Harald Burkhardt

Harald Burkhardt

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Harald Burkhardt

Harald Burkhardt

Publications by authors named "Harald Burkhardt"

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ADAM15 in Apoptosis Resistance of Synovial Fibroblasts: Converting Fas/CD95 Death Signals Into the Activation of Prosurvival Pathways by Calmodulin Recruitment.

Arthritis Rheumatol 2019 Jan 20;71(1):63-72. Epub 2018 Nov 20.

University Hospital Frankfurt, Goethe University, and Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Frankfurt am Main, Germany.

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http://dx.doi.org/10.1002/art.40667DOI Listing
January 2019

High-sensitive troponin is associated with subclinical imaging biosignature of inflammatory cardiovascular involvement in systemic lupus erythematosus.

Ann Rheum Dis 2018 Nov 4;77(11):1590-1598. Epub 2018 Aug 4.

Institute of Experimental and Translational Cardiac Imaging, DZHK Centre for Cardiovascular Imaging, Goethe University Hospital Frankfurt, Frankfurt am Main, Germany.

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http://dx.doi.org/10.1136/annrheumdis-2018-213661DOI Listing
November 2018

Mannan-induced Nos2 in macrophages enhances IL-17-driven psoriatic arthritis by innate lymphocytes.

Sci Adv 2018 05 16;4(5):eaas9864. Epub 2018 May 16.

Medical Inflammation Research, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm 171 77, Sweden.

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http://dx.doi.org/10.1126/sciadv.aas9864DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5955621PMC
May 2018

The sneaking ligand approach for cell type-specific modulation of intracellular signalling pathways.

Clin Immunol 2018 01 1;186:14-20. Epub 2017 Sep 1.

Department of Rheumatology and Clinical Immunology, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.clim.2017.08.018DOI Listing
January 2018

GM-CSF in murine psoriasiform dermatitis: Redundant and pathogenic roles uncovered by antibody-induced neutralization and genetic deficiency.

PLoS One 2017 4;12(8):e0182646. Epub 2017 Aug 4.

Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Project Group Translational Medicine & Pharmacology TMP, Goethe University, Frankfurt am Main, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0182646PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5544216PMC
October 2017

Association of Improvement in Pain With Therapeutic Response as Determined by Individual Improvement Criteria in Patients With Rheumatoid Arthritis.

Arthritis Care Res (Hoboken) 2016 11 1;68(11):1607-1615. Epub 2016 Oct 1.

Schwerpunkt Rheumatologie/Klinische Immunologie Medizinische Klinik und Poliklinik II, Universität Würzburg, Würzburg, Germany.

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http://dx.doi.org/10.1002/acr.22884DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5129502PMC
November 2016

Anti-citrullinated protein antibodies are linked to erosive disease in an observational study of patients with psoriatic arthritis.

Rheumatology (Oxford) 2016 Oct 21;55(10):1791-5. Epub 2016 Jun 21.

Division of Rheumatology, University Hospital Frankfurt, Goethe University Project Group Translational Medicine & Pharmacology TMP, Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Frankfurt am Main

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http://dx.doi.org/10.1093/rheumatology/kew229DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5034218PMC
October 2016

Replication of a distinct psoriatic arthritis risk variant at the IL23R locus.

Ann Rheum Dis 2016 07 25;75(7):1417-8. Epub 2016 Mar 25.

Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, The University of Manchester, UK NIHR Manchester Musculoskeletal Biomedical Research Unit, Central Manchester Foundation Trust and University of Manchester, Manchester Academy of Health Sciences, Manchester, UK The Kellgren Centre for Rheumatology, Central Manchester Foundation Trust, NIHR Manchester Biomedical Research Centre, Manchester, UK.

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http://dx.doi.org/10.1136/annrheumdis-2016-209290DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4941176PMC
July 2016

Does Concomitant Methotrexate with Adalimumab Influence Treatment Outcomes in Patients with Psoriatic Arthritis? Data from a Large Observational Study.

J Rheumatol 2016 Mar 15;43(3):632-9. Epub 2015 Dec 15.

From the Division of Rheumatology, University Hospital Frankfurt, Goethe University, Frankfurt am Main; Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Project Group Translational Medicine and Pharmacology TMP, Frankfurt am Main; Rheumapraxis Hofheim, Hofheim; AbbVie Deutschland GmbH and Co. KG, Wiesbaden; Comprehensive Center of Inflammation Medicine, University Hospital Schleswig-Holstein Campus, Luebeck; and Schwerpunkt Rheumatologie/Klinische Immunologie Medizinische Klinik und Poliklinik II, Universität Würzburg, Würzburg, Germany.F. Behrens, MD, Division of Rheumatology, University Hospital Frankfurt, Goethe University, and Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Project Group Translational Medicine and Pharmacology TMP; M. Koehm, MD, Division of Rheumatology, University Hospital Frankfurt, Goethe University, and Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Project Group Translational Medicine and Pharmacology TMP; H. Burkhardt, MD, Division of Rheumatology, University Hospital Frankfurt, Goethe University, and Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Project Group Translational Medicine and Pharmacology TMP; U. Arndt, MD, Rheumapraxis Hofheim; B.M. Wittig, MD, AbbVie Deutschland GmbH and Co. KG; G. Greger, PhD, AbbVie Deutschland GmbH and Co. KG; D. Thaçi, MD, Comprehensive Center of Inflammation Medicine, University Hospital Schleswig-Holstein Campus; E. Scharbatke, MD; H.P. Tony, MD, Schwerpunkt Rheumatologie/Klinische Immunologie Medizinische Klinik und Poliklinik II, Universität Würzburg.

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http://dx.doi.org/10.3899/jrheum.141596DOI Listing
March 2016

Anti-TNFα-therapy as an evidence-based treatment option for different clinical manifestations of psoriatic arthritis.

Clin Exp Rheumatol 2015 Sep-Oct;33(5 Suppl 93):S109-14. Epub 2015 Oct 15.

Rheumatology Department, Goethe-University Frankfurt am Main; and Fraunhofer IME, Projectgroup Translational Medicine and Pharmacology TMP at Goethe-University Frankfurt am Main, Germany.

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December 2015

The "sneaking-ligand" approach: cell-type specific inhibition of the classical NF-κB pathway.

Methods Mol Biol 2015 ;1280:559-78

Department of Rheumatology and Clinical Immunology and Centre of Chronic Immunodeficiency, University Medical Centre and University of Freiburg, Hugstetter Street 55, Freiburg, 79106, Germany,

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http://link.springer.com/10.1007/978-1-4939-2422-6_33
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http://dx.doi.org/10.1007/978-1-4939-2422-6_33DOI Listing
November 2015

Sneaking-ligand fusion proteins attenuate serum transfer arthritis by endothelium-targeted NF-κB inhibition.

Methods Mol Biol 2015 ;1280:579-91

Department of Rheumatology and Clinical Immunology and Centre of Chronic Immunodeficiency, University Medical Centre and University of Freiburg, Hugstetter Street 55, 79106, Freiburg, Germany,

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http://dx.doi.org/10.1007/978-1-4939-2422-6_34DOI Listing
November 2015

PTPN22 is associated with susceptibility to psoriatic arthritis but not psoriasis: evidence for a further PsA-specific risk locus.

Ann Rheum Dis 2015 Oct 28;74(10):1882-5. Epub 2015 Apr 28.

Arthritis Research UK Centre for Epidemiology, Centre for Musculoskeletal Research, Institute for Inflammation and Repair, Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK NIHR Manchester Musculoskeletal Biomedical Research Unit, Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK The Kellgren Centre for Rheumatology, Central Manchester Foundation Trust, NIHR Manchester Biomedical Research Centre, Manchester, UK.

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http://dx.doi.org/10.1136/annrheumdis-2014-207187DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4602265PMC
October 2015

Association between skin and joint involvement in patients with psoriatic arthritis treated with adalimumab: analysis of data from a German non-interventional study.

Dermatology 2015 27;230(3):213-21. Epub 2015 Jan 27.

Comprehensive Center for Inflammation Medicine, University Hospital Schleswig-Holstein Campus Lübeck, Lübeck, Germany.

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http://dx.doi.org/10.1159/000371546DOI Listing
September 2015

Dense genotyping of immune-related susceptibility loci reveals new insights into the genetics of psoriatic arthritis.

Nat Commun 2015 Feb 5;6:6046. Epub 2015 Feb 5.

1] Arthritis Research UK Centre for Genetics and Genomics, The University of Manchester, Manchester M13 9PT, UK [2] NIHR Manchester Musculoskeletal Biomedical Research Unit, Central Manchester Foundation Trust and University of Manchester, Manchester Academy of Health Sciences, Manchester M13 9WU, UK.

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http://dx.doi.org/10.1038/ncomms7046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4327416PMC
February 2015

Autoimmune priming, tissue attack and chronic inflammation - the three stages of rheumatoid arthritis.

Eur J Immunol 2014 Jun 3;44(6):1593-9. Epub 2014 May 3.

Department of Medical Biochemistry and Biophysics, Medical Inflammation Research, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1002/eji.201444486DOI Listing
June 2014

ADAM15 adds to apoptosis resistance of synovial fibroblasts by modulating focal adhesion kinase signaling.

Arthritis Rheum 2013 Nov;65(11):2826-34

Johann Wolfgang Goethe University, Frankfurt am Main, Germany.

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http://dx.doi.org/10.1002/art.38109DOI Listing
November 2013

NF-κB inhibitor targeted to activated endothelium demonstrates a critical role of endothelial NF-κB in immune-mediated diseases.

Proc Natl Acad Sci U S A 2013 Oct 23;110(41):16556-61. Epub 2013 Sep 23.

Department of Rheumatology and Clinical Immunology and Centre of Chronic Immunodeficiency, University Medical Centre and University of Freiburg, 79106 Freiburg, Germany.

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http://dx.doi.org/10.1073/pnas.1218219110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3799326PMC
October 2013

Leflunomide in psoriatic arthritis: results from a large European prospective observational study.

Arthritis Care Res (Hoboken) 2013 Mar;65(3):464-70

CIRI/Division of Rheumatology, Johann Wolfgang Goethe-University, Frankfurt, Germany.

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http://dx.doi.org/10.1002/acr.21848DOI Listing
March 2013

ADAM15 protein amplifies focal adhesion kinase phosphorylation under genotoxic stress conditions.

J Biol Chem 2012 Jun 27;287(25):21214-23. Epub 2012 Apr 27.

Division of Rheumatology, Goethe University Hospital Frankfurt am Main, 60590 Frankfurt am Main, Germany.

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http://dx.doi.org/10.1074/jbc.M112.347120DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3375543PMC
June 2012

Identification of low-frequency TRAF3IP2 coding variants in psoriatic arthritis patients and functional characterization.

Arthritis Res Ther 2012 Apr 18;14(2):R84. Epub 2012 Apr 18.

Divisions of Rheumatology, Department of Internal Medicine II, Johann Wolfgang Goethe University, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany.

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http://dx.doi.org/10.1186/ar3807DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3446458PMC
April 2012

Crystal structure of an arthritogenic anticollagen immune complex.

Arthritis Rheum 2011 Dec;63(12):3740-8

Karolinska Institute, Stockholm, Sweden.

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http://dx.doi.org/10.1002/art.30611DOI Listing
December 2011

Update 2011: leflunomide in rheumatoid arthritis - strengths and weaknesses.

Curr Opin Rheumatol 2011 May;23(3):282-7

Division of Rheumatology, University Hospital Frankfurt/Main, Johann Wolfgang Goethe-University Hospital, Frankfurt/Main, Germany.

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http://dx.doi.org/10.1097/BOR.0b013e328344fddbDOI Listing
May 2011

Antibodies to the endoplasmic reticulum-resident chaperones calnexin, BiP and Grp94 in patients with rheumatoid arthritis and systemic lupus erythematosus.

Rheumatology (Oxford) 2010 Dec 17;49(12):2255-63. Epub 2010 Aug 17.

IZKF Research Group 2, Nikolaus Fiebiger Centre of Molecular Medicine, Department of Internal Medicine 3 and Institute for Clinical Immunology, Friedrich-Alexander-University Erlangen-Nuremberg, 91054 Erlangen, Germany.

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http://dx.doi.org/10.1093/rheumatology/keq272DOI Listing
December 2010

Deletion of LCE3C and LCE3B genes at PSORS4 does not contribute to susceptibility to psoriatic arthritis in German patients.

Ann Rheum Dis 2010 May 12;69(5):876-8. Epub 2009 May 12.

Institute of Human Genetics, University Hospital Erlangen, University of Erlangen-Nuremberg, 91054 Erlangen, Germany.

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http://dx.doi.org/10.1136/ard.2009.108951DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2925148PMC
May 2010

Negative association of the chemokine receptor CCR5 d32 polymorphism with systemic inflammatory response, extra-articular symptoms and joint erosion in rheumatoid arthritis.

Arthritis Res Ther 2009 18;11(3):R91. Epub 2009 Jun 18.

Division of Rheumatology, Department of Internal Medicine II, University of Leipzig, Johannisallee 30, 04103 Leipzig, Germany.

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http://dx.doi.org/10.1186/ar2733DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2714147PMC
March 2010

Antibodies to citrullinated proteins: molecular interactions and arthritogenicity.

Immunol Rev 2010 Jan;233(1):9-33

Medical Inflammation Research, Karolinska Institute, Stockholm, Sweden.

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http://dx.doi.org/10.1111/j.0105-2896.2009.00853.xDOI Listing
January 2010

ADAM15 modulates outside-in signalling in chondrocyte-matrix interactions.

J Cell Mol Med 2009 Aug;13(8B):2634-44

Division of Rheumatology, Johann Wolfgang Goethe University, Frankfurt am Main, Germany.

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http://dx.doi.org/10.1111/j.1582-4934.2008.00490.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6512361PMC
August 2009

Genetic variants of the IL-23R pathway: association with psoriatic arthritis and psoriasis vulgaris, but no specific risk factor for arthritis.

J Invest Dermatol 2009 Feb 18;129(2):355-8. Epub 2008 Sep 18.

Institute of Human Genetics, University Hospital Erlangen, University Erlangen-Nuremberg, Erlangen, Germany.

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http://dx.doi.org/10.1038/jid.2008.233DOI Listing
February 2009

Collagen type II is recognized by a pathogenic antibody through germline encoded structures.

Eur J Immunol 2008 Oct;38(10):2784-95

Division of Rheumatology, Johann Wolfgang Goethe University, Frankfurt am Main, Germany.

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http://dx.doi.org/10.1002/eji.200838238DOI Listing
October 2008

The crystal structure of the pathogenic collagen type II-specific mouse monoclonal antibody CIIC1 Fab: structure to function analysis.

Mol Immunol 2008 Apr 1;45(8):2196-204. Epub 2008 Feb 1.

Department of Molecular Biophysics, Lund University, Chemical Center, Box 124, SE 221 00, Lund, Sweden.

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http://dx.doi.org/10.1016/j.molimm.2007.12.005DOI Listing
April 2008

Modulation of granulocyte-endothelium interactions by antileukoproteinase: inhibition of anti-type II collagen antibody-induced leukocyte attachment to the synovial endothelium.

Arthritis Res Ther 2006 ;8(4):R95

Department of Internal Medicine III and Institute of Clinical Immunology, Friedrich-Alexander-University of Erlangen-Nürnberg, Krankenhausstrasse 12, 91054 Erlangen, Germany.

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http://dx.doi.org/10.1186/ar1973DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1779410PMC
February 2007

Association of the IL4R single-nucleotide polymorphism I50V with rapidly erosive rheumatoid arthritis.

Arthritis Rheum 2006 May;54(5):1491-500

Nikolaus Fiebiger Center for Molecular Medicine, Clinical Research Group III, University of Erlangen-Nuremberg, Germany.

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http://dx.doi.org/10.1002/art.21832DOI Listing
May 2006

Humoral immune response to citrullinated collagen type II determinants in early rheumatoid arthritis.

Eur J Immunol 2005 May;35(5):1643-52

Department of Internal Medicine III and Institute of Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany.

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http://dx.doi.org/10.1002/eji.200526000DOI Listing
May 2005

Homeostatic effects of the metalloproteinase disintegrin ADAM15 in degenerative cartilage remodeling.

Arthritis Rheum 2005 Apr;52(4):1100-9

Friedrich-Alexander University of Erlangen-Nuremberg, Erlangen, Germany.

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http://dx.doi.org/10.1002/art.20974DOI Listing
April 2005

[The pathologic basis: pathogenesis of rheumatoid arthritis].

Pharm Unserer Zeit 2003 ;32(5):368-74

Medizinische Klinik III mit Poliklinik, Institut für Klinische Immunologie Friedrich-Alexander-Universität Erlangen-Nürnberg Krankenhausstr. 12 91054 Erlangen.

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http://dx.doi.org/10.1002/pauz.200300035DOI Listing
October 2003