Harald Hegen

Harald Hegen

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Harald Hegen

Harald Hegen

Publications by authors named "Harald Hegen"

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International multicenter examination of MOG antibody assays.

Neurol Neuroimmunol Neuroinflamm 2020 Mar 5;7(2). Epub 2020 Feb 5.

From the Clinical Department of Neurology (M. Reindl, K.S., M. Ramberger, H.H.), Medical University of Innsbruck, Innsbruck, Austria; Oxford Autoimmune Neurology Group (M.W., M. Ramberger, M.I.L., J.P., S.R.I., P.W.), Nuffield Department of Clinical Neurosciences, University of Oxford, United Kingdom; Brain Autoimmunity Group (F.T., S.R., R.C.D., F.B.), Kids Neuroscience Centre at Kids Research at the Children's Hospital at Westmead, Brain and Mind Centre, University of Sydney, New South Wales, Australia; Department of Neurology (J.S., J.P.F., J.M., E.P.F., S.J.P.), Mayo Clinic, Rochester, MN; Euroimmun Medizinische Labordiagnostika AG (B.T., S.M., N.R., U.K., W.S., C.P.), Lübeck, Germany; Institute for Quality Assurance (ifQ) affiliated to Euroimmun (J.E., M.P.), Lübeck, Germany; Paediatric Neurology (K.R.), Witten/Herdecke University, Children's Hospital Datteln, Datteln, Germany; and Department of Neurology (T.B.), Medical University of Vienna, Austria.

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http://dx.doi.org/10.1212/NXI.0000000000000674DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7051197PMC
March 2020

Pregnancy and multiple sclerosis in the DMT era: A cohort study in Western Austria.

Mult Scler 2020 01 3;26(1):69-78. Epub 2018 Dec 3.

Clinical Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.

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http://dx.doi.org/10.1177/1352458518816614DOI Listing
January 2020

Commentary to "Letter to the editor: To treat or not to treat study - Comparative group inclusion considerations" for multiple sclerosis and related disorders.

Mult Scler Relat Disord 2020 Jan 31;40:101975. Epub 2020 Jan 31.

Department of Neurology, Medical University of Vienna, Austria.

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http://dx.doi.org/10.1016/j.msard.2020.101975DOI Listing
January 2020

To treat or not to treat: Sequential individualized treatment evaluation in relapsing multiple sclerosis.

Mult Scler Relat Disord 2019 Dec 23;39:101908. Epub 2019 Dec 23.

Department of Neurology, Medical University of Vienna, Austria.

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http://dx.doi.org/10.1016/j.msard.2019.101908DOI Listing
December 2019

Serum hepcidin levels in multiple sclerosis.

Mult Scler J Exp Transl Clin 2019 Oct-Dec;5(4):2055217319885984. Epub 2019 Nov 4.

Department of Neurology, Medical University of Vienna, Austria.

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http://dx.doi.org/10.1177/2055217319885984DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6831977PMC
November 2019

Free light chains in the cerebrospinal fluid. Comparison of different methods to determine intrathecal synthesis.

Clin Chem Lab Med 2019 Sep;57(10):1574-1586

Department of Neurology, Wilhelminenspital, Montleartstrasse 37, 1160 Vienna, Austria.

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http://dx.doi.org/10.1515/cclm-2018-1300DOI Listing
September 2019

A Survey of Cerebrospinal Fluid Total Protein Upper Limits in Canada: Time for an Update?

Can J Neurol Sci 2019 05 27;46(3):283-286. Epub 2019 Mar 27.

Division of Neurology, Department of Medicine,The Ottawa Hospital and University of Ottawa,Ottawa, Ontario,Canada.

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http://dx.doi.org/10.1017/cjn.2019.12DOI Listing
May 2019

Dataset for worldwide survey of cerebrospinal total protein upper reference values.

Data Brief 2019 Apr 7;23:103760. Epub 2019 Mar 7.

Division of Neurology, Department of Medicine, The Ottawa Hospital and University of Ottawa, Ottawa, Ontario, Canada.

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http://dx.doi.org/10.1016/j.dib.2019.103760DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6514267PMC
April 2019

Adult CSF total protein upper reference limits should be age-partitioned and significantly higher than 0.45 g/L: a systematic review.

J Neurol 2019 Mar 8;266(3):616-624. Epub 2019 Jan 8.

Division of Neurology, Department of Medicine, The Ottawa Hospital and University of Ottawa, 1053 Carling Ave., Ottawa, ON, K1Y 4E9, Canada.

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http://dx.doi.org/10.1007/s00415-018-09174-zDOI Listing
March 2019

Impairment of odor discrimination and identification is associated with disability progression and gray matter atrophy of the olfactory system in MS.

Mult Scler 2019 Mar 21:1352458519838205. Epub 2019 Mar 21.

Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria/Neuroimaging Research Core Facility, Medical University of Innsbruck, Innsbruck, Austria.

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http://dx.doi.org/10.1177/1352458519838205DOI Listing
March 2019

Change of olfactory function as a marker of inflammatory activity and disability progression in MS.

Mult Scler 2019 02 29;25(2):267-274. Epub 2017 Nov 29.

Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria/Department of Neurology, University Hospital Zurich, Zurich, Switzerland; University of Zurich, Zurich, Switzerland.

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http://dx.doi.org/10.1177/1352458517745724DOI Listing
February 2019

Adult CSF total protein: Higher upper reference limits should be considered worldwide. A web-based survey.

J Neurol Sci 2019 01 3;396:48-51. Epub 2018 Nov 3.

Department of Pathology & Laboratory Medicine, The Ottawa Hospital and University of Ottawa, Ontario, Canada.

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http://dx.doi.org/10.1016/j.jns.2018.10.033DOI Listing
January 2019

Cerebrospinal fluid free light chains as diagnostic biomarker in neuroborreliosis.

Clin Chem Lab Med 2018 07;56(8):1383-1391

Department of Neurology, Wilhelminenspital, Vienna, Austria.

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http://dx.doi.org/10.1515/cclm-2018-0028DOI Listing
July 2018

Transient impairment of olfactory threshold in acute multiple sclerosis relapse.

Mult Scler Relat Disord 2018 Jul 26;23:74-77. Epub 2018 May 26.

Department of Neurology, Medical University of Innsbruck, Austria.

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http://dx.doi.org/10.1016/j.msard.2018.05.006DOI Listing
July 2018

Utility of Two-Dimensional Difference Gel Electrophoresis in Diagnosis of Multiple Sclerosis.

Diagnostics (Basel) 2018 Jul 5;8(3). Epub 2018 Jul 5.

Department of Neurology, Medical University of Innsbruck, Innrain 66, 6020 Innsbruck, Austria.

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http://dx.doi.org/10.3390/diagnostics8030044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6164878PMC
July 2018

Vascular diseases and bleedings.

Handb Clin Neurol 2017 ;146:207-236

Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.

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http://dx.doi.org/10.1016/B978-0-12-804279-3.00013-7DOI Listing
June 2018

Smoking is not associated with higher prevalence of JC virus in MS patients.

Eur J Clin Microbiol Infect Dis 2018 May 8;37(5):907-910. Epub 2018 Feb 8.

Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.

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http://dx.doi.org/10.1007/s10096-018-3204-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5916978PMC
May 2018

Discontinuation of disease-modifying therapies in multiple sclerosis - Clinical outcome and prognostic factors.

Mult Scler 2017 Aug 20;23(9):1241-1248. Epub 2016 Oct 20.

Clinical Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.

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http://dx.doi.org/10.1177/1352458516675751DOI Listing
August 2017

Persistency of Neutralizing Anti-Interferon-β Antibodies in Patients with Multiple Sclerosis Treated with Subcutaneous Interferon-β Depends on Antibody Titers, IgG Subclasses, and Affinity Maturation.

J Interferon Cytokine Res 2017 07 18;37(7):317-324. Epub 2017 Apr 18.

1 Department of Neurology, Medical University of Innsbruck , Innsbruck, Austria .

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http://dx.doi.org/10.1089/jir.2016.0080DOI Listing
July 2017

Ocrelizumab in Primary Progressive and Relapsing Multiple Sclerosis.

N Engl J Med 2017 04;376(17):1693-4

Medical University of Innsbruck, Innsbruck, Austria

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http://dx.doi.org/10.1056/NEJMc1702076DOI Listing
April 2017

Serum Cotinine Does Not Predict Neutralizing Antibodies Against Interferon Beta in an Austrian MS Cohort.

J Interferon Cytokine Res 2016 12 19;36(12):667-670. Epub 2016 Oct 19.

1 Innsbruck Medical University , Department of Neurology, Innsbruck, Austria .

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http://dx.doi.org/10.1089/jir.2016.0054DOI Listing
December 2016

Predictors of Response to Multiple Sclerosis Therapeutics in Individual Patients.

Drugs 2016 Oct;76(15):1421-1445

Department of Neurology, Medical University of Innsbruck, Anichstraße 35, 6020, Innsbruck, Austria.

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http://dx.doi.org/10.1007/s40265-016-0639-3DOI Listing
October 2016

Rethinking the importance of paroxysmal and unusual symptoms as first clinical manifestation of multiple sclerosis: They do matter.

Mult Scler Relat Disord 2016 Sep 27;9:150-4. Epub 2016 Jul 27.

Clinical Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.

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http://dx.doi.org/10.1016/j.msard.2016.07.014DOI Listing
September 2016

Bi-insular cortical involvement in anti-NMDA-receptor encephalitis - a case report.

BMC Neurol 2016 Aug 8;16:130. Epub 2016 Aug 8.

Department of Neurology, Medical University of Innsbruck, Anichstrasse 35, A-6020, Innsbruck, Austria.

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http://dx.doi.org/10.1186/s12883-016-0653-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4977643PMC
August 2016

Pharmacokinetic considerations in the treatment of multiple sclerosis with interferon-β.

Expert Opin Drug Metab Toxicol 2015 30;11(12):1803-19. Epub 2015 Sep 30.

b 2 Innsbruck Medical University, Department of Neurology, Neuroimmunology Laboratory , Innsbruck, Austria +43 5 12 50 42 42 64 ; +43 5 12 50 42 42 66 ;

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http://www.tandfonline.com/doi/full/10.1517/17425255.2015.10
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http://dx.doi.org/10.1517/17425255.2015.1094055DOI Listing
July 2016

Cytokine profiles show heterogeneity of interferon-β response in multiple sclerosis patients.

Neurol Neuroimmunol Neuroinflamm 2016 Apr 27;3(2):e202. Epub 2016 Jan 27.

Department of Neurology (H.H., A.M., M.H., D.R., F.D.), Medical University of Innsbruck, Austria; Department of Arthritis and Clinical Immunology (I.A., C.J.L., R.C.A.), Oklahoma Medical Research Foundation, Oklahoma City; Centro di Riferimento Regionale Sclerosi Multipla (A.B., S.N.), Neurologia 2, Azienda Ospedaliero Universitaria San Luigi Gonzaga, Orbassano, Turin, Italy; Centre d'Esclerosi Múltiple de Catalunya (Cemcat) (M.C., X.M.), Unitat de Neuroimmunologia Clínica, Hospital Universitari Vall d'Hebron, Barcelona, Spain; Queen Mary University London (G.G.), Blizard Institute, Barts and The London School of Medicine and Dentistry, London, UK; Clinical Department of Neurology (M.G.), Allgemeines Krankenhaus Linz, Austria; Department of Neurology (M.K., F.F.), Medical University of Graz, Austria; Department of Neurology (J.K.), Vrije Universiteit Medical Center, Amsterdam, the Netherlands; Department of Biomedicines and Neurology (R.L.P.L., M.M.), Clinical Neuroimmunology, University of Basel, University Hospital Basel, Switzerland; Clinical Department of Neurology (F. Schautzer), Landeskrankenhaus Villach, Austria; Danish Multiple Sclerosis Center (F. Sellebjerg, P.S.S.), Department of Neurology, Rigshospitalet, University of Copenhagen, Denmark; and Department of Neurology and Neurological Sciences (L.S.), Stanford University School of Medicine, CA.

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http://dx.doi.org/10.1212/NXI.0000000000000202DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4747480PMC
April 2016

Impact of glatiramer acetate on paraclinical markers of neuroprotection in multiple sclerosis: A prospective observational clinical trial.

J Neuroimmunol 2015 Oct 10;287:98-105. Epub 2015 Aug 10.

Clinical Department of Neurology, Medical University of Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria; Clinics for Neurological Rehabilitation Münster, Groeben 700, 6232 Münster, Austria; Department of Radiology, Medical University Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria. Electronic address:

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http://dx.doi.org/10.1016/j.jneuroim.2015.08.004DOI Listing
October 2015

Clinical and immunological follow-up of B-cell depleting therapy in CNS demyelinating diseases.

J Neurol Sci 2013 May 21;328(1-2):77-82. Epub 2013 Mar 21.

Clinical Department of Neurology, Innsbruck Medical University, Innsbruck, Austria.

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http://dx.doi.org/10.1016/j.jns.2013.02.024DOI Listing
May 2013

Persistency of neutralizing antibodies depends on titer and interferon-beta preparation.

Mult Scler 2012 May 19;18(5):610-5. Epub 2011 Oct 19.

Clinical Department of Neurology, Innsbruck Medical University, Innsbruck, Austria.

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http://dx.doi.org/10.1177/1352458511426738DOI Listing
May 2012

Proteomic biomarker discovery in cerebrospinal fluid for cerebral vasospasm following subarachnoid hemorrhage.

J Stroke Cerebrovasc Dis 2012 Jan 19;21(1):30-41. Epub 2010 Sep 19.

Department of Neurosurgery, Stanford University School of Medicine, Stanford, California, USA.

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http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2010.04.004DOI Listing
January 2012

Natalizumab treatment reduces endothelial activity in MS patients.

J Neuroimmunol 2010 Oct 23;227(1-2):190-4. Epub 2010 Aug 23.

Department of Neurology, Innsbruck Medical University, Anichstrasse 35, 6020 Innsbruck, Austria.

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http://dx.doi.org/10.1016/j.jneuroim.2010.07.012DOI Listing
October 2010