Hansjuerg Alder

Hansjuerg Alder

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Hansjuerg Alder

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Human-like hyperplastic prostate with low ZIP1 induced solely by Zn deficiency in rats.

Authors:
Louise Y Fong Ruiyan Jing Karl J Smalley Zi-Xuan Wang Cristian Taccioli Sili Fan Hongping Chen Hansjuerg Alder Kay Huebner John L Farber Oliver Fiehn Carlo M Croce

Proc Natl Acad Sci U S A 2018 11 5;115(47):E11091-E11100. Epub 2018 Nov 5.

Department of Cancer Biology and Genetics, The Ohio State University, Columbus, OH 43210;

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http://www.pnas.org/lookup/doi/10.1073/pnas.1813956115
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http://dx.doi.org/10.1073/pnas.1813956115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6255182PMC
November 2018

MiR-34a/c-Dependent PDGFR-α/β Downregulation Inhibits Tumorigenesis and Enhances TRAIL-Induced Apoptosis in Lung Cancer.

Authors:
Michela Garofalo Young-Jun Jeon Gerard J Nuovo Justin Middleton Paola Secchiero Pooja Joshi Hansjuerg Alder Natalya Nazaryan Gianpiero Di Leva Giulia Romano Melissa Crawford Patrick Nana-Sinkam Carlo M Croce

PLoS One 2013 21;8(6):e67581. Epub 2013 Jun 21.

Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, the Ohio State University, Columbus, Ohio, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0067581PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3689725PMC
October 2017

Integration of metabolomics, transcriptomics, and microRNA expression profiling reveals a miR-143-HK2-glucose network underlying zinc-deficiency-associated esophageal neoplasia.

Authors:
Louise Y Fong Ruiyan Jing Karl J Smalley Cristian Taccioli Johannes Fahrmann Dinesh K Barupal Hansjuerg Alder John L Farber Oliver Fiehn Carlo M Croce

Oncotarget 2017 Oct 9;8(47):81910-81925. Epub 2017 Jun 9.

Department of Molecular Virology, Immunology, and Medical Genetics, Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA.

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http://dx.doi.org/10.18632/oncotarget.18434DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5669858PMC
October 2017

Downregulation of p53-inducible microRNAs 192, 194, and 215 Impairs the p53/MDM2 Autoregulatory Loop in Multiple Myeloma Development.

Authors:
Flavia Pichiorri Sung-Suk Suh Alberto Rocci Luciana De Luca Cristian Taccioli Ramasamy Santhanam Wenchao Zhou Don M Benson Craig Hofmainster Hansjuerg Alder Michela Garofalo Gianpiero Di Leva Stefano Volinia Huey-Jen Lin Danilo Perrotti Michael Kuehl Rami I Aqeilan Antonio Palumbo Carlo M Croce

Cancer Cell 2016 08 8;30(2):349-351. Epub 2016 Aug 8.

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http://dx.doi.org/10.1016/j.ccell.2016.07.007DOI Listing
August 2016

Correction: MiR-34a/c-Dependent PDGFR-α/β Downregulation Inhibits Tumorigenesis and Enhances TRAIL-Induced Apoptosis in Lung Cancer.

Authors:
Michela Garofalo Young-Jun Jeon Gerard J Nuovo Justin Middleton Paola Secchiero Pooja Joshi Hansjuerg Alder Natalya Nazaryan Gianpiero Di Leva Giulia Romano Melissa Crawford Patrick Nana-Sinkam Carlo M Croce

PLoS One 2015 25;10(6):e0131729. Epub 2015 Jun 25.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0131729PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4482494PMC
May 2016

A selective screening platform reveals unique global expression patterns of microRNAs in a cohort of human soft-tissue sarcomas.

Authors:
Peter Y Yu Mumtaz Y Balkhi Katherine J Ladner Hansjuerg Alder Lianbo Yu Xiaokui Mo William G Kraybill Denis C Guttridge O Hans Iwenofu

Lab Invest 2016 Apr 15;96(4):481-91. Epub 2016 Feb 15.

Arthur G. James Comprehensive Cancer Center, The Ohio State University Wexner Medical Center, Columbus, OH, USA.

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http://dx.doi.org/10.1038/labinvest.2015.168DOI Listing
April 2016

MicroRNA dysregulation and esophageal cancer development depend on the extent of zinc dietary deficiency.

Authors:
Louise Y Fong Cristian Taccioli Ruiyan Jing Karl J Smalley Hansjuerg Alder Yubao Jiang Paolo Fadda John L Farber Carlo M Croce

Oncotarget 2016 Mar;7(10):10723-38

Department of Molecular Virology, Immunology, and Medical Genetics, Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA.

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http://dx.doi.org/10.18632/oncotarget.7561DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905434PMC
March 2016

Repression of Esophageal Neoplasia and Inflammatory Signaling by Anti-miR-31 Delivery In Vivo.

Authors:
Cristian Taccioli Michela Garofalo Hongping Chen Yubao Jiang Guidantonio Malagoli Tagliazucchi Gianpiero Di Leva Hansjuerg Alder Paolo Fadda Justin Middleton Karl J Smalley Tommaso Selmi Srivatsava Naidu John L Farber Carlo M Croce Louise Y Fong

J Natl Cancer Inst 2015 Nov 18;107(11). Epub 2015 Aug 18.

Department of Molecular Virology, Immunology, and Medical Genetics, Comprehensive Cancer Center, The Ohio State University, Columbus, OH (CT, MG, GDL, HA, PF, JM, CMC); Kimmel Cancer Center (HC, YJ, KJS, LYF) and Department of Pathology, Anatomy, and Cell Biology (YJ, JLF, LYF), Thomas Jefferson University, Philadelphia, PA; Center for Genome Research (CT, GMT), Department of Life Sciences (TS), University of Modena and Reggio Emilia, Modena, Italy (CT, GMT); Transcriptional Networks in Lung Cancer Group, Manchester Institute, University of Manchester, UK (MG, SN).

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http://jnci.oxfordjournals.org/content/107/11/djv220.full.pd
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http://jnci.oxfordjournals.org/lookup/doi/10.1093/jnci/djv22
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http://dx.doi.org/10.1093/jnci/djv220DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4675101PMC
November 2015

MicroRNA profiles discriminate among colon cancer metastasis.

Authors:
Alessandra Drusco Gerard J Nuovo Nicola Zanesi Gianpiero Di Leva Flavia Pichiorri Stefano Volinia Cecilia Fernandez Anna Antenucci Stefan Costinean Arianna Bottoni Immacolata A Rosito Chang-Gong Liu Aaron Burch Mario Acunzo Yuri Pekarsky Hansjuerg Alder Antonio Ciardi Carlo M Croce

PLoS One 2014 12;9(6):e96670. Epub 2014 Jun 12.

MVIMG, Ohio State University, Columbus, Ohio, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0096670PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4055753PMC
October 2015

MYC-repressed long noncoding RNAs antagonize MYC-induced cell proliferation and cell cycle progression.

Authors:
Taewan Kim Ri Cui Young-Jun Jeon Paolo Fadda Hansjuerg Alder Carlo M Croce

Oncotarget 2015 Aug;6(22):18780-9

Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4662455PMC
http://dx.doi.org/10.18632/oncotarget.3909DOI Listing
August 2015

A differentially expressed set of microRNAs in cerebro-spinal fluid (CSF) can diagnose CNS malignancies.

Authors:
Alessandra Drusco Arianna Bottoni Alessandro Laganà Mario Acunzo Matteo Fassan Luciano Cascione Anna Antenucci Prasanthi Kumchala Caterina Vicentini Marina P Gardiman Hansjuerg Alder Mariantonia A Carosi Mario Ammirati Stefano Gherardi Marilena Luscrì Carmine Carapella Nicola Zanesi Carlo M Croce

Oncotarget 2015 Aug;6(25):20829-39

MVIMG, The Ohio State University, Columbus, OH, USA.

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http://dx.doi.org/10.18632/oncotarget.4096DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4673232PMC
August 2015

A set of NF-κB-regulated microRNAs induces acquired TRAIL resistance in lung cancer.

Authors:
Young-Jun Jeon Justin Middleton Taewan Kim Alessandro Laganà Claudia Piovan Paola Secchiero Gerard J Nuovo Ri Cui Pooja Joshi Giulia Romano Gianpiero Di Leva Bum-Kyu Lee Hui-Lung Sun Yonghwan Kim Paolo Fadda Hansjuerg Alder Michela Garofalo Carlo M Croce

Proc Natl Acad Sci U S A 2015 Jun 15;112(26):E3355-64. Epub 2015 Jun 15.

Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University, Columbus, OH 43210;

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http://dx.doi.org/10.1073/pnas.1504630112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4491797PMC
June 2015

Role of MYC-regulated long noncoding RNAs in cell cycle regulation and tumorigenesis.

Authors:
Taewan Kim Young-Jun Jeon Ri Cui Ji-Hoon Lee Yong Peng Sung-Hak Kim Esmerina Tili Hansjuerg Alder Carlo M Croce

J Natl Cancer Inst 2015 Apr 6;107(4). Epub 2015 Feb 6.

Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX (TK); Department of Molecular Virology, Immunology and Medical Genetics (TK, YJJ, RC, ET, HA, CMC), Department of Neurological Surgery (SHK), and Department of Anesthesiology (ET), Wexner Medical Center, The Ohio State University, OH; School of Biological Sciences, Seoul National University and National Creative Research Initiative Center for Symbiosystem, Seoul, Republic of Korea (JHL); State Key Laboratory of Biotherapy/Collaborative Innovation Center of Biotherapy, West China Hospital, Sichuan University, Chengdu, China (YP); School of Life Sciences and Biotechnology, Korea University, Republic of Korea (SHK).

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http://dx.doi.org/10.1093/jnci/dju505DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4402359PMC
April 2015

Egg yolks inhibit activation of NF-κB and expression of its target genes in adipocytes after partial delipidation.

Authors:
Qiwen Shen Ken M Riedl Rachel M Cole Christopher Lehman Lu Xu Hansjuerg Alder Martha A Belury Steven J Schwartz Ouliana Ziouzenkova

J Agric Food Chem 2015 Feb 12;63(7):2013-25. Epub 2015 Feb 12.

Department of Human Sciences, The Ohio State University , 1787 Neil Avenue, 331A Campbell Hall, Columbus, Ohio 43210, United States.

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http://dx.doi.org/10.1021/jf5056584DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4362627PMC
February 2015

Pluripotent stem cell miRNAs and metastasis in invasive breast cancer.

Authors:
Stefano Volinia Gerard Nuovo Alessandra Drusco Stefan Costinean Ramzey Abujarour Caroline Desponts Michela Garofalo Raffaele Baffa Rami Aeqilan Kati Maharry Maria Elena Sana Maria Elena Sana Ramiro Garzon Gianpiero Di Leva Pierluigi Gasparini Paola Dama Jlenia Marchesini Marco Galasso Marco Manfrini Carlotta Zerbinati Fabio Corrà Timothy Wise Sylwia E Wojcik Maurizio Previati Flavia Pichiorri Nicola Zanesi Hansjuerg Alder Jeff Palatini Kay F Huebner Charles L Shapiro Massimo Negrini Andrea Vecchione Anne L Rosenberg Carlo M Croce Ramiro Garzon

J Natl Cancer Inst 2014 Dec 11;106(12). Epub 2014 Oct 11.

Department of Molecular Virology, Immunology and Molecular Genetics, Comprehensive Cancer Center, The Ohio State University, Columbus, OH (SV, GN, AD, SC, MiG, RAe, RG, GDL, PG, PD, TW, SEW, FP, NZ, HA, KFH, CMC); Biosystems Analysis, LTTA, Deptartment of Morphology, Surgery and Experimental Medicine, University of Ferrara, Ferrara, Italy, (SV, MES, JM, MaG, MM, CZ, FC, MP, JP, MN); Fate Therapeutics, San Diego, CA (RAb); Department of Chemistry, The Scripps Research Institute, La Jolla, CA (CD); Department of Urology, Thomas Jefferson University, Kimmel Cancer Center, Philadelphia, PA (RB); Comprehensive Cancer Center, The Ohio State University, Columbus, OH (KM); Deptartment of Internal Medicine, James Cancer Hospital and Ohio State University Comprehensive Cancer Center, The Ohio State University (CLS); Division of Pathology, II University of Rome "La Sapienza," Ospedale Santo Andrea, Rome, Italy (AV); Department of Surgery, Thomas Jefferson University Medical College, Philadelphia, PA (ALR).

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http://dx.doi.org/10.1093/jnci/dju324DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4334797PMC
December 2014

MicroRNA-135b promotes cancer progression by acting as a downstream effector of oncogenic pathways in colon cancer.

Authors:
Nicola Valeri Chiara Braconi Pierluigi Gasparini Claudio Murgia Andrea Lampis Viola Paulus-Hock Jonathan R Hart Lynn Ueno Sergei I Grivennikov Francesca Lovat Alessio Paone Luciano Cascione Khlea M Sumani Angelo Veronese Muller Fabbri Stefania Carasi Hansjuerg Alder Giovanni Lanza Roberta Gafa' Mary P Moyer Rachel A Ridgway Julia Cordero Gerard J Nuovo Wendy L Frankel Massimo Rugge Matteo Fassan Joanna Groden Peter K Vogt Michael Karin Owen J Sansom Carlo M Croce

Cancer Cell 2014 Apr;25(4):469-83

Human Cancer Genetics Program, Ohio State University Comprehensive Cancer Center, Columbus, OH 43212, USA. Electronic address:

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http://www.cell.com/cancer-cell/pdf/S1535-6108(14)00115-9.pd
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http://linkinghub.elsevier.com/retrieve/pii/S153561081400115
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http://dx.doi.org/10.1016/j.ccr.2014.03.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3995091PMC
April 2014

Long-range interaction and correlation between MYC enhancer and oncogenic long noncoding RNA CARLo-5.

Authors:
Taewan Kim Ri Cui Young-Jun Jeon Ji-Hoon Lee Ju Hee Lee Hosung Sim Jong Kook Park Paolo Fadda Esmerina Tili Hiroshi Nakanishi Man-Il Huh Sung-Hak Kim Ju Hwan Cho Bong Hwan Sung Yong Peng Tae Jin Lee Zhenghua Luo Hui-Lung Sun Huijun Wei Hansjuerg Alder Jeong Su Oh Kang Sup Shim Sang-Bong Ko Carlo M Croce

Proc Natl Acad Sci U S A 2014 Mar 4;111(11):4173-8. Epub 2014 Mar 4.

Department of Molecular Virology, Immunology and Medical Genetics and Department of Anesthesiology, Wexner Medical Center, and Department of Neurological Surgery, The Ohio State University, Columbus, OH 43210.

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http://www.pnas.org/cgi/doi/10.1073/pnas.1400350111
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http://dx.doi.org/10.1073/pnas.1400350111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3964128PMC
March 2014

Identification of sensitive serum microRNA biomarkers for radiation biodosimetry.

Authors:
Naduparambil Korah Jacob James V Cooley Tamara N Yee Jidhin Jacob Hansjuerg Alder Priyankara Wickramasinghe Kirsteen H Maclean Arnab Chakravarti

PLoS One 2013 25;8(2):e57603. Epub 2013 Feb 25.

Department of Radiation Oncology, Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0057603PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3581493PMC
January 2014

A differential microRNA profile distinguishes cholangiocarcinoma from pancreatic adenocarcinoma.

Authors:
Amy L Collins Sylwia Wojcik James Liu Wendy L Frankel Hansjuerg Alder Lianbo Yu Thomas D Schmittgen Carlo M Croce Mark Bloomston

Ann Surg Oncol 2014 Jan 18;21(1):133-8. Epub 2013 Sep 18.

Department of Surgery, The Ohio State University, Columbus, OH, USA.

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http://link.springer.com/10.1245/s10434-013-3240-y
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http://dx.doi.org/10.1245/s10434-013-3240-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4174364PMC
January 2014

Integrated microRNA and mRNA signatures associated with survival in triple negative breast cancer.

Authors:
Luciano Cascione Pierluigi Gasparini Francesca Lovat Stefania Carasi Alfredo Pulvirenti Alfredo Ferro Hansjuerg Alder Gang He Andrea Vecchione Carlo M Croce Charles L Shapiro Kay Huebner

PLoS One 2013 6;8(2):e55910. Epub 2013 Feb 6.

Department of Molecular Virology, Immunology and Medical Genetics, Ohio State University Wexner Medical Center, Columbus, Ohio, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0055910PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3566108PMC
August 2013

Estrogen mediated-activation of miR-191/425 cluster modulates tumorigenicity of breast cancer cells depending on estrogen receptor status.

Authors:
Gianpiero Di Leva Claudia Piovan Pierluigi Gasparini Apollinaire Ngankeu Cristian Taccioli Daniel Briskin Douglas G Cheung Brad Bolon Laura Anderlucci Hansjuerg Alder Gerard Nuovo Meng Li Marilena V Iorio Marco Galasso Ramasamy Santhanam Santhanam Ramasamy Guido Marcucci Danilo Perrotti Kimerly A Powell Anna Bratasz Michela Garofalo Kenneth P Nephew Carlo M Croce

PLoS Genet 2013 7;9(3):e1003311. Epub 2013 Mar 7.

Department of Molecular Virology, Immunology, and Medical Genetics, School of Medicine, The Ohio State University, Columbus, Ohio, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1003311DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3591271PMC
June 2013

A microRNA signature defines chemoresistance in ovarian cancer through modulation of angiogenesis.

Authors:
Andrea Vecchione Barbara Belletti Francesca Lovat Stefano Volinia Gennaro Chiappetta Simona Giglio Maura Sonego Roberto Cirombella Elisa Concetta Onesti Patrizia Pellegrini Daniela Califano Sandro Pignata Simona Losito Vincenzo Canzonieri Roberto Sorio Hansjuerg Alder Dorothee Wernicke Antonella Stoppacciaro Gustavo Baldassarre Carlo M Croce

Proc Natl Acad Sci U S A 2013 Jun 22;110(24):9845-50. Epub 2013 May 22.

Division of Pathology and Medical Oncology, Department of Clinical and Molecular Medicine, Faculty of Medicine and Psychology, University Sapienza, Santo Andrea Hospital, 00100 Rome, Italy.

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http://dx.doi.org/10.1073/pnas.1305472110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3683704PMC
June 2013

Toll-like receptor 3 (TLR3) activation induces microRNA-dependent reexpression of functional RARβ and tumor regression.

Authors:
Roberta Galli Alessio Paone Muller Fabbri Nicola Zanesi Federica Calore Luciano Cascione Mario Acunzo Antonella Stoppacciaro Andrea Tubaro Francesca Lovat Pierluigi Gasparini Paolo Fadda Hansjuerg Alder Stefano Volinia Antonio Filippini Elio Ziparo Anna Riccioli Carlo M Croce

Proc Natl Acad Sci U S A 2013 Jun 28;110(24):9812-7. Epub 2013 May 28.

Department of Anatomical, Histological, Forensic & Orthopaedic Sciences, DAHFMO, Unit of Histology and Medical Embryology, Istituto Pasteur-Fondazione Cenci Bolognetti, La Sapienza University of Rome, 00161 Rome, Italy.

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http://dx.doi.org/10.1073/pnas.1304610110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3683754PMC
June 2013

Autocrine function of aldehyde dehydrogenase 1 as a determinant of diet- and sex-specific differences in visceral adiposity.

Authors:
Rumana Yasmeen Barbara Reichert Jeffrey Deiuliis Fangping Yang Alisha Lynch Joseph Meyers Molly Sharlach Sangsu Shin Katharina S Volz Kari B Green Kichoon Lee Hansjuerg Alder Gregg Duester Rudolf Zechner Sanjay Rajagopalan Ouliana Ziouzenkova

Diabetes 2013 Jan 28;62(1):124-36. Epub 2012 Aug 28.

Department of Human Nutrition, The Ohio State University, Columbus, Ohio, USA.

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http://dx.doi.org/10.2337/db11-1779DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3526050PMC
January 2013

Dysregulation of miR-31 and miR-21 induced by zinc deficiency promotes esophageal cancer.

Authors:
Hansjuerg Alder Cristian Taccioli Hongping Chen Yubao Jiang Karl J Smalley Paolo Fadda Hatice G Ozer Kay Huebner John L Farber Carlo M Croce Louise Y Y Fong

Carcinogenesis 2012 Sep 10;33(9):1736-44. Epub 2012 Jun 10.

Department of Molecular Virology, Immunology, and Medical Genetics, Comprehensive Cancer Center, The Ohio State University Columbus, OH 43210, USA.

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http://dx.doi.org/10.1093/carcin/bgs204DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3514898PMC
September 2012

miRNA profiling for biomarker discovery in multiple sclerosis: from microarray to deep sequencing.

Authors:
Mireia Guerau-de-Arellano Hansjuerg Alder Hatice Gulcin Ozer Amy Lovett-Racke Michael K Racke

J Neuroimmunol 2012 Jul 9;248(1-2):32-9. Epub 2011 Nov 9.

Neurology Department, The Ohio State University Medical Center, 460 W 12th Ave Room 0705, Columbus, OH 43210, USA.

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http://dx.doi.org/10.1016/j.jneuroim.2011.10.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3288464PMC
July 2012

MicroRNAs bind to Toll-like receptors to induce prometastatic inflammatory response.

Authors:
Muller Fabbri Alessio Paone Federica Calore Roberta Galli Eugenio Gaudio Ramasamy Santhanam Francesca Lovat Paolo Fadda Charlene Mao Gerard J Nuovo Nicola Zanesi Melissa Crawford Gulcin H Ozer Dorothee Wernicke Hansjuerg Alder Michael A Caligiuri Patrick Nana-Sinkam Danilo Perrotti Carlo M Croce

Proc Natl Acad Sci U S A 2012 Jul 2;109(31):E2110-6. Epub 2012 Jul 2.

Department of Molecular Virology, The Ohio State University Comprehensive Cancer Center, Columbus, OH 43210, USA.

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http://dx.doi.org/10.1073/pnas.1209414109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3412003PMC
July 2012

MicroRNAs/TP53 feedback circuitry in glioblastoma multiforme.

Authors:
Sung-Suk Suh Ji Young Yoo Gerard J Nuovo Young-Jun Jeon Seokho Kim Tae Jin Lee Taewan Kim Arianna Bakàcs Hansjuerg Alder Balveen Kaur Rami I Aqeilan Flavia Pichiorri Carlo M Croce

Proc Natl Acad Sci U S A 2012 Apr 19;109(14):5316-21. Epub 2012 Mar 19.

Department of Molecular Virology, Immunology, and Medical Genetics, Comprehensive Cancer Center, Ohio State University, Columbus, OH 43210, USA.

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http://dx.doi.org/10.1073/pnas.1202465109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3325690PMC
April 2012

Tcl1 protein functions as an inhibitor of de novo DNA methylation in B-cell chronic lymphocytic leukemia (CLL).

Authors:
Alexey Palamarchuk Pearlly S Yan Nicola Zanesi Linan Wang Benjamin Rodrigues Mark Murphy Veronica Balatti Arianna Bottoni Natalya Nazaryan Hansjuerg Alder Laura Rassenti Thomas J Kipps Michael Freitas Carlo M Croce Yuri Pekarsky

Proc Natl Acad Sci U S A 2012 Feb 30;109(7):2555-60. Epub 2012 Jan 30.

Human Cancer Genetics Program and Department of Molecular Virology, Immunology and Medical Genetics, Ohio State University School of Medicine, Columbus, OH 43210, USA.

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http://dx.doi.org/10.1073/pnas.1200003109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3289317PMC
February 2012

NOTCH1 mutations in CLL associated with trisomy 12.

Authors:
Veronica Balatti Arianna Bottoni Alexey Palamarchuk Hansjuerg Alder Laura Z Rassenti Thomas J Kipps Yuri Pekarsky Carlo M Croce

Blood 2012 Jan 15;119(2):329-31. Epub 2011 Nov 15.

Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, The Ohio State University, Columbus, USA.

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http://dx.doi.org/10.1182/blood-2011-10-386144DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3257004PMC
January 2012

EGFR and MET receptor tyrosine kinase-altered microRNA expression induces tumorigenesis and gefitinib resistance in lung cancers.

Authors:
Michela Garofalo Giulia Romano Gianpiero Di Leva Gerard Nuovo Young-Jun Jeon Apollinaire Ngankeu Jin Sun Francesca Lovat Hansjuerg Alder Gerolama Condorelli Jeffrey A Engelman Mayumi Ono Jin Kyung Rho Luciano Cascione Stefano Volinia Kenneth P Nephew Carlo M Croce

Nat Med 2011 Dec 11;18(1):74-82. Epub 2011 Dec 11.

Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, Ohio State University, Columbus, Ohio, USA.

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http://dx.doi.org/10.1038/nm.2577DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3467100PMC
December 2011

IRF4 mutations in chronic lymphocytic leukemia.

Authors:
Violaine Havelange Yuri Pekarsky Tatsuya Nakamura Alexey Palamarchuk Hansjuerg Alder Laura Rassenti Thomas Kipps Carlo M Croce

Blood 2011 Sep 25;118(10):2827-9. Epub 2011 Jul 25.

Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA.

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http://dx.doi.org/10.1182/blood-2011-04-350579DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3172799PMC
September 2011

Concerted action of aldehyde dehydrogenases influences depot-specific fat formation.

Authors:
Barbara Reichert Rumana Yasmeen Shanmugam M Jeyakumar Fangping Yang Thomas Thomou Hansjuerg Alder Gregg Duester Andrei Maiseyeu Georgeta Mihai Earl H Harrison Sanjay Rajagopalan James L Kirkland Ouliana Ziouzenkova

Mol Endocrinol 2011 May 24;25(5):799-809. Epub 2011 Mar 24.

Department of Human Nutrition, Ohio State University, Columbus, Ohio, 43210, USA.

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http://dx.doi.org/10.1210/me.2010-0465DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3082326PMC
May 2011

p53 regulates epithelial-mesenchymal transition through microRNAs targeting ZEB1 and ZEB2.

Authors:
Taewan Kim Angelo Veronese Flavia Pichiorri Tae Jin Lee Young-Jun Jeon Stefano Volinia Pascal Pineau Agnès Marchio Jeff Palatini Sung-Suk Suh Hansjuerg Alder Chang-Gong Liu Anne Dejean Carlo M Croce

J Exp Med 2011 May 25;208(5):875-83. Epub 2011 Apr 25.

Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, 2 Molecular, Cellular, and Developmental Biology Program, The Ohio State University, Columbus, OH 43210, USA.

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May 2011

Down-regulation of homeobox genes MEIS1 and HOXA in MLL-rearranged acute leukemia impairs engraftment and reduces proliferation.

Authors:
Kira Orlovsky Alexander Kalinkovich Tanya Rozovskaia Elias Shezen Tomer Itkin Hansjuerg Alder Hatice Gulcin Ozer Letizia Carramusa Abraham Avigdor Stefano Volinia Arthur Buchberg Alex Mazo Orit Kollet Corey Largman Carlo M Croce Tatsuya Nakamura Tsvee Lapidot Eli Canaani

Proc Natl Acad Sci U S A 2011 May 25;108(19):7956-61. Epub 2011 Apr 25.

Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel.

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May 2011

Mutations in U4atac snRNA, a component of the minor spliceosome, in the developmental disorder MOPD I.

Authors:
Huiling He Sandya Liyanarachchi Keiko Akagi Rebecca Nagy Jingfeng Li Rosemary C Dietrich Wei Li Nikhil Sebastian Bernard Wen Baozhong Xin Jarnail Singh Pearlly Yan Hansjuerg Alder Eric Haan Dagmar Wieczorek Beate Albrecht Erik Puffenberger Heng Wang Judith A Westman Richard A Padgett David E Symer Albert de la Chapelle

Science 2011 Apr;332(6026):238-40

Human Cancer Genetics Program, Ohio State University, Columbus, OH 43210, USA.

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http://dx.doi.org/10.1126/science.1200587DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3380448PMC
April 2011

Mutator activity induced by microRNA-155 (miR-155) links inflammation and cancer.

Authors:
Esmerina Tili Jean-Jacques Michaille Dorothee Wernicke Hansjuerg Alder Stefan Costinean Stefano Volinia Carlo M Croce

Proc Natl Acad Sci U S A 2011 Mar 7;108(12):4908-13. Epub 2011 Mar 7.

Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University Medical Center, Columbus, OH 43210, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3064319PMC
March 2011

MicroRNA-375 and MicroRNA-221: Potential Noncoding RNAs Associated with Antiproliferative Activity of Benzyl Isothiocyanate in Pancreatic Cancer.

Authors:
Aruna Basu Hansjuerg Alder Amer Khiyami Patrick Leahy Carlo M Croce Subrata Haldar

Genes Cancer 2011 Feb;2(2):108-19

Center for Biomedical Sciences, MetroHealth Campus, Case Western Reserve University, Cleveland, OH, USA.

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http://dx.doi.org/10.1177/1947601911409212DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3111247PMC
February 2011

Association of a microRNA/TP53 feedback circuitry with pathogenesis and outcome of B-cell chronic lymphocytic leukemia.

Authors:
Muller Fabbri Arianna Bottoni Masayoshi Shimizu Riccardo Spizzo Milena S Nicoloso Simona Rossi Elisa Barbarotto Amelia Cimmino Brett Adair Sylwia E Wojcik Nicola Valeri Federica Calore Deepa Sampath Francesca Fanini Ivan Vannini Gerardo Musuraca Marie Dell'Aquila Hansjuerg Alder Ramana V Davuluri Laura Z Rassenti Massimo Negrini Tatsuya Nakamura Dino Amadori Neil E Kay Kanti R Rai Michael J Keating Thomas J Kipps George A Calin Carlo M Croce

JAMA 2011 Jan;305(1):59-67

Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, Ohio State University, Columbus, OH 43210, USA.

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http://dx.doi.org/10.1001/jama.2010.1919DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3690301PMC
January 2011

Resveratrol modulates the levels of microRNAs targeting genes encoding tumor-suppressors and effectors of TGFβ signaling pathway in SW480 cells.

Authors:
Esmerina Tili Jean-Jacques Michaille Hansjuerg Alder Stefano Volinia Dominique Delmas Norbert Latruffe Carlo M Croce

Biochem Pharmacol 2010 Dec 15;80(12):2057-65. Epub 2010 Jul 15.

Ohio State University, Department of Molecular Virology, Immunology and Medical Genetics, Columbus, OH 43210, USA.

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http://dx.doi.org/10.1016/j.bcp.2010.07.003DOI Listing
December 2010

Role of PTPRJ genotype in papillary thyroid carcinoma risk.

Authors:
Rodolfo Iuliano Dario Palmieri Huiling He Angela Iervolino Eleonora Borbone Pierlorenzo Pallante Alessandra Cianflone Rebecca Nagy Hansjuerg Alder George A Calin Francesco Trapasso Carla Giordano Carlo M Croce Albert de la Chapelle Alfredo Fusco

Endocr Relat Cancer 2010 Dec 29;17(4):1001-6. Epub 2010 Oct 29.

Dipartimento di Medicina Sperimentale e Clinica, Facoltà di Medicina e Chirurgia, Università degli Studi Magna Græcia di Catanzaro, Campus Salvatore Venuta, Viale Europa, località Germaneto, Catanzaro, Italy.

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http://dx.doi.org/10.1677/ERC-10-0143DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3915780PMC
December 2010

MicroRNA-21 induces resistance to 5-fluorouracil by down-regulating human DNA MutS homolog 2 (hMSH2).

Authors:
Nicola Valeri Pierluigi Gasparini Chiara Braconi Alessio Paone Francesca Lovat Muller Fabbri Khlea M Sumani Hansjuerg Alder Dino Amadori Tushar Patel Gerard J Nuovo Richard Fishel Carlo M Croce

Proc Natl Acad Sci U S A 2010 Dec 15;107(49):21098-103. Epub 2010 Nov 15.

Departments of Molecular Virology, Ohio State University Comprehensive Cancer Center, Ohio State University, Columbus, OH 43210, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3000294PMC
December 2010

GAM/ZFp/ZNF512B is central to a gene sensor circuitry involving cell-cycle regulators, TGF{beta} effectors, Drosha and microRNAs with opposite oncogenic potentials.

Authors:
Esmerina Tili Jean-Jacques Michaille Chang-Gong Liu Hansjuerg Alder Cristian Taccioli Stefano Volinia George A Calin Carlo M Croce

Nucleic Acids Res 2010 Nov 17;38(21):7673-88. Epub 2010 Jul 17.

Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, Ohio State University, Biological Research Tower, Columbus, OH 43210, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2995059PMC
November 2010

Downregulation of p53-inducible microRNAs 192, 194, and 215 impairs the p53/MDM2 autoregulatory loop in multiple myeloma development.

Authors:
Flavia Pichiorri Sung-Suk Suh Alberto Rocci Luciana De Luca Cristian Taccioli Ramasamy Santhanam Wenchao Zhou Don M Benson Craig Hofmainster Hansjuerg Alder Michela Garofalo Gianpiero Di Leva Stefano Volinia Huey-Jen Lin Danilo Perrotti Michael Kuehl Rami I Aqeilan Antonio Palumbo Carlo M Croce

Cancer Cell 2010 Oct;18(4):367-81

Department of Molecular Virology, Comprehensive Cancer Center, Ohio State University, Columbus, 43210, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3561766PMC
October 2010

Resveratrol decreases the levels of miR-155 by upregulating miR-663, a microRNA targeting JunB and JunD.

Authors:
Esmerina Tili Jean-Jacques Michaille Brett Adair Hansjuerg Alder Emeric Limagne Cristian Taccioli Manuela Ferracin Dominique Delmas Norbert Latruffe Carlo M Croce

Carcinogenesis 2010 Sep 9;31(9):1561-6. Epub 2010 Jul 9.

Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University, Biomedical Tower, 460 West 12th Avenue, Columbus, OH 43210, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4647642PMC
September 2010

Chronic lymphocytic leukemia modeled in mouse by targeted miR-29 expression.

Authors:
Urmila Santanam Nicola Zanesi Alexey Efanov Stefan Costinean Alexey Palamarchuk John P Hagan Stefano Volinia Hansjuerg Alder Laura Rassenti Thomas Kipps Carlo M Croce Yuri Pekarsky

Proc Natl Acad Sci U S A 2010 Jul 21;107(27):12210-5. Epub 2010 Jun 21.

Department of Molecular Virology, Ohio State University School of Medicine, Ohio State University, Columbus, OH 43210, USA.

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July 2010

MicroRNA profiles of drug-resistant myeloma cell lines.

Authors:
Reinhold Munker Chang-Gong Liu Cristian Taccioli Hansjuerg Alder Nyla Heerema

Acta Haematol 2010 31;123(4):201-4. Epub 2010 Mar 31.

Louisiana State University, Shreveport, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2881892PMC
June 2010

Comprehensive miRNA profiling of surgically staged endometrial cancer.

Authors:
David E Cohn Muller Fabbri Nicola Valeri Hansjuerg Alder Iouri Ivanov Chang-Gong Liu Carlo M Croce Kimberly E Resnick

Am J Obstet Gynecol 2010 Jun 18;202(6):656.e1-8. Epub 2010 Apr 18.

Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, The Ohio State University College of Medicine, Columbus, OH, USA.

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http://dx.doi.org/10.1016/j.ajog.2010.02.051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4278076PMC
June 2010

13q14 deletions in CLL involve cooperating tumor suppressors.

Authors:
Alexey Palamarchuk Alexey Efanov Natalya Nazaryan Urmila Santanam Hansjuerg Alder Laura Rassenti Thomas Kipps Carlo M Croce Yuri Pekarsky

Blood 2010 May 13;115(19):3916-22. Epub 2010 Jan 13.

Human Cancer Genetics Program and Comprehensive Cancer Center, Department of Molecular Virology, Immunology and Medical Genetics, School of Medicine, Ohio State University, Columbus, OH, USA

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http://dx.doi.org/10.1182/blood-2009-10-249367DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2869560PMC
May 2010

MicroRNA cluster 221-222 and estrogen receptor alpha interactions in breast cancer.

Authors:
Gianpiero Di Leva Pierluigi Gasparini Claudia Piovan Apollinaire Ngankeu Michela Garofalo Cristian Taccioli Marilena V Iorio Meng Li Stefano Volinia Hansjuerg Alder Tatsuya Nakamura Gerard Nuovo Yunlong Liu Kenneth P Nephew Carlo M Croce

J Natl Cancer Inst 2010 May 13;102(10):706-21. Epub 2010 Apr 13.

Department of Molecular Virology, Immunology and Medical Genetics and Comprehensive Cancer Center, Ohio State University, 460 West, 12th Ave, Columbus, OH 43210, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2873185PMC
May 2010

Modulation of mismatch repair and genomic stability by miR-155.

Authors:
Nicola Valeri Pierluigi Gasparini Muller Fabbri Chiara Braconi Angelo Veronese Francesca Lovat Brett Adair Ivan Vannini Francesca Fanini Arianna Bottoni Stefan Costinean Sukhinder K Sandhu Gerard J Nuovo Hansjuerg Alder Roberta Gafa Federica Calore Manuela Ferracin Giovanni Lanza Stefano Volinia Massimo Negrini Michael A McIlhatton Dino Amadori Richard Fishel Carlo M Croce

Proc Natl Acad Sci U S A 2010 Apr 29;107(15):6982-7. Epub 2010 Mar 29.

Department of Molecular Virology, Immunology and Medical Genetics, Ohio State University Medical Center, Columbus, OH 43210, USA.

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http://dx.doi.org/10.1073/pnas.1002472107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2872463PMC
April 2010

Oncogenic role of miR-483-3p at the IGF2/483 locus.

Authors:
Angelo Veronese Laura Lupini Jessica Consiglio Rosa Visone Manuela Ferracin Francesca Fornari Nicola Zanesi Hansjuerg Alder Gemma D'Elia Laura Gramantieri Luigi Bolondi Giovanni Lanza Patrizia Querzoli Adriano Angioni Carlo M Croce Massimo Negrini

Cancer Res 2010 Apr 13;70(8):3140-9. Epub 2010 Apr 13.

Dipartimento di Medicina Sperimentale e Diagnostica, Università di Ferrara, Ferrara, Italy.

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http://dx.doi.org/10.1158/0008-5472.CAN-09-4456DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4303586PMC
April 2010

Non-codingRNA sequence variations in human chronic lymphocytic leukemia and colorectal cancer.

Authors:
Sylwia E Wojcik Simona Rossi Masayoshi Shimizu Milena S Nicoloso Amelia Cimmino Hansjuerg Alder Vlad Herlea Laura Z Rassenti Kanti R Rai Thomas J Kipps Michael J Keating Carlo M Croce George A Calin

Carcinogenesis 2010 Feb 19;31(2):208-15. Epub 2009 Nov 19.

Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University, Columbus, OH 43210, USA.

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https://academic.oup.com/carcin/article-lookup/doi/10.1093/c
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http://dx.doi.org/10.1093/carcin/bgp209DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2812567PMC
February 2010

Relation between microRNA expression and progression and prognosis of gastric cancer: a microRNA expression analysis.

Authors:
Tetsuya Ueda Stefano Volinia Hiroshi Okumura Masayoshi Shimizu Cristian Taccioli Simona Rossi Hansjuerg Alder Chang-gong Liu Naohide Oue Wataru Yasui Kazuhiro Yoshida Hiroki Sasaki Sachiyo Nomura Yasuyuki Seto Michio Kaminishi George A Calin Carlo M Croce

Lancet Oncol 2010 Feb 18;11(2):136-46. Epub 2009 Dec 18.

Department of Molecular Virology, Immunology, Ohio State University, Columbus, OH 43210, USA.

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http://dx.doi.org/10.1016/S1470-2045(09)70343-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4299826PMC
February 2010

miR-221&222 regulate TRAIL resistance and enhance tumorigenicity through PTEN and TIMP3 downregulation.

Authors:
Michela Garofalo Gianpiero Di Leva Giulia Romano Gerard Nuovo Sung-Suk Suh Apollinaire Ngankeu Cristian Taccioli Flavia Pichiorri Hansjuerg Alder Paola Secchiero Pierluigi Gasparini Arianna Gonelli Stefan Costinean Mario Acunzo Gerolama Condorelli Carlo Maria Croce

Cancer Cell 2009 Dec;16(6):498-509

Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, Ohio State University, Columbus, OH 43210, USA.

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http://dx.doi.org/10.1016/j.ccr.2009.10.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2796583PMC
December 2009

Karyotype-specific microRNA signature in chronic lymphocytic leukemia.

Authors:
Rosa Visone Laura Z Rassenti Angelo Veronese Cristian Taccioli Stefan Costinean Baltazar D Aguda Stefano Volinia Manuela Ferracin Jeff Palatini Veronica Balatti Hansjuerg Alder Massimo Negrini Thomas J Kipps Carlo M Croce

Blood 2009 Oct 28;114(18):3872-9. Epub 2009 Aug 28.

Department of Molecular Virology, Immunology, and Medical Genetics and Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA.

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http://dx.doi.org/10.1182/blood-2009-06-229211DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2773482PMC
October 2009

Targeted disruption of the murine homeodomain-interacting protein kinase-2 causes growth deficiency in vivo and cell cycle arrest in vitro.

Authors:
Francesco Trapasso Rami I Aqeilan Rodolfo Iuliano Rosa Visone Eugenio Gaudio Laura Ciuffini Hansjuerg Alder Francesco Paduano Giovanna Maria Pierantoni Silvia Soddu Carlo M Croce Alfredo Fusco

DNA Cell Biol 2009 Apr;28(4):161-7

Department of Molecular Virology, Immunology and Medical Genetics and Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, USA.

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http://dx.doi.org/10.1089/dna.2008.0778DOI Listing
April 2009

Targeted ablation of the WW domain-containing oxidoreductase tumor suppressor leads to impaired steroidogenesis.

Authors:
Rami I Aqeilan John P Hagan Alain de Bruin Maysoon Rawahneh Zaidoun Salah Eugenio Gaudio Hasan Siddiqui Stefano Volinia Hansjuerg Alder Jane B Lian Gary S Stein Carlo M Croce

Endocrinology 2009 Mar 30;150(3):1530-5. Epub 2008 Oct 30.

Department of Molecular Virology, Comprehensive Cancer Center, Ohio State University, Columbus, Ohio 43210, USA.

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http://dx.doi.org/10.1210/en.2008-1087DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2654736PMC
March 2009

Zinc replenishment reverses overexpression of the proinflammatory mediator S100A8 and esophageal preneoplasia in the rat.

Authors:
Cristian Taccioli Shao-Gui Wan Chang-Gong Liu Hansjuerg Alder Stefano Volinia John L Farber Carlo M Croce Louise Y Y Fong

Gastroenterology 2009 Mar 24;136(3):953-66. Epub 2008 Nov 24.

Department of Molecular Virology, Immunology, and Medical Genetics, Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, USA.

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http://dx.doi.org/10.1053/j.gastro.2008.11.039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2650087PMC
March 2009

The detection of differentially expressed microRNAs from the serum of ovarian cancer patients using a novel real-time PCR platform.

Authors:
Kimberly E Resnick Hansjuerg Alder John P Hagan Debra L Richardson Carlo M Croce David E Cohn

Gynecol Oncol 2009 Jan 26;112(1):55-9. Epub 2008 Oct 26.

Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, The Ohio State University College of Medicine, Columbus, Ohio 43210, USA.

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http://dx.doi.org/10.1016/j.ygyno.2008.08.036DOI Listing
January 2009

Genome wide identification of recessive cancer genes by combinatorial mutation analysis.

Authors:
Stefano Volinia Nicoletta Mascellani Jlenia Marchesini Angelo Veronese Elizabeth Ormondroyd Hansjuerg Alder Jeff Palatini Massimo Negrini Carlo M Croce

PLoS One 2008 10;3(10):e3380. Epub 2008 Oct 10.

Data Mining for Analysis of Microarrays, Università degli Studi, Ferrara, Italy.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2557123PMC
November 2008

MicroRNAs regulate critical genes associated with multiple myeloma pathogenesis.

Authors:
Flavia Pichiorri Sung-Suk Suh Marco Ladetto Michael Kuehl Tiziana Palumbo Daniela Drandi Cristian Taccioli Nicola Zanesi Hansjuerg Alder John P Hagan Reinhold Munker Stefano Volinia Mario Boccadoro Ramiro Garzon Antonio Palumbo Rami I Aqeilan Carlo M Croce

Proc Natl Acad Sci U S A 2008 Sep 26;105(35):12885-90. Epub 2008 Aug 26.

Department of Molecular Virology, Ohio State University, Columbus, OH 43210, USA.

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http://dx.doi.org/10.1073/pnas.0806202105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2529070PMC
September 2008

MiR-15a and miR-16-1 cluster functions in human leukemia.

Authors:
George A Calin Amelia Cimmino Muller Fabbri Manuela Ferracin Sylwia E Wojcik Masayoshi Shimizu Cristian Taccioli Nicola Zanesi Ramiro Garzon Rami I Aqeilan Hansjuerg Alder Stefano Volinia Laura Rassenti Xiuping Liu Chang-Gong Liu Thomas J Kipps Massimo Negrini Carlo M Croce

Proc Natl Acad Sci U S A 2008 Apr 24;105(13):5166-71. Epub 2008 Mar 24.

Human Cancer Genetics Program and Department of Molecular Virology, Immunology, and Medical Genetics, Ohio State University, Columbus, OH 43210, USA.

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http://dx.doi.org/10.1073/pnas.0800121105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2278188PMC
April 2008

MicroRNA signatures associated with cytogenetics and prognosis in acute myeloid leukemia.

Authors:
Ramiro Garzon Stefano Volinia Chang-Gong Liu Cecilia Fernandez-Cymering Tiziana Palumbo Flavia Pichiorri Muller Fabbri Kevin Coombes Hansjuerg Alder Tatsuya Nakamura Neal Flomenberg Guido Marcucci George A Calin Steven M Kornblau Hagop Kantarjian Clara D Bloomfield Michael Andreeff Carlo M Croce

Blood 2008 Mar 10;111(6):3183-9. Epub 2008 Jan 10.

Division of Hematology and Oncology, Department of Internal Medicine, Comprehensive Cancer Center, Ohio State University, Columbus, OH 43210, USA.

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http://dx.doi.org/10.1182/blood-2007-07-098749DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2265455PMC
March 2008

E2F1-regulated microRNAs impair TGFbeta-dependent cell-cycle arrest and apoptosis in gastric cancer.

Authors:
Fabio Petrocca Rosa Visone Mariadele Rapazzotti Onelli Manisha H Shah Milena S Nicoloso Ivana de Martino Dimitrios Iliopoulos Emanuela Pilozzi Chang-Gong Liu Massimo Negrini Luigi Cavazzini Stefano Volinia Hansjuerg Alder Luigi P Ruco Gustavo Baldassarre Carlo M Croce Andrea Vecchione

Cancer Cell 2008 Mar;13(3):272-86

Department of Molecular Virology, Immunology and Medical Genetics, Human Cancer Genetics Program, Ohio State University, 460 West 12th Avenue, Columbus, OH 43210, USA.

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March 2008

MicroRNA-29 family reverts aberrant methylation in lung cancer by targeting DNA methyltransferases 3A and 3B.

Authors:
Muller Fabbri Ramiro Garzon Amelia Cimmino Zhongfa Liu Nicola Zanesi Elisa Callegari Shujun Liu Hansjuerg Alder Stefan Costinean Cecilia Fernandez-Cymering Stefano Volinia Gulnur Guler Carl D Morrison Kenneth K Chan Guido Marcucci George A Calin Kay Huebner Carlo M Croce

Proc Natl Acad Sci U S A 2007 Oct 21;104(40):15805-10. Epub 2007 Sep 21.

Department of Molecular Virology, Immunology, and Medical Genetics, Comprehensive Cancer Center, and College of Pharmacy, Ohio State University, Columbus, OH 43210, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2000384PMC
October 2007

Ultraconserved regions encoding ncRNAs are altered in human leukemias and carcinomas.

Authors:
George A Calin Chang-gong Liu Manuela Ferracin Terry Hyslop Riccardo Spizzo Cinzia Sevignani Muller Fabbri Amelia Cimmino Eun Joo Lee Sylwia E Wojcik Masayoshi Shimizu Esmerina Tili Simona Rossi Cristian Taccioli Flavia Pichiorri Xiuping Liu Simona Zupo Vlad Herlea Laura Gramantieri Giovanni Lanza Hansjuerg Alder Laura Rassenti Stefano Volinia Thomas D Schmittgen Thomas J Kipps Massimo Negrini Carlo M Croce

Cancer Cell 2007 Sep;12(3):215-29

Comprehensive Cancer Center, Ohio State University, Columbus, OH 43210, USA.

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September 2007

MicroRNA signatures in human ovarian cancer.

Authors:
Marilena V Iorio Rosa Visone Gianpiero Di Leva Valentina Donati Fabio Petrocca Patrizia Casalini Cristian Taccioli Stefano Volinia Chang-Gong Liu Hansjuerg Alder George A Calin Sylvie Ménard Carlo M Croce

Cancer Res 2007 Sep;67(18):8699-707

Molecular Biology Unit, Department of Experimental Oncology, Fondazione Istituti di Ricovero e Cura a Carattere Scientifico, Istituto Nazionale Tumori, Milano, Italy.

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http://dx.doi.org/10.1158/0008-5472.CAN-07-1936DOI Listing
September 2007

MicroRNAs (miR)-221 and miR-222, both overexpressed in human thyroid papillary carcinomas, regulate p27Kip1 protein levels and cell cycle.

Authors:
Rosa Visone Lucia Russo Pierlorenzo Pallante Ivana De Martino Angelo Ferraro Vincenza Leone Eleonora Borbone Fabio Petrocca Hansjuerg Alder Carlo Maria Croce Alfredo Fusco

Endocr Relat Cancer 2007 Sep;14(3):791-8

Dipartimento di Biologia e Patologia Cellulare e Molecolare c/o Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, Facoltà di Medicina e Chirurgia, Università degli Studi di Napoli Federico II, via Pansini, 5, 80131 Naples, Italy.

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http://dx.doi.org/10.1677/ERC-07-0129DOI Listing
September 2007

MicroRNA expression patterns to differentiate pancreatic adenocarcinoma from normal pancreas and chronic pancreatitis.

Authors:
Mark Bloomston Wendy L Frankel Fabio Petrocca Stefano Volinia Hansjuerg Alder John P Hagan Chang-Gong Liu Darshna Bhatt Cristian Taccioli Carlo M Croce

JAMA 2007 May;297(17):1901-8

Division of Surgical Oncology, James Cancer Hospital and Solove Research Institute, Ohio State University, Columbus, USA.

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http://dx.doi.org/10.1001/jama.297.17.1901DOI Listing
May 2007

A microRNA signature of hypoxia.

Authors:
Ritu Kulshreshtha Manuela Ferracin Sylwia E Wojcik Ramiro Garzon Hansjuerg Alder Francisco J Agosto-Perez Ramana Davuluri Chang-Gong Liu Carlo M Croce Massimo Negrini George A Calin Mircea Ivan

Mol Cell Biol 2007 Mar 28;27(5):1859-67. Epub 2006 Dec 28.

Molecular Oncology Research Institute, Tufts-New England Medical Center, Boston, Massachusetts 02111, USA.

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http://dx.doi.org/10.1128/MCB.01395-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1820461PMC
March 2007

Fez1/Lzts1 absence impairs Cdk1/Cdc25C interaction during mitosis and predisposes mice to cancer development.

Authors:
Andrea Vecchione Gustavo Baldassarre Hideshi Ishii Milena S Nicoloso Barbara Belletti Fabio Petrocca Nicola Zanesi Louise Y Y Fong Sabrina Battista Daniela Guarnieri Raffaele Baffa Hansjuerg Alder John L Farber Peter J Donovan Carlo M Croce

Cancer Cell 2007 Mar;11(3):275-89

Department of Molecular Virology, Immunology, and Medical Genetics and Comprehensive Cancer Center, Ohio State University, Columbus, OH 43210, USA.

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http://dx.doi.org/10.1016/j.ccr.2007.01.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1987708PMC
March 2007

Tcl1 expression in chronic lymphocytic leukemia is regulated by miR-29 and miR-181.

Authors:
Yuri Pekarsky Urmila Santanam Amelia Cimmino Alexey Palamarchuk Alexey Efanov Vadim Maximov Stefano Volinia Hansjuerg Alder Chang-Gong Liu Laura Rassenti George A Calin John P Hagan Thomas Kipps Carlo M Croce

Cancer Res 2006 Dec;66(24):11590-3

Comprehensive Cancer Center, Human Cancer Genetics Program and Department of Molecular Virology, Immunology, and Medical Genetics, OSU School of Medicine, Ohio State University, Columbus, Ohio 43210, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-06-3613DOI Listing
December 2006

Genetic ablation of Ptprj, a mouse cancer susceptibility gene, results in normal growth and development and does not predispose to spontaneous tumorigenesis.

Authors:
Francesco Trapasso Alessandra Drusco Stefan Costinean Hansjuerg Alder Rami I Aqeilan Rodolfo Iuliano Eugenio Gaudio Cinzia Raso Nicola Zanesi Carlo M Croce Alfredo Fusco

DNA Cell Biol 2006 Jun;25(6):376-82

Dipartimento di Medicina Sperimentale e Clinica, Università Magna Graecia di Catanzaro, Campus Germaneto, Catanzaro, Italy.

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http://www.liebertpub.com/doi/10.1089/dna.2006.25.376
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http://dx.doi.org/10.1089/dna.2006.25.376DOI Listing
June 2006

MicroRNA fingerprints during human megakaryocytopoiesis.

Authors:
Ramiro Garzon Flavia Pichiorri Tiziana Palumbo Rodolfo Iuliano Amelia Cimmino Rami Aqeilan Stefano Volinia Darshna Bhatt Hansjuerg Alder Guido Marcucci George A Calin Chang-Gong Liu Clara D Bloomfield Michael Andreeff Carlo M Croce

Proc Natl Acad Sci U S A 2006 Mar 20;103(13):5078-83. Epub 2006 Mar 20.

Department of Molecular Virology, Comprehensive Cancer Center, Ohio State University, Columbus, OH 43210, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0600587103
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http://dx.doi.org/10.1073/pnas.0600587103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1458797PMC
March 2006

A MicroRNA signature associated with prognosis and progression in chronic lymphocytic leukemia.

Authors:
George Adrian Calin Manuela Ferracin Amelia Cimmino Gianpiero Di Leva Masayoshi Shimizu Sylwia E Wojcik Marilena V Iorio Rosa Visone Nurettin Ilfer Sever Muller Fabbri Rodolfo Iuliano Tiziana Palumbo Flavia Pichiorri Claudia Roldo Ramiro Garzon Cinzia Sevignani Laura Rassenti Hansjuerg Alder Stefano Volinia Chang-gong Liu Thomas J Kipps Massimo Negrini Carlo M Croce

N Engl J Med 2005 Oct;353(17):1793-801

Department of Molecular Virology, Immunology, and Medical Genetics and Comprehensive Cancer Center, Ohio State University, Columbus, OH 43210, USA.

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http://dx.doi.org/10.1056/NEJMoa050995DOI Listing
October 2005

miR-15 and miR-16 induce apoptosis by targeting BCL2.

Authors:
Amelia Cimmino George Adrian Calin Muller Fabbri Marilena V Iorio Manuela Ferracin Masayoshi Shimizu Sylwia E Wojcik Rami I Aqeilan Simona Zupo Mariella Dono Laura Rassenti Hansjuerg Alder Stefano Volinia Chang-Gong Liu Thomas J Kipps Massimo Negrini Carlo M Croce

Proc Natl Acad Sci U S A 2005 Sep 15;102(39):13944-9. Epub 2005 Sep 15.

Department of Molecular Virology, Immunology, and Medical Genetics and Comprehensive Cancer Center, Ohio State University, Columbus OH 43210, USA.

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http://dx.doi.org/10.1073/pnas.0506654102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1236577PMC
September 2005

Familial cancer associated with a polymorphism in ARLTS1.

Authors:
George Adrian Calin Francesco Trapasso Masayoshi Shimizu Calin Dan Dumitru Sai Yendamuri Andrew K Godwin Manuela Ferracin Guido Bernardi Devjani Chatterjee Gustavo Baldassarre Shashi Rattan Hansjuerg Alder Hideaki Mabuchi Takeshi Shiraishi Lise Lotte Hansen Jens Overgaard Vlad Herlea Francesca Romana Mauro Guillaume Dighiero Benjamin Movsas Laura Rassenti Thomas Kipps Raffaele Baffa Alfredo Fusco Masaki Mori Giandomenico Russo Chang-Gong Liu Donna Neuberg Florencia Bullrich Massimo Negrini Carlo M Croce

N Engl J Med 2005 Apr;352(16):1667-76

Thomas Jefferson University, Philadelphia, USA.

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http://dx.doi.org/10.1056/NEJMoa042280DOI Listing
April 2005

Therapy of human pancreatic carcinoma based on suppression of HMGA1 protein synthesis in preclinical models.

Authors:
Francesco Trapasso Manuela Sarti Rossano Cesari Sai Yendamuri Kristoffel R Dumon Rami I Aqeilan Francesca Pentimalli Luisa Infante Hansjuerg Alder Nobutsugu Abe Takashi Watanabe Giuseppe Viglietto Carlo M Croce Alfredo Fusco

Cancer Gene Ther 2004 Sep;11(9):633-41

Dipartimento di Biologia e Patologia Cellulare e Molecolare, c/o Centro di Endocrinologia ed Oncologia Sperimentale del CNR, Università di Napoli Federico II, Naples, Italy.

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http://dx.doi.org/10.1038/sj.cgt.7700745DOI Listing
September 2004

MicroRNA profiling reveals distinct signatures in B cell chronic lymphocytic leukemias.

Authors:
George Adrian Calin Chang-Gong Liu Cinzia Sevignani Manuela Ferracin Nadia Felli Calin Dan Dumitru Masayoshi Shimizu Amelia Cimmino Simona Zupo Mariella Dono Marie L Dell'Aquila Hansjuerg Alder Laura Rassenti Thomas J Kipps Florencia Bullrich Massimo Negrini Carlo M Croce

Proc Natl Acad Sci U S A 2004 Aug 29;101(32):11755-60. Epub 2004 Jul 29.

Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0404432101
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http://dx.doi.org/10.1073/pnas.0404432101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC511048PMC
August 2004

An oligonucleotide microchip for genome-wide microRNA profiling in human and mouse tissues.

Authors:
Chang-Gong Liu George Adrian Calin Brian Meloon Nir Gamliel Cinzia Sevignani Manuela Ferracin Calin Dan Dumitru Masayoshi Shimizu Simona Zupo Mariella Dono Hansjuerg Alder Florencia Bullrich Massimo Negrini Carlo M Croce

Proc Natl Acad Sci U S A 2004 Jun 21;101(26):9740-4. Epub 2004 Jun 21.

Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA.

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http://dx.doi.org/10.1073/pnas.0403293101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC470744PMC
June 2004

The tumor suppressor gene WWOX at FRA16D is involved in pancreatic carcinogenesis.

Authors:
Tamotsu Kuroki Sai Yendamuri Francesco Trapasso Ayumi Matsuyama Rami I Aqeilan Hansjuerg Alder Shashi Rattan Rossano Cesari Maria L Nolli Noel N Williams Masaki Mori Takashi Kanematsu Carlo M Croce

Clin Cancer Res 2004 Apr;10(7):2459-65

Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA.

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http://dx.doi.org/10.1158/1078-0432.ccr-03-0096DOI Listing
April 2004

Fragile site orthologs FHIT/FRA3B and Fhit/Fra14A2: evolutionarily conserved but highly recombinogenic.

Authors:
Ayumi Matsuyama Takeshi Shiraishi Francesco Trapasso Tamotsu Kuroki Hansjuerg Alder Masaki Mori Kay Huebner Carlo M Croce

Proc Natl Acad Sci U S A 2003 Dec 20;100(25):14988-93. Epub 2003 Nov 20.

Kimmel Cancer Center, Thomas Jefferson University, 233 South 10th Street, Philadelphia, PA 19107, USA.

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http://dx.doi.org/10.1073/pnas.2336256100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC299872PMC
December 2003

Allele loss and promoter hypermethylation of VHL, RAR-beta, RASSF1A, and FHIT tumor suppressor genes on chromosome 3p in esophageal squamous cell carcinoma.

Authors:
Tamotsu Kuroki Francesco Trapasso Sai Yendamuri Ayumi Matsuyama Hansjuerg Alder Masaki Mori Carlo M Croce

Cancer Res 2003 Jul;63(13):3724-8

Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA.

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July 2003

Regulation of BRCA1 transcription by specific single-stranded DNA binding factors.

Authors:
Sanjay Thakur Tatsuya Nakamura George Calin Andrea Russo Joseph F Tamburrino Masayoshi Shimizu Gustavo Baldassarre Sabrina Battista Alfredo Fusco Richard P Wassell Garret Dubois Hansjuerg Alder Carlo M Croce

Mol Cell Biol 2003 Jun;23(11):3774-87

Kimmel Cancer Center, Philadelphia, Pennsylvania 19107, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC155225PMC
http://dx.doi.org/10.1128/mcb.23.11.3774-3787.2003DOI Listing
June 2003

Allelic loss on chromosome 3p21.3 and promoter hypermethylation of semaphorin 3B in non-small cell lung cancer.

Authors:
Tamotsu Kuroki Francesco Trapasso Sai Yendamuri Ayumi Matsuyama Hansjuerg Alder Noel N Williams Larry R Kaiser Carlo M Croce

Cancer Res 2003 Jun;63(12):3352-5

Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA.

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June 2003

Parkin, a gene implicated in autosomal recessive juvenile parkinsonism, is a candidate tumor suppressor gene on chromosome 6q25-q27.

Authors:
Rossano Cesari Eric S Martin George A Calin Francesca Pentimalli Roberta Bichi Holly McAdams Francesco Trapasso Alessandra Drusco Masayoshi Shimizu Valeria Masciullo Giuseppina D'Andrilli Giovanni Scambia Maria Cristina Picchio Hansjuerg Alder Andrew K Godwin Carlo M Croce

Proc Natl Acad Sci U S A 2003 05 28;100(10):5956-61. Epub 2003 Apr 28.

Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0931262100
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http://dx.doi.org/10.1073/pnas.0931262100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC156308PMC
May 2003

Promoter hypermethylation of RASSF1A in esophageal squamous cell carcinoma.

Authors:
Tamotsu Kuroki Francesco Trapasso Sai Yendamuri Ayumi Matsuyama Hansjuerg Alder Masaki Mori Carlo M Croce

Clin Cancer Res 2003 Apr;9(4):1441-5

Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania, Pennsylvania 19107, USA.

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April 2003

FEZ1/LZTS1 is down-regulated in high-grade bladder cancer, and its restoration suppresses tumorigenicity in transitional cell carcinoma cells.

Authors:
Andrea Vecchione Hideshi Ishii Gustavo Baldassarre Pierfrancesco Bassi Francesco Trapasso Hansjuerg Alder Francesco Pagano Leonard G Gomella Carlo M Croce Raffaele Baffa

Am J Pathol 2002 Apr;160(4):1345-52

Department of Urology, Kimmel Cancer Center,Thomas Jefferson University, Philadelphia, Pennsylvania, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1867220PMC
http://dx.doi.org/10.1016/S0002-9440(10)62561-8DOI Listing
April 2002

Genetic alterations of the tumor suppressor gene WWOX in esophageal squamous cell carcinoma.

Authors:
Tamotsu Kuroki Francesco Trapasso Takeshi Shiraishi Hansjuerg Alder Koshi Mimori Masaki Mori Carlo M Croce

Cancer Res 2002 Apr;62(8):2258-60

Kimmel Cancer Institute, Thomas Jefferson University, 233 South 10th Street, Philadelphia, PA 19107, USA.

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April 2002