Richard C Trembath Stephan Weidinger Michael Weichenthal Eva Ellinghaus James T Elder Jonathan N W N Barker Ole A Andreassen Dermot P McGovern Tom H Karlsen Jeffrey C Barrett Miles Parkes Matthew A Brown Andre Franke

Nat Genet 2016 05 14;48(5):510-8. Epub 2016 Mar 14.

Institute of Clinical Molecular Biology, Christian Albrechts University of Kiel, Kiel, Germany.

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http://dx.doi.org/10.1038/ng.3528DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4848113PMC
May 2016

Genome-wide association study identifies 74 loci associated with educational attainment.

Authors:
Aysu Okbay Jonathan P Beauchamp Mark Alan Fontana James J Lee Tune H Pers Cornelius A Rietveld Patrick Turley Guo-Bo Chen Valur Emilsson S Fleur W Meddens Sven Oskarsson Joseph K Pickrell Kevin Thom Pascal Timshel Ronald de Vlaming Abdel Abdellaoui Tarunveer S Ahluwalia Jonas Bacelis Clemens Baumbach Gyda Bjornsdottir Johannes H Brandsma Maria Pina Concas Jaime Derringer Nicholas A Furlotte Tessel E Galesloot Giorgia Girotto Richa Gupta Leanne M Hall Sarah E Harris Edith Hofer Momoko Horikoshi Jennifer E Huffman Kadri Kaasik Ioanna P Kalafati Robert Karlsson Augustine Kong Jari Lahti Sven J van der Lee Christiaan deLeeuw Penelope A Lind Karl-Oskar Lindgren Tian Liu Massimo Mangino Jonathan Marten Evelin Mihailov Michael B Miller Peter J van der Most Christopher Oldmeadow Antony Payton Natalia Pervjakova Wouter J Peyrot Yong Qian Olli Raitakari Rico Rueedi Erika Salvi Börge Schmidt Katharina E Schraut Jianxin Shi Albert V Smith Raymond A Poot Beate St Pourcain Alexander Teumer Gudmar Thorleifsson Niek Verweij Dragana Vuckovic Juergen Wellmann Harm-Jan Westra Jingyun Yang Wei Zhao Zhihong Zhu Behrooz Z Alizadeh Najaf Amin Andrew Bakshi Sebastian E Baumeister Ginevra Biino Klaus Bønnelykke Patricia A Boyle Harry Campbell Francesco P Cappuccio Gail Davies Jan-Emmanuel De Neve Panos Deloukas Ilja Demuth Jun Ding Peter Eibich Lewin Eisele Niina Eklund David M Evans Jessica D Faul Mary F Feitosa Andreas J Forstner Ilaria Gandin Bjarni Gunnarsson Bjarni V Halldórsson Tamara B Harris Andrew C Heath Lynne J Hocking Elizabeth G Holliday Georg Homuth Michael A Horan Jouke-Jan Hottenga Philip L de Jager Peter K Joshi Astanand Jugessur Marika A Kaakinen Mika Kähönen Stavroula Kanoni Liisa Keltigangas-Järvinen Lambertus A L M Kiemeney Ivana Kolcic Seppo Koskinen Aldi T Kraja Martin Kroh Zoltan Kutalik Antti Latvala Lenore J Launer Maël P Lebreton Douglas F Levinson Paul Lichtenstein Peter Lichtner David C M Liewald Anu Loukola Pamela A Madden Reedik Mägi Tomi Mäki-Opas Riccardo E Marioni Pedro Marques-Vidal Gerardus A Meddens George McMahon Christa Meisinger Thomas Meitinger Yusplitri Milaneschi Lili Milani Grant W Montgomery Ronny Myhre Christopher P Nelson Dale R Nyholt William E R Ollier Aarno Palotie Lavinia Paternoster Nancy L Pedersen Katja E Petrovic David J Porteous Katri Räikkönen Susan M Ring Antonietta Robino Olga Rostapshova Igor Rudan Aldo Rustichini Veikko Salomaa Alan R Sanders Antti-Pekka Sarin Helena Schmidt Rodney J Scott Blair H Smith Jennifer A Smith Jan A Staessen Elisabeth Steinhagen-Thiessen Konstantin Strauch Antonio Terracciano Martin D Tobin Sheila Ulivi Simona Vaccargiu Lydia Quaye Frank J A van Rooij Cristina Venturini Anna A E Vinkhuyzen Uwe Völker Henry Völzke Judith M Vonk Diego Vozzi Johannes Waage Erin B Ware Gonneke Willemsen John R Attia David A Bennett Klaus Berger Lars Bertram Hans Bisgaard Dorret I Boomsma Ingrid B Borecki Ute Bültmann Christopher F Chabris Francesco Cucca Daniele Cusi Ian J Deary George V Dedoussis Cornelia M van Duijn Johan G Eriksson Barbara Franke Lude Franke Paolo Gasparini Pablo V Gejman Christian Gieger Hans-Jörgen Grabe Jacob Gratten Patrick J F Groenen Vilmundur Gudnason Pim van der Harst Caroline Hayward David A Hinds Wolfgang Hoffmann Elina Hyppönen William G Iacono Bo Jacobsson Marjo-Riitta Järvelin Karl-Heinz Jöckel Jaakko Kaprio Sharon L R Kardia Terho Lehtimäki Steven F Lehrer Patrik K E Magnusson Nicholas G Martin Matt McGue Andres Metspalu Neil Pendleton Brenda W J H Penninx Markus Perola Nicola Pirastu Mario Pirastu Ozren Polasek Danielle Posthuma Christine Power Michael A Province Nilesh J Samani David Schlessinger Reinhold Schmidt Thorkild I A Sørensen Tim D Spector Kari Stefansson Unnur Thorsteinsdottir A Roy Thurik Nicholas J Timpson Henning Tiemeier Joyce Y Tung André G Uitterlinden Veronique Vitart Peter Vollenweider David R Weir James F Wilson Alan F Wright Dalton C Conley Robert F Krueger George Davey Smith Albert Hofman David I Laibson Sarah E Medland Michelle N Meyer Jian Yang Magnus Johannesson Peter M Visscher Tõnu Esko Philipp D Koellinger David Cesarini Daniel J Benjamin

Nature 2016 05 11;533(7604):539-42. Epub 2016 May 11.

Center for Economic and Social Research, University of Southern California, Los Angeles, California 90089-3332, USA.

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http://dx.doi.org/10.1038/nature17671DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4883595PMC
May 2016

New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk.

Authors:
Yingchang Lu Felix R Day Stefan Gustafsson Martin L Buchkovich Jianbo Na Veronique Bataille Diana L Cousminer Zari Dastani Alexander W Drong Tõnu Esko David M Evans Mario Falchi Mary F Feitosa Teresa Ferreira Åsa K Hedman Robin Haring Pirro G Hysi Mark M Iles Anne E Justice Stavroula Kanoni Vasiliki Lagou Rui Li Xin Li Adam Locke Chen Lu Reedik Mägi John R B Perry Tune H Pers Qibin Qi Marianna Sanna Ellen M Schmidt William R Scott Dmitry Shungin Alexander Teumer Anna A E Vinkhuyzen Ryan W Walker Harm-Jan Westra Mingfeng Zhang Weihua Zhang Jing Hua Zhao Zhihong Zhu Uzma Afzal Tarunveer Singh Ahluwalia Stephan J L Bakker Claire Bellis Amélie Bonnefond Katja Borodulin Aron S Buchman Tommy Cederholm Audrey C Choh Hyung Jin Choi Joanne E Curran Lisette C P G M de Groot Philip L De Jager Rosalie A M Dhonukshe-Rutten Anke W Enneman Elodie Eury Daniel S Evans Tom Forsen Nele Friedrich Frédéric Fumeron Melissa E Garcia Simone Gärtner Bok-Ghee Han Aki S Havulinna Caroline Hayward Dena Hernandez Hans Hillege Till Ittermann Jack W Kent Ivana Kolcic Tiina Laatikainen Jari Lahti Irene Mateo Leach Christine G Lee Jong-Young Lee Tian Liu Youfang Liu Stéphane Lobbens Marie Loh Leo-Pekka Lyytikäinen Carolina Medina-Gomez Karl Michaëlsson Mike A Nalls Carrie M Nielson Laticia Oozageer Laura Pascoe Lavinia Paternoster Ozren Polašek Samuli Ripatti Mark A Sarzynski Chan Soo Shin Nina Smolej Narančić Dominik Spira Priya Srikanth Elisabeth Steinhagen-Thiessen Yun Ju Sung Karin M A Swart Leena Taittonen Toshiko Tanaka Emmi Tikkanen Nathalie van der Velde Natasja M van Schoor Niek Verweij Alan F Wright Lei Yu Joseph M Zmuda Niina Eklund Terrence Forrester Niels Grarup Anne U Jackson Kati Kristiansson Teemu Kuulasmaa Johanna Kuusisto Peter Lichtner Jian'an Luan Anubha Mahajan Satu Männistö Cameron D Palmer Janina S Ried Robert A Scott Alena Stancáková Peter J Wagner Ayse Demirkan Angela Döring Vilmundur Gudnason Douglas P Kiel Brigitte Kühnel Massimo Mangino Barbara Mcknight Cristina Menni Jeffrey R O'Connell Ben A Oostra Alan R Shuldiner Kijoung Song Liesbeth Vandenput Cornelia M van Duijn Peter Vollenweider Charles C White Michael Boehnke Yvonne Boettcher Richard S Cooper Nita G Forouhi Christian Gieger Harald Grallert Aroon Hingorani Torben Jørgensen Pekka Jousilahti Mika Kivimaki Meena Kumari Markku Laakso Claudia Langenberg Allan Linneberg Amy Luke Colin A Mckenzie Aarno Palotie Oluf Pedersen Annette Peters Konstantin Strauch Bamidele O Tayo Nicholas J Wareham David A Bennett Lars Bertram John Blangero Matthias Blüher Claude Bouchard Harry Campbell Nam H Cho Steven R Cummings Stefan A Czerwinski Ilja Demuth Rahel Eckardt Johan G Eriksson Luigi Ferrucci Oscar H Franco Philippe Froguel Ron T Gansevoort Torben Hansen Tamara B Harris Nicholas Hastie Markku Heliövaara Albert Hofman Joanne M Jordan Antti Jula Mika Kähönen Eero Kajantie Paul B Knekt Seppo Koskinen Peter Kovacs Terho Lehtimäki Lars Lind Yongmei Liu Eric S Orwoll Clive Osmond Markus Perola Louis Pérusse Olli T Raitakari Tuomo Rankinen D C Rao Treva K Rice Fernando Rivadeneira Igor Rudan Veikko Salomaa Thorkild I A Sørensen Michael Stumvoll Anke Tönjes Bradford Towne Gregory J Tranah Angelo Tremblay André G Uitterlinden Pim van der Harst Erkki Vartiainen Jorma S Viikari Veronique Vitart Marie-Claude Vohl Henry Völzke Mark Walker Henri Wallaschofski Sarah Wild James F Wilson Loïc Yengo D Timothy Bishop Ingrid B Borecki John C Chambers L Adrienne Cupples Abbas Dehghan Panos Deloukas Ghazaleh Fatemifar Caroline Fox Terrence S Furey Lude Franke Jiali Han David J Hunter Juha Karjalainen Fredrik Karpe Robert C Kaplan Jaspal S Kooner Mark I McCarthy Joanne M Murabito Andrew P Morris Julia A N Bishop Kari E North Claes Ohlsson Ken K Ong Inga Prokopenko J Brent Richards Eric E Schadt Tim D Spector Elisabeth Widén Cristen J Willer Jian Yang Erik Ingelsson Karen L Mohlke Joel N Hirschhorn John Andrew Pospisilik M Carola Zillikens Cecilia Lindgren Tuomas Oskari Kilpeläinen Ruth J F Loos

Nat Commun 2016 Feb 1;7:10495. Epub 2016 Feb 1.

The Charles Bronfman Institute for Personalized Medicine, The Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.

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http://dx.doi.org/10.1038/ncomms10495DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4740398PMC
February 2016

The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study.

Authors:
Thomas W Winkler Anne E Justice Mariaelisa Graff Llilda Barata Mary F Feitosa Su Chu Jacek Czajkowski Tõnu Esko Tove Fall Tuomas O Kilpeläinen Yingchang Lu Reedik Mägi Evelin Mihailov Tune H Pers Sina Rüeger Alexander Teumer Georg B Ehret Teresa Ferreira Nancy L Heard-Costa Juha Karjalainen Vasiliki Lagou Anubha Mahajan Michael D Neinast Inga Prokopenko Jeannette Simino Tanya M Teslovich Rick Jansen Harm-Jan Westra Charles C White Devin Absher Tarunveer S Ahluwalia Shafqat Ahmad Eva Albrecht Alexessander Couto Alves Jennifer L Bragg-Gresham Anton J M de Craen Joshua C Bis Amélie Bonnefond Gabrielle Boucher Gemma Cadby Yu-Ching Cheng Charleston W K Chiang Graciela Delgado Ayse Demirkan Nicole Dueker Niina Eklund Gudny Eiriksdottir Joel Eriksson Bjarke Feenstra Krista Fischer Francesca Frau Tessel E Galesloot Frank Geller Anuj Goel Mathias Gorski Tanja B Grammer Stefan Gustafsson Saskia Haitjema Jouke-Jan Hottenga Jennifer E Huffman Anne U Jackson Kevin B Jacobs Åsa Johansson Marika Kaakinen Marcus E Kleber Jari Lahti Irene Mateo Leach Benjamin Lehne Youfang Liu Ken Sin Lo Mattias Lorentzon Jian'an Luan Pamela A F Madden Massimo Mangino Barbara McKnight Carolina Medina-Gomez Keri L Monda May E Montasser Gabriele Müller Martina Müller-Nurasyid Ilja M Nolte Kalliope Panoutsopoulou Laura Pascoe Lavinia Paternoster Nigel W Rayner Frida Renström Federica Rizzi Lynda M Rose Kathy A Ryan Perttu Salo Serena Sanna Hubert Scharnagl Jianxin Shi Albert Vernon Smith Lorraine Southam Alena Stančáková Valgerdur Steinthorsdottir Rona J Strawbridge Yun Ju Sung Ioanna Tachmazidou Toshiko Tanaka Gudmar Thorleifsson Stella Trompet Natalia Pervjakova Jonathan P Tyrer Liesbeth Vandenput Sander W van der Laan Nathalie van der Velde Jessica van Setten Jana V van Vliet-Ostaptchouk Niek Verweij Efthymia Vlachopoulou Lindsay L Waite Sophie R Wang Zhaoming Wang Sarah H Wild Christina Willenborg James F Wilson Andrew Wong Jian Yang Loïc Yengo Laura M Yerges-Armstrong Lei Yu Weihua Zhang Jing Hua Zhao Ehm A Andersson Stephan J L Bakker Damiano Baldassarre Karina Banasik Matteo Barcella Cristina Barlassina Claire Bellis Paola Benaglio John Blangero Matthias Blüher Fabrice Bonnet Lori L Bonnycastle Heather A Boyd Marcel Bruinenberg Aron S Buchman Harry Campbell Yii-Der Ida Chen Peter S Chines Simone Claudi-Boehm John Cole Francis S Collins Eco J C de Geus Lisette C P G M de Groot Maria Dimitriou Jubao Duan Stefan Enroth Elodie Eury Aliki-Eleni Farmaki Nita G Forouhi Nele Friedrich Pablo V Gejman Bruna Gigante Nicola Glorioso Alan S Go Omri Gottesman Jürgen Gräßler Harald Grallert Niels Grarup Yu-Mei Gu Linda Broer Annelies C Ham Torben Hansen Tamara B Harris Catharina A Hartman Maija Hassinen Nicholas Hastie Andrew T Hattersley Andrew C Heath Anjali K Henders Dena Hernandez Hans Hillege Oddgeir Holmen Kees G Hovingh Jennie Hui Lise L Husemoen Nina Hutri-Kähönen Pirro G Hysi Thomas Illig Philip L De Jager Shapour Jalilzadeh Torben Jørgensen J Wouter Jukema Markus Juonala Stavroula Kanoni Maria Karaleftheri Kay Tee Khaw Leena Kinnunen Steven J Kittner Wolfgang Koenig Ivana Kolcic Peter Kovacs Nikolaj T Krarup Wolfgang Kratzer Janine Krüger Diana Kuh Meena Kumari Theodosios Kyriakou Claudia Langenberg Lars Lannfelt Chiara Lanzani Vaneet Lotay Lenore J Launer Karin Leander Jaana Lindström Allan Linneberg Yan-Ping Liu Stéphane Lobbens Robert Luben Valeriya Lyssenko Satu Männistö Patrik K Magnusson Wendy L McArdle Cristina Menni Sigrun Merger Lili Milani Grant W Montgomery Andrew P Morris Narisu Narisu Mari Nelis Ken K Ong Aarno Palotie Louis Pérusse Irene Pichler Maria G Pilia Anneli Pouta Myriam Rheinberger Rasmus Ribel-Madsen Marcus Richards Kenneth M Rice Treva K Rice Carlo Rivolta Veikko Salomaa Alan R Sanders Mark A Sarzynski Salome Scholtens Robert A Scott William R Scott Sylvain Sebert Sebanti Sengupta Bengt Sennblad Thomas Seufferlein Angela Silveira P Eline Slagboom Jan H Smit Thomas H Sparsø Kathleen Stirrups Ronald P Stolk Heather M Stringham Morris A Swertz Amy J Swift Ann-Christine Syvänen Sian-Tsung Tan Barbara Thorand Anke Tönjes Angelo Tremblay Emmanouil Tsafantakis Peter J van der Most Uwe Völker Marie-Claude Vohl Judith M Vonk Melanie Waldenberger Ryan W Walker Roman Wennauer Elisabeth Widén Gonneke Willemsen Tom Wilsgaard Alan F Wright M Carola Zillikens Suzanne C van Dijk Natasja M van Schoor Folkert W Asselbergs Paul I W de Bakker Jacques S Beckmann John Beilby David A Bennett Richard N Bergman Sven Bergmann Carsten A Böger Bernhard O Boehm Eric Boerwinkle Dorret I Boomsma Stefan R Bornstein Erwin P Bottinger Claude Bouchard John C Chambers Stephen J Chanock Daniel I Chasman Francesco Cucca Daniele Cusi George Dedoussis Jeanette Erdmann Johan G Eriksson Denis A Evans Ulf de Faire Martin Farrall Luigi Ferrucci Ian Ford Lude Franke Paul W Franks Philippe Froguel Ron T Gansevoort Christian Gieger Henrik Grönberg Vilmundur Gudnason Ulf Gyllensten Per Hall Anders Hamsten Pim van der Harst Caroline Hayward Markku Heliövaara Christian Hengstenberg Andrew A Hicks Aroon Hingorani Albert Hofman Frank Hu Heikki V Huikuri Kristian Hveem Alan L James Joanne M Jordan Antti Jula Mika Kähönen Eero Kajantie Sekar Kathiresan Lambertus A L M Kiemeney Mika Kivimaki Paul B Knekt Heikki A Koistinen Jaspal S Kooner Seppo Koskinen Johanna Kuusisto Winfried Maerz Nicholas G Martin Markku Laakso Timo A Lakka Terho Lehtimäki Guillaume Lettre Douglas F Levinson Lars Lind Marja-Liisa Lokki Pekka Mäntyselkä Mads Melbye Andres Metspalu Braxton D Mitchell Frans L Moll Jeffrey C Murray Arthur W Musk Markku S Nieminen Inger Njølstad Claes Ohlsson Albertine J Oldehinkel Ben A Oostra Lyle J Palmer James S Pankow Gerard Pasterkamp Nancy L Pedersen Oluf Pedersen Brenda W Penninx Markus Perola Annette Peters Ozren Polašek Peter P Pramstaller Bruce M Psaty Lu Qi Thomas Quertermous Olli T Raitakari Tuomo Rankinen Rainer Rauramaa Paul M Ridker John D Rioux Fernando Rivadeneira Jerome I Rotter Igor Rudan Hester M den Ruijter Juha Saltevo Naveed Sattar Heribert Schunkert Peter E H Schwarz Alan R Shuldiner Juha Sinisalo Harold Snieder Thorkild I A Sørensen Tim D Spector Jan A Staessen Bandinelli Stefania Unnur Thorsteinsdottir Michael Stumvoll Jean-Claude Tardif Elena Tremoli Jaakko Tuomilehto André G Uitterlinden Matti Uusitupa André L M Verbeek Sita H Vermeulen Jorma S Viikari Veronique Vitart Henry Völzke Peter Vollenweider Gérard Waeber Mark Walker Henri Wallaschofski Nicholas J Wareham Hugh Watkins Eleftheria Zeggini Aravinda Chakravarti Deborah J Clegg L Adrienne Cupples Penny Gordon-Larsen Cashell E Jaquish D C Rao Goncalo R Abecasis Themistocles L Assimes Inês Barroso Sonja I Berndt Michael Boehnke Panos Deloukas Caroline S Fox Leif C Groop David J Hunter Erik Ingelsson Robert C Kaplan Mark I McCarthy Karen L Mohlke Jeffrey R O'Connell David Schlessinger David P Strachan Kari Stefansson Cornelia M van Duijn Joel N Hirschhorn Cecilia M Lindgren Iris M Heid Kari E North Ingrid B Borecki Zoltán Kutalik Ruth J F Loos

PLoS Genet 2015 Oct 1;11(10):e1005378. Epub 2015 Oct 1.

MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom; The Charles Bronfman Institute for Personalized Medicine, The Icahn School of Medicine at Mount Sinai, New York, New York, United States of America; The Department of Preventive Medicine, The Icahn School of Medicine at Mount Sinai, New York, New York, United States of America; The Genetics of Obesity and Related Metabolic Traits Program, The Icahn School of Medicine at Mount Sinai, New York, New York, United States of America; The Mindich Child Health and Development Institute, The Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4591371PMC
October 2015

An integrative systems genetics approach reveals potential causal genes and pathways related to obesity.

Authors:
Lisette J A Kogelman Daria V Zhernakova Harm-Jan Westra Susanna Cirera Merete Fredholm Lude Franke Haja N Kadarmideen

Genome Med 2015 Oct 20;7:105. Epub 2015 Oct 20.

Department of Veterinary Clinical and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Grønnegårdsvej 7, 1870, Frederiksberg C, Denmark.

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http://dx.doi.org/10.1186/s13073-015-0229-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4617184PMC
October 2015

The transcriptional landscape of age in human peripheral blood.

Authors:
Marjolein J Peters Roby Joehanes Luke C Pilling Claudia Schurmann Karen N Conneely Joseph Powell Eva Reinmaa George L Sutphin Alexandra Zhernakova Katharina Schramm Yana A Wilson Sayuko Kobes Taru Tukiainen Yolande F Ramos Harald H H Göring Myriam Fornage Yongmei Liu Sina A Gharib Barbara E Stranger Philip L De Jager Abraham Aviv Daniel Levy Joanne M Murabito Peter J Munson Tianxiao Huan Albert Hofman André G Uitterlinden Fernando Rivadeneira Jeroen van Rooij Lisette Stolk Linda Broer Michael M P J Verbiest Mila Jhamai Pascal Arp Andres Metspalu Liina Tserel Lili Milani Nilesh J Samani Pärt Peterson Silva Kasela Veryan Codd Annette Peters Cavin K Ward-Caviness Christian Herder Melanie Waldenberger Michael Roden Paula Singmann Sonja Zeilinger Thomas Illig Georg Homuth Hans-Jörgen Grabe Henry Völzke Leif Steil Thomas Kocher Anna Murray David Melzer Hanieh Yaghootkar Stefania Bandinelli Eric K Moses Jack W Kent Joanne E Curran Matthew P Johnson Sarah Williams-Blangero Harm-Jan Westra Allan F McRae Jennifer A Smith Sharon L R Kardia Iiris Hovatta Markus Perola Samuli Ripatti Veikko Salomaa Anjali K Henders Nicholas G Martin Alicia K Smith Divya Mehta Elisabeth B Binder K Maria Nylocks Elizabeth M Kennedy Torsten Klengel Jingzhong Ding Astrid M Suchy-Dicey Daniel A Enquobahrie Jennifer Brody Jerome I Rotter Yii-Der I Chen Jeanine Houwing-Duistermaat Margreet Kloppenburg P Eline Slagboom Quinta Helmer Wouter den Hollander Shannon Bean Towfique Raj Noman Bakhshi Qiao Ping Wang Lisa J Oyston Bruce M Psaty Russell P Tracy Grant W Montgomery Stephen T Turner John Blangero Ingrid Meulenbelt Kerry J Ressler Jian Yang Lude Franke Johannes Kettunen Peter M Visscher G Gregory Neely Ron Korstanje Robert L Hanson Holger Prokisch Luigi Ferrucci Tonu Esko Alexander Teumer Joyce B J van Meurs Andrew D Johnson

Nat Commun 2015 Oct 22;6:8570. Epub 2015 Oct 22.

The National Heart, Lung, and Blood Institute's and Boston University's Framingham Heart Study, Framingham, Massachusetts 01702, USA.

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http://dx.doi.org/10.1038/ncomms9570DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4639797PMC
October 2015

Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations.

Authors:
Jimmy Z Liu Suzanne van Sommeren Hailiang Huang Siew C Ng Rudi Alberts Atsushi Takahashi Stephan Ripke James C Lee Luke Jostins Tejas Shah Shifteh Abedian Jae Hee Cheon Judy Cho Naser E Dayani Lude Franke Yuta Fuyuno Ailsa Hart Ramesh C Juyal Garima Juyal Won Ho Kim Andrew P Morris Hossein Poustchi William G Newman Vandana Midha Timothy R Orchard Homayon Vahedi Ajit Sood Joseph Y Sung Reza Malekzadeh Harm-Jan Westra Keiko Yamazaki Suk-Kyun Yang Jeffrey C Barrett Behrooz Z Alizadeh Miles Parkes Thelma Bk Mark J Daly Michiaki Kubo Carl A Anderson Rinse K Weersma

Nat Genet 2015 Sep 20;47(9):979-986. Epub 2015 Jul 20.

Department of Gastroenterology and Hepatology, University Medical Center Groningen, Groningen, The Netherlands.

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http://dx.doi.org/10.1038/ng.3359DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4881818PMC
September 2015

Disentangling the Effects of Colocalizing Genomic Annotations to Functionally Prioritize Non-coding Variants within Complex-Trait Loci.

Authors:
Gosia Trynka Harm-Jan Westra Kamil Slowikowski Xinli Hu Han Xu Barbara E Stranger Robert J Klein Buhm Han Soumya Raychaudhuri

Am J Hum Genet 2015 Jul;97(1):139-52

Divisions of Genetics and Rheumatology, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02446, USA; Partners Center for Personalized Genetic Medicine, Boston, MA 02446, USA; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Institute of Inflammation and Repair, University of Manchester, Manchester M13 9PT, UK. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2015.05.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4572568PMC
July 2015

A functional brain-derived neurotrophic factor (BDNF) gene variant increases the risk of moderate-to-severe allergic rhinitis.

Authors:
Peng Jin Anand Kumar Andiappan Jia Min Quek Bernett Lee Bijin Au Yang Yie Sio Astrid Irwanto Claudia Schurmann Hans Jörgen Grabe Bani Kaur Suri Sri Anusha Matta Harm-Jan Westra Lude Franke Tonu Esko Liangdan Sun Xuejun Zhang Hong Liu Furen Zhang Anis Larbi Xin Xu Michael Poidinger Jianjun Liu Fook Tim Chew Olaf Rotzschke Li Shi De Yun Wang

J Allergy Clin Immunol 2015 Jun 30;135(6):1486-93.e8. Epub 2015 Jan 30.

Department of Otolaryngology, Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, Singapore. Electronic address:

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June 2015

The impact of low-frequency and rare variants on lipid levels.

Authors:
Ida Surakka Momoko Horikoshi Reedik Mägi Antti-Pekka Sarin Anubha Mahajan Vasiliki Lagou Letizia Marullo Teresa Ferreira Benjamin Miraglio Sanna Timonen Johannes Kettunen Matti Pirinen Juha Karjalainen Gudmar Thorleifsson Sara Hägg Jouke-Jan Hottenga Aaron Isaacs Claes Ladenvall Marian Beekman Tõnu Esko Janina S Ried Christopher P Nelson Christina Willenborg Stefan Gustafsson Harm-Jan Westra Matthew Blades Anton J M de Craen Eco J de Geus Joris Deelen Harald Grallert Anders Hamsten Aki S Havulinna Christian Hengstenberg Jeanine J Houwing-Duistermaat Elina Hyppönen Lennart C Karssen Terho Lehtimäki Valeriya Lyssenko Patrik K E Magnusson Evelin Mihailov Martina Müller-Nurasyid John-Patrick Mpindi Nancy L Pedersen Brenda W J H Penninx Markus Perola Tune H Pers Annette Peters Johan Rung Johannes H Smit Valgerdur Steinthorsdottir Martin D Tobin Natalia Tsernikova Elisabeth M van Leeuwen Jorma S Viikari Sara M Willems Gonneke Willemsen Heribert Schunkert Jeanette Erdmann Nilesh J Samani Jaakko Kaprio Lars Lind Christian Gieger Andres Metspalu P Eline Slagboom Leif Groop Cornelia M van Duijn Johan G Eriksson Antti Jula Veikko Salomaa Dorret I Boomsma Christine Power Olli T Raitakari Erik Ingelsson Marjo-Riitta Järvelin Unnur Thorsteinsdottir Lude Franke Elina Ikonen Olli Kallioniemi Vilja Pietiäinen Cecilia M Lindgren Kari Stefansson Aarno Palotie Mark I McCarthy Andrew P Morris Inga Prokopenko Samuli Ripatti

Nat Genet 2015 Jun 11;47(6):589-97. Epub 2015 May 11.

1] Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland. [2] Department of Public Health, University of Helsinki, Helsinki, Finland. [3] Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK.

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http://dx.doi.org/10.1038/ng.3300DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4757735PMC
June 2015

Genome-wide association study identifies novel genetic variants contributing to variation in blood metabolite levels.

Authors:
Harmen H M Draisma René Pool Michael Kobl Rick Jansen Ann-Kristin Petersen Anika A M Vaarhorst Idil Yet Toomas Haller Ayşe Demirkan Tõnu Esko Gu Zhu Stefan Böhringer Marian Beekman Jan Bert van Klinken Werner Römisch-Margl Cornelia Prehn Jerzy Adamski Anton J M de Craen Elisabeth M van Leeuwen Najaf Amin Harish Dharuri Harm-Jan Westra Lude Franke Eco J C de Geus Jouke Jan Hottenga Gonneke Willemsen Anjali K Henders Grant W Montgomery Dale R Nyholt John B Whitfield Brenda W Penninx Tim D Spector Andres Metspalu P Eline Slagboom Ko Willems van Dijk Peter A C 't Hoen Konstantin Strauch Nicholas G Martin Gert-Jan B van Ommen Thomas Illig Jordana T Bell Massimo Mangino Karsten Suhre Mark I McCarthy Christian Gieger Aaron Isaacs Cornelia M van Duijn Dorret I Boomsma

Nat Commun 2015 Jun 12;6:7208. Epub 2015 Jun 12.

Department of Biological Psychology, VU University Amsterdam, van der Boechorststraat 1, Amsterdam 1081 BT, The Netherlands.

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http://dx.doi.org/10.1038/ncomms8208DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4745136PMC
June 2015

Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption.

Authors:
Marilyn C Cornelis Enda M Byrne Tõnu Esko Michael A Nalls Andrea Ganna Nina Paynter Keri L Monda Najaf Amin Krista Fischer Frida Renstrom Julius S Ngwa Ville Huikari Alana Cavadino Ilja M Nolte Alexander Teumer Kai Yu Pedro Marques-Vidal Rajesh Rawal Ani Manichaikul Mary K Wojczynski Jacqueline M Vink Jing Hua Zhao George Burlutsky Jari Lahti Vera Mikkilä Rozenn N Lemaitre Joel Eriksson Solomon K Musani Toshiko Tanaka Frank Geller Jian'an Luan Jennie Hui Reedik Mägi Maria Dimitriou Melissa E Garcia Weang-Kee Ho Margaret J Wright Lynda M Rose Patrik Ke Magnusson Nancy L Pedersen David Couper Ben A Oostra Albert Hofman Mohammad Arfan Ikram Henning W Tiemeier Andre G Uitterlinden Frank Ja van Rooij Inês Barroso Ingegerd Johansson Luting Xue Marika Kaakinen Lili Milani Chris Power Harold Snieder Ronald P Stolk Sebastian E Baumeister Reiner Biffar Fangyi Gu François Bastardot Zoltán Kutalik David R Jacobs Nita G Forouhi Evelin Mihailov Lars Lind Cecilia Lindgren Karl Michaëlsson Andrew Morris Majken Jensen Kay-Tee Khaw Robert N Luben Jie Jin Wang Satu Männistö Mia-Maria Perälä Mika Kähönen Terho Lehtimäki Jorma Viikari Dariush Mozaffarian Kenneth Mukamal Bruce M Psaty Angela Döring Andrew C Heath Grant W Montgomery Norbert Dahmen Teresa Carithers Katherine L Tucker Luigi Ferrucci Heather A Boyd Mads Melbye Jorien L Treur Dan Mellström Jouke Jan Hottenga Inga Prokopenko Anke Tönjes Panos Deloukas Stavroula Kanoni Mattias Lorentzon Denise K Houston Yongmei Liu John Danesh Asif Rasheed Marc A Mason Alan B Zonderman Lude Franke Bruce S Kristal Juha Karjalainen Danielle R Reed Harm-Jan Westra Michele K Evans Danish Saleheen Tamara B Harris George Dedoussis Gary Curhan Michael Stumvoll John Beilby Louis R Pasquale Bjarke Feenstra Stefania Bandinelli Jose M Ordovas Andrew T Chan Ulrike Peters Claes Ohlsson Christian Gieger Nicholas G Martin Melanie Waldenberger David S Siscovick Olli Raitakari Johan G Eriksson Paul Mitchell David J Hunter Peter Kraft Eric B Rimm Dorret I Boomsma Ingrid B Borecki Ruth Jf Loos Nicholas J Wareham Peter Vollenweider Neil Caporaso Hans Jörgen Grabe Marian L Neuhouser Bruce Hr Wolffenbuttel Frank B Hu Elina Hyppönen Marjo-Riitta Järvelin L Adrienne Cupples Paul W Franks Paul M Ridker Cornelia M van Duijn Gerardo Heiss Andres Metspalu Kari E North Erik Ingelsson Jennifer A Nettleton Rob M van Dam Daniel I Chasman

Mol Psychiatry 2015 May 7;20(5):647-656. Epub 2014 Oct 7.

Division of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

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https://handls.nih.gov/pubs/2015-Coffee-MolPsychiatry-20-647
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http://dx.doi.org/10.1038/mp.2014.107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4388784PMC
May 2015

Cell Specific eQTL Analysis without Sorting Cells.

Authors:
Harm-Jan Westra Danny Arends Tõnu Esko Marjolein J Peters Claudia Schurmann Katharina Schramm Johannes Kettunen Hanieh Yaghootkar Benjamin P Fairfax Anand Kumar Andiappan Yang Li Jingyuan Fu Juha Karjalainen Mathieu Platteel Marijn Visschedijk Rinse K Weersma Silva Kasela Lili Milani Liina Tserel Pärt Peterson Eva Reinmaa Albert Hofman André G Uitterlinden Fernando Rivadeneira Georg Homuth Astrid Petersmann Roberto Lorbeer Holger Prokisch Thomas Meitinger Christian Herder Michael Roden Harald Grallert Samuli Ripatti Markus Perola Andrew R Wood David Melzer Luigi Ferrucci Andrew B Singleton Dena G Hernandez Julian C Knight Rossella Melchiotti Bernett Lee Michael Poidinger Francesca Zolezzi Anis Larbi De Yun Wang Leonard H van den Berg Jan H Veldink Olaf Rotzschke Seiko Makino Veikko Salomaa Konstantin Strauch Uwe Völker Joyce B J van Meurs Andres Metspalu Cisca Wijmenga Ritsert C Jansen Lude Franke

PLoS Genet 2015 May 8;11(5):e1005223. Epub 2015 May 8.

University of Groningen, University Medical Center Groningen, Department of Genetics, Groningen, The Netherlands.

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http://dx.doi.org/10.1371/journal.pgen.1005223DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4425538PMC
May 2015

Corrigendum: Novel loci affecting iron homeostasis and their effects in individuals at risk for hemochromatosis.

Authors:
Beben Benyamin Tonu Esko Janina S Ried Aparna Radhakrishnan Sita H Vermeulen Michela Traglia Martin Gögele Denise Anderson Linda Broer Clara Podmore Jiańan Luan Zoltan Kutalik Serena Sanna Peter van der Meer Toshiko Tanaka Fudi Wang Harm-Jan Westra Lude Franke Evelin Mihailov Lili Milani Jonas Hälldin Juliane Winkelmann Thomas Meitinger Joachim Thiery Annette Peters Melanie Waldenberger Augusto Rendon Jennifer Jolley Jennifer Sambrook Lambertus A Kiemeney Fred C Sweep Cinzia F Sala Christine Schwienbacher Irene Pichler Jennie Hui Ayse Demirkan Aaron Isaacs Najaf Amin Maristella Steri Gérard Waeber Niek Verweij Joseph E Powell Dale R Nyholt Andrew C Heath Pamela A F Madden Peter M Visscher Margaret J Wright Grant W Montgomery Nicholas G Martin Dena Hernandez Stefania Bandinelli Pim van der Harst Manuela Uda Peter Vollenweider Robert A Scott Claudia Langenberg Nicholas J Wareham Cornelia van Duijn John Beilby Peter P Pramstaller Andrew A Hicks Willem H Ouwehand Konrad Oexle Christian Gieger Andres Metspalu Clara Camaschella Daniela Toniolo Dorine W Swinkels John B Whitfield

Nat Commun 2015 Mar 30;6:6542. Epub 2015 Mar 30.

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March 2015

Genetic variants of inducible costimulator are associated with allergic asthma susceptibility.

Authors:
Anand Kumar Andiappan Sriram Narayanan Rachel A Myers Bernett Lee Maartje A Nieuwenhuis Alessandra Nardin Choon-Sik Park Hyoung Doo Shin Jeong-Hyun Kim Harm-Jan Westra Lude Franke Tonu Esko Andres Metspalu Yik-Ying Teo Seang Mei Saw Chiea Chuen Khor Jianjun Liu Gerard H Koppelman Dirkje S Postma Michael Poidinger John E Connolly De Yun Wang Olaf Rotzschke Maria A Curotto de Lafaille Fook Tim Chew

J Allergy Clin Immunol 2015 Feb 7;135(2):556-8. Epub 2014 Aug 7.

Department of Biological Sciences, National University of Singapore, Singapore.

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February 2015

Gene expression analysis identifies global gene dosage sensitivity in cancer.

Authors:
Rudolf S N Fehrmann Juha M Karjalainen Małgorzata Krajewska Harm-Jan Westra David Maloney Anton Simeonov Tune H Pers Joel N Hirschhorn Ritsert C Jansen Erik A Schultes Herman H H B M van Haagen Elisabeth G E de Vries Gerard J te Meerman Cisca Wijmenga Marcel A T M van Vugt Lude Franke

Nat Genet 2015 Feb 12;47(2):115-25. Epub 2015 Jan 12.

Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.

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February 2015

New genetic loci link adipose and insulin biology to body fat distribution.

Authors:
Dmitry Shungin Thomas W Winkler Damien C Croteau-Chonka Teresa Ferreira Adam E Locke Reedik Mägi Rona J Strawbridge Tune H Pers Krista Fischer Anne E Justice Tsegaselassie Workalemahu Joseph M W Wu Martin L Buchkovich Nancy L Heard-Costa Tamara S Roman Alexander W Drong Ci Song Stefan Gustafsson Felix R Day Tonu Esko Tove Fall Zoltán Kutalik Jian'an Luan Joshua C Randall André Scherag Sailaja Vedantam Andrew R Wood Jin Chen Rudolf Fehrmann Juha Karjalainen Bratati Kahali Ching-Ti Liu Ellen M Schmidt Devin Absher Najaf Amin Denise Anderson Marian Beekman Jennifer L Bragg-Gresham Steven Buyske Ayse Demirkan Georg B Ehret Mary F Feitosa Anuj Goel Anne U Jackson Toby Johnson Marcus E Kleber Kati Kristiansson Massimo Mangino Irene Mateo Leach Carolina Medina-Gomez Cameron D Palmer Dorota Pasko Sonali Pechlivanis Marjolein J Peters Inga Prokopenko Alena Stančáková Yun Ju Sung Toshiko Tanaka Alexander Teumer Jana V Van Vliet-Ostaptchouk Loïc Yengo Weihua Zhang Eva Albrecht Johan Ärnlöv Gillian M Arscott Stefania Bandinelli Amy Barrett Claire Bellis Amanda J Bennett Christian Berne Matthias Blüher Stefan Böhringer Fabrice Bonnet Yvonne Böttcher Marcel Bruinenberg Delia B Carba Ida H Caspersen Robert Clarke E Warwick Daw Joris Deelen Ewa Deelman Graciela Delgado Alex Sf Doney Niina Eklund Michael R Erdos Karol Estrada Elodie Eury Nele Friedrich Melissa E Garcia Vilmantas Giedraitis Bruna Gigante Alan S Go Alain Golay Harald Grallert Tanja B Grammer Jürgen Gräßler Jagvir Grewal Christopher J Groves Toomas Haller Goran Hallmans Catharina A Hartman Maija Hassinen Caroline Hayward Kauko Heikkilä Karl-Heinz Herzig Quinta Helmer Hans L Hillege Oddgeir Holmen Steven C Hunt Aaron Isaacs Till Ittermann Alan L James Ingegerd Johansson Thorhildur Juliusdottir Ioanna-Panagiota Kalafati Leena Kinnunen Wolfgang Koenig Ishminder K Kooner Wolfgang Kratzer Claudia Lamina Karin Leander Nanette R Lee Peter Lichtner Lars Lind Jaana Lindström Stéphane Lobbens Mattias Lorentzon François Mach Patrik Ke Magnusson Anubha Mahajan Wendy L McArdle Cristina Menni Sigrun Merger Evelin Mihailov Lili Milani Rebecca Mills Alireza Moayyeri Keri L Monda Simon P Mooijaart Thomas W Mühleisen Antonella Mulas Gabriele Müller Martina Müller-Nurasyid Ramaiah Nagaraja Michael A Nalls Narisu Narisu Nicola Glorioso Ilja M Nolte Matthias Olden Nigel W Rayner Frida Renstrom Janina S Ried Neil R Robertson Lynda M Rose Serena Sanna Hubert Scharnagl Salome Scholtens Bengt Sennblad Thomas Seufferlein Colleen M Sitlani Albert Vernon Smith Kathleen Stirrups Heather M Stringham Johan Sundström Morris A Swertz Amy J Swift Ann-Christine Syvänen Bamidele O Tayo Barbara Thorand Gudmar Thorleifsson Andreas Tomaschitz Chiara Troffa Floor Va van Oort Niek Verweij Judith M Vonk Lindsay L Waite Roman Wennauer Tom Wilsgaard Mary K Wojczynski Andrew Wong Qunyuan Zhang Jing Hua Zhao Eoin P Brennan Murim Choi Per Eriksson Lasse Folkersen Anders Franco-Cereceda Ali G Gharavi Åsa K Hedman Marie-France Hivert Jinyan Huang Stavroula Kanoni Fredrik Karpe Sarah Keildson Krzysztof Kiryluk Liming Liang Richard P Lifton Baoshan Ma Amy J McKnight Ruth McPherson Andres Metspalu Josine L Min Miriam F Moffatt Grant W Montgomery Joanne M Murabito George Nicholson Dale R Nyholt Christian Olsson John Rb Perry Eva Reinmaa Rany M Salem Niina Sandholm Eric E Schadt Robert A Scott Lisette Stolk Edgar E Vallejo Harm-Jan Westra Krina T Zondervan Philippe Amouyel Dominique Arveiler Stephan Jl Bakker John Beilby Richard N Bergman John Blangero Morris J Brown Michel Burnier Harry Campbell Aravinda Chakravarti Peter S Chines Simone Claudi-Boehm Francis S Collins Dana C Crawford John Danesh Ulf de Faire Eco Jc de Geus Marcus Dörr Raimund Erbel Johan G Eriksson Martin Farrall Ele Ferrannini Jean Ferrières Nita G Forouhi Terrence Forrester Oscar H Franco Ron T Gansevoort Christian Gieger Vilmundur Gudnason Christopher A Haiman Tamara B Harris Andrew T Hattersley Markku Heliövaara Andrew A Hicks Aroon D Hingorani Wolfgang Hoffmann Albert Hofman Georg Homuth Steve E Humphries Elina Hyppönen Thomas Illig Marjo-Riitta Jarvelin Berit Johansen Pekka Jousilahti Antti M Jula Jaakko Kaprio Frank Kee Sirkka M Keinanen-Kiukaanniemi Jaspal S Kooner Charles Kooperberg Peter Kovacs Aldi T Kraja Meena Kumari Kari Kuulasmaa Johanna Kuusisto Timo A Lakka Claudia Langenberg Loic Le Marchand Terho Lehtimäki Valeriya Lyssenko Satu Männistö André Marette Tara C Matise Colin A McKenzie Barbara McKnight Arthur W Musk Stefan Möhlenkamp Andrew D Morris Mari Nelis Claes Ohlsson Albertine J Oldehinkel Ken K Ong Lyle J Palmer Brenda W Penninx Annette Peters Peter P Pramstaller Olli T Raitakari Tuomo Rankinen D C Rao Treva K Rice Paul M Ridker Marylyn D Ritchie Igor Rudan Veikko Salomaa Nilesh J Samani Jouko Saramies Mark A Sarzynski Peter Eh Schwarz Alan R Shuldiner Jan A Staessen Valgerdur Steinthorsdottir Ronald P Stolk Konstantin Strauch Anke Tönjes Angelo Tremblay Elena Tremoli Marie-Claude Vohl Uwe Völker Peter Vollenweider James F Wilson Jacqueline C Witteman Linda S Adair Murielle Bochud Bernhard O Boehm Stefan R Bornstein Claude Bouchard Stéphane Cauchi Mark J Caulfield John C Chambers Daniel I Chasman Richard S Cooper George Dedoussis Luigi Ferrucci Philippe Froguel Hans-Jörgen Grabe Anders Hamsten Jennie Hui Kristian Hveem Karl-Heinz Jöckel Mika Kivimaki Diana Kuh Markku Laakso Yongmei Liu Winfried März Patricia B Munroe Inger Njølstad Ben A Oostra Colin Na Palmer Nancy L Pedersen Markus Perola Louis Pérusse Ulrike Peters Chris Power Thomas Quertermous Rainer Rauramaa Fernando Rivadeneira Timo E Saaristo Danish Saleheen Juha Sinisalo P Eline Slagboom Harold Snieder Tim D Spector Kari Stefansson Michael Stumvoll Jaakko Tuomilehto André G Uitterlinden Matti Uusitupa Pim van der Harst Giovanni Veronesi Mark Walker Nicholas J Wareham Hugh Watkins H-Erich Wichmann Goncalo R Abecasis Themistocles L Assimes Sonja I Berndt Michael Boehnke Ingrid B Borecki Panos Deloukas Lude Franke Timothy M Frayling Leif C Groop David J Hunter Robert C Kaplan Jeffrey R O'Connell Lu Qi David Schlessinger David P Strachan Unnur Thorsteinsdottir Cornelia M van Duijn Cristen J Willer Peter M Visscher Jian Yang Joel N Hirschhorn M Carola Zillikens Mark I McCarthy Elizabeth K Speliotes Kari E North Caroline S Fox Inês Barroso Paul W Franks Erik Ingelsson Iris M Heid Ruth Jf Loos L Adrienne Cupples Andrew P Morris Cecilia M Lindgren Karen L Mohlke

Nature 2015 Feb;518(7538):187-196

Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA.

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February 2015

Genetic studies of body mass index yield new insights for obesity biology.

Authors:
Adam E Locke Bratati Kahali Sonja I Berndt Anne E Justice Tune H Pers Felix R Day Corey Powell Sailaja Vedantam Martin L Buchkovich Jian Yang Damien C Croteau-Chonka Tonu Esko Tove Fall Teresa Ferreira Stefan Gustafsson Zoltán Kutalik Jian'an Luan Reedik Mägi Joshua C Randall Thomas W Winkler Andrew R Wood Tsegaselassie Workalemahu Jessica D Faul Jennifer A Smith Jing Hua Zhao Wei Zhao Jin Chen Rudolf Fehrmann Åsa K Hedman Juha Karjalainen Ellen M Schmidt Devin Absher Najaf Amin Denise Anderson Marian Beekman Jennifer L Bolton Jennifer L Bragg-Gresham Steven Buyske Ayse Demirkan Guohong Deng Georg B Ehret Bjarke Feenstra Mary F Feitosa Krista Fischer Anuj Goel Jian Gong Anne U Jackson Stavroula Kanoni Marcus E Kleber Kati Kristiansson Unhee Lim Vaneet Lotay Massimo Mangino Irene Mateo Leach Carolina Medina-Gomez Sarah E Medland Michael A Nalls Cameron D Palmer Dorota Pasko Sonali Pechlivanis Marjolein J Peters Inga Prokopenko Dmitry Shungin Alena Stančáková Rona J Strawbridge Yun Ju Sung Toshiko Tanaka Alexander Teumer Stella Trompet Sander W van der Laan Jessica van Setten Jana V Van Vliet-Ostaptchouk Zhaoming Wang Loïc Yengo Weihua Zhang Aaron Isaacs Eva Albrecht Johan Ärnlöv Gillian M Arscott Antony P Attwood Stefania Bandinelli Amy Barrett Isabelita N Bas Claire Bellis Amanda J Bennett Christian Berne Roza Blagieva Matthias Blüher Stefan Böhringer Lori L Bonnycastle Yvonne Böttcher Heather A Boyd Marcel Bruinenberg Ida H Caspersen Yii-Der Ida Chen Robert Clarke E Warwick Daw Anton J M de Craen Graciela Delgado Maria Dimitriou Alex S F Doney Niina Eklund Karol Estrada Elodie Eury Lasse Folkersen Ross M Fraser Melissa E Garcia Frank Geller Vilmantas Giedraitis Bruna Gigante Alan S Go Alain Golay Alison H Goodall Scott D Gordon Mathias Gorski Hans-Jörgen Grabe Harald Grallert Tanja B Grammer Jürgen Gräßler Henrik Grönberg Christopher J Groves Gaëlle Gusto Jeffrey Haessler Per Hall Toomas Haller Goran Hallmans Catharina A Hartman Maija Hassinen Caroline Hayward Nancy L Heard-Costa Quinta Helmer Christian Hengstenberg Oddgeir Holmen Jouke-Jan Hottenga Alan L James Janina M Jeff Åsa Johansson Jennifer Jolley Thorhildur Juliusdottir Leena Kinnunen Wolfgang Koenig Markku Koskenvuo Wolfgang Kratzer Jaana Laitinen Claudia Lamina Karin Leander Nanette R Lee Peter Lichtner Lars Lind Jaana Lindström Ken Sin Lo Stéphane Lobbens Roberto Lorbeer Yingchang Lu François Mach Patrik K E Magnusson Anubha Mahajan Wendy L McArdle Stela McLachlan Cristina Menni Sigrun Merger Evelin Mihailov Lili Milani Alireza Moayyeri Keri L Monda Mario A Morken Antonella Mulas Gabriele Müller Martina Müller-Nurasyid Arthur W Musk Ramaiah Nagaraja Markus M Nöthen Ilja M Nolte Stefan Pilz Nigel W Rayner Frida Renstrom Rainer Rettig Janina S Ried Stephan Ripke Neil R Robertson Lynda M Rose Serena Sanna Hubert Scharnagl Salome Scholtens Fredrick R Schumacher William R Scott Thomas Seufferlein Jianxin Shi Albert Vernon Smith Joanna Smolonska Alice V Stanton Valgerdur Steinthorsdottir Kathleen Stirrups Heather M Stringham Johan Sundström Morris A Swertz Amy J Swift Ann-Christine Syvänen Sian-Tsung Tan Bamidele O Tayo Barbara Thorand Gudmar Thorleifsson Jonathan P Tyrer Hae-Won Uh Liesbeth Vandenput Frank C Verhulst Sita H Vermeulen Niek Verweij Judith M Vonk Lindsay L Waite Helen R Warren Dawn Waterworth Michael N Weedon Lynne R Wilkens Christina Willenborg Tom Wilsgaard Mary K Wojczynski Andrew Wong Alan F Wright Qunyuan Zhang Eoin P Brennan Murim Choi Zari Dastani Alexander W Drong Per Eriksson Anders Franco-Cereceda Jesper R Gådin Ali G Gharavi Michael E Goddard Robert E Handsaker Jinyan Huang Fredrik Karpe Sekar Kathiresan Sarah Keildson Krzysztof Kiryluk Michiaki Kubo Jong-Young Lee Liming Liang Richard P Lifton Baoshan Ma Steven A McCarroll Amy J McKnight Josine L Min Miriam F Moffatt Grant W Montgomery Joanne M Murabito George Nicholson Dale R Nyholt Yukinori Okada John R B Perry Rajkumar Dorajoo Eva Reinmaa Rany M Salem Niina Sandholm Robert A Scott Lisette Stolk Atsushi Takahashi Toshihiro Tanaka Ferdinand M van 't Hooft Anna A E Vinkhuyzen Harm-Jan Westra Wei Zheng Krina T Zondervan Andrew C Heath Dominique Arveiler Stephan J L Bakker John Beilby Richard N Bergman John Blangero Pascal Bovet Harry Campbell Mark J Caulfield Giancarlo Cesana Aravinda Chakravarti Daniel I Chasman Peter S Chines Francis S Collins Dana C Crawford L Adrienne Cupples Daniele Cusi John Danesh Ulf de Faire Hester M den Ruijter Anna F Dominiczak Raimund Erbel Jeanette Erdmann Johan G Eriksson Martin Farrall Stephan B Felix Ele Ferrannini Jean Ferrières Ian Ford Nita G Forouhi Terrence Forrester Oscar H Franco Ron T Gansevoort Pablo V Gejman Christian Gieger Omri Gottesman Vilmundur Gudnason Ulf Gyllensten Alistair S Hall Tamara B Harris Andrew T Hattersley Andrew A Hicks Lucia A Hindorff Aroon D Hingorani Albert Hofman Georg Homuth G Kees Hovingh Steve E Humphries Steven C Hunt Elina Hyppönen Thomas Illig Kevin B Jacobs Marjo-Riitta Jarvelin Karl-Heinz Jöckel Berit Johansen Pekka Jousilahti J Wouter Jukema Antti M Jula Jaakko Kaprio John J P Kastelein Sirkka M Keinanen-Kiukaanniemi Lambertus A Kiemeney Paul Knekt Jaspal S Kooner Charles Kooperberg Peter Kovacs Aldi T Kraja Meena Kumari Johanna Kuusisto Timo A Lakka Claudia Langenberg Loic Le Marchand Terho Lehtimäki Valeriya Lyssenko Satu Männistö André Marette Tara C Matise Colin A McKenzie Barbara McKnight Frans L Moll Andrew D Morris Andrew P Morris Jeffrey C Murray Mari Nelis Claes Ohlsson Albertine J Oldehinkel Ken K Ong Pamela A F Madden Gerard Pasterkamp John F Peden Annette Peters Dirkje S Postma Peter P Pramstaller Jackie F Price Lu Qi Olli T Raitakari Tuomo Rankinen D C Rao Treva K Rice Paul M Ridker John D Rioux Marylyn D Ritchie Igor Rudan Veikko Salomaa Nilesh J Samani Jouko Saramies Mark A Sarzynski Heribert Schunkert Peter E H Schwarz Peter Sever Alan R Shuldiner Juha Sinisalo Ronald P Stolk Konstantin Strauch Anke Tönjes David-Alexandre Trégouët Angelo Tremblay Elena Tremoli Jarmo Virtamo Marie-Claude Vohl Uwe Völker Gérard Waeber Gonneke Willemsen Jacqueline C Witteman M Carola Zillikens Linda S Adair Philippe Amouyel Folkert W Asselbergs Themistocles L Assimes Murielle Bochud Bernhard O Boehm Eric Boerwinkle Stefan R Bornstein Erwin P Bottinger Claude Bouchard Stéphane Cauchi John C Chambers Stephen J Chanock Richard S Cooper Paul I W de Bakker George Dedoussis Luigi Ferrucci Paul W Franks Philippe Froguel Leif C Groop Christopher A Haiman Anders Hamsten Jennie Hui David J Hunter Kristian Hveem Robert C Kaplan Mika Kivimaki Diana Kuh Markku Laakso Yongmei Liu Nicholas G Martin Winfried März Mads Melbye Andres Metspalu Susanne Moebus Patricia B Munroe Inger Njølstad Ben A Oostra Colin N A Palmer Nancy L Pedersen Markus Perola Louis Pérusse Ulrike Peters Chris Power Thomas Quertermous Rainer Rauramaa Fernando Rivadeneira Timo E Saaristo Danish Saleheen Naveed Sattar Eric E Schadt David Schlessinger P Eline Slagboom Harold Snieder Tim D Spector Unnur Thorsteinsdottir Michael Stumvoll Jaakko Tuomilehto André G Uitterlinden Matti Uusitupa Pim van der Harst Mark Walker Henri Wallaschofski Nicholas J Wareham Hugh Watkins David R Weir H-Erich Wichmann James F Wilson Pieter Zanen Ingrid B Borecki Panos Deloukas Caroline S Fox Iris M Heid Jeffrey R O'Connell David P Strachan Kari Stefansson Cornelia M van Duijn Gonçalo R Abecasis Lude Franke Timothy M Frayling Mark I McCarthy Peter M Visscher André Scherag Cristen J Willer Michael Boehnke Karen L Mohlke Cecilia M Lindgren Jacques S Beckmann Inês Barroso Kari E North Erik Ingelsson Joel N Hirschhorn Ruth J F Loos Elizabeth K Speliotes

Nature 2015 Feb;518(7538):197-206

Department of Internal Medicine, Division of Gastroenterology, and Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan 48109, USA.

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February 2015

Systematic annotation of celiac disease loci refines pathological pathways and suggests a genetic explanation for increased interferon-gamma levels.

Authors:
Vinod Kumar Javier Gutierrez-Achury Kartiek Kanduri Rodrigo Almeida Barbara Hrdlickova Daria V Zhernakova Harm-Jan Westra Juha Karjalainen Isis Ricaño-Ponce Yang Li Anna Stachurska Ettje F Tigchelaar Wayel H Abdulahad Harri Lähdesmäki Marten H Hofker Alexandra Zhernakova Lude Franke Riitta Lahesmaa Cisca Wijmenga Sebo Withoff

Hum Mol Genet 2015 Jan 4;24(2):397-409. Epub 2014 Sep 4.

Department of Genetics

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January 2015

Biological interpretation of genome-wide association studies using predicted gene functions.

Authors:
Tune H Pers Juha M Karjalainen Yingleong Chan Harm-Jan Westra Andrew R Wood Jian Yang Julian C Lui Sailaja Vedantam Stefan Gustafsson Tonu Esko Tim Frayling Elizabeth K Speliotes Michael Boehnke Soumya Raychaudhuri Rudolf S N Fehrmann Joel N Hirschhorn Lude Franke

Nat Commun 2015 Jan 19;6:5890. Epub 2015 Jan 19.

Department of Genetics, University of Groningen, University Medical Centre Groningen, Groningen 9711, The Netherlands.

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January 2015

Mediation analysis demonstrates that trans-eQTLs are often explained by cis-mediation: a genome-wide analysis among 1,800 South Asians.

Authors:
Brandon L Pierce Lin Tong Lin S Chen Ronald Rahaman Maria Argos Farzana Jasmine Shantanu Roy Rachelle Paul-Brutus Harm-Jan Westra Lude Franke Tonu Esko Rakibuz Zaman Tariqul Islam Mahfuzar Rahman John A Baron Muhammad G Kibriya Habibul Ahsan

PLoS Genet 2014 Dec 4;10(12):e1004818. Epub 2014 Dec 4.

Department of Public Health Sciences, The University of Chicago, Chicago, Illinois, United States of America; Comprehensive Cancer Center, The University of Chicago, Chicago, Illinois, United States of America; Department of Medicine The University of Chicago, Chicago, Illinois, United States of America; Department of Human Genetics, The University of Chicago, Chicago, Illinois, United States of America.

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December 2014

Genotype harmonizer: automatic strand alignment and format conversion for genotype data integration.

Authors:
Patrick Deelen Marc Jan Bonder K Joeri van der Velde Harm-Jan Westra Erwin Winder Dennis Hendriksen Lude Franke Morris A Swertz

BMC Res Notes 2014 Dec 11;7:901. Epub 2014 Dec 11.

University of Groningen, University Medical Center Groningen, Genomics Coordination Center, Groningen, the Netherlands.

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December 2014

Improved imputation quality of low-frequency and rare variants in European samples using the 'Genome of The Netherlands'.

Authors:
Patrick Deelen Androniki Menelaou Elisabeth M van Leeuwen Alexandros Kanterakis Freerk van Dijk Carolina Medina-Gomez Laurent C Francioli Jouke Jan Hottenga Lennart C Karssen Karol Estrada Eskil Kreiner-Møller Fernando Rivadeneira Jessica van Setten Javier Gutierrez-Achury Harm-Jan Westra Lude Franke David van Enckevort Martijn Dijkstra Heorhiy Byelas Cornelia M van Duijn Paul I W de Bakker Cisca Wijmenga Morris A Swertz

Eur J Hum Genet 2014 Nov 4;22(11):1321-6. Epub 2014 Jun 4.

1] University of Groningen, University Medical Center Groningen, Department of Genetics, Groningen, The Netherlands [2] University of Groningen, University Medical Center Groningen, Genomics Coordination Center, Groningen, The Netherlands.

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November 2014

Defining the role of common variation in the genomic and biological architecture of adult human height.

Authors:
Andrew R Wood Tonu Esko Jian Yang Sailaja Vedantam Tune H Pers Stefan Gustafsson Audrey Y Chu Karol Estrada Jian'an Luan Zoltán Kutalik Najaf Amin Martin L Buchkovich Damien C Croteau-Chonka Felix R Day Yanan Duan Tove Fall Rudolf Fehrmann Teresa Ferreira Anne U Jackson Juha Karjalainen Ken Sin Lo Adam E Locke Reedik Mägi Evelin Mihailov Eleonora Porcu Joshua C Randall André Scherag Anna A E Vinkhuyzen Harm-Jan Westra Thomas W Winkler Tsegaselassie Workalemahu Jing Hua Zhao Devin Absher Eva Albrecht Denise Anderson Jeffrey Baron Marian Beekman Ayse Demirkan Georg B Ehret Bjarke Feenstra Mary F Feitosa Krista Fischer Ross M Fraser Anuj Goel Jian Gong Anne E Justice Stavroula Kanoni Marcus E Kleber Kati Kristiansson Unhee Lim Vaneet Lotay Julian C Lui Massimo Mangino Irene Mateo Leach Carolina Medina-Gomez Michael A Nalls Dale R Nyholt Cameron D Palmer Dorota Pasko Sonali Pechlivanis Inga Prokopenko Janina S Ried Stephan Ripke Dmitry Shungin Alena Stancáková Rona J Strawbridge Yun Ju Sung Toshiko Tanaka Alexander Teumer Stella Trompet Sander W van der Laan Jessica van Setten Jana V Van Vliet-Ostaptchouk Zhaoming Wang Loïc Yengo Weihua Zhang Uzma Afzal Johan Arnlöv Gillian M Arscott Stefania Bandinelli Amy Barrett Claire Bellis Amanda J Bennett Christian Berne Matthias Blüher Jennifer L Bolton Yvonne Böttcher Heather A Boyd Marcel Bruinenberg Brendan M Buckley Steven Buyske Ida H Caspersen Peter S Chines Robert Clarke Simone Claudi-Boehm Matthew Cooper E Warwick Daw Pim A De Jong Joris Deelen Graciela Delgado Josh C Denny Rosalie Dhonukshe-Rutten Maria Dimitriou Alex S F Doney Marcus Dörr Niina Eklund Elodie Eury Lasse Folkersen Melissa E Garcia Frank Geller Vilmantas Giedraitis Alan S Go Harald Grallert Tanja B Grammer Jürgen Gräßler Henrik Grönberg Lisette C P G M de Groot Christopher J Groves Jeffrey Haessler Per Hall Toomas Haller Goran Hallmans Anke Hannemann Catharina A Hartman Maija Hassinen Caroline Hayward Nancy L Heard-Costa Quinta Helmer Gibran Hemani Anjali K Henders Hans L Hillege Mark A Hlatky Wolfgang Hoffmann Per Hoffmann Oddgeir Holmen Jeanine J Houwing-Duistermaat Thomas Illig Aaron Isaacs Alan L James Janina Jeff Berit Johansen Åsa Johansson Jennifer Jolley Thorhildur Juliusdottir Juhani Junttila Abel N Kho Leena Kinnunen Norman Klopp Thomas Kocher Wolfgang Kratzer Peter Lichtner Lars Lind Jaana Lindström Stéphane Lobbens Mattias Lorentzon Yingchang Lu Valeriya Lyssenko Patrik K E Magnusson Anubha Mahajan Marc Maillard Wendy L McArdle Colin A McKenzie Stela McLachlan Paul J McLaren Cristina Menni Sigrun Merger Lili Milani Alireza Moayyeri Keri L Monda Mario A Morken Gabriele Müller Martina Müller-Nurasyid Arthur W Musk Narisu Narisu Matthias Nauck Ilja M Nolte Markus M Nöthen Laticia Oozageer Stefan Pilz Nigel W Rayner Frida Renstrom Neil R Robertson Lynda M Rose Ronan Roussel Serena Sanna Hubert Scharnagl Salome Scholtens Fredrick R Schumacher Heribert Schunkert Robert A Scott Joban Sehmi Thomas Seufferlein Jianxin Shi Karri Silventoinen Johannes H Smit Albert Vernon Smith Joanna Smolonska Alice V Stanton Kathleen Stirrups David J Stott Heather M Stringham Johan Sundström Morris A Swertz Ann-Christine Syvänen Bamidele O Tayo Gudmar Thorleifsson Jonathan P Tyrer Suzanne van Dijk Natasja M van Schoor Nathalie van der Velde Diana van Heemst Floor V A van Oort Sita H Vermeulen Niek Verweij Judith M Vonk Lindsay L Waite Melanie Waldenberger Roman Wennauer Lynne R Wilkens Christina Willenborg Tom Wilsgaard Mary K Wojczynski Andrew Wong Alan F Wright Qunyuan Zhang Dominique Arveiler Stephan J L Bakker John Beilby Richard N Bergman Sven Bergmann Reiner Biffar John Blangero Dorret I Boomsma Stefan R Bornstein Pascal Bovet Paolo Brambilla Morris J Brown Harry Campbell Mark J Caulfield Aravinda Chakravarti Rory Collins Francis S Collins Dana C Crawford L Adrienne Cupples John Danesh Ulf de Faire Hester M den Ruijter Raimund Erbel Jeanette Erdmann Johan G Eriksson Martin Farrall Ele Ferrannini Jean Ferrières Ian Ford Nita G Forouhi Terrence Forrester Ron T Gansevoort Pablo V Gejman Christian Gieger Alain Golay Omri Gottesman Vilmundur Gudnason Ulf Gyllensten David W Haas Alistair S Hall Tamara B Harris Andrew T Hattersley Andrew C Heath Christian Hengstenberg Andrew A Hicks Lucia A Hindorff Aroon D Hingorani Albert Hofman G Kees Hovingh Steve E Humphries Steven C Hunt Elina Hypponen Kevin B Jacobs Marjo-Riitta Jarvelin Pekka Jousilahti Antti M Jula Jaakko Kaprio John J P Kastelein Manfred Kayser Frank Kee Sirkka M Keinanen-Kiukaanniemi Lambertus A Kiemeney Jaspal S Kooner Charles Kooperberg Seppo Koskinen Peter Kovacs Aldi T Kraja Meena Kumari Johanna Kuusisto Timo A Lakka Claudia Langenberg Loic Le Marchand Terho Lehtimäki Sara Lupoli Pamela A F Madden Satu Männistö Paolo Manunta André Marette Tara C Matise Barbara McKnight Thomas Meitinger Frans L Moll Grant W Montgomery Andrew D Morris Andrew P Morris Jeffrey C Murray Mari Nelis Claes Ohlsson Albertine J Oldehinkel Ken K Ong Willem H Ouwehand Gerard Pasterkamp Annette Peters Peter P Pramstaller Jackie F Price Lu Qi Olli T Raitakari Tuomo Rankinen D C Rao Treva K Rice Marylyn Ritchie Igor Rudan Veikko Salomaa Nilesh J Samani Jouko Saramies Mark A Sarzynski Peter E H Schwarz Sylvain Sebert Peter Sever Alan R Shuldiner Juha Sinisalo Valgerdur Steinthorsdottir Ronald P Stolk Jean-Claude Tardif Anke Tönjes Angelo Tremblay Elena Tremoli Jarmo Virtamo Marie-Claude Vohl Philippe Amouyel Folkert W Asselbergs Themistocles L Assimes Murielle Bochud Bernhard O Boehm Eric Boerwinkle Erwin P Bottinger Claude Bouchard Stéphane Cauchi John C Chambers Stephen J Chanock Richard S Cooper Paul I W de Bakker George Dedoussis Luigi Ferrucci Paul W Franks Philippe Froguel Leif C Groop Christopher A Haiman Anders Hamsten M Geoffrey Hayes Jennie Hui David J Hunter Kristian Hveem J Wouter Jukema Robert C Kaplan Mika Kivimaki Diana Kuh Markku Laakso Yongmei Liu Nicholas G Martin Winfried März Mads Melbye Susanne Moebus Patricia B Munroe Inger Njølstad Ben A Oostra Colin N A Palmer Nancy L Pedersen Markus Perola Louis Pérusse Ulrike Peters Joseph E Powell Chris Power Thomas Quertermous Rainer Rauramaa Eva Reinmaa Paul M Ridker Fernando Rivadeneira Jerome I Rotter Timo E Saaristo Danish Saleheen David Schlessinger P Eline Slagboom Harold Snieder Tim D Spector Konstantin Strauch Michael Stumvoll Jaakko Tuomilehto Matti Uusitupa Pim van der Harst Henry Völzke Mark Walker Nicholas J Wareham Hugh Watkins H-Erich Wichmann James F Wilson Pieter Zanen Panos Deloukas Iris M Heid Cecilia M Lindgren Karen L Mohlke Elizabeth K Speliotes Unnur Thorsteinsdottir Inês Barroso Caroline S Fox Kari E North David P Strachan Jacques S Beckmann Sonja I Berndt Michael Boehnke Ingrid B Borecki Mark I McCarthy Andres Metspalu Kari Stefansson André G Uitterlinden Cornelia M van Duijn Lude Franke Cristen J Willer Alkes L Price Guillaume Lettre Ruth J F Loos Michael N Weedon Erik Ingelsson Jeffrey R O'Connell Goncalo R Abecasis Daniel I Chasman Michael E Goddard Peter M Visscher Joel N Hirschhorn Timothy M Frayling

Nat Genet 2014 Nov 5;46(11):1173-86. Epub 2014 Oct 5.

Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, UK.

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November 2014

From genome to function by studying eQTLs.

Authors:
Harm-Jan Westra Lude Franke

Biochim Biophys Acta 2014 Oct 4;1842(10):1896-1902. Epub 2014 May 4.

University of Groningen, University Medical Center Groningen, Department of Genetics, Hanzeplein 1, 9700 RB Groningen, The Netherlands. Electronic address:

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October 2014

Hemani et al. reply.

Authors:
Gibran Hemani Konstantin Shakhbazov Harm-Jan Westra Tonu Esko Anjali K Henders Allan F McRae Jian Yang Greg Gibson Nicholas G Martin Andres Metspalu Lude Franke Grant W Montgomery Peter M Visscher Joseph E Powell

Nature 2014 Oct;514(7520):E5-6

1] Queensland Brain Institute, University of Queensland, Brisbane, Queensland 4072, Australia [2] University of Queensland Diamantina Institute, University of Queensland, Princess Alexandra Hospital, Brisbane, Queensland 4072, Australia.

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October 2014

Novel loci affecting iron homeostasis and their effects in individuals at risk for hemochromatosis.

Authors:
Beben Benyamin Tonu Esko Janina S Ried Aparna Radhakrishnan Sita H Vermeulen Michela Traglia Martin Gögele Denise Anderson Linda Broer Clara Podmore Jian'an Luan Zoltan Kutalik Serena Sanna Peter van der Meer Toshiko Tanaka Fudi Wang Harm-Jan Westra Lude Franke Evelin Mihailov Lili Milani Jonas Hälldin Jonas Häldin Juliane Winkelmann Thomas Meitinger Joachim Thiery Annette Peters Melanie Waldenberger Augusto Rendon Jennifer Jolley Jennifer Sambrook Lambertus A Kiemeney Fred C Sweep Cinzia F Sala Christine Schwienbacher Irene Pichler Jennie Hui Ayse Demirkan Aaron Isaacs Najaf Amin Maristella Steri Gérard Waeber Niek Verweij Joseph E Powell Dale R Nyholt Andrew C Heath Pamela A F Madden Peter M Visscher Margaret J Wright Grant W Montgomery Nicholas G Martin Dena Hernandez Stefania Bandinelli Pim van der Harst Manuela Uda Peter Vollenweider Robert A Scott Claudia Langenberg Nicholas J Wareham Cornelia van Duijn John Beilby Peter P Pramstaller Andrew A Hicks Willem H Ouwehand Konrad Oexle Christian Gieger Andres Metspalu Clara Camaschella Daniela Toniolo Dorine W Swinkels John B Whitfield

Nat Commun 2014 Oct 29;5:4926. Epub 2014 Oct 29.

QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4029, Australia.

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October 2014

Common variants in the HLA-DQ region confer susceptibility to idiopathic achalasia.

Authors:
Ines Gockel Jessica Becker Mira M Wouters Stefan Niebisch Henning R Gockel Timo Hess David Ramonet Julian Zimmermann Ana González Vigo Gosia Trynka Antonio Ruiz de León Julio Pérez de la Serna Elena Urcelay Vinod Kumar Lude Franke Harm-Jan Westra Daniel Drescher Werner Kneist Jens U Marquardt Peter R Galle Manuel Mattheisen Vito Annese Anna Latiano Uberto Fumagalli Luigi Laghi Rosario Cuomo Giovanni Sarnelli Michaela Müller Alexander J Eckardt Jan Tack Per Hoffmann Stefan Herms Elisabeth Mangold Stefanie Heilmann Ralf Kiesslich Burkhard H A von Rahden Hans-Dieter Allescher Henning G Schulz Cisca Wijmenga Michael T Heneka Hauke Lang Karl-Peter Hopfner Markus M Nöthen Guy E Boeckxstaens Paul I W de Bakker Michael Knapp Johannes Schumacher

Nat Genet 2014 Aug 6;46(8):901-4. Epub 2014 Jul 6.

1] Institute of Human Genetics, University of Bonn, Bonn, Germany. [2] Department of Genomics, Life &Brain Center, University of Bonn, Bonn, Germany. [3].

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http://dx.doi.org/10.1038/ng.3029DOI Listing
August 2014

Copper metabolism domain-containing 1 represses genes that promote inflammation and protects mice from colitis and colitis-associated cancer.

Authors:
Haiying Li Lillienne Chan Paulina Bartuzi Shelby D Melton Axel Weber Shani Ben-Shlomo Chen Varol Megan Raetz Xicheng Mao Petro Starokadomskyy Suzanne van Sommeren Mohamad Mokadem Heike Schneider Reid Weisberg Harm-Jan Westra Tõnu Esko Andres Metspalu Vinod Kumar William A Faubion Felix Yarovinsky Marten Hofker Cisca Wijmenga Michael Kracht Lude Franke Vincent Aguirre Rinse K Weersma Nathan Gluck Bart van de Sluis Ezra Burstein

Gastroenterology 2014 Jul 13;147(1):184-195.e3. Epub 2014 Apr 13.

Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas; Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas. Electronic address:

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4086320PMC
July 2014

Fine mapping of the celiac disease-associated LPP locus reveals a potential functional variant.

Authors:
Rodrigo Almeida Isis Ricaño-Ponce Vinod Kumar Patrick Deelen Agata Szperl Gosia Trynka Javier Gutierrez-Achury Alexandros Kanterakis Harm-Jan Westra Lude Franke Morris A Swertz Mathieu Platteel Jose Ramon Bilbao Donatella Barisani Luigi Greco Luisa Mearin Victorien M Wolters Chris Mulder Maria Cristina Mazzilli Ajit Sood Bozena Cukrowska Concepción Núñez Riccardo Pratesi Sebo Withoff Cisca Wijmenga

Hum Mol Genet 2014 May 11;23(9):2481-9. Epub 2013 Dec 11.

Department of Genetics, University of Groningen, University Medical Center Groningen, PO Box 30001, Groningen 9700 RB, The Netherlands.

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http://dx.doi.org/10.1093/hmg/ddt619DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3976328PMC
May 2014

Correlation of genetic risk and messenger RNA expression in a Th17/IL23 pathway analysis in inflammatory bowel disease.

Authors:
Karin Fransen Suzanne van Sommeren Harm-Jan Westra Monique Veenstra Letitia E Lamberts Rutger Modderman Gerard Dijkstra Jingyuan Fu Cisca Wijmenga Lude Franke Rinse K Weersma Cleo C van Diemen

Inflamm Bowel Dis 2014 May;20(5):777-82

Departments of *Genetics, and †Gastroenterology and Hepatology, University Medical Centre Groningen, University of Groningen, Groningen, the Netherlands.

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May 2014

Detection and replication of epistasis influencing transcription in humans.

Authors:
Gibran Hemani Konstantin Shakhbazov Harm-Jan Westra Tonu Esko Anjali K Henders Allan F McRae Jian Yang Greg Gibson Nicholas G Martin Andres Metspalu Lude Franke Grant W Montgomery Peter M Visscher Joseph E Powell

Nature 2014 Apr 26;508(7495):249-53. Epub 2014 Feb 26.

1] Queensland Brain Institute, University of Queensland, Brisbane, Queensland 4072, Australia [2] University of Queensland Diamantina Institute, University of Queensland, Princess Alexandra Hospital, Brisbane, Queensland 4072, Australia [3].

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3984375PMC
April 2014

Genetics of rheumatoid arthritis contributes to biology and drug discovery.

Authors:
Yukinori Okada Di Wu Gosia Trynka Towfique Raj Chikashi Terao Katsunori Ikari Yuta Kochi Koichiro Ohmura Akari Suzuki Shinji Yoshida Robert R Graham Arun Manoharan Ward Ortmann Tushar Bhangale Joshua C Denny Robert J Carroll Anne E Eyler Jeffrey D Greenberg Joel M Kremer Dimitrios A Pappas Lei Jiang Jian Yin Lingying Ye Ding-Feng Su Jian Yang Gang Xie Ed Keystone Harm-Jan Westra Tõnu Esko Andres Metspalu Xuezhong Zhou Namrata Gupta Daniel Mirel Eli A Stahl Dorothée Diogo Jing Cui Katherine Liao Michael H Guo Keiko Myouzen Takahisa Kawaguchi Marieke J H Coenen Piet L C M van Riel Mart A F J van de Laar Henk-Jan Guchelaar Tom W J Huizinga Philippe Dieudé Xavier Mariette S Louis Bridges Alexandra Zhernakova Rene E M Toes Paul P Tak Corinne Miceli-Richard So-Young Bang Hye-Soon Lee Javier Martin Miguel A Gonzalez-Gay Luis Rodriguez-Rodriguez Solbritt Rantapää-Dahlqvist Lisbeth Arlestig Hyon K Choi Yoichiro Kamatani Pilar Galan Mark Lathrop Steve Eyre John Bowes Anne Barton Niek de Vries Larry W Moreland Lindsey A Criswell Elizabeth W Karlson Atsuo Taniguchi Ryo Yamada Michiaki Kubo Jun S Liu Sang-Cheol Bae Jane Worthington Leonid Padyukov Lars Klareskog Peter K Gregersen Soumya Raychaudhuri Barbara E Stranger Philip L De Jager Lude Franke Peter M Visscher Matthew A Brown Hisashi Yamanaka Tsuneyo Mimori Atsushi Takahashi Huji Xu Timothy W Behrens Katherine A Siminovitch Shigeki Momohara Fumihiko Matsuda Kazuhiko Yamamoto Robert M Plenge

Nature 2014 Feb 25;506(7488):376-81. Epub 2013 Dec 25.

1] Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA. [2] Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA. [3] Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts 02142, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944098PMC
February 2014

Systematic identification of trans eQTLs as putative drivers of known disease associations.

Authors:
Harm-Jan Westra Marjolein J Peters Tõnu Esko Hanieh Yaghootkar Claudia Schurmann Johannes Kettunen Mark W Christiansen Benjamin P Fairfax Katharina Schramm Joseph E Powell Alexandra Zhernakova Daria V Zhernakova Jan H Veldink Leonard H Van den Berg Juha Karjalainen Sebo Withoff André G Uitterlinden Albert Hofman Fernando Rivadeneira Peter A C 't Hoen Eva Reinmaa Krista Fischer Mari Nelis Lili Milani David Melzer Luigi Ferrucci Andrew B Singleton Dena G Hernandez Michael A Nalls Georg Homuth Matthias Nauck Dörte Radke Uwe Völker Markus Perola Veikko Salomaa Jennifer Brody Astrid Suchy-Dicey Sina A Gharib Daniel A Enquobahrie Thomas Lumley Grant W Montgomery Seiko Makino Holger Prokisch Christian Herder Michael Roden Harald Grallert Thomas Meitinger Konstantin Strauch Yang Li Ritsert C Jansen Peter M Visscher Julian C Knight Bruce M Psaty Samuli Ripatti Alexander Teumer Timothy M Frayling Andres Metspalu Joyce B J van Meurs Lude Franke

Nat Genet 2013 Oct 8;45(10):1238-1243. Epub 2013 Sep 8.

Department of Genetics, University Medical Center Groningen, University of Groningen, Hanzeplein 1, Groningen, the Netherlands.

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http://dx.doi.org/10.1038/ng.2756DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3991562PMC
October 2013

Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders.

Authors:
Marcel den Hoed Mark Eijgelsheim Tõnu Esko Bianca J J M Brundel David S Peal David M Evans Ilja M Nolte Ayellet V Segrè Hilma Holm Robert E Handsaker Harm-Jan Westra Toby Johnson Aaron Isaacs Jian Yang Alicia Lundby Jing Hua Zhao Young Jin Kim Min Jin Go Peter Almgren Murielle Bochud Gabrielle Boucher Marilyn C Cornelis Daniel Gudbjartsson David Hadley Pim van der Harst Caroline Hayward Martin den Heijer Wilmar Igl Anne U Jackson Zoltán Kutalik Jian'an Luan John P Kemp Kati Kristiansson Claes Ladenvall Mattias Lorentzon May E Montasser Omer T Njajou Paul F O'Reilly Sandosh Padmanabhan Beate St Pourcain Tuomo Rankinen Perttu Salo Toshiko Tanaka Nicholas J Timpson Veronique Vitart Lindsay Waite William Wheeler Weihua Zhang Harmen H M Draisma Mary F Feitosa Kathleen F Kerr Penelope A Lind Evelin Mihailov N Charlotte Onland-Moret Ci Song Michael N Weedon Weijia Xie Loic Yengo Devin Absher Christine M Albert Alvaro Alonso Dan E Arking Paul I W de Bakker Beverley Balkau Cristina Barlassina Paola Benaglio Joshua C Bis Nabila Bouatia-Naji Søren Brage Stephen J Chanock Peter S Chines Mina Chung Dawood Darbar Christian Dina Marcus Dörr Paul Elliott Stephan B Felix Krista Fischer Christian Fuchsberger Eco J C de Geus Philippe Goyette Vilmundur Gudnason Tamara B Harris Anna-Liisa Hartikainen Aki S Havulinna Susan R Heckbert Andrew A Hicks Albert Hofman Suzanne Holewijn Femke Hoogstra-Berends Jouke-Jan Hottenga Majken K Jensen Asa Johansson Juhani Junttila Stefan Kääb Bart Kanon Shamika Ketkar Kay-Tee Khaw Joshua W Knowles Angrad S Kooner Jan A Kors Meena Kumari Lili Milani Päivi Laiho Edward G Lakatta Claudia Langenberg Maarten Leusink Yongmei Liu Robert N Luben Kathryn L Lunetta Stacey N Lynch Marcello R P Markus Pedro Marques-Vidal Irene Mateo Leach Wendy L McArdle Steven A McCarroll Sarah E Medland Kathryn A Miller Grant W Montgomery Alanna C Morrison Martina Müller-Nurasyid Pau Navarro Mari Nelis Jeffrey R O'Connell Christopher J O'Donnell Ken K Ong Anne B Newman Annette Peters Ozren Polasek Anneli Pouta Peter P Pramstaller Bruce M Psaty Dabeeru C Rao Susan M Ring Elizabeth J Rossin Diana Rudan Serena Sanna Robert A Scott Jaban S Sehmi Stephen Sharp Jordan T Shin Andrew B Singleton Albert V Smith Nicole Soranzo Tim D Spector Chip Stewart Heather M Stringham Kirill V Tarasov André G Uitterlinden Liesbeth Vandenput Shih-Jen Hwang John B Whitfield Cisca Wijmenga Sarah H Wild Gonneke Willemsen James F Wilson Jacqueline C M Witteman Andrew Wong Quenna Wong Yalda Jamshidi Paavo Zitting Jolanda M A Boer Dorret I Boomsma Ingrid B Borecki Cornelia M van Duijn Ulf Ekelund Nita G Forouhi Philippe Froguel Aroon Hingorani Erik Ingelsson Mika Kivimaki Richard A Kronmal Diana Kuh Lars Lind Nicholas G Martin Ben A Oostra Nancy L Pedersen Thomas Quertermous Jerome I Rotter Yvonne T van der Schouw W M Monique Verschuren Mark Walker Demetrius Albanes David O Arnar Themistocles L Assimes Stefania Bandinelli Michael Boehnke Rudolf A de Boer Claude Bouchard W L Mark Caulfield John C Chambers Gary Curhan Daniele Cusi Johan Eriksson Luigi Ferrucci Wiek H van Gilst Nicola Glorioso Jacqueline de Graaf Leif Groop Ulf Gyllensten Wen-Chi Hsueh Frank B Hu Heikki V Huikuri David J Hunter Carlos Iribarren Bo Isomaa Marjo-Riitta Jarvelin Antti Jula Mika Kähönen Lambertus A Kiemeney Melanie M van der Klauw Jaspal S Kooner Peter Kraft Licia Iacoviello Terho Lehtimäki Marja-Liisa L Lokki Braxton D Mitchell Gerjan Navis Markku S Nieminen Claes Ohlsson Neil R Poulter Lu Qi Olli T Raitakari Eric B Rimm John D Rioux Federica Rizzi Igor Rudan Veikko Salomaa Peter S Sever Denis C Shields Alan R Shuldiner Juha Sinisalo Alice V Stanton Ronald P Stolk David P Strachan Jean-Claude Tardif Unnur Thorsteinsdottir Jaako Tuomilehto Dirk J van Veldhuisen Jarmo Virtamo Jorma Viikari Peter Vollenweider Gérard Waeber Elisabeth Widen Yoon Shin Cho Jesper V Olsen Peter M Visscher Cristen Willer Lude Franke Jeanette Erdmann John R Thompson Arne Pfeufer Nona Sotoodehnia Christopher Newton-Cheh Patrick T Ellinor Bruno H Ch Stricker Andres Metspalu Markus Perola Jacques S Beckmann George Davey Smith Kari Stefansson Nicholas J Wareham Patricia B Munroe Ody C M Sibon David J Milan Harold Snieder Nilesh J Samani Ruth J F Loos

Nat Genet 2013 Jun 14;45(6):621-31. Epub 2013 Apr 14.

Medical Research Council MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK.

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June 2013

GWAS of 126,559 individuals identifies genetic variants associated with educational attainment.

Authors:
Cornelius A Rietveld Sarah E Medland Jaime Derringer Jian Yang Tõnu Esko Nicolas W Martin Harm-Jan Westra Konstantin Shakhbazov Abdel Abdellaoui Arpana Agrawal Eva Albrecht Behrooz Z Alizadeh Najaf Amin John Barnard Sebastian E Baumeister Kelly S Benke Lawrence F Bielak Jeffrey A Boatman Patricia A Boyle Gail Davies Christiaan de Leeuw Niina Eklund Daniel S Evans Rudolf Ferhmann Krista Fischer Christian Gieger Håkon K Gjessing Sara Hägg Jennifer R Harris Caroline Hayward Christina Holzapfel Carla A Ibrahim-Verbaas Erik Ingelsson Bo Jacobsson Peter K Joshi Astanand Jugessur Marika Kaakinen Stavroula Kanoni Juha Karjalainen Ivana Kolcic Kati Kristiansson Zoltán Kutalik Jari Lahti Sang H Lee Peng Lin Penelope A Lind Yongmei Liu Kurt Lohman Marisa Loitfelder George McMahon Pedro Marques Vidal Osorio Meirelles Lili Milani Ronny Myhre Marja-Liisa Nuotio Christopher J Oldmeadow Katja E Petrovic Wouter J Peyrot Ozren Polasek Lydia Quaye Eva Reinmaa John P Rice Thais S Rizzi Helena Schmidt Reinhold Schmidt Albert V Smith Jennifer A Smith Toshiko Tanaka Antonio Terracciano Matthijs J H M van der Loos Veronique Vitart Henry Völzke Jürgen Wellmann Lei Yu Wei Zhao Jüri Allik John R Attia Stefania Bandinelli François Bastardot Jonathan Beauchamp David A Bennett Klaus Berger Laura J Bierut Dorret I Boomsma Ute Bültmann Harry Campbell Christopher F Chabris Lynn Cherkas Mina K Chung Francesco Cucca Mariza de Andrade Philip L De Jager Jan-Emmanuel De Neve Ian J Deary George V Dedoussis Panos Deloukas Maria Dimitriou Guðny Eiríksdóttir Martin F Elderson Johan G Eriksson David M Evans Jessica D Faul Luigi Ferrucci Melissa E Garcia Henrik Grönberg Vilmundur Guðnason Per Hall Juliette M Harris Tamara B Harris Nicholas D Hastie Andrew C Heath Dena G Hernandez Wolfgang Hoffmann Adriaan Hofman Rolf Holle Elizabeth G Holliday Jouke-Jan Hottenga William G Iacono Thomas Illig Marjo-Riitta Järvelin Mika Kähönen Jaakko Kaprio Robert M Kirkpatrick Matthew Kowgier Antti Latvala Lenore J Launer Debbie A Lawlor Terho Lehtimäki Jingmei Li Paul Lichtenstein Peter Lichtner David C Liewald Pamela A Madden Patrik K E Magnusson Tomi E Mäkinen Marco Masala Matt McGue Andres Metspalu Andreas Mielck Michael B Miller Grant W Montgomery Sutapa Mukherjee Dale R Nyholt Ben A Oostra Lyle J Palmer Aarno Palotie Brenda W J H Penninx Markus Perola Patricia A Peyser Martin Preisig Katri Räikkönen Olli T Raitakari Anu Realo Susan M Ring Samuli Ripatti Fernando Rivadeneira Igor Rudan Aldo Rustichini Veikko Salomaa Antti-Pekka Sarin David Schlessinger Rodney J Scott Harold Snieder Beate St Pourcain John M Starr Jae Hoon Sul Ida Surakka Rauli Svento Alexander Teumer Henning Tiemeier Frank J A van Rooij David R Van Wagoner Erkki Vartiainen Jorma Viikari Peter Vollenweider Judith M Vonk Gérard Waeber David R Weir H-Erich Wichmann Elisabeth Widen Gonneke Willemsen James F Wilson Alan F Wright Dalton Conley George Davey-Smith Lude Franke Patrick J F Groenen Albert Hofman Magnus Johannesson Sharon L R Kardia Robert F Krueger David Laibson Nicholas G Martin Michelle N Meyer Danielle Posthuma A Roy Thurik Nicholas J Timpson André G Uitterlinden Cornelia M van Duijn Peter M Visscher Daniel J Benjamin David Cesarini Philipp D Koellinger

Science 2013 Jun 30;340(6139):1467-71. Epub 2013 May 30.

Department of Applied Economics, Erasmus School of Economics, Erasmus University Rotterdam, Rotterdam, Netherlands.

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June 2013

DeepSAGE reveals genetic variants associated with alternative polyadenylation and expression of coding and non-coding transcripts.

Authors:
Daria V Zhernakova Eleonora de Klerk Harm-Jan Westra Anastasios Mastrokolias Shoaib Amini Yavuz Ariyurek Rick Jansen Brenda W Penninx Jouke J Hottenga Gonneke Willemsen Eco J de Geus Dorret I Boomsma Jan H Veldink Leonard H van den Berg Cisca Wijmenga Johan T den Dunnen Gert-Jan B van Ommen Peter A C 't Hoen Lude Franke

PLoS Genet 2013 Jun 20;9(6):e1003594. Epub 2013 Jun 20.

University of Groningen, University Medical Center Groningen, Department of Genetics, Groningen, The Netherlands.

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June 2013

A genome-wide association study of circulating galectin-3.

Authors:
Rudolf A de Boer Niek Verweij Dirk J van Veldhuisen Harm-Jan Westra Stephan J L Bakker Ron T Gansevoort Anneke C Muller Kobold Wiek H van Gilst Lude Franke Irene Mateo Leach Pim van der Harst

PLoS One 2012 9;7(10):e47385. Epub 2012 Oct 9.

Department of Cardiology, University of Groningen, University Medical Center Groningen, The Netherlands.

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May 2013

Human disease-associated genetic variation impacts large intergenic non-coding RNA expression.

Authors:
Vinod Kumar Harm-Jan Westra Juha Karjalainen Daria V Zhernakova Tõnu Esko Barbara Hrdlickova Rodrigo Almeida Alexandra Zhernakova Eva Reinmaa Urmo Võsa Marten H Hofker Rudolf S N Fehrmann Jingyuan Fu Sebo Withoff Andres Metspalu Lude Franke Cisca Wijmenga

PLoS Genet 2013 17;9(1):e1003201. Epub 2013 Jan 17.

Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

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May 2013

SMIM1 underlies the Vel blood group and influences red blood cell traits.

Authors:
Ana Cvejic Lonneke Haer-Wigman Jonathan C Stephens Myrto Kostadima Peter A Smethurst Mattia Frontini Emile van den Akker Paul Bertone Ewa Bielczyk-Maczyńska Samantha Farrow Rudolf Sn Fehrmann Alan Gray Masja de Haas Vincent G Haver Gregory Jordan Juha Karjalainen Hindrik Hd Kerstens Graham Kiddle Heather Lloyd-Jones Malcolm Needs Joyce Poole Aicha Ait Soussan Augusto Rendon Klaus Rieneck Jennifer G Sambrook Hein Schepers Herman H W Silljé Botond Sipos Dorine Swinkels Asif U Tamuri Niek Verweij Nicholas A Watkins Harm-Jan Westra Derek Stemple Lude Franke Nicole Soranzo Hendrik G Stunnenberg Nick Goldman Pim van der Harst C Ellen van der Schoot Willem H Ouwehand Cornelis A Albers

Nat Genet 2013 May 7;45(5):542-545. Epub 2013 Apr 7.

Department of Haematology, University of Cambridge, CB2 0PT, United Kingdom.

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May 2013

High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis.

Authors:
Steve Eyre John Bowes Dorothée Diogo Annette Lee Anne Barton Paul Martin Alexandra Zhernakova Eli Stahl Sebastien Viatte Kate McAllister Christopher I Amos Leonid Padyukov Rene E M Toes Tom W J Huizinga Cisca Wijmenga Gosia Trynka Lude Franke Harm-Jan Westra Lars Alfredsson Xinli Hu Cynthia Sandor Paul I W de Bakker Sonia Davila Chiea Chuen Khor Khai Koon Heng Robert Andrews Sarah Edkins Sarah E Hunt Cordelia Langford Deborah Symmons Pat Concannon Suna Onengut-Gumuscu Stephen S Rich Panos Deloukas Miguel A Gonzalez-Gay Luis Rodriguez-Rodriguez Lisbeth Ärlsetig Javier Martin Solbritt Rantapää-Dahlqvist Robert M Plenge Soumya Raychaudhuri Lars Klareskog Peter K Gregersen Jane Worthington

Nat Genet 2012 Dec 11;44(12):1336-40. Epub 2012 Nov 11.

Arthritis Research UK Epidemiology Unit, Centre for Musculoskeletal Research, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.

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December 2012

Seventy-five genetic loci influencing the human red blood cell.

Authors:
Pim van der Harst Weihua Zhang Irene Mateo Leach Augusto Rendon Niek Verweij Joban Sehmi Dirk S Paul Ulrich Elling Hooman Allayee Xinzhong Li Aparna Radhakrishnan Sian-Tsung Tan Katrin Voss Christian X Weichenberger Cornelis A Albers Abtehale Al-Hussani Folkert W Asselbergs Marina Ciullo Fabrice Danjou Christian Dina Tõnu Esko David M Evans Lude Franke Martin Gögele Jaana Hartiala Micha Hersch Hilma Holm Jouke-Jan Hottenga Stavroula Kanoni Marcus E Kleber Vasiliki Lagou Claudia Langenberg Lorna M Lopez Leo-Pekka Lyytikäinen Olle Melander Federico Murgia Ilja M Nolte Paul F O'Reilly Sandosh Padmanabhan Afshin Parsa Nicola Pirastu Eleonora Porcu Laura Portas Inga Prokopenko Janina S Ried So-Youn Shin Clara S Tang Alexander Teumer Michela Traglia Sheila Ulivi Harm-Jan Westra Jian Yang Jing Hua Zhao Franco Anni Abdel Abdellaoui Antony Attwood Beverley Balkau Stefania Bandinelli François Bastardot Beben Benyamin Bernhard O Boehm William O Cookson Debashish Das Paul I W de Bakker Rudolf A de Boer Eco J C de Geus Marleen H de Moor Maria Dimitriou Francisco S Domingues Angela Döring Gunnar Engström Gudmundur Ingi Eyjolfsson Luigi Ferrucci Krista Fischer Renzo Galanello Stephen F Garner Bernd Genser Quince D Gibson Giorgia Girotto Daniel Fannar Gudbjartsson Sarah E Harris Anna-Liisa Hartikainen Claire E Hastie Bo Hedblad Thomas Illig Jennifer Jolley Mika Kähönen Ido P Kema John P Kemp Liming Liang Heather Lloyd-Jones Ruth J F Loos Stuart Meacham Sarah E Medland Christa Meisinger Yasin Memari Evelin Mihailov Kathy Miller Miriam F Moffatt Matthias Nauck Maria Novatchkova Teresa Nutile Isleifur Olafsson Pall T Onundarson Debora Parracciani Brenda W Penninx Lucia Perseu Antonio Piga Giorgio Pistis Anneli Pouta Ursula Puc Olli Raitakari Susan M Ring Antonietta Robino Daniela Ruggiero Aimo Ruokonen Aude Saint-Pierre Cinzia Sala Andres Salumets Jennifer Sambrook Hein Schepers Carsten Oliver Schmidt Herman H W Silljé Rob Sladek Johannes H Smit John M Starr Jonathan Stephens Patrick Sulem Toshiko Tanaka Unnur Thorsteinsdottir Vinicius Tragante Wiek H van Gilst L Joost van Pelt Dirk J van Veldhuisen Uwe Völker John B Whitfield Gonneke Willemsen Bernhard R Winkelmann Gerald Wirnsberger Ale Algra Francesco Cucca Adamo Pio d'Adamo John Danesh Ian J Deary Anna F Dominiczak Paul Elliott Paolo Fortina Philippe Froguel Paolo Gasparini Andreas Greinacher Stanley L Hazen Marjo-Riitta Jarvelin Kay Tee Khaw Terho Lehtimäki Winfried Maerz Nicholas G Martin Andres Metspalu Braxton D Mitchell Grant W Montgomery Carmel Moore Gerjan Navis Mario Pirastu Peter P Pramstaller Ramiro Ramirez-Solis Eric Schadt James Scott Alan R Shuldiner George Davey Smith J Gustav Smith Harold Snieder Rossella Sorice Tim D Spector Kari Stefansson Michael Stumvoll W H Wilson Tang Daniela Toniolo Anke Tönjes Peter M Visscher Peter Vollenweider Nicholas J Wareham Bruce H R Wolffenbuttel Dorret I Boomsma Jacques S Beckmann George V Dedoussis Panos Deloukas Manuel A Ferreira Serena Sanna Manuela Uda Andrew A Hicks Josef Martin Penninger Christian Gieger Jaspal S Kooner Willem H Ouwehand Nicole Soranzo John C Chambers

Nature 2012 Dec 5;492(7429):369-75. Epub 2012 Dec 5.

Department of Cardiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands.

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December 2012

Discovery and fine mapping of serum protein loci through transethnic meta-analysis.

Authors:
Nora Franceschini Frank J A van Rooij Bram P Prins Mary F Feitosa Mahir Karakas John H Eckfeldt Aaron R Folsom Jeffrey Kopp Ahmad Vaez Jeanette S Andrews Jens Baumert Vesna Boraska Linda Broer Caroline Hayward Julius S Ngwa Yukinori Okada Ozren Polasek Harm-Jan Westra Ying A Wang Fabiola Del Greco M Nicole L Glazer Karen Kapur Ido P Kema Lorna M Lopez Arne Schillert Albert V Smith Cheryl A Winkler Lina Zgaga Stefania Bandinelli Sven Bergmann Mladen Boban Murielle Bochud Y D Chen Gail Davies Abbas Dehghan Jingzhong Ding Angela Doering J Peter Durda Luigi Ferrucci Oscar H Franco Lude Franke Grog Gunjaca Albert Hofman Fang-Chi Hsu Ivana Kolcic Aldi Kraja Michiaki Kubo Karl J Lackner Lenore Launer Laura R Loehr Guo Li Christa Meisinger Yusuke Nakamura Christine Schwienbacher John M Starr Atsushi Takahashi Vesela Torlak André G Uitterlinden Veronique Vitart Melanie Waldenberger Philipp S Wild Mirna Kirin Tanja Zeller Tatijana Zemunik Qunyuan Zhang Andreas Ziegler Stefan Blankenberg Eric Boerwinkle Ingrid B Borecki Harry Campbell Ian J Deary Timothy M Frayling Christian Gieger Tamara B Harris Andrew A Hicks Wolfgang Koenig Christopher J O' Donnell Caroline S Fox Peter P Pramstaller Bruce M Psaty Alex P Reiner Jerome I Rotter Igor Rudan Harold Snieder Toshihiro Tanaka Cornelia M van Duijn Peter Vollenweider Gerard Waeber James F Wilson Jacqueline C M Witteman Bruce H R Wolffenbuttel Alan F Wright Qingyu Wu Yongmei Liu Nancy S Jenny Kari E North Janine F Felix Behrooz Z Alizadeh L Adrienne Cupples John R B Perry Andrew P Morris

Am J Hum Genet 2012 Oct 27;91(4):744-53. Epub 2012 Sep 27.

Department of Epidemiology, University of North Carolina, Chapel Hill, NC 27599, USA.

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October 2012

Unraveling the regulatory mechanisms underlying tissue-dependent genetic variation of gene expression.

Authors:
Jingyuan Fu Marcel G M Wolfs Patrick Deelen Harm-Jan Westra Rudolf S N Fehrmann Gerard J Te Meerman Wim A Buurman Sander S M Rensen Harry J M Groen Rinse K Weersma Leonard H van den Berg Jan Veldink Roel A Ophoff Harold Snieder David van Heel Ritsert C Jansen Marten H Hofker Cisca Wijmenga Lude Franke

PLoS Genet 2012 Jan 19;8(1):e1002431. Epub 2012 Jan 19.

Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

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http://dx.doi.org/10.1371/journal.pgen.1002431DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3261927PMC
January 2012

A genome-wide association study identifies a region at chromosome 12 as a potential susceptibility locus for restenosis after percutaneous coronary intervention.

Authors:
M Lourdes Sampietro Stella Trompet Jeffrey J W Verschuren Rudolf P Talens Joris Deelen Bastiaan T Heijmans Robbert J de Winter Rene A Tio Pieter A F M Doevendans Santhi K Ganesh Elizabeth G Nabel Harm-Jan Westra Lude Franke Erik B van den Akker Rudi G J Westendorp Aeilko H Zwinderman Adnan Kastrati Werner Koch P Eline Slagboom Peter de Knijff J Wouter Jukema

Hum Mol Genet 2011 Dec 30;20(23):4748-57. Epub 2011 Aug 30.

Department of Human Genetics, Leiden University Medical Center, Leiden 2300RC, The Netherlands.

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https://academic.oup.com/hmg/article-lookup/doi/10.1093/hmg/
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http://dx.doi.org/10.1093/hmg/ddr389DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3209827PMC
December 2011

Blood pressure loci identified with a gene-centric array.

Authors:
Toby Johnson Tom R Gaunt Stephen J Newhouse Sandosh Padmanabhan Maciej Tomaszewski Meena Kumari Richard W Morris Ioanna Tzoulaki Eoin T O'Brien Neil R Poulter Peter Sever Denis C Shields Simon Thom Sasiwarang G Wannamethee Peter H Whincup Morris J Brown John M Connell Richard J Dobson Philip J Howard Charles A Mein Abiodun Onipinla Sue Shaw-Hawkins Yun Zhang George Davey Smith Ian N M Day Debbie A Lawlor Alison H Goodall F Gerald Fowkes Gonçalo R Abecasis Paul Elliott Vesela Gateva Peter S Braund Paul R Burton Christopher P Nelson Martin D Tobin Pim van der Harst Nicola Glorioso Hani Neuvrith Erika Salvi Jan A Staessen Andrea Stucchi Nabila Devos Xavier Jeunemaitre Pierre-François Plouin Jean Tichet Peeter Juhanson Elin Org Margus Putku Siim Sõber Gudrun Veldre Margus Viigimaa Anna Levinsson Annika Rosengren Dag S Thelle Claire E Hastie Thomas Hedner Wai K Lee Olle Melander Björn Wahlstrand Rebecca Hardy Andrew Wong Jackie A Cooper Jutta Palmen Li Chen Alexandre F R Stewart George A Wells Harm-Jan Westra Marcel G M Wolfs Robert Clarke Maria Grazia Franzosi Anuj Goel Anders Hamsten Mark Lathrop John F Peden Udo Seedorf Hugh Watkins Willem H Ouwehand Jennifer Sambrook Jonathan Stephens Juan-Pablo Casas Fotios Drenos Michael V Holmes Mika Kivimaki Sonia Shah Tina Shah Philippa J Talmud John Whittaker Chris Wallace Christian Delles Maris Laan Diana Kuh Steve E Humphries Fredrik Nyberg Daniele Cusi Robert Roberts Christopher Newton-Cheh Lude Franke Alice V Stanton Anna F Dominiczak Martin Farrall Aroon D Hingorani Nilesh J Samani Mark J Caulfield Patricia B Munroe

Am J Hum Genet 2011 Dec 17;89(6):688-700. Epub 2011 Nov 17.

Clinical Pharmacology and Barts and The London Genome Centre, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London, UK.

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http://dx.doi.org/10.1016/j.ajhg.2011.10.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3234370PMC
December 2011

MixupMapper: correcting sample mix-ups in genome-wide datasets increases power to detect small genetic effects.

Authors:
Harm-Jan Westra Ritsert C Jansen Rudolf S N Fehrmann Gerard J te Meerman David van Heel Cisca Wijmenga Lude Franke

Bioinformatics 2011 Aug 7;27(15):2104-11. Epub 2011 Jun 7.

Department of Genetics, University Medical Center Groningen, Groningen, The Netherlands.

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http://dx.doi.org/10.1093/bioinformatics/btr323DOI Listing
August 2011

Trans-eQTLs reveal that independent genetic variants associated with a complex phenotype converge on intermediate genes, with a major role for the HLA.

Authors:
Rudolf S N Fehrmann Ritsert C Jansen Jan H Veldink Harm-Jan Westra Danny Arends Marc Jan Bonder Jingyuan Fu Patrick Deelen Harry J M Groen Asia Smolonska Rinse K Weersma Robert M W Hofstra Wim A Buurman Sander Rensen Marcel G M Wolfs Mathieu Platteel Alexandra Zhernakova Clara C Elbers Eleanora M Festen Gosia Trynka Marten H Hofker Christiaan G J Saris Roel A Ophoff Leonard H van den Berg David A van Heel Cisca Wijmenga Gerard J Te Meerman Lude Franke

PLoS Genet 2011 Aug 4;7(8):e1002197. Epub 2011 Aug 4.

Department of Genetics, University Medical Center Groningen and University of Groningen, Groningen, The Netherlands.

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http://dx.doi.org/10.1371/journal.pgen.1002197DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3150446PMC
August 2011

Three ulcerative colitis susceptibility loci are associated with primary sclerosing cholangitis and indicate a role for IL2, REL, and CARD9.

Authors:
Marcel Janse Laetitia E Lamberts Lude Franke Soumya Raychaudhuri Eva Ellinghaus Kirsten Muri Boberg Espen Melum Trine Folseraas Erik Schrumpf Annika Bergquist Einar Björnsson Jingyuan Fu Harm Jan Westra Harry J M Groen Rudolf S N Fehrmann Joanna Smolonska Leonard H van den Berg Roel A Ophoff Robert J Porte Tobias J Weismüller Jochen Wedemeyer Christoph Schramm Martina Sterneck Rainer Günther Felix Braun Severine Vermeire Liesbet Henckaerts Cisca Wijmenga Cyriel Y Ponsioen Stefan Schreiber Tom H Karlsen Andre Franke Rinse K Weersma

Hepatology 2011 Jun 2;53(6):1977-85. Epub 2011 May 2.

Department of Gastroenterology and Hepatology, University Medical Center Groningen and University of Groningen, Groningen, The Netherlands.

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http://dx.doi.org/10.1002/hep.24307DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3121050PMC
June 2011

Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.

Authors:
Carl A Anderson Gabrielle Boucher Charlie W Lees Andre Franke Mauro D'Amato Kent D Taylor James C Lee Philippe Goyette Marcin Imielinski Anna Latiano Caroline Lagacé Regan Scott Leila Amininejad Suzannah Bumpstead Leonard Baidoo Robert N Baldassano Murray Barclay Theodore M Bayless Stephan Brand Carsten Büning Jean-Frédéric Colombel Lee A Denson Martine De Vos Marla Dubinsky Cathryn Edwards David Ellinghaus Rudolf S N Fehrmann James A B Floyd Timothy Florin Denis Franchimont Lude Franke Michel Georges Jürgen Glas Nicole L Glazer Stephen L Guthery Talin Haritunians Nicholas K Hayward Jean-Pierre Hugot Gilles Jobin Debby Laukens Ian Lawrance Marc Lémann Arie Levine Cecile Libioulle Edouard Louis Dermot P McGovern Monica Milla Grant W Montgomery Katherine I Morley Craig Mowat Aylwin Ng William Newman Roel A Ophoff Laura Papi Orazio Palmieri Laurent Peyrin-Biroulet Julián Panés Anne Phillips Natalie J Prescott Deborah D Proctor Rebecca Roberts Richard Russell Paul Rutgeerts Jeremy Sanderson Miquel Sans Philip Schumm Frank Seibold Yashoda Sharma Lisa A Simms Mark Seielstad A Hillary Steinhart Stephan R Targan Leonard H van den Berg Morten Vatn Hein Verspaget Thomas Walters Cisca Wijmenga David C Wilson Harm-Jan Westra Ramnik J Xavier Zhen Z Zhao Cyriel Y Ponsioen Vibeke Andersen Leif Torkvist Maria Gazouli Nicholas P Anagnou Tom H Karlsen Limas Kupcinskas Jurgita Sventoraityte John C Mansfield Subra Kugathasan Mark S Silverberg Jonas Halfvarson Jerome I Rotter Christopher G Mathew Anne M Griffiths Richard Gearry Tariq Ahmad Steven R Brant Mathias Chamaillard Jack Satsangi Judy H Cho Stefan Schreiber Mark J Daly Jeffrey C Barrett Miles Parkes Vito Annese Hakon Hakonarson Graham Radford-Smith Richard H Duerr Séverine Vermeire Rinse K Weersma John D Rioux

Nat Genet 2011 Mar 6;43(3):246-52. Epub 2011 Feb 6.

Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK.

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http://dx.doi.org/10.1038/ng.764DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3084597PMC
March 2011

Meta-analysis of genome-wide association studies in celiac disease and rheumatoid arthritis identifies fourteen non-HLA shared loci.

Authors:
Alexandra Zhernakova Eli A Stahl Gosia Trynka Soumya Raychaudhuri Eleanora A Festen Lude Franke Harm-Jan Westra Rudolf S N Fehrmann Fina A S Kurreeman Brian Thomson Namrata Gupta Jihane Romanos Ross McManus Anthony W Ryan Graham Turner Elisabeth Brouwer Marcel D Posthumus Elaine F Remmers Francesca Tucci Rene Toes Elvira Grandone Maria Cristina Mazzilli Anna Rybak Bozena Cukrowska Marieke J H Coenen Timothy R D J Radstake Piet L C M van Riel Yonghong Li Paul I W de Bakker Peter K Gregersen Jane Worthington Katherine A Siminovitch Lars Klareskog Tom W J Huizinga Cisca Wijmenga Robert M Plenge

PLoS Genet 2011 Feb 24;7(2):e1002004. Epub 2011 Feb 24.

Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1371/journal.pgen.1002004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3044685PMC
February 2011