Publications by authors named "Haoyi Wang"

65Publications

Recent advances of genome editing and related technologies in China.

Authors:
Wen Sun Haoyi Wang

Gene Ther 2020 Aug 3;27(7-8):312-320. Epub 2020 Aug 3.

State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, 100101, Beijing, China.

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http://dx.doi.org/10.1038/s41434-020-0181-5DOI Listing
August 2020

Overcoming Autocrine FGF Signaling-Induced Heterogeneity in Naive Human ESCs Enables Modeling of Random X Chromosome Inactivation.

Cell Stem Cell 2020 Sep 15;27(3):482-497.e4. Epub 2020 Jul 15.

State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China; University of Chinese Academy of Sciences, Beijing 100049, China; Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing 100101, China. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2020.06.002DOI Listing
September 2020

Effect of germination potential on storage lipids and transcriptome changes in premature developing seeds of oilseed rape (Brassica napus L.).

Theor Appl Genet 2020 Oct 2;133(10):2839-2852. Epub 2020 Jul 2.

Institute of Crop Science, Zhejiang University, Yu-Hang-Tang Road 866, Hangzhou, 310058, China.

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http://dx.doi.org/10.1007/s00122-020-03636-7DOI Listing
October 2020

Elevating seed oil content in a polyploid crop by induced mutations in SEED FATTY ACID REDUCER genes.

Plant Biotechnol J 2020 Mar 26. Epub 2020 Mar 26.

Plant Breeding Institute, Christian-Albrechts-University of Kiel, Kiel, Germany.

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http://dx.doi.org/10.1111/pbi.13381DOI Listing
March 2020

Recent advances in CRISPR research.

Protein Cell 2020 Mar 21. Epub 2020 Mar 21.

State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China.

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http://dx.doi.org/10.1007/s13238-020-00704-yDOI Listing
March 2020

Engineering T Cells Using CRISPR/Cas9 for Cancer Therapy.

Methods Mol Biol 2020 ;2115:419-433

State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.

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http://dx.doi.org/10.1007/978-1-0716-0290-4_23DOI Listing
January 2020

TGF-β inhibition via CRISPR promotes the long-term efficacy of CAR T cells against solid tumors.

JCI Insight 2020 02 27;5(4). Epub 2020 Feb 27.

State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.

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http://dx.doi.org/10.1172/jci.insight.133977DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7101140PMC
February 2020

The prognostic role of circulating CD8 T cell proliferation in patients with untreated extensive stage small cell lung cancer.

J Transl Med 2019 12 3;17(1):402. Epub 2019 Dec 3.

Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong University, Jinan, China.

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http://dx.doi.org/10.1186/s12967-019-02160-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6892179PMC
December 2019

Great efficacy of afatinib on a patient with lung adenocarcinoma harboring uncommon EGFR delE709_T710insD mutations: a case report.

Onco Targets Ther 2019 10;12:7399-7404. Epub 2019 Sep 10.

Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, People's Republic of China.

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http://dx.doi.org/10.2147/OTT.S221638DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6752199PMC
September 2019

Argonaute proteins from human gastrointestinal bacteria catalyze DNA-guided cleavage of single- and double-stranded DNA at 37 °C.

Cell Discov 2019 30;5:38. Epub 2019 Jul 30.

1State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, 100101 Beijing, China.

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http://dx.doi.org/10.1038/s41421-019-0105-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6796838PMC
July 2019

Therapeutic Effect Of First-Line EGFR-TKIs Combined With Concurrent Cranial Radiotherapy On NSCLC Patients With EGFR Activating Mutation And Brain Metastasis: A Retrospective Study.

Onco Targets Ther 2019 8;12:8311-8318. Epub 2019 Oct 8.

Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, People's Republic of China.

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http://dx.doi.org/10.2147/OTT.S223216DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6790348PMC
October 2019

Gene-edited babies: What went wrong and what could go wrong.

Authors:
Haoyi Wang Hui Yang

PLoS Biol 2019 04 30;17(4):e3000224. Epub 2019 Apr 30.

Institute of Neuroscience, State Key Laboratory of Neuroscience, Key Laboratory of Primate Neurobiology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China.

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http://dx.doi.org/10.1371/journal.pbio.3000224DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6490877PMC
April 2019

In vitro transcribed sgRNA causes cell death by inducing interferon release.

Protein Cell 2019 06;10(6):461-465

State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China.

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http://dx.doi.org/10.1007/s13238-018-0605-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6538590PMC
June 2019

Risk factors for brain metastases in patients with non-small-cell lung cancer.

Cancer Med 2018 12 8;7(12):6357-6364. Epub 2018 Nov 8.

Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong Academy of Medical Sciences, Jinan, China.

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http://doi.wiley.com/10.1002/cam4.1865
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http://dx.doi.org/10.1002/cam4.1865DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6308070PMC
December 2018

Delivery of CRISPR-Cas9 into Mouse Zygotes by Electroporation.

Methods Mol Biol 2019 ;1874:179-190

State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.

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http://link.springer.com/10.1007/978-1-4939-8831-0_10
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http://dx.doi.org/10.1007/978-1-4939-8831-0_10DOI Listing
June 2019

Editing porcine IGF2 regulatory element improved meat production in Chinese Bama pigs.

Cell Mol Life Sci 2018 Dec 26;75(24):4619-4628. Epub 2018 Sep 26.

State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China.

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http://link.springer.com/10.1007/s00018-018-2917-6
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http://dx.doi.org/10.1007/s00018-018-2917-6DOI Listing
December 2018

Extended pluripotent stem cells facilitate mouse model generation.

Protein Cell 2019 01;10(1):5-7

State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China.

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http://link.springer.com/10.1007/s13238-018-0573-0
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http://dx.doi.org/10.1007/s13238-018-0573-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321818PMC
January 2019

Bacteria-free minicircle DNA system to generate integration-free CAR-T cells.

J Med Genet 2019 01 20;56(1):10-17. Epub 2018 Jul 20.

State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, The Chinese Academy of Sciences, Beijing, China.

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http://dx.doi.org/10.1136/jmedgenet-2018-105405DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327863PMC
January 2019

5' capped and 3' polyA-tailed sgRNAs enhance the efficiency of CRISPR-Cas9 system.

Protein Cell 2019 03;10(3):223-228

State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China.

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http://dx.doi.org/10.1007/s13238-018-0552-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338620PMC
March 2019

Endogenous authentic OCT4A proteins directly regulate FOS/AP-1 transcription in somatic cancer cells.

Cell Death Dis 2018 05 22;9(6):585. Epub 2018 May 22.

State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, 310003, China.

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http://dx.doi.org/10.1038/s41419-018-0606-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5964179PMC
May 2018

Gene editing in T cell therapy.

J Genet Genomics 2017 Sep 28;44(9):415-422. Epub 2017 Sep 28.

State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100190, China; University of Chinese Academy of Sciences, Beijing 100049, China. Electronic address:

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http://dx.doi.org/10.1016/j.jgg.2017.09.002DOI Listing
September 2017

Hyperosmolarity evokes histamine release from ileum mucosa by stimulating a cholinergic pathway.

Biochem Biophys Res Commun 2017 11 19;493(2):1037-1042. Epub 2017 Sep 19.

Department of Thoracic Surgery, Shandong Cancer Hospital and Institute, Shandong Academy of Medical Sciences, Jinan, China. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2017.09.093DOI Listing
November 2017

CRISPR-Cas9 mediated LAG-3 disruption in CAR-T cells.

Front Med 2017 Dec 17;11(4):554-562. Epub 2017 Jun 17.

State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100190, China.

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http://dx.doi.org/10.1007/s11684-017-0543-6DOI Listing
December 2017

Editing base in mouse model.

Authors:
Haoyi Wang

Protein Cell 2017 08;8(8):558-559

State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China.

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http://dx.doi.org/10.1007/s13238-017-0432-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5546935PMC
August 2017

Generating Mouse Models Using Zygote Electroporation of Nucleases (ZEN) Technology with High Efficiency and Throughput.

Methods Mol Biol 2017 ;1605:219-230

The Jackson Laboratory, Bar Harbor, ME, 04609, USA.

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http://dx.doi.org/10.1007/978-1-4939-6988-3_15DOI Listing
February 2018

Temperature effect on CRISPR-Cas9 mediated genome editing.

J Genet Genomics 2017 04 30;44(4):199-205. Epub 2017 Mar 30.

State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China; University of Chinese Academy of Sciences, Beijing 100049, China. Electronic address:

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http://dx.doi.org/10.1016/j.jgg.2017.03.004DOI Listing
April 2017

CRISPR-Cas9-mediated multiplex gene editing in CAR-T cells.

Cell Res 2017 01 2;27(1):154-157. Epub 2016 Dec 2.

State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, The Chinese Academy of Sciences, Beijing, China.

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http://dx.doi.org/10.1038/cr.2016.142DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5223227PMC
January 2017

Molecular Criteria for Defining the Naive Human Pluripotent State.

Cell Stem Cell 2016 10 14;19(4):502-515. Epub 2016 Jul 14.

Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2016.06.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5065525PMC
October 2016

Delivery of Cas9 Protein into Mouse Zygotes through a Series of Electroporation Dramatically Increases the Efficiency of Model Creation.

J Genet Genomics 2016 05 8;43(5):319-27. Epub 2016 Mar 8.

The Jackson Laboratory, Bar Harbor, ME 04609, USA; State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China. Electronic address:

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http://dx.doi.org/10.1016/j.jgg.2016.02.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4892940PMC
May 2016

Oxytocin evokes a pulsatile PGE2 release from ileum mucosa and is required for repair of intestinal epithelium after injury.

Sci Rep 2015 Jul 10;5:11731. Epub 2015 Jul 10.

Department of Physiology, School of Medicine, Shandong University, Jinan, 250012, People's Republic of China.

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http://dx.doi.org/10.1038/srep11731DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4498177PMC
July 2015

CRISPR-Cas9-mediated genome editing and guide RNA design.

Mamm Genome 2015 Oct 20;26(9-10):501-10. Epub 2015 May 20.

The Jackson Laboratory, 600 Main Street, Bar Harbor, ME, 04609-1500, USA.

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http://dx.doi.org/10.1007/s00335-015-9565-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4602062PMC
October 2015

Targeting hepatitis B virus cccDNA by CRISPR/Cas9 nuclease efficiently inhibits viral replication.

Antiviral Res 2015 Jun 3;118:110-7. Epub 2015 Apr 3.

Jiangsu Key Laboratory of Infection and Immunity, Institutes of Biology and Medical Science, Soochow University, Suzhou 215123, China. Electronic address:

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http://dx.doi.org/10.1016/j.antiviral.2015.03.015DOI Listing
June 2015

Efficient CRISPR/Cas9-Mediated Genome Editing in Mice by Zygote Electroporation of Nuclease.

Genetics 2015 Jun 27;200(2):423-30. Epub 2015 Mar 27.

The Jackson Laboratory, Bar Harbor, Maine 04609 State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100090, China

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http://www.genetics.org/content/genetics/200/2/423.full.pdf
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http://www.genetics.org/cgi/doi/10.1534/genetics.115.176594
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http://dx.doi.org/10.1534/genetics.115.176594DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4492369PMC
June 2015

Generating genetically modified mice using CRISPR/Cas-mediated genome engineering.

Nat Protoc 2014 Aug 24;9(8):1956-68. Epub 2014 Jul 24.

1] Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, USA. [2] Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.

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http://dx.doi.org/10.1038/nprot.2014.134DOI Listing
August 2014

Genetic and chemical correction of cholesterol accumulation and impaired autophagy in hepatic and neural cells derived from Niemann-Pick Type C patient-specific iPS cells.

Stem Cell Reports 2014 Jun 15;2(6):866-80. Epub 2014 May 15.

Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA ; Skolkovo Institute of Science and Technology (Skoltech), Novaya Street 100, Skolkovo 143025, Moscow Region, Russia ; Department of Biology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02142, USA.

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http://dx.doi.org/10.1016/j.stemcr.2014.03.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4050353PMC
June 2014

Impaired autophagy in the lipid-storage disorder Niemann-Pick type C1 disease.

Cell Rep 2013 Dec 27;5(5):1302-15. Epub 2013 Nov 27.

Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, 9 Cambridge Center, Cambridge, MA 02142, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2013.10.042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3957429PMC
December 2013

One-step generation of mice carrying reporter and conditional alleles by CRISPR/Cas-mediated genome engineering.

Cell 2013 Sep 29;154(6):1370-9. Epub 2013 Aug 29.

Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.

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http://dx.doi.org/10.1016/j.cell.2013.08.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3961003PMC
September 2013

Multiplexed activation of endogenous genes by CRISPR-on, an RNA-guided transcriptional activator system.

Cell Res 2013 Oct 27;23(10):1163-71. Epub 2013 Aug 27.

1] Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA [2] Computational and Systems Biology Program, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1038/cr.2013.122DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3790238PMC
October 2013

Retrotransposon profiling of RNA polymerase III initiation sites.

Genome Res 2012 Apr 27;22(4):681-92. Epub 2012 Jan 27.

Department of Biological Chemistry, School of Medicine, University of California, Irvine, California 92697, USA.

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http://dx.doi.org/10.1101/gr.131219.111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3317150PMC
April 2012

"Calling cards" for DNA-binding proteins in mammalian cells.

Genetics 2012 Mar 3;190(3):941-9. Epub 2012 Jan 3.

Department of Genetics and Center for Genome Sciences and Systems Biology, Washington University, School of Medicine, St. Louis, Missouri 63108, USA.

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http://dx.doi.org/10.1534/genetics.111.137315DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3296256PMC
March 2012

Functional integration of dopaminergic neurons directly converted from mouse fibroblasts.

Cell Stem Cell 2011 Nov 20;9(5):413-9. Epub 2011 Oct 20.

Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.

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http://dx.doi.org/10.1016/j.stem.2011.09.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3210333PMC
November 2011

Calling Cards enable multiplexed identification of the genomic targets of DNA-binding proteins.

Genome Res 2011 May 6;21(5):748-55. Epub 2011 Apr 6.

Department of Genetics and Center for Genome Sciences and Systems Biology, Washington University, School of Medicine, St. Louis, Missouri 63108, USA.

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http://dx.doi.org/10.1101/gr.114850.110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3083092PMC
May 2011

'Calling Cards' method for high-throughput identification of targets of yeast DNA-binding proteins.

Nat Protoc 2008 ;3(10):1569-77

Department of Genetics, Washington University, School of Medicine, Genome Sequencing Center, St Louis, Missouri 63108, USA.

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http://dx.doi.org/10.1038/nprot.2008.148DOI Listing
December 2008

Evolution of the CYP2ABFGST gene cluster in rat, and a fine-scale comparison among rodent and primate species.

Genetica 2008 Jun 18;133(2):215-26. Epub 2007 Sep 18.

Department of Zoology, Miami University, Oxford, OH, 45056, USA.

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http://dx.doi.org/10.1007/s10709-007-9206-xDOI Listing
June 2008

Calling cards for DNA-binding proteins.

Genome Res 2007 Aug 10;17(8):1202-9. Epub 2007 Jul 10.

Department of Genetics, Washington University, School of Medicine, Genome Sequencing Center, St Louis, MO 63108, USA.

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http://dx.doi.org/10.1101/gr.6510207DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1933518PMC
August 2007

[Construction of Bifidobacterium Infantis/CD tumor targeting gene therapy system].

Zhongguo Fei Ai Za Zhi 2004 Apr;7(2):95-8

Department of Pathophysiology, West China Center of Medical Sciences of Sichuan University, Chengdu, Sichuan 610041, P.R.China.

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http://dx.doi.org/10.3779/j.issn.1009-3419.2004.02.04DOI Listing
April 2004

Organization and evolution of the Cyp2 gene cluster on mouse chromosome 7, and comparison with the syntenic human cluster.

Environ Health Perspect 2003 Nov;111(15):1835-42

Department of Zoology, Miami University, 700 East High Street, Oxford, OH 45056, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1241748PMC
http://dx.doi.org/10.1289/ehp.6546DOI Listing
November 2003