Publications by authors named "Hans-Peter Kiem"

100Publications

Purification of Human CD34CD90 HSCs Reduces Target Cell Population and Improves Lentiviral Transduction for Gene Therapy.

Mol Ther Methods Clin Dev 2020 Sep 15;18:679-691. Epub 2020 Jul 15.

Stem Cell and Gene Therapy Program, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.

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http://dx.doi.org/10.1016/j.omtm.2020.07.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7424231PMC
September 2020

CAR T-cell therapy for cancer and HIV through novel approaches to HIV-associated haematological malignancies.

Lancet Haematol 2020 Sep 10;7(9):e690-e696. Epub 2020 Aug 10.

Vaccine and Infectious Diseases Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA; Fred Hutchinson Cancer Research Center, Seattle, WA, USA; Department of Medicine, Division of Medical Oncology, University of Washington, Seattle, WA, USA. Electronic address:

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http://dx.doi.org/10.1016/S2352-3026(20)30142-3DOI Listing
September 2020

Gene Therapy for Canine SCID-X1 Using Cocal-Pseudotyped Lentiviral Vector.

Hum Gene Ther 2020 Sep 23. Epub 2020 Sep 23.

Stem Cell and Gene Therapy Program, Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.

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http://dx.doi.org/10.1089/hum.2020.127DOI Listing
September 2020

Call for Papers: Expanding the Scale and Scope of Therapeutic Gene Editing.

Mol Ther 2020 Aug 16;28(8):1743. Epub 2020 Jul 16.

Department of Pediatrics, Gene and Cell Therapy Program, Herman B. Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN, USA.

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http://dx.doi.org/10.1016/j.ymthe.2020.07.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7403465PMC
August 2020

CRISPR/Cas9 for the treatment of haematological diseases: a journey from bacteria to the bedside.

Br J Haematol 2020 Jun 7. Epub 2020 Jun 7.

Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

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http://dx.doi.org/10.1111/bjh.16807DOI Listing
June 2020

Assessment and streamlined preparation of low-cytotoxicity lentiviral vectors for mobilized human hematopoietic stem cell transduction.

Exp Hematol 2020 Jun 27;86:28-42.e3. Epub 2020 May 27.

Department of Molecular, Cellular and Biomedical Sciences, University of New Hampshire, Durham, NH. Electronic address:

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http://dx.doi.org/10.1016/j.exphem.2020.05.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7372909PMC
June 2020

SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues.

Cell 2020 05 27;181(5):1016-1035.e19. Epub 2020 Apr 27.

Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Program in Immunology, Harvard Medical School, Boston, MA 02115, USA; Division of Gastroenterology, Hepatology, and Nutrition, Boston Children's Hospital, Boston, MA 02115, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2020.04.035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7252096PMC
May 2020

The evolution of viral integration site analysis.

Blood 2020 Apr;135(15):1192-1193

Fred Hutchinson Cancer Research Center.

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http://dx.doi.org/10.1182/blood.2020005115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7146016PMC
April 2020

HLA-Haploidentical Hematopoietic Cell Transplantation for Treatment of Nonmalignant Diseases Using Nonmyeloablative Conditioning and Post-Transplant Cyclophosphamide.

Biol Blood Marrow Transplant 2020 Jul 28;26(7):1332-1341. Epub 2020 Mar 28.

Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington; Department of Pediatrics, University of Washington School of Medicine, Seattle, Washington; Division of Hematology and Oncology, Seattle Children's Hospital, Seattle, Washington. Electronic address:

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http://dx.doi.org/10.1016/j.bbmt.2020.03.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7306430PMC
July 2020

In-Vivo Gene Therapy with Foamy Virus Vectors.

Viruses 2019 11 23;11(12). Epub 2019 Nov 23.

Stem Cell and Gene Therapy Program, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.

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http://dx.doi.org/10.3390/v11121091DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6950547PMC
November 2019

Mouse models in hematopoietic stem cell gene therapy and genome editing.

Biochem Pharmacol 2020 04 6;174:113692. Epub 2019 Nov 6.

Stem Cell and Gene Therapy Program, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA; Department of Medicine, University of Washington School of Medicine, Seattle, WA 98195, USA; Department of Pathology, University of Washington School of Medicine, Seattle, WA 98195, USA.

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http://dx.doi.org/10.1016/j.bcp.2019.113692DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7050335PMC
April 2020

Autologous, Gene-Modified Hematopoietic Stem and Progenitor Cells Repopulate the Central Nervous System with Distinct Clonal Variants.

Stem Cell Reports 2019 07 13;13(1):91-104. Epub 2019 Jun 13.

Division of Clinical Research, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, Mail Stop D1-100, PO Box 19024, Seattle, WA 98109-1024, USA; Department of Medicine, University of Washington, Seattle WA 98195, USA; Department of Pathology, University of Washington, Seattle, WA 98195, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2019.05.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6626873PMC
July 2019

Targeted homology-directed repair in blood stem and progenitor cells with CRISPR nanoformulations.

Nat Mater 2019 10 27;18(10):1124-1132. Epub 2019 May 27.

Cell and Gene Therapy Program, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

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http://dx.doi.org/10.1038/s41563-019-0385-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6754292PMC
October 2019

Lessons from London and Berlin: Designing A Scalable Gene Therapy Approach for HIV Cure.

Cell Stem Cell 2019 05;24(5):685-687

Stem Cell and Gene Therapy Program, Fred Hutchinson Cancer Research Center, Seattle, WA 98109-1024, USA; Department of Medicine, University of Washington, Seattle, WA 98195, USA; Department of Pathology, University of Washington, Seattle, WA 98195, USA; Washington National Primate Research Center, Seattle, WA 98195, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S19345909193015
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http://dx.doi.org/10.1016/j.stem.2019.04.010DOI Listing
May 2019

Preparation and Gene Modification of Nonhuman Primate Hematopoietic Stem and Progenitor Cells.

J Vis Exp 2019 02 15(144). Epub 2019 Feb 15.

Stem Cell and Gene Therapy Program, Fred Hutchinson Cancer Research Center; Department of Medicine, University of Washington;

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http://dx.doi.org/10.3791/58933DOI Listing
February 2019

TALEN-Mediated Gene Editing of in Human Hematopoietic Stem Cells Leads to Therapeutic Fetal Hemoglobin Induction.

Mol Ther Methods Clin Dev 2019 Mar 31;12:175-183. Epub 2018 Dec 31.

Center for Immunity and Immunotherapies and the Program for Cell and Gene Therapy, Seattle Children's Research Institute, Seattle, WA 98101, USA.

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http://dx.doi.org/10.1016/j.omtm.2018.12.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348980PMC
March 2019

MISTRG mice support engraftment and assessment of nonhuman primate hematopoietic stem and progenitor cells.

Exp Hematol 2019 02 25;70:31-41.e1. Epub 2018 Dec 25.

Program in Immunology, Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA; Department of Immunology, University of Washington School of Medicine, Seattle, WA. Electronic address:

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http://dx.doi.org/10.1016/j.exphem.2018.12.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6719784PMC
February 2019

Long-Term Persistence of Anti-HIV Broadly Neutralizing Antibody-Secreting Hematopoietic Cells in Humanized Mice.

Mol Ther 2019 01 27;27(1):164-177. Epub 2018 Sep 27.

Stem Cell and Gene Therapy Program, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109-1024, USA; Department of Medicine, University of Washington, Seattle, WA, 98195, USA; Department of Pathology, University of Washington, Seattle, WA, 98195, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15250016183045
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http://dx.doi.org/10.1016/j.ymthe.2018.09.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318702PMC
January 2019

Sorting Out the Best: Enriching Hematopoietic Stem Cells for Gene Therapy and Editing.

Mol Ther 2018 10 13;26(10):2328-2329. Epub 2018 Sep 13.

Stem Cell and Gene Therapy Program, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA; Department of Medicine, University of Washington School of Medicine, Seattle, WA 98195, USA; Department of Pathology, University of Washington School of Medicine, Seattle, WA 98195, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ymthe.2018.08.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6171164PMC
October 2018

Minimal conditioning in Fanconi anemia promotes multi-lineage marrow engraftment at 10-fold lower cell doses.

J Gene Med 2018 10 1;20(10-11):e3050. Epub 2018 Oct 1.

Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

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http://doi.wiley.com/10.1002/jgm.3050
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http://dx.doi.org/10.1002/jgm.3050DOI Listing
October 2018

Chimeric antigen receptor T-cell approaches to HIV cure.

Curr Opin HIV AIDS 2018 09;13(5):446-453

Stem Cell and Gene Therapy Program, Fred Hutchinson Cancer Research Center.

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http://dx.doi.org/10.1097/COH.0000000000000485DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6993924PMC
September 2018

Next-Generation Conditioning for Bone Marrow Transplantation: Paving the Way for CAR-T Cell-Based Conditioning.

Mol Ther 2018 05;26(5):1167-1168

Stem Cell and Gene Therapy Program, Fred Hutchinson Cancer Research Center, Seattle, WA, USA; Department of Medicine, University of Washington, Seattle, WA, USA; Department of Pathology, University of Washington, Seattle, WA, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15250016183016
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http://dx.doi.org/10.1016/j.ymthe.2018.04.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5993962PMC
May 2018

A Nonhuman Primate Transplantation Model to Evaluate Hematopoietic Stem Cell Gene Editing Strategies for β-Hemoglobinopathies.

Mol Ther Methods Clin Dev 2018 Mar 21;8:75-86. Epub 2017 Nov 21.

Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

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http://dx.doi.org/10.1016/j.omtm.2017.11.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5738324PMC
March 2018

Cell and Gene Therapy for HIV Cure.

Curr Top Microbiol Immunol 2018;417:211-248

Fred Hutchinson Cancer Research Center, University of Washington School of Medicine, Seattle, WA, 98109-1024, USA.

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http://dx.doi.org/10.1007/82_2017_71DOI Listing
June 2019

Hematopoietic Stem Cell Approaches to Cancer.

Hematol Oncol Clin North Am 2017 10;31(5):897-912

Stem Cell and Gene Therapy Program, Fred Hutchison Cancer Research Center, 1100 Fairview Avenue N. D1-100 Seattle, WA 98109-1024, USA. Electronic address:

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http://dx.doi.org/10.1016/j.hoc.2017.06.012DOI Listing
October 2017

In Vivo Hematopoietic Stem Cell Transduction.

Hematol Oncol Clin North Am 2017 10;31(5):771-785

Division of Medical Genetics, University of Washington, 1705 NE Pacific Street, Seattle, WA 98195, USA; Department of Pathology, University of Washington, 1705 NE Pacific Street, Seattle, WA 98195, USA. Electronic address:

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http://dx.doi.org/10.1016/j.hoc.2017.06.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5659626PMC
October 2017

Nanoparticle Biokinetics in Mice and Nonhuman Primates.

ACS Nano 2017 09 18;11(9):9514-9524. Epub 2017 Sep 18.

Clinical Research Division, Fred Hutchinson Cancer Research Center , Seattle, Washington 98109, United States.

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http://dx.doi.org/10.1021/acsnano.7b05377DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6002853PMC
September 2017

CCR5-edited gene therapies for HIV cure: Closing the door to viral entry.

Cytotherapy 2017 11 24;19(11):1325-1338. Epub 2017 Jul 24.

Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA; Department of Medicine, University of Washington, Seattle, Washington, USA; Department of Pathology, University of Washington, Seattle, Washington, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jcyt.2017.05.013DOI Listing
November 2017

In Vivo Murine-Matured Human CD3 Cells as a Preclinical Model for T Cell-Based Immunotherapies.

Mol Ther Methods Clin Dev 2017 Sep 17;6:17-30. Epub 2017 May 17.

Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109-1024, USA.

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http://dx.doi.org/10.1016/j.omtm.2017.05.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5470556PMC
September 2017

Autologous Stem Cell Transplantation Disrupts Adaptive Immune Responses during Rebound Simian/Human Immunodeficiency Virus Viremia.

J Virol 2017 07 9;91(13). Epub 2017 Jun 9.

Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA

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http://dx.doi.org/10.1128/JVI.00095-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5469274PMC
July 2017

Safe and Effective Gene Therapy for Murine Wiskott-Aldrich Syndrome Using an Insulated Lentiviral Vector.

Mol Ther Methods Clin Dev 2017 Mar 18;4:1-16. Epub 2016 Dec 18.

Center for Immunity and Immunotherapies and Program for Cell and Gene Therapy, Seattle Children's Research Institute, Seattle, WA 98101, USA; Department of Pediatrics, University of Washington, Seattle, WA 98105, USA; Department of Immunology, University of Washington, Seattle, WA 98105, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S23290501163012
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http://dx.doi.org/10.1016/j.omtm.2016.11.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5363182PMC
March 2017

Lessons Learned from Two Decades of Clinical Trial Experience in Gene Therapy for Fanconi Anemia.

Curr Gene Ther 2017 ;16(5):338-348

Centro de Investigaciones Energeticas, Medioambientales y Tecnologicas (CIEMAT) Madrid, Spain.

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http://dx.doi.org/10.2174/1566523217666170119113029DOI Listing
July 2018

Devouring the Hematopoietic Stem Cell: Setting the Table for Marrow Cell Transplantation.

Mol Ther 2016 11;24(11):1892-1894

Fred Hutchinson Cancer Research Center and University of Washington School of Medicine, Seattle, Washington, USA.

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http://dx.doi.org/10.1038/mt.2016.193DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5154489PMC
November 2016

Semi-automated closed system manufacturing of lentivirus gene-modified haematopoietic stem cells for gene therapy.

Nat Commun 2016 10 20;7:13173. Epub 2016 Oct 20.

Clinical Research Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, Washington 98109, USA.

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http://dx.doi.org/10.1038/ncomms13173DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5080442PMC
October 2016

Efficient Modification of the CCR5 Locus in Primary Human T Cells With megaTAL Nuclease Establishes HIV-1 Resistance.

Mol Ther Nucleic Acids 2016 Aug 23;5(8):e352. Epub 2016 Aug 23.

Center for Immunity and Immunotherapies and Program for Cell and Gene Therapy, Seattle Children's Research Institute, Seattle, Washington, USA.

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http://dx.doi.org/10.1038/mtna.2016.56DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5023401PMC
August 2016

The frequency of multipotent CD133(+)CD45RA(-)CD34(+) hematopoietic stem cells is not increased in fetal liver compared with adult stem cell sources.

Exp Hematol 2016 06 22;44(6):502-7. Epub 2016 Mar 22.

Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA; Department of Medicine, University of Washington School of Medicine, Seattle, WA; Department of Pathology, University of Washington School of Medicine, Seattle, WA. Electronic address:

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http://dx.doi.org/10.1016/j.exphem.2016.02.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5565165PMC
June 2016

Multilineage polyclonal engraftment of Cal-1 gene-modified cells and in vivo selection after SHIV infection in a nonhuman primate model of AIDS.

Mol Ther Methods Clin Dev 2016 24;3:16007. Epub 2016 Feb 24.

Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA; Department of Medicine, University of Washington, Seattle, Washington, USA.

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http://dx.doi.org/10.1038/mtm.2016.7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4765711PMC
March 2016

A curative regimen would decrease HIV prevalence but not HIV incidence unless targeted to an ART-naïve population.

Sci Rep 2016 Feb 24;6:22183. Epub 2016 Feb 24.

Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.

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http://dx.doi.org/10.1038/srep22183DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4764923PMC
February 2016

Lack of viral control and development of combination antiretroviral therapy escape mutations in macaques after bone marrow transplantation.

AIDS 2015 Aug;29(13):1597-606

aClinical Research Division, Fred Hutchinson Cancer Research Center bWashington National Primate Research Center, Seattle cVaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington dDivision of Pharmacotherapy and Experimental Therapeutics, University of North Carolina, Chapel Hill, North Carolina eDepartment of Microbiology fDepartment of Pediatrics gDepartment of Laboratory Medicine hDepartment of Medicine iDepartment of Pharmaceutics jDepartment of Pathology, University of Washington, Seattle, Washington, USA. *Christopher W. Peterson and Kevin G. Haworth contributed equally to the writing of this article.

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http://pdfs.journals.lww.com/aidsonline/2015/08240/Lack_of_v
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http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
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http://dx.doi.org/10.1097/QAD.0000000000000702DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4572605PMC
August 2015

Safety and Efficacy of Combination Antiretroviral Therapy in Human Immunodeficiency Virus-Infected Adults Undergoing Autologous or Allogeneic Hematopoietic Cell Transplantation for Hematologic Malignancies.

Biol Blood Marrow Transplant 2016 Jan 8;22(1):149-56. Epub 2015 Aug 8.

Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington; Department of Pediatrics, University of Washington, Seattle, Washington. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10838791150053
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http://dx.doi.org/10.1016/j.bbmt.2015.08.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4731235PMC
January 2016

C peptides as entry inhibitors for gene therapy.

Adv Exp Med Biol 2015 ;848:191-209

Division of Virology, Department of Hygiene, Microbiology and Social Medicine, Medical University of Innsbruck, Peter Mayr-Str. 4b, Innsbruck, 6020, Austria,

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http://dx.doi.org/10.1007/978-1-4939-2432-5_10DOI Listing
July 2015

Lentivirus-mediated Gene Transfer in Hematopoietic Stem Cells Is Impaired in SHIV-infected, ART-treated Nonhuman Primates.

Mol Ther 2015 May 4;23(5):943-951. Epub 2015 Feb 4.

Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA; Department of Medicine, University of Washington, Seattle, Washington, USA. Electronic address:

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http://dx.doi.org/10.1038/mt.2015.19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4427875PMC
May 2015

Gene therapy studies in a canine model of X-linked severe combined immunodeficiency.

Hum Gene Ther Clin Dev 2015 Mar 24;26(1):50-6. Epub 2015 Feb 24.

1 Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania , Philadelphia, PA 19104.

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http://dx.doi.org/10.1089/humc.2015.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4442583PMC
March 2015

Cord blood expansion. Pyrimidoindole derivatives are agonists of human hematopoietic stem cell self-renewal.

Science 2014 Sep;345(6203):1509-12

Molecular Genetics of Stem Cells Laboratory, Institute of Research in Immunology and Cancer (IRIC), University of Montreal, Montreal, QC, Canada. Division of Hematology, Maisonneuve-Rosemont Hospital, Montreal, QC, Canada. Department of Medicine, Faculty of Medicine, Université de Montreal, Montreal, QC, Canada.

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http://dx.doi.org/10.1126/science.1256337DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4372335PMC
September 2014

High-throughput genomic mapping of vector integration sites in gene therapy studies.

Methods Mol Biol 2014 ;1185:321-44

Fred Hutchinson Cancer Research Center, University of Washington School of Medicine, Seattle, WA, USA.

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http://dx.doi.org/10.1007/978-1-4939-1133-2_22DOI Listing
March 2015

Modeling promising nonmyeloablative conditioning regimens in nonhuman primates.

Hum Gene Ther 2014 Dec;25(12):1013-22

1 Clinical Research Division, Fred Hutchinson Cancer Research Center , Seattle, WA 98109.

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http://dx.doi.org/10.1089/hum.2014.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4270134PMC
December 2014

Human embryonic-stem-cell-derived cardiomyocytes regenerate non-human primate hearts.

Nature 2014 Jun 30;510(7504):273-7. Epub 2014 Apr 30.

1] Center for Cardiovascular Biology, University of Washington, Seattle, Washington 98109, USA [2] Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, Washington 98109, USA [3] Department of Pathology, University of Washington, Seattle, Washington 98195, USA [4] Department of Medicine/Cardiology, University of Washington, Seattle, Washington 98195, USA [5] Department of Bioengineering, University of Washington, Seattle, Washington 98195, USA.

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http://dx.doi.org/10.1038/nature13233DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4154594PMC
June 2014

HIV eradication--from Berlin to Boston.

Nat Biotechnol 2014 Apr;32(4):315-6

Fred Hutchinson Cancer Research Center and University of Washington, Seattle, Washington, USA.

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http://dx.doi.org/10.1038/nbt.2868DOI Listing
April 2014

No evidence of clonal dominance after transplant of HOXB4-expanded cord blood cells in a nonhuman primate model.

Exp Hematol 2014 Jul 2;42(7):497-504. Epub 2014 Apr 2.

Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA; Department of Medicine, University of Washington, Seattle, WA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.exphem.2014.03.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4287401PMC
July 2014

Intravenous injection of a foamy virus vector to correct canine SCID-X1.

Blood 2014 Jun 18;123(23):3578-84. Epub 2014 Mar 18.

Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA; Department of Medicine, University of Washington, Seattle, WA;

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http://dx.doi.org/10.1182/blood-2013-11-538926DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4047497PMC
June 2014

Ectopic expression of HOXC6 blocks myeloid differentiation and predisposes to malignant transformation.

Exp Hematol 2014 Feb 26;42(2):114-25.e4. Epub 2013 Oct 26.

Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, 98109, USA.

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http://dx.doi.org/10.1016/j.exphem.2013.10.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4062101PMC
February 2014

Pigtailed macaques as a model to study long-term safety of lentivirus vector-mediated gene therapy for hemoglobinopathies.

Mol Ther Methods Clin Dev 2014 17;1:14055. Epub 2014 Dec 17.

Division of Experimental Hematology and Cancer Biology, Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center , Cincinnati, Ohio, USA.

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http://dx.doi.org/10.1038/mtm.2014.55DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4448740PMC
June 2015

Genetic modification of hematopoietic stem cells as a therapy for HIV/AIDS.

Viruses 2013 Nov 28;5(12):2946-62. Epub 2013 Nov 28.

Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.

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http://dx.doi.org/10.3390/v5122946DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3967155PMC
November 2013

Genetically modified hematopoietic stem cell transplantation for HIV-1-infected patients: can we achieve a cure?

Mol Ther 2014 Feb 13;22(2):257-264. Epub 2013 Nov 13.

Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA; Department of Medicine, University of Washington, Seattle, Washington, USA. Electronic address:

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http://dx.doi.org/10.1038/mt.2013.264DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3916050PMC
February 2014