Publications by authors named "Hanyu Wang"

89 Publications

The adsorption-desorption characteristics and degradation kinetics of ceftiofur in different agricultural soils.

Ecotoxicol Environ Saf 2021 Jul 14;222:112503. Epub 2021 Jul 14.

National Reference Laboratory of Veterinary Drug Residues (HZAU) and MOA Key Laboratory for Detection of Veterinary Drug Residues, Huazhong Agricultural University, Wuhan, Hubei 430070, China; MOA Laboratory for Risk Assessment of Quality and Safety of Livestock and Poultry Products, Hubei 430070, China; National Laboratory for Veterinary Drug Safety Evaluation, Huazhong Agriculture University, Wuhan 430070, China; College of Veterinary Medicine, Huazhong Agriculture University, Wuhan 430070, China. Electronic address:

Cephalosporins are one of the most widely used antibiotics. When cephalosporins are discharged into the environment, they not only induce the production of antibiotic resistant genes (ARGs) and antibiotic resistant bacteria (ARBs) but also cause toxic effects on animals and plants. Due to their complicated environmental behavior and lack of relevant data, the environmental behavior remains unclear. In this study, the adsorption-desorption and degradation characteristics of the third-generation cephalosporin drug ceftiofur (CEF) were investigated in three agricultural soils (sandy loam, loam and clay). According to the relevant parameters of the Freundlich adsorption isotherm (the K range was 57.63-122.44 μg L kg), CEF was adsorbed moderately in the soils and had the potential to migrate into groundwater. CEF exhibited low persistence in the soils and faster degradation than other antibiotics, such as tetracyclines and fluoroquinolones. The degradation half-lives (DT50) of CEF in soils ranged from 0.76 days to 4.31 days. Adding feces, increasing the water content, providing light and increasing the temperature significantly accelerated the degradation of CEF in soils. The DT50 values of CEF in soils were significantly prolonged when the soils were sterilized, indicating that both physical degradation and biodegradation played important roles in the degradation of CEF in soils. The DT50 values of CEF in soils were significantly prolonged at high concentrations, indicating that the degradability of CEF in soils was affected by the initial concentration. No significant differences were observed in the DT50 values for the different soil types (p > 0.05). This study provides useful information about the environmental behavior of CEF and improves the environmental risk assessment of CEF.
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http://dx.doi.org/10.1016/j.ecoenv.2021.112503DOI Listing
July 2021

Photo aging of polypropylene microplastics in estuary water and coastal seawater: Important role of chlorine ion.

Water Res 2021 Jul 1;202:117396. Epub 2021 Jul 1.

State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, Nanjing 210093, China. Electronic address:

Photo aging of microplastics (MPs) in water environment are relevant to free radical associated polymer chain reaction, and various photo chemical reactive constitutes (i.e., Cl, Br, NO, CO, and natural organic matters) would affect the reaction, leading to a great difference in the photo aging mechanism of MPs between freshwater and seawater system. This study investigated light induced photo aging process of polypropylene (PP) MPs in ultrapure water, estuary water, and seawater. Results revealed that the aging rate of PP MPs was significantly decreased in estuary water and seawater compared with that in ultrapure water, leading to a longer resistance time after emission in marine environment. Besides, lower carbonyl index was found with the increased aqueous Cl concentration, highlighting the important role of Cl in the inhibitory effect for PP MPs aging process in seawater. This is due to the formation of Cl in seawater which could react with HO• and prevent the formation of O, thus inhibit the photo aging process of PP MPs under light irradiation. The finding in this study clearly indicates the impact of the water matrices on the photo aging rate of MPs in natural water.
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http://dx.doi.org/10.1016/j.watres.2021.117396DOI Listing
July 2021

Maternal depression and loss of children under the one-child family planning policy in China: a cross-sectional study of 300 000 women.

BMJ Open 2021 Jul 9;11(7):e048554. Epub 2021 Jul 9.

Vanke School of Public Health, Tsinghua University, Beijing, China

Objectives: This study aims to explore the association between maternal depression and the loss of the only child under the family-planning (FP) policy.

Design: Cross-sectional data from a Chinese population-based study were analysed.

Setting: Population from 10 (5 rural and 5 urban) areas in China.

Participants: Around 300 000 females were included in the study. The FP group was defined as women with one or two live births. Those with no surviving child were classified into the loss-of-only-child group. The non-FP group included women who had more than two live births. Logistic regression was used to assess the relationship between major depressive disorder (MDD) and family types, after stratification and adjustment.

Outcome: MDD was assessed using the Composite International Diagnostic Inventory.

Results: The odds of MDD are 1.42 times higher in the FP group in general (OR=1.42, 95% CI: 1.28 to 1.57), as opposed to the non-FP group. In particular, the odds of MDD are 1.36 times greater in the non-loss-of-only-child group (OR=1.36, 95% CI: 1.21 to 1.51) and 2.80 (OR=2.80, 95% CI: 0.88 to 8.94) times greater in the loss-of-only-child group, compared with the non-FP group. The associations between FP groups and MDD appeared to be stronger in the elderly population, in those who were married, less educated and those with a higher household income. The association was found progressively stronger in those who lost their only child.

Conclusions: People in the FP group, especially those who lost their only child, are more susceptible to MDD than their counterparts in the non-FP group. Mental health programmes should give special care to those who lost their only child and take existing social policies and norms, such as FP policies, into consideration.
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http://dx.doi.org/10.1136/bmjopen-2020-048554DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8273468PMC
July 2021

Development of a magnetic MOF-based M-D-μSPE methodology combined with LC-MS/MS for the determination of fluorotelomer alcohols and its metabolites in animal derived foods.

Food Chem 2021 Jun 2;363:130205. Epub 2021 Jun 2.

National Reference Laboratory of Veterinary Drug Residues (HZAU) and MAO Key Laboratory for Detection of Veterinary Drug Residues, China; MOA Laboratory for Risk Assessment of Quality and Safety of Livestock and Poultry Products, China; Hubei Collaborative Innovation Center for Animal Nutrition and Feed Safety, Huazhong Agricultural University, Wuhan, Hubei 430070, China. Electronic address:

In this study, a novel modified metal organic framework (MOF) was prepared and used as adsorbent of miniaturized solid-phase extraction (M-D-μSPE) for analyzing 8-2 FTOH and its metabolites in edible tissues by LC-MS/MS. This synthesized adsorbent, named as [email protected] 101-NH (magnetic Fe-MOF), was characterized. Moreover, the effects factors on the adsorption behavior of the adsorbents for the analytes were investigated and optimized in detail, such as solution pH, adsorbent amount, extraction time, desorption condition. The adsorbtion mechanism of magnetic Fe-MOF might be electrostatic interaction, CF-π hydrophobic and Lewis acid base. Compared with conventional adsorbents (such as PSA, C18), magnetic Fe-MOF reduced matrix effect. The limits of quantification ranged 0.10-1.5 µg/kg. The recoveries of analytes ranged 78.0% - 90.3% in spiked samples, with relative standard deviations less than 12.0%. The developed method was successfully utilized to analyze incurred samples, which proves that it is a rapid, efficient, and sensitive method.
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http://dx.doi.org/10.1016/j.foodchem.2021.130205DOI Listing
June 2021

The Efficacy of High-Dose Dexamethasone vs. Other Treatments for Newly Diagnosed Immune Thrombocytopenia: A Meta-Analysis.

Front Med (Lausanne) 2021 25;8:656792. Epub 2021 May 25.

Fujian Provincial Key Laboratory on Hematology, Fujian Institute of Hematology, Fujian Medical University Union Hospital, Fuzhou, China.

To compare the therapeutic efficacies of high dose dexamethasone, prednisone and rituximab in combination with dexamethasone for newly diagnosed ITP (Immune Thrombocytopenia, ITP) patients. Relevant publications for this study were obtained by searching PubMed, Embase, Cochrane, and CNKI (National Knowledge Infrastructure, CNKI) databases following the PRISMA guidelines. A total of, 15 publications were retrieved that contained sufficient data from 1,362 patients for high quality analysis of this study endpoints. Data analysis was carried out using Stata 11.0 software. The primary outcomes were OR (Overall Response, OR) at 1 month after intervention and SR at 6 and 12 months. The secondary outcomes were AEs and relapse. There were no differences in the OR, while the SR was higher at 6 months ( = 0.001) as well as 12 months ( < 0.001) in the rituximab + dexamethasone group. In addition, the incidences of AEs ( = 0.008) were also higher in the rituximab + dexamethasone group. Dexamethasone was superior to prednisone based on OR ( = 0.006). We found no differences in SR at 6 months between dexamethasone and prednisone but SR at 12 months was higher in the dexamethasone group ( = 0.014). The relapse rate was higher in the high dose dexamethasone group compared to the rituximab + dexamethasone group ( = 0.042). This demonstrated that new treatment options such as Rituximab + dexamethasone, could be a good alternative to traditional therapy in improving long-term response and reducing the rate of relapse. However, further studies are required on the increased risk of AEs associated with Rituximab + dexamethasone.
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http://dx.doi.org/10.3389/fmed.2021.656792DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8185030PMC
May 2021

An Intelligent Self-Service Vending System for Smart Retail.

Sensors (Basel) 2021 May 20;21(10). Epub 2021 May 20.

Department of Electrical Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China.

The traditional weighing and selling process of non-barcode items requires manual service, which not only consumes manpower and material resources but is also more prone to errors or omissions of data. This paper proposes an intelligent self-service vending system embedded with a single camera to detect multiple products in real-time performance without any labels, and the system realizes the integration of weighing, identification, and online settlement in the process of non-barcode items. The system includes a self-service vending device and a multi-device data management platform. The flexible configuration of the structure gives the system the possibility of identifying fruits from multiple angles. The height of the system can be adjusted to provide self-service for people of different heights; then, deep learning skill is applied implementing product detection, and real-time multi-object detection technology is utilized in the image-based checkout system. In addition, on the multi-device data management platform, the information docking between embedded devices, WeChat applets, Alipay, and the database platform can be implemented. We conducted experiments to verify the accuracy of the measurement. The experimental results demonstrate that the correlation coefficient R2 between the measured value of the weight and the actual value is 0.99, and the accuracy of non-barcode item prediction is 93.73%. In Yangpu District, Shanghai, a comprehensive application scenario experiment was also conducted, proving that our system can effectively deal with the challenges of various sales situations.
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http://dx.doi.org/10.3390/s21103560DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8161222PMC
May 2021

Maternal Health-Seeking Behavior and Associated Factors in the Democratic Republic of the Congo.

Health Educ Behav 2021 May 21:10901981211010438. Epub 2021 May 21.

Vanke School of Public Health, Tsinghua University, Beijing, China.

Maternal health-seeking behavior (MHSB) is crucial for maternal health. However, little is known about MHSB in the Democratic Republic of the Congo (DRC). This study aims to evaluate the situation and socioeconomic associates of MHSB in the DRC. Based on the responses of 8,360 participants in a nationally representative survey, we adopted a K-modes cluster analysis algorithm to categorize women into three groups (i.e., infrequent service-users, partial service-users, and full service-users) according to their recent MHSB. Multinomial logistic regression was applied to identify the associated predictors of MHSB. The results show that most women (90.29%) did not receive integral maternal health services, including antenatal care, institutional delivery, and postnatal care. Compared with their counterparts, women who received higher maternal educational attainment, had good HIV-related knowledge, lived in urban regions, and lived in wealthier households were more likely to be partial service-users or full service-users. Women exposed to mass media at least once a week were more likely to be full service-users rather than infrequent service-users. The majority of participants who lived in Kasai and near provinces were infrequent service-users, indicating poor MHSB status in the region. Interventions to promote maternal health knowledge and awareness are highly recommended to improve MHSB in the DRC.
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http://dx.doi.org/10.1177/10901981211010438DOI Listing
May 2021

Transcriptional Profiling of on Galactose and Metabolic Engineering for Improved Galactose Utilization.

Front Microbiol 2021 28;12:664011. Epub 2021 Apr 28.

National Technology Innovation Center of Synthetic Biology, Tianjin, China.

Efficient biological conversion of all sugars from lignocellulosic biomass is necessary for the cost-effective production of biofuels and commodity chemicals. Galactose is one of the most abundant sugar in many hemicelluloses, and it will be important to capture this carbon for an efficient bioconversion process of plant biomass. Thermophilic fungus has been used as a cell factory to produce biochemicals directly from renewable polysaccharides. In this study, we draw out the two native galactose utilization pathways, including the Leloir pathway and oxido-reductive pathway, and identify the significance and contribution of them, through transcriptional profiling analysis of and its mutants on galactose. We find that galactokinase was necessary for galactose transporter expression, and disruption of resulted in decreased galactose utilization. Through metabolic engineering, both galactokinase deletion and galactose transporter overexpression can activate internal the oxido-reductive pathway and improve the consumption rate of galactose. Finally, the heterologous galactose-degradation pathway, De Ley-Doudoroff (DLD) pathway, was successfully integrated into , and the consumption rate of galactose in the engineered strain was increased by 57%. Our study focuses on metabolic engineering for accelerating galactose utilization in a thermophilic fungus that will be beneficial for the rational design of fungal strains to produce biofuels and biochemicals from a variety of feedstocks with abundant galactose.
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http://dx.doi.org/10.3389/fmicb.2021.664011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8113861PMC
April 2021

Automatic design of a mid-wavelength infrared dual-conjugate zoom system based on particle swarm optimization.

Opt Express 2021 May;29(10):14868-14882

This paper presents a method for the automatic design of a special mid-wavelength infrared zoom system in which the positions of both the pupil planes and the image plane are fixed during the zooming process. In this method, the formulas for the desired zoom system are derived to ensure the exact fulfillment of the conditions with three moving components based on Gaussian reduction. A mathematical model is established based on the particle swarm optimization to determine the first-order parameters of the paraxial design. Then, the model is optimized by iteratively updating a candidate solution with regard to a specific merit function that characterizes the zoom ratio, compactness, and aberration terms. In the optimization phase, the physical feasibility is considered as the constraint on the candidate solutions. Using two examples, this work demonstrates that the developed method is an efficient and practical tool for finding a realizable initial configuration of a dual-conjugate zoom system. Since this method is no longer reliant on the traditional trial-and-error technique, it is an important step toward the automatic design of complex optical systems using artificial intelligence.
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http://dx.doi.org/10.1364/OE.418584DOI Listing
May 2021

Gate-tunable chiral phonons in low-buckled group-IVA monolayers.

J Phys Condens Matter 2021 Jun 3;33(28). Epub 2021 Jun 3.

School of Physics and Technology, Nanjing Normal University, Nanjing 210023, People's Republic of China.

We investigate the electric response of chiral phonons on the low-buckled group-IVA monolayers by performing first-principles calculations. The vertical electric field breaks the degeneracy of phonon modes at high-symmetry ±points of the phonon Brillouin zone, and the size of the phononic gap is proportional to the strength of the electric field. The gapped phonon modes at ±possess chiralities with considerable phonon circular polarizations and discrete phonon pseudoangular momenta. The chiralities of phonons are robust against the variation of the field strength, but reversed by changing the field direction. Electric control of chiral phonons adds a new dimension to the study of chiral phonons, which has potential use in the design of phononic and valley devices.
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http://dx.doi.org/10.1088/1361-648X/abfee5DOI Listing
June 2021

Simulation of natural aging property of microplastics in Yangtze River water samples via a rooftop exposure protocol.

Sci Total Environ 2021 Sep 23;785:147265. Epub 2021 Apr 23.

State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, Nanjing 210093, China. Electronic address:

Due to low aging rate, the environmental behavior of naturally weathered microplastics (MPs) are not fully understood. Here, we systematically investigated the surface property and adsorption behavior of polypropylene (PP), polyethylene (PE) and polystyrene (PS) MPs during outdoor exposure in Yangtze River water for 18 months, and compared their difference from those in laboratory process. Results showed that compared to PE and PS MPs, PP underwent higher changes in surface aging properties such as rapid fragmentation and surface oxidation. Outdoor exposure exhibited different effects on adsorption property of MPs for metal ions, where adsorption capacities of PE and PS MPs for Co(II) were increased with aging degrees, while few change occurred on different aged PP MPs. As for Cr(VI), aging process further decreased the overall adsorption on PP, PE and PS MPs. The difference was mainly ascribed to the surface property (e.g. oxygen-containing groups and size) and the adhered biofilm and charged minerals. We further validated that similar types of oxidation products were formed between natural and laboratory aging of MPs, whereas the reaction order of these products, fragmentation rate and the change in adsorption property of aged MPs might be different in both processes. The findings provide essential information to assess real environmental behavior of MP samples.
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http://dx.doi.org/10.1016/j.scitotenv.2021.147265DOI Listing
September 2021

Enhanced Metal-Insulator Transition in Freestanding VO Down to 5 nm Thickness.

ACS Appl Mater Interfaces 2021 Apr 1;13(14):16688-16693. Epub 2021 Apr 1.

Division of Physics and Applied Physics, School of Physical and Mathematical Sciences, Nanyang Technological University, 21 Nanyang Link, 637371, Singapore.

Ultrathin freestanding membranes with a pronounced metal-insulator transition (MIT) have huge potential for future flexible electronic applications as well as provide a unique aspect for the study of lattice-electron interplay. However, the reduction of the thickness to an ultrathin region (a few nm) is typically detrimental to the MIT in epitaxial films, and even catastrophic for their freestanding form. Here, we report an enhanced MIT in VO-based freestanding membranes, with a lateral size up to millimeters and the VO thickness down to 5 nm. The VO membranes were detached by dissolving a SrAlO sacrificial layer between the VO thin film and the -AlO(0001) substrate, allowing the transfer onto arbitrary surfaces. Furthermore, the MIT in the VO membrane was greatly enhanced by inserting an intermediate AlO buffer layer. In comparison with the best available ultrathin VO membranes, the enhancement of MIT is over 400% at a 5 nm VO thickness and more than 1 order of magnitude for VO above 10 nm. Our study widens the spectrum of functionality in ultrathin and large-scale membranes and enables the potential integration of MIT into flexible electronics and photonics.
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http://dx.doi.org/10.1021/acsami.1c01581DOI Listing
April 2021

Review of the artificially-accelerated aging technology and ecological risk of microplastics.

Sci Total Environ 2021 May 30;768:144969. Epub 2021 Jan 30.

State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, Nanjing 210093, China. Electronic address:

After being discarded into the environment, the microplastics (MPs) will undergo weathering effects. However, the low degradation rate of MPs in natural processes greatly limits the understanding of long-term aging behavior. By critically reviewing 82 articles in Web of Science from 2015 to 2020, the paper summarized different laboratory technologies including light irradiation, chemical oxidation, heat treatment and γ-ray irradiation to simulate and accelerate the aging of MPs, and evaluated the feasibility by comparison with natural processes. The advantages of laboratory technologies are that aging conditions can be artificially controlled and that the labor and time costs can be saved, whereas the laboratory system is too simple to simulate complex aging processes in the environment. We further reviewed the potential impacts of aging process on the risks of MPs (i.e. physical injury, combined toxicity with external pollutants and chemical risk of additives and low-molecular products). The overall risks are seemingly enhanced by aging process due to the high ingestion by organisms, the strong interaction with pollutants and the release of MP-derived organic compounds. Further studies on the aging behavior of MPs should be focused on the laboratory techniques that can simulate multiple processes of natural aging, the long-term fragmentation behavior of MPs, the effect of aging on growth rate of biofilm in MPs and ingestion property by organisms, and the relationship between aging property of MPs and release rate of chemicals in leachates.
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http://dx.doi.org/10.1016/j.scitotenv.2021.144969DOI Listing
May 2021

Contralateral Lower Neck Sparing Radiotherapy in Stage N1 Nasopharyngeal Carcinoma: Long-Term Survival Outcomes and Late Toxicities.

Front Oncol 2021 25;11:628919. Epub 2021 Feb 25.

Department of Radiation Oncology, Sun Yat-sen University Cancer Center, Guangzhou, China.

Purpose: To explore the feasibility of contralateral lower neck sparing radiotherapy for patients with stage N1 nasopharyngeal carcinoma (NPC) by analyzing long-term survival outcomes and late toxicities.

Methods: Data of patients with stage N1 NPC who were treated with contralateral lower neck sparing radiotherapy between January 2013 and December 2015 were analyzed. These patients were all staged by magnetic resonance imaging (MRI), and all received irradiation to the upper neck (levels II, III, and Va) bilaterally along with ipsilateral levels IV and Vb, without irradiation of the contralateral lower neck. Treatment outcomes, regional failure patterns, and late toxicities were examined.

Results: A total of 275 eligible patients with stage N1 NPC were included in the present study. The median follow-up period was 62 months (range, 3-93 months). The 5-year overall survival (OS), distant metastasis-free survival (DMFS), local recurrence-free survival (LRFS), regional recurrence-free survival (RRFS), locoregional recurrence-free survival (LRRFS), and progression-free survival (PFS) rates were 90.5, 91.3, 94.7, 95.3, 91.2, and 81.7%, respectively. A total of 13 patients (4.7%) developed regional recurrence, all of which occurred in the field and not out of the field. Among 254 patients with available data on late toxicities, the most common late toxicity was xerostomia. No late injuries occurred in the carotid arteries, brachial plexus, or spinal cord. In addition to one case (0.4%) of neck fibrosis and three cases (1.2%) of hearing loss, there were no other grade 3-4 late toxicities observed.

Conclusions: Contralateral lower neck sparing radiotherapy would be safe and feasible for patients with stage N1 NPC, with the potential to improve the long-term quality of life of patients.
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http://dx.doi.org/10.3389/fonc.2021.628919DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7947858PMC
February 2021

Insight into chain scission and release profiles from photodegradation of polycarbonate microplastics.

Water Res 2021 May 26;195:116980. Epub 2021 Feb 26.

State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, Nanjing, Jiangsu 210093, People's Republic of China. Electronic address:

Bisphenol A polycarbonate (BPA-PC) is a kind of widely used engineering plastics. However, excessive usage causes the production of plastic wastes, following property changes of polymers and high risks of released chemicals during outdoor weathering. In this study, we systematically investigated the photoaging behavior of PC microplastics (MPs) in aquatic environment and evaluated the potential risk of released intermediates. Light irradiation along with mechanical abrasion facilitated the fragmentation of PC MPs and stimulated photooxidative modification during 640 h of ultraviolet (UV) exposure. Continuous degradation of the polymer was accompanied with dramatic decline of molecular weight. Also, BPA was released from irradiated PC MPs with a trend of an initial rapid increase followed by a decrease versus the irradiation time, and the maximum concentration of dropped BPA was detected up to 652.80 ± 72.89 μg/g (43.39% and 56.61% respectively in particles and leachates). However, the releasing amount of BPA in the leachate merely occupied 2.7% of the total organic carbon (TOC) leached out, suggesting that a great number of unknown organic products were produced other than BPA. Liquid chromatography-time-of-flight-mass spectrometry (LC-TOF-MS) analysis showed that these organic compounds forming MPs-derived dissolved organic matter (MPs DOM) were partly composed of 4,4'-dihydroxybenzophenone (DHB), p-hydroxybenzoic acid (p-HBA) and methyparaben (MeP), which would also contribute to the estrogenic activity. The degradation pathway of PC MPs was elaborated with the photolysis process of PC dimer and BPA, and the remarkable photoaging of PC MPs was mainly dominated by the generated reactive oxygen species (ROS). The findings of this study indicated that understanding the photoaging process of PC MPs was vital to evaluate their integral cumulative estrogenic activity in aquatic environment, and further highlighted the notable possible risks of plastic leachates to exposed biota.
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http://dx.doi.org/10.1016/j.watres.2021.116980DOI Listing
May 2021

Association between Urinary Iodine Concentration and Thyroid Nodules in Adults: A Cross-Sectional Study in China.

Biomed Res Int 2020 17;2020:4138657. Epub 2020 Dec 17.

Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.

Background: Associations between iodine intake and thyroid nodules (TNs) were not consistent. We aimed to illustrate the relationship between urinary iodine concentration (UIC) and TNs.

Methods: A total of 12,698 participants were enrolled in analysis. All of the participants filled out questionnaires and underwent physical examinations, laboratory tests, and thyroid ultrasonography. UIC, serum thyrotropin (TSH), thyroid peroxidase antibodies (TPOAb), and thyroglobulin antibodies (TgAb) were measured in the central laboratory.

Results: The prevalence of TNs was 16.00%, and the median UIC was 206.1 g/L. TNs and UIC were negatively related when UIC was less than 527 g/L (adjusted OR = 0.87; 95% CI, 0.80, 0.94), and the relationship between UIC and TNs was not statistically significant when UIC was greater than 527 g/L (adjusted OR = 1.25; 95% CI, 0.98, 1.60). In women, UIC was negatively associated with risk for TNs (adjusted OR 0.95; 95% CI, 0.91, 0.99).

Conclusion: The relationship between TNs and UIC differed between men and women. The risk of TNs decreased with the elevation of UIC in men when UIC was lower than 527 g/L, while UIC and the presence of TNs were negatively correlated in women. In the future, cohort studies or other studies that can explain causality must be conducted to explore the relationship between iodine status and TNs.
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http://dx.doi.org/10.1155/2020/4138657DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7762642PMC
May 2021

Enhanced phototransformation of atorvastatin by polystyrene microplastics: Critical role of aging.

J Hazard Mater 2021 04 10;408:124756. Epub 2020 Dec 10.

State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, Nanjing, Jiangsu 210093, People's Republic of China. Electronic address:

Reactive oxygen species (ROS) generated from light irradiation of microplastics (MPs) can potentially affect the environmental fate of organic contaminants when they coexist in the same environment. This study investigated the effect of polystyrene (PS) MPs with different aging degrees on the phototransformation of atorvastatin (ATV) under simulated sunlight. Results showed that the presence of PS MPs facilitated the phototransformation of ATV, and the degradation rate was linearly correlated with the aging degree (i.e., carbonyl index) of MPs. The enhanced effects mainly depended on the contents of oxygen-containing functional groups of PS MPs, which increased the absorption of light energy and the generation of ROS (e.g., singlet oxygen (O) and triplet-excited state PS (PS*)). Quenching experiments indicated that O generated from photosensitization of PS was the major contributor to the increased phototransformation of ATV. Additionally, the role of PS* became more important in the photodegradation mediated by higher degree aged MPs because much more O was generated from the PS* . PS MPs also increased the types and yields of degradation products, especially for higher degree aged MPs, despite the low effect on leachate toxicity. The findings provide a novel insight into the critical role of MPs in the fate of organic contaminants in aquatic environments.
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http://dx.doi.org/10.1016/j.jhazmat.2020.124756DOI Listing
April 2021

A method for screening tigecycline-resistant gene tet(X) from human gut.

J Glob Antimicrob Resist 2021 03 26;24:29-31. Epub 2020 Nov 26.

Department of Clinical Laboratory, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China. Electronic address:

Objectives: To develop an effective enrichment method for tet(X) detection, we performed PCR and Sanger sequencing to screen and confirm the presence of tet(X) gene.

Methods: Species were identified by MALDI-TOF MS analysis. The minimum inhibitory concentrations (MICs) of common antibiotics were determined by broth microdilution and interpreted according to the CLSI guidelines and EUCAST breakpoints.

Results: We obtained 29 (2.26%, 29/1284) tet(X4)-positive Escherichia coli, and 96.6% of those (28 isolates) exhibited resistance to tigecycline.

Conclusion: This specific screening strategy for functional tet(X) mediating tigecycline resistance will be useful to facilitate development and advancement of our knowledge of tet(X).
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http://dx.doi.org/10.1016/j.jgar.2020.11.010DOI Listing
March 2021

Factors that predict the technical difficulty during endoscopic full-thickness resection of a gastric submucosal tumor.

Rev Esp Enferm Dig 2021 Jan;113(1):35-40

Gastroenterology, The Second Xiangya Hospital of Central South Unive, China.

Background And Aim: endoscopic full-thickness resection (EFTR) is widely accepted for the treatment of gastric submucosal tumors (SMTs). However, technical difficulties sometimes occur. The aim of the present study was to assess the safety and efficacy of EFTR for gastric SMTs and to explore risk factors for technical difficulty.

Methods: the clinical data of patients who received EFTR for gastric SMTs was retrospectively collected from April 2011 to September 2019. Efficacy was defined as an en bloc resection. Difficult EFTR was defined as a procedure time ≥ 120 minutes and/or the occurrence of major adverse events, such as major bleeding, abdominal pain or peritonitis. Finally, risk factors for technical difficulty of EFTR such as gender, age, tumor location, size, symptomatic, regular, outgrowth, operator experience and pathology were analyzed in a univariate and multivariate analysis.

Results: one hundred SMTs were removed by EFTR. The average surgery time was 75.73 ± 45.9 (range: 20-250) minutes and the average tumor size was 16.23 ± 7.73 (range: 6-40) mm. With regard to efficacy, en bloc resection was achieved in 98 cases (98 %). A total of ten patients (9.9 %) had complications, namely two intra-operative bleeding, one delayed bleeding and seven patients had abdominal pain (overt peritonitis). EFTR was ceased in one patient due to massive intra-operative bleeding and conversion to laparoscopic surgery was necessary. One patient required laparoscopic surgery due to delayed bleeding, and other complications were resolved with a conservative treatment. A total of 18 cases (17.8 %) encountered a difficult EFTR: tumor size ≥ 3 cm (p = 0.008) and location at the gastric corpus (p = 0.007) were risk factors for a difficult EFTR according to the logistic analysis.

Conclusion: EFTR is safe and effective for the treatment of gastric SMTs. Tumor size of ≥ 3 cm and location at the gastric corpus are risk factors for a difficult EFTR.
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http://dx.doi.org/10.17235/reed.2020.7040/2020DOI Listing
January 2021

Preparation of PbS NPs/RGO/NiO nanosheet arrays heterostructure: Function-switchable self-powered photoelectrochemical biosensor for HO and glucose monitoring.

Biosens Bioelectron 2020 Nov 7;173:112803. Epub 2020 Nov 7.

Collaborative Innovation Center for Green Chemical Manufacturing and Accurate Detection, School of Chemistry and Chemical Engineering, University of Jinan, Jinan, 250022, PR China; Key Laboratory of Interfacial Reaction & Sensing Analysis in Universities of Shandong, School of Chemistry and Chemical Engineering, University of Jinan, Jinan, 250022, PR China.

On the basis of synthesized PbS nanoparticles (PbS NPs)/reduced graphene oxide (RGO)/NiO nanosheet arrays (NiO NSAs) heterostructure, we constructed a function-switchable self-powered PEC sensing platform for the analysis of HO and glucose. Ordered NiO NSAs have high electron mobility, modifying RGO onto the surfaces of NiO NSAs can connect the NiO NSAs with the PbS NPs and promoted the electron transfer rate between them, as well as enhance their photocurrent response. The PbS NPs/RGO/NiO NSAs heterostructure own excellent catalase-like activity can achieve HO detection, only with one more step, after introducing glucose oxidase (GOD) onto the surface of PbS NPs/RGO/NiO NSAs heterostructure, we realized the detection conversion between HO and glucose. Under optimal conditions, the proposed biosensor exhibited superior analytical performance toward HO and glucose, a limit of detection (LOD) of 0.018 mM (S/N = 3) and 5.3 × 10 M (S/N = 3) were obtained, respectively. Moreover, good accuracy was obtained in the real samples analysis of HO disinfectant and human serum samples.
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http://dx.doi.org/10.1016/j.bios.2020.112803DOI Listing
November 2020

Critical effect of iron red pigment on photoaging behavior of polypropylene microplastics in artificial seawater.

J Hazard Mater 2021 02 8;404(Pt B):124209. Epub 2020 Oct 8.

State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, Nanjing 210093, China. Electronic address:

Microplastics (MPs) containing chemical additives undergo extensive aging in the environment, but the effect of additives on aging behavior of MPs is not fully understood. This study evaluated the effects of iron red pigment on the photoaging behavior of polypropylene (PP) MPs and the release kinetics of Fe(II) and Fe(III) under simulated sunlight. Based on analyses in surface property and aging products of leachate, the incorporated iron red pigment significantly decreased the photoaging rate of PP MPs. The critical effect mainly depended on the light shielding and the competition of pigment for electrons and reactive oxygen species generated from irradiated MPs. Light irradiation also caused the production of homologous series of organic products containing dicarboxylic acid end groups. Moreover, aging of pigmented MPs enhanced the release of Fe ions in leachates, and the types of released iron ions were different between dark and light conditions, where the iron ion in dark system was mainly as Fe(III), while Fe(II) was the dominant form in light irradiation, since the released Fe(III) reacted with MP-derived organic acids and reactive oxygen species in light condition. The findings highlight the critical role of inorganic pigments in the environmental fate and risk of MPs.
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http://dx.doi.org/10.1016/j.jhazmat.2020.124209DOI Listing
February 2021

Clinical characteristics and prognostic factors of COVID-19 patients progression to severe: a retrospective, observational study.

Aging (Albany NY) 2020 Oct 14;12(19):18853-18865. Epub 2020 Oct 14.

Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.

The outbreak of coronavirus disease 2019 (COVID-19) has become a world-wide emergency. The severity of COVID-19 is highly correlated with its mortality rate. We aimed to disclose the clinical characteristics and prognostic factors of COVID-19 patients who developed severe COVID-19. The study enrolled cases (no=1848) with mild or moderate type of COVID-19 in Fangcang shelter hospital of Jianghan. A total of 56 patients progressed from mild or moderate to severe. We used least absolute shrinkage and selection operator regression model to select prognostic factors for this model. The case-severity rate was 3.6% in the shelter hospital. They were all symptomatic at admission. Fever, cough, and fatigue were the most common symptoms. Hypertension, diabetes and coronary heart diseases were common co-morbidities. Predictors contained in the prediction nomogram included fever, distribution of peak temperature (>38°C), myalgia or arthralgia and distribution of C-reactive protein (≥10 mg per L). The distribution of peak temperature (>38°C) on set, myalgia or arthralgia and C-reactive protein (≥10 mg per L) were the prognostic factors to identify the progression of COVID-19 patients with mild or moderate type. Early attention to these risk factors will help alleviate the progress of the COVID-19.
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http://dx.doi.org/10.18632/aging.103931DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7732300PMC
October 2020

Photo aging and fragmentation of polypropylene food packaging materials in artificial seawater.

Water Res 2021 Jan 24;188:116456. Epub 2020 Sep 24.

State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, Nanjing 210093, China. Electronic address:

Plastic litters in marine environment usually contain varied types and contents of additives that can significantly affect the photochemical aging and fragmentation process of microplastics (MPs). This study investigated the photo aging process of two common polypropylene (PP) food packaging materials (i.e., meal box and tea cup) in artificial seawater within 12 d of ultraviolet (UV) irradiation. Results revealed that the aging of both plastic materials were critically inhibited compared with pure PP, indicating that PP food packaging materials in natural seawater may share longer aging time than pure ones. GC-MS analysis revealed that antioxidant Irgafos 168 (tris (2,4-di-tert-butylphenyl) phosphite) was the dominant additive in these plastic materials. Photo reaction between Irgafos 168 and hydroperoxide species on the surface of MPs to prevent the formation of hydroxyl radical was the possible mechanism for the inhibiting effects. After antioxidant was exhausted, its photo degradation products could become the dominant contributor to influence the aging process of MPs. This is the first work exploring the role of antioxidant on the aging process of PP MPs in simulated ocean environment. The findings could be of great help for unraveling the effect of antioxidants on the aging-related environmental risk of hydrocarbon plastics in ocean environment.
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http://dx.doi.org/10.1016/j.watres.2020.116456DOI Listing
January 2021

YMR152W from Saccharomyces cerevisiae encoding a novel aldehyde reductase for detoxification of aldehydes derived from lignocellulosic biomass.

J Biosci Bioeng 2021 Jan 20;131(1):39-46. Epub 2020 Sep 20.

Institute of Resources and Geographic Information Technology, College of Resources, Sichuan Agricultural University, Wenjiang, Chengdu, Sichuan 611130, PR China; Department of Applied Microbiology, College of Resources, Sichuan Agricultural University, Wenjiang, Chengdu, Sichuan 611130, PR China. Electronic address:

Aldehydes are the main inhibitors generated during the pretreatment of lignocellulosic biomass, which can inhibit cell growth and disturb subsequent fermentation. Saccharomyces cerevisiae has the intrinsic ability to in situ detoxify aldehydes to their less toxic or nontoxic alcohols by numerous aldehyde dehydrogenases/reductases during the lag phase. Herein, we report that an uncharacterized open reading frame YMR152W from S. cerevisiae encodes a novel aldehyde reductase with catalytic functions for reduction of at least six aldehydes, including two furan aldehydes (furfural and 5-hydroxymethylfurfural), three aliphatic aldehydes (acetaldehyde, glycolaldehyde, and 3-methylbutanal), and an aromatic aldehyde (benzaldehyde) with NADH or NADPH as the co-factor. Particularly, Ymr152wp displayed the highest specific activity (190.86 U/mg), and the best catalytic rate constant (K), catalytic efficiency (K/K), and affinity (K) when acetaldehyde was used as the substrate with NADH as the co-factor. The optimum pH of Ymr152wp is acidic (pH 5.0-6.0), but this enzyme is more stable in alkaline conditions (pH 8.0). Metal ions, chemical protective additives, salts, and substrates could stimulate or inhibit enzyme activities of Ymr152wp in varying degrees. Ymr152wp was classified into the quinone oxidoreductase (QOR) subfamily of the medium-chain dehydrogenase/reductase (MDR) family based on the results of amino acid sequence analysis and phylogenetic analysis. Although Ymr152wp was grouped into the QOR family, no quinone reductase activity was observed using typical quinones (9,10-phenanthrenequinone, 1,2-naphthoquinone, and p-benzoquinone) as the substrates. This study provides guidelines for exploring more uncharacterized aldehyde reductases in S. cerevisiae for in situ detoxification of aldehyde inhibitors derived from lignocellulosic hydrolysis.
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http://dx.doi.org/10.1016/j.jbiosc.2020.09.004DOI Listing
January 2021

The socioeconomic and lifestyle determinants of contraceptive use among Chinese college students: a cross-sectional study.

Reprod Health 2020 Aug 17;17(1):125. Epub 2020 Aug 17.

Vanke School of Public Health, Tsinghua University, Zhongguancun North Street, Haidian District, Beijing, 100084, China.

Background: Chinese youth have become more sexually active over the years, yet their behaviours of contraceptive use are influenced by socioeconomic and lifestyle factors. This study aimed to investigate the socioeconomic and lifestyle determinants of contraceptive use among Chinese college students, and to investigate quantitatively their reasons for choosing different contraceptive methods.

Methods: The study used the data from a cross-sectional survey, which was conducted in 2015 among 17,517 students from 130 colleges and professional schools in mainland China. Chi-square tests were performed to test the differences in the awareness and uses of contraceptives between male and female students. Multivariable logistic regression models were used to analyse the associations between socioeconomic and lifestyle factors and contraceptive uses.

Results: Condoms (95%), oral contraceptives (91%) and emergency contraceptives (71%) were the most commonly known contraceptive methods among the sample of Chinese youth that were surveyed. Among male participants, high monthly expenditure (OR = 1.37, 95%CI: 1.07-1.75), light alcohol consumption (OR = 1.47, 95%CI: 1.03-2.11), and high sexual knowledge (OR = 1.96, 95%CI: 1.57-2.45) were positively associated with contraceptive uses, while tobacco use (OR = 0.47, 95%CI: 0.23-0.95) showed a negative association with contraceptive uses. Among female students, suburban residency (OR = 1.38, 95%CI: 1.03-1.83), high level of parental education (OR = 1.96, 95%CI: 1.19-3.22), moderate alcohol consumption (OR = 2.66, 95%CI: 1.05-6.77), and high sexual knowledge (OR = 1.50, 95%CI: 1.18-1.91) were positively associated with contraceptive uses, while tobacco use (OR = 0.60, 95%CI: 0.36-0.99) showed a negative association.

Conclusions: A series of socioeconomic and lifestyle factors were associated with contraceptive choices among Chinese college students. Targeted sexual education programs are in demand to improve the awareness and the use of contraceptives in this population.
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http://dx.doi.org/10.1186/s12978-020-00978-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7433035PMC
August 2020

Impaired Fasting Glucose and Diabetes Are Related to Higher Risks of Complications and Mortality Among Patients With Coronavirus Disease 2019.

Front Endocrinol (Lausanne) 2020 10;11:525. Epub 2020 Jul 10.

Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Diabetes correlates with poor prognosis in patients with COVID-19, but very few studies have evaluated whether impaired fasting glucose (IFG) is also a risk factor for the poor outcomes of patients with COVID-19. Here we aimed to examine the associations between IFG and diabetes at admission with risks of complications and mortality among patients with COVID-19. In this multicenter retrospective cohort study, we enrolled 312 hospitalized patients with COVID-19 from 5 hospitals in Wuhan from Jan 1 to Mar 17, 2020. Clinical information, laboratory findings, complications, treatment regimens, and mortality status were collected. The associations between hyperglycemia and diabetes status at admission with primary composite end-point events (including mechanical ventilation, admission to intensive care unit, or death) were analyzed by Cox proportional hazards regression models. The median age of the patients was 57 years (interquartile range 38-66), and 172 (55%) were women. At the time of hospital admission, 84 (27%) had diabetes (and 36 were new-diagnosed), 62 (20%) had IFG, and 166 (53%) had normal fasting glucose (NFG) levels. Compared to patients with NFG, patients with IFG and diabetes developed more primary composite end-point events (9 [5%], 11 [18%], 26 [31%]), including receiving mechanical ventilation (5 [3%], 6 [10%], 21 [25%]), and death (4 [2%], 9 [15%], 20 [24%]). Multivariable Cox regression analyses showed diabetes was associated increased risks of primary composite end-point events (hazard ratio 3.53; 95% confidence interval 1.48-8.40) and mortality (6.25; 1.91-20.45), and IFG was associated with an increased risk of mortality (4.11; 1.15-14.74), after adjusting for age, sex, hospitals and comorbidities. IFG and diabetes at admission were associated with higher risks of adverse outcomes among patients with COVID-19.
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http://dx.doi.org/10.3389/fendo.2020.00525DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7365851PMC
August 2020

Detection and genetic characterization of the colistin resistance gene mcr-3.3 in an Aeromonas veronii strain isolated from alligator faeces.

J Glob Antimicrob Resist 2020 09 15;22:860-861. Epub 2020 Jul 15.

Centre of Laboratory Medicine, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, China. Electronic address:

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http://dx.doi.org/10.1016/j.jgar.2020.07.003DOI Listing
September 2020

New insights into two yeast BDHs from the PDH subfamily as aldehyde reductases in context of detoxification of lignocellulosic aldehyde inhibitors.

Appl Microbiol Biotechnol 2020 Aug 15;104(15):6679-6692. Epub 2020 Jun 15.

Institute of Resources and Geographic Information Technology, College of Resources, Sichuan Agricultural University, No. 211 Huimin Road, Wenjiang, Chengdu, 611130, Sichuan, People's Republic of China.

At least 24 aldehyde reductases from Saccharomyces cerevisiae have been characterized and most function in in situ detoxification of lignocellulosic aldehyde inhibitors, but none is classified into the polyol dehydrogenase (PDH) subfamily of the medium-chain dehydrogenase/reductase (MDR) superfamily. This study confirmed that two (2R,3R)-2,3-butanediol dehydrogenases (BDHs) from industrial (denoted Y)/laboratory (denoted B) strains of S. cerevisiae, Bdh1p(Y)/Bdh1p(B) and Bdh2p(Y)/Bdh2p(B), were members of the PDH subfamily with an NAD(P)H binding domain and a catalytic zinc binding domain, and exhibited reductive activities towards lignocellulosic aldehyde inhibitors, such as acetaldehyde, glycolaldehyde, and furfural. Especially, the highest enzyme activity towards acetaldehyde by Bdh2p(Y) was 117.95 U/mg with cofactor nicotinamide adenine dinucleotide reduced (NADH). Based on the comparative kinetic property analysis, Bdh2p(Y)/Bdh2p(B) possessed higher specific activity, substrate affinity, and catalytic efficiency towards glycolaldehyde than Bdh1p(Y)/Bdh1p(B). This was speculated to be related to their 49% sequence differences and five nonsynonymous substitutions (Ser41Thr, Glu173Gln, Ile270Leu, Ile316Met, and Gly317Cys) occurred in their conserved NAD(P)H binding domains. Compared with BDHs from a laboratory strain, Bdh1p(Y) and Bdh2p(Y) from an industrial strain displayed five nonsynonymous mutations (Thr, Asn, Glu, Val, and Ala) and three nonsynonymous mutations (Ala, Ile, and Ala), respectively. From a first analysis with selected aldehydes, their reductase activities were different from BDHs of laboratory strain, and their catalytic efficiency was higher towards glycolaldehyde and lower towards acetaldehyde. Comparative investigation of kinetic properties of BDHs from S. cerevisiae as aldehyde reductases provides a guideline for their practical applications in in situ detoxification of aldehyde inhibitors during lignocellulose bioconversion.Key Points• Two yeast BDHs have enzyme activities for reduction of aldehydes.• Overexpression of BDHs slightly improves yeast tolerance to acetaldehyde and glycolaldehyde.• Bdh1p and Bdh2p differ in enzyme kinetic properties.• BDHs from strains with different genetic backgrounds differ in enzyme kinetic properties.
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http://dx.doi.org/10.1007/s00253-020-10722-9DOI Listing
August 2020

The efficacy and safety of daunorubicin versus idarubicin combined with cytarabine for induction therapy in acute myeloid leukemia: A meta-analysis of randomized clinical trials.

Medicine (Baltimore) 2020 Jun;99(24):e20094

Fujian Institute of Hematology, Fujian Provincial Key Laboratory on Hematology, Fujian Medical University Union Hospital, Fuzhou, Fujian, China.

Objective: To ascertain the efficacy and safety of daunorubicin combined with cytarabine comparing with idarubicin combined with cytarabine as a standard induction therapy for acute Myeloid leukemia by a meta-analysis.

Methods: The randomized controlled trials included were retrieved from PubMed, Embase, and Cochrane library. We evaluated and cross-checked the randomized clinical trials (RCTs) comparing daunorubicin combined with cytarabine (DA) and idarubicin combined with cytarabine (IA) by two reviewers independently according to Cochrane Handbook for Systematic Reviewers of Interventions. The data of meta-analysis was conducted using Review Manager 5.3 and Stata 12.0 software.

Results: A total of 6 studies containing 3140 patients were included. The primary outcomes were complete remission (CR), CR in one course (CR1), CR in two courses (CR2), overall survival (OS), and relapse rate. The secondary outcomes included adverse events and cytogenetic risk in subgroup analyses. IA showed a statistically significant in CR (RR = 1.05; 95%CI = 1.00-1.09, P = .03) and CR1 (RR = 1.11; 95%CI = 1.04-1.18, P = .003), but not in CR2 (RR = 0.97; 95%CI = 0.77-1.24, P = .83), and relapse rate (RR = 1.08; 95%CI = 0.98-1.43, P = .08). In high dose daunorubicin group, OS was significantly improved with IA compared to DA (HR = 0.89, 95%CI = 0.8-1.0, P = .041, I = 0). At grade 3/4 adverse events, the difference between IA and DA was not statistically significant (infection, P = .28; cardiac toxicity, P = .15; bleeding, P = .29). In the subgroup analysis, the genotypes of the IA and DA groups were not statistically significant for comparison of CR between the two groups (P = .07).

Conclusion: This meta-analysis showed that IA had a better efficacy in the treatment of acute myeloid leukemia than DA, even with increased doses of DA. The OS of a standard dose of IA patients was longer than that of DA patients. Our research shows that anthracycline dose intensification of daunorubicin is of no clinically relevant benefit in AML patients comparing with a standard dose of IA. When it comes to adverse drug reactions, it is not a significant difference. Therefore, in clinical practice, IA should be the first choice for induction regimen in patients with acute myeloid leukemia.
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http://dx.doi.org/10.1097/MD.0000000000020094DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7302600PMC
June 2020

Regional economic development, household income, gender and hypertension: evidence from half a million Chinese.

BMC Public Health 2020 Jun 10;20(1):901. Epub 2020 Jun 10.

School of Public Health, Peking University Health Science Center, Beijing, China.

Background: Hypertension may be influenced by multiple factors, including social and individual determinants. Regional and individual economic disparity in China is closely associated with such factors that may give rise to diverse health outcomes. This study examines the relationship between regional economic development, household income, gender and hypertension prevalence in China.

Methods: This study utilized data from the China Kadoorie Biobank (CKB), a population-based study on half a million Chinese adults from 10 geographically distinct regions. Hypertension was identified by a measured systolic blood pressure/diastolic blood pressure ≥ 140/90 mmHg or receiving treatment. Regional economic development was inferred from GDP per capita at the time of the study. A logistic regression based method was used in calculating the prevalence of hypertension in different household income, regional economic development, and gender groups, adjusting for demographic, social-economic and lifestyle factors.

Results: The prevalence of hypertension was the lowest in the medium GDP per capita areas in both male (31.62, 95% CI: 31.26-31.98%) and female (22.85, 95% CI: 22.50-23.19%) as compared to that in the low GDP per capita regions (male: 32.75, 95% CI 32.41-33.08%; female: 32.12, 95% CI: 31.78-32.47%) and high GDP per capita areas (male: 39.74, 95% CI: 39.33-40.16%; female: 35.19, 95% CI: 34.74-35.65%). There was an inverse relationship between hypertension and household income in the low and high GDP areas and an U-shaped association in the medium GDP per capita areas. Higher hypertension prevalence was observed in males across all GDP per capita areas. The negative correlation between hypertension and household income (across all GDP per captia areas) was stronger in females than in males.

Conclusions: The present study underlined the important influence of regional economic development, household income and gender on hypertension. Interventions for hypertension prevention and management should take into consideration the influence of sex difference and socioeconomic disparities at both micro- and macro- levels, in addition to a person-centered approach.
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http://dx.doi.org/10.1186/s12889-020-09002-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7288507PMC
June 2020