Harald Staiger

Harald Staiger

UNVERIFIED PROFILE

Are you Harald Staiger?   Register this Author

Register author
Harald Staiger

Harald Staiger

Publications by authors named "Harald Staiger"

Are you Harald Staiger?   Register this Author

100Publications

3341Reads

50Profile Views

AMPK subunits harbor largely non-overlapping genetic determinants for body fat mass, glucose- and cholesterol metabolism.

J Clin Endocrinol Metab 2019 Sep 12. Epub 2019 Sep 12.

Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Centre Munich at the University of Tübingen, Tübingen, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1210/clinem/dgz020DOI Listing
September 2019

Generation of a human induced pluripotent stem cell line (HMGUi002-A) from a healthy male individual.

Stem Cell Res 2019 08 7;39:101531. Epub 2019 Aug 7.

Institute of Diabetes and Regeneration Research, Helmholtz Zentrum München, 85764 Neuherberg, Germany; Institute of Stem Cell Research, Helmholtz Zentrum München, 85764 Neuherberg, Germany; Technische Universität München, Ismaningerstraße 22, 81675 München, Germany; German Center for Diabetes Research (DZD), 85764 Neuherberg, Germany. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.scr.2019.101531DOI Listing
August 2019

What role do fat cells play in pancreatic tissue?

Mol Metab 2019 07 7;25:1-10. Epub 2019 May 7.

German Center for Diabetes Research (DZD), Tübingen, Germany; Institute for Diabetes Research and Metabolic Diseases, Helmholtz Center Munich, Eberhard Karls University of Tübingen, Tübingen, Germany. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.molmet.2019.05.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6600604PMC
July 2019

Point mutations in the PDX1 transactivation domain impair human β-cell development and function.

Mol Metab 2019 06 20;24:80-97. Epub 2019 Mar 20.

Institute of Diabetes and Regeneration Research, Helmholtz Zentrum München, 85764 Neuherberg, Germany; Institute of Stem Cell Research, Helmholtz Zentrum München, 85764 Neuherberg, Germany; Technische Universität München, Ismaningerstraße 22, 81675 München, Germany; German Center for Diabetes Research (DZD), 85764 Neuherberg, Germany. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.molmet.2019.03.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6531841PMC
June 2019

Circulating FGF21 Levels in Human Health and Metabolic Disease.

Exp Clin Endocrinol Diabetes 2019 May 20. Epub 2019 May 20.

Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the Eberhard Karls University Tübingen, Tübingen, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/a-0879-2968DOI Listing
May 2019

Preadipocytes of obese humans display gender-specific bioenergetic responses to glucose and insulin.

Mol Metab 2019 02 26;20:28-37. Epub 2018 Nov 26.

Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the University of Tübingen, Tübingen, Germany; German Center for Diabetes Research (DZD), Neuherberg, Germany; Institute of Pharmaceutical Sciences, Department of Pharmacy and Biochemistry, Eberhard Karls University Tübingen, Tübingen, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.molmet.2018.11.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358537PMC
February 2019

Gene x Gene Interactions Highlight the Role of Incretin Resistance for Insulin Secretion.

Front Endocrinol (Lausanne) 2019 21;10:72. Epub 2019 Feb 21.

Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the University of Tübingen, Tübingen, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fendo.2019.00072DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6393347PMC
February 2019

BMI-Independent Effects of Gestational Diabetes on Human Placenta.

J Clin Endocrinol Metab 2018 09;103(9):3299-3309

Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Zentrum München at Eberhard Karls University Tübingen, Tübingen, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1210/jc.2018-00397DOI Listing
September 2018

Pharmacogenetics: Implications for Modern Type 2 Diabetes Therapy.

Rev Diabet Stud 2015 Fall-Winter;12(3-4):363-76. Epub 2016 Feb 10.

Interfaculty Centre for Pharmacogenomics and Pharma Research at the University of Tübingen, Tübingen, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1900/RDS.2015.12.363DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5275760PMC
July 2018

Effects of resveratrol supplementation on liver fat content in overweight and insulin-resistant subjects: A randomized, double-blind, placebo-controlled clinical trial.

Diabetes Obes Metab 2018 07 22;20(7):1793-1797. Epub 2018 Mar 22.

Department of Internal Medicine IV, Division of Endocrinology, Diabetology, Vascular Medicine, Nephrology and Clinical Chemistry, University of Tübingen, Tübingen, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/dom.13268DOI Listing
July 2018

A computational biology approach of a genome-wide screen connected miRNAs to obesity and type 2 diabetes.

Mol Metab 2018 05 15;11:145-159. Epub 2018 Mar 15.

German Institute of Human Nutrition Potsdam-Rehbruecke, Department of Experimental Diabetology, 14558, Nuthetal, Germany; German Center for Diabetes Research (DZD), 85764, München-Neuherberg, Germany. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S22128778183013
Publisher Site
http://dx.doi.org/10.1016/j.molmet.2018.03.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6001404PMC
May 2018

Pharmacogenetics of oral antidiabetic therapy.

Pharmacogenomics 2018 04 27;19(6):577-587. Epub 2018 Mar 27.

Institute for Diabetes Research & Metabolic Diseases of the Helmholtz Centre Munich at the Eberhard Karls University Tübingen, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2217/pgs-2017-0195DOI Listing
April 2018

The hepatokines fetuin-A and fetuin-B are upregulated in the state of hepatic steatosis and may differently impact on glucose homeostasis in humans.

Am J Physiol Endocrinol Metab 2018 03 14;314(3):E266-E273. Epub 2017 Nov 14.

Department of Internal Medicine IV, Division of Endocrinology, Diabetology, Vascular Medicine, Nephrology and Clinical Chemistry, University of Tübingen , Tübingen , Germany.

View Article

Download full-text PDF

Source
http://www.physiology.org/doi/10.1152/ajpendo.00262.2017
Publisher Site
http://dx.doi.org/10.1152/ajpendo.00262.2017DOI Listing
March 2018

Higher prevalence of lymph node metastasis in prostate cancer in patients with diabetes.

Endocr Relat Cancer 2018 03 12;25(3):L19-L22. Epub 2018 Jan 12.

Department of Internal MedicineDivision of Endocrinology, Diabetology, Vascular Disease, Nephrology and Clinical Chemistry, University of Tübingen, Tübingen, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1530/ERC-17-0465DOI Listing
March 2018

Genome-wide analysis of PDX1 target genes in human pancreatic progenitors.

Mol Metab 2018 03 31;9:57-68. Epub 2018 Jan 31.

Institute of Diabetes and Regeneration Research, Helmholtz Zentrum München, Parkring 11, 85748, Garching, Germany; Institute of Stem Cell Research, Helmholtz Zentrum München, 85764 Neuherberg, Germany; Chair of ß-Cell Biology, Technische Universität München, Ismaningerstraße 22, 81675 München, Germany; German Center for Diabetes Research (DZD), 85764 Neuherberg, Germany. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.molmet.2018.01.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5870105PMC
March 2018

Prevalence and Distribution of Diabetes Mellitus in a Maximum Care Hospital: Urgent Need for HbA1c-Screening.

Exp Clin Endocrinol Diabetes 2018 02 27;126(2):123-129. Epub 2017 Jul 27.

Department of Internal Medicine, Division of Endocrinology, Diabetology, Vascular Medicine, Nephrology, and Clinical Chemistry, University Hospital Tuebingen, Tuebingen Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/s-0043-112653DOI Listing
February 2018

Androgen receptor overexpression in prostate cancer in type 2 diabetes.

Mol Metab 2018 02 5;8:158-166. Epub 2017 Dec 5.

Department of Internal Medicine, Division of Endocrinology, Diabetology, Vascular Disease, Nephrology and Clinical Chemistry, University of Tübingen, Germany; Institute for Diabetes Research and Metabolic Diseases (IDM), Helmholtz Center Munich, University of Tübingen, Germany; German Center for Diabetes Research (DZD), Munich-Neuherberg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.molmet.2017.11.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5985051PMC
February 2018

Identification of genetic elements in metabolism by high-throughput mouse phenotyping.

Nat Commun 2018 01 18;9(1):288. Epub 2018 Jan 18.

German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstädter Landstr. 1, 85764, Neuherberg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41467-017-01995-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5773596PMC
January 2018

Serine/threonine protein kinase 25 antisense oligonucleotide treatment reverses glucose intolerance, insulin resistance, and nonalcoholic fatty liver disease in mice.

Hepatol Commun 2018 01 20;2(1):69-83. Epub 2017 Nov 20.

Lundberg Laboratory for Diabetes Research, Department of Molecular and Clinical Medicine, Institute of Medicine University of Gothenburg, Sahlgrenska University Hospital Gothenburg Sweden.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/hep4.1128DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5776874PMC
January 2018

Excessive fuel availability amplifies the FTO-mediated obesity risk: results from the TUEF and Whitehall II studies.

Sci Rep 2017 11 14;7(1):15486. Epub 2017 Nov 14.

Department of Internal Medicine IV, Division of Endocrinology, Diabetology, Nephrology, Vascular Disease and Clinical Chemistry, University Hospital of Tübingen, Tübingen, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-017-15744-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5686126PMC
November 2017

Fibroblast Growth Factor 21-Metabolic Role in Mice and Men.

Endocr Rev 2017 10;38(5):468-488

Interfaculty Center for Pharmacogenomics and Pharma Research, Eberhard Karls University Tübingen, 72076 Tübingen, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1210/er.2017-00016DOI Listing
October 2017

Activated macrophages control human adipocyte mitochondrial bioenergetics via secreted factors.

Mol Metab 2017 10 19;6(10):1226-1239. Epub 2017 Jul 19.

Institute of Diabetes and Regeneration Research, Helmholtz Zentrum Muenchen, German Research Center for Environmental Health (GmbH), Neuherberg, Germany; German Center for Diabetes Research (DZD), Neuherberg, Germany; Medizinische Klinik und Poliklinik IV, Klinikum der LMU, 80336 München, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.molmet.2017.07.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5641636PMC
October 2017

Common variation in the sodium/glucose cotransporter 2 gene SLC5A2 does neither affect fasting nor glucose-suppressed plasma glucagon concentrations.

PLoS One 2017 4;12(5):e0177148. Epub 2017 May 4.

Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the Eberhard Karls University Tübingen, Otfried-Müller-Straße 10, Tübingen, Germany.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0177148PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5417681PMC
September 2017

Erratum to: A novel insulin sensitivity index particularly suitable to measure insulin sensitivity during gestation.

Acta Diabetol 2017 07;54(7):713-714

Department of Internal Medicine IV, Division of Endocrinology, Diabetology, Nephrology, Vascular Disease and Clinical Chemistry, University Hospital of Tübingen, Tübingen, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00592-017-1002-1DOI Listing
July 2017

Genetic determination of body fat distribution and the attributive influence on metabolism.

Obesity (Silver Spring) 2017 07 25;25(7):1277-1283. Epub 2017 May 25.

Department of Internal Medicine, Division of Endocrinology, Diabetology, Angiology, Nephrology and Clinical Chemistry, Eberhard Karls University, Tübingen, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/oby.21874DOI Listing
July 2017

Influence of common polymorphisms in the SLC5A2 gene on metabolic traits in subjects at increased risk of diabetes and on response to empagliflozin treatment in patients with diabetes.

Pharmacogenet Genomics 2017 04;27(4):135-142

aBoehringer Ingelheim Pharma GmbH & Co. KG, Biberach bGerman Center for Diabetes Research (DZD) cInstitute for Diabetes Research and Metabolic Diseases, Helmholtz Centre Munich dDepartment of Internal Medicine, Division of Endocrinology, Diabetology, Vascular Disease, Nephrology, and Clinical Chemistry eInterfaculty Centre for Pharmacogenomics and Pharma Research, University of Tuebingen fInstitute of Pharmaceutical Sciences, Department of Pharmacy and Biochemistry, Eberhard Karls University Tuebingen, Tuebingen gInstitute of Experimental Genetics, Helmholtz Centre Munich, German Research Center for Environmental Health, Neuherberg hBoehringer Ingelheim Pharma GmbH & Co. KG, Ingelheim, Germany iEli Lilly and Company, Indianapolis, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/FPC.0000000000000268DOI Listing
April 2017

Impact of fibroblast growth factor 21 on the secretome of human perivascular preadipocytes and adipocytes: a targeted proteomics approach.

Arch Physiol Biochem 2016 Dec 5;122(5):281-288. Epub 2016 Aug 5.

a Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the University of Tübingen , Tübingen , Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/13813455.2016.1212898DOI Listing
December 2016

Interaction between the obesity-risk gene FTO and the dopamine D2 receptor gene ANKK1/TaqIA on insulin sensitivity.

Diabetologia 2016 12 6;59(12):2622-2631. Epub 2016 Sep 6.

Department of Internal Medicine, Division of Endocrinology, Diabetology, Angiology, Nephrology and Clinical Chemistry, Eberhard Karls University Tübingen, Tübingen, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00125-016-4095-0DOI Listing
December 2016

Genetic Variation in the 11β-hydroxysteroid-dehydrogenase 1 Gene Determines NAFLD and Visceral Obesity.

J Clin Endocrinol Metab 2016 12 7;101(12):4743-4751. Epub 2016 Oct 7.

Department of Internal Medicine, Division of Endocrinology, Diabetology, Vascular Medicine, Nephrology, and Clinical Chemistry (S.Z.L., A.P., F.M., A.L., A.F., H.-U.H., N.S., K.K.), Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich (S.Z.L., A.P., F.M., A.L., J.M., F.S., A.F., H.S., H.-U.H., N.S., K.K.), Section on Experimental Radiology (J.M., F.S.), Department of General, Visceral, and Transplant Surgery (I.K., A.K.), and Institute of Pharmaceutical Sciences, Department of Pharmacy and Biochemistry (H.S.), University of Tübingen, D-72076 Tübingen, Germany; German Center for Diabetes Research (S.Z.L., A.P., F.M., A.L., J.M., F.S., A.F., H.S., H.-U.H., N.S., K.K.), 85764 München-Neuherberg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1210/jc.2016-2498DOI Listing
December 2016

A novel insulin sensitivity index particularly suitable to measure insulin sensitivity during gestation.

Acta Diabetol 2016 Dec 22;53(6):1037-1044. Epub 2016 Oct 22.

Department of Internal Medicine IV, Division of Endocrinology, Diabetology, Nephrology, Vascular Disease and Clinical Chemistry, University Hospital of Tübingen, Tübingen, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00592-016-0930-5DOI Listing
December 2016

TGF-β Contributes to Impaired Exercise Response by Suppression of Mitochondrial Key Regulators in Skeletal Muscle.

Diabetes 2016 10 29;65(10):2849-61. Epub 2016 Jun 29.

Division of Endocrinology, Diabetology, Angiology, Nephrology, Pathobiochemistry and Clinical Chemistry, Department of Internal Medicine IV, University Hospital Tübingen, Tübingen, Germany Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Zentrum München, University of Tübingen, Tübingen, Germany German Center for Diabetes Research (DZD), Neuherberg, Germany

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2337/db15-1723DOI Listing
October 2016

Genome-Wide Association Study of the Modified Stumvoll Insulin Sensitivity Index Identifies BCL2 and FAM19A2 as Novel Insulin Sensitivity Loci.

Diabetes 2016 10 14;65(10):3200-11. Epub 2016 Jul 14.

Diabetes Research Center (Diabetes Unit), Massachusetts General Hospital, Boston, MA Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA Department of Medicine, Harvard Medical School, Boston, MA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2337/db16-0199DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5033262PMC
October 2016

Generation of a human induced pluripotent stem cell (iPSC) line from a patient carrying a P33T mutation in the PDX1 gene.

Stem Cell Res 2016 09 5;17(2):273-276. Epub 2016 Aug 5.

Institute of Diabetes and Regeneration Research, Helmholtz Zentrum München, 85764 Neuherberg, Germany; Institute of Stem Cell Research, Helmholtz Zentrum München, 85764 Neuherberg, Germany; Technische Universität München, Ismaninger straße 22, 81675 München, Germany; German Center for Diabetes Research (DZD), 85764 Neuherberg, Germany. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.scr.2016.08.004DOI Listing
September 2016

Generation of a human induced pluripotent stem cell (iPSC) line from a patient with family history of diabetes carrying a C18R mutation in the PDX1 gene.

Stem Cell Res 2016 09 6;17(2):292-295. Epub 2016 Aug 6.

Institute of Diabetes and Regeneration Research, Helmholtz Zentrum München, 85764 Neuherberg, Germany; Institute of Stem Cell Research, Helmholtz Zentrum München, 85764 Neuherberg, Germany; Technische Universität München, Ismaninger straße 22, 81675 München, Germany; German Center for Diabetes Research (DZD), 85764 Neuherberg, Germany. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.scr.2016.08.005DOI Listing
September 2016

Early hypermethylation of hepatic Igfbp2 results in its reduced expression preceding fatty liver in mice.

Hum Mol Genet 2016 06 28;25(12):2588-2599. Epub 2016 Apr 28.

Department of Experimental Diabetology, German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE), Nuthetal, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/hmg/ddw121DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5181631PMC
June 2016

Granulocyte colony-stimulating factor (G-CSF): A saturated fatty acid-induced myokine with insulin-desensitizing properties in humans.

Mol Metab 2016 Apr 13;5(4):305-316. Epub 2016 Feb 13.

Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Centre Munich at the University of Tübingen, Tübingen, Germany; German Center for Diabetes Research (DZD), Tübingen, Germany; Department of Internal Medicine, Division of Endocrinology, Diabetology, Angiology, Nephrology and Clinical Chemistry, University Hospital Tübingen, Tübingen, Germany. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S22128778160002
Publisher Site
http://dx.doi.org/10.1016/j.molmet.2016.02.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4812007PMC
April 2016

Exercise and diabetes: relevance and causes for response variability.

Endocrine 2016 Mar 7;51(3):390-401. Epub 2015 Dec 7.

Department of Internal Medicine IV, Division of Endocrinology, Diabetology, Angiology, Nephrology, and Clinical Chemistry, University Hospital Tübingen, Eberhard Karls University Tübingen, 72076, Tübingen, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12020-015-0792-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4762932PMC
March 2016

A high-risk phenotype associates with reduced improvement in glycaemia during a lifestyle intervention in prediabetes.

Diabetologia 2015 Dec 24;58(12):2877-84. Epub 2015 Sep 24.

Department of Internal Medicine IV, Division of Endocrinology, Diabetology, Vascular Medicine, Nephrology and Clinical Chemistry, University Hospital Tübingen, Otfried-Müller-Str. 10, 72076, Tübingen, Germany.

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s00125-015-3760-z
Publisher Site
http://dx.doi.org/10.1007/s00125-015-3760-zDOI Listing
December 2015

Identification of Four Mouse Diabetes Candidate Genes Altering β-Cell Proliferation.

PLoS Genet 2015 Sep 8;11(9):e1005506. Epub 2015 Sep 8.

Department of Experimental Diabetology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany; German Center for Diabetes Research (DZD), Neuherberg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.pgen.1005506DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4562707PMC
September 2015

Fibroblast growth factor 21 is elevated in metabolically unhealthy obesity and affects lipid deposition, adipogenesis, and adipokine secretion of human abdominal subcutaneous adipocytes.

Mol Metab 2015 Jul 1;4(7):519-27. Epub 2015 May 1.

German Centre for Diabetes Research (DZD), Ingolstädter Landstraße 1, D-85764 Neuherberg, Germany ; Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Centre Munich at the University of Tübingen, Otfried-Müller-Straße 10, D-72076 Tübingen, Germany ; Department of Internal Medicine, Division of Endocrinology, Diabetology, Angiology, Nephrology and Clinical Chemistry, University Hospital Tübingen, Otfried-Müller-Straße 10, D-72076 Tübingen, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.molmet.2015.04.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4481465PMC
July 2015

Common genetic variation in the human CTF1 locus, encoding cardiotrophin-1, determines insulin sensitivity.

PLoS One 2014 15;9(7):e100391. Epub 2014 Jul 15.

Department of Internal Medicine, Division of Endocrinology, Diabetology, Vascular Disease, Nephrology and Clinical Chemistry, University of Tübingen, Tübingen, Germany; Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Centre Munich at the University of Tübingen, Tübingen, Germany; German Centre for Diabetes Research (DZD), Tübingen, Germany.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0100391PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4099130PMC
March 2015

Metabolic signatures of cultured human adipocytes from metabolically healthy versus unhealthy obese individuals.

PLoS One 2014 2;9(4):e93148. Epub 2014 Apr 2.

Helmholtz Zentrum München, German Research Center for Environmental Health, Institute of Experimental Genetics, Genome Analysis Center, Neuherberg, Germany; Department of Internal Medicine IV, Division of Endocrinology, Diabetology, Angiology, Nephrology, and Clinical Chemistry, University Hospital, Eberhard Karls University, Tübingen, Germany; German Center for Diabetes Research, Neuherberg, Germany; Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center München at the Eberhard Karls University of Tübingen, Tübingen, Germany.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0093148PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3973696PMC
February 2015

Antihyperglycaemic therapies and cancer risk.

Diab Vasc Dis Res 2014 Nov 17;11(6):371-89. Epub 2014 Sep 17.

Division of Endocrinology, Diabetology, Vascular Disease, Nephrology and Clinical Chemistry, Department of Internal Medicine, University of Tübingen, Tübingen, Germany German Centre for Diabetes Research (DZD), Tübingen, Germany Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Centre Munich at the University of Tübingen, Tübingen, Germany

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1479164114549553DOI Listing
November 2014

Peroxisome proliferator-activated receptor gamma (PPARG) modulates free fatty acid receptor 1 (FFAR1) dependent insulin secretion in humans.

Mol Metab 2014 Sep 7;3(6):676-80. Epub 2014 Jul 7.

Department of Internal Medicine, Division of Endocrinology, Diabetology, Nephrology, Vascular Disease and Clinical Chemistry, University Hospital of the Eberhard Karls University, Tübingen, Germany ; Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Centre Munich at the University of Tübingen (IDM), Tübingen, Germany ; German Center for Diabetes Research (DZD), Neuherberg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.molmet.2014.07.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4142395PMC
September 2014

Untangling the interplay of genetic and metabolic influences on beta-cell function: Examples of potential therapeutic implications involving TCF7L2 and FFAR1.

Mol Metab 2014 Jun 22;3(3):261-7. Epub 2014 Jan 22.

Department of Internal Medicine, Division of Endocrinology, Diabetology, Nephrology, Vascular Disease and Clinical Chemistry, University Hospital of the Eberhard Karls University, Tübingen, Germany ; Institute for Diabetes Research and Metabolic Diseases of the Helmholz Centre Munich at the University of Tübingen (IDM), Tübingen, Germany ; German Center for Diabetes Research (DZD), Neuherberg, Germany.

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S22128778140000
Publisher Site
http://dx.doi.org/10.1016/j.molmet.2014.01.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3986492PMC
June 2014

Variation in the obesity risk gene FTO determines the postprandial cerebral processing of food stimuli in the prefrontal cortex.

Mol Metab 2014 Apr 8;3(2):109-13. Epub 2013 Dec 8.

Department of Internal Medicine, Division of Endocrinology, Diabetology, Angiology, Nephrology and Clinical Chemistry, Eberhard Karls University Tübingen, Tübingen, Germany ; Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the University of Tübingen, Tübingen, Germany ; German Center for Diabetes Research (DZD e.V.), Neuherberg, Germany.

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S22128778130012
Publisher Site
http://dx.doi.org/10.1016/j.molmet.2013.11.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3953703PMC
April 2014

Differential effect of glucose ingestion on the neural processing of food stimuli in lean and overweight adults.

Hum Brain Mapp 2014 Mar 10;35(3):918-28. Epub 2013 Jan 10.

Division of Endocrinology, Diabetology, Angiology, Nephrology and Clinical Chemistry, Department of Internal Medicine, Eberhard Karls University Tübingen, Germany.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/hbm.22223
Publisher Site
http://dx.doi.org/10.1002/hbm.22223DOI Listing
March 2014

Polymorphism rs3123554 in CNR2 reveals gender-specific effects on body weight and affects loss of body weight and cerebral insulin action.

Obesity (Silver Spring) 2014 Mar 25;22(3):925-31. Epub 2014 Jan 25.

Department of Internal Medicine, Division of Endocrinology, Diabetology, Angiology, Nephrology, and Clinical Chemistry, Eberhard Karls University, Tübingen, Germany; Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the University of Tübingen (Paul Langerhans Institute Tübingen), Tübingen, Germany; German Center for Diabetes Research (DZD), Neuherberg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/oby.20573DOI Listing
March 2014

The Akt substrate Girdin is a regulator of insulin signaling in myoblast cells.

Biochim Biophys Acta 2013 Dec 23;1833(12):2803-2811. Epub 2013 Jul 23.

Department of Internal Medicine IV, Otfried-Müller Str.10, 72076 Tübingen, Germany. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbamcr.2013.07.012DOI Listing
December 2013

Cytokine response of primary human myotubes in an in vitro exercise model.

Am J Physiol Cell Physiol 2013 Oct 7;305(8):C877-86. Epub 2013 Aug 7.

Institute of Experimental Genetics, Helmholtz Zentrum Muenchen, German Research Center for Environmental Health, Neuherberg, Germany;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1152/ajpcell.00043.2013DOI Listing
October 2013

Nor-1, a novel incretin-responsive regulator of insulin genes and insulin secretion.

Mol Metab 2013 17;2(3):243-55. Epub 2013 Jun 17.

Department of Internal Medicine, Division of Endocrinology, Diabetology, Angiology, Nephrology and Clinical Chemistry, University Hospital Tübingen, Germany ; Institute for Diabetes Research and Metabolic Diseases of the Helmholz Centre Munich at the University of Tübingen, Germany ; German Center for Diabetes Research (DZD), Neuherberg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.molmet.2013.06.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3773820PMC
September 2013

Genetic variation in NR1H4 encoding the bile acid receptor FXR determines fasting glucose and free fatty acid levels in humans.

J Clin Endocrinol Metab 2013 Jul 2;98(7):E1224-9. Epub 2013 May 2.

Department of Internal Medicine, Division of Endocrinology, University Hospital, Eberhard Karls University Tübingen, 72076 Tübingen, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1210/jc.2013-1177DOI Listing
July 2013

Production and release of acylcarnitines by primary myotubes reflect the differences in fasting fat oxidation of the donors.

J Clin Endocrinol Metab 2013 Jun 30;98(6):E1137-42. Epub 2013 Apr 30.

Division of Endocrinology, Diabetology, Angiology, Nephrology, Pathobiochemistry, and Clinical Chemistry, Department of Internal Medicine, University Tübingen, 72076 Tübingen, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1210/jc.2012-3976DOI Listing
June 2013

Allele summation of diabetes risk genes predicts impaired glucose tolerance in female and obese individuals.

PLoS One 2012 29;7(6):e38224. Epub 2012 Jun 29.

Department of Internal Medicine, Division of Endocrinology, Diabetology, Nephrology, Vascular Disease and Clinical Chemistry, Eberhard Karls University Tübingen, Tübingen, Germany.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0038224PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3387191PMC
November 2012

Common genetic variation in the SERPINF1 locus determines overall adiposity, obesity-related insulin resistance, and circulating leptin levels.

PLoS One 2012 23;7(3):e34035. Epub 2012 Mar 23.

Department of Internal Medicine, Division of Endocrinology, Diabetology, Angiology, Nephrology and Clinical Chemistry, Eberhard Karls University Tübingen, Tübingen, Germany.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0034035PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3311576PMC
August 2012

Glucose-raising genetic variants in MADD and ADCY5 impair conversion of proinsulin to insulin.

PLoS One 2011 22;6(8):e23639. Epub 2011 Aug 22.

Department of Internal Medicine, Division of Endocrinology, Diabetology, Angiology, Nephrology and Clinical Chemistry, Eberhard Karls University Tübingen, Tübingen, Germany.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0023639PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3161735PMC
January 2012

In vitro responsiveness of human muscle cell peroxisome proliferator-activated receptor δ reflects donors' insulin sensitivity in vivo.

Eur J Clin Invest 2011 Dec 25;41(12):1323-9. Epub 2011 May 25.

Division of Endocrinology, Diabetology, Angiology, Nephrology, and Clinical Chemistry, Department of Internal Medicine, Member of the German Center for Diabetes Research (DZD e.V.), Eberhard Karls University Tübingen, Tübingen, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1365-2362.2011.02547.xDOI Listing
December 2011

Insulin promotes glycogen storage and cell proliferation in primary human astrocytes.

PLoS One 2011 27;6(6):e21594. Epub 2011 Jun 27.

Division of Endocrinology, Diabetology, Angiology, Nephrology and Clinical Chemistry, Department of Internal Medicine, Eberhard Karls University Tübingen, Tübingen, Germany.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0021594PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3124526PMC
December 2011

Genetic variation within the TRPM5 locus associates with prediabetic phenotypes in subjects at increased risk for type 2 diabetes.

Metabolism 2011 Sep 12;60(9):1325-33. Epub 2011 Apr 12.

Division of Endocrinology, Diabetology, Angiology, Nephrology, and Clinical Chemistry, Department of Internal Medicine, Eberhard Karls University Tübingen, Otfried-Müller-Str. 10, 72076 Tübingen, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.metabol.2011.02.002DOI Listing
September 2011

Variants in the CD36 gene locus determine whole-body adiposity, but have no independent effect on insulin sensitivity.

Obesity (Silver Spring) 2011 May 21;19(5):1004-9. Epub 2010 Oct 21.

Division of Endocrinology, Diabetology, Angiology, Nephrology, and Clinical Chemistry, Department of Internal Medicine, Eberhard Karls University Tübingen, Member of the German Center for Diabetes Research (DZD), Tübingen, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/oby.2010.251DOI Listing
May 2011

The myocyte expression of adiponectin receptors and PPARδ is highly coordinated and reflects lipid metabolism of the human donors.

Exp Diabetes Res 2011 27;2011:692536. Epub 2011 Jan 27.

Division of Endocrinology, Department of Internal Medicine, Eberhard Karls University Tübingen and German Center for Diabetes Research (DZD eV), Tübingen, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1155/2011/692536DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3038795PMC
May 2011

Genetic variation within the NR1H2 gene encoding liver X receptor β associates with insulin secretion in subjects at increased risk for type 2 diabetes.

J Mol Med (Berl) 2011 Jan 2;89(1):75-81. Epub 2010 Nov 2.

Division of Endocrinology, Diabetology, Angiology, Nephrology, and Clinical Chemistry, Department of Internal Medicine, Eberhard Karls University Tübingen, German Center for Diabetes Research (DZD), Otfried-Müller-Str. 10, 72076, Tübingen, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00109-010-0687-1DOI Listing
January 2011

Inflammatory response of human coronary artery endothelial cells to saturated long-chain fatty acids.

Microvasc Res 2011 Jan 26;81(1):52-9. Epub 2010 Nov 26.

Department of Internal Medicine, Division of Endocrinology, Diabetology, Angiology, Nephrology, and Clinical Chemistry, University Hospital Tübingen, Tübingen, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.mvr.2010.11.008DOI Listing
January 2011

Glycemia determines the effect of type 2 diabetes risk genes on insulin secretion.

Diabetes 2010 Dec 29;59(12):3247-52. Epub 2010 Aug 29.

Department of Internal Medicine, Division of Endocrinology, Diabetology, Angiology, Nephrology and Clinical Chemistry, Eberhard Karls University Tübingen, Tübingen, Germany.

View Article

Download full-text PDF

Source
http://diabetes.diabetesjournals.org/cgi/doi/10.2337/db10-06
Publisher Site
http://dx.doi.org/10.2337/db10-0674DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2992789PMC
December 2010

Relationships of circulating sex hormone-binding globulin with metabolic traits in humans.

Diabetes 2010 Dec 14;59(12):3167-73. Epub 2010 Sep 14.

Department of Internal Medicine, Division of Endocrinology, Diabetology, Vascular Medicine, Nephrology and Clinical Chemistry, University of Tübingen, Tübingen, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2337/db10-0179DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2992779PMC
December 2010

Evaluation of fasting state-/oral glucose tolerance test-derived measures of insulin release for the detection of genetically impaired β-cell function.

PLoS One 2010 Dec 2;5(12):e14194. Epub 2010 Dec 2.

Division of Endocrinology, Diabetology, Angiology, Nephrology, and Clinical Chemistry, Department of Internal Medicine, University Hospital Tübingen and Eberhard Karls University Tübingen, Tübingen, Germany.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0014194PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2996282PMC
December 2010

The D299G/T399I Toll-like receptor 4 variant associates with body and liver fat: results from the TULIP and METSIM Studies.

PLoS One 2010 Nov 15;5(11):e13980. Epub 2010 Nov 15.

Division of Endocrinology, Diabetology, Vascular Disease, Nephrology, Clinical Chemistry, Department of Internal Medicine, Paul-Langerhans-Institute Tübingen, University of Tübingen, Tübingen, Germany.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0013980PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2981584PMC
November 2010

Interscapular fat is strongly associated with insulin resistance.

J Clin Endocrinol Metab 2010 Oct 21;95(10):4736-42. Epub 2010 Jul 21.

Department of Internal Medicine, Division of Endocrinology, Diabetology, Vascular Medicine, Nephrology, and Clinical Chemistry, Eberhard Karls University, Tübingen, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1210/jc.2009-1942DOI Listing
October 2010

Genetic variants in MTNR1B affecting insulin secretion.

Ann Med 2010 Sep;42(6):387-93

Division of Endocrinology, Diabetology, Angiology, Nephrology, and Clinical Chemistry, Department of Internal Medicine, Eberhard Karls University, Member of the German Centre for Diabetes Research (DZD), 72076 Tübingen, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3109/07853890.2010.502125DOI Listing
September 2010

Novel obesity risk loci do not determine distribution of body fat depots: a whole-body MRI/MRS study.

Obesity (Silver Spring) 2010 Jun 12;18(6):1212-7. Epub 2009 Nov 12.

Department of Internal Medicine, Division of Endocrinology, Diabetology, Angiology, Nephrology and Clinical Chemistry, Eberhard-Karls-University Tübingen, Tübingen, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/oby.2009.413DOI Listing
June 2010

No association between variation in the NR4A1 gene locus and metabolic traits in white subjects at increased risk for type 2 diabetes.

BMC Med Genet 2010 Jun 4;11:84. Epub 2010 Jun 4.

Division of Endocrinology, Diabetology, Angiology, Nephrology, and Clinical Chemistry, Department of Internal Medicine, University Hospital of Tübingen, Otfried-Müller-Str, 10, 72076 Tübingen, Germany.

View Article

Download full-text PDF

Source
http://bmcmedgenet.biomedcentral.com/articles/10.1186/1471-2
Publisher Site
http://dx.doi.org/10.1186/1471-2350-11-84DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2894787PMC
June 2010

Association of obesity risk SNPs in PCSK1 with insulin sensitivity and proinsulin conversion.

BMC Med Genet 2010 Jun 9;11:86. Epub 2010 Jun 9.

Department of Internal Medicine, Division of Endocrinology, Eberhard Karls University Tübingen, Member of the German Centre for Diabetes Research DZD, Tübingen, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/1471-2350-11-86DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2898666PMC
June 2010

Gene variants of TCF7L2 influence weight loss and body composition during lifestyle intervention in a population at risk for type 2 diabetes.

Diabetes 2010 Mar 22;59(3):747-50. Epub 2009 Dec 22.

Department of Internal Medicine, Division of Endocrinology, Diabetology, Angiology, Nephrology and Clinical Chemistry, Eberhard-Karls-University Tübingen, Tübingen, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2337/db09-1050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2828665PMC
March 2010

Pancreatic fat is negatively associated with insulin secretion in individuals with impaired fasting glucose and/or impaired glucose tolerance: a nuclear magnetic resonance study.

Diabetes Metab Res Rev 2010 Mar;26(3):200-5

Department of Internal Medicine, Division of Endocrinology, Diabetology, Angiology, Nephrology, and Clinical Chemistry, Eberhard-Karls-University Tübingen, Tübingen, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/dmrr.1073DOI Listing
March 2010

Circulating palmitoleate strongly and independently predicts insulin sensitivity in humans.

Diabetes Care 2010 Feb 4;33(2):405-7. Epub 2009 Nov 4.

Department of Internal Medicine, Division of Endocrinology, Diabetology, Vascular Medicine, Nephrology and Clinical Chemistry, University of Tübingen, Tübingen, Germany.

View Article

Download full-text PDF

Source
http://care.diabetesjournals.org/cgi/doi/10.2337/dc09-0544
Publisher Site
http://dx.doi.org/10.2337/dc09-0544DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2809292PMC
February 2010

Pathomechanisms of type 2 diabetes genes.

Endocr Rev 2009 Oct 11;30(6):557-85. Epub 2009 Sep 11.

Department of Internal Medicine, Division of Endocrinology, Diabetology, Angiology, Nephrology, and Clinical Chemistry, University Hospital Tübingen, D-72076 Tübingen, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1210/er.2009-0017DOI Listing
October 2009