Harald Binder

Harald Binder

UNVERIFIED PROFILE

Are you Harald Binder?   Register this Author

Register author
Harald Binder

Harald Binder

Publications by authors named "Harald Binder"

Are you Harald Binder?   Register this Author

100Publications

2673Reads

6Profile Views

Genetic variation of cisplatin-induced ototoxicity in non-cranial-irradiated pediatric patients using a candidate gene approach: The International PanCareLIFE Study.

Authors:
Eva Clemens Linda Broer Thorsten Langer André G Uitterlinden Andrica C H de Vries Martine van Grotel Saskia F M Pluijm Harald Binder Julianne Byrne Eline van Dulmen-den Broeder Marco Crocco Desiree Grabow Peter Kaatsch Melanie Kaiser Line Kenborg Jeanette F Winther Catherine Rechnitzer Henrik Hasle Tomas Kepak Anne-Lotte F van der Kooi Leontien C Kremer Jarmila Kruseova Claudia E Kuehni Heleen van der Pal Ross Parfitt Dirk Deuster Peter Matulat Claudia Spix Amelie Tillmanns Wim J E Tissing Lara Maier Antoinette Am Zehnhoff-Dinnesen Oliver Zolk Marry M van den Heuvel-Eibrink

Pharmacogenomics J 2019 Oct 31. Epub 2019 Oct 31.

Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1038/s41397-019-0113-1DOI Listing
October 2019

Delayed Intracranial Hemorrhage in Patients with Head Trauma and Antithrombotic Therapy.

Authors:
Anna Antoni Elisabeth Schwendenwein Harald Binder Martin Schauperl Philip Datler Stefan Hajdu

J Clin Med 2019 Oct 25;8(11). Epub 2019 Oct 25.

Department of Orthopedics and Trauma-Surgery, Medical University of Vienna, 1090 Vienna, Austria.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.3390/jcm8111780DOI Listing
October 2019

Power of the Wilcoxon-Mann-Whitney test for non-inferiority in the presence of death-censored observations.

Authors:
Irene Schmidtmann Stavros Konstantinides Harald Binder

Biom J 2019 Sep 19;61(5):1187-1200. Epub 2018 Sep 19.

Institute of Medical Biometry and Statistics, Medical Faculty and Medical Center - University Freiburg, Freiburg, Germany.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1002/bimj.201700296DOI Listing
September 2019

Deconstructing and Reconstructing Resilience: A Dynamic Network Approach.

Authors:
Raffael Kalisch Angélique O J Cramer Harald Binder Jessica Fritz IJsbrand Leertouwer Gabriela Lunansky Benjamin Meyer Jens Timmer Ilya M Veer Anne-Laura van Harmelen

Perspect Psychol Sci 2019 09 31;14(5):765-777. Epub 2019 Jul 31.

5 Department of Psychiatry, University of Cambridge.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1177/1745691619855637DOI Listing
September 2019

Comparison of Different Hypotheses Regarding the Spread of Alzheimer's Disease Using Markov Random Fields and Multimodal Imaging.

Authors:
Martin Dyrba Michel J Grothe Abdolreza Mohammadi Harald Binder Thomas Kirste Stefan J Teipel

J Alzheimers Dis 2018 ;65(3):731-746

German Center for Neurodegenerative Diseases (DZNE), Site Rostock/Greifswald, Rostock, Germany.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.3233/JAD-161197DOI Listing
August 2019

Fatigue in survivors of malignant melanoma and its determinants: a register-based cohort study.

Authors:
Ana Nanette Tibubos Mareike Ernst Elmar Brähler Sabine Fischbeck Andreas Hinz Maria Blettner Sylke R Zeissig Veronika Weyer Barbara H Imruck Harald Binder Manfred E Beutel

Support Care Cancer 2019 Aug 11;27(8):2809-2818. Epub 2018 Dec 11.

Department of Psychosomatic Medicine and Psychotherapy, University Medical Center of the Johannes Gutenberg-University Mainz, Untere Zahlbacher Str. 8, 55131, Mainz, Germany.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1007/s00520-018-4587-1DOI Listing
August 2019

A Queue-Poll Extension and DataSHIELD: Standardised, Monitored, Indirect and Secure Access to Sensitive Data.

Authors:
Julian Gruendner Hans-Ulrich Prokosch Sebastian Schindler Stefan Lenz Harald Binder

Stud Health Technol Inform 2019 ;258:115-119

Institute of Medical Biometry and Statistics, Faculty of Medicine and Medical Center, University of Freiburg.

View Article

Download full-text PDF

 Source
August 2019

Hypertension and multiple cardiovascular risk factors increase the risk for retinal vein occlusions: results from the Gutenberg Retinal Vein Occlusion Study.

Authors:
Katharina A Ponto Inge Scharrer Harald Binder Christina Korb Ann K Rosner Till O Ehlers Nikola Rieser Nadja C Grübel Heidi Rossmann Philipp S Wild Nicolas Feltgen Norbert Pfeiffer Alireza Mirshahi

J Hypertens 2019 Jul;37(7):1372-1383

Department of Ophthalmology.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1097/HJH.0000000000002057DOI Listing
July 2019

A multivariable approach for risk markers from pooled molecular data with only partial overlap.

Authors:
Anne-Sophie Stelzer Livia Maccioni Aslihan Gerhold-Ay Karin E Smedby Martin Schumacher Alexandra Nieters Harald Binder

BMC Med Genet 2019 07 19;20(1):128. Epub 2019 Jul 19.

Institute for Medical Biometry and Statistics, Faculty of Medicine and Medical Center - University of Freiburg, Stefan-Meier-Straße 26, Freiburg, 79104, Germany.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1186/s12881-019-0849-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6642584PMC
July 2019

Meta-analyses identify differentially expressed micrornas in Parkinson's disease.

Authors:
Jessica Schulz Petros Takousis Inken Wohlers Ivie O G Itua Valerija Dobricic Gerta Rücker Harald Binder Lefkos Middleton John P A Ioannidis Robert Perneczky Lars Bertram Christina M Lill

Ann Neurol 2019 Jun;85(6):835-851

Genetic and Molecular Epidemiology Group, Lübeck Interdisciplinary Platform for Genome Analytics, Institutes of Neurogenetics & Cardiogenetics, University of Lübeck, Lübeck, Germany.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1002/ana.25490DOI Listing
June 2019

pcaExplorer: an R/Bioconductor package for interacting with RNA-seq principal components.

Authors:
Federico Marini Harald Binder

BMC Bioinformatics 2019 Jun 13;20(1):331. Epub 2019 Jun 13.

Institute of Medical Biometry and Statistics, Faculty of Medicine and Medical Center - University of Freiburg, Stefan-Meier-Str. 26, Freiburg, 79104, Germany.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1186/s12859-019-2879-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6567655PMC
June 2019

Feasibility and utility of a cognitive screening for risk stratification in hospitalized older patients.

Authors:
Katharina Geschke Veronika Weyer-Elberich Anne-Kristin Mueller Harald Binder Andreas Fellgiebel

Int J Geriatr Psychiatry 2019 04 18;34(4):588-593. Epub 2019 Jan 18.

Department of Psychiatry and Psychotherapy, University Medical Center Mainz, Mainz, Germany.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1002/gps.5056DOI Listing
April 2019

BAL Cell Gene Expression Is Indicative of Outcome and Airway Basal Cell Involvement in Idiopathic Pulmonary Fibrosis.

Authors:
Antje Prasse Harald Binder Jonas C Schupp Gian Kayser Elena Bargagli Benedikt Jaeger Moritz Hess Susanne Rittinghausen Louis Vuga Heather Lynn Shelia Violette Birgit Jung Karsten Quast Bart Vanaudenaerde Yan Xu Jens M Hohlfeld Norbert Krug Jose D Herazo-Maya Paola Rottoli Wim A Wuyts Naftali Kaminski

Am J Respir Crit Care Med 2019 Mar;199(5):622-630

9 Section of Pulmonary, Critical Care and Sleep Medicine, Yale School of Medicine, New Haven, Connecticut.

View Article

Download full-text PDF

 Source
https://www.atsjournals.org/doi/10.1164/rccm.201712-2551OC
Publisher Site
http://dx.doi.org/10.1164/rccm.201712-2551OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396865PMC
March 2019

Uncontrolled Diabetes Mellitus Has No Major Influence on the Platelet Transcriptome.

Authors:
Thomas G Nührenberg Marco Cederqvist Federico Marini Christian Stratz Björn A Grüning Dietmar Trenk Harald Binder Ralf Gilsbach Franz-Josef Neumann Lutz Hein

Biomed Res Int 2018 1;2018:8989252. Epub 2018 Nov 1.

Institut für Experimentelle und Klinische Pharmakologie und Toxikologie, Albert-Ludwigs-Universität Freiburg, D-79104 Freiburg, Germany.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1155/2018/8989252DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6241365PMC
March 2019

Genetic Determinants of Ototoxicity During and After Childhood Cancer Treatment: Protocol for the PanCareLIFE Study.

Authors:
Eva Clemens Annelot Jm Meijer Linda Broer Thorsten Langer Anne-Lotte Lf van der Kooi André G Uitterlinden Andrica de Vries Claudia E Kuehni Maria L Garrè Tomas Kepak Jarmila Kruseova Jeanette F Winther Leontien C Kremer Eline van Dulmen-den Broeder Wim Je Tissing Catherine Rechnitzer Line Kenborg Henrik Hasle Desiree Grabow Ross Parfitt Harald Binder Bruce C Carleton Julianne Byrne Peter Kaatsch Antoinette Am Zehnhoff-Dinnesen Oliver Zolk Marry M van den Heuvel-Eibrink

JMIR Res Protoc 2019 Mar 19;8(3):e11868. Epub 2019 Mar 19.

Princess Maxima Center for Pediatric Oncology, Utrecht, Netherlands.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.2196/11868DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444213PMC
March 2019

The buried knot technique for all inside graft link preparation leads to superior biomechanical graft link stability.

Authors:
Thomas M Tiefenboeck Lena Hirtler Markus Winnisch Harald Binder Thomas Koch Micha Komjati Marcus Hofbauer Roman C Ostermann

Sci Rep 2019 Feb 6;9(1):1488. Epub 2019 Feb 6.

Department of Orthopedics and Trauma Surgery, Division of Trauma Surgery, Medical University of Vienna, Vienna, Austria.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1038/s41598-018-38150-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365500PMC
February 2019

Promoter-proximal pausing mediated by the exon junction complex regulates splicing.

Authors:
Junaid Akhtar Nastasja Kreim Federico Marini Giriram Mohana Daniel Brüne Harald Binder Jean-Yves Roignant

Nat Commun 2019 01 31;10(1):521. Epub 2019 Jan 31.

Laboratory of RNA Epigenetics, Institute of Molecular Biology (IMB), 55128, Mainz, Germany.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1038/s41467-019-08381-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355915PMC
January 2019

Transcriptome 3'end organization by PCF11 links alternative polyadenylation to formation and neuronal differentiation of neuroblastoma.

Authors:
Anton Ogorodnikov Michal Levin Surendra Tattikota Sergey Tokalov Mainul Hoque Denise Scherzinger Federico Marini Ansgar Poetsch Harald Binder Stephan Macher-Göppinger Hans Christian Probst Bin Tian Michael Schaefer Karl J Lackner Frank Westermann Sven Danckwardt

Nat Commun 2018 12 14;9(1):5331. Epub 2018 Dec 14.

Posttranscriptional Gene Regulation, Cancer Research and Experimental Haemostasis, University Medical Centre Mainz, Mainz, 55131, Germany.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1038/s41467-018-07580-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294251PMC
December 2018

Investigation of intraocular pressure fluctuation as a risk factor of glaucoma progression.

Authors:
Juliane Matlach Sandra Bender Jochem König Harald Binder Norbert Pfeiffer Esther M Hoffmann

Clin Ophthalmol 2019 18;13:9-16. Epub 2018 Dec 18.

Department of Ophthalmology, University Medical Center Mainz, Mainz, Germany,

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.2147/OPTH.S186526DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6302802PMC
December 2018

Association of ocular, cardiovascular, morphometric and lifestyle parameters with retinal nerve fibre layer thickness.

Authors:
Julia Lamparter Irene Schmidtmann Alexander K Schuster Angeliki Siouli Joanna Wasielica-Poslednik Alireza Mirshahi René Höhn Josef Unterrainer Philipp S Wild Harald Binder Karl Lackner Manfred E Beutel Thomas Münzel Norbert Pfeiffer Esther M Hoffmann

PLoS One 2018 22;13(5):e0197682. Epub 2018 May 22.

Department of Ophthalmology, University Medical Center Mainz, Mainz, Germany.

View Article

Download full-text PDF

 Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0197682PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5963756PMC
November 2018

Modeling Activity Tracker Data Using Deep Boltzmann Machines.

Authors:
Martin Treppner Stefan Lenz Harald Binder Daniela Zöller

Stud Health Technol Inform 2018 ;253:155-159

Institute of Medical Biometry and Statistics, Faculty of Medicine and Medical Center - University of Freiburg.

View Article

Download full-text PDF

 Source
November 2018

PanCareLIFE: The scientific basis for a European project to improve long-term care regarding fertility, ototoxicity and health-related quality of life after cancer occurring among children and adolescents.

Authors:
Julianne Byrne Desiree Grabow Helen Campbell Kylie O'Brien Stefan Bielack Antoinette Am Zehnhoff-Dinnesen Gabriele Calaminus Leontien Kremer Thorsten Langer Marry M van den Heuvel-Eibrink Eline van Dulmen-den Broeder Katja Baust Andrea Bautz Jörn D Beck Claire Berger Harald Binder Anja Borgmann-Staudt Linda Broer Holger Cario Leonie Casagranda Eva Clemens Dirk Deuster Andrica de Vries Uta Dirksen Jeanette Falck Winther Sophie Fosså Anna Font-Gonzalez Victoria Grandage Riccardo Haupt Stefanie Hecker-Nolting Lars Hjorth Melanie Kaiser Line Kenborg Tomas Kepak Kateřina Kepáková Lisbeth E Knudsen Maryna Krawczuk-Rybak Jarmila Kruseova Claudia E Kuehni Marina Kunstreich Rahel Kuonen Herwig Lackner Alison Leiper Erik A H Loeffen Ales Luks Dalit Modan-Moses Renee Mulder Ross Parfitt Norbert W Paul Andreas Ranft Ellen Ruud Ralph Schilling Claudia Spix Joanna Stefanowicz Gabriele Strauβ Andre G Uitterlinden Marleen van den Berg Anne-Lotte van der Kooi Marloes van Dijk Flora van Leeuwen Oliver Zolk Daniela Zöller Peter Kaatsch

Eur J Cancer 2018 11 29;103:227-237. Epub 2018 Sep 29.

German Childhood Cancer Registry (GCCR), Institute of Medical Biostatistics, Epidemiology and Informatics, University Medical Center, Mainz, Germany.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.ejca.2018.08.007DOI Listing
November 2018

Norovirus Gastroenteritis among Hospitalized Patients, Germany, 2007-2012.

Authors:
Frank Kowalzik Harald Binder Daniela Zöller Margarita Riera-Montes Ralf Clemens Thomas Verstraeten Fred Zepp

Emerg Infect Dis 2018 11;24(11):2021-2028

View Article

Download full-text PDF

 Source
http://wwwnc.cdc.gov/eid/article/24/11/17-0820_article.htm
Publisher Site
http://dx.doi.org/10.3201/eid2411.170820DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6199990PMC
November 2018

Intake of Vitamin K Antagonists and Worsening of Cardiac and Vascular Disease: Results From the Population-Based Gutenberg Health Study.

Authors:
Lisa Eggebrecht Jürgen H Prochaska Andreas Schulz Natalie Arnold Claus Jünger Sebastian Göbel Dagmar Laubert-Reh Harald Binder Manfred E Beutel Nobert Pfeiffer Stefan Blankenberg Karl J Lackner Henri M Spronk Hugo Ten Cate Thomas Münzel Philipp S Wild

J Am Heart Assoc 2018 09;7(17):e008650

1 Preventive Cardiology and Preventive Medicine Center for Cardiology University Medical Center Mainz Mainz Germany.

View Article

Download full-text PDF

 Source
https://www.ahajournals.org/doi/10.1161/JAHA.118.008650
Publisher Site
http://dx.doi.org/10.1161/JAHA.118.008650DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6201416PMC
September 2018

Feasibility of sample size calculation for RNA-seq studies.

Authors:
Alicia Poplawski Harald Binder

Brief Bioinform 2018 07;19(4):713-720

Institute of Medical Biostatistics, Epidemiology and Informatics, University Medical Center Johannes Gutenberg University Mainz, Langenbeckstr, Mainz, Germany.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1093/bib/bbw144DOI Listing
July 2018

MIRACUM: Medical Informatics in Research and Care in University Medicine.

Authors:
Hans-Ulrich Prokosch Till Acker Johannes Bernarding Harald Binder Martin Boeker Melanie Boerries Philipp Daumke Thomas Ganslandt Jürgen Hesser Gunther Höning Michael Neumaier Kurt Marquardt Harald Renz Hermann-Josef Rothkötter Carmen Schade-Brittinger Paul Schmücker Jürgen Schüttler Martin Sedlmayr Hubert Serve Keywan Sohrabi Holger Storf

Methods Inf Med 2018 07 17;57(S 01):e82-e91. Epub 2018 Jul 17.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.3414/ME17-02-0025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6178200PMC
July 2018

Mechanisms and modulators of cognitive training gain transfer in cognitively healthy aging: study protocol of the AgeGain study.

Authors:
Dominik Wolf Oliver Tüscher Stefan Teipel Andreas Mierau Heiko Strüder Alexander Drzezga Bernhard Baier Harald Binder Andreas Fellgiebel

Trials 2018 Jun 27;19(1):337. Epub 2018 Jun 27.

Department of Psychiatry and Psychotherapy, University Medical Center Mainz, Untere Zahlbacher Straße 8, 55131, Mainz, Germany.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1186/s13063-018-2688-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6020358PMC
June 2018

Time-to-first-event versus recurrent-event analysis: points to consider for selecting a meaningful analysis strategy in clinical trials with composite endpoints.

Authors:
Geraldine Rauch Meinhard Kieser Harald Binder Antoni Bayes-Genis Antje Jahn-Eimermacher

Clin Res Cardiol 2018 May 16;107(5):437-443. Epub 2018 Feb 16.

Institute of Medical Biostatistics, Epidemiology and Informatics, University of Mainz, Mainz, Germany.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1007/s00392-018-1205-7DOI Listing
May 2018

Determinants of illness-specific social support and its relation to distress in long-term melanoma survivors.

Authors:
Sabine Fischbeck Veronika Weyer-Elberich Sylke R Zeissig Barbara H Imruck Maria Blettner Harald Binder Manfred E Beutel

BMC Public Health 2018 04 17;18(1):511. Epub 2018 Apr 17.

Department of Psychosomatic Medicine and Psychotherapy, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1186/s12889-018-5401-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5904995PMC
April 2018

The immune contexture of hepatocellular carcinoma predicts clinical outcome.

Authors:
Friedrich Foerster Moritz Hess Aslihan Gerhold-Ay Jens Uwe Marquardt Diana Becker Peter Robert Galle Detlef Schuppan Harald Binder Ernesto Bockamp

Sci Rep 2018 03 29;8(1):5351. Epub 2018 Mar 29.

Institute of Translational Immunology and Research Centre for Immunotherapy, University Medical Centre of the Johannes Gutenberg University Mainz, Mainz, Germany.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1038/s41598-018-21937-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5876395PMC
March 2018

On the necessity and design of studies comparing statistical methods.

Authors:
Anne-Laure Boulesteix Harald Binder Michal Abrahamowicz Willi Sauerbrei

Biom J 2018 01 29;60(1):216-218. Epub 2017 Nov 29.

Institute for Medical Biometry and Statistics, Faculty of Medicine and Medical Center, University of Freiburg, Stefan-Meier-Str. 26, 79104, Freiburg, Germany.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1002/bimj.201700129DOI Listing
January 2018

Dabigatran after Short Heparin Anticoagulation for Acute Intermediate-Risk Pulmonary Embolism: Rationale and Design of the Single-Arm PEITHO-2 Study.

Authors:
Frederikus A Klok Walter Ageno Stefano Barco Harald Binder Benjamin Brenner Daniel Duerschmied Klaus Empen Pompilio Faggiano Joachim H Ficker Nazzareno Galiè Alexandre Ghuysen Matthias Held Nadine Heydenreich Menno V Huisman David Jiménez Matija Kozak Irene M Lang Mareike Lankeit Thomas Münzel Antoniu Petris Piotr Pruszczyk Kurt Quitzau Sebastian Schellong Kai-Helge Schmidt Branislav S Stefanovic Franck Verschuren Anamaria Wolf-Puetz Guy Meyer Stavros V Konstantinides

Thromb Haemost 2017 12 6;117(12):2425-2434. Epub 2017 Dec 6.

Center for Thrombosis and Hemostasis, University Medical Center Mainz, Mainz, Germany.

View Article

Download full-text PDF

 Source
http://www.thieme-connect.de/DOI/DOI?10.1160/TH17-06-0434
Publisher Site
http://dx.doi.org/10.1160/TH17-06-0434DOI Listing
December 2017

Partitioned learning of deep Boltzmann machines for SNP data.

Authors:
Moritz Hess Stefan Lenz Tamara J Blätte Lars Bullinger Harald Binder

Bioinformatics 2017 Oct;33(20):3173-3180

Institute of Medical Biostatistics, Epidemiology and Informatics (IMBEI), University Medical Center, 55131 Mainz, Germany.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1093/bioinformatics/btx408DOI Listing
October 2017

Comparison of HapMap and 1000 Genomes Reference Panels in a Large-Scale Genome-Wide Association Study.

Authors:
Paul S de Vries Maria Sabater-Lleal Daniel I Chasman Stella Trompet Tarunveer S Ahluwalia Alexander Teumer Marcus E Kleber Ming-Huei Chen Jie Jin Wang John R Attia Riccardo E Marioni Maristella Steri Lu-Chen Weng Rene Pool Vera Grossmann Jennifer A Brody Cristina Venturini Toshiko Tanaka Lynda M Rose Christopher Oldmeadow Johanna Mazur Saonli Basu Mattias Frånberg Qiong Yang Symen Ligthart Jouke J Hottenga Ann Rumley Antonella Mulas Anton J M de Craen Anne Grotevendt Kent D Taylor Graciela E Delgado Annette Kifley Lorna M Lopez Tina L Berentzen Massimo Mangino Stefania Bandinelli Alanna C Morrison Anders Hamsten Geoffrey Tofler Moniek P M de Maat Harmen H M Draisma Gordon D Lowe Magdalena Zoledziewska Naveed Sattar Karl J Lackner Uwe Völker Barbara McKnight Jie Huang Elizabeth G Holliday Mark A McEvoy John M Starr Pirro G Hysi Dena G Hernandez Weihua Guan Fernando Rivadeneira Wendy L McArdle P Eline Slagboom Tanja Zeller Bruce M Psaty André G Uitterlinden Eco J C de Geus David J Stott Harald Binder Albert Hofman Oscar H Franco Jerome I Rotter Luigi Ferrucci Tim D Spector Ian J Deary Winfried März Andreas Greinacher Philipp S Wild Francesco Cucca Dorret I Boomsma Hugh Watkins Weihong Tang Paul M Ridker Jan W Jukema Rodney J Scott Paul Mitchell Torben Hansen Christopher J O'Donnell Nicholas L Smith David P Strachan Abbas Dehghan

PLoS One 2017 20;12(1):e0167742. Epub 2017 Jan 20.

Department of Epidemiology, Erasmus MC, Rotterdam, the Netherlands.

View Article

Download full-text PDF

 Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0167742PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5249120PMC
August 2017

Retinal vessel metrics: normative data and their use in systemic hypertension: results from the Gutenberg Health Study.

Authors:
Katharina A Ponto David J Werner Linn Wiedemer Dagmar Laubert-Reh Alexander K Schuster Stefan Nickels René Höhn Andreas Schulz Harald Binder Manfred Beutel Karl J Lackner Philipp S Wild Norbert Pfeiffer Alireza Mirshahi

J Hypertens 2017 08;35(8):1635-1645

aDepartment of Ophthalmology bDepartment of Preventive Cardiology and Preventive Medicine, Center for Cardiology I cInstitute of Medical Biostatistics, Epidemiology and Informatics, Division of Biostatistics and Bioinformatics dDepartment of Psychosomatic Medicine and Psychotherapy eInstitute of Clinical Chemistry and Laboratory Medicine fCenter for Thrombosis and Hemostasis, University Medical Center gDZHK (German Center for Cardiovascular Research), Partner Site Rhine Main, Langenbeckstr. 1, Mainz, Germany hDepartment of Ophthalmology, University Hospital Bern, Bern, Switzerland iDardenne Eye Hospital, Bonn-Bad Godesberg, Germany.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1097/HJH.0000000000001380DOI Listing
August 2017

Acromioclavicular joint dislocation treated with Bosworth screw and additional K-wiring: results after 7.8 years - still an adequate procedure?

Authors:
Thomas M Tiefenboeck Domenik Popp Sandra Boesmueller Stephan Payr Julian Joestl Micha Komjati Harald Binder Mark Schurz Roman C Ostermann

BMC Musculoskelet Disord 2017 Aug 4;18(1):339. Epub 2017 Aug 4.

Department of Trauma Surgery, Medical University of Vienna, Waehringer Guertel 18-20, A-1090, Vienna, Austria.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1186/s12891-017-1692-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5545010PMC
August 2017

Identifying Prognostic SNPs in Clinical Cohorts: Complementing Univariate Analyses by Resampling and Multivariable Modeling.

Authors:
Stefanie Hieke Axel Benner Richard F Schlenk Martin Schumacher Lars Bullinger Harald Binder

PLoS One 2016 9;11(5):e0155226. Epub 2016 May 9.

Institute of Medical Biostatistics, Epidemiology and Informatics, University Medical Center Johannes Gutenberg University Mainz, Mainz, Germany.

View Article

Download full-text PDF

 Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0155226PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4861340PMC
July 2017

Noise Annoyance Is Associated with Depression and Anxiety in the General Population- The Contribution of Aircraft Noise.

Authors:
Manfred E Beutel Claus Jünger Eva M Klein Philipp Wild Karl Lackner Maria Blettner Harald Binder Matthias Michal Jörg Wiltink Elmar Brähler Thomas Münzel

PLoS One 2016 19;11(5):e0155357. Epub 2016 May 19.

Medical Clinic for Cardiology, Angiology and Intensive Care Medicine, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.

View Article

Download full-text PDF

 Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0155357PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4873188PMC
July 2017

Removing Batch Effects from Longitudinal Gene Expression - Quantile Normalization Plus ComBat as Best Approach for Microarray Transcriptome Data.

Authors:
Christian Müller Arne Schillert Caroline Röthemeier David-Alexandre Trégouët Carole Proust Harald Binder Norbert Pfeiffer Manfred Beutel Karl J Lackner Renate B Schnabel Laurence Tiret Philipp S Wild Stefan Blankenberg Tanja Zeller Andreas Ziegler

PLoS One 2016 7;11(6):e0156594. Epub 2016 Jun 7.

Institute of Medical Biometry and Statistics, University Medical Center Schleswig-Holstein, Campus Luebeck, Lübeck, 23562, Germany.

View Article

Download full-text PDF

 Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0156594PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4896498PMC
July 2017

A DAG-based comparison of interventional effect underestimation between composite endpoint and multi-state analysis in cardiovascular trials.

Authors:
Antje Jahn-Eimermacher Katharina Ingel Stella Preussler Antoni Bayes-Genis Harald Binder

BMC Med Res Methodol 2017 Jul 4;17(1):92. Epub 2017 Jul 4.

Institute of Medical Biostatistics, Epidemiology and Informatics, University Medical Center Johannes Gutenberg-University Mainz, Obere Zahlbacher Str. 69, Mainz, 55131, Germany.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1186/s12874-017-0366-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5496642PMC
July 2017

Relation between Arterial Stiffness and Markers of Inflammation and Hemostasis - Data from the Population-based Gutenberg Health Study.

Authors:
Natalie Arnold Tommaso Gori Renate B Schnabel Andreas Schulz Jürgen H Prochaska Tanja Zeller Harald Binder Norbert Pfeiffer Manfred Beutel Christine Espinola-Klein Karl J Lackner Stefan Blankenberg Thomas Münzel Philipp S Wild

Sci Rep 2017 07 24;7(1):6346. Epub 2017 Jul 24.

Preventive Cardiology and Preventive Medicine, Center for Cardiology, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1038/s41598-017-06175-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5524791PMC
July 2017

Integrating clinical decision support systems for pharmacogenomic testing into clinical routine - a scoping review of designs of user-system interactions in recent system development.

Authors:
Marc Hinderer Martin Boeker Sebastian A Wagner Martin Lablans Stephanie Newe Jan L Hülsemann Michael Neumaier Harald Binder Harald Renz Till Acker Hans-Ulrich Prokosch Martin Sedlmayr

BMC Med Inform Decis Mak 2017 Jun 6;17(1):81. Epub 2017 Jun 6.

Medical Informatics, Friedrich-Alexander-Universität Erlangen-Nürnberg, Wetterkreuz 13, 91058, Erlangen, Germany.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1186/s12911-017-0480-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5461630PMC
June 2017

The experience of physicians in pharmacogenomic clinical decision support within eight German university hospitals.

Authors:
Marc Hinderer Martin Boeker Sebastian A Wagner Harald Binder Frank Ückert Stephanie Newe Jan L Hülsemann Michael Neumaier Carmen Schade-Brittinger Till Acker Hans-Ulrich Prokosch Brita Sedlmayr

Pharmacogenomics 2017 Jun 8;18(8):773-785. Epub 2017 Jun 8.

Chair of Medical Informatics, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.2217/pgs-2017-0027DOI Listing
June 2017

Simulation of complex data structures for planning of studies with focus on biomarker comparison.

Authors:
Andreas Schulz Daniela Zöller Stefan Nickels Manfred E Beutel Maria Blettner Philipp S Wild Harald Binder

BMC Med Res Methodol 2017 Jun 13;17(1):90. Epub 2017 Jun 13.

Institute for Medical Biometry and Statistics, Faculty of Medicine and Medical Center - University of Freiburg, Stefan-Meier-Str. 26, Freiburg, 79104, Germany.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1186/s12874-017-0364-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5470184PMC
June 2017

Displaced juvenile Tillaux fractures : Surgical treatment and outcome.

Authors:
Thomas M Tiefenboeck Harald Binder Julian Joestl Michael M Tiefenboeck Sandra Boesmueller Christian Krestan Mark Schurz

Wien Klin Wochenschr 2017 Mar 17;129(5-6):169-175. Epub 2016 Aug 17.

Department of Trauma Surgery, Medical University Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1007/s00508-016-1059-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5346147PMC
March 2017

Both flow-mediated dilation and constriction are associated with changes in blood flow and shear stress: Two complementary perspectives on endothelial function.

Authors:
Tommaso Gori Urs von Henning Selina Muxel Sarina Schaefer Federica Fasola Marcus Vosseler Boris Schnorbus Harald Binder John D Parker Thomas Münzel

Clin Hemorheol Microcirc 2016 ;64(3):255-266

Kardiologie I, Zentrum für Kardiologie und DZHK Standort Rhein-Main, Mainz, Germany.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.3233/CH-168102DOI Listing
February 2017

Mean Platelet Volume and Arterial Stiffness - Clinical Relationship and Common Genetic Variability.

Authors:
Marina Panova-Noeva Natalie Arnold M Iris Hermanns Jürgen H Prochaska Andreas Schulz Henri M Spronk Harald Binder Norbert Pfeiffer Manfred Beutel Stefan Blankenberg Tanja Zeller Johannes Lotz Thomas Münzel Karl J Lackner Hugo Ten Cate Philipp S Wild

Sci Rep 2017 01 6;7:40229. Epub 2017 Jan 6.

Center for Thrombosis and Hemostasis (CTH), University Medical Center of the Johannes Gutenberg-University Mainz, Germany.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1038/srep40229DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5216402PMC
January 2017

Displaced Neer Type IIB distal-third clavicle fractures-Long-term clinical outcome after plate fixation and additional screw augmentation for coracoclavicular instability.

Authors:
Thomas M Tiefenboeck Sandra Boesmueller Harald Binder Adam Bukaty Michael M Tiefenboeck Julian Joestl Marcus Hofbauer Roman C Ostermann

BMC Musculoskelet Disord 2017 01 23;18(1):30. Epub 2017 Jan 23.

Department of Trauma Surgery, Medical University of Vienna, Waehringerguertel 18-20, 1090, Vienna, Austria.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1186/s12891-017-1398-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5259881PMC
January 2017

PREVALENCE AND ASSOCIATIONS OF MYELINATED RETINAL NERVE FIBERS: Results From the Population-Based Gutenberg Health Study.

Authors:
Hisham Elbaz Tunde Peto Christina Butsch Elias Orouji Dagmar Laubert-Reh Katharina A Ponto Harald Binder Norbert Pfeiffer Alireza Mirshahi

Retina 2016 Dec;36(12):2364-2370

*Department of Ophthalmology, University Medical Center Mainz, Mainz, Germany; †NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, United Kingdom; ‡Department of Ophthalmology, Philipps University of Marburg, Marburg, Germany; §Center for Thrombosis and Hemostasis (CTH), University Medical Center Mainz, Mainz, Germany; ¶Department of Biostatistics, University Medical Center Mainz, Mainz, Germany; and **Dardenne Eye Hospital, Bonn-Bad Godesberg, Germany.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1097/IAE.0000000000001093DOI Listing
December 2016

Prospective validation of a blood-based 9-miRNA profile for early detection of breast cancer in a cohort of women examined by clinical mammography.

Authors:
Maria B Lyng Annette R Kodahl Harald Binder Henrik J Ditzel

Mol Oncol 2016 12 1;10(10):1621-1626. Epub 2016 Nov 1.

Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark; Department of Oncology, Odense University Hospital, Odense, Denmark. Electronic address:

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.molonc.2016.10.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5423135PMC
December 2016

Late outcomes after acute pulmonary embolism: rationale and design of FOCUS, a prospective observational multicenter cohort study.

Authors:
Stavros V Konstantinides Stefano Barco Stephan Rosenkranz Mareike Lankeit Matthias Held Felix Gerhardt Leonard Bruch Ralf Ewert Martin Faehling Julia Freise Hossein-Ardeschir Ghofrani Ekkehard Grünig Michael Halank Nadine Heydenreich Marius M Hoeper Hanno H Leuchte Eckhard Mayer F Joachim Meyer Claus Neurohr Christian Opitz Antonio Pinto Hans-Jürgen Seyfarth Rolf Wachter Bianca Zäpf Heinrike Wilkens Harald Binder Philipp S Wild

J Thromb Thrombolysis 2016 Nov;42(4):600-9

Center for Thrombosis and Hemostasis, University Medical Center of the Johannes Gutenberg University, Langenbeckstrasse 1, Building 403, 55131, Mainz, Germany.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1007/s11239-016-1415-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5040729PMC
November 2016

Distribution of antiphospholipid antibodies in a large population-based German cohort.

Authors:
Davit Manukyan Heidi Rossmann Andreas Schulz Tanja Zeller Norbert Pfeiffer Harald Binder Thomas Münzel Manfred E Beutel Nadine Müller-Calleja Philipp S Wild Karl J Lackner

Clin Chem Lab Med 2016 Oct;54(10):1663-70

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1515/cclm-2016-0014DOI Listing
October 2016

Myopia and Cognitive Performance: Results From the Gutenberg Health Study.

Authors:
Alireza Mirshahi Katharina A Ponto Dagmar Laubert-Reh Benjamin Rahm Karl J Lackner Harald Binder Norbert Pfeiffer Josef M Unterrainer

Invest Ophthalmol Vis Sci 2016 Oct;57(13):5230-5236

Medical Psychology and Medical Sociology, University Medical Center Mainz, Germany 6Medical Psychology and Medical Sociology, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1167/iovs.16-19507DOI Listing
October 2016

Reply: Bioresorbable Scaffold Thrombosis: Why BRS Size Matters.

Authors:
Serban Puricel Florim Cucul Melissa Weissner Axel Schmermund Peiman Jamshidi Tobias Nyffenegger Harald Binder Holger Eggebrecht Thomas Münzel Stephane Cook Tommaso Gori

J Am Coll Cardiol 2016 08;68(5):572-573

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.jacc.2016.05.040DOI Listing
August 2016

Integrating multiple molecular sources into a clinical risk prediction signature by extracting complementary information.

Authors:
Stefanie Hieke Axel Benner Richard F Schlenl Martin Schumacher Lars Bullinger Harald Binder

BMC Bioinformatics 2016 Aug 30;17(1):327. Epub 2016 Aug 30.

Institute of Medical Biostatistics, Epidemiology and Informatics, University Medical Center Johannes Gutenberg University Mainz, Obere Zahlbacher Str. 69, Mainz, 55131, Germany.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1186/s12859-016-1183-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5004308PMC
August 2016

Home treatment of patients with low-risk pulmonary embolism with the oral factor Xa inhibitor rivaroxaban. Rationale and design of the HoT-PE Trial.

Authors:
Stefano Barco Mareike Lankeit Harald Binder Sebastian Schellong Michael Christ Jan Beyer-Westendorf Daniel Duerschmied Rupert Bauersachs Klaus Empen Matthias Held Martin Schwaiblmair Cândida Fonseca David Jiménez Cecilia Becattini Kurt Quitzau Stavros Konstantinides

Thromb Haemost 2016 07 24;116(1):191-7. Epub 2016 Mar 24.

Stavros V. Konstantinides, MD, FESC, Center for Thrombosis and Hemostasis, University Medical Center Mainz, Langenbeckstrasse 1, Building 403, 55131 Mainz, Germany, Tel.: +49 6131 17 8382, Fax: +49 6131 17 3456, E-mail:

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1160/TH16-01-0004DOI Listing
July 2016

Antiphospholipid antibodies in a large population-based cohort: genome-wide associations and effects on monocyte gene expression.

Authors:
Nadine Müller-Calleja Heidi Rossmann Christian Müller Philipp Wild Stefan Blankenberg Norbert Pfeiffer Harald Binder Manfred E Beutel Davit Manukyan Tanja Zeller Karl J Lackner

Thromb Haemost 2016 07 21;116(1):115-23. Epub 2016 Apr 21.

Dr. Karl J. Lackner, Institute of Clinical Chemistry and Laboratory Medicine, University Medical Center Mainz, Langenbeckstrasse 1, D-55131 Mainz, Germany, Tel.: +49 6131 177190, E-mail:

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1160/TH15-12-0947DOI Listing
July 2016

Distribution of Anterior Chamber Angle Width and Correlation With Age, Refraction, and Anterior Chamber Depth-The Gutenberg Health Study.

Authors:
Alexander K Schuster Norbert Pfeiffer Stefan Nickels Andreas Schulz René Höhn Philipp S Wild Harald Binder Thomas Münzel Manfred E Beutel Urs Vossmerbaeumer

Invest Ophthalmol Vis Sci 2016 Jul;57(8):3740-6

Department of Ophthalmology University Medical Center Mainz, Mainz, Germany.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1167/iovs.16-19600DOI Listing
July 2016

Dealing with prognostic signature instability: a strategy illustrated for cardiovascular events in patients with end-stage renal disease.

Authors:
Harald Binder Thorsten Kurz Sven Teschner Clemens Kreutz Marcel Geyer Johannes Donauer Annette Kraemer-Guth Jens Timmer Martin Schumacher Gerd Walz

BMC Med Genomics 2016 07 20;9(1):43. Epub 2016 Jul 20.

Renal Division, Department of Medicine, University Hospital Freiburg, Freiburg, Germany.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1186/s12920-016-0210-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4955222PMC
July 2016

Tracheostomy following anterior cervical spine fusion in trauma patients.

Authors:
Harald Binder Nikolaus Lang Thomas M Tiefenboeck Adam Bukaty Stefan Hajdu Kambiz Sarahrudi

Int Orthop 2016 Jun 21;40(6):1157-62. Epub 2015 Jul 21.

Department of Trauma Surgery, Medical University of Vienna, Waehringerguertel 18-20, 1090, Vienna, Austria.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1007/s00264-015-2913-5DOI Listing
June 2016

Depression, anxiety and quality of life in long-term survivors of malignant melanoma: a register-based cohort study.

Authors:
Manfred E Beutel Sabine Fischbeck Harald Binder Maria Blettner Elmar Brähler Katharina Emrich Peter Friedrich-Mai Barbara H Imruck Veronika Weyer Sylke R Zeissig

PLoS One 2015 23;10(1):e0116440. Epub 2015 Jan 23.

Institute for Medical Biostatistics, Epidemiology and Informatics (IMBEI), University Medical Center Mainz, Mainz, Germany.

View Article

Download full-text PDF

 Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0116440PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4304781PMC
May 2016

Psychosocial Care Needs of Melanoma Survivors: Are They Being Met?

Authors:
Sabine Fischbeck Barbara H Imruck Maria Blettner Veronika Weyer Harald Binder Sylke R Zeissig Katharina Emrich Peter Friedrich-Mai Manfred E Beutel

PLoS One 2015 21;10(8):e0132754. Epub 2015 Aug 21.

Department of Psychosomatic Medicine and Psychotherapy, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany.

View Article

Download full-text PDF

 Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0132754PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4546620PMC
May 2016

Pitfalls of hypothesis tests and model selection on bootstrap samples: Causes and consequences in biometrical applications.

Authors:
Silke Janitza Harald Binder Anne-Laure Boulesteix

Biom J 2016 May 15;58(3):447-73. Epub 2015 Sep 15.

Department of Medical Informatics, Biometry and Epidemiology, University of Munich, Marchioninistr. 15, 81377 Munich, Germany.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1002/bimj.201400246DOI Listing
May 2016

The Difference between Growth Factor Expression after Single and Multiple Fractures: Preliminary Results in Human Fracture Healing.

Authors:
Harald Binder Stefan Eipeldauer Markus Gregori Leonard Höchtl-Lee Anita Thomas Thomas M Tiefenboeck Stefan Hajdu Kambiz Sarahrudi

Dis Markers 2015 13;2015:203136. Epub 2015 Jul 13.

Department of Trauma Surgery, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1155/2015/203136DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4515527PMC
April 2016

Systematically evaluating interfaces for RNA-seq analysis from a life scientist perspective.

Authors:
Alicia Poplawski Federico Marini Moritz Hess Tanja Zeller Johanna Mazur Harald Binder

Brief Bioinform 2016 Mar 23;17(2):213-23. Epub 2015 Jun 23.

View Article

Download full-text PDF

 Source
https://academic.oup.com/bib/article-lookup/doi/10.1093/bib/
Publisher Site
http://dx.doi.org/10.1093/bib/bbv036DOI Listing
March 2016

Stagewise pseudo-value regression for time-varying effects on the cumulative incidence.

Authors:
Daniela Zöller Irene Schmidtmann Arndt Weinmann Thomas A Gerds Harald Binder

Stat Med 2016 Mar 28;35(7):1144-58. Epub 2015 Oct 28.

Institute of Medical Biostatistics, Epidemiology and Informatics, University Medical Center, Johannes Gutenberg University Mainz, 55101, Mainz, Germany.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1002/sim.6770DOI Listing
March 2016

Bioresorbable Coronary Scaffold Thrombosis: Multicenter Comprehensive Analysis of Clinical Presentation, Mechanisms, and Predictors.

Authors:
Serban Puricel Florim Cuculi Melissa Weissner Axel Schmermund Peiman Jamshidi Tobias Nyffenegger Harald Binder Holger Eggebrecht Thomas Münzel Stephane Cook Tommaso Gori

J Am Coll Cardiol 2016 Mar;67(8):921-31

Zentrum für Kardiologie, University Hospital Mainz, Mainz, Germany, and German Center for Cardiac and Vascular Research (DZHK), Standort Rhein-Main, Mainz, Germany. Electronic address:

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.jacc.2015.12.019DOI Listing
March 2016

Treatment of proximal humerus fractures in children and young adolescents.

Authors:
Harald Binder Thomas M Tiefenboeck Stephan Payr Mark Schurz Silke Aldrian Kambiz Sarahrudi

Wien Klin Wochenschr 2016 Feb 6;128(3-4):120-4. Epub 2015 Nov 6.

Department of Trauma Surgery, Medical University Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1007/s00508-015-0879-3DOI Listing
February 2016

Disease Burden of Rotavirus Gastroenteritis in Children Residing in Germany: A Retrospective, Hospital-based Surveillance.

Authors:
Frank Kowalzik Fred Zepp Isabell Hoffmann Harald Binder Dagmar Lautz Reyn van Ewijk Markus Knuf Tobias Tenenbaum Martin Laass Thorsten Reuter Renate Schulze-Rath Manuela Marron

Pediatr Infect Dis J 2016 Jan;35(1):97-103

From the *Pediatric Department and †Institute of Medical Biostatistics, Epidemiology and Informatics (IMBEI), University Medical Center of the Johannes Gutenberg University, Mainz, Germany; ‡Johannes Gutenberg University Mainz, Faculty of Economics, Mainz, Germany; §Klinikum der Landeshauptstadt Wiesbaden HSK, Dr Horst Schmidt Kliniken, Wiesbaden, Germany; ¶Pediatric Infectious Diseases, Department of Pediatrics, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany; ‖Pediatric Department, University Hospital Carl Gustav Carus, Dresden, Germany; **Sanofi Pasteur MSD GmbH, Leimen, Germany; and ††Institute for Community Medicine, University Medicine of the Ernst-Moritz-Arndt University, Greifswald, Germany.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1097/INF.0000000000000939DOI Listing
January 2016

Sex-specific differences in genetic and nongenetic determinants of mean platelet volume: results from the Gutenberg Health Study.

Authors:
Marina Panova-Noeva Andreas Schulz M Iris Hermanns Vera Grossmann Evgenia Pefani Henri M H Spronk Dagmar Laubert-Reh Harald Binder Manfred Beutel Norbert Pfeiffer Stefan Blankenberg Tanja Zeller Thomas Münzel Karl J Lackner Hugo Ten Cate Philipp S Wild

Blood 2016 Jan 30;127(2):251-9. Epub 2015 Oct 30.

Center of Thrombosis and Hemostasis, Preventive Cardiology and Medical Prevention, Department of Medicine II, and DZHK, Partner Site Rhein-Main, Mainz, Germany; and.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1182/blood-2015-07-660308DOI Listing
January 2016

A meta-analysis of 120 246 individuals identifies 18 new loci for fibrinogen concentration.

Authors:
Paul S de Vries Daniel I Chasman Maria Sabater-Lleal Ming-Huei Chen Jennifer E Huffman Maristella Steri Weihong Tang Alexander Teumer Riccardo E Marioni Vera Grossmann Jouke J Hottenga Stella Trompet Martina Müller-Nurasyid Jing Hua Zhao Jennifer A Brody Marcus E Kleber Xiuqing Guo Jie Jin Wang Paul L Auer John R Attia Lisa R Yanek Tarunveer S Ahluwalia Jari Lahti Cristina Venturini Toshiko Tanaka Lawrence F Bielak Peter K Joshi Ares Rocanin-Arjo Ivana Kolcic Pau Navarro Lynda M Rose Christopher Oldmeadow Helene Riess Johanna Mazur Saonli Basu Anuj Goel Qiong Yang Mohsen Ghanbari Gonneke Willemsen Ann Rumley Edoardo Fiorillo Anton J M de Craen Anne Grotevendt Robert Scott Kent D Taylor Graciela E Delgado Jie Yao Annette Kifley Charles Kooperberg Rehan Qayyum Lorna M Lopez Tina L Berentzen Katri Räikkönen Massimo Mangino Stefania Bandinelli Patricia A Peyser Sarah Wild David-Alexandre Trégouët Alan F Wright Jonathan Marten Tatijana Zemunik Alanna C Morrison Bengt Sennblad Geoffrey Tofler Moniek P M de Maat Eco J C de Geus Gordon D Lowe Magdalena Zoledziewska Naveed Sattar Harald Binder Uwe Völker Melanie Waldenberger Kay-Tee Khaw Barbara Mcknight Jie Huang Nancy S Jenny Elizabeth G Holliday Lihong Qi Mark G Mcevoy Diane M Becker John M Starr Antti-Pekka Sarin Pirro G Hysi Dena G Hernandez Min A Jhun Harry Campbell Anders Hamsten Fernando Rivadeneira Wendy L Mcardle P Eline Slagboom Tanja Zeller Wolfgang Koenig Bruce M Psaty Talin Haritunians Jingmin Liu Aarno Palotie André G Uitterlinden David J Stott Albert Hofman Oscar H Franco Ozren Polasek Igor Rudan Pierre-Emmanuel Morange James F Wilson Sharon L R Kardia Luigi Ferrucci Tim D Spector Johan G Eriksson Torben Hansen Ian J Deary Lewis C Becker Rodney J Scott Paul Mitchell Winfried März Nick J Wareham Annette Peters Andreas Greinacher Philipp S Wild J Wouter Jukema Dorret I Boomsma Caroline Hayward Francesco Cucca Russell Tracy Hugh Watkins Alex P Reiner Aaron R Folsom Paul M Ridker Christopher J O'Donnell Nicholas L Smith David P Strachan Abbas Dehghan

Hum Mol Genet 2016 Jan 10;25(2):358-70. Epub 2015 Nov 10.

Department of Epidemiology,

View Article

Download full-text PDF

 Source
http://hmg.oxfordjournals.org/content/early/2015/12/08/hmg.d
Web Search
http://www.hmg.oxfordjournals.org/lookup/doi/10.1093/hmg/ddv
Publisher Site
http://dx.doi.org/10.1093/hmg/ddv454DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4715256PMC
January 2016

Gene expression patterns underlying parasite-induced alterations in host behaviour and life history.

Authors:
Barbara Feldmeyer Johanna Mazur Sara Beros Hannes Lerp Harald Binder Susanne Foitzik

Mol Ecol 2016 01 19;25(2):648-60. Epub 2016 Jan 19.

Evolutionary Biology, Johannes Gutenberg University Mainz, Johannes-von-Müller-Weg 6, 55128, Mainz, Germany.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1111/mec.13498DOI Listing
January 2016

Molecular cause and functional impact of altered synaptic lipid signaling due to a prg-1 gene SNP.

Authors:
Johannes Vogt Jenq-Wei Yang Arian Mobascher Jin Cheng Yunbo Li Xingfeng Liu Jan Baumgart Carine Thalman Sergei Kirischuk Petr Unichenko Guilherme Horta Konstantin Radyushkin Albrecht Stroh Sebastian Richers Nassim Sahragard Ute Distler Stefan Tenzer Lianyong Qiao Klaus Lieb Oliver Tüscher Harald Binder Nerea Ferreiros Irmgard Tegeder Andrew J Morris Sergiu Gropa Peter Nürnberg Mohammad R Toliat Georg Winterer Heiko J Luhmann Jisen Huai Robert Nitsch

EMBO Mol Med 2016 Jan;8(1):25-38

Institute for Microscopic Anatomy and Neurobiology, University Medical Center, Johannes Gutenberg-University, Mainz, Germany

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.15252/emmm.201505677DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4718157PMC
January 2016

Macrophage activation in acute exacerbation of idiopathic pulmonary fibrosis.

Authors:
Jonas Christian Schupp Harald Binder Benedikt Jäger Giuseppe Cillis Gernot Zissel Joachim Müller-Quernheim Antje Prasse

PLoS One 2015 15;10(1):e0116775. Epub 2015 Jan 15.

Department of Pneumology, University Medical Centre, Freiburg, Germany.

View Article

Download full-text PDF

 Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0116775PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4295887PMC
December 2015

Genome-wide significant association with seven novel multiple sclerosis risk loci.

Authors:
Christina M Lill Felix Luessi Antonio Alcina Ekaterina A Sokolova Nerea Ugidos Belén de la Hera Léna Guillot-Noël Sunny Malhotra Eva Reinthaler Brit-Maren M Schjeide Julia Y Mescheriakova Andriy Mashychev Inken Wohlers Denis A Akkad Orhan Aktas Iraide Alloza Alfredo Antigüedad Rafa Arroyo Ianire Astobiza Paul Blaschke Alexei N Boyko Mathias Buttmann Andrew Chan Thomas Dörner Joerg T Epplen Olga O Favorova Maria Fedetz Oscar Fernández Angel García-Martínez Lisa-Ann Gerdes Christiane Graetz Hans-Peter Hartung Sabine Hoffjan Guillermo Izquierdo Denis S Korobko Antje Kroner Christian Kubisch Tania Kümpfel Laura Leyva Peter Lohse Nadezhda A Malkova Xavier Montalban Ekaterina V Popova Peter Rieckmann Alexei S Rozhdestvenskii Christiane Schmied Inna V Smagina Ekaterina Y Tsareva Alexander Winkelmann Uwe K Zettl Harald Binder Isabelle Cournu-Rebeix Rogier Hintzen Alexander Zimprich Manuel Comabella Bertrand Fontaine Elena Urcelay Koen Vandenbroeck Maxim Filipenko Fuencisla Matesanz Frauke Zipp Lars Bertram

J Med Genet 2015 Dec 16;52(12):848-55. Epub 2015 Oct 16.

Platform for Genome Analytics, Institutes of Neurogenetics & Integrative and Experimental Genomics, University of Lübeck, Lübeck, Germany Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Berlin, Germany Department of Medicine, School of Public Health, Imperial College London, London, UK.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1136/jmedgenet-2015-103442DOI Listing
December 2015

Sex Differences in Correlates of Intermediate Phenotypes and Prevalent Cardiovascular Disease in the General Population.

Authors:
Renate B Schnabel Philipp S Wild Jürgen H Prochaska Francisco M Ojeda Tanja Zeller Nargiz Rzayeva Ariana Ebrahim Karl J Lackner Manfred E Beutel Norbert Pfeiffer Christoph R Sinning Sabine Oertelt-Prigione Vera Regitz-Zagrosek Harald Binder Thomas Münzel Stefan Blankenberg

Front Cardiovasc Med 2015 15;2:15. Epub 2015 Apr 15.

Department of General and Interventional Cardiology, University Heart Center Hamburg-Eppendorf , Hamburg , Germany.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.3389/fcvm.2015.00015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4671364PMC
December 2015

Large platelets but not putative endothelial progenitor cells are associated with low strut coverage after drug-eluting stent implantation.

Authors:
Thomas G Nührenberg Min Zhao Christian Stratz Michael Amann Christian M Valina Michael Gick Dietmar Trenk Harald Binder Heinz Joachim Büttner Franz-Josef Neumann

Int J Cardiol 2015 Nov 29;199:358-65. Epub 2015 Jul 29.

Universitäts-Herzzentrum Freiburg • Bad Krozingen, Klinik für Kardiologie und Angiologie II, Südring 15, D-79189 Bad Krozingen, Germany.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.ijcard.2015.07.062DOI Listing
November 2015

Alterations in circulating miRNA levels following early-stage estrogen receptor-positive breast cancer resection in post-menopausal women.

Authors:
Annette R Kodahl Pernille Zeuthen Harald Binder Ann S Knoop Henrik J Ditzel

PLoS One 2014 8;9(7):e101950. Epub 2014 Jul 8.

Department of Oncology, Odense University Hospital and University of Southern Denmark, Odense, Denmark; Department of Cancer and Inflammation, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark.

View Article

Download full-text PDF

 Source
https://pdfs.semanticscholar.org/c1b5/328439ea2fb3b0610afe1d
Web Search
http://dx.plos.org/10.1371/journal.pone.0101950
Publisher Site
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0101950PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4086980PMC
October 2015

Is sonic Hedgehog involved in human fracture healing? --a prospective study on local and systemic concentrations of SHH.

Authors:
Stefan Eipeldauer Anita Thomas Leonard Hoechtl-Lee Mathias Kecht Harald Binder Julia Koettstorfer Markus Gregori Kambiz Sarahrudi

PLoS One 2014 11;9(12):e114668. Epub 2014 Dec 11.

University Clinic for Traumatology, Medical University of Vienna, Vienna, Austria.

View Article

Download full-text PDF

 Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0114668PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4263617PMC
October 2015

A weighting approach for judging the effect of patient strata on high-dimensional risk prediction signatures.

Authors:
Veronika Weyer Harald Binder

BMC Bioinformatics 2015 Sep 15;16:294. Epub 2015 Sep 15.

Institute of Medical Biostatistics, Epidemiology and Informatics (IMBEI), University Medical Center Mainz, Johannes Gutenberg-University Mainz, Obere Zahlbacher Strasse 69, Mainz, Germany.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1186/s12859-015-0716-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4572441PMC
September 2015

Prevalence, Phenotype, and Psychosocial Well-Being in Euthyroid/Hypothyroid Thyroid-Associated Orbitopathy.

Authors:
Katharina A Ponto Harald Binder Tanja Diana Nina Matheis Anna F Otto Susanne Pitz Norbert Pfeiffer George J Kahaly

Thyroid 2015 Aug 4;25(8):942-8. Epub 2015 Jun 4.

4 Department of Medicine I, Johannes Gutenberg University Medical Center , Mainz, Germany .

View Article

Download full-text PDF

 Source
https://www.liebertpub.com/doi/10.1089/thy.2015.0031
Publisher Site
http://dx.doi.org/10.1089/thy.2015.0031DOI Listing
August 2015

On stability issues in deriving multivariable regression models.

Authors:
Willi Sauerbrei Anika Buchholz Anne-Laure Boulesteix Harald Binder

Biom J 2015 Jul 15;57(4):531-55. Epub 2014 Dec 15.

Institut für Medizinische Biometrie, Epidemiologie und Informatik, Universitätsmedizin der Johannes-Gutenberg-Universität Mainz, Obere Zahlbacher Straße 69, 55131, Mainz, Germany.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1002/bimj.201300222DOI Listing
July 2015

Genetic Cell Ablation Reveals Clusters of Local Self-Renewing Microglia in the Mammalian Central Nervous System.

Authors:
Julia Bruttger Khalad Karram Simone Wörtge Tommy Regen Federico Marini Nicola Hoppmann Matthias Klein Thomas Blank Simon Yona Yochai Wolf Matthias Mack Emmanuel Pinteaux Werner Müller Frauke Zipp Harald Binder Tobias Bopp Marco Prinz Steffen Jung Ari Waisman

Immunity 2015 Jul 7;43(1):92-106. Epub 2015 Jul 7.

Institute for Molecular Medicine, University Medical Center of the Johannes Gutenberg-University Mainz, Obere Zahlbacher Str. 67, 55131 Mainz, Germany. Electronic address:

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.immuni.2015.06.012DOI Listing
July 2015

[Follow-up after acute pulmonary embolism. A prospective non-interventional multi-center cohort study (FOCUS)].

Authors:
Stavros V Konstantinides Mareike Lankeit Philipp Wild Kurt Quitzau Harald Binder

Dtsch Med Wochenschr 2015 Jun 11;140 Suppl 1:S20-1. Epub 2015 Jun 11.

Institut für Medizinische Biometrie, Epidemiologie und Informatik, Universitätsmedizin Mainz.

View Article

Download full-text PDF

 Source
http://www.thieme-connect.de/DOI/DOI?10.1055/s-0041-101767
Publisher Site
http://dx.doi.org/10.1055/s-0041-101767DOI Listing
June 2015

Impact of Parkinson's disease risk loci on age at onset.

Authors:
Christina M Lill Johnni Hansen Jørgen H Olsen Harald Binder Beate Ritz Lars Bertram

Mov Disord 2015 May 25;30(6):847-50. Epub 2015 Apr 25.

Platform for Genome Analytics, Institutes of Neurogenetics & Integrative and Experimental Genomics, University of Lübeck, Lübeck, Germany.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1002/mds.26237DOI Listing
May 2015

The prevalence of amblyopia in Germany: data from the prospective, population-based Gutenberg Health Study.

Authors:
Heike M Elflein Susanne Fresenius Julia Lamparter Susanne Pitz Norbert Pfeiffer Harald Binder Philipp Wild Alireza Mirshahi

Dtsch Arztebl Int 2015 May;112(19):338-44

Department of Ophthalmology at the University Medical Center of the Johannes Gutenberg University Mainz, Institute of Medical Biostatistics, Epidemiology and Informatics (IMBEI) at the University Medical Center of the Johannes Gutenberg University Mainz, Department of Germany Preventive Cardiology and Preventive Medicine, Center for Thrombosis and Hemostasis, German Center for Cardiovascular Disease (DZHK) at the University Medical Center of the Johannes Gutenberg University Mainz.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.3238/arztebl.2015.0338DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4458790PMC
May 2015

High-sensitivity cardiac troponin I in the general population--defining reference populations for the determination of the 99th percentile in the Gutenberg Health Study.

Authors:
Tanja Zeller Francisco Ojeda Fabian J Brunner Philipp Peitsmeyer Thomas Münzel Harald Binder Norbert Pfeiffer Matthias Michal Philipp S Wild Stefan Blankenberg Karl J Lackner

Clin Chem Lab Med 2015 Apr;53(5):699-706

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1515/cclm-2014-0619DOI Listing
April 2015

Simulating recurrent event data with hazard functions defined on a total time scale.

Authors:
Antje Jahn-Eimermacher Katharina Ingel Ann-Kathrin Ozga Stella Preussler Harald Binder

BMC Med Res Methodol 2015 Mar 8;15:16. Epub 2015 Mar 8.

Institute of Medical Biostatistics, Epidemiology and Informatics, University Medical Center Johannes Gutenberg University Mainz, Obere Zahlbacher Str. 69, Mainz, 55131, Germany.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1186/s12874-015-0005-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4387664PMC
March 2015

Big data in medical science--a biostatistical view.

Authors:
Harald Binder Maria Blettner

Dtsch Arztebl Int 2015 Feb;112(9):137-42

Institute of Medical Biostatistics, Epidemiology and Informatics (IMBEI) at the University Medical Center of the Johannes Gutenberg University Mainz.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.3238/arztebl.2015.0137DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4381554PMC
February 2015

Morphology and Progression in Primary Varicose Vein Disorder Due to 677C>T and 1298A>C Variants of MTHFR.

Authors:
Christoph Wilmanns Alexis Cooper Leesa Wockner Sotirios Katsandris Nadine Glaser Alexander Meyer Oliver Bartsch Harald Binder Paul Karl Walter Ulrich Zechner

EBioMedicine 2015 Feb 15;2(2):158-64. Epub 2015 Jan 15.

Institute of Human Genetics, University Medical Center of the Johannes Gutenberg University Mainz, 55131 Mainz, Germany.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.ebiom.2015.01.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4484817PMC
February 2015

Nighttime aircraft noise impairs endothelial function and increases blood pressure in patients with or at high risk for coronary artery disease.

Authors:
Frank Schmidt Kristoffer Kolle Katharina Kreuder Boris Schnorbus Philip Wild Marlene Hechtner Harald Binder Tommaso Gori Thomas Münzel

Clin Res Cardiol 2015 Jan 22;104(1):23-30. Epub 2014 Aug 22.

2 Medical Clinic, Cardiology, University Medical Center Mainz, Johannes Gutenberg University, Langenbeckstrasse 1, 55131, Mainz, Germany.

View Article

Download full-text PDF

 Source
http://link.springer.com/10.1007/s00392-014-0751-x
Publisher Site
http://dx.doi.org/10.1007/s00392-014-0751-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4300412PMC
January 2015

Translating bioinformatics in oncology: guilt-by-profiling analysis and identification of KIF18B and CDCA3 as novel driver genes in carcinogenesis.

Authors:
Timo Itzel Peter Scholz Thorsten Maass Markus Krupp Jens U Marquardt Susanne Strand Diana Becker Frank Staib Harald Binder Stephanie Roessler Xin Wei Wang Snorri Thorgeirsson Martina Müller Peter R Galle Andreas Teufel

Bioinformatics 2015 Jan 18;31(2):216-24. Epub 2014 Sep 18.

Department of Medicine I, University of Regensburg, 93053, Regensburg, Department of Medicine I, Institute of Medical Biostatistics, Epidemiology and Informatics (IMBEI), University Medical Center, Johannes Gutenberg University, 55131, Mainz, Department of Pathology, University of Heidelberg, 69120, Germany and Laboratory of Experimental Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, 20892 MD, USA.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1093/bioinformatics/btu586DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4287940PMC
January 2015

Visualizing inconsistency in network meta-analysis by independent path decomposition.

Authors:
Ulrike Krahn Harald Binder Jochem König

BMC Med Res Methodol 2014 Dec 16;14:131. Epub 2014 Dec 16.

Institute of Medical Biostatistics, Epidemiology and Informatics, University Medical Center Johannes Gutenberg University Mainz, Langenbeckstr, 1, 55101 Mainz, Germany.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1186/1471-2288-14-131DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4279676PMC
December 2014

Clinical and radiological long-term outcomes after matrix-induced autologous chondrocyte transplantation: a prospective follow-up at a minimum of 10 years.

Authors:
Silke Aldrian Lukas Zak Barbara Wondrasch Christian Albrecht Beate Stelzeneder Harald Binder Florian Kovar Siegfried Trattnig Stefan Marlovits

Am J Sports Med 2014 Nov 9;42(11):2680-8. Epub 2014 Sep 9.

Department of Trauma Surgery, Medical University of Vienna, Vienna, Austria.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1177/0363546514548160DOI Listing
November 2014

Quality of life in Parkinson's disease patients with motor fluctuations and dyskinesias in five European countries.

Authors:
Marlene C Hechtner Thomas Vogt York Zöllner Sabrina Schröder Julia B Sauer Harald Binder Susanne Singer Rafael Mikolajczyk

Parkinsonism Relat Disord 2014 Sep 10;20(9):969-74. Epub 2014 Jun 10.

Department of Epidemiology, Helmholtz Centre for Infection Research, Braunschweig, Germany; Hannover Medical School, Hannover, Germany.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.parkreldis.2014.06.001DOI Listing
September 2014

What subject matter questions motivate the use of machine learning approaches compared to statistical models for probability prediction?

Authors:
Harald Binder

Biom J 2014 Jul 25;56(4):584-7. Epub 2014 Feb 25.

Institute of Medical Biostatistics, Epidemiology and Informatics, University Medical Center, Johannes Gutenberg University Mainz, 55101 Mainz, Germany.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1002/bimj.201300218DOI Listing
July 2014

Novel circulating microRNA signature as a potential non-invasive multi-marker test in ER-positive early-stage breast cancer: a case control study.

Authors:
Annette R Kodahl Maria B Lyng Harald Binder Søren Cold Karina Gravgaard Ann S Knoop Henrik J Ditzel

Mol Oncol 2014 Jul 16;8(5):874-83. Epub 2014 Mar 16.

Department of Oncology, Odense University Hospital, Odense, Denmark; University of Southern Denmark, Odense, Denmark; Department of Cancer and Inflammation, Institute of Molecular Medicine, University of Southern Denmark, Denmark. Electronic address:

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.molonc.2014.03.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5528529PMC
July 2014

Early retirement in cancer patients with or without comorbid mental health conditions: a prospective cohort study.

Authors:
Susanne Singer Alexandra Meyer Sabine Wienholz Susanne Briest Anna Brown Andreas Dietz Harald Binder Sven Jonas Kirsten Papsdorf Jens-Uwe Stolzenburg Uwe Köhler Jörg Raßler Rüdiger Zwerenz Katharina Schröter Anja Mehnert Margrit Löbner Hans-Helmut König Steffi G Riedel-Heller

Cancer 2014 Jul 18;120(14):2199-206. Epub 2014 Apr 18.

Institute of Medical Biostatistics, Epidemiology, and Informatics, University Medical Center, Mainz, Germany; Division of Psychosocial Oncology, University of Leipzig, Leipzig, Germany.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1002/cncr.28716DOI Listing
July 2014

A boosting approach for adapting the sparsity of risk prediction signatures based on different molecular levels.

Authors:
Murat Sariyar Martin Schumacher Harald Binder

Stat Appl Genet Mol Biol 2014 Jun;13(3):343-57

View Article

Download full-text PDF

 Source
https://www.degruyter.com/view/j/sagmb.2014.13.issue-3/sagmb
Publisher Site
http://dx.doi.org/10.1515/sagmb-2013-0050DOI Listing
June 2014

Potential prognostic factors predicting secondary amputation in third-degree open lower limb fractures.

Authors:
Alexandra Fochtmann Martina Mittlböck Harald Binder Julia Köttstorfer Stefan Hajdu

J Trauma Acute Care Surg 2014 Apr;76(4):1076-81

From the University Clinic of Trauma Surgery, General Hospital (A.F., H.B., J.K., S.H.), and Section for Clinical Biometrics (M.M.), Center for Medical Statistics, Informatics and Intelligent Systems, Medical University of Vienna, Vienna, Austria.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1097/TA.0000000000000154DOI Listing
April 2014