Publications by authors named "Hao Wang"

6,148 Publications

  • Page 1 of 1

Adsorption of microplastics on aquifer media: Effects of the action time, initial concentration, ionic strength, ionic types and dissolved organic matter.

Environ Pollut 2022 May 23:119482. Epub 2022 May 23.

State Key Laboratory of Simulation and Regulation of Water Cycle in River Basin, Beijing, 100038, China; China Institute of Water Resources and Hydropower Research, Beijing, 100038, China.

The adsorption of microplastic (MPs) on aquifer media is affected by their own properties and environmental factors. Research results have shown that the adsorption capacity of MPs on the three media has the following order: fine sand > medium sand > coarse sand, and the adsorption equilibrium times are 8 h, 12 h and 24 h, respectively. The adsorption process has three stages (fast linear distribution, slow adsorption and equilibrium stability), and the action law is compounded by the pseudo-second-order kinetic equation. After adsorption, MPs were observed on the three media, and there were single existence and aggregation phenomena. The energy spectrum analysis indicates that elemental carbon (C) appears on the surface of the medium after the action occurs, and the surface of the media adsorbs MPs to varying degrees. According to the results of infrared spectroscopy, after action, the peak areas of the absorption peaks at 680-880 cm and 1450-1620 cm increase. The absorption peaks are mainly C-H out-of-plane bending vibrations from aromatic hydrocarbons and C-H stretching vibrations on the benzene ring skeleton. As the initial concentration increases, the equilibrium adsorption capacity increases linearly. The isothermal adsorption of MPs in porous media conforms to the Freundlich model. The adsorption process is also affected by different anions and cations. The higher the ionic strength of NH is, the weaker the electrostatic effect of negatively charged MPs, thereby increasing the adsorption capacity of microplastics on porous media. Ca can promote the adsorption of MPs by the media through the formation of ternary complexes between cations, MPs and surface functional groups. The increase in SO and HCO concentrations gradually inhibits the adsorption of MPs.
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http://dx.doi.org/10.1016/j.envpol.2022.119482DOI Listing
May 2022

Correction: Strongly emissive white-light-emitting silver iodide based inorganic-organic hybrid structures with comparable quantum efficiency to commercial phosphors.

Chem Commun (Camb) 2022 May 26. Epub 2022 May 26.

Hoffmann Institute of Advanced Materials, Shenzhen Polytechnic, 7098 Liuxian Blvd, Nanshan District, Shenzhen, 518055, China.

Correction for 'Strongly emissive white-light-emitting silver iodide based inorganic-organic hybrid structures with comparable quantum efficiency to commercial phosphors' by Fang Lin , , 2020, , 1481-1484, DOI: https://doi.org/10.1039/C9CC09260A.
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http://dx.doi.org/10.1039/d2cc90193eDOI Listing
May 2022

Short-term effects of modest salt reduction combined with DASH diet on changing salt eating habits in hypertensive patients with type II diabetes.

Clin Exp Hypertens 2022 May 25:1-9. Epub 2022 May 25.

Health Management Center of the Second Affiliated Hospital, Chongqing Medical University, Chongqing, SC, China.

Objective: Excessive salt intake is currently the foremost universal risk factor for controllable chronic disease. This study evaluated the short-term effects of a modest salt intake reduction combined with the Chinese Modified Dietary Approaches to Stop Hypertension (CM-DASH) diet on sodium and potassium intake, mean arterial pressure (MAP), and pulse pressure (PP) in hypertensive patients with type II diabetes.

Methods: Sixty-one participants were randomized to the intervention group (52% low-sodium salt and DASH) and control group (normal salt and DASH). An 8-week dietary intervention was applied. Daily salt intake, blood pressure (BP), and drug use were recorded every week. Twenty-four-hour urine, casual urine, and blood samples were measured at baseline, the 4th week, and the end of the intervention.

Results: Fifty-nine patients (25 men) completed the entire study. Sodium intake decreased by 1259.66 (792.76, 1726.56)/705.80 (149.21, 1262.39) mg/day after 4 weeks (intervention: P < .001; control: P = .015). Potassium intake increased by 641.14 (73.31, 1208.96)/43.43 (-259.66, 346.53) mg/day (intervention: = .028); MAP decreased by 9.06 (6.69, 11.43)/7.16 (4.03, 10.28) mmHg (both: P < .001); PP decreased by 7.97 (3.05, 12.88)/5.74 (2.55,8.94) mmHg (intervention: P = .002; control: P = .001) after 8 weeks. However, the difference between the two groups was not statistically significant.

Conclusion: Modest salt reduction and the CM-DASH diet for hypertensive patients with type II diabetes can achieve short-term salt reduction effects. The effect on changing salt-eating habits needs to be investigated with an extended follow-up.
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http://dx.doi.org/10.1080/10641963.2022.2079666DOI Listing
May 2022

Echocardiography in the diagnosis of Shone's complex and analysis of the causes for missed diagnosis and misdiagnosis.

World J Clin Cases 2022 Apr;10(11):3369-3378

Department of Cardiovascular Surgery, Fuwai Hospital, Beijing 100037, China.

Background: Shone's complex is a rare syndrome characterized by congenital left heart defects that can differ among the patients.

Aim: To use echocardiography in the diagnosis of Shone's complex and analyze the causes of missed diagnosis and misdiagnosis.

Methods: This was a retrospective study of patients who underwent echocardiography and repair surgery from February 14, 2008, to November 22, 2019. The patients were followed once a year at the outpatient clinic after surgery.

Results: Sixty-six patients were included. The patients were 2.7 (0.8-5.6) years of age, and 54.5% were male. Ten (15.2%) had a history of heart surgery. The most common heart defect was the Annulo-Leaflet mitral ring (ALMR) (50/66, 75.8%), followed by coarctation of the aorta (CoA) (43/66, 65.2%). The patients had a variety of combinations of defects. Only two (3.0%) patients had all four defects. None of the patients had a family history of congenital heart disease. The preoperative echocardiographic findings were examined against the intraoperative findings. Echocardiography missed an ALMR in 31 patients (47.0%), a parachute mitral valve (PMV) in one patient (1.5%), subaortic stenosis in one patient (1.5%), and CoA in two patients (3.0%).

Conclusion: Echocardiography is an effective method to diagnose the Shone's complex. Due to this disease's complexity and interindividual variability, Improving the understanding of the disease can reduce misdiagnosis and missed diagnosis.
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http://dx.doi.org/10.12998/wjcc.v10.i11.3369DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9048561PMC
April 2022

Fudosteine attenuates acute lung injury in septic mice by inhibiting pyroptosis via the TXNIP/NLRP3/GSDMD pathway.

Eur J Pharmacol 2022 May 21:175047. Epub 2022 May 21.

Division of Pulmonary Diseases, State Key Laboratory of Biotherapy, and Department of Respiratory and Critical Care Medicine, West China Hospital of Sichuan University, Chengdu, China. Electronic address:

There is a dearth of effective pharmacotherapies for sepsis-induced acute lung injury/acute respiratory distress syndrome (ALI/ARDS) to which oxidative stress and excessive inflammation are major contributors. We hypothesized that fudosteine, a cysteine derivative, may protect against sepsis-induced ALI/ARDS given its anti-oxidant capacities. This study aimed to investigate the effects and mechanisms of fudosteine in a mouse model of sepsis-induced ALI. Sepsis was induced by cecal ligation and puncture (CLP). The intragastrical administration of fudosteine (25 mg/kg, 50 mg/kg, and 100 mg/kg) dose-dependently decreased proinflammatory cytokine levels in bronchoalveolar lavage fluid (BALF) and serum and reduced BALF/serum albumin and lung wet/dry weight ratios in septic mice. The lung injury score was significantly lowered by fudosteine [e.g., 0.18 ± 0.03 (100 mg/kg) vs. 0.42 ± 0.03 (CLP), P < 0.0001]. Fudosteine also reduced the biomarkers of lung epithelial injury in BALF and markedly improved oxidative stress indicators in lung tissues [e.g., malondialdehyde: 337.70 ± 23.78 (100 mg/kg) vs. 686.40 ± 28.36 (CLP) nmol/mg protein, P < 0.0001]. Lung tissue transcriptomics analyses revealed suppressed inflammatory responses and oxidative stress with fudosteine and the involvement of the inflammasome and pyroptosis pathways. Western blot analyses indicated that fudosteine inhibited the sepsis-induced activation of gasdermin D (GSDMD) and caspase-1 and the upregulation of thioredoxin-interacting protein (TXNIP), nucleotide-binding domain, leucine-rich repeat-containing receptor, pyrin domain-containing-3 (NLRP3), and apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC). Fudosteine therefore protects against sepsis-induced ALI in mice, and the inhibition of pyroptosis via the TXNIP/NLRP3/GSDMD pathway may be an underlying mechanism.
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http://dx.doi.org/10.1016/j.ejphar.2022.175047DOI Listing
May 2022

Prediction of Urban Street Public Space Art Design Indicators Based on Deep Convolutional Neural Network.

Comput Intell Neurosci 2022 11;2022:5508623. Epub 2022 May 11.

School of Landscape Architecture, Nanjing Forestry University, Nanjing, Jiangsu 210037, China.

This paper analyzes and studies the structure and parameters of the VGGNet network model and selects the most commonly used and efficient VGG-16 as the prototype of the improved model. A multiscale sampling layer is added at the end of the VGG-16 convolution part so that the model can input images of any size for training and testing while reducing the number of neurons in the fully connected layer. This improves the training speed of the model under the premise of ensuring the accuracy. This paper uses multisource street spatial data combined with geographic information spatial analysis technology to measure and evaluate the spatial quality of streets in the main urban area. From the three dimensions of vitality, safety, and greenness of urban street space quality, a systematic structure for evaluation and analysis of street space quality is constructed. Street vitality includes eight index factors: entrance and exit density, street furniture density, street sketch density, street characteristic landscape density, POI density, POI diversity, commercial POI ratio, and street population density. There are five index factors: degree, roadside parking occupancy ratio, traffic signal system density, sidewalk width proportion, and street facility density. We use ArcGIS to build an index factor information database for statistical analysis and visualization. According to the natural discontinuous point classification method, the safety level of urban street public space is divided into five grades. The sample size of the first four grades has a small fluctuation range. The sample sizes are 153, 172, 153, and 158, respectively, accounting for 21%, 23%, 21%, and 21% of the total street samples, of which the first two grades occupy a total of 44%, so 44% of the streets in the main urban area have a low-quality level of street space. Level 5 has a sample of 102 streets, accounting for 14%, with an average street space quality value of 0.43.
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http://dx.doi.org/10.1155/2022/5508623DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9117065PMC
May 2022

Ursolic Acid Ameliorates Spinal Cord Injury in Mice by Regulating Gut Microbiota and Metabolic Changes.

Front Cell Neurosci 2022 4;16:872935. Epub 2022 May 4.

Orthopaedic Institute, Huizhou Municipal Central Hospital, Huizhou, China.

: Spinal cord injury (SCI) damages the autonomic nervous system and affects the homeostasis of gut microbiota. Ursolic acid (UA) is a candidate drug for treating nervous system injury due to its neuroprotective and antioxidant functions. The purpose of our study was to investigate the role of UA on SCI and its mechanism. : UA was administered to SCI mice and the solvent corn oil was used as control. The weight of the mice was recorded daily. Mice feces were collected 21 days after surgery for 16S rRNA-amplicon sequencing and untargeted metabolomics analysis. The expressions of NF-κB, IL-1β, and TNF-α in the spinal cord and colon tissues of mice were detected by Western blot and Enzyme-linked immunosorbent assay, respectively. Immunohistochemistry was used to analyze the expression of NeuN, NF-200, and synapsin in the spinal cord tissues. : UA treatment increased body weight and soleus muscle weight of SCI mice. UA treatment inhibited inflammatory response and protected neuronal activity in SCI mice. UA improved the relative abundance of Muribaculaceae, Lachnospiraceae_NK4A136_group, and Alloprevotell genus in the gut tract of SCI mice. SCI destroyed the Glutamine_and_D-glutamate_metabolism, Nitrogen_metabolism, Aminoacyl-tRNA_biosynthesis, and Taurine_and_hypotaurine_metabolism in the gut of mice, which might be alleviated by UA. : UA treatment could inhibit SCI progression by improving the gut environment and metabolic changes, promoting synaptic regeneration and anti-inflammatory effects.
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http://dx.doi.org/10.3389/fncel.2022.872935DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9115468PMC
May 2022

Exploration of the Shared Gene and Molecular Mechanisms Between Endometriosis and Recurrent Pregnancy Loss.

Front Vet Sci 2022 6;9:867405. Epub 2022 May 6.

Department of Obstetrics and Gynecology, Shenzhen University General Hospital, Shenzhen, China.

Endometriosis (EMs) is a common benign gynecological disease in women of childbearing age, which usually causes pelvic pain, secondary dysmenorrhea, and infertility. EMs has been linked to recurrent pregnancy loss (RPL) in epidemiological data. The relationship of both, however, remains unknown. The purpose of this study is to explore the underlying pathological mechanisms between EMs and RPL. We searched Gene Expression Omnibus (GEO) database to obtain omics data of EMs and RPL. Co-expression modules for EMs and RPL were investigated by using weighted gene co-expression network analysis (WGCNA). The intersections of gene modules with the strong correlation to EMs or RPL obtained by WGCNA analysis were considered as shared genes. MicroRNAs (miRNAs) and their corresponding target genes linked to EMs and RPL were found though the Human MicroRNA Disease Database (HMDD) and the miRTarbase database. Finally, we constructed miRNAs-mRNAs regulatory networks associated with the two disorders by using the intersection of previously obtained target genes and shared genes. We discovered as significant modules for EMs and RPL, respectively, by WGCNA. The energy metabolism might be the common pathogenic mechanism of EMs and RPL, according to the findings of a Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis. We discovered several target genes that might be linked to these two disorders, as well as the potential mechanisms. RAB8B, GNAQ, H2AFZ, SUGT1, and LEO1 could be therapeutic candidates for RPL and EMs. The PI3K-Akt signaling pathway and platelet activation were potentially involved in the mechanisms of EM-induced RPL. Our findings for the first time revealed the underlying pathological mechanisms of EM-induced RPL and identified several useful biomarkers and potential therapeutic targets.
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http://dx.doi.org/10.3389/fvets.2022.867405DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9120926PMC
May 2022

Targeting the human β receptor inhibits inflammatory myeloid cells and lung injury caused by acute cigarette smoke exposure.

Respirology 2022 May 22. Epub 2022 May 22.

School of Health & Biomedical Sciences, RMIT University, Bundoora, Victoria.

Background And Objective: Chronic obstructive pulmonary disease (COPD) is a devastating disease commonly caused by cigarette smoke (CS) exposure that drives tissue injury by persistently recruiting myeloid cells into the lungs. A significant portion of COPD patients also present with overlapping asthma pathology including eosinophilic inflammation. The β cytokine family includes granulocyte monocyte-colony-stimulating factor, IL-5 and IL-3 that signal through their common receptor subunit β to promote the expansion and survival of multiple myeloid cells including monocytes/macrophages, neutrophils and eosinophils.

Methods: We have used our unique human β receptor transgenic (hβ Tg) mouse strain that expresses human β instead of mouse β and β in an acute CS exposure model. Lung tissue injury was assessed by histology and measurement of albumin and lactate dehydrogenase levels in the bronchoalveolar lavage (BAL) fluid. Transgenic mice were treated with an antibody (CSL311) that inhibits human β signalling.

Results: hβ Tg mice responded to acute CS exposure by expanding blood myeloid cell numbers and recruiting monocyte-derived macrophages (cluster of differentiation 11b [CD11b ] interstitial and exudative macrophages [IM and ExM]), neutrophils and eosinophils into the lungs. This inflammatory response was associated with lung tissue injury and oedema. Importantly, CSL311 treatment in CS-exposed mice markedly reduced myeloid cell numbers in the blood and BAL compartment. Furthermore, CSL311 significantly reduced lung CD11b IM and ExM, neutrophils and eosinophils, and this decline was associated with a significant reduction in matrix metalloproteinase-12 (MMP-12) and IL-17A expression, tissue injury and oedema.

Conclusion: This study identifies CSL311 as a therapeutic antibody that potently inhibits immunopathology and lung injury caused by acute CS exposure.
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http://dx.doi.org/10.1111/resp.14297DOI Listing
May 2022

Deep learning-based multimodal image analysis for cervical cancer detection.

Methods 2022 May 19. Epub 2022 May 19.

Department of Orthopedic Surgery, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, 100730, China; State Key Laboratory of Complex Severe and Rare Diseases, Beijing, 100730, China; Beijing Key Laboratory for Genetic Research of Skeletal Deformity, Beijing, 100730, China; Key laboratory of big data for spinal deformities, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, 100730, China.

Cervical cancer is the fourth most common cancer in women, and its precise detection plays a critical role in disease treatment and prognosis prediction. Fluorodeoxyglucose positron emission tomography and computed tomography, i.e., FDG-PET/CT and PET/CT, have established roles with superior sensitivity and specificity in most cancer imaging applications. However, a typical FDG-PET/CT analysis involves the time-consuming process of interpreting hundreds of images, and the intense image screening work has greatly hindered clinicians. We propose a computer-aided deep learning-based framework to detect cervical cancer using multimodal medical images to increase the efficiency of clinical diagnosis. This framework has three components: image registration, multimodal image fusion, and lesion object detection. Compared to traditional approaches, our adaptive image fusion method fuses multimodal medical images. We discuss the performance of deep learning in each modality, and we conduct extensive experiments to compare the performance of different image fusion methods with some state-of-the-art (SOTA) object-detection deep learning-based methods in images with different modalities. Compared with PET, which has the highest recognition accuracy in single-modality images, the recognition accuracy of our proposed method on multiple object detection models is improved by an average of 6.06%. And compared with the best results of other multimodal fusion methods, our results have an average improvement of 8.9%.
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http://dx.doi.org/10.1016/j.ymeth.2022.05.004DOI Listing
May 2022

Progress of flexible strain sensors for physiological signal monitoring.

Biosens Bioelectron 2022 Apr 23;211:114298. Epub 2022 Apr 23.

The First Affiliated Hospital of Sun Yat-Sen University, School of Electronics and Information Technology, State Key Laboratory of Optoelectronic Materials and Technologies, Sun Yat-Sen University, Guangzhou, 510006, China. Electronic address:

Flexible strain sensors, as a key component of the cutting-edge wearable and implantable electronics, have facilitated applications pertaining to human health monitoring and diagnosis. To fulfill the increasing requirements of sensing performance and broadening the application scope, novel materials and device design strategies have been continuously developed over the past decade. Herein, the recent progresses of flexible strain sensors developed for monitoring the physiological signals are selectively reviewed, from the perspective of the possible correlation between the device microstructure and their corresponding applications. Firstly, representative strain sensors developed based on four fundamental working mechanisms: piezoresistance, capacitance, piezoelectricity and triboelectricity are respectively introduced, subclassified by the type of active material or the similarity in microstructure. Next, a number of biomedical applications of flexible strain sensors are highlighted, including the detections of different types of physiological signals using specific microstructured strain sensors. Lastly, the role of the transduction mechanism and the device microstructure in the sensing characteristic are comprehensively discussed, and prospective forms of flexible strain sensors to meet the existing and future challenges in wearable/implantable electronics are summarized.
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http://dx.doi.org/10.1016/j.bios.2022.114298DOI Listing
April 2022

[Prenatal utility of parental source verification on the interpretation of copy number variation identified by chromosomal microarray analysis].

Authors:
Yang Yang Hao Wang

Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2022 May;39(5):542-545

Prenatal Diagnosis Center, Hangzhou Maternity and Child Care Hospital, Hangzhou, Zhejiang 310000, China.

Objective: To investigate the parental-origin verification of fetal CNVs in the setting of prenatal diagnosis.

Methods: 182 families were recruited in this study. All the pregnant women underwent transabdominal amniocentesis or cordocentesis, and the amniotic fluid or cord blood samples were then subjected to karyotyping and chromosomal microarray analysis (CMA) respectively. The peripheral blood specimens of fetal parents were also tested by CMA for determining the parental-origin of fetal CNVs. Then we followed up the clinical outcomes of the fetuses.

Results: Of the 182 fetuses, 163 (89.6%) had parental-origin CNVs, and 19 (10.4%) had de novo CNVs. 149 (91.4%) of the parental-origin CNVs were classified into the variant of uncertain significance (VUS) before parental-origin tests. After parental source verification, 137 (91.9%) of these VUS cases were changed into likely benign cases. Among the 163 cases of parental-origin CNVs, 122 (74.8%) fetuses were born healthy. Among the 19 de novo cases, 9 of these families chose to terminate the pregnancy.

Conclusion: The majority of inherited CNVs detected by CMA had a tendency to be benign, and the parental source verification could assist the elucidation of clinical significance of CNVs in prenatal diagnosis.
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http://dx.doi.org/10.3760/cma.j.cn511374-20210122-00066DOI Listing
May 2022

Mercury stress tolerance in wheat and maize is achieved by lignin accumulation controlled by nitric oxide.

Environ Pollut 2022 May 18;307:119488. Epub 2022 May 18.

National Key Laboratory of Wheat and Maize Crop Science, Key Laboratory of Regulating and Controlling Crop Growth and Development Ministry of Education, Henan Agricultural University, Zhengzhou, Henan, 450046, China. Electronic address:

Nitric oxide (NO) is an important phytohormone for plant adaptation to mercury (Hg) stress. The effect of Hg on lignin synthesis, NO production in leaf, sheath and root and their relationship were investigated in two members of the grass family - wheat and maize. Hg stress decreased growth and lignin contents, significantly affected phenylpropanoid and monolignol pathways (PAL, phenylalanine ammonia-lyase; 4-coumarate: CoA ligase, 4CL; cinnamyl alcohol dehydrogenase, CAD), with maize identified to be more sensitive to Hg stress than wheat. Among the tissue types, sheath encountered severe damage compared to leaves and roots. Hg translocation in maize was about twice that in wheat. Interestingly, total NO produced under Hg stress was significantly decreased compared to control, with maximum reduction of 43.4% and 42.9% in wheat and maize sheath, respectively. Regression analysis between lignin and NO contents or the activities of three enzymes including CAD, 4CL and PAL displayed the importance of NO contents, CAD, 4CL and PAL for lignin synthesis. Further, the gene expression profiles encoding CAD, 4CL and PAL provided support for the damaging effect of Hg on wheat sheath, and maize shoot. To validate NO potential to mitigate Hg toxicity in maize and wheat, NO donor and NO synthase inhibitor were supplemented along with Hg. The resulting phenotype, histochemical analysis and lignin contents showed that NO mitigated Hg toxicity by improving growth and lignin synthesis and accumulation. In summary, Hg sensitivity was higher in maize seedlings compared to wheat, which was associated with the lower lignin contents and reduced NO contents. External supplementation of NO is proposed as a sustainable approach to mitigate Hg toxicity in maize and wheat.
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http://dx.doi.org/10.1016/j.envpol.2022.119488DOI Listing
May 2022

Highly efficient Cd(Ⅱ) removal using 3D N-doped carbon derived from MOFs: Performance and mechanisms.

J Hazard Mater 2022 May 13;436:129149. Epub 2022 May 13.

National Engineering Laboratory for Advanced Municipal Wastewater Treatment and Reuse Technology, Engineering Research Center of Beijing, Beijing University of Technology, Beijing 100124, PR China. Electronic address:

Cadmium (Cd) removal is imperative to ensure the safety of aquatic-ecosystem, yet its effective removal technology has remained elusive by far. To address this concern, three-dimensional N-doped carbon (NC) polyhedrons affording ample porosity is fabricated based upon the thermal carbonization and KOH activation of zeolitic imidazolate framework-8 (ZIF-8) precursor. Thus-derived activated NC (a-NC) adsorbent not only overcomes the inherent instability of ZIF-8 but also harvests a maximum Cd(Ⅱ) adsorption capacity of 370.2 mg g, which evidently surpasses those of bare NC counterpart as well as previously reported adsorbents. Impressively, a-NC achieves ca. 100% removal of aqueous Cd(Ⅱ) in a broad working pH range (5-9), and particularly attains stable performances (81-92%) in various realistic water. Theoretical calculations in combination with experimental characterizations further offer mechanistic insight into the enhanced removal exerted by a-NC. Notably, owing to the increased specific surface area (3041 vs. 389 m g) and enhanced sp carbon content (91.7 vs. 68.8%) of a-NC as compared to NC, advanced Cd(Ⅱ) adsorption via a-NC can be exhibited. Our designed a-NC material harnessing favorable recycling capability would be in particular attractive in the realm of practical Cd(Ⅱ) remediation.
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http://dx.doi.org/10.1016/j.jhazmat.2022.129149DOI Listing
May 2022

Exposure to indoor air pollution from solid fuel and its effect on depression: a systematic review and meta-analysis.

Environ Sci Pollut Res Int 2022 May 20. Epub 2022 May 20.

Department of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University, No. 81 Meishan Road, Hefei, 230032, Anhui, People's Republic of China.

A growing body of research has investigated the relationship between indoor air pollution from solid fuel and depression risk. Our study aimed to elucidate the relationship between indoor air pollution from solid fuel and depression in observational studies. The effect of indoor air pollution on depression was estimated using pooled odds ratios (ORs) with 95% confidence intervals (CIs). Heterogeneity was evaluated by the I-squared value (I), and the random-effects model was adopted as the summary method. We finalized nine articles with 70,214 subjects. The results showed a statistically positive relationship between the use of household solid fuel and depression (OR = 1.22, 95% CI = 1.09-1.36). Subgroup analysis based on fuel type groups demonstrated that indoor air pollution from solid fuel was a higher risk to depression (OR = 1.24, 95% CI = 1. 10-1.39; I = 67.0%) than that from biomass (OR = 1.18, 95% CI = 0.96-1.45; I = 66.5%). In terms of fuel use, the use of solid fuel for cooking and heating increased depression risk, and the pooled ORs were 1.21 (95% CI = 1.08-1.36) and 1.23 (95% CI = 1.13-1.34). Exposure to indoor air pollution from solid fuel might increase depression risk.
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http://dx.doi.org/10.1007/s11356-022-20841-7DOI Listing
May 2022

Tumor-associated macrophages regulate the function of cytotoxic T lymphocyte through PD-1/PD-L1 pathway in multiple myeloma.

Cancer Med 2022 May 20. Epub 2022 May 20.

Department of Hematology, Tianjin Medical University General Hospital, Tianjin, People's Republic of China.

Background: Tumor-associated macrophages (TAMs) are originated from circulating mononuclear cells in peripheral blood. They result from the recruitment of tumor cells and are a vital constituent of the tumor microenvironment. TAMs may be involved in the immunological escape of vicious clonal plasma cells (PC) in the bone marrow (BM) of sufferers with myeloma.

Methods: From March 2020 to January 2021, 28 healthy controls (HC) and 86 multiple myeloma (MM) (53 newly diagnosed MM [NDMM] and 33 remissions) patients were enrolled as objects of the study. The expression of TAMs in the BM, CSF1 on CD138 + cells, and CSF1R on macrophages were detected by the method of flow cytometry, and the expression of PD-1 on CD8 + T cells and PD-L1 on TAMs were also done. Bone marrow mononuclear cells (BMMNCs) were extracted and cultured into TAMs, CD8 + T cells were sorted by magnetic beads and cultured, a coculture system was established and different inhibitors were added. The expression of the perforin and granzyme B was detected by flow cytometry.

Results: The percentage of TAMs in NDMM group (61.49 ± 2.176%) increased when compared with remission (23.08 ± 1.699%, p < 0.001) and HC group (17.95 ± 1.865%, p < 0.001), and TAMs decreased after adding CSF1R inhibitor. Moreover, the expression of CSF1 on CD138 + cells increased significantly in NDMM group (17.090 ± 0.9156%) than remission (8.214 ± 0.5911% p < 0.001), and HC group (5.257 ± 0.6231%, p < 0.001), and CSF1R on macrophages increased significantly in NDMM group (58.78 ± 2.286%) than remission (20.74 ± 1.376%, p < 0.001) and HC group (17.42 ± 1.081%, p < 0.001). The expression of PD-1 on CD8 + T cells in NDMM group (32.64 ± 2.982%) increased than remission (20.35 ± 2.335% p < 0.01) and HC group (17.53 ± 1.349%, p < 0.001), and PD-L1 on TAMs also increased in NDMM group (50.92 ± 2.554%) than remission (20.02 ± 1.893%, p < 0.001) and HC group (13.08 ± 1.289%, p < 0.001). When CD8 + T cells were cocultured with TAMs, the perforin and granzyme B levels decreased significantly. However, the perforin and granzyme B levels were partly restored after adding CSF1R inhibitor and anti-PD-L1 antibody.

Conclusion: Our study shows that TAMs were increased in MM patients which can inhibit the function of cytotoxic T lymphocyte (CTL) through the PD-1/ PD-L1 signaling pathway and participate in the occurrence of immune escape of myeloma cells.
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http://dx.doi.org/10.1002/cam4.4814DOI Listing
May 2022

Loadings of lycopene in emulsion and sodium alginate-K-carrageenan composite systems: Preparation, characterization, bioaccessibility, and kinetics.

J Food Sci 2022 May 20. Epub 2022 May 20.

State Key Laboratory of Food Nutrition and Safety, Tianjin University of Science and Technology (TUST), Tianjin, China.

This research aims to prepare capsules emulsion using gallic acid (GA), dextran (DEX), bovine serum albumin (BSA), sodium alginate, and K-carrageenan (K-Car) as the biological delivery system of lycopene. The stability and bioaccessibility of lycopene were further improved through encapsulation of covalent complex of sodium alginate and K-Car. The molecular weight distribution and secondary structure of the conjugates were analyzed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) and Fourier transform infrared spectroscopy (FTIR). The storage stability of the emulsion stabilized by conjugates was measured with Turbiscan stability index (TSI) and fluctuation of the particle size. The TSI value of ternary conjugates was 18.7 (37℃) with particle sizes ranging from 208 to 319 nm. Then, the changes of three-dimensional reticulate structures and physical properties of sodium alginate-K were analyzed by scanning electron microscopy (SEM) and TPA. The thermal stability of the sodium alginate-K-Car composite systems was increased compared with sodium alginate. The bioaccessibility of lycopene was significantly improved under the dual embedding of BSA-DEX-GA conjugate emulsion and sodium alginate-K-Car composite systems.
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http://dx.doi.org/10.1111/1750-3841.16167DOI Listing
May 2022

IL-22 Protects against Biliary Ischemia-Reperfusion Injury after Liver Transplantation via Activating STAT3 and Reducing Apoptosis and Oxidative Stress Levels In Vitro and In Vivo.

Oxid Med Cell Longev 2022 10;2022:9635075. Epub 2022 May 10.

Department of Organ Transplantation, Tianjin First Central Hospital, School of Medicine, Nankai University, Tianjin 300192, China.

Biliary complications are currently one of the leading causes of liver failure and patient death after liver transplantation and need to be solved urgently. Biliary ischemia-reperfusion injury (IRI) is one of the important causes of biliary complications. IL-22 has a protective effect on liver injury and hepatitis diseases, and its safety and efficacy in the treatment of hepatitis have also been proved in human clinical experiments. Furthermore, multiple studies have confirmed that IL-22 promotes the proliferation and repair of epithelial cells in various organs. Still, its function in the bile duct after transplantation has not been explored. This study was aimed at investigating the effects of IL-22 on cholangiocyte IRI in vitro and in vivo and exploring its underlying mechanisms. We simulated the hypoxia process of bile duct epithelial cells through in vitro experiments to investigate the protective function and molecular mechanism of IL-22 on bile duct epithelial cells. Subsequently, the function and mechanism of IL-22 in the biliary IRI model of autologous orthotopic liver transplantation in rats were assessed. This study confirmed that IL-22 could promote cholangiocyte proliferation, decrease the apoptosis rate of cholangiocytes and tissues, decrease MDA levels, and increase SOD levels by activating STAT3. In addition, IL-22 can also reduce the level of mitochondrial membrane depolarization, protect mitochondria, reduce ROS production, and play a role in protecting bile ducts. These findings provide evidence for IL-22 as a novel and effective treatment for biliary IRI after liver transplantation.
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http://dx.doi.org/10.1155/2022/9635075DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9113870PMC
May 2022

Signifying the Relationship Between Psychological Factors and Turnover Intension: The Mediating Role of Work-Related Stress and Moderating Role of Job Satisfaction.

Front Psychol 2022 3;13:847948. Epub 2022 May 3.

School of Management, Shanghai University, Shanghai, China.

Human capital plays a significant role in an organization's advancement. In recent years, emerging work-related psychological issues have become a critical factor, demanding considerable attention from management. As such, this study measures the role of job satisfaction in work-related stress and employees' turnover intentions. There is a mediating relationship between work-related stress-such as emotional exhaustion, work engagement, role conflict, and psychosocial risks-and turnover intentions. The study used primary data collection techniques to gather data and purposive sampling to analyze the data. The study's sample size consisted of 270 employees working in Chinese organizations. SmartPLS software was used to test the research hypothesis. The study results show the mediating role of work-related stress and moderating role of employees' job satisfaction. Accordingly, the study provides implications for managers, encouraging them to take the necessary steps in controlling the turnover rate by enhancing employees' morale (i.e., job satisfaction) and work engagement.
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http://dx.doi.org/10.3389/fpsyg.2022.847948DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9110882PMC
May 2022

Prediction of Hardenability Curves for Non-Boron Steels via a Combined Machine Learning Model.

Materials (Basel) 2022 Apr 26;15(9). Epub 2022 Apr 26.

School of Materials Science and Engineering, University of Science and Technology Beijing, Beijing 100083, China.

Hardenability is one of the most basic criteria influencing the formulation of the heat treatment process and steel selection. Therefore, it is of great engineering value to calculate the hardenability curves rapidly and accurately without resorting to any laborious and costly experiments. However, generating a high-precision computational model for steels with different hardenability remains a challenge. In this study, a combined machine learning (CML) model including k-nearest neighbor and random forest is established to predict the hardenability curves of non-boron steels solely on the basis of chemical compositions: (i) random forest is first applied to classify steel into low- and high-hardenability steel; (ii) k-nearest neighbor and random forest models are then developed to predict the hardenability of low- and high-hardenability steel. Model validation is carried out by calculating and comparing the hardenability curves of five steels using different models. The results reveal that the CML model works well for its distinguished prediction performance with precise classification accuracy (100%), high correlation coefficient (≥0.981), and low mean absolute errors (≤3.6 HRC) and root-mean-square errors (≤3.9 HRC); it performs better than JMatPro and empirical formulas including the ideal critical diameter method and modified nonlinear equation. Therefore, this study demonstrates that the CML model combining material informatics and data-driven machine learning can rapidly and efficiently predict the hardenability curves of non-boron steel, with high prediction accuracy and a wide application range. It can guide process design and machine part selection, reducing the cost of trial and error and accelerating the development of new materials.
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http://dx.doi.org/10.3390/ma15093127DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9103254PMC
April 2022

A Novel Method for Detecting the Two-Degrees-of-Freedom Angular Displacement of a Spherical Pair, Based on a Capacitive Sensor.

Sensors (Basel) 2022 Apr 30;22(9). Epub 2022 Apr 30.

Key Laboratory of Airborne Optical Imaging and Measurement, Changchun Institute of Optics, Fine Mechanics and Physics, Chinese Academy of Sciences, Changchun 130033, China.

The spherical pair has an important role in the inner frame of the stabilization mechanism of the aviation optoelectronic pod. However, its two-degrees-of-freedom (2-DOF) angular displacement signal is difficult to detect, seriously restricting its application in aviation optoelectronic pods. Therefore, this study proposes a new method to measure a spherical pair's 2-DOF angular displacement using a spherical capacitive sensor. The capacitive sensor presented by this method realizes the measurement of the 2-DOF angular displacement of the spherical pair by integrating the spherical electrode groups in the ball head and the ball socket of the spherical pair. First, based on the geometric structure of the spherical pair, the structure of the capacitive sensor is designed, and the mathematical model for the capacitive sensor is deduced. Then, the sensor's output capacitance, in different directions, is simulated by Ansoft Maxwell software. Finally, an experiment device is built for the measurement experiments. The simulation analysis and experimental results show that the spherical capacitive sensor has an approximately linear output in different directions, and the measured output capacitance is as high as 89.7% of the theoretical value. Compared with the existing sensors that measure the 2-DOF angular displacement signal of the ball pair, the sensor proposed in this study has an integrated structure, which can be integrated into the spherical pair. That makes it possible to apply the spherical pair to the inner frame of the aviation optoelectronic pod.
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http://dx.doi.org/10.3390/s22093437DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9103906PMC
April 2022

Effect of the Porcine STC-1 Gene on Autophagy and Mitochondrial Function as Induced by Serum Starvation.

Biochem Genet 2022 May 19. Epub 2022 May 19.

College of Veterinary Medicine, Yangzhou University/Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonosis, Yangzhou, 225009, Jiangsu, People's Republic of China.

Stanniocalcin-1 (STC-1) is a glycoprotein hormone involved in calcium/phosphorus metabolism and direct inhibition of bone and muscle growth. The aim of this study was to investigate the STC-1 gene with respect to the regulatory mechanisms of porcine growth metabolic pathways involving autophagy. Western blotting was used to detect the expression of autophagy and mitochondrial function-related proteins, and flow cytometry was used to detect mitochondrial function-related. Changes in the autophagosome and mitochondrial were observed by electron microscopy. The expression of the autophagy-related proteins was detected by confocal microscopy. The results showed that Pink1, Parkin and LC3B expression was increased; SQSTM1/P62 expression was reduced. Electron microscopy revealed that the cells in the serum starvation group all produced autophagosomes. The fluorescence intensity of GFP-LC3B and GFP-Parkin increased. The Bax/Bcl-2 ratio, Pink1 and Parkin protein levels were profoundly reduced in the STC-KO. In addition, the increase in Mfn2, OPA1, DRP1 and LC3B proteins was attenuated; the increase in the apoptosis rate and amount of active oxygen was attenuated; the decrease in membrane potential; the decrease in ATP was reversed; the fluorescence intensity of GFP-LC3B and GFP-Parkin was increased. These results indicate that autophagy can be caused by serum starvation. Knocking out the porcine STC-1 gene had an obvious antiapoptotic effect on cells, the inhibition of serum starvation-induced autophagy. This is the first study to show that the porcine STC-1 gene confers self-protection in the absence of nutrients. To provide a theoretical basis for studying the effect of STC-1 on pig growth and development.
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http://dx.doi.org/10.1007/s10528-022-10233-4DOI Listing
May 2022

A cleaner biocementation method of soil via microbially induced struvite precipitation: A experimental and numerical analysis.

J Environ Manage 2022 May 16;316:115280. Epub 2022 May 16.

School of Civil Engineering, Dalian University of Technology, Dalian, 116024, China. Electronic address:

Microbial-induced struvite precipitation (MISP) is a new biocementation method for soil improvement and hydraulic permeability reduction. Compared with traditional microbial-induced carbonate precipitation (MICP), MISP can significantly reduce the production of harmful ammonium ions during biochemical reactions and convert ammonium ions into struvite with promising mechanical strength. In this study, a series of experiments were conducted to compare the performance of the MICP and the MISP processes on sandy soils. Results showed that the average content of calcium carbonate in MISP cemented sand columns after 3 times of injection is similar to that in MICP cemented sand columns after 9 times of injection. The hydraulic permeability of MISP cemented sand columns after 3 times of injection is an order of magnitude lower than that of MICP cemented sand columns after 9 times of injection. To further investigate the physicochemical interactions during MISP and MICP processes, a one-dimensional finite element code considering the chemical reactions and the solute transportation was proposed. Results show that most of the MISP were formed in the early 3 h of the 6 h injection cycle, whereas most of the MICP were formed in the last 5 h of the injection cycle. The simulated total mass of the MISP precipitation, 11.3 g, was close to the experimental result of 9.6 g. The spatial distribution of MISP is more uneven as compared to MICP, as a result of the much faster reaction rate of struvite than calcium carbonate. The findings suggested that MISP could partially replace MICP in the applications of leakage mitigation and reinforcement of sandy soils.
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http://dx.doi.org/10.1016/j.jenvman.2022.115280DOI Listing
May 2022

Architectural effects regulate resource allocation within the inflorescences with nonlinear blooming patterns.

Am J Bot 2022 May 19. Epub 2022 May 19.

Yunnan Key Laboratory of Plant Reproductive Adaptation and Evolutionary Ecology, Institute of Biodiversity, School of Ecology and Environmental Science, Yunnan University, Kunming, 650504, Yunnan, China.

Premise: Spatial and temporal resource allocations within inflorescences have been well-studied in many plants based on flowering sequence or floral position. However, there had been few attempts to investigate architectural effects and resource competition in species where the blooming pattern does not follow a linear positional pattern within the inflorescence. Moreover, most flowering plants show female-biased sex allocation in early or basal flowers, but it is unclear in species with inherent and changeless ovule production.

Methods: We investigated intra-inflorescence variation in reproductive traits of Salvia przewalskii, a perennial herb with 4-ouvle ovary flowers and flowering sequence-floral position decoupled inflorescences. To detect the effects of resource competition and architectural effects on reproductive success, we manipulated inflorescence (removal floral buds by position and flowering sequence) and pollination (opened and supplementary pollination).

Results: Pollen production and dry mass deceased from bottom to top flowers but didn't significantly differ following flowering sequence, resulting in male-biased sex allocation in basal flowers. The seed production, fruit set, bud developmental exhibited significant declining trends from proximal to distal positions regardless of the thinning and pollen treatments. Meanwhile, the seed production, fruit set, bud developmental success did not significant difference when thinning conducted according to flowering sequence.

Conclusions: Architectural effects plays a crucial role in resource allocation within decoupled flowering inflorescences. Moreover, our results highlighted that inherent floral traits, such as changeless ovule production, may modify architectural effects on sex allocation. This article is protected by copyright. All rights reserved.
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http://dx.doi.org/10.1002/ajb2.16001DOI Listing
May 2022

Colon Tumors in Enterotoxigenic Bacteroides fragilis (ETBF)-Colonized Mice Do Not Display a Unique Mutational Signature but Instead Possess Host-Dependent Alterations in the APC Gene.

Microbiol Spectr 2022 May 19:e0105522. Epub 2022 May 19.

Department of Medicine, Johns Hopkins University School of Medicinegrid.471401.7, Baltimore, Maryland, USA.

Enterotoxigenic Bacteroides fragilis (ETBF) is consistently found at higher frequency in individuals with sporadic and hereditary colorectal cancer (CRC) and induces tumorigenesis in several mouse models of CRC. However, whether specific mutations induced by ETBF lead to colon tumor formation has not been investigated. To determine if ETBF-induced mutations impact the gene, and other tumor suppressors or proto-oncogenes, we performed whole-exome sequencing and whole-genome sequencing on tumors isolated after ETBF and sham colonization of and VC mice, as well as whole-genome sequencing of organoids cocultured with ETBF. Our results indicate that ETBF-induced tumor formation results from loss of heterozygosity (LOH) of , unless the mismatch repair system is disrupted, in which case, tumor formation results from new acquisition of protein-truncating mutations in . In contrast to polyketide synthase-positive Escherichia coli (+ E. coli), ETBF does not produce a unique mutational signature; instead, ETBF-induced tumors arise from errors in DNA mismatch repair and homologous recombination DNA damage repair, established pathways of tumor formation in the colon, and the same genetic mechanism accounting for sham tumors in these mouse models. Our analysis informs how this procarcinogenic bacterium may promote tumor formation in individuals with inherited predispositions to CRC, such as Lynch syndrome or familial adenomatous polyposis (FAP). Many studies have shown that microbiome composition in both the mucosa and the stool differs in individuals with sporadic and hereditary colorectal cancer (CRC). Both human and mouse models have established a strong association between particular microbes and colon tumor induction. However, the genetic mechanisms underlying putative microbe-induced colon tumor formation are not well established. In this paper, we applied whole-exome sequencing and whole-genome sequencing to investigate the impact of ETBF-induced genetic changes on tumor formation. Additionally, we performed whole-genome sequencing of human colon organoids exposed to ETBF to validate the mutational patterns seen in our mouse models and begin to understand their relevance in human colon epithelial cells. The results of this study highlight the importance of ETBF colonization in the development of sporadic CRC and in individuals with hereditary tumor conditions, such as Lynch syndrome and familial adenomatous polyposis (FAP).
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http://dx.doi.org/10.1128/spectrum.01055-22DOI Listing
May 2022

Charge-Storage Nickel Substrate-Boosted CuP Nanosheet for the Electrochemical Oxygen Evolution Reaction.

Inorg Chem 2022 May 19. Epub 2022 May 19.

Department of Applied Chemistry, School of Science, Anhui Agricultural University, Hefei 230036, China.

The electrochemical oxygen evolution reaction (OER) is an essential anodic reaction that converts sustainable energy into chemical fuels, as it can provide protons and electrons. One of the most challenging research directions for the practical application of the OER is the elevation of the activity of noble-metal-free electrocatalysts. Here, we report that the nickel foam can be used as an electron-deficient substrate to tune the surface oxidation state of catalytic electrodes and thus boost the OER activity of CuP nanosheets via a charge-storage mechanism. The as-obtained self-standing CuP/Ni electrodes delivered a current density of 220 mA cm at 370 mV overpotential, which is approximately 5.5 times higher than the benchmarked IrO on nickel foam. This work sheds some new light on the design of low-cost electrocatalysts or electrodes with high activity for the electrochemical OER.
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http://dx.doi.org/10.1021/acs.inorgchem.2c00862DOI Listing
May 2022

The Efficacy of Acupuncture on Patients with Erectile Dysfunction: A Review.

Evid Based Complement Alternat Med 2022 9;2022:4807271. Epub 2022 May 9.

Department of Andrology, Xiyuan Hospital of China Academy of Chinese Medical Sciences, 1 Caochang, Xiyuan, Beijing 100091, China.

Erectile dysfunction (ED) is one of the most common sexual dysfunctions in men. The prevalence of ED has been increasing in recent years, which has critically affected male reproductive health and quality of life. According to various guidelines, phosphodiesterase-5 inhibitors are the most commonly recommended drugs for treating ED. However, many patients turn to alternative therapies because of adverse reactions, such as headache, and the poor efficacy of these drugs. Acupuncture is a long-established treatment in traditional Chinese medicine (TCM) and has been approved by the World Health Organization for improving penile erection as well as other discomforts in patients. However, previous systematic reviews have not discussed the characteristics and the related mechanisms of acupuncture treatment. Therefore, this study focuses on summarizing the characteristics and advantages of TCM in acupuncture treatment for ED based on relevant literature and on predicting and analyzing the related mechanisms.
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http://dx.doi.org/10.1155/2022/4807271DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9110168PMC
May 2022

Mo C Nanoparticles Embedded in Carbon Nanowires with Surface Pseudocapacitance Enables High-Energy and High-Power Sodium Ion Capacitors.

Small 2022 May 18:e2200805. Epub 2022 May 18.

Foshan Xianhu Laboratory of the Advanced Energy Science and Technology Guangdong Laboratory, Xianhu hydrogen Valley, Foshan, 528200, P. R. China.

Electrochemical sodium-ion storage technologies have become an indispensable part in the field of large-scale energy storage systems owing to the widespread and low-cost sodium resources. Molybdenum carbides with high electron conductivity are regarded as potential sodium storage anode materials, but the comprehensive sodium storage mechanism has not been studied in depth. Herein, Mo C nanowires (MC-NWs) in which Mo C nanoparticles are embedded in carbon substrate are synthesized. The sodium-ion storage mechanism is further systematically studied by in/ex situ experimental characterizations and diffusion kinetics analysis. Briefly, it is discovered that a faradaic redox reaction occurs in the surface amorphous molybdenum oxides on Mo C nanoparticles, while the inner Mo C is unreactive. Thus, the as-synthesized MC-NWs with surface pseudocapacitance display excellent rate capability (a high specific capacity of 76.5 mAh g at 20 A g ) and long cycling stability (a high specific capacity of 331.2 mAh g at 1 A g over 1500 cycles). The assembled original sodium ion capacitor displays remarkable power density and energy density. This work provides a comprehensive understanding of the sodium storage mechanism of Mo C materials, and constructing pseudocapacitive materials is an effective way to achieve sodium-ion storage devices with high power and energy density.
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http://dx.doi.org/10.1002/smll.202200805DOI Listing
May 2022

Infectivity versus fatality of SARS-CoV-2 mutations and influenza.

Int J Infect Dis 2022 May 15. Epub 2022 May 15.

Department of Mathematical and Statistical Sciences, University of Alberta, Edmonton, Alberta T6G 2R3, Canada. Electronic address:

Objectives: Due to the spread of the Omicron variant, many countries have experienced COVID-19 case numbers unseen since the start of the pandemic. We aimed to compare the epidemiological characteristics of Omicron with prior variants and different strains of influenza, to provide context for public health responses.

Methods: We developed transmission models for SARS-CoV-2 variants as well as influenza, in which transmission, death, and vaccination rates were taken to be time-varying. We fit our model based on publicly available data in South Africa, the United States and Canada. We used this model to evaluate the relative transmissibility and mortality of Omicron compared to previous variants and influenza.

Results: We find that Omicron is more transmissible and less fatal than both seasonal and 2009 H1N1 influenza, as well as the Delta variant; these characteristics make Omicron epidemiologically more similar to influenza than it is to Delta. We estimate that as of February 7, 2022, booster doses have prevented 4.29×10 and 1.14×10 Omicron infections in the United States and Canada, respectively.

Conclusions: Our findings indicate that the high infectivity of Omicron will keep COVID-19 endemic, similarly to influenza. However, due to Omicron's lower fatality rate, our work suggests that human populations living with SARS-CoV-2 is most likely.
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http://dx.doi.org/10.1016/j.ijid.2022.05.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9107628PMC
May 2022

Machine Learning-Assisted Sensor Array Based on Poly(amidoamine) (PAMAM) Dendrimers for Diagnosing Alzheimer's Disease.

ACS Sens 2022 May 18;7(5):1315-1322. Epub 2022 May 18.

State Key Laboratory of Natural Medicines and National R&D Center for Chinese Herbal Medicine Processing, Department of Food Quality and Safety, College of Engineering, China Pharmaceutical University, Nanjing 211109, China.

Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder, and the early diagnosis of AD remains challenging. Here we have developed a fluorescent sensor array composed of three modified polyamidoamine dendrimers. Proteins of various properties were differentiated via this array with 100% accuracy, proving the rationality of the array's design. The mechanism of the fluorescence response was discussed. Furthermore, the robust three-element array enables parallel detection of multiple Aβ40/Aβ42 aggregates (0.5 μM) in diverse interferents, serum media, and cerebrospinal fluid (CSF) with high accuracy, through machine learning algorithms, demonstrating the tremendous potential of the sensor array in Alzheimer's disease diagnosis.
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http://dx.doi.org/10.1021/acssensors.2c00132DOI Listing
May 2022
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