Publications by authors named "Harald Steiner"

89Publications

γ-Secretase cleavage of the Alzheimer risk factor TREM2 is determined by its intrinsic structural dynamics.

Authors:
Andrea Steiner Kai Schlepckow Bettina Brunner Harald Steiner Christian Haass Franz Hagn

EMBO J 2020 Oct 24;39(20):e104247. Epub 2020 Aug 24.

Bavarian NMR Center at the Department of Chemistry and Institute for Advanced Study, Technical University of Munich, Garching, Germany.

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October 2020

Understanding intramembrane proteolysis by γ-secretase.

Authors:
Harald Steiner

Semin Cell Dev Biol 2020 09 18;105:1-2. Epub 2020 Jun 18.

Biomedical Center (BMC), Metabolic Biochemistry, Ludwig-Maximilians-University, Munich, Feodor-Lynen-Str. 17, 81377, Munich, Germany; German Center for Neurodegenerative Diseases (DZNE), Munich, Feodor-Lynen-Str. 17, 81377, Munich, Germany. Electronic address:

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September 2020

Substrate recruitment by γ-secretase.

Authors:
Akio Fukumori Lukas P Feilen Harald Steiner

Semin Cell Dev Biol 2020 09 22;105:54-63. Epub 2020 Apr 22.

German Center for Neurodegenerative Diseases (DZNE), Munich, Feodor-Lynen-Str. 17, 81377, Munich, Germany; Biomedical Center (BMC), Metabolic Biochemistry, Ludwig-Maximilians-University, Munich, Feodor-Lynen-Str. 17, 81377, Munich, Germany. Electronic address:

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September 2020

Pathogenic Aβ generation in familial Alzheimer's disease: novel mechanistic insights and therapeutic implications.

Authors:
Johannes Trambauer Akio Fukumori Harald Steiner

Curr Opin Neurobiol 2020 04 24;61:73-81. Epub 2020 Feb 24.

Biomedical Center (BMC), Metabolic Biochemistry, Ludwig-Maximilians-University, Munich, Feodor-Lynen-Str. 17, 81377 Munich, Germany; German Center for Neurodegenerative Diseases (DZNE), Munich, Feodor-Lynen-Str. 17, 81377 Munich, Germany. Electronic address:

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April 2020

Photo-controlled delivery of very long chain fatty acids to cell membranes and modulation of membrane protein function.

Authors:
Li Kong Edgar Dawkins Frederick Campbell Edith Winkler Rico J E Derks Martin Giera Frits Kamp Harald Steiner Alexander Kros

Biochim Biophys Acta Biomembr 2020 05 20;1862(5):183200. Epub 2020 Jan 20.

Leiden Institute of Chemistry, Leiden University, 2300 RA Leiden, the Netherlands. Electronic address:

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May 2020

Aβ43-producing PS1 FAD mutants cause altered substrate interactions and respond to γ-secretase modulation.

Authors:
Johannes Trambauer Rosa María Rodríguez Sarmiento Akio Fukumori Regina Feederle Karlheinz Baumann Harald Steiner

EMBO Rep 2020 01 25;21(1):e47996. Epub 2019 Nov 25.

Biomedical Center (BMC), Metabolic Biochemistry, Ludwig-Maximilians-University, Munich, Germany.

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January 2020

Identification of a rare presenilin 1 single amino acid deletion mutation (F175del) with unusual amyloid-β processing effects.

Authors:
Jonathan Vöglein Michael Willem Johannes Trambauer Sonja Schönecker Marianne Dieterich Saskia Biskup Camilla Giudici Kathrin Utz Timo Oberstein Matthias Brendel Axel Rominger Adrian Danek Harald Steiner Christian Haass Johannes Levin

Neurobiol Aging 2019 12 20;84:241.e5-241.e11. Epub 2019 Sep 20.

Department of Neurology, Ludwig-Maximilians-Universität München, Munich, Germany; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany. Electronic address:

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December 2019

Noninvasive 3D Field Mapping of Complex Static Electric Fields.

Authors:
Andreas Kainz Franz Keplinger Wilfried Hortschitz Matthias Kahr Harald Steiner Michael Stifter James R Hunt Javier Resta-Lopez Volodymyr Rodin Carsten P Welsch Jan Borburgh Matthew Alexander Fraser Wolfgang Bartmann

Phys Rev Lett 2019 Jun;122(24):244801

Accelerator Beam Transfer group, CERN, 1211 Geneva, Switzerland.

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June 2019

Comparison of Strategies for the Determination of Sterol Sulfates via GC-MS Leading to a Novel Deconjugation-Derivatization Protocol.

Authors:
Julia Junker Isabelle Chong Frits Kamp Harald Steiner Martin Giera Christoph Müller Franz Bracher

Molecules 2019 Jun 26;24(13). Epub 2019 Jun 26.

Department of Pharmacy-Center for Drug Research, Ludwig-Maximilians University Munich, Butenandtstraße 5-13, 81377 Munich, Germany.

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June 2019

Making the final cut: pathogenic amyloid-β peptide generation by γ-secretase.

Authors:
Harald Steiner Akio Fukumori Shinji Tagami Masayasu Okochi

Cell Stress 2018 Oct 28;2(11):292-310. Epub 2018 Oct 28.

Neuropsychiatry, Department of Integrated Medicine, Division of Internal Medicine, Osaka University Graduate School of Medicine, Suita, Japan.

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October 2018

Modulating Hinge Flexibility in the APP Transmembrane Domain Alters γ-Secretase Cleavage.

Authors:
Alexander Götz Nadine Mylonas Philipp Högel Mara Silber Hannes Heinel Simon Menig Alexander Vogel Hannes Feyrer Daniel Huster Burkhard Luy Dieter Langosch Christina Scharnagl Claudia Muhle-Goll Frits Kamp Harald Steiner

Biophys J 2019 06 3;116(11):2103-2120. Epub 2019 May 3.

Biomedical Center (BMC), Metabolic Biochemistry, Ludwig-Maximilians-University, Munich, Germany; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany. Electronic address:

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June 2019

Clinical, pathophysiological and genetic features of motor symptoms in autosomal dominant Alzheimer's disease.

Authors:
Jonathan Vöglein Katrina Paumier Mathias Jucker Oliver Preische Eric McDade Jason Hassenstab Tammie L Benzinger James M Noble Sarah B Berman Neill R Graff-Radford Bernardino Ghetti Martin R Farlow Jasmeer Chhatwal Stephen Salloway Chengjie Xiong Celeste M Karch Nigel Cairns Hiroshi Mori Peter R Schofield Colin L Masters Alison Goate Virginia Buckles Nick Fox Martin Rossor Patricio Chrem Ricardo Allegri John M Ringman Günter Höglinger Harald Steiner Marianne Dieterich Christian Haass Christoph Laske John C Morris Randall J Bateman Adrian Danek Johannes Levin

Brain 2019 05;142(5):1429-1440

German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.

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May 2019

A Thermal Flow Sensor Based on Printed Circuit Technology in Constant Temperature Mode for Various Fluids.

Authors:
Thomas Glatzl Roman Beigelbeck Samir Cerimovic Harald Steiner Florian Wenig Thilo Sauter Albert Treytl Franz Keplinger

Sensors (Basel) 2019 Mar 2;19(5). Epub 2019 Mar 2.

Institute of Sensor and Actuator Systems, TU Wien, Gusshausstrasse 27-29, 1040 Vienna, Austria.

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March 2019

Atherogenic LOX-1 signaling is controlled by SPPL2-mediated intramembrane proteolysis.

Authors:
Torben Mentrup Kosta Theodorou Florencia Cabrera-Cabrera Andreas O Helbig Kathrin Happ Marion Gijbels Ann-Christine Gradtke Björn Rabe Akio Fukumori Harald Steiner Andreas Tholey Regina Fluhrer Marjo Donners Bernd Schröder

J Exp Med 2019 04 28;216(4):807-830. Epub 2019 Feb 28.

Institute of Physiological Chemistry, Technische Universität Dresden, Dresden, Germany

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April 2019

Dual Resonator MEMS Magnetic Field Gradiometer.

Authors:
Matthias Kahr Michael Stifter Harald Steiner Wilfried Hortschitz Gabor Kovács Andreas Kainz Johannes Schalko Franz Keplinger

Sensors (Basel) 2019 Jan 25;19(3). Epub 2019 Jan 25.

Institute of Sensor and Actuator Systems, TU Wien, 1040 Vienna, Austria.

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January 2019

Bexarotene Binds to the Amyloid Precursor Protein Transmembrane Domain, Alters Its α-Helical Conformation, and Inhibits γ-Secretase Nonselectively in Liposomes.

Authors:
Frits Kamp Holger A Scheidt Edith Winkler Gabriele Basset Hannes Heinel James M Hutchison Loren M LaPointe Charles R Sanders Harald Steiner Daniel Huster

ACS Chem Neurosci 2018 07 11;9(7):1702-1713. Epub 2018 May 11.

Institute for Medical Physics and Biophysics , Leipzig University , Härtelstr. 16-18 , D-04107 Leipzig , Germany.

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July 2018

A high-content screen for small-molecule regulators of epithelial cell-adhesion molecule (EpCAM) cleavage yields a robust inhibitor.

Authors:
Jana Ylva Tretter Kenji Schorpp Elke Luxenburger Johannes Trambauer Harald Steiner Kamyar Hadian Olivier Gires Dierk Niessing

J Biol Chem 2018 06 26;293(23):8994-9005. Epub 2018 Apr 26.

From the Institute of Structural Biology and

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June 2018

Distortion-free measurement of electric field strength with a MEMS sensor.

Authors:
Andreas Kainz Harald Steiner Johannes Schalko Artur Jachimowicz Franz Kohl Michael Stifter Roman Beigelbeck Franz Keplinger Wilfried Hortschitz

Nat Electron 2018 Jan;1:68-73

Center of Integrated Sensor Systems, Danube University Krems, Wr. Neustadt, Austria.

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January 2018

An Alzheimer-associated TREM2 variant occurs at the ADAM cleavage site and affects shedding and phagocytic function.

Authors:
Kai Schlepckow Gernot Kleinberger Akio Fukumori Regina Feederle Stefan F Lichtenthaler Harald Steiner Christian Haass

EMBO Mol Med 2017 10;9(10):1356-1365

Biomedical Center (BMC), Biochemistry, Ludwig-Maximilians-Universität München, Munich, Germany

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October 2017

Substrate processing in intramembrane proteolysis by γ-secretase - the role of protein dynamics.

Authors:
Dieter Langosch Harald Steiner

Biol Chem 2017 04;398(4):441-453

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April 2017