Harald Steiner

Harald Steiner

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Harald Steiner

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Identification of a rare presenilin 1 single amino acid deletion mutation (F175del) with unusual amyloid-β processing effects.

Neurobiol Aging 2019 Sep 20. Epub 2019 Sep 20.

Department of Neurology, Ludwig-Maximilians-Universität München, Munich, Germany; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2019.08.034DOI Listing
September 2019

Modulating Hinge Flexibility in the APP Transmembrane Domain Alters γ-Secretase Cleavage.

Biophys J 2019 Jun 3;116(11):2103-2120. Epub 2019 May 3.

Biomedical Center (BMC), Metabolic Biochemistry, Ludwig-Maximilians-University, Munich, Germany; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00063495193037
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http://dx.doi.org/10.1016/j.bpj.2019.04.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6554489PMC
June 2019

Comparison of Strategies for the Determination of Sterol Sulfates via GC-MS Leading to a Novel Deconjugation-Derivatization Protocol.

Molecules 2019 Jun 26;24(13). Epub 2019 Jun 26.

Department of Pharmacy-Center for Drug Research, Ludwig-Maximilians University Munich, Butenandtstraße 5-13, 81377 Munich, Germany.

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http://dx.doi.org/10.3390/molecules24132353DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6651411PMC
June 2019

Dual Resonator MEMS Magnetic Field Gradiometer.

Sensors (Basel) 2019 Jan 25;19(3). Epub 2019 Jan 25.

Institute of Sensor and Actuator Systems, TU Wien, 1040 Vienna, Austria.

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http://dx.doi.org/10.3390/s19030493DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6387345PMC
January 2019

Making the final cut: pathogenic amyloid-β peptide generation by γ-secretase.

Cell Stress 2018 Oct 28;2(11):292-310. Epub 2018 Oct 28.

Neuropsychiatry, Department of Integrated Medicine, Division of Internal Medicine, Osaka University Graduate School of Medicine, Suita, Japan.

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http://dx.doi.org/10.15698/cst2018.11.162DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6551803PMC
October 2018

Substrate recruitment of γ-secretase and mechanism of clinical presenilin mutations revealed by photoaffinity mapping.

EMBO J 2016 08 23;35(15):1628-43. Epub 2016 May 23.

Biomedical Center (BMC), Metabolic Biochemistry, Ludwig-Maximilians-University Munich, Munich, Germany German Center for Neurodegenerative Diseases (DZNE), Munich, Germany

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http://dx.doi.org/10.15252/embj.201694151DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4883025PMC
August 2016

Generation and deposition of Aβ43 by the virtually inactive presenilin-1 L435F mutant contradicts the presenilin loss-of-function hypothesis of Alzheimer's disease.

EMBO Mol Med 2016 05 2;8(5):458-65. Epub 2016 May 2.

Biomedical Center, Metabolic Biochemistry, Ludwig-Maximilians-University Munich, Munich, Germany DZNE - German Center for Neurodegenerative Diseases, Munich, Germany

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http://dx.doi.org/10.15252/emmm.201505952DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5119496PMC
May 2016

Proteolytic Processing of Neuregulin 1 Type III by Three Intramembrane-cleaving Proteases.

J Biol Chem 2016 Jan 16;291(1):318-33. Epub 2015 Nov 16.

From the Biomedical Center, Biochemistry, Ludwig-Maximilians-University Munich, 81377 Munich, the German Center for Neurodegenerative Diseases (DZNE), Munich, 81377 Munich, the Munich Cluster for Systems Neurology (SyNergy), 81377 Munich, and

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http://www.jbc.org/content/291/1/318.full.pdf
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http://www.jbc.org/lookup/doi/10.1074/jbc.M115.697995
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http://dx.doi.org/10.1074/jbc.M115.697995DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4697167PMC
January 2016

Homodimerization Protects the Amyloid Precursor Protein C99 Fragment from Cleavage by γ-Secretase.

Biochemistry 2015 Oct 29;54(40):6149-52. Epub 2015 Sep 29.

Lehrstuhl Chemie der Biopolymere, Technische Universität München , Weihenstephaner Berg 3, 85354 Freising, Germany.

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http://dx.doi.org/10.1021/acs.biochem.5b00986DOI Listing
October 2015

Inhibition of amyloid-β plaque formation by α-synuclein.

Nat Med 2015 Jul 22;21(7):802-7. Epub 2015 Jun 22.

1] Adolf Butenandt Institute, Department of Biochemistry, Ludwig-Maximilians University, Munich, Germany. [2] Neurocenter, Department of Neurology, University of Freiburg, Freiburg, Germany.

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http://dx.doi.org/10.1038/nm.3885DOI Listing
July 2015

Intramembrane proteolysis of β-amyloid precursor protein by γ-secretase is an unusually slow process.

Biophys J 2015 Mar;108(5):1229-37

Metabolic Biochemistry, Ludwig-Maximilians-University, München, Germany; DZNE-German Center for Neurodegenerative Diseases, Munich, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.bpj.2014.12.045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4375682PMC
March 2015

Shedding of glycan-modifying enzymes by signal peptide peptidase-like 3 (SPPL3) regulates cellular N-glycosylation.

EMBO J 2014 Dec 29;33(24):2890-905. Epub 2014 Oct 29.

Adolf Butenandt Institute for Biochemistry, Ludwig-Maximilians University Munich, Munich, Germany DZNE - German Center for Neurodegenerative Diseases, Munich, Germany

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http://dx.doi.org/10.15252/embj.201488375DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4282638PMC
December 2014

The yeast ER-intramembrane protease Ypf1 refines nutrient sensing by regulating transporter abundance.

Mol Cell 2014 Dec 13;56(5):630-40. Epub 2014 Nov 13.

Zentrum für Molekulare Biologie der Universität Heidelberg (ZMBH), DKFZ-ZMBH Allianz, Im Neuenheimer Feld 282, 69120 Heidelberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2014.10.012DOI Listing
December 2014

Generation of Alzheimer disease-associated amyloid β42/43 peptide by γ-secretase can be inhibited directly by modulation of membrane thickness.

J Biol Chem 2012 Jun 24;287(25):21326-34. Epub 2012 Apr 24.

Adolf Butenandt Institute, Biochemistry, Ludwig Maximilians University Munich, Schillerstrasse 44, 80336 Munich, Germany.

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http://dx.doi.org/10.1074/jbc.M112.356659DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3375553PMC
June 2012

The Nicastrin ectodomain adopts a highly thermostable structure.

Biol Chem 2011 Nov;392(11):995-1001

Adolf-Butenandt-Institute, Biochemistry, Ludwig Maximilians University, Schillerstrasse 44, 80336 Munich, Germany.

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http://dx.doi.org/10.1515/BC.2011.169DOI Listing
November 2011

Novel γ-secretase enzyme modulators directly target presenilin protein.

J Biol Chem 2011 Oct 6;286(43):37181-6. Epub 2011 Sep 6.

Adolf-Butenandt-Institute, Biochemistry, Ludwig-Maximilians-University, 80336 Munich, Germany.

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http://dx.doi.org/10.1074/jbc.C111.276972DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3199465PMC
October 2011

Regulated intramembrane proteolysis--lessons from amyloid precursor protein processing.

J Neurochem 2011 Jun 14;117(5):779-96. Epub 2011 Apr 14.

DZNE-German Center for Neurodegenerative Diseases, Adolf-Butenandt-Institute, Biochemistry, Ludwig-Maximilians-University, Munich, Germany.

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http://dx.doi.org/10.1111/j.1471-4159.2011.07248.xDOI Listing
June 2011

Beta-amyloid precursor protein mutants respond to gamma-secretase modulators.

J Biol Chem 2010 Jun 26;285(23):17798-810. Epub 2010 Mar 26.

German Center for Neurodegenerative Diseases DZNE)and Adolf-Butenandt-Institute, Biochemistry, Ludwig-Maximilians-University, 80336 Munich, Germany.

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http://dx.doi.org/10.1074/jbc.M110.103283DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2878544PMC
June 2010

Inhibition of gamma-secretase by the CK1 inhibitor IC261 does not depend on CK1delta.

Bioorg Med Chem Lett 2010 May 4;20(9):2958-63. Epub 2010 Mar 4.

Clemens Schöpf-Institute of Chemistry and Biochemistry, Technische Universität Darmstadt, Petersenstr. 22, D-64287 Darmstadt, Germany.

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http://dx.doi.org/10.1016/j.bmcl.2010.02.110DOI Listing
May 2010

Requirement for small side chain residues within the GxGD-motif of presenilin for gamma-secretase substrate cleavage.

J Neurochem 2010 Feb 15;112(4):940-50. Epub 2009 Dec 15.

Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE) and Adolf-Butenandt-Institute, Biochemistry, Ludwig-Maximilians-University, München, Germany.

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http://dx.doi.org/10.1111/j.1471-4159.2009.06510.xDOI Listing
February 2010

Intramembrane proteolysis by signal peptide peptidases: a comparative discussion of GXGD-type aspartyl proteases.

J Biol Chem 2009 May 3;284(21):13975-9. Epub 2009 Feb 3.

Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE) and Adolf Butenandt Institute, Biochemistry, Ludwig-Maximilians University, Munich, 80336 Munich, Germany.

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http://dx.doi.org/10.1074/jbc.R800040200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2682845PMC
May 2009

Purification, pharmacological modulation, and biochemical characterization of interactors of endogenous human gamma-secretase.

Biochemistry 2009 Feb;48(6):1183-97

Center for Integrated Protein Science Munich and Adolf-Butenandt-Institute, Department of Biochemistry, Laboratory for Neurodegenerative Disease Research, Ludwig-Maximilians-University, 80336 Munich, Germany.

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http://pubs.acs.org/doi/abs/10.1021/bi801204g
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http://dx.doi.org/10.1021/bi801204gDOI Listing
February 2009

Chemical cross-linking provides a model of the gamma-secretase complex subunit architecture and evidence for close proximity of the C-terminal fragment of presenilin with APH-1.

J Biol Chem 2008 Dec 18;283(50):34677-86. Epub 2008 Sep 18.

Center for Integrated Protein Science Munich and Adolf-Butenandt-Institute, Department of Biochemistry, Laboratory for Neurodegenerative Disease Research, Ludwig-Maximilians-University, 80336 Munich, Germany.

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http://dx.doi.org/10.1074/jbc.M709067200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3259863PMC
December 2008

Intramembrane proteolysis by gamma-secretase.

J Biol Chem 2008 Oct 23;283(44):29627-31. Epub 2008 Jul 23.

Center for Integrated Protein Science Munich and Adolf Butenandt Institute, Department of Biochemistry, Laboratory for Neurodegenerative Disease Research, Ludwig Maximilians University, 80336 Munich, Germany.

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http://dx.doi.org/10.1074/jbc.R800010200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2662049PMC
October 2008

Intramembrane proteolysis of GXGD-type aspartyl proteases is slowed by a familial Alzheimer disease-like mutation.

J Biol Chem 2008 Oct 3;283(44):30121-8. Epub 2008 Sep 3.

Center for Integrated Protein Science Munich and Adolf-Butenandt-Institute, Department of Biochemistry, Laboratory for Neurodegenerative Disease Research, Ludwig-Maximilians-University, Munich 80336, Germany.

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http://dx.doi.org/10.1074/jbc.M806092200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2573083PMC
October 2008

The catalytic core of gamma-secretase: presenilin revisited.

Authors:
Harald Steiner

Curr Alzheimer Res 2008 Apr;5(2):147-57

Adolf-Butenandt-Institute, Department of Biochemistry, Laboratory for Neurodegenerative Disease Research, Schil-lerstr. 44, Ludwig-Maximilians-University, 80336 Munich, Germany.

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April 2008

Generation of Abeta38 and Abeta42 is independently and differentially affected by familial Alzheimer disease-associated presenilin mutations and gamma-secretase modulation.

J Biol Chem 2008 Jan 24;283(2):677-83. Epub 2007 Oct 24.

Center for Integrated Protein Science Munich and Adolf Butenandt Institute, Department of Biochemistry, Laboratory for Neurodegenerative Disease Research, Ludwig Maximilians University, 80336 Munich, Germany.

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http://dx.doi.org/10.1074/jbc.M708754200DOI Listing
January 2008

Active gamma-secretase complexes contain only one of each component.

J Biol Chem 2007 Nov 2;282(47):33985-93. Epub 2007 Oct 2.

Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1074/jbc.M705248200DOI Listing
November 2007

Endoplasmic reticulum retention of the gamma-secretase complex component Pen2 by Rer1.

EMBO Rep 2007 Aug 6;8(8):743-8. Epub 2007 Jul 6.

Laboratory for Alzheimer's and Parkinson's Disease Research, Department of Biochemistry, Center For Integrated Protein Science Munich and Adolf-Butenandt-Institute, Ludwig-Maximilians-Universität, München 80336, Germany.

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http://dx.doi.org/10.1038/sj.embor.7401027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1978084PMC
August 2007

Pathological activity of familial Alzheimer's disease-associated mutant presenilin can be executed by six different gamma-secretase complexes.

Neurobiol Dis 2007 Jul 6;27(1):102-7. Epub 2007 May 6.

Munich Center for Integrated Protein Science and Adolf-Butenandt-Institute, Department of Biochemistry, Laboratory for Alzheimer's and Parkinson's Disease Research, Ludwig-Maximilians-University, Schillerstr 44, Munich, Germany.

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http://dx.doi.org/10.1016/j.nbd.2007.04.011DOI Listing
July 2007

Sheddases and intramembrane-cleaving proteases: RIPpers of the membrane. Symposium on regulated intramembrane proteolysis.

EMBO Rep 2007 Jun 11;8(6):537-41. Epub 2007 May 11.

Adolf-Butenandt-Institute, Department of Biochemistry, Laboratory of Alzheimer's and Parkinson's Disease Research, Ludwig-Maximilians-University, Schillerstrasse 44, 80336 Munich, Germany.

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http://dx.doi.org/10.1038/sj.embor.7400978DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2002526PMC
June 2007

N-Substituted carbazolyloxyacetic acids modulate Alzheimer associated gamma-secretase.

Bioorg Med Chem Lett 2007 Jan 10;17(1):176-82. Epub 2006 Oct 10.

Clemens Schöpf-Institute of Chemistry and Biochemistry, Darmstadt University of Technology, Petersenstr. 22, D-64287 Darmstadt, Germany.

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http://dx.doi.org/10.1016/j.bmcl.2006.09.061DOI Listing
January 2007

Assembly, trafficking and function of gamma-secretase.

Neurodegener Dis 2006 ;3(4-5):275-83

Laboratory for Alzheimer's and Parkinson's Disease Research, Department of Biochemistry, Adolf Butenandt Institute, Ludwig Maximilians University, Munich, Germany.

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https://www.karger.com/Article/FullText/95267
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http://dx.doi.org/10.1159/000095267DOI Listing
December 2006

Scaffold of the cyclooxygenase-2 (COX-2) inhibitor carprofen provides Alzheimer gamma-secretase modulators.

J Med Chem 2006 Dec;49(26):7588-91

Clemens Schöpf-Institute of Chemistry and Biochemistry, Darmstadt University of Technology, Petersenstrasse 22, D-64287 Darmstadt, Germany.

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http://dx.doi.org/10.1021/jm0610200DOI Listing
December 2006

Pore-forming scissors? A first structural glimpse of gamma-secretase.

Trends Biochem Sci 2006 Sep 4;31(9):491-3. Epub 2006 Aug 4.

Adolf-Butenandt-Institute, Department of Biochemistry, Laboratory for Alzheimer's and Parkinson's Disease Research, Ludwig-Maximilians University, Schillerstrasse 44, 80336 Munich, Germany.

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http://dx.doi.org/10.1016/j.tibs.2006.07.008DOI Listing
September 2006

SorLA signaling by regulated intramembrane proteolysis.

J Biol Chem 2006 May 10;281(21):14547-53. Epub 2006 Mar 10.

University Medical Center Hamburg-Eppendorf, Center of Experimental Medicine, Department of Biochemistry and Molecular Biology II: Molecular Cell Biology, Martinistrasse 52, D-20246 Hamburg, Germany.

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http://dx.doi.org/10.1074/jbc.M601660200DOI Listing
May 2006

The GxGD motif of presenilin contributes to catalytic function and substrate identification of gamma-secretase.

J Neurosci 2006 Apr;26(14):3821-8

Laboratory for Alzheimer's and Parkinson's Disease Research, Department of Biochemistry, Adolf Butenandt Institute, Ludwig Maximilians University, 80336 Munich, Germany.

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http://dx.doi.org/10.1523/JNEUROSCI.5354-05.2006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6674133PMC
April 2006

Secretion of the Notch-1 Abeta-like peptide during Notch signaling.

J Biol Chem 2006 Mar 23;281(12):7890-8. Epub 2006 Jan 23.

Department of Post-Genomics and Diseases, Division of Psychiatry and Behavioral Proteomics, Osaka University Graduate School of Medicine, Osaka 565-0871, Japan.

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http://dx.doi.org/10.1074/jbc.M513250200DOI Listing
March 2006

Differential localization and identification of a critical aspartate suggest non-redundant proteolytic functions of the presenilin homologues SPPL2b and SPPL3.

J Biol Chem 2005 Nov 5;280(47):39515-23. Epub 2005 Jul 5.

Adolf-Butenandt-Institute, Department of Biochemistry, Laboratory for Alzheimer's and Parkinson's Disease Research, Ludwig-Maximilians-University, Schillerstrasse 44, 80336 Munich, Germany.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M501645200
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http://dx.doi.org/10.1074/jbc.M501645200DOI Listing
November 2005

Length and overall sequence of the PEN-2 C-terminal domain determines its function in the stabilization of presenilin fragments.

J Neurochem 2005 Jul;94(1):57-62

Adolf-Butenandt-Institute, Department of Biochemistry, Laboratory for Alzheimer's and Parkinson's Disease Research, Ludwig-Maximilians-University, Munich, Germany.

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http://doi.wiley.com/10.1111/j.1471-4159.2005.03165.x
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http://dx.doi.org/10.1111/j.1471-4159.2005.03165.xDOI Listing
July 2005

Gamma-secretase complex assembly within the early secretory pathway.

J Biol Chem 2005 Feb 10;280(8):6471-8. Epub 2004 Dec 10.

Adolf-Butenandt-Institut, Department of Biochemistry, Laboratory for Alzheimer's and Parkinson's Disease Research, Ludwig-Maximilians-Universität, Schillerstrasse 44, 80336 Munich, Germany.

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http://dx.doi.org/10.1074/jbc.M409106200DOI Listing
February 2005

The presenilin C-terminus is required for ER-retention, nicastrin-binding and gamma-secretase activity.

EMBO J 2004 Dec 18;23(24):4738-48. Epub 2004 Nov 18.

Laboratory for Alzheimer's and Parkinson's Disease Research, Department of Biochemistry, Adolf-Butenandt-Institute, Ludwig-Maximilians-Universität, München, Germany.

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http://dx.doi.org/10.1038/sj.emboj.7600478DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC535090PMC
December 2004

Identification of distinct gamma-secretase complexes with different APH-1 variants.

J Biol Chem 2004 Oct 30;279(40):41340-5. Epub 2004 Jul 30.

Adolf-Butenandt-Institute, Department of Biochemistry, Laboratory for Alzheimer's and Parkinson's Disease Research, Schillerstrasse 44, Ludwig-Maximilians-University, 80336 Munich, Germany.

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http://dx.doi.org/10.1074/jbc.M405768200DOI Listing
October 2004

Co-expression of nicastrin and presenilin rescues a loss of function mutant of APH-1.

J Biol Chem 2004 Sep 21;279(36):37311-5. Epub 2004 Jun 21.

Adolf-Butenandt-Institute, Department of Biochemistry, Laboratory for Alzheimer's and Parkinson's Disease Research, Schillerstr. 44, Ludwig-Maximilians-University, 80336 Munich, Germany.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M406228200
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http://dx.doi.org/10.1074/jbc.M406228200DOI Listing
September 2004

Uncovering gamma-secretase.

Authors:
Harald Steiner

Curr Alzheimer Res 2004 Aug;1(3):175-81

Adolf-Butenandt-Institute, Department of Biochemistry, Laboratory for Alzheimer's and Parkinson's Disease Research, Schillerstrasse 44, Ludwig-Maximilians-University, 80336 Munich, Germany.

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August 2004

Immature nicastrin stabilizes APH-1 independent of PEN-2 and presenilin: identification of nicastrin mutants that selectively interact with APH-1.

J Neurochem 2004 Jun;89(6):1520-7

Adolf-Butenandt Institute, Department of Biochemistry, Laboratory for Alzheimer's and Parkinson's Disease Research, Ludwig-Maximilians University, 80336 Munich, Germany.

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http://dx.doi.org/10.1111/j.1471-4159.2004.02447.xDOI Listing
June 2004

Requirement of PEN-2 for stabilization of the presenilin N-/C-terminal fragment heterodimer within the gamma-secretase complex.

J Biol Chem 2004 May 23;279(22):23255-61. Epub 2004 Mar 23.

Adolf-Butenandt-Institute, Department of Biochemistry, Laboratory for Alzheimer's and Parkinson's Disease Research, Schillerstrasse 44, Ludwig-Maximilians-University, 80336 Munich, Germany.

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http://dx.doi.org/10.1074/jbc.M401789200DOI Listing
May 2004

Nicastrin interacts with gamma-secretase complex components via the N-terminal part of its transmembrane domain.

J Biol Chem 2003 Dec 5;278(52):52519-23. Epub 2003 Nov 5.

Adolf-Butenandt-Institute, Department of Biochemistry, Laboratory for Alzheimer's and Parkinson's Disease Research, Schillerstrasse 44, Ludwig-Maximilians-University, 80336 Munich, Germany.

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http://www.jbc.org/lookup/doi/10.1074/jbc.C300435200
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http://dx.doi.org/10.1074/jbc.C300435200DOI Listing
December 2003

Gamma-secretase activity is associated with a conformational change of nicastrin.

J Biol Chem 2003 May 18;278(19):16474-7. Epub 2003 Mar 18.

Adolf Butenandt-Institute, Department of Biochemistry, Laboratory for Alzheimer's and Parkinson's Disease Research, Ludwig-Maximilians-University, Schillerstrasse 44, 80336 Munich, Germany.

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http://dx.doi.org/10.1074/jbc.C300095200DOI Listing
May 2003

Reconstitution of gamma-secretase activity.

Nat Cell Biol 2003 May;5(5):486-8

Adolf-Butenandt-Institute, Department of Biochemistry, Laboratory for Alzheimer's and Parkinson's Disease Research, Ludwig-Maximilians-University, 80336 Munich, Germany.

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http://dx.doi.org/10.1038/ncb960DOI Listing
May 2003

Alzheimer disease gamma-secretase: a complex story of GxGD-type presenilin proteases.

Trends Cell Biol 2002 Dec;12(12):556-62

Adolf-Butenandt-Institute, Dept of Biochemistry, Laboratory for Alzheimer's and Parkinson's Disease Research, Ludwig-Maximilians-University Munich, Schillerstr. 44, 80336 Munich, Germany.

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December 2002

Presenilin-dependent intramembrane proteolysis of CD44 leads to the liberation of its intracellular domain and the secretion of an Abeta-like peptide.

J Biol Chem 2002 Nov 9;277(47):44754-9. Epub 2002 Sep 9.

Adolf-Butenandt-Institute, Department of Biochemistry, Laboratory for Alzheimer's and Parkinson's Disease Research, Ludwig-Maximilians-University, 80336 Munich, Germany.

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http://dx.doi.org/10.1074/jbc.M206872200DOI Listing
November 2002

PEN-2 is an integral component of the gamma-secretase complex required for coordinated expression of presenilin and nicastrin.

J Biol Chem 2002 Oct 26;277(42):39062-5. Epub 2002 Aug 26.

Adolf-Butenandt-Institute, Department of Biochemistry, Laboratory for Alzheimer's and Parkinson's Disease Research, Schillerstrasse 44, Ludwig-Maximilians-University, 80336 Munich, Germany.

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http://dx.doi.org/10.1074/jbc.C200469200DOI Listing
October 2002

Presenilins mediate a dual intramembranous gamma-secretase cleavage of Notch-1.

EMBO J 2002 Oct;21(20):5408-16

Department of Post-Genomics and Diseases, Division of Psychiatry and Behavioral Proteomics, Osaka University Graduate School of Medicine, 565-0871 Osaka, Japan.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC129073PMC
http://dx.doi.org/10.1093/emboj/cdf541DOI Listing
October 2002

Presenilin-1 affects trafficking and processing of betaAPP and is targeted in a complex with nicastrin to the plasma membrane.

J Cell Biol 2002 Aug 29;158(3):551-61. Epub 2002 Jul 29.

Adolf-Butenandt-Institute, Department of Biochemistry, Laboratory for Alzheimer's and Parkinson's Disease Research, Ludwig-Maximilians-University, 80336 Munich, Germany.

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http://dx.doi.org/10.1083/jcb.200201123DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2173840PMC
August 2002

A gamma-secretase inhibitor blocks Notch signaling in vivo and causes a severe neurogenic phenotype in zebrafish.

EMBO Rep 2002 Jul;3(7):688-94

Zebrafish Neurogenetics Junior Research Group, Institute for Virology, Technical University Munich, Trogerstrasse, Germany.

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http://dx.doi.org/10.1093/embo-reports/kvf124DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1084181PMC
July 2002

Presenilin-1 mutations of leucine 166 equally affect the generation of the Notch and APP intracellular domains independent of their effect on Abeta 42 production.

Proc Natl Acad Sci U S A 2002 Jun 4;99(12):8025-30. Epub 2002 Jun 4.

Adolf Butenandt-Institute, Department of Biochemistry, Laboratory for Alzheimer's Disease Research, Ludwig-Maximilians-University, 80336 Munich, Germany.

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http://www.pnas.org/cgi/doi/10.1073/pnas.112686799
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http://dx.doi.org/10.1073/pnas.112686799DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC123014PMC
June 2002

Presenilin and nicastrin regulate each other and determine amyloid beta-peptide production via complex formation.

Proc Natl Acad Sci U S A 2002 Jun 4;99(13):8666-71. Epub 2002 Jun 4.

Adolf-Butenandt-Institute, Department of Biochemistry, Laboratory for Alzheimer's and Parkinson's Disease Research, Schillerstrasse 44, Ludwig-Maximilians-University, 80336 Munich, Germany.

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http://dx.doi.org/10.1073/pnas.132277899DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC124353PMC
June 2002

Insulin-degrading enzyme rapidly removes the beta-amyloid precursor protein intracellular domain (AICD).

J Biol Chem 2002 Apr 23;277(16):13389-93. Epub 2002 Jan 23.

Department of Biochemistry, Laboratory for Alzheimer's and Parkinson's Disease Research, Adolf-Butenandt-Institute, Ludwig-Maximilians-University, Schillerstrasse 44, 80336 Munich, Germany.

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http://dx.doi.org/10.1074/jbc.M111571200DOI Listing
April 2002