Publications by authors named "Harald Binder"

100Publications

Introduction to statistical simulations in health research.

BMJ Open 2020 Dec 13;10(12):e039921. Epub 2020 Dec 13.

Institute of Medical Biometry and Statistics, Faculty of Medicine and Medical Center, University of Freiburg, Freiburg im Breisgau, Germany.

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December 2020

ideal: an R/Bioconductor package for interactive differential expression analysis.

BMC Bioinformatics 2020 Dec 9;21(1):565. Epub 2020 Dec 9.

Institute of Medical Biometry and Statistics, Faculty of Medicine and Medical Center, University of Freiburg, Stefan-Meier-Str. 26, 79104, Freiburg, Germany.

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December 2020

App-Controlled Treatment Monitoring and Support for Head and Neck Cancer Patients (APCOT): Protocol for a Prospective Randomized Controlled Trial.

JMIR Res Protoc 2020 Dec 9;9(12):e21693. Epub 2020 Dec 9.

Department of Radiation Oncology, Faculty of Medicine and University Medical Center Freiburg, University of Freiburg, Freiburg, Germany.

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December 2020

SPectroscOpic prediction of bRain Tumours (SPORT): study protocol of a prospective imaging trial.

BMC Med Imaging 2020 11 23;20(1):123. Epub 2020 Nov 23.

Department of Neurosurgery, Medical Centre, University of Freiburg, Breisacher Str. 64, 79106, Freiburg im Breisgau, Germany.

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November 2020

Synthetic observations from deep generative models and binary omics data with limited sample size.

Brief Bioinform 2020 Oct 2. Epub 2020 Oct 2.

Institute of Medical Biometry and Statistics, Faculty of Medicine and Medical Center, University of Freiburg, Germany.

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October 2020

[Asymmetric dimethylarginine (ADMA) in retinal vein occlusion-Results from the Gutenberg RVO study].

Ophthalmologe 2020 Sep 17. Epub 2020 Sep 17.

Augenklinik und Poliklinik, Universitätsmedizin Mainz, Langenbeckstr. 1, 55131, Mainz, Deutschland.

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September 2020

Annotation of Human Exome Gene Variants with Consensus Pathogenicity.

Genes (Basel) 2020 Sep 14;11(9). Epub 2020 Sep 14.

Institute of Medical Biometry and Statistics, Faculty of Medicine and Medical Center, University of Freiburg, 79104 Freiburg im Breisgau, Germany.

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September 2020

Psychological interventions to foster resilience in healthcare students.

Cochrane Database Syst Rev 2020 07 20;7:CD013684. Epub 2020 Jul 20.

Leibniz Institute for Resilience Research (LIR), Mainz, Germany.

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July 2020

Exploring generative deep learning for omics data using log-linear models.

Bioinformatics 2020 Dec;36(20):5045-5053

Institute of Medical Biometry and Statistics, Faculty of Medicine and Medical Center - University of Freiburg, 79104 Freiburg, Germany.

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December 2020

Psychological interventions to foster resilience in healthcare professionals.

Cochrane Database Syst Rev 2020 07 5;7:CD012527. Epub 2020 Jul 5.

Leibniz Institute for Resilience Research (LIR), Mainz, Germany.

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July 2020

Management and outcome of traumatic subdural hematoma in 47 infants and children from a single center.

Wien Klin Wochenschr 2020 Sep 24;132(17-18):499-505. Epub 2020 Apr 24.

Department of Orthopaedics and Trauma Surgery, Division of Trauma Surgery, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria.

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September 2020

State of the art in selection of variables and functional forms in multivariable analysis-outstanding issues.

Diagn Progn Res 2020 2;4. Epub 2020 Apr 2.

6Section for Clinical Biometrics, Center for Medical Statistics, Informatics and Intelligent Systems, Medical University of Vienna, Vienna, Austria.

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April 2020

Automatic variable selection for exposure-driven propensity score matching with unmeasured confounders.

Biom J 2020 05 23;62(3):868-884. Epub 2020 Mar 23.

Institute of Medical Biometry and Statistics, Faculty of Medicine and Medical Center - University of Freiburg, Freiburg, Germany.

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May 2020

Recovery of original individual person data (IPD) inferences from empirical IPD summaries only: Applications to distributed computing under disclosure constraints.

Stat Med 2020 04 14;39(8):1183-1198. Epub 2020 Jan 14.

Institute of Medical Biometry and Statistics, Faculty of Medicine, Medical Center University of Freiburg, Freiburg, Germany.

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April 2020

Delayed Intracranial Hemorrhage in Patients with Head Trauma and Antithrombotic Therapy.

J Clin Med 2019 Oct 25;8(11). Epub 2019 Oct 25.

Department of Orthopedics and Trauma-Surgery, Medical University of Vienna, 1090 Vienna, Austria.

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October 2019

A multivariable approach for risk markers from pooled molecular data with only partial overlap.

BMC Med Genet 2019 07 19;20(1):128. Epub 2019 Jul 19.

Institute for Medical Biometry and Statistics, Faculty of Medicine and Medical Center - University of Freiburg, Stefan-Meier-Straße 26, Freiburg, 79104, Germany.

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July 2019

pcaExplorer: an R/Bioconductor package for interacting with RNA-seq principal components.

BMC Bioinformatics 2019 Jun 13;20(1):331. Epub 2019 Jun 13.

Institute of Medical Biometry and Statistics, Faculty of Medicine and Medical Center - University of Freiburg, Stefan-Meier-Str. 26, Freiburg, 79104, Germany.

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June 2019

Meta-analyses identify differentially expressed micrornas in Parkinson's disease.

Ann Neurol 2019 06;85(6):835-851

Genetic and Molecular Epidemiology Group, Lübeck Interdisciplinary Platform for Genome Analytics, Institutes of Neurogenetics & Cardiogenetics, University of Lübeck, Lübeck, Germany.

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June 2019

A Queue-Poll Extension and DataSHIELD: Standardised, Monitored, Indirect and Secure Access to Sensitive Data.

Stud Health Technol Inform 2019 ;258:115-119

Institute of Medical Biometry and Statistics, Faculty of Medicine and Medical Center, University of Freiburg.

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August 2019

The buried knot technique for all inside graft link preparation leads to superior biomechanical graft link stability.

Sci Rep 2019 02 6;9(1):1488. Epub 2019 Feb 6.

Department of Orthopedics and Trauma Surgery, Division of Trauma Surgery, Medical University of Vienna, Vienna, Austria.

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February 2019

Promoter-proximal pausing mediated by the exon junction complex regulates splicing.

Nat Commun 2019 01 31;10(1):521. Epub 2019 Jan 31.

Laboratory of RNA Epigenetics, Institute of Molecular Biology (IMB), 55128, Mainz, Germany.

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January 2019

Feasibility and utility of a cognitive screening for risk stratification in hospitalized older patients.

Int J Geriatr Psychiatry 2019 04 18;34(4):588-593. Epub 2019 Jan 18.

Department of Psychiatry and Psychotherapy, University Medical Center Mainz, Mainz, Germany.

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April 2019

Investigation of intraocular pressure fluctuation as a risk factor of glaucoma progression.

Clin Ophthalmol 2019 18;13:9-16. Epub 2018 Dec 18.

Department of Ophthalmology, University Medical Center Mainz, Mainz, Germany,

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December 2018

Fatigue in survivors of malignant melanoma and its determinants: a register-based cohort study.

Support Care Cancer 2019 Aug 11;27(8):2809-2818. Epub 2018 Dec 11.

Department of Psychosomatic Medicine and Psychotherapy, University Medical Center of the Johannes Gutenberg-University Mainz, Untere Zahlbacher Str. 8, 55131, Mainz, Germany.

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August 2019

Uncontrolled Diabetes Mellitus Has No Major Influence on the Platelet Transcriptome.

Biomed Res Int 2018 1;2018:8989252. Epub 2018 Nov 1.

Institut für Experimentelle und Klinische Pharmakologie und Toxikologie, Albert-Ludwigs-Universität Freiburg, D-79104 Freiburg, Germany.

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March 2019

PanCareLIFE: The scientific basis for a European project to improve long-term care regarding fertility, ototoxicity and health-related quality of life after cancer occurring among children and adolescents.

Eur J Cancer 2018 11 29;103:227-237. Epub 2018 Sep 29.

German Childhood Cancer Registry (GCCR), Institute of Medical Biostatistics, Epidemiology and Informatics, University Medical Center, Mainz, Germany.

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November 2018

Power of the Wilcoxon-Mann-Whitney test for non-inferiority in the presence of death-censored observations.

Biom J 2019 09 19;61(5):1187-1200. Epub 2018 Sep 19.

Institute of Medical Biometry and Statistics, Medical Faculty and Medical Center - University Freiburg, Freiburg, Germany.

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September 2019

Modeling Activity Tracker Data Using Deep Boltzmann Machines.

Stud Health Technol Inform 2018 ;253:155-159

Institute of Medical Biometry and Statistics, Faculty of Medicine and Medical Center - University of Freiburg.

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November 2018

Mechanisms and modulators of cognitive training gain transfer in cognitively healthy aging: study protocol of the AgeGain study.

Trials 2018 Jun 27;19(1):337. Epub 2018 Jun 27.

Department of Psychiatry and Psychotherapy, University Medical Center Mainz, Untere Zahlbacher Straße 8, 55131, Mainz, Germany.

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June 2018

Determinants of illness-specific social support and its relation to distress in long-term melanoma survivors.

BMC Public Health 2018 04 17;18(1):511. Epub 2018 Apr 17.

Department of Psychosomatic Medicine and Psychotherapy, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany.

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April 2018

The immune contexture of hepatocellular carcinoma predicts clinical outcome.

Sci Rep 2018 03 29;8(1):5351. Epub 2018 Mar 29.

Institute of Translational Immunology and Research Centre for Immunotherapy, University Medical Centre of the Johannes Gutenberg University Mainz, Mainz, Germany.

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March 2018

Time-to-first-event versus recurrent-event analysis: points to consider for selecting a meaningful analysis strategy in clinical trials with composite endpoints.

Clin Res Cardiol 2018 May 16;107(5):437-443. Epub 2018 Feb 16.

Institute of Medical Biostatistics, Epidemiology and Informatics, University of Mainz, Mainz, Germany.

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May 2018

On the necessity and design of studies comparing statistical methods.

Biom J 2018 01 29;60(1):216-218. Epub 2017 Nov 29.

Institute for Medical Biometry and Statistics, Faculty of Medicine and Medical Center, University of Freiburg, Stefan-Meier-Str. 26, 79104, Freiburg, Germany.

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January 2018

Acromioclavicular joint dislocation treated with Bosworth screw and additional K-wiring: results after 7.8 years - still an adequate procedure?

BMC Musculoskelet Disord 2017 Aug 4;18(1):339. Epub 2017 Aug 4.

Department of Trauma Surgery, Medical University of Vienna, Waehringer Guertel 18-20, A-1090, Vienna, Austria.

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August 2017

A DAG-based comparison of interventional effect underestimation between composite endpoint and multi-state analysis in cardiovascular trials.

BMC Med Res Methodol 2017 Jul 4;17(1):92. Epub 2017 Jul 4.

Institute of Medical Biostatistics, Epidemiology and Informatics, University Medical Center Johannes Gutenberg-University Mainz, Obere Zahlbacher Str. 69, Mainz, 55131, Germany.

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July 2017

Partitioned learning of deep Boltzmann machines for SNP data.

Bioinformatics 2017 Oct;33(20):3173-3180

Institute of Medical Biostatistics, Epidemiology and Informatics (IMBEI), University Medical Center, 55131 Mainz, Germany.

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October 2017

Simulation of complex data structures for planning of studies with focus on biomarker comparison.

BMC Med Res Methodol 2017 Jun 13;17(1):90. Epub 2017 Jun 13.

Institute for Medical Biometry and Statistics, Faculty of Medicine and Medical Center - University of Freiburg, Stefan-Meier-Str. 26, Freiburg, 79104, Germany.

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June 2017

Retinal vessel metrics: normative data and their use in systemic hypertension: results from the Gutenberg Health Study.

J Hypertens 2017 08;35(8):1635-1645

aDepartment of Ophthalmology bDepartment of Preventive Cardiology and Preventive Medicine, Center for Cardiology I cInstitute of Medical Biostatistics, Epidemiology and Informatics, Division of Biostatistics and Bioinformatics dDepartment of Psychosomatic Medicine and Psychotherapy eInstitute of Clinical Chemistry and Laboratory Medicine fCenter for Thrombosis and Hemostasis, University Medical Center gDZHK (German Center for Cardiovascular Research), Partner Site Rhine Main, Langenbeckstr. 1, Mainz, Germany hDepartment of Ophthalmology, University Hospital Bern, Bern, Switzerland iDardenne Eye Hospital, Bonn-Bad Godesberg, Germany.

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August 2017

Comparison of HapMap and 1000 Genomes Reference Panels in a Large-Scale Genome-Wide Association Study.

PLoS One 2017 20;12(1):e0167742. Epub 2017 Jan 20.

Department of Epidemiology, Erasmus MC, Rotterdam, the Netherlands.

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August 2017

Feasibility of sample size calculation for RNA-seq studies.

Brief Bioinform 2018 07;19(4):713-720

Institute of Medical Biostatistics, Epidemiology and Informatics, University Medical Center Johannes Gutenberg University Mainz, Langenbeckstr, Mainz, Germany.

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July 2018

Prospective validation of a blood-based 9-miRNA profile for early detection of breast cancer in a cohort of women examined by clinical mammography.

Mol Oncol 2016 12 1;10(10):1621-1626. Epub 2016 Nov 1.

Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark; Department of Oncology, Odense University Hospital, Odense, Denmark. Electronic address:

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December 2016

Myopia and Cognitive Performance: Results From the Gutenberg Health Study.

Invest Ophthalmol Vis Sci 2016 Oct;57(13):5230-5236

Medical Psychology and Medical Sociology, University Medical Center Mainz, Germany 6Medical Psychology and Medical Sociology, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

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October 2016

Integrating multiple molecular sources into a clinical risk prediction signature by extracting complementary information.

BMC Bioinformatics 2016 Aug 30;17(1):327. Epub 2016 Aug 30.

Institute of Medical Biostatistics, Epidemiology and Informatics, University Medical Center Johannes Gutenberg University Mainz, Obere Zahlbacher Str. 69, Mainz, 55131, Germany.

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August 2016

Displaced juvenile Tillaux fractures : Surgical treatment and outcome.

Wien Klin Wochenschr 2017 Mar 17;129(5-6):169-175. Epub 2016 Aug 17.

Department of Trauma Surgery, Medical University Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria.

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March 2017

PREVALENCE AND ASSOCIATIONS OF MYELINATED RETINAL NERVE FIBERS: Results From the Population-Based Gutenberg Health Study.

Retina 2016 Dec;36(12):2364-2370

*Department of Ophthalmology, University Medical Center Mainz, Mainz, Germany; †NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, United Kingdom; ‡Department of Ophthalmology, Philipps University of Marburg, Marburg, Germany; §Center for Thrombosis and Hemostasis (CTH), University Medical Center Mainz, Mainz, Germany; ¶Department of Biostatistics, University Medical Center Mainz, Mainz, Germany; and **Dardenne Eye Hospital, Bonn-Bad Godesberg, Germany.

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December 2016

Noise Annoyance Is Associated with Depression and Anxiety in the General Population- The Contribution of Aircraft Noise.

PLoS One 2016 19;11(5):e0155357. Epub 2016 May 19.

Medical Clinic for Cardiology, Angiology and Intensive Care Medicine, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.

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July 2017

Identifying Prognostic SNPs in Clinical Cohorts: Complementing Univariate Analyses by Resampling and Multivariable Modeling.

PLoS One 2016 9;11(5):e0155226. Epub 2016 May 9.

Institute of Medical Biostatistics, Epidemiology and Informatics, University Medical Center Johannes Gutenberg University Mainz, Mainz, Germany.

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July 2017

Antiphospholipid antibodies in a large population-based cohort: genome-wide associations and effects on monocyte gene expression.

Thromb Haemost 2016 07 21;116(1):115-23. Epub 2016 Apr 21.

Dr. Karl J. Lackner, Institute of Clinical Chemistry and Laboratory Medicine, University Medical Center Mainz, Langenbeckstrasse 1, D-55131 Mainz, Germany, Tel.: +49 6131 177190, E-mail:

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July 2016

Home treatment of patients with low-risk pulmonary embolism with the oral factor Xa inhibitor rivaroxaban. Rationale and design of the HoT-PE Trial.

Thromb Haemost 2016 07 24;116(1):191-7. Epub 2016 Mar 24.

Stavros V. Konstantinides, MD, FESC, Center for Thrombosis and Hemostasis, University Medical Center Mainz, Langenbeckstrasse 1, Building 403, 55131 Mainz, Germany, Tel.: +49 6131 17 8382, Fax: +49 6131 17 3456, E-mail:

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July 2016

Bioresorbable Coronary Scaffold Thrombosis: Multicenter Comprehensive Analysis of Clinical Presentation, Mechanisms, and Predictors.

J Am Coll Cardiol 2016 Mar;67(8):921-931

Zentrum für Kardiologie, University Hospital Mainz, Mainz, Germany, and German Center for Cardiac and Vascular Research (DZHK), Standort Rhein-Main, Mainz, Germany. Electronic address:

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March 2016

Gene expression patterns underlying parasite-induced alterations in host behaviour and life history.

Mol Ecol 2016 01 19;25(2):648-60. Epub 2016 Jan 19.

Evolutionary Biology, Johannes Gutenberg University Mainz, Johannes-von-Müller-Weg 6, 55128, Mainz, Germany.

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January 2016

A meta-analysis of 120 246 individuals identifies 18 new loci for fibrinogen concentration.

Authors:
Paul S de Vries Daniel I Chasman Maria Sabater-Lleal Ming-Huei Chen Jennifer E Huffman Maristella Steri Weihong Tang Alexander Teumer Riccardo E Marioni Vera Grossmann Jouke J Hottenga Stella Trompet Martina Müller-Nurasyid Jing Hua Zhao Jennifer A Brody Marcus E Kleber Xiuqing Guo Jie Jin Wang Paul L Auer John R Attia Lisa R Yanek Tarunveer S Ahluwalia Jari Lahti Cristina Venturini Toshiko Tanaka Lawrence F Bielak Peter K Joshi Ares Rocanin-Arjo Ivana Kolcic Pau Navarro Lynda M Rose Christopher Oldmeadow Helene Riess Johanna Mazur Saonli Basu Anuj Goel Qiong Yang Mohsen Ghanbari Gonneke Willemsen Ann Rumley Edoardo Fiorillo Anton J M de Craen Anne Grotevendt Robert Scott Kent D Taylor Graciela E Delgado Jie Yao Annette Kifley Charles Kooperberg Rehan Qayyum Lorna M Lopez Tina L Berentzen Katri Räikkönen Massimo Mangino Stefania Bandinelli Patricia A Peyser Sarah Wild David-Alexandre Trégouët Alan F Wright Jonathan Marten Tatijana Zemunik Alanna C Morrison Bengt Sennblad Geoffrey Tofler Moniek P M de Maat Eco J C de Geus Gordon D Lowe Magdalena Zoledziewska Naveed Sattar Harald Binder Uwe Völker Melanie Waldenberger Kay-Tee Khaw Barbara Mcknight Jie Huang Nancy S Jenny Elizabeth G Holliday Lihong Qi Mark G Mcevoy Diane M Becker John M Starr Antti-Pekka Sarin Pirro G Hysi Dena G Hernandez Min A Jhun Harry Campbell Anders Hamsten Fernando Rivadeneira Wendy L Mcardle P Eline Slagboom Tanja Zeller Wolfgang Koenig Bruce M Psaty Talin Haritunians Jingmin Liu Aarno Palotie André G Uitterlinden David J Stott Albert Hofman Oscar H Franco Ozren Polasek Igor Rudan Pierre-Emmanuel Morange James F Wilson Sharon L R Kardia Luigi Ferrucci Tim D Spector Johan G Eriksson Torben Hansen Ian J Deary Lewis C Becker Rodney J Scott Paul Mitchell Winfried März Nick J Wareham Annette Peters Andreas Greinacher Philipp S Wild J Wouter Jukema Dorret I Boomsma Caroline Hayward Francesco Cucca Russell Tracy Hugh Watkins Alex P Reiner Aaron R Folsom Paul M Ridker Christopher J O'Donnell Nicholas L Smith David P Strachan Abbas Dehghan

Hum Mol Genet 2016 Jan 10;25(2):358-70. Epub 2015 Nov 10.

Department of Epidemiology,

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January 2016

Treatment of proximal humerus fractures in children and young adolescents.

Wien Klin Wochenschr 2016 Feb 6;128(3-4):120-4. Epub 2015 Nov 6.

Department of Trauma Surgery, Medical University Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria.

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February 2016

Stagewise pseudo-value regression for time-varying effects on the cumulative incidence.

Stat Med 2016 Mar 28;35(7):1144-58. Epub 2015 Oct 28.

Institute of Medical Biostatistics, Epidemiology and Informatics, University Medical Center, Johannes Gutenberg University Mainz, 55101, Mainz, Germany.

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March 2016

Genome-wide significant association with seven novel multiple sclerosis risk loci.

J Med Genet 2015 Dec 16;52(12):848-55. Epub 2015 Oct 16.

Platform for Genome Analytics, Institutes of Neurogenetics & Integrative and Experimental Genomics, University of Lübeck, Lübeck, Germany Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Berlin, Germany Department of Medicine, School of Public Health, Imperial College London, London, UK.

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December 2015

Disease Burden of Rotavirus Gastroenteritis in Children Residing in Germany: A Retrospective, Hospital-based Surveillance.

Pediatr Infect Dis J 2016 Jan;35(1):97-103

From the *Pediatric Department and †Institute of Medical Biostatistics, Epidemiology and Informatics (IMBEI), University Medical Center of the Johannes Gutenberg University, Mainz, Germany; ‡Johannes Gutenberg University Mainz, Faculty of Economics, Mainz, Germany; §Klinikum der Landeshauptstadt Wiesbaden HSK, Dr Horst Schmidt Kliniken, Wiesbaden, Germany; ¶Pediatric Infectious Diseases, Department of Pediatrics, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany; ‖Pediatric Department, University Hospital Carl Gustav Carus, Dresden, Germany; **Sanofi Pasteur MSD GmbH, Leimen, Germany; and ††Institute for Community Medicine, University Medicine of the Ernst-Moritz-Arndt University, Greifswald, Germany.

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January 2016

A weighting approach for judging the effect of patient strata on high-dimensional risk prediction signatures.

BMC Bioinformatics 2015 Sep 15;16:294. Epub 2015 Sep 15.

Institute of Medical Biostatistics, Epidemiology and Informatics (IMBEI), University Medical Center Mainz, Johannes Gutenberg-University Mainz, Obere Zahlbacher Strasse 69, Mainz, Germany.

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September 2015

Pitfalls of hypothesis tests and model selection on bootstrap samples: Causes and consequences in biometrical applications.

Biom J 2016 May 15;58(3):447-73. Epub 2015 Sep 15.

Department of Medical Informatics, Biometry and Epidemiology, University of Munich, Marchioninistr. 15, 81377 Munich, Germany.

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May 2016

Psychosocial Care Needs of Melanoma Survivors: Are They Being Met?

PLoS One 2015 21;10(8):e0132754. Epub 2015 Aug 21.

Department of Psychosomatic Medicine and Psychotherapy, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany.

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May 2016

Large platelets but not putative endothelial progenitor cells are associated with low strut coverage after drug-eluting stent implantation.

Int J Cardiol 2015 Nov 29;199:358-65. Epub 2015 Jul 29.

Universitäts-Herzzentrum Freiburg • Bad Krozingen, Klinik für Kardiologie und Angiologie II, Südring 15, D-79189 Bad Krozingen, Germany.

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November 2015

Prevalence, Phenotype, and Psychosocial Well-Being in Euthyroid/Hypothyroid Thyroid-Associated Orbitopathy.

Thyroid 2015 Aug 4;25(8):942-8. Epub 2015 Jun 4.

4 Department of Medicine I, Johannes Gutenberg University Medical Center , Mainz, Germany .

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August 2015