Harald Steiner

Harald Steiner

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Harald Steiner

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Identification of a rare presenilin 1 single amino acid deletion mutation (F175del) with unusual amyloid-β processing effects.

Authors:
Jonathan Vöglein Michael Willem Johannes Trambauer Sonja Schönecker Marianne Dieterich Saskia Biskup Camilla Giudici Kathrin Utz Timo Oberstein Matthias Brendel Axel Rominger Adrian Danek Harald Steiner Christian Haass Johannes Levin

Neurobiol Aging 2019 Sep 20. Epub 2019 Sep 20.

Department of Neurology, Ludwig-Maximilians-Universität München, Munich, Germany; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2019.08.034DOI Listing
September 2019

Modulating Hinge Flexibility in the APP Transmembrane Domain Alters γ-Secretase Cleavage.

Authors:
Alexander Götz Nadine Mylonas Philipp Högel Mara Silber Hannes Heinel Simon Menig Alexander Vogel Hannes Feyrer Daniel Huster Burkhard Luy Dieter Langosch Christina Scharnagl Claudia Muhle-Goll Frits Kamp Harald Steiner

Biophys J 2019 Jun 3;116(11):2103-2120. Epub 2019 May 3.

Biomedical Center (BMC), Metabolic Biochemistry, Ludwig-Maximilians-University, Munich, Germany; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00063495193037
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http://dx.doi.org/10.1016/j.bpj.2019.04.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6554489PMC
June 2019

Comparison of Strategies for the Determination of Sterol Sulfates via GC-MS Leading to a Novel Deconjugation-Derivatization Protocol.

Authors:
Julia Junker Isabelle Chong Frits Kamp Harald Steiner Martin Giera Christoph Müller Franz Bracher

Molecules 2019 Jun 26;24(13). Epub 2019 Jun 26.

Department of Pharmacy-Center for Drug Research, Ludwig-Maximilians University Munich, Butenandtstraße 5-13, 81377 Munich, Germany.

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http://dx.doi.org/10.3390/molecules24132353DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6651411PMC
June 2019

Noninvasive 3D Field Mapping of Complex Static Electric Fields.

Authors:
Andreas Kainz Franz Keplinger Wilfried Hortschitz Matthias Kahr Harald Steiner Michael Stifter James R Hunt Javier Resta-Lopez Volodymyr Rodin Carsten P Welsch Jan Borburgh Matthew Alexander Fraser Wolfgang Bartmann

Phys Rev Lett 2019 Jun;122(24):244801

Accelerator Beam Transfer group, CERN, 1211 Geneva, Switzerland.

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http://dx.doi.org/10.1103/PhysRevLett.122.244801DOI Listing
June 2019

Clinical, pathophysiological and genetic features of motor symptoms in autosomal dominant Alzheimer's disease.

Authors:
Jonathan Vöglein Katrina Paumier Mathias Jucker Oliver Preische Eric McDade Jason Hassenstab Tammie L Benzinger James M Noble Sarah B Berman Neill R Graff-Radford Bernardino Ghetti Martin R Farlow Jasmeer Chhatwal Stephen Salloway Chengjie Xiong Celeste M Karch Nigel Cairns Hiroshi Mori Peter R Schofield Colin L Masters Alison Goate Virginia Buckles Nick Fox Martin Rossor Patricio Chrem Ricardo Allegri John M Ringman Günter Höglinger Harald Steiner Marianne Dieterich Christian Haass Christoph Laske John C Morris Randall J Bateman Adrian Danek Johannes Levin

Brain 2019 May;142(5):1429-1440

German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.

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http://dx.doi.org/10.1093/brain/awz050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6735903PMC
May 2019

Atherogenic LOX-1 signaling is controlled by SPPL2-mediated intramembrane proteolysis.

Authors:
Torben Mentrup Kosta Theodorou Florencia Cabrera-Cabrera Andreas O Helbig Kathrin Happ Marion Gijbels Ann-Christine Gradtke Björn Rabe Akio Fukumori Harald Steiner Andreas Tholey Regina Fluhrer Marjo Donners Bernd Schröder

J Exp Med 2019 Apr 28;216(4):807-830. Epub 2019 Feb 28.

Institute of Physiological Chemistry, Technische Universität Dresden, Dresden, Germany

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http://dx.doi.org/10.1084/jem.20171438DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446863PMC
April 2019

A Thermal Flow Sensor Based on Printed Circuit Technology in Constant Temperature Mode for Various Fluids.

Authors:
Thomas Glatzl Roman Beigelbeck Samir Cerimovic Harald Steiner Florian Wenig Thilo Sauter Albert Treytl Franz Keplinger

Sensors (Basel) 2019 Mar 2;19(5). Epub 2019 Mar 2.

Institute of Sensor and Actuator Systems, TU Wien, Gusshausstrasse 27-29, 1040 Vienna, Austria.

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https://www.mdpi.com/1424-8220/19/5/1065
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http://dx.doi.org/10.3390/s19051065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6427538PMC
March 2019

Dual Resonator MEMS Magnetic Field Gradiometer.

Authors:
Matthias Kahr Michael Stifter Harald Steiner Wilfried Hortschitz Gabor Kovács Andreas Kainz Johannes Schalko Franz Keplinger

Sensors (Basel) 2019 Jan 25;19(3). Epub 2019 Jan 25.

Institute of Sensor and Actuator Systems, TU Wien, 1040 Vienna, Austria.

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http://dx.doi.org/10.3390/s19030493DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6387345PMC
January 2019

Making the final cut: pathogenic amyloid-β peptide generation by γ-secretase.

Authors:
Harald Steiner Akio Fukumori Shinji Tagami Masayasu Okochi

Cell Stress 2018 Oct 28;2(11):292-310. Epub 2018 Oct 28.

Neuropsychiatry, Department of Integrated Medicine, Division of Internal Medicine, Osaka University Graduate School of Medicine, Suita, Japan.

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http://dx.doi.org/10.15698/cst2018.11.162DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6551803PMC
October 2018

Bexarotene Binds to the Amyloid Precursor Protein Transmembrane Domain, Alters Its α-Helical Conformation, and Inhibits γ-Secretase Nonselectively in Liposomes.

Authors:
Frits Kamp Holger A Scheidt Edith Winkler Gabriele Basset Hannes Heinel James M Hutchison Loren M LaPointe Charles R Sanders Harald Steiner Daniel Huster

ACS Chem Neurosci 2018 07 11;9(7):1702-1713. Epub 2018 May 11.

Institute for Medical Physics and Biophysics , Leipzig University , Härtelstr. 16-18 , D-04107 Leipzig , Germany.

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http://pubs.acs.org/doi/10.1021/acschemneuro.8b00068
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http://dx.doi.org/10.1021/acschemneuro.8b00068DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6051911PMC
July 2018

A high-content screen for small-molecule regulators of epithelial cell-adhesion molecule (EpCAM) cleavage yields a robust inhibitor.

Authors:
Jana Ylva Tretter Kenji Schorpp Elke Luxenburger Johannes Trambauer Harald Steiner Kamyar Hadian Olivier Gires Dierk Niessing

J Biol Chem 2018 06 26;293(23):8994-9005. Epub 2018 Apr 26.

From the Institute of Structural Biology and

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http://dx.doi.org/10.1074/jbc.RA118.002776DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5995519PMC
June 2018

Distortion-free measurement of electric field strength with a MEMS sensor.

Authors:
Andreas Kainz Harald Steiner Johannes Schalko Artur Jachimowicz Franz Kohl Michael Stifter Roman Beigelbeck Franz Keplinger Wilfried Hortschitz

Nat Electron 2018 Jan;1:68-73

Center of Integrated Sensor Systems, Danube University Krems, Wr. Neustadt, Austria.

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http://dx.doi.org/10.1038/s41928-017-0009-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5824978PMC
January 2018

An Alzheimer-associated TREM2 variant occurs at the ADAM cleavage site and affects shedding and phagocytic function.

Authors:
Kai Schlepckow Gernot Kleinberger Akio Fukumori Regina Feederle Stefan F Lichtenthaler Harald Steiner Christian Haass

EMBO Mol Med 2017 10;9(10):1356-1365

Biomedical Center (BMC), Biochemistry, Ludwig-Maximilians-Universität München, Munich, Germany

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http://dx.doi.org/10.15252/emmm.201707672DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5623859PMC
October 2017

Substrate processing in intramembrane proteolysis by γ-secretase - the role of protein dynamics.

Authors:
Dieter Langosch Harald Steiner

Biol Chem 2017 04;398(4):441-453

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http://dx.doi.org/10.1515/hsz-2016-0269DOI Listing
April 2017

Substrate recruitment of γ-secretase and mechanism of clinical presenilin mutations revealed by photoaffinity mapping.

Authors:
Akio Fukumori Harald Steiner

EMBO J 2016 08 23;35(15):1628-43. Epub 2016 May 23.

Biomedical Center (BMC), Metabolic Biochemistry, Ludwig-Maximilians-University Munich, Munich, Germany German Center for Neurodegenerative Diseases (DZNE), Munich, Germany

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http://dx.doi.org/10.15252/embj.201694151DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4883025PMC
August 2016

Substrate determinants of signal peptide peptidase-like 2a (SPPL2a)-mediated intramembrane proteolysis of the invariant chain CD74.

Authors:
Susann Hüttl Felix Helfrich Torben Mentrup Sebastian Held Akio Fukumori Harald Steiner Paul Saftig Regina Fluhrer Bernd Schröder

Biochem J 2016 05 17;473(10):1405-22. Epub 2016 Mar 17.

Biochemical Institute, Christian Albrechts University of Kiel, Otto-Hahn-Platz 9, D-24118 Kiel, Germany

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http://www.biochemj.org/content/ppbiochemj/early/2016/03/17/
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http://biochemj.org/cgi/doi/10.1042/BCJ20160156
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http://dx.doi.org/10.1042/BCJ20160156DOI Listing
May 2016

Generation and deposition of Aβ43 by the virtually inactive presenilin-1 L435F mutant contradicts the presenilin loss-of-function hypothesis of Alzheimer's disease.

Authors:
Benedikt Kretner Johannes Trambauer Akio Fukumori Janina Mielke Peer-Hendrik Kuhn Elisabeth Kremmer Armin Giese Stefan F Lichtenthaler Christian Haass Thomas Arzberger Harald Steiner

EMBO Mol Med 2016 05 2;8(5):458-65. Epub 2016 May 2.

Biomedical Center, Metabolic Biochemistry, Ludwig-Maximilians-University Munich, Munich, Germany DZNE - German Center for Neurodegenerative Diseases, Munich, Germany

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http://dx.doi.org/10.15252/emmm.201505952DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5119496PMC
May 2016

Proteolytic Processing of Neuregulin 1 Type III by Three Intramembrane-cleaving Proteases.

Authors:
Daniel Fleck Matthias Voss Ben Brankatschk Camilla Giudici Heike Hampel Benjamin Schwenk Dieter Edbauer Akio Fukumori Harald Steiner Elisabeth Kremmer Martina Haug-Kröper Moritz J Rossner Regina Fluhrer Michael Willem Christian Haass

J Biol Chem 2016 Jan 16;291(1):318-33. Epub 2015 Nov 16.

From the Biomedical Center, Biochemistry, Ludwig-Maximilians-University Munich, 81377 Munich, the German Center for Neurodegenerative Diseases (DZNE), Munich, 81377 Munich, the Munich Cluster for Systems Neurology (SyNergy), 81377 Munich, and

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http://www.jbc.org/content/291/1/318.full.pdf
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http://www.jbc.org/lookup/doi/10.1074/jbc.M115.697995
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http://dx.doi.org/10.1074/jbc.M115.697995DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4697167PMC
January 2016

Cleavage and cell adhesion properties of human epithelial cell adhesion molecule (HEPCAM).

Authors:
Thanos Tsaktanis Heidi Kremling Miha Pavšič Ricarda von Stackelberg Brigitte Mack Akio Fukumori Harald Steiner Franziska Vielmuth Volker Spindler Zhe Huang Jasmine Jakubowski Nikolas H Stoecklein Elke Luxenburger Kirsten Lauber Brigita Lenarčič Olivier Gires

J Biol Chem 2016 Jan;291(1):425

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http://www.jbc.org/content/early/2015/08/19/jbc.M115.662700.
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http://www.jbc.org/content/290/40/24574.full.pdf
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http://www.jbc.org/lookup/doi/10.1074/jbc.A115.662700
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http://dx.doi.org/10.1074/jbc.A115.662700DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4697179PMC
January 2016

Cross-sectional comparison of small animal [18F]-florbetaben amyloid-PET between transgenic AD mouse models.

Authors:
Matthias Brendel Anna Jaworska Eric Grießinger Christina Rötzer Steffen Burgold Franz-Josef Gildehaus Janette Carlsen Paul Cumming Karlheinz Baumann Christian Haass Harald Steiner Peter Bartenstein Jochen Herms Axel Rominger

PLoS One 2015 23;10(2):e0116678. Epub 2015 Feb 23.

Dept. of Nuclear Medicine, University of Munich, Munich, Germany; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0116678PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4338066PMC
December 2015

Cleavage and cell adhesion properties of human epithelial cell adhesion molecule (HEPCAM).

Authors:
Thanos Tsaktanis Heidi Kremling Miha Pavšič Ricarda von Stackelberg Brigitte Mack Akio Fukumori Harald Steiner Franziska Vielmuth Volker Spindler Zhe Huang Jasmine Jakubowski Nikolas H Stoecklein Elke Luxenburger Kirsten Lauber Brigita Lenarčič Olivier Gires

J Biol Chem 2015 Oct 19;290(40):24574-91. Epub 2015 Aug 19.

From the Department of Otorhinolaryngology, Head and Neck Surgery, Grosshadern Medical Center,

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http://dx.doi.org/10.1074/jbc.M115.662700DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4591836PMC
October 2015

Homodimerization Protects the Amyloid Precursor Protein C99 Fragment from Cleavage by γ-Secretase.

Authors:
Edith Winkler Ayse Julius Harald Steiner Dieter Langosch

Biochemistry 2015 Oct 29;54(40):6149-52. Epub 2015 Sep 29.

Lehrstuhl Chemie der Biopolymere, Technische Universität München , Weihenstephaner Berg 3, 85354 Freising, Germany.

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http://dx.doi.org/10.1021/acs.biochem.5b00986DOI Listing
October 2015

Inhibition of amyloid-β plaque formation by α-synuclein.

Authors:
Teresa Bachhuber Natalie Katzmarski Joanna F McCarter Desiree Loreth Sabina Tahirovic Frits Kamp Claudia Abou-Ajram Brigitte Nuscher Alberto Serrano-Pozo Alexandra Müller Marco Prinz Harald Steiner Bradley T Hyman Christian Haass Melanie Meyer-Luehmann

Nat Med 2015 Jul 22;21(7):802-7. Epub 2015 Jun 22.

1] Adolf Butenandt Institute, Department of Biochemistry, Ludwig-Maximilians University, Munich, Germany. [2] Neurocenter, Department of Neurology, University of Freiburg, Freiburg, Germany.

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http://dx.doi.org/10.1038/nm.3885DOI Listing
July 2015

Intramembrane proteolysis of β-amyloid precursor protein by γ-secretase is an unusually slow process.

Authors:
Frits Kamp Edith Winkler Johannes Trambauer Amelie Ebke Regina Fluhrer Harald Steiner

Biophys J 2015 Mar;108(5):1229-37

Metabolic Biochemistry, Ludwig-Maximilians-University, München, Germany; DZNE-German Center for Neurodegenerative Diseases, Munich, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.bpj.2014.12.045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4375682PMC
March 2015

Shedding of glycan-modifying enzymes by signal peptide peptidase-like 3 (SPPL3) regulates cellular N-glycosylation.

Authors:
Matthias Voss Ulrike Künzel Fabian Higel Peer-Hendrik Kuhn Alessio Colombo Akio Fukumori Martina Haug-Kröper Bärbel Klier Gudula Grammer Andreas Seidl Bernd Schröder Reinhard Obst Harald Steiner Stefan F Lichtenthaler Christian Haass Regina Fluhrer

EMBO J 2014 Dec 29;33(24):2890-905. Epub 2014 Oct 29.

Adolf Butenandt Institute for Biochemistry, Ludwig-Maximilians University Munich, Munich, Germany DZNE - German Center for Neurodegenerative Diseases, Munich, Germany

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http://dx.doi.org/10.15252/embj.201488375DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4282638PMC
December 2014

The yeast ER-intramembrane protease Ypf1 refines nutrient sensing by regulating transporter abundance.

Authors:
Dönem Avci Shai Fuchs Bianca Schrul Akio Fukumori Michal Breker Idan Frumkin Chia-Yi Chen Martin L Biniossek Elisabeth Kremmer Oliver Schilling Harald Steiner Maya Schuldiner Marius K Lemberg

Mol Cell 2014 Dec 13;56(5):630-40. Epub 2014 Nov 13.

Zentrum für Molekulare Biologie der Universität Heidelberg (ZMBH), DKFZ-ZMBH Allianz, Im Neuenheimer Feld 282, 69120 Heidelberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2014.10.012DOI Listing
December 2014

Regulated intramembrane proteolysis and degradation of murine epithelial cell adhesion molecule mEpCAM.

Authors:
Matthias Hachmeister Karolina D Bobowski Sebastian Hogl Bastian Dislich Akio Fukumori Carola Eggert Brigitte Mack Heidi Kremling Sannia Sarrach Fabian Coscia Wolfgang Zimmermann Harald Steiner Stefan F Lichtenthaler Olivier Gires

PLoS One 2013 29;8(8):e71836. Epub 2013 Aug 29.

Department of Otorhinolaryngology, Head and Neck Surgery, Ludwig-Maximilians-University, Munich, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0071836PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3756971PMC
April 2014

Impact of partial volume effect correction on cerebral β-amyloid imaging in APP-Swe mice using [(18)F]-florbetaben PET.

Authors:
Matthias Brendel Andreas Delker Christina Rötzer Guido Böning Janette Carlsen Clemens Cyran Erik Mille Franz Josef Gildehaus Paul Cumming Karlheinz Baumann Harald Steiner Christian Haass Jochen Herms Peter Bartenstein Axel Rominger

Neuroimage 2014 Jan 20;84:843-53. Epub 2013 Sep 20.

Department of Nuclear Medicine, Ludwig-Maximilians-University, Munich, Germany.

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http://dx.doi.org/10.1016/j.neuroimage.2013.09.017DOI Listing
January 2014

Longitudinal assessment of cerebral β-amyloid deposition in mice overexpressing Swedish mutant β-amyloid precursor protein using 18F-florbetaben PET.

Authors:
Axel Rominger Matthias Brendel Steffen Burgold Kevin Keppler Karlheinz Baumann Guoming Xiong Erik Mille Franz-Josef Gildehaus Janette Carlsen Juli Schlichtiger Sabrina Niedermoser Björn Wängler Paul Cumming Harald Steiner Jochen Herms Christian Haass Peter Bartenstein

J Nucl Med 2013 Jul 31;54(7):1127-34. Epub 2013 May 31.

Department of Nuclear Medicine, Ludwig-Maximilians-University of Munich, Munich, Germany.

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http://dx.doi.org/10.2967/jnumed.112.114660DOI Listing
July 2013

Important functional role of residue x of the presenilin GxGD protease active site motif for APP substrate cleavage specificity and substrate selectivity of γ-secretase.

Authors:
Benedikt Kretner Akio Fukumori Peer-Hendrik Kuhn Blanca Isabel Pérez-Revuelta Stefan F Lichtenthaler Christian Haass Harald Steiner

J Neurochem 2013 Apr 15;125(1):144-56. Epub 2013 Jan 15.

Adolf-Butenandt-Institute, Biochemistry, Ludwig-Maximilians-University, Munich, Germany.

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http://dx.doi.org/10.1111/jnc.12124DOI Listing
April 2013

Foamy virus envelope protein is a substrate for signal peptide peptidase-like 3 (SPPL3).

Authors:
Matthias Voss Akio Fukumori Peer-Hendrik Kuhn Ulrike Künzel Bärbel Klier Gudula Grammer Martina Haug-Kröper Elisabeth Kremmer Stefan F Lichtenthaler Harald Steiner Bernd Schröder Christian Haass Regina Fluhrer

J Biol Chem 2012 Dec 6;287(52):43401-9. Epub 2012 Nov 6.

Adolf Butenandt Institute for Biochemistry, Ludwig-Maximilians University Munich, 80336 Munich, Germany.

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http://dx.doi.org/10.1074/jbc.M112.371369DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3527927PMC
December 2012

Loss of PAFAH1B2 reduces amyloid-β generation by promoting the degradation of amyloid precursor protein C-terminal fragments.

Authors:
Richard M Page Anna Münch Thomas Horn Peer-Hendrik Kuhn Alessio Colombo Orly Reiner Michael Boutros Harald Steiner Stefan F Lichtenthaler Christian Haass

J Neurosci 2012 Dec;32(50):18204-14

Adolf Butenandt Institute, Biochemistry, Ludwig Maximilians University, 80336 Munich, Germany.

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http://dx.doi.org/10.1523/JNEUROSCI.2681-12.2012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6621731PMC
December 2012

Generation of Alzheimer disease-associated amyloid β42/43 peptide by γ-secretase can be inhibited directly by modulation of membrane thickness.

Authors:
Edith Winkler Frits Kamp Johannes Scheuring Amelie Ebke Akio Fukumori Harald Steiner

J Biol Chem 2012 Jun 24;287(25):21326-34. Epub 2012 Apr 24.

Adolf Butenandt Institute, Biochemistry, Ludwig Maximilians University Munich, Schillerstrasse 44, 80336 Munich, Germany.

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http://dx.doi.org/10.1074/jbc.M112.356659DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3375553PMC
June 2012

The Nicastrin ectodomain adopts a highly thermostable structure.

Authors:
Regina Fluhrer Frits Kamp Gudula Grammer Brigitte Nuscher Harald Steiner Klaus Beyer Christian Haass

Biol Chem 2011 Nov;392(11):995-1001

Adolf-Butenandt-Institute, Biochemistry, Ludwig Maximilians University, Schillerstrasse 44, 80336 Munich, Germany.

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http://dx.doi.org/10.1515/BC.2011.169DOI Listing
November 2011

Novel γ-secretase enzyme modulators directly target presenilin protein.

Authors:
Amelie Ebke Thomas Luebbers Akio Fukumori Keiro Shirotani Christian Haass Karlheinz Baumann Harald Steiner

J Biol Chem 2011 Oct 6;286(43):37181-6. Epub 2011 Sep 6.

Adolf-Butenandt-Institute, Biochemistry, Ludwig-Maximilians-University, 80336 Munich, Germany.

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http://dx.doi.org/10.1074/jbc.C111.276972DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3199465PMC
October 2011

Regulated intramembrane proteolysis--lessons from amyloid precursor protein processing.

Authors:
Stefan F Lichtenthaler Christian Haass Harald Steiner

J Neurochem 2011 Jun 14;117(5):779-96. Epub 2011 Apr 14.

DZNE-German Center for Neurodegenerative Diseases, Adolf-Butenandt-Institute, Biochemistry, Ludwig-Maximilians-University, Munich, Germany.

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http://dx.doi.org/10.1111/j.1471-4159.2011.07248.xDOI Listing
June 2011

Attenuated Abeta42 responses to low potency gamma-secretase modulators can be overcome for many pathogenic presenilin mutants by second-generation compounds.

Authors:
Benedikt Kretner Akio Fukumori Amelie Gutsmiedl Richard M Page Thomas Luebbers Guido Galley Karlheinz Baumann Christian Haass Harald Steiner

J Biol Chem 2011 Apr 25;286(17):15240-51. Epub 2011 Feb 25.

DZNE-German Center for Neurodegenerative Diseases, Ludwig-Maximilians-University, 80336 Munich, Germany.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M110.213587
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http://dx.doi.org/10.1074/jbc.M110.213587DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3083200PMC
April 2011

Beta-amyloid precursor protein mutants respond to gamma-secretase modulators.

Authors:
Richard M Page Amelie Gutsmiedl Akio Fukumori Edith Winkler Christian Haass Harald Steiner

J Biol Chem 2010 Jun 26;285(23):17798-810. Epub 2010 Mar 26.

German Center for Neurodegenerative Diseases DZNE)and Adolf-Butenandt-Institute, Biochemistry, Ludwig-Maximilians-University, 80336 Munich, Germany.

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http://dx.doi.org/10.1074/jbc.M110.103283DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2878544PMC
June 2010

Three-amino acid spacing of presenilin endoproteolysis suggests a general stepwise cleavage of gamma-secretase-mediated intramembrane proteolysis.

Authors:
Akio Fukumori Regina Fluhrer Harald Steiner Christian Haass

J Neurosci 2010 Jun;30(23):7853-62

German Center for Neurodegenerative Diseases, Munich, Germany.

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http://dx.doi.org/10.1523/JNEUROSCI.1443-10.2010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6632680PMC
June 2010

Bepridil and amiodarone simultaneously target the Alzheimer's disease beta- and gamma-secretase via distinct mechanisms.

Authors:
Stefan Mitterreiter Richard M Page Frits Kamp Jessika Hopson Edith Winkler Huy-Riem Ha Runa Hamid Jochen Herms Thomas U Mayer Deborah J Nelson Harald Steiner Tobias Stahl Ulrike Zeitschel Steffen Rossner Christian Haass Stefan F Lichtenthaler

J Neurosci 2010 Jun;30(26):8974-83

German Center for Neurodegenerative Diseases Munich and Adolf Butenandt-Institute, Biochemistry, University of Munich, 80336 Munich, Germany.

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http://dx.doi.org/10.1523/JNEUROSCI.1199-10.2010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6632893PMC
June 2010

Inhibition of gamma-secretase by the CK1 inhibitor IC261 does not depend on CK1delta.

Authors:
Nicole Höttecke Miriam Liebeck Karlheinz Baumann Robert Schubenel Edith Winkler Harald Steiner Boris Schmidt

Bioorg Med Chem Lett 2010 May 4;20(9):2958-63. Epub 2010 Mar 4.

Clemens Schöpf-Institute of Chemistry and Biochemistry, Technische Universität Darmstadt, Petersenstr. 22, D-64287 Darmstadt, Germany.

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http://dx.doi.org/10.1016/j.bmcl.2010.02.110DOI Listing
May 2010

Requirement for small side chain residues within the GxGD-motif of presenilin for gamma-secretase substrate cleavage.

Authors:
Blanca Isabel Pérez-Revuelta Akio Fukumori Sven Lammich Aya Yamasaki Christian Haass Harald Steiner

J Neurochem 2010 Feb 15;112(4):940-50. Epub 2009 Dec 15.

Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE) and Adolf-Butenandt-Institute, Biochemistry, Ludwig-Maximilians-University, München, Germany.

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http://dx.doi.org/10.1111/j.1471-4159.2009.06510.xDOI Listing
February 2010

Gamma-secretase inhibition reduces spine density in vivo via an amyloid precursor protein-dependent pathway.

Authors:
Tobias Bittner Martin Fuhrmann Steffen Burgold Christian K E Jung Christiane Volbracht Harald Steiner Gerda Mitteregger Hans A Kretzschmar Christian Haass Jochen Herms

J Neurosci 2009 Aug;29(33):10405-9

Center of Neuropathology and Prion Research, Ludwig-Maximilians-Universität, Munich, Germany.

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http://dx.doi.org/10.1523/JNEUROSCI.2288-09.2009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6665795PMC
August 2009

The 28-amino acid form of an APLP1-derived Abeta-like peptide is a surrogate marker for Abeta42 production in the central nervous system.

Authors:
Kanta Yanagida Masayasu Okochi Shinji Tagami Taisuke Nakayama Takashi S Kodama Kouhei Nishitomi Jingwei Jiang Kohji Mori Shin-Ichi Tatsumi Tetsuaki Arai Takeshi Ikeuchi Kensaku Kasuga Takahiko Tokuda Masaki Kondo Masaki Ikeda Kentaro Deguchi Hiroaki Kazui Toshihisa Tanaka Takashi Morihara Ryota Hashimoto Takashi Kudo Harald Steiner Christian Haass Kuniaki Tsuchiya Haruhiko Akiyama Ryozo Kuwano Masatoshi Takeda

EMBO Mol Med 2009 Jul;1(4):223-35

Psychiatry, Department of Integrated Medicine, Division of Internal Medicine, Osaka University Graduate School of Medicine, Osaka 565-0871, Japan.

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http://dx.doi.org/10.1002/emmm.200900026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3378133PMC
July 2009

Intramembrane proteolysis by signal peptide peptidases: a comparative discussion of GXGD-type aspartyl proteases.

Authors:
Regina Fluhrer Harald Steiner Christian Haass

J Biol Chem 2009 May 3;284(21):13975-9. Epub 2009 Feb 3.

Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE) and Adolf Butenandt Institute, Biochemistry, Ludwig-Maximilians University, Munich, 80336 Munich, Germany.

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http://dx.doi.org/10.1074/jbc.R800040200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2682845PMC
May 2009

Purification, pharmacological modulation, and biochemical characterization of interactors of endogenous human gamma-secretase.

Authors:
Edith Winkler Scott Hobson Akio Fukumori Birgit Dümpelfeld Thomas Luebbers Karlheinz Baumann Christian Haass Carsten Hopf Harald Steiner

Biochemistry 2009 Feb;48(6):1183-97

Center for Integrated Protein Science Munich and Adolf-Butenandt-Institute, Department of Biochemistry, Laboratory for Neurodegenerative Disease Research, Ludwig-Maximilians-University, 80336 Munich, Germany.

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http://pubs.acs.org/doi/abs/10.1021/bi801204g
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February 2009

Chemical cross-linking provides a model of the gamma-secretase complex subunit architecture and evidence for close proximity of the C-terminal fragment of presenilin with APH-1.

Authors:
Harald Steiner Edith Winkler Christian Haass

J Biol Chem 2008 Dec 18;283(50):34677-86. Epub 2008 Sep 18.

Center for Integrated Protein Science Munich and Adolf-Butenandt-Institute, Department of Biochemistry, Laboratory for Neurodegenerative Disease Research, Ludwig-Maximilians-University, 80336 Munich, Germany.

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http://dx.doi.org/10.1074/jbc.M709067200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3259863PMC
December 2008

Intramembrane proteolysis by gamma-secretase.

Authors:
Harald Steiner Regina Fluhrer Christian Haass

J Biol Chem 2008 Oct 23;283(44):29627-31. Epub 2008 Jul 23.

Center for Integrated Protein Science Munich and Adolf Butenandt Institute, Department of Biochemistry, Laboratory for Neurodegenerative Disease Research, Ludwig Maximilians University, 80336 Munich, Germany.

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http://dx.doi.org/10.1074/jbc.R800010200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2662049PMC
October 2008

Intramembrane proteolysis of GXGD-type aspartyl proteases is slowed by a familial Alzheimer disease-like mutation.

Authors:
Regina Fluhrer Akio Fukumori Lucas Martin Gudula Grammer Martina Haug-Kröper Bärbel Klier Edith Winkler Elisabeth Kremmer Margaret M Condron David B Teplow Harald Steiner Christian Haass

J Biol Chem 2008 Oct 3;283(44):30121-8. Epub 2008 Sep 3.

Center for Integrated Protein Science Munich and Adolf-Butenandt-Institute, Department of Biochemistry, Laboratory for Neurodegenerative Disease Research, Ludwig-Maximilians-University, Munich 80336, Germany.

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http://dx.doi.org/10.1074/jbc.M806092200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2573083PMC
October 2008

The catalytic core of gamma-secretase: presenilin revisited.

Authors:
Harald Steiner

Curr Alzheimer Res 2008 Apr;5(2):147-57

Adolf-Butenandt-Institute, Department of Biochemistry, Laboratory for Neurodegenerative Disease Research, Schil-lerstr. 44, Ludwig-Maximilians-University, 80336 Munich, Germany.

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April 2008

Generation of Abeta38 and Abeta42 is independently and differentially affected by familial Alzheimer disease-associated presenilin mutations and gamma-secretase modulation.

Authors:
Richard M Page Karlheinz Baumann Masanori Tomioka Blanca I Pérez-Revuelta Akio Fukumori Helmut Jacobsen Alexander Flohr Thomas Luebbers Laurence Ozmen Harald Steiner Christian Haass

J Biol Chem 2008 Jan 24;283(2):677-83. Epub 2007 Oct 24.

Center for Integrated Protein Science Munich and Adolf Butenandt Institute, Department of Biochemistry, Laboratory for Neurodegenerative Disease Research, Ludwig Maximilians University, 80336 Munich, Germany.

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http://dx.doi.org/10.1074/jbc.M708754200DOI Listing
January 2008

Active gamma-secretase complexes contain only one of each component.

Authors:
Toru Sato Thekla S Diehl Saravanakumar Narayanan Satoru Funamoto Yasuo Ihara Bart De Strooper Harald Steiner Christian Haass Michael S Wolfe

J Biol Chem 2007 Nov 2;282(47):33985-93. Epub 2007 Oct 2.

Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1074/jbc.M705248200DOI Listing
November 2007

Endoplasmic reticulum retention of the gamma-secretase complex component Pen2 by Rer1.

Authors:
Christoph Kaether Johanna Scheuermann Matthias Fassler Sonja Zilow Keiro Shirotani Christina Valkova Bozidar Novak Slavomir Kacmar Harald Steiner Christian Haass

EMBO Rep 2007 Aug 6;8(8):743-8. Epub 2007 Jul 6.

Laboratory for Alzheimer's and Parkinson's Disease Research, Department of Biochemistry, Center For Integrated Protein Science Munich and Adolf-Butenandt-Institute, Ludwig-Maximilians-Universität, München 80336, Germany.

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http://dx.doi.org/10.1038/sj.embor.7401027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1978084PMC
August 2007

Pathological activity of familial Alzheimer's disease-associated mutant presenilin can be executed by six different gamma-secretase complexes.

Authors:
Keiro Shirotani Masanori Tomioka Elisabeth Kremmer Christian Haass Harald Steiner

Neurobiol Dis 2007 Jul 6;27(1):102-7. Epub 2007 May 6.

Munich Center for Integrated Protein Science and Adolf-Butenandt-Institute, Department of Biochemistry, Laboratory for Alzheimer's and Parkinson's Disease Research, Ludwig-Maximilians-University, Schillerstr 44, Munich, Germany.

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http://dx.doi.org/10.1016/j.nbd.2007.04.011DOI Listing
July 2007

Sheddases and intramembrane-cleaving proteases: RIPpers of the membrane. Symposium on regulated intramembrane proteolysis.

Authors:
Stefan F Lichtenthaler Harald Steiner

EMBO Rep 2007 Jun 11;8(6):537-41. Epub 2007 May 11.

Adolf-Butenandt-Institute, Department of Biochemistry, Laboratory of Alzheimer's and Parkinson's Disease Research, Ludwig-Maximilians-University, Schillerstrasse 44, 80336 Munich, Germany.

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http://dx.doi.org/10.1038/sj.embor.7400978DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2002526PMC
June 2007

N-Substituted carbazolyloxyacetic acids modulate Alzheimer associated gamma-secretase.

Authors:
Rajeshwar Narlawar Blanca I Pérez Revuelta Karlheinz Baumann Robert Schubenel Christian Haass Harald Steiner Boris Schmidt

Bioorg Med Chem Lett 2007 Jan 10;17(1):176-82. Epub 2006 Oct 10.

Clemens Schöpf-Institute of Chemistry and Biochemistry, Darmstadt University of Technology, Petersenstr. 22, D-64287 Darmstadt, Germany.

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http://dx.doi.org/10.1016/j.bmcl.2006.09.061DOI Listing
January 2007

Assembly, trafficking and function of gamma-secretase.

Authors:
Christoph Kaether Christian Haass Harald Steiner

Neurodegener Dis 2006 ;3(4-5):275-83

Laboratory for Alzheimer's and Parkinson's Disease Research, Department of Biochemistry, Adolf Butenandt Institute, Ludwig Maximilians University, Munich, Germany.

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https://www.karger.com/Article/FullText/95267
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http://dx.doi.org/10.1159/000095267DOI Listing
December 2006

Scaffold of the cyclooxygenase-2 (COX-2) inhibitor carprofen provides Alzheimer gamma-secretase modulators.

Authors:
Rajeshwar Narlawar Blanca I Pérez Revuelta Christian Haass Harald Steiner Boris Schmidt Karlheinz Baumann

J Med Chem 2006 Dec;49(26):7588-91

Clemens Schöpf-Institute of Chemistry and Biochemistry, Darmstadt University of Technology, Petersenstrasse 22, D-64287 Darmstadt, Germany.

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http://dx.doi.org/10.1021/jm0610200DOI Listing
December 2006

Pore-forming scissors? A first structural glimpse of gamma-secretase.

Authors:
Harald Steiner Manuel Than Wolfram Bode Christian Haass

Trends Biochem Sci 2006 Sep 4;31(9):491-3. Epub 2006 Aug 4.

Adolf-Butenandt-Institute, Department of Biochemistry, Laboratory for Alzheimer's and Parkinson's Disease Research, Ludwig-Maximilians University, Schillerstrasse 44, 80336 Munich, Germany.

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http://dx.doi.org/10.1016/j.tibs.2006.07.008DOI Listing
September 2006

SorLA signaling by regulated intramembrane proteolysis.

Authors:
Christopher Böhm Nicole M Seibel Birgit Henkel Harald Steiner Christian Haass Wolfgang Hampe

J Biol Chem 2006 May 10;281(21):14547-53. Epub 2006 Mar 10.

University Medical Center Hamburg-Eppendorf, Center of Experimental Medicine, Department of Biochemistry and Molecular Biology II: Molecular Cell Biology, Martinistrasse 52, D-20246 Hamburg, Germany.

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http://dx.doi.org/10.1074/jbc.M601660200DOI Listing
May 2006

The GxGD motif of presenilin contributes to catalytic function and substrate identification of gamma-secretase.

Authors:
Aya Yamasaki Stefan Eimer Masayasu Okochi Agata Smialowska Christoph Kaether Ralf Baumeister Christian Haass Harald Steiner

J Neurosci 2006 Apr;26(14):3821-8

Laboratory for Alzheimer's and Parkinson's Disease Research, Department of Biochemistry, Adolf Butenandt Institute, Ludwig Maximilians University, 80336 Munich, Germany.

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http://dx.doi.org/10.1523/JNEUROSCI.5354-05.2006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6674133PMC
April 2006

Secretion of the Notch-1 Abeta-like peptide during Notch signaling.

Authors:
Masayasu Okochi Akio Fukumori Jingwei Jiang Naohiro Itoh Ryo Kimura Harald Steiner Christian Haass Shinji Tagami Masatoshi Takeda

J Biol Chem 2006 Mar 23;281(12):7890-8. Epub 2006 Jan 23.

Department of Post-Genomics and Diseases, Division of Psychiatry and Behavioral Proteomics, Osaka University Graduate School of Medicine, Osaka 565-0871, Japan.

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http://dx.doi.org/10.1074/jbc.M513250200DOI Listing
March 2006

Differential localization and identification of a critical aspartate suggest non-redundant proteolytic functions of the presenilin homologues SPPL2b and SPPL3.

Authors:
Peter Krawitz Christof Haffner Regina Fluhrer Harald Steiner Bettina Schmid Christian Haass

J Biol Chem 2005 Nov 5;280(47):39515-23. Epub 2005 Jul 5.

Adolf-Butenandt-Institute, Department of Biochemistry, Laboratory for Alzheimer's and Parkinson's Disease Research, Ludwig-Maximilians-University, Schillerstrasse 44, 80336 Munich, Germany.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M501645200
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http://dx.doi.org/10.1074/jbc.M501645200DOI Listing
November 2005

Length and overall sequence of the PEN-2 C-terminal domain determines its function in the stabilization of presenilin fragments.

Authors:
Stefan Prokop Christian Haass Harald Steiner

J Neurochem 2005 Jul;94(1):57-62

Adolf-Butenandt-Institute, Department of Biochemistry, Laboratory for Alzheimer's and Parkinson's Disease Research, Ludwig-Maximilians-University, Munich, Germany.

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http://doi.wiley.com/10.1111/j.1471-4159.2005.03165.x
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http://dx.doi.org/10.1111/j.1471-4159.2005.03165.xDOI Listing
July 2005

Gamma-secretase complex assembly within the early secretory pathway.

Authors:
Anja Capell Dirk Beher Stefan Prokop Harald Steiner Christoph Kaether Mark S Shearman Christian Haass

J Biol Chem 2005 Feb 10;280(8):6471-8. Epub 2004 Dec 10.

Adolf-Butenandt-Institut, Department of Biochemistry, Laboratory for Alzheimer's and Parkinson's Disease Research, Ludwig-Maximilians-Universität, Schillerstrasse 44, 80336 Munich, Germany.

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http://dx.doi.org/10.1074/jbc.M409106200DOI Listing
February 2005

The presenilin C-terminus is required for ER-retention, nicastrin-binding and gamma-secretase activity.

Authors:
Christoph Kaether Anja Capell Dieter Edbauer Edith Winkler Bozidar Novak Harald Steiner Christian Haass

EMBO J 2004 Dec 18;23(24):4738-48. Epub 2004 Nov 18.

Laboratory for Alzheimer's and Parkinson's Disease Research, Department of Biochemistry, Adolf-Butenandt-Institute, Ludwig-Maximilians-Universität, München, Germany.

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http://dx.doi.org/10.1038/sj.emboj.7600478DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC535090PMC
December 2004

Identification of distinct gamma-secretase complexes with different APH-1 variants.

Authors:
Keiro Shirotani Dieter Edbauer Stefan Prokop Christian Haass Harald Steiner

J Biol Chem 2004 Oct 30;279(40):41340-5. Epub 2004 Jul 30.

Adolf-Butenandt-Institute, Department of Biochemistry, Laboratory for Alzheimer's and Parkinson's Disease Research, Schillerstrasse 44, Ludwig-Maximilians-University, 80336 Munich, Germany.

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http://dx.doi.org/10.1074/jbc.M405768200DOI Listing
October 2004

Co-expression of nicastrin and presenilin rescues a loss of function mutant of APH-1.

Authors:
Dieter Edbauer Christoph Kaether Harald Steiner Christian Haass

J Biol Chem 2004 Sep 21;279(36):37311-5. Epub 2004 Jun 21.

Adolf-Butenandt-Institute, Department of Biochemistry, Laboratory for Alzheimer's and Parkinson's Disease Research, Schillerstr. 44, Ludwig-Maximilians-University, 80336 Munich, Germany.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M406228200
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September 2004

Uncovering gamma-secretase.

Authors:
Harald Steiner

Curr Alzheimer Res 2004 Aug;1(3):175-81

Adolf-Butenandt-Institute, Department of Biochemistry, Laboratory for Alzheimer's and Parkinson's Disease Research, Schillerstrasse 44, Ludwig-Maximilians-University, 80336 Munich, Germany.

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August 2004

Immature nicastrin stabilizes APH-1 independent of PEN-2 and presenilin: identification of nicastrin mutants that selectively interact with APH-1.

Authors:
Keiro Shirotani Dieter Edbauer Marcus Kostka Harald Steiner Christian Haass

J Neurochem 2004 Jun;89(6):1520-7

Adolf-Butenandt Institute, Department of Biochemistry, Laboratory for Alzheimer's and Parkinson's Disease Research, Ludwig-Maximilians University, 80336 Munich, Germany.

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http://dx.doi.org/10.1111/j.1471-4159.2004.02447.xDOI Listing
June 2004

Requirement of PEN-2 for stabilization of the presenilin N-/C-terminal fragment heterodimer within the gamma-secretase complex.

Authors:
Stefan Prokop Keiro Shirotani Dieter Edbauer Christian Haass Harald Steiner

J Biol Chem 2004 May 23;279(22):23255-61. Epub 2004 Mar 23.

Adolf-Butenandt-Institute, Department of Biochemistry, Laboratory for Alzheimer's and Parkinson's Disease Research, Schillerstrasse 44, Ludwig-Maximilians-University, 80336 Munich, Germany.

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http://dx.doi.org/10.1074/jbc.M401789200DOI Listing
May 2004

Nicastrin interacts with gamma-secretase complex components via the N-terminal part of its transmembrane domain.

Authors:
Anja Capell Christoph Kaether Dieter Edbauer Keiro Shirotani Sabine Merkl Harald Steiner Christian Haass

J Biol Chem 2003 Dec 5;278(52):52519-23. Epub 2003 Nov 5.

Adolf-Butenandt-Institute, Department of Biochemistry, Laboratory for Alzheimer's and Parkinson's Disease Research, Schillerstrasse 44, Ludwig-Maximilians-University, 80336 Munich, Germany.

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http://www.jbc.org/lookup/doi/10.1074/jbc.C300435200
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December 2003

Gamma-secretase activity is associated with a conformational change of nicastrin.

Authors:
Keiro Shirotani Dieter Edbauer Anja Capell Julia Schmitz Harald Steiner Christian Haass

J Biol Chem 2003 May 18;278(19):16474-7. Epub 2003 Mar 18.

Adolf Butenandt-Institute, Department of Biochemistry, Laboratory for Alzheimer's and Parkinson's Disease Research, Ludwig-Maximilians-University, Schillerstrasse 44, 80336 Munich, Germany.

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http://dx.doi.org/10.1074/jbc.C300095200DOI Listing
May 2003

Reconstitution of gamma-secretase activity.

Authors:
Dieter Edbauer Edith Winkler Joerg T Regula Brigitte Pesold Harald Steiner Christian Haass

Nat Cell Biol 2003 May;5(5):486-8

Adolf-Butenandt-Institute, Department of Biochemistry, Laboratory for Alzheimer's and Parkinson's Disease Research, Ludwig-Maximilians-University, 80336 Munich, Germany.

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http://dx.doi.org/10.1038/ncb960DOI Listing
May 2003

Alzheimer disease gamma-secretase: a complex story of GxGD-type presenilin proteases.

Authors:
Christian Haass Harald Steiner

Trends Cell Biol 2002 Dec;12(12):556-62

Adolf-Butenandt-Institute, Dept of Biochemistry, Laboratory for Alzheimer's and Parkinson's Disease Research, Ludwig-Maximilians-University Munich, Schillerstr. 44, 80336 Munich, Germany.

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December 2002

Presenilin-dependent intramembrane proteolysis of CD44 leads to the liberation of its intracellular domain and the secretion of an Abeta-like peptide.

Authors:
Sven Lammich Masayasu Okochi Masatoshi Takeda Christoph Kaether Anja Capell Ann-Katrin Zimmer Dieter Edbauer Jochen Walter Harald Steiner Christian Haass

J Biol Chem 2002 Nov 9;277(47):44754-9. Epub 2002 Sep 9.

Adolf-Butenandt-Institute, Department of Biochemistry, Laboratory for Alzheimer's and Parkinson's Disease Research, Ludwig-Maximilians-University, 80336 Munich, Germany.

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http://dx.doi.org/10.1074/jbc.M206872200DOI Listing
November 2002

PEN-2 is an integral component of the gamma-secretase complex required for coordinated expression of presenilin and nicastrin.

Authors:
Harald Steiner Edith Winkler Dieter Edbauer Stefan Prokop Gabriele Basset Aya Yamasaki Marcus Kostka Christian Haass

J Biol Chem 2002 Oct 26;277(42):39062-5. Epub 2002 Aug 26.

Adolf-Butenandt-Institute, Department of Biochemistry, Laboratory for Alzheimer's and Parkinson's Disease Research, Schillerstrasse 44, Ludwig-Maximilians-University, 80336 Munich, Germany.

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http://dx.doi.org/10.1074/jbc.C200469200DOI Listing
October 2002

Presenilins mediate a dual intramembranous gamma-secretase cleavage of Notch-1.

Authors:
Masayasu Okochi Harald Steiner Akio Fukumori Hisashi Tanii Taisuke Tomita Toshihisa Tanaka Takeshi Iwatsubo Takashi Kudo Masatoshi Takeda Christian Haass

EMBO J 2002 Oct;21(20):5408-16

Department of Post-Genomics and Diseases, Division of Psychiatry and Behavioral Proteomics, Osaka University Graduate School of Medicine, 565-0871 Osaka, Japan.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC129073PMC
http://dx.doi.org/10.1093/emboj/cdf541DOI Listing
October 2002

Presenilin-1 affects trafficking and processing of betaAPP and is targeted in a complex with nicastrin to the plasma membrane.

Authors:
Christoph Kaether Sven Lammich Dieter Edbauer Michaela Ertl Jens Rietdorf Anja Capell Harald Steiner Christian Haass

J Cell Biol 2002 Aug 29;158(3):551-61. Epub 2002 Jul 29.

Adolf-Butenandt-Institute, Department of Biochemistry, Laboratory for Alzheimer's and Parkinson's Disease Research, Ludwig-Maximilians-University, 80336 Munich, Germany.

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http://dx.doi.org/10.1083/jcb.200201123DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2173840PMC
August 2002

A gamma-secretase inhibitor blocks Notch signaling in vivo and causes a severe neurogenic phenotype in zebrafish.

Authors:
Andrea Geling Harald Steiner Michael Willem Laure Bally-Cuif Christian Haass

EMBO Rep 2002 Jul;3(7):688-94

Zebrafish Neurogenetics Junior Research Group, Institute for Virology, Technical University Munich, Trogerstrasse, Germany.

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http://dx.doi.org/10.1093/embo-reports/kvf124DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1084181PMC
July 2002

Presenilin-1 mutations of leucine 166 equally affect the generation of the Notch and APP intracellular domains independent of their effect on Abeta 42 production.

Authors:
Tobias Moehlmann Edith Winkler Xuefeng Xia Dieter Edbauer Jill Murrell Anja Capell Christoph Kaether Hui Zheng Bernardino Ghetti Christian Haass Harald Steiner

Proc Natl Acad Sci U S A 2002 Jun 4;99(12):8025-30. Epub 2002 Jun 4.

Adolf Butenandt-Institute, Department of Biochemistry, Laboratory for Alzheimer's Disease Research, Ludwig-Maximilians-University, 80336 Munich, Germany.

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http://www.pnas.org/cgi/doi/10.1073/pnas.112686799
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http://dx.doi.org/10.1073/pnas.112686799DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC123014PMC
June 2002

Presenilin and nicastrin regulate each other and determine amyloid beta-peptide production via complex formation.

Authors:
Dieter Edbauer Edith Winkler Christian Haass Harald Steiner

Proc Natl Acad Sci U S A 2002 Jun 4;99(13):8666-71. Epub 2002 Jun 4.

Adolf-Butenandt-Institute, Department of Biochemistry, Laboratory for Alzheimer's and Parkinson's Disease Research, Schillerstrasse 44, Ludwig-Maximilians-University, 80336 Munich, Germany.

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http://dx.doi.org/10.1073/pnas.132277899DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC124353PMC
June 2002

Insulin-degrading enzyme rapidly removes the beta-amyloid precursor protein intracellular domain (AICD).

Authors:
Dieter Edbauer Michael Willem Sven Lammich Harald Steiner Christian Haass

J Biol Chem 2002 Apr 23;277(16):13389-93. Epub 2002 Jan 23.

Department of Biochemistry, Laboratory for Alzheimer's and Parkinson's Disease Research, Adolf-Butenandt-Institute, Ludwig-Maximilians-University, Schillerstrasse 44, 80336 Munich, Germany.

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http://dx.doi.org/10.1074/jbc.M111571200DOI Listing
April 2002