Publications by authors named "Hans-Ulrich Schildhaus"

100Publications

[In situ hybridization in molecular pathological diagnostics].

Pathologe 2020 Nov;41(6):561-562

Institut für Pathologie, Universitätsklinikum Essen, Hufelandstraße 55, 45147, Essen, Deutschland.

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http://dx.doi.org/10.1007/s00292-020-00846-0DOI Listing
November 2020

Resistance to avapritinib in PDGFRA-driven GIST is caused by secondary mutations in the PDGFRA kinase domain.

Cancer Discov 2020 Sep 24. Epub 2020 Sep 24.

Department of Medical Oncology, Sarcoma Center, West German Cancer Center, University Duisburg-Essen, Medical School, Essen, Germany; DKTK partner site Essen and German Cancer Consortium (DKTK), Heidelberg, Germany.

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http://dx.doi.org/10.1158/2159-8290.CD-20-0487DOI Listing
September 2020

[Fluorescence in situ hybridization for the diagnosis of soft-tissue and bone tumors].

Pathologe 2020 Nov;41(6):589-605

Institut für Pathologie, Universitätsklinikum Essen, Hufelandstraße 55, 45147, Essen, Deutschland.

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http://dx.doi.org/10.1007/s00292-020-00838-0DOI Listing
November 2020

ERK phosphorylation as a marker of RAS activity and its prognostic value in non-small cell lung cancer.

Lung Cancer 2020 Nov 10;149:10-16. Epub 2020 Sep 10.

Department of Medical Oncology, West German Cancer Center, University Hospital Essen, University Duisburg-Essen, Essen, Germany; Division of Thoracic Oncology, West German Cancer Center, Ruhrlandklinik, University Hospital Essen, University Duisburg-Essen, Essen, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.lungcan.2020.09.005DOI Listing
November 2020

Bone metastasis of retinoblastoma five years after primary treatment.

Am J Ophthalmol Case Rep 2020 Sep 17;19:100834. Epub 2020 Jul 17.

Institute of Pathology, University Hospital Essen, University of Duisburg, Essen, Germany.

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http://dx.doi.org/10.1016/j.ajoc.2020.100834DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7374179PMC
September 2020

Multimodality treatment including surgery for primary pulmonary sarcoma: Size does matter.

J Surg Oncol 2020 Sep 14;122(3):506-514. Epub 2020 May 14.

Department of Thoracic Surgery, University of Duisburg-Essen, Ruhrlandklinik, Essen, Germany.

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http://dx.doi.org/10.1002/jso.25979DOI Listing
September 2020

Pleuropulmonary Blastoma Misinterpreted as Spontaneous Pneumothorax in an Infant.

Ann Thorac Surg 2020 07 17;110(1):e79. Epub 2020 Apr 17.

Department of Thoracic Surgery and Thoracic Endoscopy, University Medicine Essen-Ruhrlandklinik, University Duisburg-Essen, Essen, Germany.

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http://dx.doi.org/10.1016/j.athoracsur.2020.03.033DOI Listing
July 2020

Crizotinib in and Deregulated NSCLC-Letter.

Clin Cancer Res 2020 Apr;26(7):1774

Institute of Pathology, West German Cancer Center, University Hospital Essen, University Duisburg-Essen, Essen, Germany.

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http://dx.doi.org/10.1158/1078-0432.CCR-19-3740DOI Listing
April 2020

Treatment response to idelalisib in a patient with immunodeficiency-associated Burkitt lymphoma harboring a PIK3CA H1047R mutation.

Ann Hematol 2020 Mar 20. Epub 2020 Mar 20.

Department of Haematology and Medical Oncology, University Medicine Göttingen, Göttingen, Germany.

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http://dx.doi.org/10.1007/s00277-020-03974-yDOI Listing
March 2020

[Immunohistochemistry-based predictive biomarkers for lung cancer].

Pathologe 2020 Feb;41(1):21-31

Institut für Pathologie, Universitätsklinikum Essen, Hufelandstraße 55, 45157, Essen, Deutschland.

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http://dx.doi.org/10.1007/s00292-020-00750-7DOI Listing
February 2020

Clinical response to crizotinib and emergence of resistance in lung adenocarcinoma harboring a MET c-Cbl binding site mutation.

Lung Cancer 2020 01 26;139:165-168. Epub 2019 Nov 26.

Department of Medical Oncology, West German Cancer Center, University Hospital Essen, University Duisburg-Essen, Germany; Division of Thoracic Oncology, West German Lung Center, Ruhrlandklinik - University Hospital Essen, University Duisburg-Essen, Germany; German Cancer Consortium (DKTK), Partner Site University Hospital Essen, Germany.

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http://dx.doi.org/10.1016/j.lungcan.2019.11.020DOI Listing
January 2020

Automated density-based counting of FISH amplification signals for HER2 status assessment.

Comput Methods Programs Biomed 2019 May 14;173:77-85. Epub 2019 Mar 14.

Fraunhofer MEVIS, Am Fallturm 1, 28359 Bremen, Germany; Jacobs University, Campus Ring 1, 28759 Bremen, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.cmpb.2019.03.006DOI Listing
May 2019

Loss of RNF40 Decreases NF-κB Activity in Colorectal Cancer Cells and Reduces Colitis Burden in Mice.

J Crohns Colitis 2019 Mar;13(3):362-373

Department of General, Visceral and Pediatric Surgery, Göttingen Center for Molecular Biosciences, University Medical Center Göttingen, Göttingen, Germany.

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http://dx.doi.org/10.1093/ecco-jcc/jjy165DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6599279PMC
March 2019

CIC fusion-positive sarcoma of the spermatic cord.

Virchows Arch 2019 Feb 11;474(2):253-257. Epub 2018 Oct 11.

Institute of Pathology, University Medical Center Göttingen, Robert-Koch-Str.40, 37075, Göttingen, Germany.

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http://dx.doi.org/10.1007/s00428-018-2471-5DOI Listing
February 2019

Using RNA-Seq Data for the Detection of a Panel of Clinically Relevant Mutations.

Stud Health Technol Inform 2018 ;253:217-221

Department of Medical Statistics, University Medical Center Göttingen.

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November 2018

Current Standard and Future Perspectives in the Treatment of Gastrointestinal Stromal Tumors.

Digestion 2017 7;95(4):262-268. Epub 2017 Apr 7.

Clinic for Gastroenterology and Gastrointestinal Oncology, University Medicine, Göttingen, Germany.

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http://dx.doi.org/10.1159/000455835DOI Listing
April 2018

Histone deacetylase class-I inhibition promotes epithelial gene expression in pancreatic cancer cells in a BRD4- and MYC-dependent manner.

Nucleic Acids Res 2017 Jun;45(11):6334-6349

Department of General, Visceral and Pediatric Surgery, Göttingen Center for Molecular Biosciences, University Medical Center Göttingen, Justus-von-Liebig-Weg 11, 37077 Göttingen, Germany.

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http://dx.doi.org/10.1093/nar/gkx212DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5499659PMC
June 2017

Partial Response to First-Line Crizotinib in an Elderly Male Patient with ROS1 Translocation-Positive Lung Cancer.

Case Rep Oncol 2016 Jan-Apr;9(1):158-63. Epub 2016 Mar 10.

Lungentumorzentrum Universität Göttingen and Göttingen Comprehensive Cancer Center (G-CCC), University Hospital Göttingen, Göttingen, Germany; Lungentumorzentrum Universität Göttingen and Göttingen Comprehensive Cancer Center (G-CCC), University Hospital Göttingen, Göttingen, Germany.

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http://dx.doi.org/10.1159/000444745DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4821145PMC
April 2016

Fibroblast Growth Factor Receptor 1 and Related Ligands in Small-Cell Lung Cancer.

J Thorac Oncol 2015 Jul;10(7):1083-90

*Department of Pathology, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Tongji University Institute, Shanghai, People's Republic of China; †Division of Medical Oncology, University of Colorado Anschutz Medical Campus, Aurora, Colorado; ‡Department of Oncology and Radiotherapy, Medical University of Gdansk, Gdansk, Poland; §Institute of Pathology, University Hospital Cologne, Medical Centre, Cologne, Germany; ‖Department of Biostatistics and Informatics, University of Colorado Anschutz Medical Campus, Aurora, Colorado; ¶Department of Craniofacial Biology, University of Colorado Anschutz Medical Campus, Aurora, Colorado; and #Department of Oncology, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Tongji University Institute, Shanghai, People's Republic of China.

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http://dx.doi.org/10.1097/JTO.0000000000000562DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4467588PMC
July 2015

Clear cell papillary renal cell carcinoma and renal angiomyoadenomatous tumor: two variants of a morphologic, immunohistochemical, and genetic distinct entity of renal cell carcinoma.

Am J Surg Pathol 2015 Jul;39(7):889-901

*Institute of Surgical Pathology, University Hospital Zurich, Zurich ‡‡Cantonal Hospital Aarau §§Institute of Histological and Cytological Diagnostics, Aarau ¶¶University Institute of Pathology, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland †Institute of Pathology, University Medicine Göttingen (UMG), Göttingen ∥Institute of Pathology, University Hospital Tübingen, Tübingen ¶Institute of Pathology, HELIOS Hospital Berlin-Buch, Berlin #Institute of Pathology Bogenhausen, Städtisches Klinikum München GmbH, Munich **Institute of Pathology, Heinrich Heine University Hospital, Dusseldorf ††Institute of Pathology, RWTH University, Aachen ∥∥Institute of Pathology, HELIOS Hospital Schwerin, Schwerin ***Institute of Pathology, Städtisches Klinikum Karlsruhe gGmbH, Karlsruhe †††Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany ‡Service d'Anatomie et Cytologie Pathologiques 1, Groupe Hospitalier Pitié-Salpêtrière, Paris, France §Department of Medicine, Renal Division, Brigham and Women's Hospital, Boston, MA ##Institute of Pathology, University of Florence, Florence, Italy.

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http://dx.doi.org/10.1097/PAS.0000000000000456DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4465996PMC
July 2015

c-myc copy number gain is a powerful prognosticator of disease outcome in cervical dysplasia.

Oncotarget 2015 Jan;6(2):825-35

Institute of Pathology, Center for Integrated Oncology, University of Bonn, 53127 Bonn, Germany.Institute of Pathology, Center for Integrated Oncology, University of Cologne, 50937 Cologne, Germany.Institute of Pathology, University of Göttingen, 37075 Göttingen, Germany.

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http://www.oncotarget.com/fulltext/2706
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4359258PMC
http://dx.doi.org/10.18632/oncotarget.2706DOI Listing
January 2015

MET amplification status in therapy-naïve adeno- and squamous cell carcinomas of the lung.

Clin Cancer Res 2015 Feb 9;21(4):907-15. Epub 2014 Dec 9.

Institute of Pathology, University Hospital Cologne, Cologne, Germany. Center for Integrated Oncology, University Hospital Cologne, Cologne, Germany. Targos Molecular Pathology, Kassel, Germany.

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http://dx.doi.org/10.1158/1078-0432.CCR-14-0450DOI Listing
February 2015

Multicenter immunohistochemical ALK-testing of non-small-cell lung cancer shows high concordance after harmonization of techniques and interpretation criteria.

J Thorac Oncol 2014 Nov;9(11):1685-92

*Institute of Pathology, Charité BERLIN, Berlin, Germany; †Institute of Pathology, University of Heidelberg, Heidelberg, Germany; ‡Department of Pathology, Aberdeen University Medical School, Aberdeen, United Kingdom; §Department of Pathology and Cytology, Karolinska University Hospital, Solna, Stockholm, Sweden; ‖Department of Pathology, University Hospital Cologne, Cologne, Germany; ¶Laboratorio de Dianas Terapeuticas, Hospital Universitario Sanchinarro, Madrid, Spain; #Institute of Pathology, Klinikum Großhadern Ludwig-Maximilians-Universität, Munich, Germany; **Institute of Pathology, UZ ANTWERPEN, Edegem, Belgium; ††Institute of Pathology, Klinikum rechts der Isar, TU, Munich, Germany; ‡‡Institute of Pathology, University Hospital Carl Gustav Carus, Dresden, Germany; §§Institute of Pathology, Universitätsspital Basel, Basel, Germany; ‖‖Institute of Pathology, HSK Dr.-Horst-Schmidt-Kliniken GmbH, Wiesbaden, Germany; ¶¶Institute of Pathology, Universitäts Spital Zürich, Zurich, Switzerland; ##Institute of Pathology, Centre Jean Perrin, Clermont-Ferrand, France; ***Patologisk Institut, Århus Universitetshospital, Århus, Denmark; †††Pathology-Berlin, Bioptisches Institut Gemeinschaftspraxis für Pathologie, Berlin, Germany.

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http://dx.doi.org/10.1097/JTO.0000000000000332DOI Listing
November 2014

Challenging dedifferentiated liposarcoma identified by MDM2-amplification, a report of two cases.

BMC Clin Pathol 2014 28;14:36. Epub 2014 Jul 28.

Department of Pathology, University Medical Centre Göttingen, Robert-Koch-Str. 38, 37077 Göttingen, Germany.

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http://dx.doi.org/10.1186/1472-6890-14-36DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4132276PMC
August 2014

Squamous Cell Carcinoma of the Pancreas in a Patient with Germline BRCA2 Mutation-Response to Neoadjuvant Radiochemotherapy.

Case Rep Oncol Med 2014 19;2014:860532. Epub 2014 May 19.

Institute of Pathology, University Hospital Cologne, Kerpener Straße 62, 50924 Cologne, Germany.

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http://dx.doi.org/10.1155/2014/860532DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4052146PMC
June 2014

High-resolution melting analysis is a sensitive diagnostic tool to detect imatinib-resistant and imatinib-sensitive PDGFRA exon 18 mutations in gastrointestinal stromal tumors.

Hum Pathol 2014 Mar 4;45(3):573-82. Epub 2013 Nov 4.

Institute of Pathology, University Hospital Cologne, D-50942 Cologne, Germany; Institute of Pathology, University Hospital Göttingen, D-37075 Göttingen, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.humpath.2013.10.025DOI Listing
March 2014

Rhabdoid morphology in gastrointestinal stromal tumours (GISTs) is associated with PDGFRA mutations but does not imply aggressive behaviour.

Histopathology 2014 Feb 22;64(3):421-30. Epub 2013 Nov 22.

Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Institute of Pathology, University Medical Centre Göttingen, Göttingen, Germany.

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http://doi.wiley.com/10.1111/his.12265
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http://dx.doi.org/10.1111/his.12265DOI Listing
February 2014

Gastrointestinal stromal tumors with KIT exon 9 mutations: Update on genotype-phenotype correlation and validation of a high-resolution melting assay for mutational testing.

Am J Surg Pathol 2013 Nov;37(11):1648-59

*Institute of Pathology, University of Cologne Medical Center, Cologne †Gerhard-Domagk-Institute of Pathology, University of Münster Medical Center, Münster ‡Department of General and Abdominal Surgery, University of Mainz Medical Center, Mainz §Division of Surgical Oncology and Thoracic Surgery, University of Mannheim Medical Center, Mannheim ∥Department of Hematology, Oncology and Palliative Care, Sarcoma Center Berlin-Brandenburg, HELIOS Klinikum Bad Saarow, Bad Saarow, Germany.

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http://dx.doi.org/10.1097/PAS.0b013e3182986b88DOI Listing
November 2013

Fibroblast growth factor receptor 1 (FGFR1) amplification is a potential therapeutic target in small-cell lung cancer.

Mod Pathol 2014 Feb 26;27(2):214-21. Epub 2013 Jul 26.

1] Institute of Pathology, University Hospital Cologne, Cologne, Germany [2] Center for Integrated Oncology Cologne/Bonn, Cologne, Germany [3] Institute of Pathology, University Hospital Göttingen, Göttingen, Germany.

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http://jco.ascopubs.org/content/31/6/731.full.pdf
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http://www.nature.com/doifinder/10.1038/modpathol.2013.141
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http://dx.doi.org/10.1038/modpathol.2013.141DOI Listing
February 2014

Chromogenic in situ hybridization is a reliable assay for detection of ALK rearrangements in adenocarcinomas of the lung.

Mod Pathol 2013 Nov 7;26(11):1468-77. Epub 2013 Jun 7.

Institute of Pathology, University Hospital Cologne (as part of the Lung Cancer Group Cologne (LCGC)), Cologne, Germany.

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http://www.nature.com/articles/modpathol201395
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http://dx.doi.org/10.1038/modpathol.2013.95DOI Listing
November 2013

Evaluation of E-cadherin, Ki-67 and lymphatic vessel invasion in abdominal metastases of human breast cancer.

Anticancer Res 2013 May;33(5):1971-5

Department of Obstetrics and Gynecology, University of Bonn, Sigmund-Freud-Str. 25, 53105 Bonn, Germany.

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http://ar.iiarjournals.org/content/33/5/1971.full.pdf
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May 2013

Activated RET and ROS: two new driver mutations in lung adenocarcinoma.

Transl Lung Cancer Res 2013 Apr;2(2):112-21

Department I of Internal Medicine, University Hospital Cologne, Cologne, Germany ; ; Center for Integrated Oncology Cologne/Bonn, Germany ;

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http://dx.doi.org/10.3978/j.issn.2218-6751.2013.03.08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4369857PMC
April 2013

FGFR1 amplifications in squamous cell carcinomas of the lung: diagnostic and therapeutic implications.

Transl Lung Cancer Res 2013 Apr;2(2):92-100

Institute of Pathology, University Hospital Cologne, Cologne, Germany ; ; Center for Integrated Oncology Cologne/Bonn, Germany ;

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http://dx.doi.org/10.3978/j.issn.2218-6751.2013.03.03DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4369858PMC
April 2013

Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer.

Nat Genet 2012 Oct 2;44(10):1104-10. Epub 2012 Sep 2.

Department of Translational Genomics, University of Cologne, Cologne, Germany.

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http://dx.doi.org/10.1038/ng.2396DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4915822PMC
October 2012

Activating PDGFRA mutations in inflammatory fibroid polyps occur in exons 12, 14 and 18 and are associated with tumour localization.

Histopathology 2012 Jul 6;61(1):59-68. Epub 2012 Mar 6.

Institute of Pathology, University of Cologne Medical Center, Cologne, Germany Institute of Pathology, University of Bonn Medical Center, Bonn, Germany.

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http://dx.doi.org/10.1111/j.1365-2559.2012.04203.xDOI Listing
July 2012

Histologic diagnoses in persistently swollen cervical lymph nodes.

Head Neck 2012 Mar 5;34(3):371-5. Epub 2011 Apr 5.

Department of Otorhinolaryngology, Head and Neck Surgery, University of Bonn, Sigmund-Freud-Str. 25, D-53105 Bonn, Germany.

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http://dx.doi.org/10.1002/hed.21742DOI Listing
March 2012

KIT codon 558 insertions in gastrointestinal stromal tumors. Analysis of 17 rare KIT mutants.

Hum Pathol 2008 Dec 20;39(12):1728-36. Epub 2008 Aug 20.

Department of Soft Tissue Pathology, Armed Forces Institute of Pathology, Washington, DC 20306-6000, USA.

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http://dx.doi.org/10.1016/j.humpath.2008.05.011DOI Listing
December 2008

EGFR and erbB2 in malignant peripheral nerve sheath tumors and implications for targeted therapy.

Neuro Oncol 2008 Dec 23;10(6):946-57. Epub 2008 Jul 23.

Institute of Neuropathology, Charité-Universitätsmedizin Berlin, CVK, Augustenburger Platz 1, D-13353 Berlin, Germany.

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http://dx.doi.org/10.1215/15228517-2008-053DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2719009PMC
December 2008

Mutation analysis of gastrointestinal stromal tumors: increasing significance for risk assessment and effective targeted therapy.

Virchows Arch 2007 Oct 14;451(4):743-9. Epub 2007 Aug 14.

Department of Pathology, University of Bonn Medical School, Sigmund-Freud-Strasse 25, 53127 Bonn, Germany.

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http://dx.doi.org/10.1007/s00428-007-0473-9DOI Listing
October 2007

Cystic cholangiomas after transplantation of pancreatic islets into the livers of diabetic rats.

Virchows Arch 2006 Jun 7;448(6):776-87. Epub 2006 Apr 7.

Institute for Pathology, Otto-von-Guericke-University Magdeburg, Leipziger Strasse 44, 39120 Magdeburg, Germany.

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http://dx.doi.org/10.1007/s00428-006-0196-3DOI Listing
June 2006