Publications by authors named "Hao Lu"

533 Publications

Establishment of noninvasive diabetes risk prediction model based on tongue features and machine learning techniques.

Int J Med Inform 2021 Feb 22;149:104429. Epub 2021 Feb 22.

School of Basic Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China. Electronic address:

Background: Diabetes is a chronic noncommunicable disease with high incidence rate. Diabetics without early diagnosis or standard treatment may contribute to serious multisystem complications, which can be life threatening. Timely detection and intervention of prediabetes is very important to prevent diabetes, because it is inevitable in the development and progress of the disease.

Objective: Our objective was to establish the predictive model that can be applied to evaluate people with blood glucose in high and critical state.

Methods: We established the diabetes risk prediction model formed by a combined TCM tongue diagnosis with machine learning techniques. 1512 subjects were recruited from the hospital. After data preprocessing, we got the dataset 1 and dataset 2. Dataset 1 was used to train classical machine learning model, while dataset 2 was used to train deep learning model. To evaluate the performance of the prediction model, we used Classification Accuracy(CA), Precision, Recall, F1-score, Precision-Recall curve(P-R curve), Area Under the Precision-Recall curve(AUPRC), Receiver Operating Characteristic curve(ROC curve), Area Under the Receiver Operating Characteristic curve(AUROC), then selected the best diabetes risk prediction model.

Results: On the test set of dataset 1, the CA of non-invasive Stacking model was 71 %, micro average AUROC was 0.87, macro average AUROC was 0.84, and micro average AUPRC was 0.77. In the critical blood glucose group, the AUROC was 0.84, AUPRC was 0.67. In the high blood glucose group, AUROC was 0.87, AUPRC was 0.83. On the validation set of dataset 2, the CA of ResNet50 model was 69 %, micro average AUROC was 0.84, macro average AUROC was 0.83, and micro average AUPRC was 0.73. In the critical blood glucose group, AUROC was 0.88, AUPRC was 0.71. In the high blood glucose group, AUROC was 0.80, AUPRC was 0.76. On the test set of dataset 2, the CA of ResNet50 model was 65 %, micro average AUROC was 0.83, macro average AUROC was 0.82, and micro average AUPRC was 0.71. In the critical blood glucose group, the prediction of AUROC was 0.84, AUPRC was 0.60. In the high blood glucose group, AUROC was 0.87, AUPRC was 0.71.

Conclusions: Tongue features can improve the prediction accuracy of the diabetes risk prediction model formed by classical machine learning model significantly. In addition to the excellent performance, Stacking model and ResNet50 model which were recommended had non-invasive operation and were easy to use. Stacking model and ResNet50 model had high precision, low false positive rate and low misdiagnosis rate on detecting hyperglycemia. While on detecting blood glucose value in critical state, Stacking model and ResNet50 model had a high sensitivity, a low false negative rate and a low missed diagnosis rate. The study had proved that the differential changes of tongue features reflected the abnormal glucose metabolism, thus the diabetes risk prediction model formed by a combined TCM tongue diagnosis and machine learning technique was feasible.
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http://dx.doi.org/10.1016/j.ijmedinf.2021.104429DOI Listing
February 2021

An NKX2-1 and TP63 dual fluorescent reporter for the investigation of human lung basal cell biology.

Sci Rep 2021 Feb 25;11(1):4712. Epub 2021 Feb 25.

Institute of Medical Biology, Agency for Science Technology and Research (A∗STAR), 8A Biomedical Grove, #06-06 Immunos, Singapore, 138648, Singapore.

Basal cells are multipotent stem cells responsible for the repair and regeneration of all the epithelial cell types present in the proximal lung. In mice, the elusive origins of basal cells and their contribution to lung development were recently revealed by high-resolution, lineage tracing studies. It however remains unclear if human basal cells originate and participate in lung development in a similar fashion, particularly with mounting evidence for significant species-specific differences in this process. To address this outstanding question, in the last several years differentiation protocols incorporating human pluripotent stem cells (hPSC) have been developed to produce human basal cells in vitro with varying efficiencies. To facilitate this endeavour, we introduced tdTomato into the human TP63 gene, whose expression specifically labels basal cells, in the background of a previously described hPSC line harbouring an NKX2-1 reporter allele. The functionality and specificity of the NKX2-1;TP63 hPSC line was validated by directed differentiation into lung progenitors as well as more specialised lung epithelial subtypes using an organoid platform. This dual fluorescent reporter hPSC line will be useful for tracking, isolating and expanding basal cells from heterogenous differentiation cultures for further study.
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http://dx.doi.org/10.1038/s41598-021-83825-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7907081PMC
February 2021

Measurement consistency of dynamic stretching muscle stiffness evaluated using shear wave elastography: comparison among different stretched levels and ROI sizes.

Med Ultrason 2021 Feb;23(1):55-61

Department of Ultrasound, Shenzhen Hospital of Guangzhou University of Chinese Medicine, Shenzhen, Guangdong, China.

Aim: To investigate the reliability of quantitative analysis of dynamic stretching muscle stiffness using shear wave elas-tography (SWE), and to evaluate the influence of stretched levels and region of interest (ROI) sizes on the repeatability of SWE measurements.

Materials And Methods: SWE videos of the gastrocnemius medius were collected during ankle movement from plantar flexion (PF) 40° to dorsiflexion (DF) 30°. Shear wave imageswere collected of ankle angles at PF 25°, 0°, DF 15°, and DF 30°, representing the slack status, mildly stretched level, moderately stretched level, and maximal stretched level of the gastrocnemius medius, respectively. ROI circles with diameters of 2 mm, 5 mm, and 8 mm were applied to measure the shear modulus. Intra-observer, and inter-observer repeatability of the measurements were compared among different stretched levels and ROI sizes.

Results: Twenty-one healthy volunteers were enrolled. Muscle stiffness increased as the ankle DF increased. Intraclass correlation coefficients (ICCs) of intra-observer and inter-observer repeatability obtained for ROI sizes of 2 mm, 5 mm and 8 mm indicated good to excellent repeatability at all stretched levels.

Conclusions: Shear wave elastography appeared to be a reliable tool to evaluate the dynamic stretching muscle stiffness with satisfactory repeatability at various stretched levels of gastrocnemius medius. Good to excellent repeatability was found using different ROI sizes.
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http://dx.doi.org/10.11152/mu-2731DOI Listing
February 2021

A review of treatment technologies for produced water in offshore oil and gas fields.

Sci Total Environ 2021 Jan 30;775:145485. Epub 2021 Jan 30.

School of Mechanical and Power Engineering, East China University of Science and Technology, Shanghai 200237, PR China. Electronic address:

Offshore oil and gas production is increasingly growing popular globally. Produced water (PW), which is the largest byproduct of oil and gas production, is a complex mixture of dissolved and undissolved organic and inorganic substances. PW contributes considerably to oil pollution in the offshore petroleum and gas industry owing to the organic substances, which mainly include hydrocarbons; this is a major concern to researchers because of the long-term adverse effects on the ecosystem. Since the development of offshore petroleum and gas industry, the PW treatment process has been classified into pretreatment, standard-reaching treatment, and advanced purification treatment based on the characteristics of PW and has been coupled with the environmental, economic, and regulatory considerations. The mechanism, design principle, application, and development of conventional technologies for PW treatment, such as gravity and enhanced gravity sedimentation, hydrocyclone, gas flotation, and medium filtration, are summarized in this study. Novel methods for further application, such as tubular separation, combined fibers coalescence, and membrane separation, are also discussed. Enhancement of treatment with multiple physical fields and environmentally friendly chemical agents, coupled with information control technology, would be the preferred PW treatment approach in the future. Moreover, the PW treatment system should be green, efficient, secure, and intelligent to satisfy the large-scale, unmanned, and abyssal exploration of offshore oil and gas production in the future.
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http://dx.doi.org/10.1016/j.scitotenv.2021.145485DOI Listing
January 2021

Type III Resistant Starch Prepared from Debranched Starch: Structural Changes under Simulated Saliva, Gastric, and Intestinal Conditions and the Impact on Short-Chain Fatty Acid Production.

J Agric Food Chem 2021 Mar 22;69(8):2595-2602. Epub 2021 Feb 22.

The State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China.

Type III resistant starch (RS3) has high resistance to enzymatic digestibility and benefits colonic bacteria by producing short-chain fatty acids (SCFAs) fermentation. Studies have delineated RS preparation and the description of RS fractions with different types of starch, but the digestion process has received little attention. The molecular and crystalline structure changes, thermal properties, and SCFA content of RS3 obtained from debranched starch were investigated in simulated salivary, gastric, and intestinal digestion systems. The average degree of polymerization and the melting enthalpy change of the digested RS3 residues increased; a high molecular order was reflected by the higher relative crystallinity. Fine structural changes suggested that enzyme-resistant starch might form during digestion by the rearrangement of short amylose chains into enzyme-resistant structures with higher relative crystallinity. After fermentation of human feces, RS3 increased the SCFA content, especially of butyric acid, indicating that this recrystallized RS3 could be a new prebiotic product.
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http://dx.doi.org/10.1021/acs.jafc.0c07664DOI Listing
March 2021

Intra-Individual Comparison of 18F-PSMA-1007 and 18F-FDG PET/CT in the Evaluation of Patients With Prostate Cancer.

Front Oncol 2020 1;10:585213. Epub 2021 Feb 1.

Radiation Oncology Key Laboratory of Sichuan Province, PET/CT Centre, Sichuan Cancer Hospital, Chengdu, China.

Purpose: 18F labelled PSMA-1007 presents promising results in detecting prostate cancer (PC), while some pitfalls exists meanwhile. An intra-individual comparison of 18F-FDG and 18F-PSMA-1007 in patients with prostate cancer were aimed to be performed in the present study. Then, the pitfalls of 18F-PSMA-1007 PET/CT in imaging of patients with prostate cancer were analyzed.

Methods And Material: 21 prostate cancer patients underwent 18F-PSMA-1007 PET/CT as well as 18F-FDG PET/CT before treatment. All positive lesions were noticed in both 18F-PSMA-1007 PET/CT and 18F-FDG PET/CT, then differentiated PC metastasis from benign lesions. the SUVmax, SUVmean and TBR of lesions, up to 10 metastases and 10 benign lesions per patients were recorded (5 for bone, 5 for soft tissue metastasis ). The distribution of positive lesions were analyzed for two imaging. Detection rates, SUVmax, SUVmean and TBR in 18F-PSMA-1007 PET/CT and 18F-FDG PET/CT were compared, respectively. The optimal cut-off values of SUVmax, SUVmean for metastases vs. benign lesions was found through areas under ROC in 18F-PSMA-1007.

Results: The detection rates of primary lesions in 18F-PSMA-1007 PET/CT was higher than that of 18F-FDG PET/CT(100% (21/21) vs. 67%(14/21)). For extra- prostatic lesions, 18F-PSMA-1007 PET/CT revealed 124 positive lesions, 49(49/124, 40%) attributed to a benign origin; 18F-FDG PET/CT revealed 68 positive lesions, 14(14/68, 21%) attributed to a benign origin. The SUVmax, SUVmean, TBR of primary tumor in 18F-PSMA-1007 PET/CT was higher than that in 18F-FDG PET/CT (15.20 vs. 4.20 for SUVmax; 8.70 vs. 2.80 for SUVmean; 24.92 vs. 4.82 for TBR, respectively); The SUVmax, SUVmean, TBR of metastases in 18F-PSMA-1007 PET/CT was higher than that in 18F-FDG PET/CT (10.72 vs. 4.42 for SUVmax; 6.67 vs. 2.59 for SUVmean; The TBR of metastases was 13.3 vs. 7.91). For 18F-FDG PET/CT, the SUVmax, SUVmean in metastases was higher than that in benign lesions (4.42 vs. 3.04 for SUVmax, 2.59 vs. 1.75 for SUVmean, respectively). Similarly, for 18F-PSMA-1007 PET/CT, the SUVmax, SUVmean in metastases was significantly higher than that in benign lesions(10.72 vs. 3.14 for SUVmax, 6.67 vs. 1.91 for SUVmean, respectively), ROC suggested that SUVmax=7.71, SUVmean=5.35 might be the optimal cut-off values for metastases vs. benign lesions.

Conclusion: The pilot study suggested that 18F-PSMA-1007 showed superiority over 18F-FDG because its high detecting rate of PC lesions and excellent tumor uptake. While non-tumor uptake in 18F-PSMA-1007 may lead to misdiagnosis, recognizing these pitfalls and careful analysis can improve the accuracy of diagnosis.
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http://dx.doi.org/10.3389/fonc.2020.585213DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7884904PMC
February 2021

Fiber coalescence treatment of oily wastewater: A new theory and application.

J Hazard Mater 2021 Jan 21;412:125188. Epub 2021 Jan 21.

National Engineering Laboratory for Industrial Wastewater Treatment, East China University of Science and Technology, Shanghai 200237, PR China. Electronic address:

Oil pollution from produced water in the offshore petroleum industry is one of the most serious marine pollutants worldwide, and efficient separation technology is crucial for the control of oil pollutant emission. Medium coalescence is an efficient oil-water separation technology, but its theory is lacking and the development is slow. In this work, the microscopic mechanism of fiber coalescence was revealed, and found that the effective collision positions were the three-phase contact line and the exposed fiber surface. Further, a theoretical model for calculating the separation performance of a fiber bed was established. For a given inlet droplet size distribution and bed geometric parameters, the outlet droplet size distribution and the total separation efficiency of the fiber bed can be predicted. Then, an Ω-shaped woven method composed of oil-wet fibers and oil-phobic fibers was designed and the separation performance of the fiber beds prepared by the method and the influence law of various parameters were clarified through macroscopic experiment. Finally, the novel technology achieved its first engineering application on an offshore platform, with the average oil content of the outlet was less than 25 mg/L, which could reform the current treatment process of produced water.
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http://dx.doi.org/10.1016/j.jhazmat.2021.125188DOI Listing
January 2021

Effects of surface condition of conductive electrospun nanofiber mats on cell behavior for nerve tissue engineering.

Mater Sci Eng C Mater Biol Appl 2021 Jan 10;120:111795. Epub 2020 Dec 10.

School of Chemistry, State Key Laboratory of Electrical Insulation and Power Equipments, MOE Key Laboratory for Non-Equilibrium Synthesis and Modulation of Condensed Matter, Xi'an Jiaotong University, Xi'an, Shaanxi, PR China. Electronic address:

Electrospun nanofibrous scaffold is a promising implant for peripheral nerve regeneration. Herein, to investigate the effect of surface morphological features and electrical properties of scaffolds on nerve cell behavior, we modified electrospun cellulose (EC) fibrous mats with four kind of soluble conductive polymers derivates (poly (N-(methacryl ethyl) pyrrole) (PMAEPy), poly (N-(2-hydroxyethyl) pyrrole) (PHEPy), poly (3-(Ethoxycarbonyl) thiophene) (P3ECT) and poly (3-thiophenethanol) (P3TE)) by an in-situ polymerization method. The morphological characterization showed that conductive polymers formed aggregated nanoparticles and coatings on the EC nanofibers with the increased fiber diameter further affected the surface properties. Compared with pure EC scaffold, more PC12 cells were adhered and grown on modified mats, with more integral and clearer cell morphology. The results of protein adsorption study indicated that modified EC mats could provide more protein adsorption site due to their characteristic surface morphology, which is beneficial to cell adhesion and growth. The results in this study suggested that these conductive polymers modified scaffolds with special surface morphology have potential applications in neural tissue engineering.
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http://dx.doi.org/10.1016/j.msec.2020.111795DOI Listing
January 2021

Decoupled Two-Stage Crowd Counting and Beyond.

IEEE Trans Image Process 2021 12;30:2862-2875. Epub 2021 Feb 12.

One of appealing approaches to counting dense objects, such as crowd, is density map estimation. Density maps, however, present ambiguous appearance cues in congested scenes, rendering infeasibility in identifying individuals and difficulties in diagnosing errors. Inspired by an observation that counting can be interpreted as a two-stage process, i.e., identifying possible object regions and counting exact object numbers, we introduce a probabilistic intermediate representation termed the probability map that depicts the probability of each pixel being an object. This representation allows us to decouple counting into probability map regression (PMR) and count map regression (CMR). We therefore propose a novel decoupled two-stage counting (D2C) framework that sequentially regresses the probability map and learns a counter conditioned on the probability map. Given the probability map and the count map, a peak point detection algorithm is derived to localize each object with a point under the guidance of local counts. An advantage of D2C is that the counter can be learned reliably with additional synthesized probability maps. This addresses important data deficiency and sample imbalanced problems in counting. Our framework also enables easy diagnoses and analyses of error patterns. For instance, we find that, the counter per se is sufficiently accurate, while the bottleneck appears to be PMR. We further instantiate a network D2CNet in our framework and report state-of-the-art counting and localization performance across 6 crowd counting benchmarks. Since the probability map is a representation independent of visual appearance, D2CNet also exhibits remarkable cross-dataset transferability. Code and pretrained models are made available at: https://git.io/d2cnet.
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http://dx.doi.org/10.1109/TIP.2021.3055631DOI Listing
February 2021

HDAC1-mediated deacetylation of HIF1α prevents atherosclerosis progression by promoting miR-224-3p-mediated inhibition of FOSL2.

Mol Ther Nucleic Acids 2021 Mar 5;23:577-591. Epub 2020 Nov 5.

Stroke Center, the First Affiliated Hospital, Jinan University, Guangzhou 510630, P.R. China.

We intended to characterize functional relevance of microRNA (miR)-224-3p in endothelial cell (EC) apoptosis and reactive oxygen species (ROS) accumulation in atherosclerosis, considering also the integral involvement of histone deacetylase 1 (HDAC1)-mediated hypoxia-inducible factor-1α (HIF1α) deacetylation. The binding affinity between miR-224-3p and Fos-like antigen 2 (FOSL2) was predicted and validated. Furthermore, we manipulated miR-224-3p, FOSL2, HDAC1, and HIF1α expression in oxidized low-density lipoprotein (ox-LDL)-induced ECs, aiming to clarify their effects on cell activities, inflammation, and ROS level. Additionally, we examined the impact of miR-224-3p on aortic atherosclerotic plaque and lesions in a high-fat-diet-induced atherosclerosis model in ApoE mice. Clinical atherosclerotic samples and ox-LDL-induced human aortic ECs (HAECs) exhibited low HDAC1/miR-224-3p expression and high HIF1α/FOSL2 expression. miR-224-3p repressed EC cell apoptosis, inflammatory responses, and intracellular ROS levels through targeting FOSL2. HIF1α reduced miR-224-3p expression to accelerate EC apoptosis and ROS accumulation. Moreover, HDAC1 inhibited HIF1α expression by deacetylation, which in turn enhanced miR-224-3p expression to attenuate EC apoptosis and ROS accumulation. miR-224-3p overexpression reduced atherosclerotic lesions . In summary, HDAC1 overexpression may enhance the anti-atherosclerotic and endothelial-protective effects of miR-224-3p-mediated inhibition of FOSL2 by deacetylating HIF1α, underscoring a novel therapeutic insight against experimental atherosclerosis.
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http://dx.doi.org/10.1016/j.omtn.2020.10.044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7815465PMC
March 2021

Role of Water in CaCO Biomineralization.

J Am Chem Soc 2021 Feb 20;143(4):1758-1762. Epub 2021 Jan 20.

Max Planck Institute for Polymer Research, Ackermannweg 10, 55128 Mainz, Germany.

Biomineralization occurs in aqueous environments. Despite the ubiquity and relevance of CaCO biomineralization, the role of water in the biomineralization process has remained elusive. Here, we demonstrate that water reorganization accompanies CaCO biomineralization for sea urchin spine generation in a model system. Using surface-specific vibrational spectroscopy, we probe the water at the interface of the spine-associated protein during CaCO mineralization. Our results show that, while the protein structure remains unchanged, the structure of interfacial water is perturbed differently in the presence of both Ca and CO compared to the addition of only Ca. This difference is attributed to the condensation of prenucleation mineral species. Our findings are consistent with a nonclassical mineralization pathway for sea urchin spine generation and highlight the importance of protein hydration in biomineralization.
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http://dx.doi.org/10.1021/jacs.0c11976DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7877725PMC
February 2021

Enzastaurin enhances ATRA-induced differentiation of acute myeloid leukemia cells.

Am J Transl Res 2020 15;12(12):7836-7854. Epub 2020 Dec 15.

Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine No. 197 Rui-jin Road II, Shanghai 200025, China.

All-trans retinoic acid (ATRA) is considered to be the sole clinically-useful differentiating agent in the treatment of acute myeloid leukemia (AML). However, ATRA has been effective only in acute promyelocytic leukemia (APL) but not other subtypes of AML. Therefore, discovering strategies to sensitize cells to ATRA may lead to the development of ATRA-based treatments in non-APL AML patients. In the present study, a clinically-achievable concentration of enzastaurin enhanced ATRA-induced differentiation in AML cell lines, HL-60 and U937 as well as non-APL AML primary cells. Furthermore, it also restored ATRA sensitivity in ATRA-resistant cell line, HL-60Res. Mechanistically, in all these cell lines, enzastaurin-ATRA (enz-ATRA) co-treatment enhanced the protein levels of PU.1, CCAAT/enhancer-binding protein β (C/EBPβ) and C/EBPε. The activity of protein kinase C β (PKCβ) was suppressed by enz-ATRA treatment in HL-60 and HL-60Res cells. However, another PKCβ-selective inhibitor mimicked the cellular and molecular effects of enzastaurin only in HL-60 cells. Furthermore, in U937 cells, enz-ATRA activated MEK and ERK, and a MEK-specific inhibitor suppressed enz-ATRA-triggered differentiation and reduced the protein levels of PU.1, C/EBPβ and C/EBPε. Enz-ATRA activated Akt in HL-60 and HL-60Res cells. However, an Akt inhibitor blocked enz-ATRA-triggered differentiation and restored the protein levels of PU.1, C/EBPβ and C/EBPε only in HL-60Res cells. Therefore, PKCβ inhibition, MEK/ERK and Akt activation were involved in enz-ATRA-induced differentiation in HL-60, U937 and HL-60Res cells, respectively, via modulation of the protein levels of C/EBPβ, C/EBPε and PU.1. Taken together, our findings may help to guide novel therapeutic strategies for AML patients.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7791522PMC
December 2020

Spherical Nucleic Acids for Topical Treatment of Hyperpigmentation.

J Am Chem Soc 2021 Jan 12;143(3):1296-1300. Epub 2021 Jan 12.

Department of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts 02115, United States.

Oligonucleotide-based materials such as spherical nucleic acid (SNA) have been reported to exhibit improved penetration through the epidermis and the dermis of the skin upon topical application. Herein, we report a self-assembled, skin-depigmenting SNA structure, which is based upon a bifunctional oligonucleotide amphiphile containing an antisense oligonucleotide and a tyrosinase inhibitor prodrug. The two components work synergistically to increase oligonucleotide cellular uptake, enhance drug solubility, and promote skin penetration. The particles were shown to reduce melanin content in B16F10 melanoma cells and exhibited a potent antimelanogenic effect in an ultraviolet B-induced hyperpigmentation mouse model.
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http://dx.doi.org/10.1021/jacs.0c12044DOI Listing
January 2021

Electrochemical detection of bisphenols in food: A review.

Food Chem 2021 Jun 5;346:128895. Epub 2021 Jan 5.

College of Food Engineering and Nutritional Science, Shaanxi Normal University, Xi'an 710119, China; University Key Laboratory of Food Processing Byproducts for Advanced Development and High Value Utilization, Xi'an 710119, China. Electronic address:

Bisphenols (BPs) are worldwide used organic compounds in plastics, belonging to the group of endocrine disrupting chemicals (EDCs) which exhibits endocrine disruption to beings. Migration of BPs from food contact materials like plastic containers, epoxy coatings in metal cans and thermal papers, would results in bioaccumulation of BPs in human beings, causing adverse health effects. Therefore, sensitive and selective determination of BPs in food is needed. Among different strategies have been explored for the detection of BPs, electrochemical sensors with relatively high sensitivity and fast response are promising. This paper is devoted to comprehensively review the developed electrochemical methods for BPs sensing in food, so that to find a direction for developing low cost, high accuracy and compatibility sensors toward the sensitive and selective detection of BPs. Different electrochemical technologies categorized by recognition agents, aptamers, enzymes, molecularly imprinted polymers and nanomaterials are discussed and summarized in their mechanisms, usages, merits and limitations. The challenges and further perspectives in the development of electrochemical sensors is also discussed.
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http://dx.doi.org/10.1016/j.foodchem.2020.128895DOI Listing
June 2021

Auranofin Has Advantages over First-Line Drugs in the Treatment of Severe Infections.

Antibiotics (Basel) 2020 Dec 30;10(1). Epub 2020 Dec 30.

Hubei Biopesticide Engineering Research Centre, Wuhan 430070, China.

Streptococcal toxic shock-like syndrome (STSLS) likely occurs when an individual is infected with the () epidemic strain and is characterized by a cytokine storm, multiple organ dysfunction syndrome (MODS) and a high incidence of mortality despite adequate treatment. A number of antibiotics exhibit excellent bactericidal effects in vivo, such as fluoroquinolones, aminoglycosides (gentamicin) and β-lactams (penicillin G, ceftiofur, or amoxicillin), but are less effective for treating STSLS. Therefore, there is an urgent need to identify new compounds that can reduce the damage caused by STSLS. In the present study, we identified auranofin, an orally bioavailable FDA-approved anti-rheumatic drug as a candidate repurposed drug to treat severe infections. Our results showed that auranofin can bind to the functional domain of bacterial thioredoxin reductase, decreasing the reducing redox-responsive capacity of target bacteria and allowing for the killing of cells. We also observed that auranofin has antibacterial activity against other gram-positive bacteria, such as multidrug resistant Streptococcus pneumoniae (MDRSP), Streptococcus agalactiae, and vancomycin-resistant strains of Staphylococcus aureus. Additionally, auranofin is capable of eradicating intracellular present inside infected macrophage cells. Mouse model experimental results showed that auranofin could effectively reduce the mortality of mice infected with . Compared to the ampicillin treatment group, the survival rate of mice in the auranofin treatment group in severely infected model mice was significantly improved. These results suggest that auranofin has the potential for use as an effective antibiotic against
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http://dx.doi.org/10.3390/antibiotics10010026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7823847PMC
December 2020

Melatonin provides protection against cisplatin-induced ovarian damage and loss of fertility in mice.

Reprod Biomed Online 2020 Oct 8. Epub 2020 Oct 8.

Department of Gynecology and Obstetrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan Hubei, China. Electronic address:

Research Question: Can melatonin provide non-invasive ovarian protection against damage caused by cis-diamminedichloroplatinum (cisplatin) and preserve fertility in female cancer patients? And if so, what is the possible mechanism?

Design: Athymic BALB/c nude tumour-bearing female mice were used to demonstrate whether melatonin affects the antineoplastic effect when co-administrated with cisplatin. Sexually mature and newborn C57BL/6 female mice were used to evaluate the potential effects of melatonin on the ovarian follicle pool, pregnancy rate and litter number in cisplatin-treated mice. The ovaries underwent immunohistochemical, TdT (terminal deoxynucleotidyl transferase)-mediated dUTP nick-end labelling (TUNEL) and gene array analysis to explore the underlying mechanism. In addition, granulosa cells were isolated to investigate the potential protective mechanism of melatonin.

Results: Melatonin not only enhanced the anti-cancer effect of cisplatin in tumour-bearing nude mice, but also reduced ovarian toxicity and preserved long-term fertility in cisplatin-treated C57BL/6 female mice. When co-administrated, melatonin was able to reduce the DNA damage and toxic effects on lipid peroxidation in the ovaries caused by cisplatin. Specifically, melatonin was able to largely restore lipid peroxidation in granulosa cells and thus prevent ovarian follicles from being depleted.

Conclusions: Melatonin has the potential to be used as a chemotherapeutic adjuvant to simultaneously improve the outcome of anti-cancer treatment and preserve ovarian function during cisplatin chemotherapy. Notably, its properties of DNA protection and antioxidant effects on follicles may benefit female cancer survivors and prevent premature ovarian failure as well as fertility loss caused by chemotherapy.
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http://dx.doi.org/10.1016/j.rbmo.2020.10.001DOI Listing
October 2020

Hybrid Nonfused-Ring Electron Acceptors with Fullerene Pendant for High-Efficiency Organic Solar Cells.

ACS Appl Mater Interfaces 2021 Jan 29;13(1):1603-1611. Epub 2020 Dec 29.

Beijing Key Laboratory of Energy Conversion and Storage Materials, College of Chemistry, Beijing Normal University, Beijing 100875, China.

The rapid advance of fused-ring electron acceptors (FREAs) has made them a potential substitute to fullerene-based acceptors and offered new avenues for the construction of organic solar cells (OSCs). Nonfused-ring acceptors (NFRAs) could significantly reduce the synthetic cost while achieving reasonable power conversion efficiencies (PCEs). Widely used fullerene acceptors have been applied as a second acceptor to regulate the morphology, absorption, and electron transport. To take full advantage of both nonfullerene and fullerene acceptors at the same time, we rationally designed and synthesized two novel NFRAs with phenyl-C-butyric acid methyl ester (PCBM) as the lateral pendent. With the incorporation of fullerene pendent in and , varied UV-vis absorption and photoluminescence (PL) quenching behaviors were observed, and isotropic diffraction patterns were obtained via grazing incidence wide-angle X-ray scattering (GIWAXS) measurements. The bulky, spherical, and electronic isotropic fullerene pendent could effectively suppress severe molecular aggregation and form the preferred blend morphology. This strategy significantly improved the efficiencies for exciton separation and charge collection relative to the control acceptor . Finally, the , , and fill factor (FF) of -based devices were simultaneously improved and an enhanced PCE of 13.55% was accomplished.
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http://dx.doi.org/10.1021/acsami.0c19632DOI Listing
January 2021

TasselNetV2+: A Fast Implementation for High-Throughput Plant Counting From High-Resolution RGB Imagery.

Authors:
Hao Lu Zhiguo Cao

Front Plant Sci 2020 7;11:541960. Epub 2020 Dec 7.

Key Laboratory of Image Processing and Intelligent Control, School of Artificial Intelligence and Automation, Huazhong University of Science and Technology, Wuhan, China.

Plant counting runs through almost every stage of agricultural production from seed breeding, germination, cultivation, fertilization, pollination to yield estimation, and harvesting. With the prevalence of digital cameras, graphics processing units and deep learning-based computer vision technology, plant counting has gradually shifted from traditional manual observation to vision-based automated solutions. One of popular solutions is a state-of-the-art object detection technique called Faster R-CNN where plant counts can be estimated from the number of bounding boxes detected. It has become a standard configuration for many plant counting systems in plant phenotyping. Faster R-CNN, however, is expensive in computation, particularly when dealing with high-resolution images. Unfortunately high-resolution imagery is frequently used in modern plant phenotyping platforms such as unmanned aerial vehicles, engendering inefficient image analysis. Such inefficiency largely limits the throughput of a phenotyping system. The goal of this work hence is to provide an effective and efficient tool for high-throughput plant counting from high-resolution RGB imagery. In contrast to conventional object detection, we encourage another promising paradigm termed object counting where plant counts are directly regressed from images, without detecting bounding boxes. In this work, by profiling the computational bottleneck, we implement a fast version of a state-of-the-art plant counting model TasselNetV2 with several minor yet effective modifications. We also provide insights why these modifications make sense. This fast version, TasselNetV2+, runs an order of magnitude faster than TasselNetV2, achieving around 30 fps on image resolution of 1980 × 1080, while it still retains the same level of counting accuracy. We validate its effectiveness on three plant counting tasks, including wheat ears counting, maize tassels counting, and sorghum heads counting. To encourage the use of this tool, our implementation has been made available online at https://tinyurl.com/TasselNetV2plus.
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http://dx.doi.org/10.3389/fpls.2020.541960DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7750361PMC
December 2020

CFAP53 regulates mammalian cilia-type motility patterns through differential localization and recruitment of axonemal dynein components.

PLoS Genet 2020 Dec 21;16(12):e1009232. Epub 2020 Dec 21.

Laboratory for Organismal Patterning, RIKEN Center for Biosystems Dynamics Research, Kobe, Hyogo, Japan.

Motile cilia can beat with distinct patterns, but how motility variations are regulated remain obscure. Here, we have studied the role of the coiled-coil protein CFAP53 in the motility of different cilia-types in the mouse. While node (9+0) cilia of Cfap53 mutants were immotile, tracheal and ependymal (9+2) cilia retained motility, albeit with an altered beat pattern. In node cilia, CFAP53 mainly localized at the base (centriolar satellites), whereas it was also present along the entire axoneme in tracheal cilia. CFAP53 associated tightly with microtubules and interacted with axonemal dyneins and TTC25, a dynein docking complex component. TTC25 and outer dynein arms (ODAs) were lost from node cilia, but were largely maintained in tracheal cilia of Cfap53-/- mice. Thus, CFAP53 at the base of node cilia facilitates axonemal transport of TTC25 and dyneins, while axonemal CFAP53 in 9+2 cilia stabilizes dynein binding to microtubules. Our study establishes how differential localization and function of CFAP53 contributes to the unique motion patterns of two important mammalian cilia-types.
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http://dx.doi.org/10.1371/journal.pgen.1009232DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7817014PMC
December 2020

High-Throughput Rice Density Estimation from Transplantation to Tillering Stages Using Deep Networks.

Plant Phenomics 2020 21;2020:1375957. Epub 2020 Aug 21.

National Key Laboratory of Science and Technology on Multi-Spectral Information Processing, School of Artificial Intelligence and Automation, Huazhong University of Science and Technology, Wuhan, 430074 Hubei, China.

Rice density is closely related to yield estimation, growth diagnosis, cultivated area statistics, and management and damage evaluation. Currently, rice density estimation heavily relies on manual sampling and counting, which is inefficient and inaccurate. With the prevalence of digital imagery, computer vision (CV) technology emerges as a promising alternative to automate this task. However, challenges of an in-field environment, such as illumination, scale, and appearance variations, render gaps for deploying CV methods. To fill these gaps towards accurate rice density estimation, we propose a deep learning-based approach called the Scale-Fusion Counting Classification Network (SFCNet) that integrates several state-of-the-art computer vision ideas. In particular, SFCNet addresses appearance and illumination changes by employing a multicolumn pretrained network and multilayer feature fusion to enhance feature representation. To ameliorate sample imbalance engendered by scale, SFCNet follows a recent blockwise classification idea. We validate SFCNet on a new rice plant counting (RPC) dataset collected from two field sites in China from 2010 to 2013. Experimental results show that SFCNet achieves highly accurate counting performance on the RPC dataset with a mean absolute error (MAE) of 25.51, a root mean square error (MSE) of 38.06, a relative MAE of 3.82%, and a of 0.98, which exhibits a relative improvement of 48.2% w.r.t. MAE over the conventional counting approach CSRNet. Further, SFCNet provides high-throughput processing capability, with 16.7 frames per second on 1024 × 1024 images. Our results suggest that manual rice counting can be safely replaced by SFCNet at early growth stages. Code and models are available online at https://git.io/sfc2net.
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http://dx.doi.org/10.34133/2020/1375957DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7706318PMC
August 2020

A Novel Method Based on Multi-Island Genetic Algorithm Improved Variational Mode Decomposition and Multi-Features for Fault Diagnosis of Rolling Bearing.

Authors:
Tao Liang Hao Lu

Entropy (Basel) 2020 Sep 7;22(9). Epub 2020 Sep 7.

School of Artificial Intelligence and Data Science, Hebei University of Technology, Tianjin 300401, China.

Aiming at the problem that it is difficult to extract fault features from the nonlinear and non-stationary vibration signals of wind turbine rolling bearings, which leads to the low diagnosis and recognition rate, a feature extraction method based on multi-island genetic algorithm (MIGA) improved variational mode decomposition (VMD) and multi-features is proposed. The decomposition effect of the VMD method is limited by the number of decompositions and the selection of penalty factors. This paper uses MIGA to optimize the parameters. The improved VMD method is used to decompose the vibration signal into a number of intrinsic mode functions (IMF), and a group of components containing the most information is selected through the Holder coefficient. For these components, multi-features based on Renyi entropy feature, singular value feature, and Hjorth parameter feature are extracted as the final feature vector, which is input to the classifier to realize the fault diagnosis of rolling bearing. The experimental results prove that the proposed method can more effectively extract the fault characteristics of rolling bearings. The fault diagnosis model based on this method can accurately identify bearing signals of 16 different fault types, severity, and damage points.
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http://dx.doi.org/10.3390/e22090995DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7597321PMC
September 2020

Characterization of complexes formed between debranched starch and fatty acids having different carbon chain lengths.

Int J Biol Macromol 2021 Jan 2;167:595-604. Epub 2020 Dec 2.

College of Food Science and Engineering, Qingdao Agricultural University, Qingdao, Shandong Province, 266109, China. Electronic address:

Recently, amylose-lipid complexes have attracted widespread attention because of their various applications. However, DBS complexed with fatty acids of different carbon chain length are rarely studied. This study aimed to probe the complexation of DBS with saturated fatty acids having different carbon chain lengths (C6-C18). The results revealed that DBS was able to form V-type complexes with all the fatty acids considered. Compared to DBS, the relative crystallinity of the complexes increased 2-3 times. DBS with lauric acid and myristic acid formed three types V-type complexes (type I, type IIa, and type IIb). The complexing index followed the order of hexanoic acid > octanoic acid > capric acid > lauric acid > myristic acid > palmitic acid > stearic acid. Furthermore, lauric acid and myristic acid formed complexes with DBS more easily compared with other fatty acids.
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http://dx.doi.org/10.1016/j.ijbiomac.2020.11.198DOI Listing
January 2021

Effect of supports on plasma catalytic decomposition of toluene using in situ plasma DRIFTS.

J Hazard Mater 2021 Mar 8;405:124203. Epub 2020 Oct 8.

School of Environmental and Safety Engineering, Changzhou University, Jiangsu 213164, China. Electronic address:

Plasma catalysis technology has been demonstrated to be effective for the decomposition of volatile organic compounds (VOCs). It is highly desired to explore the effect of supports on VOCs oxidation processes during plasma catalysis. In this work, four supports of SiO, ZSM-5-300, ZSM-5-38 and γ-AlO loading with transition metal oxides were used to decompose toluene at room temperature. It was found that toluene decomposition with 1 wt%Mn/γ-AlO was highest, which was strongly proportional to the ozone decomposition ability of the catalyst. The plasma catalytic decomposition of toluene over 1 wt% MnO on different supports were characterized using in situ plasma diffuse reflectance infrared Fourier transform spectrometer. The results showed that 1 wt%Mn/γ-AlO could further catalyze toluene to carbonate and bicarbonate via the breakage of C-C bonds from benzoic acid, while that was difficult for 1 wt% Mn/SiO, 1 wt%Mn/ZSM-5-300 and 1 wt%Mn/ZSM-5-38. The reaction mechanism of toluene decomposition on different catalysts were proposed.
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http://dx.doi.org/10.1016/j.jhazmat.2020.124203DOI Listing
March 2021

Biologic-like In Vivo Efficacy with Small Molecule Inhibitors of TNFα Identified Using Scaffold Hopping and Structure-Based Drug Design Approaches.

J Med Chem 2020 12 1;63(23):15050-15071. Epub 2020 Dec 1.

Research and Early Development, Bristol Myers Squibb, 3551 Lawrenceville Road, Princeton, New Jersey 08540, United States.

Scaffold hopping and structure-based drug design were employed to identify substituted 4-aminoquinolines and 4-aminonaphthyridines as potent, small molecule inhibitors of tumor necrosis factor alpha (TNFα). Structure-activity relationships in both the quinoline and naphthyridine series leading to the identification of compound with excellent potency and pharmacokinetic profile are discussed. X-ray co-crystal structure analysis and ultracentrifugation experiments clearly demonstrate that these inhibitors distort the TNFα trimer upon binding, leading to aberrant signaling when the trimer binds to TNF receptor 1 (TNFR1). Pharmacokinetic-pharmacodynamic activity of compound in a TNF-induced IL-6 mouse model and in vivo activity in a collagen antibody-induced arthritis model, where it showed biologic-like in vivo efficacy, will be discussed.
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http://dx.doi.org/10.1021/acs.jmedchem.0c01732DOI Listing
December 2020

Enhanced neural differentiation of neural stem cells by sustained release of Shh from TG2 gene-modified EMSC co-culture in vitro.

Amino Acids 2021 Jan 27;53(1):11-22. Epub 2020 Nov 27.

State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, 214122, People's Republic of China.

As a promising cell therapy, neural crest-derived ectoderm mesenchymal stem cells (EMSCs) secrete high amounts of extracellular matrix (ECM) and neurotrophic factors, promoting neural stem cell (NSC) differentiation into neuronal lineages and aiding tissue regeneration. Additionally, the forced overexpression of secreted proteins can increase the therapeutic efficacy of the secretome. Tissue transglutaminase (TG2) is a ubiquitously expressed member of the transglutaminase family of calcium-dependent crosslinking enzymes, which can stabilize the ECM, inducing smart or living biomaterial to stimulate differentiation and enhance the neurogenesis of NSCs. In this study, we examined the neuronal differentiation of NSCs induced by TG2 gene-modified EMSCs (TG2-EMSCs) in a co-culture model directly. Two weeks after initiating differentiation, levels of the neuronal markers, tubulin beta 3 class III and growth-associated protein 43, were higher in NSCs in the TG2-EMSC co-culture group and those of the astrocytic marker glial fibrillary acidic protein were lower, compared with the control group. These results were confirmed by immunofluorescence, and laminin, fibronectin and sonic hedgehog (Shh) contributed to this effect. The results of western blot analysis and the enzyme-linked immunoassay showed that after TG2-EMSCs were co-cultured for 2 weeks, they expressed much higher levels of Shh than the control group. Moreover, the sustained release of Shh was observed in the TG2-EMSC co-culture group. Overall, our findings indicate that EMSCs can induce the differentiation of NSCs, of which TG2-EMSCs can promote the differentiation of NSCs compared with EMSCs.
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http://dx.doi.org/10.1007/s00726-020-02918-0DOI Listing
January 2021

Effects of salvianolate on myocardial perfusion after primary percutaneous catheter intervention in patients with ST-segment elevation myocardial infarction: a multicenter, randomized, double-blind, placebo-controlled study.

Ann Transl Med 2020 Sep;8(18):1185

Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai, China.

Background: Despite prompt revascularization following acute myocardial infarction, poor myocardial perfusion commonly occurs due to impaired microvascular circulation and is an independent predictor of adverse outcomes. The current trial sought to examine the effects of salvianolate on myocardial perfusion in patients with ST-segment-elevation myocardial infarction (STEMI) who were undergoing primary percutaneous coronary intervention (PCI).

Methods: This randomized, double-blind, placebo-controlled, multicenter study evaluated the effects of intravenous salvianolate on the achievement of complete epicardial and myocardial reperfusion after PCI, defined as thrombolysis in myocardial infarction flow grade 3 and thrombolysis in myocardial infarction myocardial perfusion grade 3. We also measured plasma total creatine kinase-mass band fraction (CK-MB)-estimated infarct size and echocardiography-derived left ventricular ejection fraction and recorded the 30-day clinical and safety outcomes. A total of 536 patients presenting with acute STEMI were randomized to receive either an i.v. infusion of salvianolate (n=265) or placebo (n=271).

Results: Salvianolate administration exerted beneficial effects on coronary microcirculation. There was a trend of reduced myocardial infarct size in the salvianolate group compared to the placebo group (P=0.070), although no significant difference in left ventricular ejection fraction was found between the two groups.

Conclusions: Salvianolate administration is associated with improved myocardial perfusion in patients with STEMI undergoing PCI. A larger study is required to assess the impact of this therapy on clinical cardiac outcomes.
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http://dx.doi.org/10.21037/atm-20-6081DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7576095PMC
September 2020

Ultrastretchable, Tough, Antifreezing, and Conductive Cellulose Hydrogel for Wearable Strain Sensor.

ACS Appl Mater Interfaces 2020 Nov 13;12(47):53247-53256. Epub 2020 Nov 13.

Key Laboratory of Synthetic and Natural Functional Molecule of Ministry of Education, College of Chemistry and Materials Science, Northwest University, Xi'an, Shaanxi 710127, China.

Conductive hydrogels have shown great potential in the field of flexible strain sensors. However, their application is greatly limited due to the low conductivity and poor mechanical properties at subzero temperatures. Herein, an ultrastretchable, tough, antifreezing, and conductive cellulose hydrogel was fabricated by grafting acrylonitrile and acrylamide copolymers onto the cellulose chains in the presence of zinc chloride using ceric ammonium nitrate as the initiator. The resulting hydrogel exhibited ultrastretchability (1730%), excellent tensile strength (160 kPa), high elasticity (90%), good toughness (1074.7 kJ/m), and fatigue resistance property due to the existence of dipole-dipole and multiple hydrogen-bonding interactions on the hydrogel network. In addition, the introduced zinc chloride endowed the cellulose-based hydrogel with remarkable electric conductivity (1.54 S/m) and excellent antifreezing performance (-33 °C). Finally, the hydrogel showed high sensitivity and stability to monitor human activities. In summary, this work presented a facile strategy to construct conductive hydrogel with excellent antifreezing and mechanical properties simultaneously, which showed great potential for wearable strain sensors.
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http://dx.doi.org/10.1021/acsami.0c14935DOI Listing
November 2020

Enhancing the Photovoltaic Performance of a Benzo[][1,2,5]thiadiazole-Based Polymer Donor via a Non-Fullerene Acceptor Pairing Strategy.

ACS Appl Mater Interfaces 2020 Nov 10;12(47):53021-53028. Epub 2020 Nov 10.

Key Laboratory of Energy Conversion and Storage Materials, College of Chemistry, Beijing Normal University, Beijing 100875, P. R. China.

As a well-known electron-withdrawing group, benzo[][1,2,5]thiadiazole (BT) has been intensively studied and adopted to construct polymer donors with tunable band gaps. However, polymer solar cells (PSCs) with BT-based polymer donors, limited by the weak absorption and inflexible energy level of fullerene derivatives, usually suffer mediocre power conversion efficiencies (PCEs). Here, through subtly tailoring a BT unit with asymmetric fluoro and alkyloxy groups and judiciously pairing a BT-based polymer donor with three narrow band gap non-fullerene acceptors (e.g., IEICO-4F, ITOIC-2F, and IDTCN-O), active layers with complementary absorption spectra, small lowest unoccupied molecular orbital (LUMO) offsets, and preferred morphologies have been achieved. Consequently, PSCs with excellent values (over 20 mA/cm) and high PCEs up to 12.33% have been obtained. To the best of our knowledge, the value of 12.33% is among the highest PCEs for BT-based polymers in binary PSCs so far. This work demonstrates that the cooperative effect of energy levels, absorption spectra, and morphologies between the donors and acceptors is crucial for governing the performance of organic photovoltaics.
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http://dx.doi.org/10.1021/acsami.0c17571DOI Listing
November 2020

Correction: GATA3 suppresses human fibroblasts-induced metastasis of clear cell renal cell carcinoma via an anti-IL6/STAT3 mechanism.

Cancer Gene Ther 2020 Dec;27(12):979-982

Shanghai Key Laboratory of Acupuncture Mechanism and Acupoint Function, Fudan University, Shanghai, 200433, China.

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http://dx.doi.org/10.1038/s41417-020-00229-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7725668PMC
December 2020

Association of lipoprotein (a) and in-hospital outcomes in patients with acute coronary syndrome undergoing percutaneous coronary intervention.

Postgrad Med 2020 Nov 18:1-7. Epub 2020 Nov 18.

Department of Cardiology, Fuwai Hospital Chinese Academy Science of Medical Science , Shenzhen, Guangdong, China.

: The current study was to evaluate the association of Lipoprotein (a) [Lp(a)] and in-hospital outcomes in patients with acute coronary syndrome (ACS) undergoing percutaneous coronary intervention (PCI). : ACS patients undergoing PCI were retrospectively enrolled. Based on Lp(a) level, patients were divided into low (<30 mg/dL) and high (≥30 mg/dL) Lp(a) groups. : Compared to those with low Lp(a), patients with high Lp(a) had larger numbers of coronary arteries ≥70% stenosis and had longer coronary artery lesion (P < 0.05). After adjustment for covariates, high Lp(a) remained associated with higher odds of having coronary artery ≥70% stenosis, type C coronary lesion and pre-PCI TIMI flow grade 1/0. Patients with high Lp(a) had a higher unadjusted odds of acute stent thrombosis (odds ratio [OR] 1.10 and 95% confidence interval [CI] 1.01-2.27), congestive heart failure (OR 1.24 and 95% CI 1.15-2.38) and composite in-hospital outcomes (OR 1.28 and 95% CI 1.18-2.42). After adjustment for covariates, patients with high Lp(a) still had a higher odds of congestive heart failure (OR 1.08 and 95% CI 1.01-1.78) and composite in-hospital outcomes (OR 1.12 and 95% CI 1.04-1.81). : In ACS patients undergoing PCI, compared to those with low Lp(a), patients with high Lp(a) had more severe coronary artery lesion, higher risk of congestive heart failure and composite in-hospital outcomes.
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http://dx.doi.org/10.1080/00325481.2020.1845517DOI Listing
November 2020